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| Meta Title | What Is a Hypnic Jerk and What Causes Sleep Starts? |
| Meta Description | Hypnic jerks (sleep starts) cause a sudden, uncontrollable muscle twitch affecting your whole body or arms and legs. The twitch occurs as you fall asleep. |
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| Boilerpipe Text | Key Takeaways
Hypnic jerks are common, sudden muscle twitches that happen when you fall asleep.
Stress, anxiety, and fatigue can increase the chances of experiencing sleep starts.
Sleep starts are harmless but can sometimes cause worry about falling asleep.
A hypnic (hypnagogic) jerk is a sudden, uncontrollable muscle twitch that occurs as you fall asleep. These twitches, also called sleep starts, are common, harmless, and often triggered by lifestyle issues like stress, anxiety, and fatigue. They also mimic the symptoms of some health conditions.
Justin Case / The Image Bank / Getty Images
Why Do Your Muscles Suddenly Spasm As You Fall Asleep?
Hypnic jerks (hypnagogic jerks) affect up to 70% percent of people.
1
These sudden, rapid, uncontrollable muscle twitches, known as sleep starts, occur when you first fall asleep, as you transition from wakefulness to sleep.
2
Why your muscles suddenly twitch is still being studied. However, the current evidence suggests that it's due to a miscommunication between nerves, causing a misfire in your brain that leads to a sudden muscle contraction.
You may also hear hypnic jerks called sleep or physiologic myoclonus, Myoclonus refers to uncontrollable muscle twitches and spasms. Physiologic myoclonus occurs in healthy people. Other types of myoclonus are symptoms of an underlying health condition.
3
Does Everyone Have Similar Twitching Experiences?
During a hypnic jerk, most people have one strong, brief, contraction affecting most or all of their body's muscles. However, the twitch may affect a few muscles groups, with the arms and legs being the most common.
Some people may experience other sensations during a sleep start, such as:
4
Feeling of falling
Startled feeling
Flash of light
Vocalization (sharp cry)
Vivid images or brief hallucination (seeing, hearing, or feeling something that isn't there)
5
Could Your Lifestyle Trigger Sleep Starts?
Your chances of hypnic jerks are higher if you have or do any of the following:
2
Anxiety
Stress
Sleep deprivation
Drink caffeine or smoke (both are stimulants)
Physical exhaustion
Vigorous exercise close to bedtime
Though most people aren't bothered by sleep starts, the hypnic jerk episodes may lead to anxiety about falling asleep and
insomnia
. This is especially likely if a related hallucination is upsetting (such as falling from a great height) and remembered.
Can Sleep Starts Signal Another Health Concern?
There are other conditions that may cause twitchy movements (myoclonus) whether you're asleep or awake. These include:
2
6
Restless leg syndrome (RLS)
: RLS causes uncomfortable feelings in the legs, like itching, crawling, and tingling, along with the uncontrollable urge to move your legs. These sensations occur when you're resting or trying to fall asleep.
6
Periodic limb movement disorder (PLMD)
: This condition causes your legs and arms to move repeatedly and uncontrollably while you sleep. While people with RLS have periodic limb movements, those with PLMD do not necessarily have RLS.
7
Pathologic myoclonus
: This type of myoclonus occurs when a brain or nerve disorder causes persistent and severe muscle contractions. Epilepsy, Parkinson's disease, brain tumors, stroke, multiple sclerosis, Alzheimer's disease, and dementia with Lewy bodies are a few examples of neurologic conditions that can cause pathologic myoclonus.
3
Fasciculation syndrome
: Fasciculation occurs when a specific muscle or group of muscles twitch, often during waking hours. This occurs in about 70% of people.
8
Metabolic disorders:
Metabolic disorders
are conditions that disrupt some aspect of the body's essential biochemical processes, such as producing proteins and energy, building bones, and using nutrients. Three of the most common metabolic disorders that can cause muscle twitches are liver disease, kidney disease, and
electrolyte imbalances
.
3
Medications:
Numerous medications may trigger or worsen sleep myoclonus. For example, certain antibiotics, antidepressants, anti-seizure medications, mood stabilizers, and atypical antipsychotics cause medication-induced myoclonus (MIM). Opioids like fentanyl and morphine can also cause MIM.
9
Infections:
Some bacterial, viral, and fungal infections may cause sleep myoclonus. A few of the most common include measles, rubella, Lyme disease,
human immunodeficiency virus (HIV)
, COVID-19, and
herpes simplex virus
.
10
Trauma
: An injury to your head or spinal cord may cause nerve damage leading to myoclonus.
Cancer:
Certain cancers, such as
neuroblastoma
and lung and breast cancer, may cause myoclonus.
3
Seizures can lead to jerky or twitching motion, depending on the
type of seizure
. You also may experience symptoms similar to hypnic jerks due to:
4
Another sleep disorder, such as
sleep apnea
(this can be ruled out with a
sleep study
)
A medical condition. A 2021 study found hypnic jerks were more common during COVID-19 lockdowns in autistic children, for example, when compared with the general population.
11
Medication use, such as serotonin reuptake inhibitors (
SSRIs
)
2
A mental health disorder
Substance abuse
Sleep Starts vs. Other Conditions
Sleep starts have several characteristics that distinguish them from other conditions. Of those, timing is one of the easiest to identify.
Hypnic jerks occur as you fall asleep. RLS also begins when you rest, but its symptoms are distinct from sleep starts. PLMD occurs nearly constantly while sleeping. Pathologic myoclonus isn’t limited to sleep; the twitches occur while you’re awake.
Another difference is that hypnic jerks seldom interfere with your sleep. The other conditions mentioned above frequently disrupt sleep.
Do You Need Treatment for Hypnic Jerks?
In general, it is not necessary to seek testing or treatment for sleep starts. These muscle twitches are common, ordinary, and seldom signify a health concern.
You will need treatment if your muscle twitches are caused by another condition. Then, the treatment depends on your diagnosis.
However, if hypnic jerks occur frequently and disrupt your sleep, the American Academy of Sleep Medicine recommends that you take steps to change any lifestyle habits that may trigger the problem. This may include:
4
Learning how to manage stress
Seeking treatment for anxiety
Avoiding caffeine
and other stimulants in the hours before bedtime
Scheduling exercise early in the day
Improving your sleep habits
Improving your sleep environment includes following a relaxing bedtime routine, turning off lights and electronics (the light affects your sleep-wake cycle), and keeping your room at a comfortable temperature.
11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our
editorial process
to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
Alghamdi SA.
Hypnic jerks, major depressive disorder, and antidepressant use: a possible relationship
.
Cureus
. 2023 Oct 21;15(10):e47436. doi:10.7759/cureus.47436
Kumar R, Ali SN, Saha S, Bhattacharjee S.
SSRI induced hypnic jerks: a case series
.
Indian J Psychiatry
. 2023 Jul;65(7):785-788. doi:10.4103/indianjpsychiatry.indianjpsychiatry_207_23
National Institute of Neurological Disorders and Stroke.Â
Myoclonus
.
American Academy of Sleep Medicine.
Sleep starts
.
Waters F, Ling I, Azimi S, Blom JD.
Sleep-related hallucinations
.
Sleep Med Clin
. 2024 Mar;19(1):143-157. doi:10.1016/j.jsmc.2023.10.008
Winkelman JW, Berkowski JA, DelRosso LM, Koo BB, Scharf MT, Sharon D, et al.
Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline
.
J Clin Sleep Med
. 2025 Jan 1;21(1):137-152. doi:10.5664/jcsm.11390
National Institute of Neurological Disorders and Stroke.
Restless legs syndrome.
Filippakas A, Jara J, Ventura N, et al.Â
A prospective study of benign fasciculation syndrome and anxiety
.Â
Neurology
. 2017;88(16 Supp):852-4. doi:10.1002/mus.26193
Rissardo JP, Fornari Caprara AL, Bhal N, et al.
Drug-Induced Myoclonus: A Systematic Review.
Medicina (Kaunas).
2025 Jan 15;61(1):131. doi:10.3390/medicina61010131.
Kothiala, Apara, Â Shankar, Vijay, Desai, Soaham
,
.Â
Myoclonus associated with infections: A narrative review.
Annals of Movement Disorders
5(3):p 137-152, Sep–Dec 2022. DOI:10.4103/AOMD.AOMD_25_22
Bruni O, Breda M, Ferri R, Melegari MG.
Changes in sleep patterns and disorders in children and adolescents with attention deficit hyperactivity disorders and autism spectrum disorders during the COVID-19 lockdown
.
Brain Sci
. 2021 Aug 27;11(9):1139. doi:10.3390/brainsci11091139
By
Brandon Peters, MD
Dr. Peters is a board-certified neurologist and sleep medicine specialist and is a fellow of the American Academy of Sleep Medicine.
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# Why Do Hypnic Jerks Make Muscles Twitch When Falling Asleep?
By [Brandon Peters, MD](https://www.verywellhealth.com/brandon-peters-md-3014640)
Updated on December 08, 2025
Medically reviewed by [Arno Kroner, DAOM](https://www.verywellhealth.com/arno-kroner-daom-lac-4797488)
Table of Contents
View All
Table of Contents
- [Hypnic Jerk Causes](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-why-do-your-muscles-suddenly-spasm-as-you-fall-asleep)
- [Sensations Along With Sleep Starts](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-does-everyone-have-similar-twitching-experiences)
- [Lifestyle Triggers](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-could-your-lifestyle-trigger-sleep-starts)
- [Other Conditions](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-can-sleep-starts-signal-another-health-concern)
- [Hypnic Jerks vs. Other Conditions](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-sleep-starts-vs-other-conditions)
- [Treatment](https://www.verywellhealth.com/what-is-a-hypnagogic-jerk-and-what-causes-sleep-starts-3014889#toc-do-you-need-treatment-for-hypnic-jerks)
### Key Takeaways
- Hypnic jerks are common, sudden muscle twitches that happen when you fall asleep.
- Stress, anxiety, and fatigue can increase the chances of experiencing sleep starts.
- Sleep starts are harmless but can sometimes cause worry about falling asleep.
A hypnic (hypnagogic) jerk is a sudden, uncontrollable muscle twitch that occurs as you fall asleep. These twitches, also called sleep starts, are common, harmless, and often triggered by lifestyle issues like stress, anxiety, and fatigue. They also mimic the symptoms of some health conditions.
:max_bytes\(150000\):strip_icc\(\)/142010707_HighRes-56a884b03df78cf7729e838a.jpg)
:max_bytes\(150000\):strip_icc\(\)/142010707_HighRes-56a884b03df78cf7729e838a.jpg)
Justin Case / The Image Bank / Getty Images
## Why Do Your Muscles Suddenly Spasm As You Fall Asleep?
Hypnic jerks (hypnagogic jerks) affect up to 70% percent of people.1 These sudden, rapid, uncontrollable muscle twitches, known as sleep starts, occur when you first fall asleep, as you transition from wakefulness to sleep.2
Why your muscles suddenly twitch is still being studied. However, the current evidence suggests that it's due to a miscommunication between nerves, causing a misfire in your brain that leads to a sudden muscle contraction.
You may also hear hypnic jerks called sleep or physiologic myoclonus, Myoclonus refers to uncontrollable muscle twitches and spasms. Physiologic myoclonus occurs in healthy people. Other types of myoclonus are symptoms of an underlying health condition.3
## Does Everyone Have Similar Twitching Experiences?
During a hypnic jerk, most people have one strong, brief, contraction affecting most or all of their body's muscles. However, the twitch may affect a few muscles groups, with the arms and legs being the most common.
Some people may experience other sensations during a sleep start, such as:4
- Feeling of falling
- Startled feeling
- Flash of light
- Vocalization (sharp cry)
- Vivid images or brief hallucination (seeing, hearing, or feeling something that isn't there)5
## Could Your Lifestyle Trigger Sleep Starts?
Your chances of hypnic jerks are higher if you have or do any of the following:2
- [Anxiety](https://www.verywellhealth.com/anxiety-disorders-5205106)
- Stress
- Sleep deprivation
- Drink caffeine or smoke (both are stimulants)
- Physical exhaustion
- Vigorous exercise close to bedtime
Though most people aren't bothered by sleep starts, the hypnic jerk episodes may lead to anxiety about falling asleep and [insomnia](https://www.verywellhealth.com/what-is-insomnia-the-features-symptoms-and-causes-3014805). This is especially likely if a related hallucination is upsetting (such as falling from a great height) and remembered.
## Can Sleep Starts Signal Another Health Concern?
There are other conditions that may cause twitchy movements (myoclonus) whether you're asleep or awake. These include:26
- [**Restless leg syndrome (RLS)**](https://www.verywellhealth.com/restless-legs-syndrome-multiple-sclerosis-2440812): RLS causes uncomfortable feelings in the legs, like itching, crawling, and tingling, along with the uncontrollable urge to move your legs. These sensations occur when you're resting or trying to fall asleep.6
- **Periodic limb movement disorder (PLMD)**: This condition causes your legs and arms to move repeatedly and uncontrollably while you sleep. While people with RLS have periodic limb movements, those with PLMD do not necessarily have RLS.7
- **Pathologic myoclonus**: This type of myoclonus occurs when a brain or nerve disorder causes persistent and severe muscle contractions. Epilepsy, Parkinson's disease, brain tumors, stroke, multiple sclerosis, Alzheimer's disease, and dementia with Lewy bodies are a few examples of neurologic conditions that can cause pathologic myoclonus.3
- [**Fasciculation syndrome**](https://www.verywellhealth.com/benign-fasciculation-syndromes-2488771): Fasciculation occurs when a specific muscle or group of muscles twitch, often during waking hours. This occurs in about 70% of people.8
- **Metabolic disorders:** [Metabolic disorders](https://www.verywellhealth.com/metabolic-syndrome-1745266) are conditions that disrupt some aspect of the body's essential biochemical processes, such as producing proteins and energy, building bones, and using nutrients. Three of the most common metabolic disorders that can cause muscle twitches are liver disease, kidney disease, and [electrolyte imbalances](https://www.verywellhealth.com/electrolyte-imbalances-4800164).3
- **Medications:** Numerous medications may trigger or worsen sleep myoclonus. For example, certain antibiotics, antidepressants, anti-seizure medications, mood stabilizers, and atypical antipsychotics cause medication-induced myoclonus (MIM). Opioids like fentanyl and morphine can also cause MIM.9
- **Infections:** Some bacterial, viral, and fungal infections may cause sleep myoclonus. A few of the most common include measles, rubella, Lyme disease, [human immunodeficiency virus (HIV)](https://www.verywellhealth.com/hiv-aids-5216828), COVID-19, and [herpes simplex virus](https://www.verywellhealth.com/hsv-1-vs-hsv-2-7092956).10
- **Trauma**: An injury to your head or spinal cord may cause nerve damage leading to myoclonus.
- **Cancer:** Certain cancers, such as [neuroblastoma](https://www.verywellhealth.com/neuroblastoma-overview-5197561) and lung and breast cancer, may cause myoclonus.3
Seizures can lead to jerky or twitching motion, depending on the [type of seizure](https://www.verywellhealth.com/seizures-7546651). You also may experience symptoms similar to hypnic jerks due to:4
- Another sleep disorder, such as [sleep apnea](https://www.verywellhealth.com/sleep-apnea-overview-3014774) (this can be ruled out with a [sleep study](https://www.verywellhealth.com/what-to-expect-in-a-sleep-study-3015121))
- A medical condition. A 2021 study found hypnic jerks were more common during COVID-19 lockdowns in autistic children, for example, when compared with the general population.11
- Medication use, such as serotonin reuptake inhibitors ([SSRIs](https://www.verywellhealth.com/ssris-vs-snris-5193051))2
- A mental health disorder
- Substance abuse
## Sleep Starts vs. Other Conditions
Sleep starts have several characteristics that distinguish them from other conditions. Of those, timing is one of the easiest to identify.
Hypnic jerks occur as you fall asleep. RLS also begins when you rest, but its symptoms are distinct from sleep starts. PLMD occurs nearly constantly while sleeping. Pathologic myoclonus isn’t limited to sleep; the twitches occur while you’re awake.
Another difference is that hypnic jerks seldom interfere with your sleep. The other conditions mentioned above frequently disrupt sleep.
## Do You Need Treatment for Hypnic Jerks?
In general, it is not necessary to seek testing or treatment for sleep starts. These muscle twitches are common, ordinary, and seldom signify a health concern.
You will need treatment if your muscle twitches are caused by another condition. Then, the treatment depends on your diagnosis.
However, if hypnic jerks occur frequently and disrupt your sleep, the American Academy of Sleep Medicine recommends that you take steps to change any lifestyle habits that may trigger the problem. This may include:4
- Learning how to manage stress
- Seeking treatment for anxiety
- [Avoiding caffeine](https://www.verywellmind.com/caffeine-stress-and-your-health-3145078) and other stimulants in the hours before bedtime
- Scheduling exercise early in the day
- [Improving your sleep habits](https://www.verywellhealth.com/sleep-hygiene-8717173)
Improving your sleep environment includes following a relaxing bedtime routine, turning off lights and electronics (the light affects your sleep-wake cycle), and keeping your room at a comfortable temperature.
Read more:
- [Health A-Z](https://www.verywellhealth.com/health-a-z-4014770)
- [Sleep Disorders](https://www.verywellhealth.com/sleep-disorders-4014648)
11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https://www.verywellhealth.com/verywell-editorial-process-4777042) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
1. Alghamdi SA. [Hypnic jerks, major depressive disorder, and antidepressant use: a possible relationship](https://pmc.ncbi.nlm.nih.gov/articles/PMC10590197/). *Cureus*. 2023 Oct 21;15(10):e47436. doi:10.7759/cureus.47436
2. Kumar R, Ali SN, Saha S, Bhattacharjee S. [SSRI induced hypnic jerks: a case series](https://pmc.ncbi.nlm.nih.gov/articles/PMC10461585/). *Indian J Psychiatry*. 2023 Jul;65(7):785-788. doi:10.4103/indianjpsychiatry.indianjpsychiatry\_207\_23
3. National Institute of Neurological Disorders and Stroke. [Myoclonus](https://www.ninds.nih.gov/health-information/disorders/myoclonus).
4. American Academy of Sleep Medicine. [Sleep starts](https://sleepeducation.org/sleep-disorders/sleep-starts/).
5. Waters F, Ling I, Azimi S, Blom JD. [Sleep-related hallucinations](https://pubmed.ncbi.nlm.nih.gov/38368061/). *Sleep Med Clin*. 2024 Mar;19(1):143-157. doi:10.1016/j.jsmc.2023.10.008
6. Winkelman JW, Berkowski JA, DelRosso LM, Koo BB, Scharf MT, Sharon D, et al. [Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline](https://pubmed.ncbi.nlm.nih.gov/39324694/). *J Clin Sleep Med*. 2025 Jan 1;21(1):137-152. doi:10.5664/jcsm.11390
7. National Institute of Neurological Disorders and Stroke. [Restless legs syndrome.](https://www.ninds.nih.gov/health-information/disorders/restless-legs-syndrome)
8. Filippakas A, Jara J, Ventura N, et al. [A prospective study of benign fasciculation syndrome and anxiety](https://doi.org/10.1002/mus.26193). *Neurology*. 2017;88(16 Supp):852-4. doi:10.1002/mus.26193
9. Rissardo JP, Fornari Caprara AL, Bhal N, et al. [Drug-Induced Myoclonus: A Systematic Review.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11767161/) *Medicina (Kaunas).* 2025 Jan 15;61(1):131. doi:10.3390/medicina61010131.
10. Kothiala, Apara, Shankar, Vijay, Desai, Soaham,. [Myoclonus associated with infections: A narrative review.](https://journals.lww.com/aomd/fulltext/2022/05030/myoclonus_associated_with_infections__a_narrative.1.aspx) *Annals of Movement Disorders* 5(3):p 137-152, Sep–Dec 2022. DOI:10.4103/AOMD.AOMD\_25\_22
11. Bruni O, Breda M, Ferri R, Melegari MG. [Changes in sleep patterns and disorders in children and adolescents with attention deficit hyperactivity disorders and autism spectrum disorders during the COVID-19 lockdown](https://pmc.ncbi.nlm.nih.gov/articles/PMC8469743/). *Brain Sci*. 2021 Aug 27;11(9):1139. doi:10.3390/brainsci11091139
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Dr. Peters is a board-certified neurologist and sleep medicine specialist and is a fellow of the American Academy of Sleep Medicine.
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| Readable Markdown | ### Key Takeaways
- Hypnic jerks are common, sudden muscle twitches that happen when you fall asleep.
- Stress, anxiety, and fatigue can increase the chances of experiencing sleep starts.
- Sleep starts are harmless but can sometimes cause worry about falling asleep.
A hypnic (hypnagogic) jerk is a sudden, uncontrollable muscle twitch that occurs as you fall asleep. These twitches, also called sleep starts, are common, harmless, and often triggered by lifestyle issues like stress, anxiety, and fatigue. They also mimic the symptoms of some health conditions.
Justin Case / The Image Bank / Getty Images
## Why Do Your Muscles Suddenly Spasm As You Fall Asleep?
Hypnic jerks (hypnagogic jerks) affect up to 70% percent of people.1 These sudden, rapid, uncontrollable muscle twitches, known as sleep starts, occur when you first fall asleep, as you transition from wakefulness to sleep.2
Why your muscles suddenly twitch is still being studied. However, the current evidence suggests that it's due to a miscommunication between nerves, causing a misfire in your brain that leads to a sudden muscle contraction.
You may also hear hypnic jerks called sleep or physiologic myoclonus, Myoclonus refers to uncontrollable muscle twitches and spasms. Physiologic myoclonus occurs in healthy people. Other types of myoclonus are symptoms of an underlying health condition.3
## Does Everyone Have Similar Twitching Experiences?
During a hypnic jerk, most people have one strong, brief, contraction affecting most or all of their body's muscles. However, the twitch may affect a few muscles groups, with the arms and legs being the most common.
Some people may experience other sensations during a sleep start, such as:4
- Feeling of falling
- Startled feeling
- Flash of light
- Vocalization (sharp cry)
- Vivid images or brief hallucination (seeing, hearing, or feeling something that isn't there)5
## Could Your Lifestyle Trigger Sleep Starts?
Your chances of hypnic jerks are higher if you have or do any of the following:2
- [Anxiety](https://www.verywellhealth.com/anxiety-disorders-5205106)
- Stress
- Sleep deprivation
- Drink caffeine or smoke (both are stimulants)
- Physical exhaustion
- Vigorous exercise close to bedtime
Though most people aren't bothered by sleep starts, the hypnic jerk episodes may lead to anxiety about falling asleep and [insomnia](https://www.verywellhealth.com/what-is-insomnia-the-features-symptoms-and-causes-3014805). This is especially likely if a related hallucination is upsetting (such as falling from a great height) and remembered.
## Can Sleep Starts Signal Another Health Concern?
There are other conditions that may cause twitchy movements (myoclonus) whether you're asleep or awake. These include:26
- [**Restless leg syndrome (RLS)**](https://www.verywellhealth.com/restless-legs-syndrome-multiple-sclerosis-2440812): RLS causes uncomfortable feelings in the legs, like itching, crawling, and tingling, along with the uncontrollable urge to move your legs. These sensations occur when you're resting or trying to fall asleep.6
- **Periodic limb movement disorder (PLMD)**: This condition causes your legs and arms to move repeatedly and uncontrollably while you sleep. While people with RLS have periodic limb movements, those with PLMD do not necessarily have RLS.7
- **Pathologic myoclonus**: This type of myoclonus occurs when a brain or nerve disorder causes persistent and severe muscle contractions. Epilepsy, Parkinson's disease, brain tumors, stroke, multiple sclerosis, Alzheimer's disease, and dementia with Lewy bodies are a few examples of neurologic conditions that can cause pathologic myoclonus.3
- [**Fasciculation syndrome**](https://www.verywellhealth.com/benign-fasciculation-syndromes-2488771): Fasciculation occurs when a specific muscle or group of muscles twitch, often during waking hours. This occurs in about 70% of people.8
- **Metabolic disorders:** [Metabolic disorders](https://www.verywellhealth.com/metabolic-syndrome-1745266) are conditions that disrupt some aspect of the body's essential biochemical processes, such as producing proteins and energy, building bones, and using nutrients. Three of the most common metabolic disorders that can cause muscle twitches are liver disease, kidney disease, and [electrolyte imbalances](https://www.verywellhealth.com/electrolyte-imbalances-4800164).3
- **Medications:** Numerous medications may trigger or worsen sleep myoclonus. For example, certain antibiotics, antidepressants, anti-seizure medications, mood stabilizers, and atypical antipsychotics cause medication-induced myoclonus (MIM). Opioids like fentanyl and morphine can also cause MIM.9
- **Infections:** Some bacterial, viral, and fungal infections may cause sleep myoclonus. A few of the most common include measles, rubella, Lyme disease, [human immunodeficiency virus (HIV)](https://www.verywellhealth.com/hiv-aids-5216828), COVID-19, and [herpes simplex virus](https://www.verywellhealth.com/hsv-1-vs-hsv-2-7092956).10
- **Trauma**: An injury to your head or spinal cord may cause nerve damage leading to myoclonus.
- **Cancer:** Certain cancers, such as [neuroblastoma](https://www.verywellhealth.com/neuroblastoma-overview-5197561) and lung and breast cancer, may cause myoclonus.3
Seizures can lead to jerky or twitching motion, depending on the [type of seizure](https://www.verywellhealth.com/seizures-7546651). You also may experience symptoms similar to hypnic jerks due to:4
- Another sleep disorder, such as [sleep apnea](https://www.verywellhealth.com/sleep-apnea-overview-3014774) (this can be ruled out with a [sleep study](https://www.verywellhealth.com/what-to-expect-in-a-sleep-study-3015121))
- A medical condition. A 2021 study found hypnic jerks were more common during COVID-19 lockdowns in autistic children, for example, when compared with the general population.11
- Medication use, such as serotonin reuptake inhibitors ([SSRIs](https://www.verywellhealth.com/ssris-vs-snris-5193051))2
- A mental health disorder
- Substance abuse
## Sleep Starts vs. Other Conditions
Sleep starts have several characteristics that distinguish them from other conditions. Of those, timing is one of the easiest to identify.
Hypnic jerks occur as you fall asleep. RLS also begins when you rest, but its symptoms are distinct from sleep starts. PLMD occurs nearly constantly while sleeping. Pathologic myoclonus isn’t limited to sleep; the twitches occur while you’re awake.
Another difference is that hypnic jerks seldom interfere with your sleep. The other conditions mentioned above frequently disrupt sleep.
## Do You Need Treatment for Hypnic Jerks?
In general, it is not necessary to seek testing or treatment for sleep starts. These muscle twitches are common, ordinary, and seldom signify a health concern.
You will need treatment if your muscle twitches are caused by another condition. Then, the treatment depends on your diagnosis.
However, if hypnic jerks occur frequently and disrupt your sleep, the American Academy of Sleep Medicine recommends that you take steps to change any lifestyle habits that may trigger the problem. This may include:4
- Learning how to manage stress
- Seeking treatment for anxiety
- [Avoiding caffeine](https://www.verywellmind.com/caffeine-stress-and-your-health-3145078) and other stimulants in the hours before bedtime
- Scheduling exercise early in the day
- [Improving your sleep habits](https://www.verywellhealth.com/sleep-hygiene-8717173)
Improving your sleep environment includes following a relaxing bedtime routine, turning off lights and electronics (the light affects your sleep-wake cycle), and keeping your room at a comfortable temperature.
11 Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our [editorial process](https://www.verywellhealth.com/verywell-editorial-process-4777042) to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
1. Alghamdi SA. [Hypnic jerks, major depressive disorder, and antidepressant use: a possible relationship](https://pmc.ncbi.nlm.nih.gov/articles/PMC10590197/). *Cureus*. 2023 Oct 21;15(10):e47436. doi:10.7759/cureus.47436
2. Kumar R, Ali SN, Saha S, Bhattacharjee S. [SSRI induced hypnic jerks: a case series](https://pmc.ncbi.nlm.nih.gov/articles/PMC10461585/). *Indian J Psychiatry*. 2023 Jul;65(7):785-788. doi:10.4103/indianjpsychiatry.indianjpsychiatry\_207\_23
3. National Institute of Neurological Disorders and Stroke. [Myoclonus](https://www.ninds.nih.gov/health-information/disorders/myoclonus).
4. American Academy of Sleep Medicine. [Sleep starts](https://sleepeducation.org/sleep-disorders/sleep-starts/).
5. Waters F, Ling I, Azimi S, Blom JD. [Sleep-related hallucinations](https://pubmed.ncbi.nlm.nih.gov/38368061/). *Sleep Med Clin*. 2024 Mar;19(1):143-157. doi:10.1016/j.jsmc.2023.10.008
6. Winkelman JW, Berkowski JA, DelRosso LM, Koo BB, Scharf MT, Sharon D, et al. [Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine clinical practice guideline](https://pubmed.ncbi.nlm.nih.gov/39324694/). *J Clin Sleep Med*. 2025 Jan 1;21(1):137-152. doi:10.5664/jcsm.11390
7. National Institute of Neurological Disorders and Stroke. [Restless legs syndrome.](https://www.ninds.nih.gov/health-information/disorders/restless-legs-syndrome)
8. Filippakas A, Jara J, Ventura N, et al. [A prospective study of benign fasciculation syndrome and anxiety](https://doi.org/10.1002/mus.26193). *Neurology*. 2017;88(16 Supp):852-4. doi:10.1002/mus.26193
9. Rissardo JP, Fornari Caprara AL, Bhal N, et al. [Drug-Induced Myoclonus: A Systematic Review.](https://pmc.ncbi.nlm.nih.gov/articles/PMC11767161/) *Medicina (Kaunas).* 2025 Jan 15;61(1):131. doi:10.3390/medicina61010131.
10. Kothiala, Apara, Shankar, Vijay, Desai, Soaham,. [Myoclonus associated with infections: A narrative review.](https://journals.lww.com/aomd/fulltext/2022/05030/myoclonus_associated_with_infections__a_narrative.1.aspx) *Annals of Movement Disorders* 5(3):p 137-152, Sep–Dec 2022. DOI:10.4103/AOMD.AOMD\_25\_22
11. Bruni O, Breda M, Ferri R, Melegari MG. [Changes in sleep patterns and disorders in children and adolescents with attention deficit hyperactivity disorders and autism spectrum disorders during the COVID-19 lockdown](https://pmc.ncbi.nlm.nih.gov/articles/PMC8469743/). *Brain Sci*. 2021 Aug 27;11(9):1139. doi:10.3390/brainsci11091139
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By [Brandon Peters, MD](https://www.verywellhealth.com/brandon-peters-md-3014640)
Dr. Peters is a board-certified neurologist and sleep medicine specialist and is a fellow of the American Academy of Sleep Medicine.
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