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/æntaɪdɪˈprɛsənt/
/æntaɪdɪˈprɛsənt/
IPA guide
Other forms:
antidepressants
An
antidepressant
is a drug used to treat depression. Unfortunately, many
antidepressants
have unwanted side effects.
Depression is a form of extreme sadness, when you're so sad that it impairs your ability to function. Words starting with
anti
are the opposite or go against other things. Antidepressants, then, are drugs that fight depression. If you’re depressed, a doctor can prescribe an antidepressant such as Prozac or Zoloft. Antidepressants can improve your mood, but they often have side effects such as weight gain or headaches.
Definitions of
antidepressant
noun
any of a class of drugs used to treat depression; often have undesirable side effects
see more
see less
types:
MAOI
,
monoamine oxidase inhibitor
any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
maleate
a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation
desipramine
a tricyclic antidepressant drug that activates the psychomotor system
Prozac
,
Sarafem
,
fluoxetine
,
fluoxetine hydrocholoride
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain
iproclozide
an antidepressant drug that acts as a monoamine oxidase inhibitor
Marplan
,
isocarboxazid
a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
Pamelor
,
nortriptyline
a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
Paxil
,
paroxetime
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Paxil)
Nardil
,
phenelzine
monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
protriptyline
tricyclic antidepressant used to treat clinical depression
Zoloft
,
sertraline
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft)
tranylcypromine
an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
Surmontil
,
trimipramine
tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
type of:
Style:
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MLA
APA
Chicago
"Antidepressant."
Vocabulary.com Dictionary,
Vocabulary.com, https://www.vocabulary.com/dictionary/antidepressant. Accessed 11 Apr. 2026.
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# antidepressant
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/æntaɪdɪˈprɛsənt/
/æntaɪdɪˈprɛsənt/
[IPA guide](https://www.vocabulary.com/resources/ipa-pronunciation/)
Other forms: **antidepressants**
An *antidepressant* is a drug used to treat depression. Unfortunately, many *antidepressants* have unwanted side effects.
Depression is a form of extreme sadness, when you're so sad that it impairs your ability to function. Words starting with *anti* are the opposite or go against other things. Antidepressants, then, are drugs that fight depression. If you’re depressed, a doctor can prescribe an antidepressant such as Prozac or Zoloft. Antidepressants can improve your mood, but they often have side effects such as weight gain or headaches.
Definitions of antidepressant
1. noun
any of a class of drugs used to treat depression; often have undesirable side effects
synonyms: [antidepressant drug](https://www.vocabulary.com/dictionary/antidepressant%20drug)
[see moresee less](https://www.vocabulary.com/dictionary/antidepressant#0)
types:
[show 23 types...]()
[hide 23 types...]()
[MAOI](https://www.vocabulary.com/dictionary/MAOI), [monoamine oxidase inhibitor](https://www.vocabulary.com/dictionary/monoamine%20oxidase%20inhibitor)
any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
[Serzone](https://www.vocabulary.com/dictionary/Serzone), [nefazodone](https://www.vocabulary.com/dictionary/nefazodone)
an antidepressant drug (trade name Serzone)
[nontricyclic](https://www.vocabulary.com/dictionary/nontricyclic), [nontricyclic antidepressant](https://www.vocabulary.com/dictionary/nontricyclic%20antidepressant), [nontricyclic antidepressant drug](https://www.vocabulary.com/dictionary/nontricyclic%20antidepressant%20drug), [nontricyclic drug](https://www.vocabulary.com/dictionary/nontricyclic%20drug)
a class of antidepressant drugs that are not tricyclic drugs and do not act by inhibiting MAO
[Edronax](https://www.vocabulary.com/dictionary/Edronax), [reboxetine](https://www.vocabulary.com/dictionary/reboxetine)
an antidepressant drug that blocks the reuptake of norepinephrine
[SSRI](https://www.vocabulary.com/dictionary/SSRI), [selective-serotonin reuptake inhibitor](https://www.vocabulary.com/dictionary/selective-serotonin%20reuptake%20inhibitor)
an antidepressant drug that acts by blocking the reuptake of serotonin so that more serotonin is available to act on receptors in the brain
[tricyclic](https://www.vocabulary.com/dictionary/tricyclic), [tricyclic antidepressant](https://www.vocabulary.com/dictionary/tricyclic%20antidepressant), [tricyclic antidepressant drug](https://www.vocabulary.com/dictionary/tricyclic%20antidepressant%20drug)
an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain
[maleate](https://www.vocabulary.com/dictionary/maleate)
a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation
[Elavil](https://www.vocabulary.com/dictionary/Elavil), [amitriptyline](https://www.vocabulary.com/dictionary/amitriptyline), [amitriptyline hydrochloride](https://www.vocabulary.com/dictionary/amitriptyline%20hydrochloride)
a tricyclic antidepressant drug (trade name Elavil) with serious side effects; interacts with many other medications
[clomipramine](https://www.vocabulary.com/dictionary/clomipramine)
a tricyclic antidepressant drug
[desipramine](https://www.vocabulary.com/dictionary/desipramine)
a tricyclic antidepressant drug that activates the psychomotor system
[Adapin](https://www.vocabulary.com/dictionary/Adapin), [Sinequan](https://www.vocabulary.com/dictionary/Sinequan), [doxepin](https://www.vocabulary.com/dictionary/doxepin), [doxepin hydrochloride](https://www.vocabulary.com/dictionary/doxepin%20hydrochloride)
a tricyclic antidepressant (trade names Adapin and Sinequan) with numerous side effects (dry mouth and sedation and gastrointestinal disturbances)
[Prozac](https://www.vocabulary.com/dictionary/Prozac), [Sarafem](https://www.vocabulary.com/dictionary/Sarafem), [fluoxetine](https://www.vocabulary.com/dictionary/fluoxetine), [fluoxetine hydrocholoride](https://www.vocabulary.com/dictionary/fluoxetine%20hydrocholoride)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain
[Imavate](https://www.vocabulary.com/dictionary/Imavate), [Tofranil](https://www.vocabulary.com/dictionary/Tofranil), [imipramine](https://www.vocabulary.com/dictionary/imipramine), [impramine hydrochloride](https://www.vocabulary.com/dictionary/impramine%20hydrochloride)
a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
[iproclozide](https://www.vocabulary.com/dictionary/iproclozide)
an antidepressant drug that acts as a monoamine oxidase inhibitor
[Marplan](https://www.vocabulary.com/dictionary/Marplan), [isocarboxazid](https://www.vocabulary.com/dictionary/isocarboxazid)
a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
[Pamelor](https://www.vocabulary.com/dictionary/Pamelor), [nortriptyline](https://www.vocabulary.com/dictionary/nortriptyline)
a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
[Paxil](https://www.vocabulary.com/dictionary/Paxil), [paroxetime](https://www.vocabulary.com/dictionary/paroxetime)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Paxil)
[Nardil](https://www.vocabulary.com/dictionary/Nardil), [phenelzine](https://www.vocabulary.com/dictionary/phenelzine)
monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
[protriptyline](https://www.vocabulary.com/dictionary/protriptyline)
tricyclic antidepressant used to treat clinical depression
[Zoloft](https://www.vocabulary.com/dictionary/Zoloft), [sertraline](https://www.vocabulary.com/dictionary/sertraline)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft)
[tranylcypromine](https://www.vocabulary.com/dictionary/tranylcypromine)
an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
[Desyrel](https://www.vocabulary.com/dictionary/Desyrel), [trazodone](https://www.vocabulary.com/dictionary/trazodone), [trazodone hydrochloride](https://www.vocabulary.com/dictionary/trazodone%20hydrochloride)
oral antidepressant (trade name Desyrel) that is a nontricyclic drug used as a sedative
[Surmontil](https://www.vocabulary.com/dictionary/Surmontil), [trimipramine](https://www.vocabulary.com/dictionary/trimipramine)
tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
type of:
[medicament](https://www.vocabulary.com/dictionary/medicament), [medication](https://www.vocabulary.com/dictionary/medication), [medicinal drug](https://www.vocabulary.com/dictionary/medicinal%20drug), [medicine](https://www.vocabulary.com/dictionary/medicine)
(medicine) something that treats or prevents or alleviates the symptoms of disease
Cite this entry
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DISCLAIMER: These example sentences appear in various news sources and books to reflect the usage of the word **‘antidepressant'**. Views expressed in the examples do not represent the opinion of [Vocabulary.com](https://www.vocabulary.com/) or its editors. [Send us feedback](https://www.ixl.com/feedback/vocabularydotcom)
Word Family
- [antidepressant](https://www.vocabulary.com/dictionary/antidepressant)[antidepressants](https://www.vocabulary.com/dictionary/antidepressants)
- [depressant](https://www.vocabulary.com/dictionary/depressant)[depressants](https://www.vocabulary.com/dictionary/depressants)[antidepressant](https://www.vocabulary.com/dictionary/antidepressant)
- [depress](https://www.vocabulary.com/dictionary/depress)[depressed](https://www.vocabulary.com/dictionary/depressed)[depressing](https://www.vocabulary.com/dictionary/depressing)[depresses](https://www.vocabulary.com/dictionary/depresses)[depression](https://www.vocabulary.com/dictionary/depression)[depressive](https://www.vocabulary.com/dictionary/depressive)[depressant](https://www.vocabulary.com/dictionary/depressant)[depressor](https://www.vocabulary.com/dictionary/depressor)
- [the "depress" family](https://www.vocabulary.com/dictionary/depress)
### Vocabulary lists containing **antidepressant**
[Prefixes: anti-](https://www.vocabulary.com/lists/190360)
The prefix "anti-" means "against," "in opposition to," or "opposite of."
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| Readable Markdown | [SKIP TO CONTENT](https://www.vocabulary.com/dictionary/antidepressant#hdr-word-area)
/æntaɪdɪˈprɛsənt/
/æntaɪdɪˈprɛsənt/
[IPA guide](https://www.vocabulary.com/resources/ipa-pronunciation/)
Other forms: **antidepressants**
An *antidepressant* is a drug used to treat depression. Unfortunately, many *antidepressants* have unwanted side effects.
Depression is a form of extreme sadness, when you're so sad that it impairs your ability to function. Words starting with *anti* are the opposite or go against other things. Antidepressants, then, are drugs that fight depression. If you’re depressed, a doctor can prescribe an antidepressant such as Prozac or Zoloft. Antidepressants can improve your mood, but they often have side effects such as weight gain or headaches.
Definitions of antidepressant
1. noun
any of a class of drugs used to treat depression; often have undesirable side effects
[see moresee less](https://www.vocabulary.com/dictionary/antidepressant#0)
types:
[MAOI](https://www.vocabulary.com/dictionary/MAOI), [monoamine oxidase inhibitor](https://www.vocabulary.com/dictionary/monoamine%20oxidase%20inhibitor)
any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
[maleate](https://www.vocabulary.com/dictionary/maleate)
a salt or ester of maleic acid; used as a nontricyclic antidepressant drug for psychomotor activation
[desipramine](https://www.vocabulary.com/dictionary/desipramine)
a tricyclic antidepressant drug that activates the psychomotor system
[Prozac](https://www.vocabulary.com/dictionary/Prozac), [Sarafem](https://www.vocabulary.com/dictionary/Sarafem), [fluoxetine](https://www.vocabulary.com/dictionary/fluoxetine), [fluoxetine hydrocholoride](https://www.vocabulary.com/dictionary/fluoxetine%20hydrocholoride)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade names Prozac or Sarafem); it is thought to work by increasing the activity of serotonin in the brain
[iproclozide](https://www.vocabulary.com/dictionary/iproclozide)
an antidepressant drug that acts as a monoamine oxidase inhibitor
[Marplan](https://www.vocabulary.com/dictionary/Marplan), [isocarboxazid](https://www.vocabulary.com/dictionary/isocarboxazid)
a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
[Pamelor](https://www.vocabulary.com/dictionary/Pamelor), [nortriptyline](https://www.vocabulary.com/dictionary/nortriptyline)
a tricyclic antidepressant drug (trade name Pamelor) used along with psychotherapy to treat dysthymic depression; may interact dangerously if taken with other drugs
[Paxil](https://www.vocabulary.com/dictionary/Paxil), [paroxetime](https://www.vocabulary.com/dictionary/paroxetime)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Paxil)
[Nardil](https://www.vocabulary.com/dictionary/Nardil), [phenelzine](https://www.vocabulary.com/dictionary/phenelzine)
monoamine oxidase inhibitor (trade name Nardil) used to treat clinical depression
[protriptyline](https://www.vocabulary.com/dictionary/protriptyline)
tricyclic antidepressant used to treat clinical depression
[Zoloft](https://www.vocabulary.com/dictionary/Zoloft), [sertraline](https://www.vocabulary.com/dictionary/sertraline)
a selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft)
[tranylcypromine](https://www.vocabulary.com/dictionary/tranylcypromine)
an antidepressant drug that is a monoamine oxidase inhibitor; administered as a sulfate
[Surmontil](https://www.vocabulary.com/dictionary/Surmontil), [trimipramine](https://www.vocabulary.com/dictionary/trimipramine)
tricyclic antidepressant drug (trade name Surmontil) used to treat depression and anxiety and (sometimes) insomnia
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"Antidepressant." *Vocabulary.com Dictionary,* Vocabulary.com, https://www.vocabulary.com/dictionary/antidepressant. Accessed 11 Apr. 2026.
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| Shard | 177 (laksa) |
| Root Hash | 5066149262321948577 |
| Unparsed URL | com,vocabulary!www,/dictionary/antidepressant s443 |