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URLhttps://www.womenshealthmag.com/health/a19611716/melatonin-side-effects/
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Meta TitleThe Melatonin Side Effects You Should Know About
Meta DescriptionMelatonin is a popular sleep aid used by more than 1million people in the U.S. But it does some with side effects. Here are the melatonin side effects you should know about.
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If you’re like the 88 percent of women regularly not sleeping through the night (according to a recent Women's Health survey), you’ve probably found yourself looking for alternatives to counting sheep. Last year, the National Institutes of Health reported that 3.1 million Americans used melatonin supplements to fall asleep. “Melatonin is a natural hormone secreted by your brain that helps regulate your circadian rhythm, or when your body wants to wake up and go to sleep,” says Jocelyn Cheng , M.D., a neurologist at NYU Langone Health. Studies have actually shown that melatonin can help people with sleep disorders fall asleep anywhere between 27 and 50 minutes faster. But before you go buy out your local vitamin shop's stock, remember: “A supplement is not a regulated drug, so there’s always a question as to whether you’re getting what it claims to be,” warns Rachel Salas , M.D., a neurologist with a focus on sleep disorders and sleep medicine at Johns Hopkins Medicine. One study actually found that 71 percent of melatonin supplements did not meet the claims on the label, with some listing up to five times the amount of the hormone than it actually contained. Look for supplements displaying seals from the United States Pharmacopeial Convention or NSF International so you know the manufacturers are legit. Of course, like any drug or supplement, melatonin can come with some side effects. While many of the potential side effects listed on the internet—like short-lasting feelings of depression , dizziness, low blood pressure, or mild irritability or anxiety—are exceedingly rare, doctors say these four melatonin side effects occur with slightly more regularity: Drowsiness The biggest side effect that comes with melatonin is actually grogginess. “It’s like a hangover,” says Salas. That feeling of grogginess or not wanting to to get up is something that’s often associated with sleep aids. “That’s just really the nature of the game of promoting sleepiness,” she says. “In some individuals, the sleep effect can hang around in the body a little bit longer—their body may not process the supplement as quickly, and so they’re still experiencing the effects when they wake up,” says Salas. Insomnia “The most common thing I hear from patients is that melatonin doesn’t work,” says Salas. Patients often expect the drug to work more like a sleeping pill than a sleep aid—and as a result, don't take it properly. Your body naturally produces a surge in melatonin around 7 p.m., says W. Christopher Winter, M.D., president of Charlottesville Neurology and Sleep Medicine and author of The Sleep Solution: Why Your Sleep Is Broken and How to Fix It . “That’s why it’s really meant to be taken at sundown, to help boost your body’s natural production and send your brain the message that bedtime is coming,” he explains. “If not taken properly, it can actually make it harder to sleep.” So if you want until 11 p.m. to take it, it may already be too late for it to do its job. Headache Most medications include headaches as a common side effect. “When people take a new drug or supplement, prescribed or not, their bodies may react differently and headaches are a typical response to that,” says Salas. Not to mention, “melatonin is tied to your circadian rhythm, and anything that relates to the timing of your body can be affected when you take it,” says Winter. Timing matters here because if your body isn’t on the right sleep schedule (i.e. you’re taking the melatonin late and still waking up early), you could end up waking up during deeper REM sleep, which would leave you feeling headachy. Gastrointestinal Issues Nausea, constipation, and an upset stomach are all common reactions to medication, and could come with taking melatonin. “The ingredients in a drug or supplement can change—even what’s holding the tablet or the capsule together—and that could cause irritation in your GI system,” says Salas. She often warns her patients to avoid buying melatonin in bulk until their know how their body is going to react. “You might have GI effects with one brand versus another, so it’s worth waiting to see what happens before committing to a specific supplement.” Ashley Mateo is a writer, editor, and UESCA- and RRCA-certified running coach who has contributed to Runner’s World, Bicycling, Women's Health, Health, Shape, Self, and more. She’ll go anywhere in the world once—even if it’s just for a good story. Also into: good pizza, good beer, and good photos.
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[Health](https://www.womenshealthmag.com/health/) 2. [The Melatonin Side Effects You Should Know About](https://www.womenshealthmag.com/health/a19611716/melatonin-side-effects/) # The Melatonin Side Effects You Should Know About Yes, it could cause insomnia. By [Ashley Mateo](https://www.womenshealthmag.com/author/4834/ashley-mateo/ "Ashley Mateo") Published: Mar 28, 2018 10:43 AM EDT Save Article ![Open share options](https://www.womenshealthmag.com/_assets/design-tokens/fre/static/icons/social/sharing.89c15b8.svg?primary=%2523262626) ![melatonin side effects](https://hips.hearstapps.com/hmg-prod/images/gettyimages-709139587-1522189973.jpg?resize=640:*) Getty Images Women's Health may earn commission from the links on this page, but we only feature products we believe in. [Why Trust Us?](https://www.womenshealthmag.com/about/a24170223/about-womens-health/) If you’re like the 88 percent of women regularly not sleeping through the night (according to a recent *Women's Health* survey), you’ve probably found yourself looking for alternatives to counting sheep. Last year, the [National Institutes of Health](https://nccih.nih.gov/research/statistics/NHIS/2012/natural-products/melatonin) reported that 3.1 million Americans used melatonin supplements to fall asleep. “Melatonin is a natural hormone secreted by your brain that helps regulate your circadian rhythm, or when your body wants to wake up and go to sleep,” says [Jocelyn Cheng](https://nyulangone.org/doctors/1063623759/jocelyn-y-cheng), M.D., a neurologist at NYU Langone Health. [Studies](https://www.ncbi.nlm.nih.gov/books/NBK11941/) have actually shown that melatonin can help people with sleep disorders fall asleep anywhere between 27 and 50 minutes faster. But before you go buy out your local vitamin shop's stock, remember: “A supplement is not a regulated drug, so there’s always a question as to whether you’re getting what it claims to be,” warns [Rachel Salas](https://www.hopkinsmedicine.org/profiles/results/directory/profile/0021181/rachel-salas), M.D., a neurologist with a focus on sleep disorders and sleep medicine at Johns Hopkins Medicine. One [study](http://jcsm.aasm.org/ViewAbstract.aspx?pid=30950&_ga=2.124622858.1836393414.1521479015-619533109.1519571049) actually found that 71 percent of melatonin supplements did not meet the claims on the label, with some listing up to five times the amount of the hormone than it actually contained. Look for supplements displaying seals from the [United States Pharmacopeial Convention](http://www.quality-supplements.org/verified-products) or [NSF International](https://www.nsf.org/services/by-industry/dietary-supplements/) so you know the manufacturers are legit. ## Related Story - [![](data:image/svg+xml;utf8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201024%201024'%3E%3Crect%20width%3D'100%25'%20height%3D'100%25'%20fill%3D'%23f3f3f3'%2F%3E%3Cg%20fill%3D'none'%20stroke%3D'%23545454'%20stroke-linecap%3D'round'%20stroke-width%3D'18'%3E%3Ccircle%20cx%3D'512'%20cy%3D'310'%20r%3D'97'%2F%3E%3Cpath%20d%3D'm444%20245%20132%20133'%2F%3E%3C%2Fg%3E%3Cg%20fill%3D'%23545454'%20font-family%3D'Arial%2CHelvetica%2Csans-serif'%20font-size%3D'98'%20font-weight%3D'600'%20text-anchor%3D'middle'%3E%3Ctext%20x%3D'514'%20y%3D'535'%3EIMAGE%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'643'%3EFAILED%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'747'%3ETO%20LOAD%3C%2Ftext%3E%3C%2Fg%3E%3C%2Fsvg%3E)41 Percent Of Americans Prefer To Sleep Alone](https://www.womenshealthmag.com/relationships/a18734107/partner-sleep-study/) Of course, like any drug or supplement, melatonin can come with some side effects. While many of the potential side effects listed on the internet—like short-lasting feelings of [depression](https://www.womenshealthmag.com/health/a19920419/depression-symptoms-in-women/), dizziness, low blood pressure, or mild irritability or anxiety—are exceedingly rare, doctors say these four melatonin side effects occur with slightly more regularity: ## Drowsiness ![giphy](https://www.womenshealthmag.com/_assets/design-tokens/fre/static/icons/social/giphy.32c59ed.svg?primary=currentColor&id=link-out-embed)[View full post on GIPHY](https://giphy.com/embed/14hveW09nZPsZO) The biggest side effect that comes with melatonin is actually grogginess. “It’s like a hangover,” says Salas. That feeling of grogginess or not wanting to to get up is something that’s often associated with sleep aids. “That’s just really the nature of the game of promoting sleepiness,” she says. “In some individuals, the sleep effect can hang around in the body a little bit longer—their body may not process the supplement as quickly, and so they’re still experiencing the effects when they wake up,” says Salas. ## Insomnia ![giphy](https://www.womenshealthmag.com/_assets/design-tokens/fre/static/icons/social/giphy.32c59ed.svg?primary=currentColor&id=link-out-embed)[View full post on GIPHY](https://giphy.com/embed/3ohjVbAWsK044UTDBC) “The most common thing I hear from patients is that melatonin doesn’t work,” says Salas. Patients often expect the drug to work more like a [sleeping pill](https://www.womenshealthmag.com/health/a19932088/sleeping-pill-dangers/) than a sleep aid—and as a result, don't take it properly. Your body naturally produces a surge in melatonin around 7 p.m., says W. Christopher Winter, M.D., president of [Charlottesville Neurology and Sleep Medicine](http://www.cvilleneuroandsleep.com/) and author of *[The Sleep Solution: Why Your Sleep Is Broken and How to Fix It](https://www.amazon.com/dp/0399583610?tag=womenshealth-auto-20)*. “That’s why it’s really meant to be taken at sundown, to help boost your body’s natural production and send your brain the message that bedtime is coming,” he explains. “If not taken properly, it can actually make it harder to sleep.” So if you want until 11 p.m. to take it, it may already be too late for it to do its job. ## Headache ![giphy](https://www.womenshealthmag.com/_assets/design-tokens/fre/static/icons/social/giphy.32c59ed.svg?primary=currentColor&id=link-out-embed)[View full post on GIPHY](https://giphy.com/embed/y9v6gGKHjBX7W) Most medications include [headaches](https://www.womenshealthmag.com/health/a19919224/headaches/) as a common side effect. “When people take a new drug or supplement, prescribed or not, their bodies may react differently and headaches are a typical response to that,” says Salas. ## Related Story - [![](data:image/svg+xml;utf8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201024%201024'%3E%3Crect%20width%3D'100%25'%20height%3D'100%25'%20fill%3D'%23f3f3f3'%2F%3E%3Cg%20fill%3D'none'%20stroke%3D'%23545454'%20stroke-linecap%3D'round'%20stroke-width%3D'18'%3E%3Ccircle%20cx%3D'512'%20cy%3D'310'%20r%3D'97'%2F%3E%3Cpath%20d%3D'm444%20245%20132%20133'%2F%3E%3C%2Fg%3E%3Cg%20fill%3D'%23545454'%20font-family%3D'Arial%2CHelvetica%2Csans-serif'%20font-size%3D'98'%20font-weight%3D'600'%20text-anchor%3D'middle'%3E%3Ctext%20x%3D'514'%20y%3D'535'%3EIMAGE%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'643'%3EFAILED%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'747'%3ETO%20LOAD%3C%2Ftext%3E%3C%2Fg%3E%3C%2Fsvg%3E)The Best White Noise Machine. Period.](https://www.womenshealthmag.com/health/a16761502/marpac-dohm-white-noise-machine-review/) Not to mention, “melatonin is tied to your circadian rhythm, and anything that relates to the timing of your body can be affected when you take it,” says Winter. Timing matters here because if your body isn’t on the right sleep schedule (i.e. you’re taking the melatonin late and still waking up early), you could end up waking up during deeper REM sleep, which would leave you feeling headachy. ## Gastrointestinal Issues ![giphy](https://www.womenshealthmag.com/_assets/design-tokens/fre/static/icons/social/giphy.32c59ed.svg?primary=currentColor&id=link-out-embed)[View full post on GIPHY](https://giphy.com/embed/ArdcEgTjLfxDO) Nausea, constipation, and an upset stomach are all common reactions to medication, and could come with taking melatonin. “The ingredients in a drug or supplement can change—even what’s holding the tablet or the capsule together—and that could cause irritation in your GI system,” says Salas. She often warns her patients to avoid buying melatonin in bulk until their know how their body is going to react. “You might have GI effects with one brand versus another, so it’s worth waiting to see what happens before committing to a specific supplement.” ![Headshot of Ashley Mateo](data:image/svg+xml;utf8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201024%201024'%3E%3Crect%20width%3D'100%25'%20height%3D'100%25'%20fill%3D'%23f3f3f3'%2F%3E%3Cg%20fill%3D'none'%20stroke%3D'%23545454'%20stroke-linecap%3D'round'%20stroke-width%3D'18'%3E%3Ccircle%20cx%3D'512'%20cy%3D'310'%20r%3D'97'%2F%3E%3Cpath%20d%3D'm444%20245%20132%20133'%2F%3E%3C%2Fg%3E%3Cg%20fill%3D'%23545454'%20font-family%3D'Arial%2CHelvetica%2Csans-serif'%20font-size%3D'98'%20font-weight%3D'600'%20text-anchor%3D'middle'%3E%3Ctext%20x%3D'514'%20y%3D'535'%3EIMAGE%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'643'%3EFAILED%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'747'%3ETO%20LOAD%3C%2Ftext%3E%3C%2Fg%3E%3C%2Fsvg%3E) [Ashley Mateo](https://www.womenshealthmag.com/author/4834/ashley-mateo/) Ashley Mateo is a writer, editor, and UESCA- and RRCA-certified running coach who has contributed to Runner’s World, Bicycling, Women's Health, Health, Shape, Self, and more. She’ll go anywhere in the world once—even if it’s just for a good story. Also into: good pizza, good beer, and good photos. Watch NextUltimate Pull-Up Plan Trailer \| Women's Health ![Play video](<data:image/svg+xml,\<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="%23ffffff" viewBox="0 0 256 256"\>%0A%09\<path d="M240,128a15.74,15.74,0,0,1-7.6,13.51L88.32,229.65a16,16,0,0,1-16.2.3A15.86,15.86,0,0,1,64,216.13V39.87a15.86,15.86,0,0,1,8.12-13.82,16,16,0,0,1,16.2.3L232.4,114.49A15.74,15.74,0,0,1,240,128Z"\>%0A\</path\>\</svg\>>) ![Video poster](https://hips.hearstapps.com/vidthumb/737c5491-f170-4203-9369-afa89e08b644/thumb_1920x1080.0000001.jpg?crop=1xw:1xh;center,top) Ultimate Pull-Up Plan Trailer \| Women's Health Women's Health US ![Playlist Back](<data:image/svg+xml,\<svg xmlns="http://www.w3.org/2000/svg" width="24" height="24" fill="%23ffffff" viewBox="0 0 256 256"\>%0A%09\<path d="M208,47.88V208.12a16,16,0,0,1-24.43,13.43L64,146.77V216a8,8,0,0,1-16,0V40a8,8,0,0,1,16,0v69.23L183.57,34.45A15.95,15.95,0,0,1,208,47.88Z"\>\</path\>%0A\</svg\>>) ![Play](<data:image/svg+xml,\<svg 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Readable Markdown
If you’re like the 88 percent of women regularly not sleeping through the night (according to a recent *Women's Health* survey), you’ve probably found yourself looking for alternatives to counting sheep. Last year, the [National Institutes of Health](https://nccih.nih.gov/research/statistics/NHIS/2012/natural-products/melatonin) reported that 3.1 million Americans used melatonin supplements to fall asleep. “Melatonin is a natural hormone secreted by your brain that helps regulate your circadian rhythm, or when your body wants to wake up and go to sleep,” says [Jocelyn Cheng](https://nyulangone.org/doctors/1063623759/jocelyn-y-cheng), M.D., a neurologist at NYU Langone Health. [Studies](https://www.ncbi.nlm.nih.gov/books/NBK11941/) have actually shown that melatonin can help people with sleep disorders fall asleep anywhere between 27 and 50 minutes faster. But before you go buy out your local vitamin shop's stock, remember: “A supplement is not a regulated drug, so there’s always a question as to whether you’re getting what it claims to be,” warns [Rachel Salas](https://www.hopkinsmedicine.org/profiles/results/directory/profile/0021181/rachel-salas), M.D., a neurologist with a focus on sleep disorders and sleep medicine at Johns Hopkins Medicine. One [study](http://jcsm.aasm.org/ViewAbstract.aspx?pid=30950&_ga=2.124622858.1836393414.1521479015-619533109.1519571049) actually found that 71 percent of melatonin supplements did not meet the claims on the label, with some listing up to five times the amount of the hormone than it actually contained. Look for supplements displaying seals from the [United States Pharmacopeial Convention](http://www.quality-supplements.org/verified-products) or [NSF International](https://www.nsf.org/services/by-industry/dietary-supplements/) so you know the manufacturers are legit. Of course, like any drug or supplement, melatonin can come with some side effects. While many of the potential side effects listed on the internet—like short-lasting feelings of [depression](https://www.womenshealthmag.com/health/a19920419/depression-symptoms-in-women/), dizziness, low blood pressure, or mild irritability or anxiety—are exceedingly rare, doctors say these four melatonin side effects occur with slightly more regularity: ## Drowsiness The biggest side effect that comes with melatonin is actually grogginess. “It’s like a hangover,” says Salas. That feeling of grogginess or not wanting to to get up is something that’s often associated with sleep aids. “That’s just really the nature of the game of promoting sleepiness,” she says. “In some individuals, the sleep effect can hang around in the body a little bit longer—their body may not process the supplement as quickly, and so they’re still experiencing the effects when they wake up,” says Salas. ## Insomnia “The most common thing I hear from patients is that melatonin doesn’t work,” says Salas. Patients often expect the drug to work more like a [sleeping pill](https://www.womenshealthmag.com/health/a19932088/sleeping-pill-dangers/) than a sleep aid—and as a result, don't take it properly. Your body naturally produces a surge in melatonin around 7 p.m., says W. Christopher Winter, M.D., president of [Charlottesville Neurology and Sleep Medicine](http://www.cvilleneuroandsleep.com/) and author of *[The Sleep Solution: Why Your Sleep Is Broken and How to Fix It](https://www.amazon.com/dp/0399583610?tag=womenshealth-auto-20)*. “That’s why it’s really meant to be taken at sundown, to help boost your body’s natural production and send your brain the message that bedtime is coming,” he explains. “If not taken properly, it can actually make it harder to sleep.” So if you want until 11 p.m. to take it, it may already be too late for it to do its job. ## Headache Most medications include [headaches](https://www.womenshealthmag.com/health/a19919224/headaches/) as a common side effect. “When people take a new drug or supplement, prescribed or not, their bodies may react differently and headaches are a typical response to that,” says Salas. Not to mention, “melatonin is tied to your circadian rhythm, and anything that relates to the timing of your body can be affected when you take it,” says Winter. Timing matters here because if your body isn’t on the right sleep schedule (i.e. you’re taking the melatonin late and still waking up early), you could end up waking up during deeper REM sleep, which would leave you feeling headachy. ## Gastrointestinal Issues Nausea, constipation, and an upset stomach are all common reactions to medication, and could come with taking melatonin. “The ingredients in a drug or supplement can change—even what’s holding the tablet or the capsule together—and that could cause irritation in your GI system,” says Salas. She often warns her patients to avoid buying melatonin in bulk until their know how their body is going to react. “You might have GI effects with one brand versus another, so it’s worth waiting to see what happens before committing to a specific supplement.” ![Headshot of Ashley Mateo](data:image/svg+xml;utf8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201024%201024'%3E%3Crect%20width%3D'100%25'%20height%3D'100%25'%20fill%3D'%23f3f3f3'%2F%3E%3Cg%20fill%3D'none'%20stroke%3D'%23545454'%20stroke-linecap%3D'round'%20stroke-width%3D'18'%3E%3Ccircle%20cx%3D'512'%20cy%3D'310'%20r%3D'97'%2F%3E%3Cpath%20d%3D'm444%20245%20132%20133'%2F%3E%3C%2Fg%3E%3Cg%20fill%3D'%23545454'%20font-family%3D'Arial%2CHelvetica%2Csans-serif'%20font-size%3D'98'%20font-weight%3D'600'%20text-anchor%3D'middle'%3E%3Ctext%20x%3D'514'%20y%3D'535'%3EIMAGE%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'643'%3EFAILED%3C%2Ftext%3E%3Ctext%20x%3D'514'%20y%3D'747'%3ETO%20LOAD%3C%2Ftext%3E%3C%2Fg%3E%3C%2Fsvg%3E) Ashley Mateo is a writer, editor, and UESCA- and RRCA-certified running coach who has contributed to Runner’s World, Bicycling, Women's Health, Health, Shape, Self, and more. She’ll go anywhere in the world once—even if it’s just for a good story. Also into: good pizza, good beer, and good photos.
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