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1. Shard Calculation

Query:

Response:

Calculated Shard: 157 (from laksa190)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa157.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical, ml_categories_json AS ml_categories_json, ml_types_json AS ml_types_json, ml_intent_types_json AS ml_intent_types_json, meta_language AS meta_language, attrs_author AS attrs_author, ifNull(toUnixTimestamp(attrs_publish_time), 0) AS attrs_publish_time, ifNull(toUnixTimestamp(attrs_original_publish_time), 0) AS attrs_original_publish_time, ifNull(attrs_is_republished, 0) AS attrs_is_republished, ifNull(attrs_nr_words, 0) AS attrs_nr_words, ifNull(attrs_boilerpipe_nr_words, 0) AS attrs_boilerpipe_nr_words, ifNull(body_ext_links_number, 0) AS body_ext_links_number, ifNull(body_int_links_number, 0) AS body_int_links_number, ifNull(meta_nofollow, 0) AS meta_nofollow, ifNull(meta_noarchive, 0) AS meta_noarchive, ifNull(props_was_rendered, 0) AS props_was_rendered, ifNull(src_redirect, \'\') AS src_redirect, ifNull(download_time_msec, 0) AS download_time_msec, ifNull(download_ttfb_msec, 0) AS download_ttfb_msec, ifNull(download_size, 0) AS download_size FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.verywellmind.com/over-the-counter-antidepressants-1066678\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.verywellmind.com/over-the-counter-antidepressants-1066678\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678","crawl_time":1777010979,"first_indexed_time":1520088728,"http_code":200,"src_unparsed":"com,verywellmind!www,\/over-the-counter-antidepressants-1066678 s443","src_root_hash":"10064058272378209957","history_drop_reason":null,"meta_title":"Over-the-Counter Antidepressants","meta_descriptions":["If you're coping with mild depression symptoms, over-the-counter antidepressant medications may provide some relief. Learn more."],"attrs_boilerpipe_text":"By\nNancy Schimelpfening\nNancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.\nUpdated on February 17, 2026\nMedically reviewed\nVerywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates.\nLearn more\n.\nby\nDaniel B. Block, MD\nDaniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania.\nKey Takeaways\nSt. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use.\nOmega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval.\n5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications.\nAntidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression.\nThese OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management.\nSt. John's Wort.\nesemelwe\/Getty Images\nWhat Are Over-the-Counter Antidepressants?\nOver-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include:\nSt. John's wort\nOmega-3 fatty acids\n5-HTP\nSAMe\nRhodiola rosea\nVitamins and minerals like vitamin D and magnesium\nOver-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants.\nSt. John's Wort\nSt. John's wort\nhas a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world.\nDoes St. John's Wort Work For Depression?\nThere is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects.\nThe review also noted, however, that the evidence isn't strong enough to make a \"robust conclusion.\"\nThe National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment.\nHow Much St. John's Wort Do You Need?\nDosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product.\nWhat to Be Aware Of\nIf you take St. John's wort, it's important to be aware of:\nSide effects\n: Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion.\nDrug interactions\n: Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person.\nSerotonin syndrome\n: If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other\nmedication that increases serotonin\n, there is a risk for\nserotonin syndrome\n, which can be fatal. \nSun sensitivity\n: St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen.\nOmega-3 Fatty Acids\nSharaff \/ Getty Images\nOmega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health.\nThere are three types of omega-3s:\nAlpha-linolenic acid (ALA)\nEicosapentaenoic acid (EPA)\nDocosahexaenoic acid (DHA)\nDo Omega-3 Fatty Acids Work For Depression?\nMore research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression.\n \nEPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits.\nA 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression.\nWhile omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes.\nHow Much Omega-3 Do You Need?\nMost Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA.\nYou can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk.\nNo particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding.\nHow to Get More Omega-3s\nSince our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements.\nFoods that are high in omega-3s include:\nFish (especially salmon, mackerel, tuna, sardines, and herring)\nNuts and seeds (including walnuts, chia seeds, and flax seeds)\nPlant oils (including canola oil, soybean oil, and flaxseed oil)\nWhat to Be Aware Of\nIf you decide to try taking supplemental omega-3s, there are a few things to be aware of:\nStomach upset\n: While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses.\nIncreased blood thinning\n: Omega-3 supplements may increase the effects of blood-thinning medications.\nFor those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health,\nwhich could be taken as a good minimum consumption level.\n5-HTP\nJynto \/ Wikimedia Commons \/ CC0\n5-HTP\n, or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase\nserotonin\n, a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression.\n5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of\nGriffonia simplicifolia,\na plant native to Central and Western Africa\n.\nThe body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase.\nTaking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin.\nDoes 5-HTP Work For Depression?\nWhile better-quality studies are needed to firmly establish its\neffectiveness as an antidepressant\n, a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases.\nHowever, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program.\nHow Much 5-HTP Do You Need?\nIn clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day.\nHowever, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs.\nWhat to Be Aware Of\n5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include:\nDiarrhea\nDizziness\nDrowsiness\nFeelings of anxiety\nMuscular tenderness\nNausea\nSexual dysfunction\n5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM).\n5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin.\nSAMe\nNEUROtiker \/ Wikimedia Commons \/ Public Domain\nSAMe\n(S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement.\nSAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression.\nDoes SAMe Work For Depression?\nStudies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants.\nHow Much SAMe Do You Need?\nFollow the package directions or consult with your physician for an appropriate dose for you.\nWhat to Be Aware Of\nPotential side effects include:\nDizziness\nElevated levels of homocysteine (a protein that has been linked to cardiovascular problems)\nGastrointestinal symptoms\nLoss of appetite\nProblems sleeping\nIt is also important to note that SAMe may worsen\nsymptoms of mania\nin people with bipolar disorder.\nRhodiola Rosea\nDaderot \/ Wikimedia Commons \/ Public Domain\nAlthough not much English-language research is currently available on\nRhodiola rosea\n, it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress.\nDoes Rhodiola Rosea Work For Depression?\nAccording to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use.\nOne 2018 study found that Rhodiola rosea extract helped improve symptoms of\nstress-related burnout\n, including depression.\n \nWhile American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record.\nHow Much Rhodiola Rosea Do You Need?\nIn clinical studies, doses range from 100 mg to 400 mg daily.\nHowever, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations.\nWhat to Be Aware Of\nAt low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications:\nAnti-anxiety medication\nPrescription antidepressants\nAntibiotics\nThyroid medication\nMedications to treat diabetes\nBirth control pills\nVitamins and Minerals\nBrian Hagiwara Photolibrary \/ Getty Images\nA wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12,\nchromium\n, and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression.\nDo Vitamins and Minerals Work For Depression?\nOne meta-analysis suggested that the typical Western diet (which includes larger amounts of red\/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression.\nHealthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression.\nHow Many Vitamins and Minerals Do You Need?\nIn general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance.\nAlternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency.\nWhat to Be Aware Of\nA\nhealthy diet\nis always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and\/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step.\nBefore Taking Over-the-Counter Antidepressants\nThere are a few things to remember before you decide to try over-the-counter antidepressants:\nThey don't replace other treatments.\nDon't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy.\nThey can cause interactions\n. Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking.\nTheir quality can vary\n. Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another.\nPrescription vs. Over-the-Counter Antidepressants\nIt's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants.\nSupplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled.\nPrescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression.\nPrescription Antidepressants\nExamples include Prozac, Zoloft, and Cymbalta\nFDA-approved (although some may be used off-label)\nStrong evidence of efficacy\nStandardized doses\nBest for moderate to severe depression\nOTC Antidepressants\nExamples include St. John's wort, SAMe, and 5-HTP\nNot FDA-approved for depression\nLimited to moderate evidence of efficacy\nVaries by brand\nBest for mild to moderate depression\nSeeking Professional Help\nIf you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication.\nTherapy\nYour doctor may recommend that you attend therapy.\nCognitive behavioral therapy\n(CBT) is a common therapy type used to treat depression.\nDuring CBT, a therapist will help you reframe negative thoughts and behaviors and teach you\nhealthy coping mechanisms\nto help alleviate symptoms of depression.\nMedication\nIn order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a\nselective serotonin reuptake inhibitor\n(SSRI).\nSSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood.\nExamples of SSRIs include:\nTrintellix (vortioxetine)\nZoloft\n(sertraline)\nProzac\n(fluoxetine)\nLexapro\n(escitalopram)\nOr, a doctor may prescribe a\nserotonin-norepinephrine reuptake inhibitor\n(SNRI) such as\nEffexor\n(venlafaxine).\nSSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness.\nBe sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression.\n23 Sources\nVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our\neditorial process\nto learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.\nZirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A.\nHypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action\n.\nJ Cell Physiol\n. 2019;234(6):8496-8508. doi:10.1002\/jcp.27781\nNational Center for Complementary and Integrative Health.\nSt. John's wort and depression: In-depth\n.\nde Wit L, Jeurissen S,\nChen W. Risk assessment of herbal preparations containing St John's wort\n. National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019.\nWani AL, Bhat SA, Ara A.\nOmega-3 fatty acids and the treatment of depression: A review of scientific evidence\n. \nIntegr Med Res\n. 2015;4(3):132-141. doi:10.1016\/j.imr.2015.07.003\nLiao Y, Xie B, Zhang H, et al.\nEfficacy of omega-3 PUFAs in depression: A meta-analysis\n. \nTransl Psychiatry\n. 2019;9(1):190. doi:10.1038\/s41398-019-0515-5\nBurhani MD, Rasenick MM.\nFish oil and depression: The skinny on fats\n. \nJ Integr Neurosci\n. 2017;16(s1):S115-S124. doi:10.3233\/JIN-170072\nNational Institutes of Health Office of Dietary Supplements.\nOmega-3 fatty acids: Fact sheet for consumers\n.\nNational Institutes of Health Office of Dietary Supplements.\nOmega-3 fatty acids: Fact sheet for health professionals\n.\nAmerican Heart Association.\nFish and omega-3 fatty acids\n.\nMaffei ME.\n5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology\n.\nInt J Mol Sci\n. 2020;22(1):181. doi:10.3390\/ijms22010181\nDome P, Tombor L, Lazary J, Gonda X, Rihmer Z.\nNatural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review\n.\nBrain Res Bull\n. 2019;146:51-78. doi:10.1016\/j.brainresbull.2018.12.015\nJavelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P.\nEffects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis\n.\nNutr Rev\n. 2020;78(1):77-88. doi:10.1093\/nutrit\/nuz039\nNational Center for Complementary and Integrative Health.\nS-adenosyl-l-methionine (SAMe): in depth\n.\nJagtap PN, Mhetre OS, Malavdkar PR.\nA review article on Rhodiola rosea: An adaptogen having multiple benefits\n.\nInt J Pharmacogn\n. 2020;7:62-9.\nAmsterdam JD, Panossian AG.\nRhodiola rosea L. as a putative botanical antidepressant\n.\nPhytomedicine\n. 2016;23(7):770-83. doi:10.1016\/j.phymed.2016.02.009\nKasper S, Dienel A.\nMulticenter, open-label, exploratory clinical trial with \nRhodiola rosea\n extract in patients suffering from burnout symptoms\n. \nNeuropsychiatr Dis Treat\n. 2017;13:889-898. doi:10.2147\/NDT.S120113\nLi Y, Lv MR, Wei YJ, et al.\nDietary patterns and depression risk: A meta-analysis\n.\nPsychiatry Res\n. 2017;253:373-382. doi:10.1016\/j.psychres.2017.04.020\nU.S. Department of Health and Human Services and U.S. Department of Agriculture.\n2015 – 2020 Dietary Guidelines for Americans. 8th Edition\n.\nU.S. Food and Drug Administration.\nDepression medicines\n.\nGautam M, Tripathi A, Deshmukh D, Gaur M.\nCognitive behavioral therapy for depression\n. \nIndian J Psychiatry\n. 2020;62(Suppl 2):S223-S229. doi:10.4103\/psychiatry.IndianJPsychiatry_772_19\nClevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW.\nThe role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder\n. \nTher Adv Psychopharmacol\n. 2018;8(1):49-58. doi:10.1177\/2045125317737264\nSansone RA, Sansone LA.\nSerotonin norepinephrine reuptake inhibitors: a pharmacological comparison\n. \nInnov Clin Neurosci\n. 2014;11(3-4):37-42.\nSantarsieri D, Schwartz TL.\nAntidepressant efficacy and side-effect burden: a quick guide for clinicians\n. \nDrugs Context\n. 2015;4:212290. doi:10.7573\/dic.212290\nBy\nNancy Schimelpfening\nNancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.  \nWas this page helpful?\nThanks for your feedback!\nWhat is your feedback?","attrs_markdown":"[Skip to content](https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678#skip-to-content)\n\nMenu\n\n- [Conditions A-Z](https:\/\/www.verywellmind.com\/conditions-a-z-4797402)\n  - [Addiction](https:\/\/www.verywellmind.com\/addiction-overview-4581803)\n  - [Depression](https:\/\/www.verywellmind.com\/depression-4157261)\n  - [ADHD](https:\/\/www.verywellmind.com\/adhd-overview-4581801)\n  - [Anxiety](https:\/\/www.verywellmind.com\/anxiety-7508391)\n  - [Bipolar Disorder](https:\/\/www.verywellmind.com\/bipolar-disorder-4157274)\n  - [PTSD](https:\/\/www.verywellmind.com\/ptsd-4157229)\n  - [View All](https:\/\/www.verywellmind.com\/conditions-a-z-4797402)\n- [Therapy](https:\/\/www.verywellmind.com\/therapy-4581775)\n  - [Therapy Center](https:\/\/www.verywellmind.com\/therapy-7092217)\n  - 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[Types of Therapy](https:\/\/www.verywellmind.com\/how-to-choose-the-best-type-of-therapy-for-you-6500320)\n  - [Best Online Therapy](https:\/\/www.verywellmind.com\/best-online-therapy-4691206)\n  - [Best Couples Therapy](https:\/\/www.verywellmind.com\/best-online-marriage-counseling-4691952)\n  - [View All](https:\/\/www.verywellmind.com\/therapy-4581775)\n- [Living Well](https:\/\/www.verywellmind.com\/living-well-7510832)\n  - [Managing Stress](https:\/\/www.verywellmind.com\/stress-management-overview-4581770)\n  - [Meditation](https:\/\/www.verywellmind.com\/meditation-and-mindfulness-4581783)\n  - [Sleep and Dreaming](https:\/\/www.verywellmind.com\/sleep-and-dreaming-4157166)\n  - [Understanding Emotions](https:\/\/www.verywellmind.com\/emotions-4157165)\n  - [Self-Improvement](https:\/\/www.verywellmind.com\/self-improvement-4157212)\n  - [View All](https:\/\/www.verywellmind.com\/living-well-7510832)\n- [Relationships](https:\/\/www.verywellmind.com\/relationships-4157190)\n  - [Healthy Relationships](https:\/\/www.verywellmind.com\/strengthening-relationships-4162997)\n  - [Dating](https:\/\/www.verywellmind.com\/dating-tips-and-strategies-7511571)\n  - [Intimacy](https:\/\/www.verywellmind.com\/sex-and-relationships-7511610)\n  - [View All](https:\/\/www.verywellmind.com\/relationships-4157190)\n- [Psychology](https:\/\/www.verywellmind.com\/psychology-4157187)\n  - [Theories](https:\/\/www.verywellmind.com\/theories-of-psychology-4157184)\n  - [Student Resources](https:\/\/www.verywellmind.com\/student-resources-overview-4581768)\n  - [Personality Types](https:\/\/www.verywellmind.com\/the-myers-briggs-type-indicator-2795583)\n  - [View All](https:\/\/www.verywellmind.com\/psychology-4157187)\n- [Trending](https:\/\/www.verywellmind.com\/news-latest-research-and-trending-topics-4846421)\n  - [Quizzes](https:\/\/www.verywellmind.com\/quizzes-8609222)\n  - [Guided Meditations](https:\/\/www.verywellmind.com\/guided-meditations-8609227)\n  - [Verywell Mind Insights](https:\/\/www.verywellmind.com\/mental-health-data-insights-5185693)\n  - [2024 Verywell Mind 25](https:\/\/www.verywellmind.com\/the-verywell-mind-25-2024-7484480)\n  - [Mental Health in the Classroom](https:\/\/www.verywellmind.com\/mental-health-in-the-classroom-survey-7569880)\n  - [View All](https:\/\/www.verywellmind.com\/news-latest-research-and-trending-topics-4846421)\n\n[More in Depression](https:\/\/www.verywellmind.com\/depression-4157261)\n\n- [Treatment](https:\/\/www.verywellmind.com\/depression-treatment-4157258)\n- [Living With](https:\/\/www.verywellmind.com\/living-with-depression-7508413)\n- [Causes](https:\/\/www.verywellmind.com\/depression-causes-4157256)\n- [Symptoms and Diagnosis](https:\/\/www.verywellmind.com\/depression-symptoms-and-diagnosis-4157260)\n- [Types](https:\/\/www.verywellmind.com\/depression-types-4157254)\n- [Childhood Depression](https:\/\/www.verywellmind.com\/childhood-depression-4157255)\n- [Suicide](https:\/\/www.verywellmind.com\/suicide-4157253)\n\n[View More](https:\/\/www.verywellmind.com\/depression-4157261)\n\n- [About Us](https:\/\/www.verywellmind.com\/about-us-5184564)\n- [Editorial Process](https:\/\/www.verywellmind.com\/our-editorial-process-4778006)\n- [Review Board](https:\/\/www.verywellmind.com\/review-board-4796494)\n- [Crisis Support](https:\/\/www.verywellmind.com\/crisis-support-6666353)\n\nVerywell Mind's content is for informational and educational purposes only. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment.\n\nⒸ 2026 People Inc. — All rights reserved\n\n# Over-the-Counter Antidepressants\nBy\n\n[Nancy Schimelpfening](https:\/\/www.verywellmind.com\/nancy-schimelpfening-ms-4781235)\n\n[Nancy Schimelpfening](https:\/\/www.verywellmind.com\/nancy-schimelpfening-ms-4781235)\n\nNancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.\n\nLearn about our  [editorial process](https:\/\/www.verywellmind.com\/our-editorial-process-4778006)\n\nUpdated on February 17, 2026\n\nMedically reviewed\n\nVerywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. [Learn more](https:\/\/www.verywellmind.com\/review-board-4796494).\n\nby\n\n[Daniel B. Block, MD](https:\/\/www.verywellmind.com\/daniel-block-md-4779186)\n\n![Block]()\n\n![Block](https:\/\/www.verywellmind.com\/thmb\/bqppKq4IVUTVsPMClzJADd5fs14=\/200x200\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/block-8924ca72ff94426d940e8f7e639e3942.jpg)\n\nMedically reviewed by [Daniel B. Block, MD](https:\/\/www.verywellmind.com\/daniel-block-md-4779186)\n\nDaniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania.\n\nLearn about our  [Medical Review Board](https:\/\/www.verywellmind.com\/review-board-4796494)\n\nTable of Contents\n\nView All\n\nTable of Contents\n\n- [What Are OTC Antidepressants?](https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678#toc-what-are-over-the-counter-antidepressants)\n- [Things to Know](https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678#toc-before-taking-over-the-counter-antidepressants)\n- [Prescription vs. OTC](https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678#toc-prescription-vs-over-the-counter-antidepressants)\n- [Seeking Professional Help](https:\/\/www.verywellmind.com\/over-the-counter-antidepressants-1066678#toc-seeking-professional-help)\n\nClose\n\n### Key Takeaways\n- St. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use.\n- Omega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval.\n- 5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications.\n\nAntidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression.\n\nThese OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management.\n\n![Closeup of blooming St Johns wort flowers]()\n\n![Closeup of blooming St Johns wort flowers](https:\/\/www.verywellmind.com\/thmb\/p_B45Mc-WZIQKt_elJyI9uyT2Fw=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/st-johns-wort-56af35893df78cf772c1933f.jpg)\n\nSt. John's Wort. esemelwe\/Getty Images\n## What Are Over-the-Counter Antidepressants?\nOver-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include:\n\n- St. John's wort\n- Omega-3 fatty acids\n- 5-HTP\n- SAMe\n- Rhodiola rosea\n- Vitamins and minerals like vitamin D and magnesium\n\nOver-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants.\n\n## St. John's Wort\n[St. John's wort](https:\/\/www.verywellmind.com\/st-johns-wort-a2-89959) has a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world.\n\n### Does St. John's Wort Work For Depression?\nThere is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects. The review also noted, however, that the evidence isn't strong enough to make a \"robust conclusion.\"\n\nThe National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment.\n\n### How Much St. John's Wort Do You Need?\nDosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product.\n\n### What to Be Aware Of\nIf you take St. John's wort, it's important to be aware of:\n\n- **Side effects**: Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion.\n- **Drug interactions**: Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person.\n- **Serotonin syndrome**: If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other [medication that increases serotonin](https:\/\/www.verywellmind.com\/medications-and-serotonin-syndrome-2584342), there is a risk for [serotonin syndrome](https:\/\/www.verywellmind.com\/what-is-serotonin-syndrome-379651), which can be fatal.\n- **Sun sensitivity**: St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen.\n\n## Omega-3 Fatty Acids\n![Oil capsules spilling out of a bottle]()\n\n![Oil capsules spilling out of a bottle](https:\/\/www.verywellmind.com\/thmb\/dJObspOd5H80ZjlyuxK0Vkv3qhk=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/fish-oil-capsules-56af37513df78cf772c1a840.jpg)\n\nSharaff \/ Getty Images\n\nOmega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health.\n\nThere are three types of omega-3s:\n\n- Alpha-linolenic acid (ALA)\n- Eicosapentaenoic acid (EPA)\n- Docosahexaenoic acid (DHA)\n### Do Omega-3 Fatty Acids Work For Depression?\nMore research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression.\n\n- EPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits.\n- A 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression.\n\nWhile omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes.\n\n### How Much Omega-3 Do You Need?\nMost Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA. You can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk.\n\nNo particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding.\n\n### How to Get More Omega-3s\nSince our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements.\n\nFoods that are high in omega-3s include:\n\n- Fish (especially salmon, mackerel, tuna, sardines, and herring)\n- Nuts and seeds (including walnuts, chia seeds, and flax seeds)\n- Plant oils (including canola oil, soybean oil, and flaxseed oil)\n### What to Be Aware Of\nIf you decide to try taking supplemental omega-3s, there are a few things to be aware of:\n\n- **Stomach upset**: While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses.\n- **Increased blood thinning**: Omega-3 supplements may increase the effects of blood-thinning medications.\n\nFor those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health, which could be taken as a good minimum consumption level.\n\n## 5-HTP\n![Chemical model]()\n\n![Chemical model](https:\/\/www.verywellmind.com\/thmb\/amUSi9yxYB25WK0oNJjbuZttSeI=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/5-htp-56af37535f9b58b7d0160c21.png)\n\nJynto \/ Wikimedia Commons \/ CC0\n\n[5-HTP](https:\/\/www.verywellmind.com\/5-htp-5-hydroxytryptophan-88320), or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase [serotonin](https:\/\/www.verywellmind.com\/what-is-serotonin-425327), a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression.\n\n5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of *Griffonia simplicifolia,* a plant native to Central and Western Africa*.*\n\nThe body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase. Taking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin.\n\n### Does 5-HTP Work For Depression?\nWhile better-quality studies are needed to firmly establish its [effectiveness as an antidepressant](https:\/\/www.verywellmind.com\/5-htp-for-depression-1066521), a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases. However, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program.\n\n### How Much 5-HTP Do You Need?\nIn clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day. However, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs.\n\n### What to Be Aware Of\n5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include:\n\n- Diarrhea\n- Dizziness\n- Drowsiness\n- Feelings of anxiety\n- Muscular tenderness\n- Nausea\n- Sexual dysfunction\n\n5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM).\n\n5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin.\n\n## SAMe\n![Chemical formula]()\n\n![Chemical formula](https:\/\/www.verywellmind.com\/thmb\/mdWTy2J7UPtNb5lw3hNZB6_dnMk=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/same-56af37555f9b58b7d0160c2e.png)\n\nNEUROtiker \/ Wikimedia Commons \/ Public Domain\n\n[SAMe](https:\/\/www.verywellmind.com\/how-sam-e-can-benefit-mental-health-6745925) (S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement.\n\nSAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression.\n\n### Does SAMe Work For Depression?\nStudies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants.\n\n### How Much SAMe Do You Need?\nFollow the package directions or consult with your physician for an appropriate dose for you.\n\n### What to Be Aware Of\nPotential side effects include:\n\n- Dizziness\n- Elevated levels of homocysteine (a protein that has been linked to cardiovascular problems)\n- Gastrointestinal symptoms\n- Loss of appetite\n- Problems sleeping\n\nIt is also important to note that SAMe may worsen [symptoms of mania](https:\/\/www.verywellmind.com\/symptoms-of-mania-380311) in people with bipolar disorder.\n\n## Rhodiola Rosea\n![Rhodiola Rosea plant]()\n\n![Rhodiola Rosea plant](https:\/\/www.verywellmind.com\/thmb\/IaggdVRAMZcDmDG2QVcAHwDSQcw=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/rhodiola-rosea-56af37573df78cf772c1a869.JPG)\n\nDaderot \/ Wikimedia Commons \/ Public Domain\n\nAlthough not much English-language research is currently available on [Rhodiola rosea](https:\/\/www.verywellmind.com\/how-is-rhodiola-rosea-used-to-treat-anxiety-3024972), it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress.\n\n### Does Rhodiola Rosea Work For Depression?\nAccording to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use.\n\nOne 2018 study found that Rhodiola rosea extract helped improve symptoms of [stress-related burnout](https:\/\/www.verywellmind.com\/stress-and-burnout-symptoms-and-causes-3144516), including depression.\n\nWhile American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record.\n\n### How Much Rhodiola Rosea Do You Need?\nIn clinical studies, doses range from 100 mg to 400 mg daily. However, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations.\n\n### What to Be Aware Of\nAt low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications:\n\n- Anti-anxiety medication\n- Prescription antidepressants\n- Antibiotics\n- Thyroid medication\n- Medications to treat diabetes\n- Birth control pills\n\n## Vitamins and Minerals\n![Mixed vitamins and supplements]()\n\n![Mixed vitamins and supplements](https:\/\/www.verywellmind.com\/thmb\/fC8h5_wBKMED9SUNAyDpvPirtvk=\/1500x0\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/vitamins-56af375a3df78cf772c1a874.jpg)\n\nBrian Hagiwara Photolibrary \/ Getty Images\n\nA wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12, [chromium](https:\/\/www.verywellmind.com\/chromium-for-depression-1066922), and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression.\n\n### Do Vitamins and Minerals Work For Depression?\nOne meta-analysis suggested that the typical Western diet (which includes larger amounts of red\/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression.\n\nHealthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression.\n\n### How Many Vitamins and Minerals Do You Need?\nIn general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance. Alternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency.\n\n### What to Be Aware Of\nA [healthy diet](https:\/\/www.verywellmind.com\/vitamin-for-depression-1065211) is always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and\/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step.\n\n## Before Taking Over-the-Counter Antidepressants\nThere are a few things to remember before you decide to try over-the-counter antidepressants:\n\n- **They don't replace other treatments.** Don't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy.\n- **They can cause interactions**. Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking.\n- **Their quality can vary**. Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another.\n## Prescription vs. Over-the-Counter Antidepressants\nIt's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants.\n\nSupplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled.\n\nPrescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression.\n\nPrescription Antidepressants\n\n- Examples include Prozac, Zoloft, and Cymbalta\n- FDA-approved (although some may be used off-label)\n- Strong evidence of efficacy\n- Standardized doses\n- Best for moderate to severe depression\n\nOTC Antidepressants\n\n- Examples include St. John's wort, SAMe, and 5-HTP\n- Not FDA-approved for depression\n- Limited to moderate evidence of efficacy\n- Varies by brand\n- Best for mild to moderate depression\n## Seeking Professional Help\nIf you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication.\n\n### Therapy\nYour doctor may recommend that you attend therapy. [Cognitive behavioral therapy](https:\/\/www.verywellmind.com\/what-is-cognitive-behavior-therapy-2795747) (CBT) is a common therapy type used to treat depression.\n\nDuring CBT, a therapist will help you reframe negative thoughts and behaviors and teach you [healthy coping mechanisms](https:\/\/www.verywellmind.com\/forty-healthy-coping-skills-4586742) to help alleviate symptoms of depression.\n\n### Medication\nIn order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a [selective serotonin reuptake inhibitor](https:\/\/www.verywellmind.com\/list-of-ssris-380594) (SSRI). SSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood.\n\nExamples of SSRIs include:\n\n- Trintellix (vortioxetine)\n- [Zoloft](https:\/\/www.verywellmind.com\/zoloft-sertraline-2584329) (sertraline)\n- [Prozac](https:\/\/www.verywellmind.com\/how-is-prozac-used-to-treat-social-anxiety-disorder-3024962) (fluoxetine)\n- [Lexapro](https:\/\/www.verywellmind.com\/anxiety-treatment-and-lexapro-dosage-and-side-effects-3024961) (escitalopram)\n\nOr, a doctor may prescribe a [serotonin-norepinephrine reuptake inhibitor](https:\/\/www.verywellmind.com\/serotonin-and-norepinephrine-reuptake-inhibitors-snris-2584366) (SNRI) such as [Effexor](https:\/\/www.verywellmind.com\/about-effexor-venlafaxine-378783) (venlafaxine).\n\nSSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness. Be sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression.\n\nIf you or a loved one are struggling with depression, contact the [Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline](https:\/\/www.samhsa.gov\/find-help\/national-helpline) at **1-800-662-4357** for information on support and treatment facilities in your area.\n\nFor more mental health resources, see our [National Helpline Database](https:\/\/www.verywellmind.com\/national-helpline-database-4799696).\n\n[Can Natural Antidepressants Help With Depression?](https:\/\/www.verywellmind.com\/natural-antidepressants-for-depression-5270480)\n\nRead more:\n\n- [Conditions A-Z](https:\/\/www.verywellmind.com\/conditions-a-z-4797402)\n- [Depression](https:\/\/www.verywellmind.com\/depression-4157261)\n- [Treatment](https:\/\/www.verywellmind.com\/depression-treatment-4157258)\n\n23 Sources\n\nVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https:\/\/www.verywellmind.com\/our-editorial-process-4778006) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.\n\n1. Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. [Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action](https:\/\/doi.org\/10.1002\/jcp.27781). *J Cell Physiol*. 2019;234(6):8496-8508. doi:10.1002\/jcp.27781\n2. National Center for Complementary and Integrative Health. [St. John's wort and depression: In-depth](https:\/\/www.nccih.nih.gov\/health\/st-johns-wort-and-depression-in-depth).\n3. de Wit L, Jeurissen S, [Chen W. Risk assessment of herbal preparations containing St John's wort](https:\/\/rivm.openrepository.com\/bitstream\/handle\/10029\/624775\/2019-0115.pdf?sequence=1). National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019.\n4. Wani AL, Bhat SA, Ara A. [Omega-3 fatty acids and the treatment of depression: A review of scientific evidence](https:\/\/doi.org\/10.1016\/j.imr.2015.07.003). *Integr Med Res*. 2015;4(3):132-141. doi:10.1016\/j.imr.2015.07.003\n5. Liao Y, Xie B, Zhang H, et al. [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https:\/\/doi.org\/10.1038\/s41398-019-0515-5). *Transl Psychiatry*. 2019;9(1):190. doi:10.1038\/s41398-019-0515-5\n6. Burhani MD, Rasenick MM. [Fish oil and depression: The skinny on fats](https:\/\/doi.org\/10.3233\/JIN-170072). *J Integr Neurosci*. 2017;16(s1):S115-S124. doi:10.3233\/JIN-170072\n7. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for consumers](https:\/\/ods.od.nih.gov\/factsheets\/Omega3FattyAcids-Consumer\/).\n8. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for health professionals](https:\/\/ods.od.nih.gov\/factsheets\/Omega3FattyAcids-HealthProfessional\/).\n9. American Heart Association. [Fish and omega-3 fatty acids](https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/fats\/fish-and-omega-3-fatty-acids).\n10. Maffei ME. [5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology](https:\/\/doi.org\/10.3390%2Fijms22010181). *Int J Mol Sci*. 2020;22(1):181. doi:10.3390\/ijms22010181\n11. Dome P, Tombor L, Lazary J, Gonda X, Rihmer Z. [Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review](https:\/\/doi.org\/10.1016\/j.brainresbull.2018.12.015). *Brain Res Bull*. 2019;146:51-78. doi:10.1016\/j.brainresbull.2018.12.015\n12. Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P. [Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis](https:\/\/doi.org\/10.1093\/nutrit\/nuz039). *Nutr Rev*. 2020;78(1):77-88. doi:10.1093\/nutrit\/nuz039\n13. National Center for Complementary and Integrative Health. [S-adenosyl-l-methionine (SAMe): in depth](https:\/\/www.nccih.nih.gov\/health\/sadenosyllmethionine-same-in-depth).\n14. Jagtap PN, Mhetre OS, Malavdkar PR. [A review article on Rhodiola rosea: An adaptogen having multiple benefits](https:\/\/ijpjournal.com\/wp-content\/uploads\/2020\/04\/2-Vol.-7-Issue-3-Mar-2020-IJP-RE-271.pdf). *Int J Pharmacogn*. 2020;7:62-9.\n15. Amsterdam JD, Panossian AG. [Rhodiola rosea L. as a putative botanical antidepressant](https:\/\/doi.org\/10.1016\/j.phymed.2016.02.009). *Phytomedicine*. 2016;23(7):770-83. doi:10.1016\/j.phymed.2016.02.009\n16. Kasper S, Dienel A. [Multicenter, open-label, exploratory clinical trial with *Rhodiola rosea* extract in patients suffering from burnout symptoms](https:\/\/doi.org\/10.2147\/NDT.S120113). *Neuropsychiatr Dis Treat*. 2017;13:889-898. doi:10.2147\/NDT.S120113\n17. Li Y, Lv MR, Wei YJ, et al. [Dietary patterns and depression risk: A meta-analysis](https:\/\/doi.org\/10.1016\/j.psychres.2017.04.020). *Psychiatry Res*. 2017;253:373-382. doi:10.1016\/j.psychres.2017.04.020\n18. U.S. Department of Health and Human Services and U.S. Department of Agriculture. [2015 – 2020 Dietary Guidelines for Americans. 8th Edition](https:\/\/health.gov\/dietaryguidelines\/2015\/guidelines\/).\n19. U.S. Food and Drug Administration. [Depression medicines](https:\/\/www.fda.gov\/media\/132665\/download#:~:text=Page%205,Feeling%20tired).\n20. Gautam M, Tripathi A, Deshmukh D, Gaur M. [Cognitive behavioral therapy for depression](https:\/\/doi.org\/10.4103\/psychiatry.IndianJPsychiatry_772_19). *Indian J Psychiatry*. 2020;62(Suppl 2):S223-S229. doi:10.4103\/psychiatry.IndianJPsychiatry\\_772\\_19\n21. Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW. [The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder](https:\/\/doi.org\/10.1177\/2045125317737264). *Ther Adv Psychopharmacol*. 2018;8(1):49-58. doi:10.1177\/2045125317737264\n22. Sansone RA, Sansone LA. [Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison](https:\/\/doi.org\/https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4008300\/). *Innov Clin Neurosci*. 2014;11(3-4):37-42.\n23. Santarsieri D, Schwartz TL. [Antidepressant efficacy and side-effect burden: a quick guide for clinicians](https:\/\/doi.org\/10.7573\/dic.212290). *Drugs Context*. 2015;4:212290. doi:10.7573\/dic.212290\n\nBy [Nancy Schimelpfening](https:\/\/www.verywellmind.com\/nancy-schimelpfening-ms-4781235)   \n Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.\n\n[See Our Editorial Process](https:\/\/www.verywellmind.com\/our-editorial-process-4778006)\n\n[Meet Our Review Board](https:\/\/www.verywellmind.com\/review-board-4796494)\n\nShare Feedback\n\nWas this page helpful?\n\nThanks for your feedback\\!\n\nWhat is your feedback?\n\nHelpful\n\nReport an Error\n\nOther\n\nRelated Articles\n\n[![weight gain tight pants]() ![weight gain tight pants](https:\/\/www.verywellmind.com\/thmb\/mbloGm08B85izJDaa14rk3naK4Q=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/weight-gain-56af365e3df78cf772c19cd0.jpg) Does Celexa Cause Weight Gain?](https:\/\/www.verywellmind.com\/citalopram-and-weight-gain-1066818)\n\n[What to Know About Cipralex (Escitalopram)](https:\/\/www.verywellmind.com\/how-cipralex-treats-depression-5093926)\n\n[![Hypericum perforatum]() ![Hypericum perforatum](https:\/\/www.verywellmind.com\/thmb\/lyfN_OyAW4yr3B8eXO22ykdxlZc=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-184362812-583097195f9b58d5b118e2e7.jpg) The Mental Health Benefits of St. John's Wort](https:\/\/www.verywellmind.com\/st-johns-wort-a2-89959)\n\n[![What Are antidepressants?]() ![What Are antidepressants?](https:\/\/www.verywellmind.com\/thmb\/AtHWilyMM1k-lRFKTvml1vSEj7o=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/what-are-the-major-classes-of-antidepressants-1065086_no_text-85790b1ac6384f69a7031ca58a50b809.png) The 5 Types of Antidepressants](https:\/\/www.verywellmind.com\/what-are-the-major-classes-of-antidepressants-1065086)\n\n[Joining a Chat Room to Help With Depression](https:\/\/www.verywellmind.com\/depression-chat-rooms-1067331)\n\n[![doctor's prescription for citalopram]() ![doctor's prescription for citalopram](https:\/\/www.verywellmind.com\/thmb\/ASojRH9B9bYpjUTo80WyK_uaPdc=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-870295882-184f88cf459c48ab88971c1dc4542187.jpg) Celexa Withdrawal: Symptoms, Timeline & Treatment](https:\/\/www.verywellmind.com\/celexa-withdrawal-symptoms-timeline-and-treatment-4771846)\n\n[![Paxil withdrawal]() ![Paxil withdrawal](https:\/\/www.verywellmind.com\/thmb\/4JQvw_Y7cz6JIZeD8U_h5D2v5-Y=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/paxil-withdrawal-symptoms-timeline-and-treatment-4769771_final_no-text-ee8973e5fa504997a3807561a1e50062.png) How Long Does Withdrawal From Paxil Last?](https:\/\/www.verywellmind.com\/paxil-withdrawal-symptoms-timeline-and-treatment-4769771)\n\n[![Dizzy woman by side of road]() ![Dizzy woman by side of road](https:\/\/www.verywellmind.com\/thmb\/5iH_Iq0Fi1iv2edYo3sqLQgcT-g=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-1000229966-d6098f4824a94ae590e196f0de7e40d6.jpg) Symptoms of a Zoloft Overdose](https:\/\/www.verywellmind.com\/zoloft-overdose-1067483)\n\n[![Person holding a handful of antidepressants]() ![Person holding a handful of antidepressants](https:\/\/www.verywellmind.com\/thmb\/k-rNaoFc4tswvRJb-BOA7l6Wqn0=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-951246244-aafb86a3556145b8b2ad04415d62b09b.jpg) Common Antidepressant Medications](https:\/\/www.verywellmind.com\/most-common-antidepressants-1066939)\n\n[![One young man sits, sad, while his friends take a picture]() ![One young man sits, sad, while his friends take a picture](https:\/\/www.verywellmind.com\/thmb\/YFXfuchrI3VvU265PNpf8qcXB3M=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-698202208-5beb4503c9e77c0026fc076f.jpg) Emotional Blunting: Causes, Symptoms & Treatment](https:\/\/www.verywellmind.com\/can-antidepressants-make-you-feel-emotionally-numb-1067348)\n\n[![A sad white man with beard looks at phone]() ![A sad white man with beard looks at phone](https:\/\/www.verywellmind.com\/thmb\/44tDyHo1Nqhm6DWS0kPbWyLg7P4=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/GettyImages-981113982-8bf1a5f4abab4ba5b8161c3e3521a865.jpg) What to Expect from Cymbalta Withdrawal](https:\/\/www.verywellmind.com\/cymbalta-withdrawal-symptoms-timeline-and-treatment-4707711)\n\n[![Prozac overdose]() ![Prozac overdose](https:\/\/www.verywellmind.com\/thmb\/8WR79jYLEGYA6IwKK_aB9JNtSV0=\/400x250\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/prozac-overdose-1067020-color01-e288bf80afcd4cd0bdc548b17b72399d.png) Can You Overdose on Prozac? 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Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment.\n\nⒸ 2026 People Inc. — All rights reserved\n\nVerywell Mind is part of the [People Inc.](https:\/\/www.people.inc\/) publishing family.","attrs_readable_markdown":"By\n\n[Nancy Schimelpfening](https:\/\/www.verywellmind.com\/nancy-schimelpfening-ms-4781235)\n\nNancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.\n\nUpdated on February 17, 2026\n\nMedically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. [Learn more](https:\/\/www.verywellmind.com\/review-board-4796494). by\n\n[Daniel B. Block, MD](https:\/\/www.verywellmind.com\/daniel-block-md-4779186)\n\n![Block](https:\/\/www.verywellmind.com\/thmb\/bqppKq4IVUTVsPMClzJADd5fs14=\/200x200\/filters:no_upscale\\(\\):max_bytes\\(150000\\):strip_icc\\(\\)\/block-8924ca72ff94426d940e8f7e639e3942.jpg)\n\nDaniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania.\n\n### Key Takeaways\n- St. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use.\n- Omega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval.\n- 5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications.\n\nAntidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression.\n\nThese OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management.\n\nSt. John's Wort. esemelwe\/Getty Images\n\n## What Are Over-the-Counter Antidepressants?\nOver-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include:\n\n- St. John's wort\n- Omega-3 fatty acids\n- 5-HTP\n- SAMe\n- Rhodiola rosea\n- Vitamins and minerals like vitamin D and magnesium\n\nOver-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants.\n\n## St. John's Wort\n[St. John's wort](https:\/\/www.verywellmind.com\/st-johns-wort-a2-89959) has a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world.\n\n### Does St. John's Wort Work For Depression?\nThere is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects. The review also noted, however, that the evidence isn't strong enough to make a \"robust conclusion.\"\n\nThe National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment.\n\n### How Much St. John's Wort Do You Need?\nDosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product.\n\n### What to Be Aware Of\nIf you take St. John's wort, it's important to be aware of:\n\n- **Side effects**: Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion.\n- **Drug interactions**: Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person.\n- **Serotonin syndrome**: If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other [medication that increases serotonin](https:\/\/www.verywellmind.com\/medications-and-serotonin-syndrome-2584342), there is a risk for [serotonin syndrome](https:\/\/www.verywellmind.com\/what-is-serotonin-syndrome-379651), which can be fatal.\n- **Sun sensitivity**: St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen.\n\n## Omega-3 Fatty Acids\nSharaff \/ Getty Images\n\nOmega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health.\n\nThere are three types of omega-3s:\n\n- Alpha-linolenic acid (ALA)\n- Eicosapentaenoic acid (EPA)\n- Docosahexaenoic acid (DHA)\n### Do Omega-3 Fatty Acids Work For Depression?\nMore research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression.\n\n- EPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits.\n- A 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression.\n\nWhile omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes.\n\n### How Much Omega-3 Do You Need?\nMost Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA. You can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk.\n\nNo particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding.\n\n### How to Get More Omega-3s\nSince our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements.\n\nFoods that are high in omega-3s include:\n\n- Fish (especially salmon, mackerel, tuna, sardines, and herring)\n- Nuts and seeds (including walnuts, chia seeds, and flax seeds)\n- Plant oils (including canola oil, soybean oil, and flaxseed oil)\n### What to Be Aware Of\nIf you decide to try taking supplemental omega-3s, there are a few things to be aware of:\n\n- **Stomach upset**: While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses.\n- **Increased blood thinning**: Omega-3 supplements may increase the effects of blood-thinning medications.\n\nFor those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health, which could be taken as a good minimum consumption level.\n\n## 5-HTP\nJynto \/ Wikimedia Commons \/ CC0\n\n[5-HTP](https:\/\/www.verywellmind.com\/5-htp-5-hydroxytryptophan-88320), or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase [serotonin](https:\/\/www.verywellmind.com\/what-is-serotonin-425327), a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression.\n\n5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of *Griffonia simplicifolia,* a plant native to Central and Western Africa*.*\n\nThe body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase. Taking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin.\n\n### Does 5-HTP Work For Depression?\nWhile better-quality studies are needed to firmly establish its [effectiveness as an antidepressant](https:\/\/www.verywellmind.com\/5-htp-for-depression-1066521), a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases. However, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program.\n\n### How Much 5-HTP Do You Need?\nIn clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day. However, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs.\n\n### What to Be Aware Of\n5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include:\n\n- Diarrhea\n- Dizziness\n- Drowsiness\n- Feelings of anxiety\n- Muscular tenderness\n- Nausea\n- Sexual dysfunction\n\n5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM).\n\n5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin.\n\n## SAMe\nNEUROtiker \/ Wikimedia Commons \/ Public Domain\n\n[SAMe](https:\/\/www.verywellmind.com\/how-sam-e-can-benefit-mental-health-6745925) (S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement.\n\nSAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression.\n\n### Does SAMe Work For Depression?\nStudies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants.\n\n### How Much SAMe Do You Need?\nFollow the package directions or consult with your physician for an appropriate dose for you.\n\n### What to Be Aware Of\nPotential side effects include:\n\n- Dizziness\n- Elevated levels of homocysteine (a protein that has been linked to cardiovascular problems)\n- Gastrointestinal symptoms\n- Loss of appetite\n- Problems sleeping\n\nIt is also important to note that SAMe may worsen [symptoms of mania](https:\/\/www.verywellmind.com\/symptoms-of-mania-380311) in people with bipolar disorder.\n\n## Rhodiola Rosea\nDaderot \/ Wikimedia Commons \/ Public Domain\n\nAlthough not much English-language research is currently available on [Rhodiola rosea](https:\/\/www.verywellmind.com\/how-is-rhodiola-rosea-used-to-treat-anxiety-3024972), it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress.\n\n### Does Rhodiola Rosea Work For Depression?\nAccording to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use.\n\nOne 2018 study found that Rhodiola rosea extract helped improve symptoms of [stress-related burnout](https:\/\/www.verywellmind.com\/stress-and-burnout-symptoms-and-causes-3144516), including depression.\n\nWhile American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record.\n\n### How Much Rhodiola Rosea Do You Need?\nIn clinical studies, doses range from 100 mg to 400 mg daily. However, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations.\n\n### What to Be Aware Of\nAt low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications:\n\n- Anti-anxiety medication\n- Prescription antidepressants\n- Antibiotics\n- Thyroid medication\n- Medications to treat diabetes\n- Birth control pills\n\n## Vitamins and Minerals\nBrian Hagiwara Photolibrary \/ Getty Images\n\nA wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12, [chromium](https:\/\/www.verywellmind.com\/chromium-for-depression-1066922), and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression.\n\n### Do Vitamins and Minerals Work For Depression?\nOne meta-analysis suggested that the typical Western diet (which includes larger amounts of red\/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression.\n\nHealthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression.\n\n### How Many Vitamins and Minerals Do You Need?\nIn general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance. Alternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency.\n\n### What to Be Aware Of\nA [healthy diet](https:\/\/www.verywellmind.com\/vitamin-for-depression-1065211) is always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and\/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step.\n\n## Before Taking Over-the-Counter Antidepressants\nThere are a few things to remember before you decide to try over-the-counter antidepressants:\n\n- **They don't replace other treatments.** Don't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy.\n- **They can cause interactions**. Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking.\n- **Their quality can vary**. Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another.\n## Prescription vs. Over-the-Counter Antidepressants\nIt's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants.\n\nSupplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled.\n\nPrescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression.\n\nPrescription Antidepressants\n\n- Examples include Prozac, Zoloft, and Cymbalta\n- FDA-approved (although some may be used off-label)\n- Strong evidence of efficacy\n- Standardized doses\n- Best for moderate to severe depression\n\nOTC Antidepressants\n\n- Examples include St. John's wort, SAMe, and 5-HTP\n- Not FDA-approved for depression\n- Limited to moderate evidence of efficacy\n- Varies by brand\n- Best for mild to moderate depression\n## Seeking Professional Help\nIf you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication.\n\n### Therapy\nYour doctor may recommend that you attend therapy. [Cognitive behavioral therapy](https:\/\/www.verywellmind.com\/what-is-cognitive-behavior-therapy-2795747) (CBT) is a common therapy type used to treat depression.\n\nDuring CBT, a therapist will help you reframe negative thoughts and behaviors and teach you [healthy coping mechanisms](https:\/\/www.verywellmind.com\/forty-healthy-coping-skills-4586742) to help alleviate symptoms of depression.\n\n### Medication\nIn order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a [selective serotonin reuptake inhibitor](https:\/\/www.verywellmind.com\/list-of-ssris-380594) (SSRI). SSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood.\n\nExamples of SSRIs include:\n\n- Trintellix (vortioxetine)\n- [Zoloft](https:\/\/www.verywellmind.com\/zoloft-sertraline-2584329) (sertraline)\n- [Prozac](https:\/\/www.verywellmind.com\/how-is-prozac-used-to-treat-social-anxiety-disorder-3024962) (fluoxetine)\n- [Lexapro](https:\/\/www.verywellmind.com\/anxiety-treatment-and-lexapro-dosage-and-side-effects-3024961) (escitalopram)\n\nOr, a doctor may prescribe a [serotonin-norepinephrine reuptake inhibitor](https:\/\/www.verywellmind.com\/serotonin-and-norepinephrine-reuptake-inhibitors-snris-2584366) (SNRI) such as [Effexor](https:\/\/www.verywellmind.com\/about-effexor-venlafaxine-378783) (venlafaxine).\n\nSSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness. Be sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression.\n\n23 Sources\n\nVerywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https:\/\/www.verywellmind.com\/our-editorial-process-4778006) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.\n\n1. Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. [Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action](https:\/\/doi.org\/10.1002\/jcp.27781). *J Cell Physiol*. 2019;234(6):8496-8508. doi:10.1002\/jcp.27781\n2. National Center for Complementary and Integrative Health. [St. John's wort and depression: In-depth](https:\/\/www.nccih.nih.gov\/health\/st-johns-wort-and-depression-in-depth).\n3. de Wit L, Jeurissen S, [Chen W. Risk assessment of herbal preparations containing St John's wort](https:\/\/rivm.openrepository.com\/bitstream\/handle\/10029\/624775\/2019-0115.pdf?sequence=1). National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019.\n4. Wani AL, Bhat SA, Ara A. [Omega-3 fatty acids and the treatment of depression: A review of scientific evidence](https:\/\/doi.org\/10.1016\/j.imr.2015.07.003). *Integr Med Res*. 2015;4(3):132-141. doi:10.1016\/j.imr.2015.07.003\n5. Liao Y, Xie B, Zhang H, et al. [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https:\/\/doi.org\/10.1038\/s41398-019-0515-5). *Transl Psychiatry*. 2019;9(1):190. doi:10.1038\/s41398-019-0515-5\n6. Burhani MD, Rasenick MM. [Fish oil and depression: The skinny on fats](https:\/\/doi.org\/10.3233\/JIN-170072). *J Integr Neurosci*. 2017;16(s1):S115-S124. doi:10.3233\/JIN-170072\n7. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for consumers](https:\/\/ods.od.nih.gov\/factsheets\/Omega3FattyAcids-Consumer\/).\n8. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for health professionals](https:\/\/ods.od.nih.gov\/factsheets\/Omega3FattyAcids-HealthProfessional\/).\n9. American Heart Association. [Fish and omega-3 fatty acids](https:\/\/www.heart.org\/en\/healthy-living\/healthy-eating\/eat-smart\/fats\/fish-and-omega-3-fatty-acids).\n10. Maffei ME. [5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology](https:\/\/doi.org\/10.3390%2Fijms22010181). *Int J Mol Sci*. 2020;22(1):181. doi:10.3390\/ijms22010181\n11. Dome P, Tombor L, Lazary J, Gonda X, Rihmer Z. [Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review](https:\/\/doi.org\/10.1016\/j.brainresbull.2018.12.015). *Brain Res Bull*. 2019;146:51-78. doi:10.1016\/j.brainresbull.2018.12.015\n12. Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P. [Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis](https:\/\/doi.org\/10.1093\/nutrit\/nuz039). *Nutr Rev*. 2020;78(1):77-88. doi:10.1093\/nutrit\/nuz039\n13. National Center for Complementary and Integrative Health. [S-adenosyl-l-methionine (SAMe): in depth](https:\/\/www.nccih.nih.gov\/health\/sadenosyllmethionine-same-in-depth).\n14. Jagtap PN, Mhetre OS, Malavdkar PR. [A review article on Rhodiola rosea: An adaptogen having multiple benefits](https:\/\/ijpjournal.com\/wp-content\/uploads\/2020\/04\/2-Vol.-7-Issue-3-Mar-2020-IJP-RE-271.pdf). *Int J Pharmacogn*. 2020;7:62-9.\n15. Amsterdam JD, Panossian AG. [Rhodiola rosea L. as a putative botanical antidepressant](https:\/\/doi.org\/10.1016\/j.phymed.2016.02.009). *Phytomedicine*. 2016;23(7):770-83. doi:10.1016\/j.phymed.2016.02.009\n16. Kasper S, Dienel A. [Multicenter, open-label, exploratory clinical trial with *Rhodiola rosea* extract in patients suffering from burnout symptoms](https:\/\/doi.org\/10.2147\/NDT.S120113). *Neuropsychiatr Dis Treat*. 2017;13:889-898. doi:10.2147\/NDT.S120113\n17. Li Y, Lv MR, Wei YJ, et al. [Dietary patterns and depression risk: A meta-analysis](https:\/\/doi.org\/10.1016\/j.psychres.2017.04.020). *Psychiatry Res*. 2017;253:373-382. doi:10.1016\/j.psychres.2017.04.020\n18. U.S. Department of Health and Human Services and U.S. Department of Agriculture. [2015 – 2020 Dietary Guidelines for Americans. 8th Edition](https:\/\/health.gov\/dietaryguidelines\/2015\/guidelines\/).\n19. U.S. Food and Drug Administration. [Depression medicines](https:\/\/www.fda.gov\/media\/132665\/download#:~:text=Page%205,Feeling%20tired).\n20. Gautam M, Tripathi A, Deshmukh D, Gaur M. [Cognitive behavioral therapy for depression](https:\/\/doi.org\/10.4103\/psychiatry.IndianJPsychiatry_772_19). *Indian J Psychiatry*. 2020;62(Suppl 2):S223-S229. doi:10.4103\/psychiatry.IndianJPsychiatry\\_772\\_19\n21. Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW. [The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder](https:\/\/doi.org\/10.1177\/2045125317737264). *Ther Adv Psychopharmacol*. 2018;8(1):49-58. doi:10.1177\/2045125317737264\n22. Sansone RA, Sansone LA. [Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison](https:\/\/doi.org\/https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4008300\/). *Innov Clin Neurosci*. 2014;11(3-4):37-42.\n23. Santarsieri D, Schwartz TL. [Antidepressant efficacy and side-effect burden: a quick guide for clinicians](https:\/\/doi.org\/10.7573\/dic.212290). *Drugs Context*. 2015;4:212290. doi:10.7573\/dic.212290\n\nBy [Nancy Schimelpfening](https:\/\/www.verywellmind.com\/nancy-schimelpfening-ms-4781235)   \n Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be.\n\nWas this page helpful?\n\nThanks for your feedback\\!\n\nWhat is your feedback?","meta_canonical":null,"ml_categories_json":"{\"\/Health\":997,\"\/Health\/Mental_Health\":936,\"\/Health\/Mental_Health\/Depression\":935}","ml_types_json":"{\"\/Article\":998,\"\/Article\/Tutorial_or_Guide\":769}","ml_intent_types_json":"{\"Informational\":999}","meta_language":"en","attrs_author":null,"attrs_publish_time":0,"attrs_original_publish_time":1520088728,"attrs_is_republished":0,"attrs_nr_words":"3728","attrs_boilerpipe_nr_words":"3172","body_ext_links_number":64,"body_int_links_number":89,"meta_nofollow":0,"meta_noarchive":1,"props_was_rendered":0,"src_redirect":"","download_time_msec":216,"download_ttfb_msec":153,"download_size":65213}

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By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Updated on February 17, 2026 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more . by Daniel B. Block, MD Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Key Takeaways St. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use. Omega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval. 5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications. Antidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression. These OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management. St. John's Wort. esemelwe/Getty Images What Are Over-the-Counter Antidepressants? Over-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include: St. John's wort Omega-3 fatty acids 5-HTP SAMe Rhodiola rosea Vitamins and minerals like vitamin D and magnesium Over-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants. St. John's Wort St. John's wort has a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world. Does St. John's Wort Work For Depression? There is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects. The review also noted, however, that the evidence isn't strong enough to make a "robust conclusion." The National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment. How Much St. John's Wort Do You Need? Dosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product. What to Be Aware Of If you take St. John's wort, it's important to be aware of: Side effects : Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion. Drug interactions : Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person. Serotonin syndrome : If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other medication that increases serotonin , there is a risk for serotonin syndrome , which can be fatal. Sun sensitivity : St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen. Omega-3 Fatty Acids Sharaff / Getty Images Omega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health. There are three types of omega-3s: Alpha-linolenic acid (ALA) Eicosapentaenoic acid (EPA) Docosahexaenoic acid (DHA) Do Omega-3 Fatty Acids Work For Depression? More research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression. EPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits. A 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression. While omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes. How Much Omega-3 Do You Need? Most Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA. You can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk. No particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding. How to Get More Omega-3s Since our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements. Foods that are high in omega-3s include: Fish (especially salmon, mackerel, tuna, sardines, and herring) Nuts and seeds (including walnuts, chia seeds, and flax seeds) Plant oils (including canola oil, soybean oil, and flaxseed oil) What to Be Aware Of If you decide to try taking supplemental omega-3s, there are a few things to be aware of: Stomach upset : While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses. Increased blood thinning : Omega-3 supplements may increase the effects of blood-thinning medications. For those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health, which could be taken as a good minimum consumption level. 5-HTP Jynto / Wikimedia Commons / CC0 5-HTP , or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase serotonin , a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression. 5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of Griffonia simplicifolia, a plant native to Central and Western Africa . The body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase. Taking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin. Does 5-HTP Work For Depression? While better-quality studies are needed to firmly establish its effectiveness as an antidepressant , a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases. However, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program. How Much 5-HTP Do You Need? In clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day. However, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs. What to Be Aware Of 5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include: Diarrhea Dizziness Drowsiness Feelings of anxiety Muscular tenderness Nausea Sexual dysfunction 5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM). 5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin. SAMe NEUROtiker / Wikimedia Commons / Public Domain SAMe (S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement. SAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression. Does SAMe Work For Depression? Studies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants. How Much SAMe Do You Need? Follow the package directions or consult with your physician for an appropriate dose for you. What to Be Aware Of Potential side effects include: Dizziness Elevated levels of homocysteine (a protein that has been linked to cardiovascular problems) Gastrointestinal symptoms Loss of appetite Problems sleeping It is also important to note that SAMe may worsen symptoms of mania in people with bipolar disorder. Rhodiola Rosea Daderot / Wikimedia Commons / Public Domain Although not much English-language research is currently available on Rhodiola rosea , it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress. Does Rhodiola Rosea Work For Depression? According to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use. One 2018 study found that Rhodiola rosea extract helped improve symptoms of stress-related burnout , including depression. While American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record. How Much Rhodiola Rosea Do You Need? In clinical studies, doses range from 100 mg to 400 mg daily. However, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations. What to Be Aware Of At low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications: Anti-anxiety medication Prescription antidepressants Antibiotics Thyroid medication Medications to treat diabetes Birth control pills Vitamins and Minerals Brian Hagiwara Photolibrary / Getty Images A wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12, chromium , and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression. Do Vitamins and Minerals Work For Depression? One meta-analysis suggested that the typical Western diet (which includes larger amounts of red/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression. Healthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression. How Many Vitamins and Minerals Do You Need? In general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance. Alternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency. What to Be Aware Of A healthy diet is always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step. Before Taking Over-the-Counter Antidepressants There are a few things to remember before you decide to try over-the-counter antidepressants: They don't replace other treatments. Don't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy. They can cause interactions . Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking. Their quality can vary . Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another. Prescription vs. Over-the-Counter Antidepressants It's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants. Supplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled. Prescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression. Prescription Antidepressants Examples include Prozac, Zoloft, and Cymbalta FDA-approved (although some may be used off-label) Strong evidence of efficacy Standardized doses Best for moderate to severe depression OTC Antidepressants Examples include St. John's wort, SAMe, and 5-HTP Not FDA-approved for depression Limited to moderate evidence of efficacy Varies by brand Best for mild to moderate depression Seeking Professional Help If you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication. Therapy Your doctor may recommend that you attend therapy. Cognitive behavioral therapy (CBT) is a common therapy type used to treat depression. During CBT, a therapist will help you reframe negative thoughts and behaviors and teach you healthy coping mechanisms to help alleviate symptoms of depression. Medication In order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a selective serotonin reuptake inhibitor (SSRI). SSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood. Examples of SSRIs include: Trintellix (vortioxetine) Zoloft (sertraline) Prozac (fluoxetine) Lexapro (escitalopram) Or, a doctor may prescribe a serotonin-norepinephrine reuptake inhibitor (SNRI) such as Effexor (venlafaxine). SSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness. Be sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression. 23 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action . J Cell Physiol . 2019;234(6):8496-8508. doi:10.1002/jcp.27781 National Center for Complementary and Integrative Health. St. John's wort and depression: In-depth . de Wit L, Jeurissen S, Chen W. Risk assessment of herbal preparations containing St John's wort . National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019. Wani AL, Bhat SA, Ara A. Omega-3 fatty acids and the treatment of depression: A review of scientific evidence . Integr Med Res . 2015;4(3):132-141. doi:10.1016/j.imr.2015.07.003 Liao Y, Xie B, Zhang H, et al. Efficacy of omega-3 PUFAs in depression: A meta-analysis . Transl Psychiatry . 2019;9(1):190. doi:10.1038/s41398-019-0515-5 Burhani MD, Rasenick MM. Fish oil and depression: The skinny on fats . J Integr Neurosci . 2017;16(s1):S115-S124. doi:10.3233/JIN-170072 National Institutes of Health Office of Dietary Supplements. Omega-3 fatty acids: Fact sheet for consumers . National Institutes of Health Office of Dietary Supplements. Omega-3 fatty acids: Fact sheet for health professionals . American Heart Association. Fish and omega-3 fatty acids . Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology . Int J Mol Sci . 2020;22(1):181. doi:10.3390/ijms22010181 Dome P, Tombor L, Lazary J, Gonda X, Rihmer Z. Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review . Brain Res Bull . 2019;146:51-78. doi:10.1016/j.brainresbull.2018.12.015 Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P. Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis . Nutr Rev . 2020;78(1):77-88. doi:10.1093/nutrit/nuz039 National Center for Complementary and Integrative Health. S-adenosyl-l-methionine (SAMe): in depth . Jagtap PN, Mhetre OS, Malavdkar PR. A review article on Rhodiola rosea: An adaptogen having multiple benefits . Int J Pharmacogn . 2020;7:62-9. Amsterdam JD, Panossian AG. Rhodiola rosea L. as a putative botanical antidepressant . Phytomedicine . 2016;23(7):770-83. doi:10.1016/j.phymed.2016.02.009 Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms . Neuropsychiatr Dis Treat . 2017;13:889-898. doi:10.2147/NDT.S120113 Li Y, Lv MR, Wei YJ, et al. Dietary patterns and depression risk: A meta-analysis . Psychiatry Res . 2017;253:373-382. doi:10.1016/j.psychres.2017.04.020 U.S. Department of Health and Human Services and U.S. Department of Agriculture. 2015 – 2020 Dietary Guidelines for Americans. 8th Edition . U.S. Food and Drug Administration. Depression medicines . Gautam M, Tripathi A, Deshmukh D, Gaur M. Cognitive behavioral therapy for depression . Indian J Psychiatry . 2020;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry_772_19 Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW. The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder . Ther Adv Psychopharmacol . 2018;8(1):49-58. doi:10.1177/2045125317737264 Sansone RA, Sansone LA. Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison . Innov Clin Neurosci . 2014;11(3-4):37-42. Santarsieri D, Schwartz TL. Antidepressant efficacy and side-effect burden: a quick guide for clinicians . Drugs Context . 2015;4:212290. doi:10.7573/dic.212290 By Nancy Schimelpfening Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Was this page helpful? Thanks for your feedback! What is your feedback?

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Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Ⓒ 2026 People Inc. — All rights reserved # Over-the-Counter Antidepressants By [Nancy Schimelpfening](https://www.verywellmind.com/nancy-schimelpfening-ms-4781235) [Nancy Schimelpfening](https://www.verywellmind.com/nancy-schimelpfening-ms-4781235) Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Learn about our [editorial process](https://www.verywellmind.com/our-editorial-process-4778006) Updated on February 17, 2026 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. [Learn more](https://www.verywellmind.com/review-board-4796494). by [Daniel B. Block, MD](https://www.verywellmind.com/daniel-block-md-4779186) ![Block]() ![Block](https://www.verywellmind.com/thmb/bqppKq4IVUTVsPMClzJADd5fs14=/200x200/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/block-8924ca72ff94426d940e8f7e639e3942.jpg) Medically reviewed by [Daniel B. Block, MD](https://www.verywellmind.com/daniel-block-md-4779186) Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. Learn about our [Medical Review Board](https://www.verywellmind.com/review-board-4796494) Table of Contents View All Table of Contents - [What Are OTC Antidepressants?](https://www.verywellmind.com/over-the-counter-antidepressants-1066678#toc-what-are-over-the-counter-antidepressants) - [Things to Know](https://www.verywellmind.com/over-the-counter-antidepressants-1066678#toc-before-taking-over-the-counter-antidepressants) - [Prescription vs. OTC](https://www.verywellmind.com/over-the-counter-antidepressants-1066678#toc-prescription-vs-over-the-counter-antidepressants) - [Seeking Professional Help](https://www.verywellmind.com/over-the-counter-antidepressants-1066678#toc-seeking-professional-help) Close ### Key Takeaways - St. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use. - Omega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval. - 5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications. Antidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression. These OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management. ![Closeup of blooming St Johns wort flowers]() ![Closeup of blooming St Johns wort flowers](https://www.verywellmind.com/thmb/p_B45Mc-WZIQKt_elJyI9uyT2Fw=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/st-johns-wort-56af35893df78cf772c1933f.jpg) St. John's Wort. esemelwe/Getty Images ## What Are Over-the-Counter Antidepressants? Over-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include: - St. John's wort - Omega-3 fatty acids - 5-HTP - SAMe - Rhodiola rosea - Vitamins and minerals like vitamin D and magnesium Over-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants. ## St. John's Wort [St. John's wort](https://www.verywellmind.com/st-johns-wort-a2-89959) has a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world. ### Does St. John's Wort Work For Depression? There is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects. The review also noted, however, that the evidence isn't strong enough to make a "robust conclusion." The National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment. ### How Much St. John's Wort Do You Need? Dosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product. ### What to Be Aware Of If you take St. John's wort, it's important to be aware of: - **Side effects**: Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion. - **Drug interactions**: Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person. - **Serotonin syndrome**: If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other [medication that increases serotonin](https://www.verywellmind.com/medications-and-serotonin-syndrome-2584342), there is a risk for [serotonin syndrome](https://www.verywellmind.com/what-is-serotonin-syndrome-379651), which can be fatal. - **Sun sensitivity**: St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen. ## Omega-3 Fatty Acids ![Oil capsules spilling out of a bottle]() ![Oil capsules spilling out of a bottle](https://www.verywellmind.com/thmb/dJObspOd5H80ZjlyuxK0Vkv3qhk=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/fish-oil-capsules-56af37513df78cf772c1a840.jpg) Sharaff / Getty Images Omega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health. There are three types of omega-3s: - Alpha-linolenic acid (ALA) - Eicosapentaenoic acid (EPA) - Docosahexaenoic acid (DHA) ### Do Omega-3 Fatty Acids Work For Depression? More research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression. - EPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits. - A 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression. While omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes. ### How Much Omega-3 Do You Need? Most Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA. You can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk. No particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding. ### How to Get More Omega-3s Since our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements. Foods that are high in omega-3s include: - Fish (especially salmon, mackerel, tuna, sardines, and herring) - Nuts and seeds (including walnuts, chia seeds, and flax seeds) - Plant oils (including canola oil, soybean oil, and flaxseed oil) ### What to Be Aware Of If you decide to try taking supplemental omega-3s, there are a few things to be aware of: - **Stomach upset**: While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses. - **Increased blood thinning**: Omega-3 supplements may increase the effects of blood-thinning medications. For those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health, which could be taken as a good minimum consumption level. ## 5-HTP ![Chemical model]() ![Chemical model](https://www.verywellmind.com/thmb/amUSi9yxYB25WK0oNJjbuZttSeI=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/5-htp-56af37535f9b58b7d0160c21.png) Jynto / Wikimedia Commons / CC0 [5-HTP](https://www.verywellmind.com/5-htp-5-hydroxytryptophan-88320), or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase [serotonin](https://www.verywellmind.com/what-is-serotonin-425327), a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression. 5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of *Griffonia simplicifolia,* a plant native to Central and Western Africa*.* The body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase. Taking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin. ### Does 5-HTP Work For Depression? While better-quality studies are needed to firmly establish its [effectiveness as an antidepressant](https://www.verywellmind.com/5-htp-for-depression-1066521), a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases. However, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program. ### How Much 5-HTP Do You Need? In clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day. However, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs. ### What to Be Aware Of 5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include: - Diarrhea - Dizziness - Drowsiness - Feelings of anxiety - Muscular tenderness - Nausea - Sexual dysfunction 5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM). 5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin. ## SAMe ![Chemical formula]() ![Chemical formula](https://www.verywellmind.com/thmb/mdWTy2J7UPtNb5lw3hNZB6_dnMk=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/same-56af37555f9b58b7d0160c2e.png) NEUROtiker / Wikimedia Commons / Public Domain [SAMe](https://www.verywellmind.com/how-sam-e-can-benefit-mental-health-6745925) (S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement. SAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression. ### Does SAMe Work For Depression? Studies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants. ### How Much SAMe Do You Need? Follow the package directions or consult with your physician for an appropriate dose for you. ### What to Be Aware Of Potential side effects include: - Dizziness - Elevated levels of homocysteine (a protein that has been linked to cardiovascular problems) - Gastrointestinal symptoms - Loss of appetite - Problems sleeping It is also important to note that SAMe may worsen [symptoms of mania](https://www.verywellmind.com/symptoms-of-mania-380311) in people with bipolar disorder. ## Rhodiola Rosea ![Rhodiola Rosea plant]() ![Rhodiola Rosea plant](https://www.verywellmind.com/thmb/IaggdVRAMZcDmDG2QVcAHwDSQcw=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/rhodiola-rosea-56af37573df78cf772c1a869.JPG) Daderot / Wikimedia Commons / Public Domain Although not much English-language research is currently available on [Rhodiola rosea](https://www.verywellmind.com/how-is-rhodiola-rosea-used-to-treat-anxiety-3024972), it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress. ### Does Rhodiola Rosea Work For Depression? According to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use. One 2018 study found that Rhodiola rosea extract helped improve symptoms of [stress-related burnout](https://www.verywellmind.com/stress-and-burnout-symptoms-and-causes-3144516), including depression. While American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record. ### How Much Rhodiola Rosea Do You Need? In clinical studies, doses range from 100 mg to 400 mg daily. However, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations. ### What to Be Aware Of At low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications: - Anti-anxiety medication - Prescription antidepressants - Antibiotics - Thyroid medication - Medications to treat diabetes - Birth control pills ## Vitamins and Minerals ![Mixed vitamins and supplements]() ![Mixed vitamins and supplements](https://www.verywellmind.com/thmb/fC8h5_wBKMED9SUNAyDpvPirtvk=/1500x0/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/vitamins-56af375a3df78cf772c1a874.jpg) Brian Hagiwara Photolibrary / Getty Images A wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12, [chromium](https://www.verywellmind.com/chromium-for-depression-1066922), and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression. ### Do Vitamins and Minerals Work For Depression? One meta-analysis suggested that the typical Western diet (which includes larger amounts of red/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression. Healthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression. ### How Many Vitamins and Minerals Do You Need? In general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance. Alternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency. ### What to Be Aware Of A [healthy diet](https://www.verywellmind.com/vitamin-for-depression-1065211) is always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step. ## Before Taking Over-the-Counter Antidepressants There are a few things to remember before you decide to try over-the-counter antidepressants: - **They don't replace other treatments.** Don't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy. - **They can cause interactions**. Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking. - **Their quality can vary**. Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another. ## Prescription vs. Over-the-Counter Antidepressants It's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants. Supplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled. Prescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression. Prescription Antidepressants - Examples include Prozac, Zoloft, and Cymbalta - FDA-approved (although some may be used off-label) - Strong evidence of efficacy - Standardized doses - Best for moderate to severe depression OTC Antidepressants - Examples include St. John's wort, SAMe, and 5-HTP - Not FDA-approved for depression - Limited to moderate evidence of efficacy - Varies by brand - Best for mild to moderate depression ## Seeking Professional Help If you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication. ### Therapy Your doctor may recommend that you attend therapy. [Cognitive behavioral therapy](https://www.verywellmind.com/what-is-cognitive-behavior-therapy-2795747) (CBT) is a common therapy type used to treat depression. During CBT, a therapist will help you reframe negative thoughts and behaviors and teach you [healthy coping mechanisms](https://www.verywellmind.com/forty-healthy-coping-skills-4586742) to help alleviate symptoms of depression. ### Medication In order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a [selective serotonin reuptake inhibitor](https://www.verywellmind.com/list-of-ssris-380594) (SSRI). SSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood. Examples of SSRIs include: - Trintellix (vortioxetine) - [Zoloft](https://www.verywellmind.com/zoloft-sertraline-2584329) (sertraline) - [Prozac](https://www.verywellmind.com/how-is-prozac-used-to-treat-social-anxiety-disorder-3024962) (fluoxetine) - [Lexapro](https://www.verywellmind.com/anxiety-treatment-and-lexapro-dosage-and-side-effects-3024961) (escitalopram) Or, a doctor may prescribe a [serotonin-norepinephrine reuptake inhibitor](https://www.verywellmind.com/serotonin-and-norepinephrine-reuptake-inhibitors-snris-2584366) (SNRI) such as [Effexor](https://www.verywellmind.com/about-effexor-venlafaxine-378783) (venlafaxine). SSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness. Be sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression. If you or a loved one are struggling with depression, contact the [Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline](https://www.samhsa.gov/find-help/national-helpline) at **1-800-662-4357** for information on support and treatment facilities in your area. For more mental health resources, see our [National Helpline Database](https://www.verywellmind.com/national-helpline-database-4799696). [Can Natural Antidepressants Help With Depression?](https://www.verywellmind.com/natural-antidepressants-for-depression-5270480) Read more: - [Conditions A-Z](https://www.verywellmind.com/conditions-a-z-4797402) - [Depression](https://www.verywellmind.com/depression-4157261) - [Treatment](https://www.verywellmind.com/depression-treatment-4157258) 23 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https://www.verywellmind.com/our-editorial-process-4778006) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. 1. Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. [Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action](https://doi.org/10.1002/jcp.27781). *J Cell Physiol*. 2019;234(6):8496-8508. doi:10.1002/jcp.27781 2. National Center for Complementary and Integrative Health. [St. John's wort and depression: In-depth](https://www.nccih.nih.gov/health/st-johns-wort-and-depression-in-depth). 3. de Wit L, Jeurissen S, [Chen W. Risk assessment of herbal preparations containing St John's wort](https://rivm.openrepository.com/bitstream/handle/10029/624775/2019-0115.pdf?sequence=1). National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019. 4. Wani AL, Bhat SA, Ara A. [Omega-3 fatty acids and the treatment of depression: A review of scientific evidence](https://doi.org/10.1016/j.imr.2015.07.003). *Integr Med Res*. 2015;4(3):132-141. doi:10.1016/j.imr.2015.07.003 5. Liao Y, Xie B, Zhang H, et al. [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https://doi.org/10.1038/s41398-019-0515-5). *Transl Psychiatry*. 2019;9(1):190. doi:10.1038/s41398-019-0515-5 6. Burhani MD, Rasenick MM. [Fish oil and depression: The skinny on fats](https://doi.org/10.3233/JIN-170072). *J Integr Neurosci*. 2017;16(s1):S115-S124. doi:10.3233/JIN-170072 7. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for consumers](https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/). 8. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for health professionals](https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/). 9. American Heart Association. [Fish and omega-3 fatty acids](https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids). 10. Maffei ME. [5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology](https://doi.org/10.3390%2Fijms22010181). *Int J Mol Sci*. 2020;22(1):181. doi:10.3390/ijms22010181 11. Dome P, Tombor L, Lazary J, Gonda X, Rihmer Z. [Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review](https://doi.org/10.1016/j.brainresbull.2018.12.015). *Brain Res Bull*. 2019;146:51-78. doi:10.1016/j.brainresbull.2018.12.015 12. Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P. [Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis](https://doi.org/10.1093/nutrit/nuz039). *Nutr Rev*. 2020;78(1):77-88. doi:10.1093/nutrit/nuz039 13. National Center for Complementary and Integrative Health. [S-adenosyl-l-methionine (SAMe): in depth](https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth). 14. Jagtap PN, Mhetre OS, Malavdkar PR. [A review article on Rhodiola rosea: An adaptogen having multiple benefits](https://ijpjournal.com/wp-content/uploads/2020/04/2-Vol.-7-Issue-3-Mar-2020-IJP-RE-271.pdf). *Int J Pharmacogn*. 2020;7:62-9. 15. Amsterdam JD, Panossian AG. [Rhodiola rosea L. as a putative botanical antidepressant](https://doi.org/10.1016/j.phymed.2016.02.009). *Phytomedicine*. 2016;23(7):770-83. doi:10.1016/j.phymed.2016.02.009 16. Kasper S, Dienel A. [Multicenter, open-label, exploratory clinical trial with *Rhodiola rosea* extract in patients suffering from burnout symptoms](https://doi.org/10.2147/NDT.S120113). *Neuropsychiatr Dis Treat*. 2017;13:889-898. doi:10.2147/NDT.S120113 17. Li Y, Lv MR, Wei YJ, et al. [Dietary patterns and depression risk: A meta-analysis](https://doi.org/10.1016/j.psychres.2017.04.020). *Psychiatry Res*. 2017;253:373-382. doi:10.1016/j.psychres.2017.04.020 18. U.S. Department of Health and Human Services and U.S. Department of Agriculture. [2015 – 2020 Dietary Guidelines for Americans. 8th Edition](https://health.gov/dietaryguidelines/2015/guidelines/). 19. U.S. Food and Drug Administration. [Depression medicines](https://www.fda.gov/media/132665/download#:~:text=Page%205,Feeling%20tired). 20. Gautam M, Tripathi A, Deshmukh D, Gaur M. [Cognitive behavioral therapy for depression](https://doi.org/10.4103/psychiatry.IndianJPsychiatry_772_19). *Indian J Psychiatry*. 2020;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry\_772\_19 21. Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW. [The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder](https://doi.org/10.1177/2045125317737264). *Ther Adv Psychopharmacol*. 2018;8(1):49-58. doi:10.1177/2045125317737264 22. Sansone RA, Sansone LA. [Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison](https://doi.org/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008300/). *Innov Clin Neurosci*. 2014;11(3-4):37-42. 23. Santarsieri D, Schwartz TL. [Antidepressant efficacy and side-effect burden: a quick guide for clinicians](https://doi.org/10.7573/dic.212290). *Drugs Context*. 2015;4:212290. doi:10.7573/dic.212290 By [Nancy Schimelpfening](https://www.verywellmind.com/nancy-schimelpfening-ms-4781235) Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. [See Our Editorial Process](https://www.verywellmind.com/our-editorial-process-4778006) [Meet Our Review Board](https://www.verywellmind.com/review-board-4796494) Share Feedback Was this page helpful? Thanks for your feedback\! What is your feedback? 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By [Nancy Schimelpfening](https://www.verywellmind.com/nancy-schimelpfening-ms-4781235) Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Updated on February 17, 2026 Medically reviewed Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. [Learn more](https://www.verywellmind.com/review-board-4796494). by [Daniel B. Block, MD](https://www.verywellmind.com/daniel-block-md-4779186) ![Block](https://www.verywellmind.com/thmb/bqppKq4IVUTVsPMClzJADd5fs14=/200x200/filters:no_upscale\(\):max_bytes\(150000\):strip_icc\(\)/block-8924ca72ff94426d940e8f7e639e3942.jpg) Daniel B. Block, MD, is an award-winning, board-certified psychiatrist who operates a private practice in Pennsylvania. ### Key Takeaways - St. John's wort may help with mild depression but can cause serious side effects and drug interactions, so consult a doctor before use. - Omega-3 fatty acids, especially EPA, may help with mild to moderate depression, but supplements should not exceed 3 grams daily without a doctor's approval. - 5-HTP may boost serotonin levels and help with depression, but it can cause side effects and interact with medications. Antidepressant medication is only available by prescription. However, some over-the-counter (OTC) herbs and supplements can have mild mood-boosting effects that can help with mild to moderate depression. These OTC antidepressants aren't meant to replace empirically-proven treatments like medication and therapy. Instead, they work best when used alongside other treatments and healthy habits like regular exercise, good sleep, social support, and stress management. St. John's Wort. esemelwe/Getty Images ## What Are Over-the-Counter Antidepressants? Over-the-counter antidepressants are supplements that have mood-boosting properties and are available without a prescription. These OTC remedies are not primary treatments for depression and are usually only used if depression symptoms are mild to moderate. Some of the most commonly used options include: - St. John's wort - Omega-3 fatty acids - 5-HTP - SAMe - Rhodiola rosea - Vitamins and minerals like vitamin D and magnesium Over-the-counter antidepressants are not the same as prescription antidepressants. They aren't first-line treatment options and have not been proven as remedies for depression. That said, some research does show that these options might be helpful for mild to moderate symptoms, but you should always talk to your doctor first before trying them. Let's take a closer look at some of the research behind these OTC antidepressants. ## St. John's Wort [St. John's wort](https://www.verywellmind.com/st-johns-wort-a2-89959) has a long history of use, going back to ancient times. It has also become a popular depression remedy in the modern world. ### Does St. John's Wort Work For Depression? There is evidence in the medical literature that St. John's Wort may help relieve mild symptoms of depression. A review published in 2019 concluded that its effects were similar to tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRIs) but with milder side effects. The review also noted, however, that the evidence isn't strong enough to make a "robust conclusion." The National Center for Complementary and Integrative Health notes that St. John's wort does not offer consistent results for relieving depression. Because of this, it should not be used to postpone or replace seeing a doctor for depression treatment. ### How Much St. John's Wort Do You Need? Dosages of St. John's wort used in studies have been quite variable and are dependent upon the formulation of the herb or its extracts. In addition to consulting your doctor before use, always follow the manufacturer's directions for your chosen product. ### What to Be Aware Of If you take St. John's wort, it's important to be aware of: - **Side effects**: Always talk to your doctor before you begin taking St. John's wort, since side effects can occur and can sometimes be severe. While reported side effects are uncommon and rare, they include dry mouth, dizziness, constipation, gastrointestinal symptoms, and confusion. - **Drug interactions**: Medication interactions can have serious and sometimes fatal consequences. For instance, taking St. John's wort with HIV medications can cause the body to clear HIV medications at a much higher rate, making it possible for a resurgence of HIV viral counts in a previously stable person. - **Serotonin syndrome**: If St. John's wort is combined with a prescription selective serotonin reuptake inhibitor (SSRI), MAOI, or any other [medication that increases serotonin](https://www.verywellmind.com/medications-and-serotonin-syndrome-2584342), there is a risk for [serotonin syndrome](https://www.verywellmind.com/what-is-serotonin-syndrome-379651), which can be fatal. - **Sun sensitivity**: St. John's wort can make your skin more sensitive to the sun, so it's important to wear sunscreen. ## Omega-3 Fatty Acids Sharaff / Getty Images Omega-3 fatty acids are very important for health. They play a role in heart health and reducing inflammation, but some findings suggest that they may also influence mental health. There are three types of omega-3s: - Alpha-linolenic acid (ALA) - Eicosapentaenoic acid (EPA) - Docosahexaenoic acid (DHA) ### Do Omega-3 Fatty Acids Work For Depression? More research is needed to explore the connection, but some evidence suggests that omega-3s may help prevent or possibly alleviate mild to moderate depression. - EPA, which is found in fish and other seafood, seems to offer the greatest depression-fighting benefits. - A 2019 meta-analysis of 26 earlier studies found that omega-3 polyunsaturated fatty acids (PUFAs) had a beneficial effect on depression. While omega-3s offer promise, whether EPA or other omega-3s provide significant relief on their own remains unclear. Studies suggest that omega-3 supplements used in addition to standard antidepressant therapy resulted in the best outcomes. ### How Much Omega-3 Do You Need? Most Americans get the ALA they need from the foods they eat, along with smaller amounts of EPA and DHA. You can get adequate omega-3s by eating a varied diet that includes fish and other seafood, nuts, seeds, plant oils, and fortified foods such as certain juices, yogurts, eggs, and milk. No particular dosage is recommended at this time for depression. The FDA recommends not going over 3 grams per day without your doctor's permission due to a potential increase in the risk of bleeding. ### How to Get More Omega-3s Since our bodies can't make them from scratch, omega-3 fatty acids must be obtained from the foods that we eat or from supplements. Foods that are high in omega-3s include: - Fish (especially salmon, mackerel, tuna, sardines, and herring) - Nuts and seeds (including walnuts, chia seeds, and flax seeds) - Plant oils (including canola oil, soybean oil, and flaxseed oil) ### What to Be Aware Of If you decide to try taking supplemental omega-3s, there are a few things to be aware of: - **Stomach upset**: While omega-3 fatty acid supplements, generally derived from fish oil, are considered to be quite safe, some people may experience stomach upset and fishy burps with higher doses. - **Increased blood thinning**: Omega-3 supplements may increase the effects of blood-thinning medications. For those who opt to eat fish rather than take a supplement, the American Heart Association recommends two servings of fish per week for general health, which could be taken as a good minimum consumption level. ## 5-HTP Jynto / Wikimedia Commons / CC0 [5-HTP](https://www.verywellmind.com/5-htp-5-hydroxytryptophan-88320), or 5-hydroxytryptophan, is an amino acid that your body makes from a dietary amino acid called L-tryptophan. Since it may increase [serotonin](https://www.verywellmind.com/what-is-serotonin-425327), a neurotransmitter that is believed to be involved in mood regulation, it is thought that 5-HTP supplements might help relieve depression. 5-HTP does not occur naturally in foods, so you must take it as a supplement. The supplement is derived from the seeds of *Griffonia simplicifolia,* a plant native to Central and Western Africa*.* The body produces 5-HTP naturally as it converts L-tryptophan, but this ability is limited by the availability of an enzyme called tryptophan hydroxylase. Taking 5-HTP as a supplement bypasses this limitation, so there is more 5-HTP available for conversion to serotonin. ### Does 5-HTP Work For Depression? While better-quality studies are needed to firmly establish its [effectiveness as an antidepressant](https://www.verywellmind.com/5-htp-for-depression-1066521), a 2019 review found that there is some evidence that 5-HTP supplementation, along with creatine, may improve the effectiveness of SSRI medications in some cases. However, it's essential that you speak with your doctor before adding this or any other supplement to your treatment program. ### How Much 5-HTP Do You Need? In clinical studies, the typical dose of 5-HTP ranges from 50 mg per day to 400 mg per day. However, it is always best to consult your doctor before you begin taking any new supplement, and never take more than the packaging label directs. ### What to Be Aware Of 5-HTP is generally safe and well-tolerated, although side effects can occur. Some potential side effects include: - Diarrhea - Dizziness - Drowsiness - Feelings of anxiety - Muscular tenderness - Nausea - Sexual dysfunction 5-HTP can also lead to drug interactions when taken with some other medications, including antidepressants like SSRIs and MAOIs, tramadol, and dextromethorphan (DXM). 5-HTP could lead to a dangerous build-up of high serotonin levels if it is used in conjunction with other medicines that impact serotonin. ## SAMe NEUROtiker / Wikimedia Commons / Public Domain [SAMe](https://www.verywellmind.com/how-sam-e-can-benefit-mental-health-6745925) (S-adenosylmethionine) is produced in your body from the essential amino acid methionine and the energy-producing compound adenosine triphosphate (ATP). It can also be taken as a dietary supplement. SAMe plays a role in methylation, a process involved in the regulation of neurotransmitters like serotonin, so it could possibly play a role in depression. ### Does SAMe Work For Depression? Studies indicate that it may relieve depression as well as an older type of antidepressant called tricyclic antidepressants. ### How Much SAMe Do You Need? Follow the package directions or consult with your physician for an appropriate dose for you. ### What to Be Aware Of Potential side effects include: - Dizziness - Elevated levels of homocysteine (a protein that has been linked to cardiovascular problems) - Gastrointestinal symptoms - Loss of appetite - Problems sleeping It is also important to note that SAMe may worsen [symptoms of mania](https://www.verywellmind.com/symptoms-of-mania-380311) in people with bipolar disorder. ## Rhodiola Rosea Daderot / Wikimedia Commons / Public Domain Although not much English-language research is currently available on [Rhodiola rosea](https://www.verywellmind.com/how-is-rhodiola-rosea-used-to-treat-anxiety-3024972), it has been used traditionally as a tonic in Norway, Sweden, Iceland, and Russia as an herbal antidepressant and stress-reliever. In addition, it has long been used by herbalists as an adaptogen, meaning it is thought to help people better cope with the effects of stress. ### Does Rhodiola Rosea Work For Depression? According to a 2016 review, there were very few clinical trials examining Rhodiola rosea's effects on depression. They were quite limited in their design and ability to determine outcomes. However, it appears to be well-tolerated, at least in short-term use. One 2018 study found that Rhodiola rosea extract helped improve symptoms of [stress-related burnout](https://www.verywellmind.com/stress-and-burnout-symptoms-and-causes-3144516), including depression. While American and European research is still in its early stages, this herb does appear to have some action as an antidepressant, and it has a good safety record. ### How Much Rhodiola Rosea Do You Need? In clinical studies, doses range from 100 mg to 400 mg daily. However, it's best to consult your doctor before you start taking Rhodiola rosea, and never exceed the manufacturer's dosage recommendations. ### What to Be Aware Of At low doses, most people do not experience side effects when taking Rhodiola rosea. However, you should consult your doctor if you plan to start taking Rhodiola rosea and you're taking the following medications: - Anti-anxiety medication - Prescription antidepressants - Antibiotics - Thyroid medication - Medications to treat diabetes - Birth control pills ## Vitamins and Minerals Brian Hagiwara Photolibrary / Getty Images A wide variety of vitamins and minerals have been investigated for their potential role in depression. These include vitamin B12, [chromium](https://www.verywellmind.com/chromium-for-depression-1066922), and inositol. It is not possible within the scope of this article to give full details about all of the nutritional factors involved in depression. ### Do Vitamins and Minerals Work For Depression? One meta-analysis suggested that the typical Western diet (which includes larger amounts of red/processed meats, refined sugars, and high-fat dairy) was associated with an increased risk of depression. Healthy diets that included a high intake of vegetables, fruit, whole grains, low-fat dairy, and fish, on the other hand, were linked to a decreased risk of depression. ### How Many Vitamins and Minerals Do You Need? In general, an adequate, well-balanced diet will provide all of the vitamins and minerals needed for good health and emotional balance. Alternatively, vitamin and mineral supplements may help fill the gaps. Please see your doctor if you have particular concerns about a vitamin or mineral deficiency. ### What to Be Aware Of A [healthy diet](https://www.verywellmind.com/vitamin-for-depression-1065211) is always a good place to start, no matter what health condition you're experiencing. However, vitamins and minerals alone can't reverse major depression. If you have severe symptoms of depression and/or symptoms that have been going on for more than a couple of weeks, seeing a mental health care professional should be your next step. ## Before Taking Over-the-Counter Antidepressants There are a few things to remember before you decide to try over-the-counter antidepressants: - **They don't replace other treatments.** Don't rely on over-the-counter remedies in place of proven treatments. While OTC antidepressants may help improve mood and help with some mild to moderate depression symptoms, they are not a replacement for antidepressants or therapy. - **They can cause interactions**. Just because something is 'natural' doesn't mean it won't cause side effects or pose risks. OTC supplements can have unpleasant side effects or interact with prescription medications. This is why it's important to tell your doctor about any medications and supplements you are taking. - **Their quality can vary**. Herbal supplements and vitamins are not subjected to the same quality control standards as prescription medications. That means that the quality and effectiveness of herbal supplements can vary considerably from one brand to another. ## Prescription vs. Over-the-Counter Antidepressants It's important to know that prescription antidepressants have gone through extensive testing to evaluate their safety and efficacy. They are held to much higher standards than over-the-counter antidepressants. Supplements do not require approval from the U.S. Food and Drug Administration. That means they are much easier to access, but also means it's harder to know whether the product you are getting is safe, effective, and correctly labeled. Prescription antidepressants, on the other hand, have a strong body of evidence showing that they are effective. This is why they are considered a first-line treatment for depression. Prescription Antidepressants - Examples include Prozac, Zoloft, and Cymbalta - FDA-approved (although some may be used off-label) - Strong evidence of efficacy - Standardized doses - Best for moderate to severe depression OTC Antidepressants - Examples include St. John's wort, SAMe, and 5-HTP - Not FDA-approved for depression - Limited to moderate evidence of efficacy - Varies by brand - Best for mild to moderate depression ## Seeking Professional Help If you find that OTC options do not alleviate your symptoms, talk to a doctor or mental health professional. In many cases, depression can be effectively treated with therapy and medication. ### Therapy Your doctor may recommend that you attend therapy. [Cognitive behavioral therapy](https://www.verywellmind.com/what-is-cognitive-behavior-therapy-2795747) (CBT) is a common therapy type used to treat depression. During CBT, a therapist will help you reframe negative thoughts and behaviors and teach you [healthy coping mechanisms](https://www.verywellmind.com/forty-healthy-coping-skills-4586742) to help alleviate symptoms of depression. ### Medication In order to get a prescription medication for depression, you must visit a doctor or mental health professional. If they determine you'd benefit from an antidepressant, they may prescribe a [selective serotonin reuptake inhibitor](https://www.verywellmind.com/list-of-ssris-380594) (SSRI). SSRIs work by increasing the amount of serotonin in the brain, which can help improve your sense of well-being and regulate your mood. Examples of SSRIs include: - Trintellix (vortioxetine) - [Zoloft](https://www.verywellmind.com/zoloft-sertraline-2584329) (sertraline) - [Prozac](https://www.verywellmind.com/how-is-prozac-used-to-treat-social-anxiety-disorder-3024962) (fluoxetine) - [Lexapro](https://www.verywellmind.com/anxiety-treatment-and-lexapro-dosage-and-side-effects-3024961) (escitalopram) Or, a doctor may prescribe a [serotonin-norepinephrine reuptake inhibitor](https://www.verywellmind.com/serotonin-and-norepinephrine-reuptake-inhibitors-snris-2584366) (SNRI) such as [Effexor](https://www.verywellmind.com/about-effexor-venlafaxine-378783) (venlafaxine). SSRIs and SNRIs may produce side effects such as anxiety, stomach aches, diarrhea, loss of appetite, and dizziness. Be sure to talk to a doctor if you experience these or any other side effects when taking any type of medication for depression. 23 Sources Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https://www.verywellmind.com/our-editorial-process-4778006) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. 1. Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. [Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action](https://doi.org/10.1002/jcp.27781). *J Cell Physiol*. 2019;234(6):8496-8508. doi:10.1002/jcp.27781 2. National Center for Complementary and Integrative Health. [St. John's wort and depression: In-depth](https://www.nccih.nih.gov/health/st-johns-wort-and-depression-in-depth). 3. de Wit L, Jeurissen S, [Chen W. Risk assessment of herbal preparations containing St John's wort](https://rivm.openrepository.com/bitstream/handle/10029/624775/2019-0115.pdf?sequence=1). National Institute for Public Health and the Environment Ministry of Health, Welfare and Sport. 2019. 4. Wani AL, Bhat SA, Ara A. [Omega-3 fatty acids and the treatment of depression: A review of scientific evidence](https://doi.org/10.1016/j.imr.2015.07.003). *Integr Med Res*. 2015;4(3):132-141. doi:10.1016/j.imr.2015.07.003 5. Liao Y, Xie B, Zhang H, et al. [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https://doi.org/10.1038/s41398-019-0515-5). *Transl Psychiatry*. 2019;9(1):190. doi:10.1038/s41398-019-0515-5 6. Burhani MD, Rasenick MM. [Fish oil and depression: The skinny on fats](https://doi.org/10.3233/JIN-170072). *J Integr Neurosci*. 2017;16(s1):S115-S124. doi:10.3233/JIN-170072 7. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for consumers](https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/). 8. National Institutes of Health Office of Dietary Supplements. [Omega-3 fatty acids: Fact sheet for health professionals](https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/). 9. American Heart Association. [Fish and omega-3 fatty acids](https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/fish-and-omega-3-fatty-acids). 10. Maffei ME. [5-Hydroxytryptophan (5-HTP): Natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology](https://doi.org/10.3390%2Fijms22010181). *Int J Mol Sci*. 2020;22(1):181. doi:10.3390/ijms22010181 11. Dome P, Tombor L, Lazary J, Gonda X, Rihmer Z. [Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: A review](https://doi.org/10.1016/j.brainresbull.2018.12.015). *Brain Res Bull*. 2019;146:51-78. doi:10.1016/j.brainresbull.2018.12.015 12. Javelle F, Lampit A, Bloch W, Häussermann P, Johnson SL, Zimmer P. [Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis](https://doi.org/10.1093/nutrit/nuz039). *Nutr Rev*. 2020;78(1):77-88. doi:10.1093/nutrit/nuz039 13. National Center for Complementary and Integrative Health. [S-adenosyl-l-methionine (SAMe): in depth](https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth). 14. Jagtap PN, Mhetre OS, Malavdkar PR. [A review article on Rhodiola rosea: An adaptogen having multiple benefits](https://ijpjournal.com/wp-content/uploads/2020/04/2-Vol.-7-Issue-3-Mar-2020-IJP-RE-271.pdf). *Int J Pharmacogn*. 2020;7:62-9. 15. Amsterdam JD, Panossian AG. [Rhodiola rosea L. as a putative botanical antidepressant](https://doi.org/10.1016/j.phymed.2016.02.009). *Phytomedicine*. 2016;23(7):770-83. doi:10.1016/j.phymed.2016.02.009 16. Kasper S, Dienel A. [Multicenter, open-label, exploratory clinical trial with *Rhodiola rosea* extract in patients suffering from burnout symptoms](https://doi.org/10.2147/NDT.S120113). *Neuropsychiatr Dis Treat*. 2017;13:889-898. doi:10.2147/NDT.S120113 17. Li Y, Lv MR, Wei YJ, et al. [Dietary patterns and depression risk: A meta-analysis](https://doi.org/10.1016/j.psychres.2017.04.020). *Psychiatry Res*. 2017;253:373-382. doi:10.1016/j.psychres.2017.04.020 18. U.S. Department of Health and Human Services and U.S. Department of Agriculture. [2015 – 2020 Dietary Guidelines for Americans. 8th Edition](https://health.gov/dietaryguidelines/2015/guidelines/). 19. U.S. Food and Drug Administration. [Depression medicines](https://www.fda.gov/media/132665/download#:~:text=Page%205,Feeling%20tired). 20. Gautam M, Tripathi A, Deshmukh D, Gaur M. [Cognitive behavioral therapy for depression](https://doi.org/10.4103/psychiatry.IndianJPsychiatry_772_19). *Indian J Psychiatry*. 2020;62(Suppl 2):S223-S229. doi:10.4103/psychiatry.IndianJPsychiatry\_772\_19 21. Clevenger SS, Malhotra D, Dang J, Vanle B, IsHak WW. [The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder](https://doi.org/10.1177/2045125317737264). *Ther Adv Psychopharmacol*. 2018;8(1):49-58. doi:10.1177/2045125317737264 22. Sansone RA, Sansone LA. [Serotonin norepinephrine reuptake inhibitors: a pharmacological comparison](https://doi.org/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008300/). *Innov Clin Neurosci*. 2014;11(3-4):37-42. 23. Santarsieri D, Schwartz TL. [Antidepressant efficacy and side-effect burden: a quick guide for clinicians](https://doi.org/10.7573/dic.212290). *Drugs Context*. 2015;4:212290. doi:10.7573/dic.212290 By [Nancy Schimelpfening](https://www.verywellmind.com/nancy-schimelpfening-ms-4781235) Nancy Schimelpfening, MS is the administrator for the non-profit depression support group Depression Sanctuary. Nancy has a lifetime of experience with depression, experiencing firsthand how devastating this illness can be. Was this page helpful? Thanks for your feedback\! What is your feedback?

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