🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 3 (from laksa133)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa003.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical, ml_categories_json AS ml_categories_json, ml_types_json AS ml_types_json, ml_intent_types_json AS ml_intent_types_json, meta_language AS meta_language, attrs_author AS attrs_author, ifNull(toUnixTimestamp(attrs_publish_time), 0) AS attrs_publish_time, ifNull(toUnixTimestamp(attrs_original_publish_time), 0) AS attrs_original_publish_time, ifNull(attrs_is_republished, 0) AS attrs_is_republished, ifNull(attrs_nr_words, 0) AS attrs_nr_words, ifNull(attrs_boilerpipe_nr_words, 0) AS attrs_boilerpipe_nr_words, ifNull(body_ext_links_number, 0) AS body_ext_links_number, ifNull(body_int_links_number, 0) AS body_int_links_number, ifNull(meta_nofollow, 0) AS meta_nofollow, ifNull(meta_noarchive, 0) AS meta_noarchive, ifNull(props_was_rendered, 0) AS props_was_rendered, ifNull(src_redirect, \'\') AS src_redirect, ifNull(download_time_msec, 0) AS download_time_msec, ifNull(download_ttfb_msec, 0) AS download_ttfb_msec, ifNull(download_size, 0) AS download_size FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.talkspace.com/mental-health/conditions/depression/medications/\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.talkspace.com/mental-health/conditions/depression/medications/\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/","crawl_time":1775789436,"first_indexed_time":1645244859,"http_code":200,"src_unparsed":"com,talkspace!www,\/mental-health\/conditions\/depression\/medications\/ s443","src_root_hash":"16013952968183817603","history_drop_reason":null,"meta_title":"Medications to Treat Depression - Talkspace","meta_descriptions":["Considering medication as a way to treat your depression? Discover and learn about the different types of medications for depression in this guide."],"attrs_boilerpipe_text":"Table of Contents:\nOverview\nTypes of Medications Used to Treat Depression\nMedications Commonly Prescribed for Depression\nHow to Get Depression Medication\nShould You Treat Depression with Medication?\nOur Editorial Standards\nReviewed for Accuracy\nUp-to-date Research\nCredible References\nUpdated On: August 19, 2025\nOverview\nWhile \ndepression\n is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because \ndepression affects the brain\n, some medication for depression has proven beneficial for treatment. The \nAmerican Psychiatric Association\n (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results.\nAntidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too.\nDepression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include:\nIrritability\nFeelings of hopelessness\nInsomnia\nSleeping excessively\nWeight gain or loss\nHaving a short temper or reacting quickly\nPersistent and often uncontrollable thoughts about bad things happening\nAn inability or lack of motivation to take care of yourself\nFeeling unable to carry out your daily responsibilities\nPsychotic symptoms in extreme cases — including hallucinations or delusions\nThoughts of death, \nself harm\n, or suicidal thoughts\nWhen symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as \nsevere depression\n.\nIf you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or \nonline psychiatrist\n. The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more.\nTypes of Medications Used to Treat Depression\nThere are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications.\nSSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression.\nSSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain.\nPopular SSRIs to treat mild or severe depression include:\nCelexa (citalopram)\nLexapro (escitalopram)\nLuvox (fluvoxamine)\nPaxil\/Pexeva\/Brisdelle (paroxetine)\nProzac\/Sarafem (fluoxetine)\nZoloft (sertraline)\nPossible side effects of SSRIs to treat severe or mild depression:\nAgitation\nFeeling shaky or anxious\nIndigestion\nDiarrhea or constipation\nBlurred vision\nLoss of appetite\nWeight loss\nDizziness\nSexual Side Effects\nSNRIs\nSerotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine \nand\n serotonin — SSRIs only work on serotonin levels.\nPopular SNRIs to treat depression include:\nCymbalta (duloxetine)\nEffexor XR (venlafaxine)\nFetzima (levomilnacipran)\nPristiq, Khedezla (desvenlafaxine)\nPossible  side effects of SNRIs to treat depression:\nDry mouth\nNausea\nHeadache\nDizziness\nExcessive sweating\nTCAs\nTricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression.\nPopular TCAs to treat depression include:\nAmitriptyline\nAmoxapine\nAnafranil (clomipramine)\nDoxepin\nNorpramin (desipramine)\nPamelor (nortriptyline)\nProtriptyline\nSurmontil (trimipramine)\nTofranil (imipramine)\nPossible side effects of TCAs to treat depression:\nSlightly blurred vision\nDry mouth\nConstipation\nDizziness\nDrowsiness\nWeight gain\nDifficulty urinating\nExcessive sweating (particularly at night)\nDopamine reuptake blocker\nAnother medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers.\nThere is only 1 dopamine Norepinephrine\n \nreuptake blocker on the market to treat depression:\nAplenzin, Wellbutrin (bupropion)\nPossible side effects of dopamine reuptake blockers to treat depression:\nNausea\nInsomnia\nWeight loss\nHeadache\nConstipation\nAnxiety\nTetracyclic antidepressant\nTetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters.\nThere is only 1 tetracyclic antidepressant on the market to treat depression:\nLudiomil (Maprotiline)\nPossible side effects of Maprotiline to treat depression:\nDrowsiness\nNausea\nNightmares\nWeakness\nTiredness\nSensitivity to sunlight\nDry mouth\nConstipation\nChange in appetite\nWeight change\n5-HT1A receptor antagonist\nAn 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered.\nThere is only 1 5-HT1A receptor antagonist on the market to treat depression:\nViibryd (vilazodone)\nPossible side effects of Viibryd to treat depression:\nNausea\nVomiting\nDifficulty sleeping\n5-HT2 receptor antagonists\n5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression.\nPopular 5-HT2 receptor antagonists to treat depression include:\nNefazodone\nOleptro (trazodone) \nPossible side effects of 5-HT2 receptor antagonists to treat depression:\nHypotension\nDizziness\nHeadache\nFatigue\n5-HT3 receptor antagonist\nThe 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action\nThere is only 1 5-HT3 receptor antagonist on the market to treat depression:\nBrintellix (vortioxetine)\nPossible side effects of 5-HT3 receptor antagonists to treat depression:\nMuscle tension\nHeadache\nMood swings\nDizziness\nSudden angry outbursts\nRunny nose\nMAOIs\nMonoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well.\nPopular MAOIs to treat depression include:\nEmsam (selegiline)\nMarplan (isocarboxazid)\nNardil (phenelzine)\nParnate (tranylcypromine)\nPossible side effects of MAOIs to treat depression:\nNausea\nDry mouth\nDiarrhea or constipation\nDrowsiness\nHeadache\nInsomnia\nDizziness\nLightheadedness\nNoradrenergic antagonist\nPrimarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms.\nThere is only 1 noradrenergic antagonist on the market to treat depression:\nRemeron (mirtazapine)\nPossible side effects of Remeron to treat depression:\nSedation\nHallucinations\nAgitation\nFever\nRapid\/uneven heart rate\nLoss of coordination\nStiff muscles\nConfusion\nFeeling unsteady\nTremors\nFlu-like symptoms\nMedications Commonly Prescribed for Depression\nBecause depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression.\nName Brand\nGeneric\nDescription\nLexapro\nEscitalopram\nAn SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression.\nCelexa\nCitalopram\nSSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression.\nZoloft\nSertraline\nAnother SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain.\nPaxil\nParoxetine\nSSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications.\nProzac\nFluoxetine\nAn antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression.\nCymbalta\nDuloxetine\nAn antidepressant that can treat depression and also treats nerve pain.\nEffexor\nVenlafaxine\nAntidepressant and nerve pain medication that is effective on depression and other anxiety disorders.\nWellbutrin\nBupropion\nWorks in the brain and is used to treat depression; also a smoking cessation treatment.\nDesyrel, Desyrel Dividose, Oleptro, and Trazodone D\nTrazodone\nAntidepressant and sedative.\nRemeron\nMirtazapine\nAntidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works.\nPristiq\nDesvenlafaxine\nTreats major depressive disorder in adults.\nAbilify\nAripiprazole\nAntipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome.\nSeroquel\nQuetiapine\nAnother antipsychotic that treats depression as well as schizophrenia and bipolar disorder.\nZyprexa\nOlanzapine\nAntipsychotic medication that works by helping to restore the balance of natural substances in the brain.\nLithium\n–\nMood stabilizer that can be used to treat mood disorders like depression.\nLamictal\nLamotrigine\nPrescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania.\nTalk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment.\nOnline therapy for depression\nYou don't have to deal with depression alone. Get an appointment from home within a few days.\nHow to Get Depression Medication\nConsidering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression.\nIn order to get medication for depression, the following steps should be taken:\nGet a diagnosis\nTo be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use \nAmerican Psychiatric Association’s\n (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).\nBegin therapy or treatment\nTherapy can help you \nmanage depression\n.\nConsider medication\nMedication can be prescribed in addition to treat your depression.\nTalk to your prescriber\nA psychiatrist can help prescribe you the right medication for depression.\nShould You Treat Depression with Medication?\nDeciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking.\nYour doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering.\nIt’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is \nno \nshame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) \nreports\n that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression.\nWhen you \ntalk to a prescriber or psychiatrist\n, you can ask any of the following.\nQuestions to ask a prescriber:\nShould I consider depression medication?\nYour prescriber can help you weigh the pros and cons of any depression medication that you may be considering.\nWhat are possible side effects of this medication?\nIt’s always important to understand potential \nside effects of any medication\n. This can help you make the best decision for you and your condition and determine whether or not a medication is right for you.\nWhat other treatments should I be considering for my depression?\nMedication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression.\nShould I consider treatment in conjunction with depression medication?\nAny time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying \nonline therapy\n in addition to your medication. A psychiatrist can help you decide.\nAre there any holistic or self-help techniques I can try?\nThere are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression.\nShould I consider therapy in addition to medication?\nCertain forms of talk therapy — like \ncognitive behavioral therapy techniques\n — have proven effective in treating depression.\nAre there any other conditions going on that could be contributing to my depression?\nDepression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines.\n \nIf you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace.\nSee References\nAntidepressant Use Among Adults: United States, 2015-2018\nTorres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021.\nDopamine Reuptake Inhibitors\nScienceDirect. Accessed October 13, 2021.\nAmerican Psychological Association (APA)\nAccessed October 17, 2021.\nAntidepressant use among adults: United States, 2015–2018\nBrody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021.\nDr. Muhammad Munir, MD\nDr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing.","attrs_markdown":"[![Mental Health Conditions](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2024\/04\/Wordmark.svg)](https:\/\/www.talkspace.com\/mental-health\/conditions)\n\n- [Therapy](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Starting therapy](https:\/\/www.talkspace.com\/blog\/category\/starting-therapy\/)\n  - [Therapy types & techniques](https:\/\/www.talkspace.com\/blog\/category\/therapy-types-techniques\/)\n    - [Couples therapy](https:\/\/www.talkspace.com\/blog\/category\/relationships\/)\n    - [Grief therapy](https:\/\/www.talkspace.com\/blog\/category\/grief\/)\n    - [Therapy for teens](https:\/\/www.talkspace.com\/blog\/category\/teens\/)\n  - [All therapy topics](https:\/\/www.talkspace.com\/blog\/category\/therapy\/)\n- [Psychiatry & medications](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Starting psychiatry](https:\/\/www.talkspace.com\/blog\/category\/starting-psychiatry\/)\n  - [All psychiatry articles](https:\/\/www.talkspace.com\/blog\/category\/psychiatry\/)\n  - [Common medications](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Lexapro](https:\/\/www.talkspace.com\/blog\/lexapro\/)\n  - [Cymbalta (Duloxetine)](https:\/\/www.talkspace.com\/blog\/cymbalta\/)\n  - [Zoloft (Sertraline)](https:\/\/www.talkspace.com\/blog\/zoloft\/)\n  - [Lithium](https:\/\/www.talkspace.com\/blog\/lithium\/)\n  - [Propranolol](https:\/\/www.talkspace.com\/blog\/propranolol\/)\n  - [Prozac (Fluoxetine)](https:\/\/www.talkspace.com\/blog\/prozac\/)\n  - [All medications](https:\/\/www.talkspace.com\/blog\/category\/medication\/)\n- [Mental health & wellness](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Relationships](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Dating](https:\/\/www.talkspace.com\/blog\/category\/dating\/)\n  - [Marriage & divorce](https:\/\/www.talkspace.com\/blog\/category\/marriage\/)\n  - [Family](https:\/\/www.talkspace.com\/blog\/category\/family\/)\n  - [Parenting](https:\/\/www.talkspace.com\/blog\/category\/parenting\/)\n  - [Friends](https:\/\/www.talkspace.com\/blog\/category\/friends\/)\n  - [All relationships articles](https:\/\/www.talkspace.com\/blog\/category\/relationships\/)\n  - [Coping](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Stress](https:\/\/www.talkspace.com\/blog\/category\/stress\/)\n  - [Grief](https:\/\/www.talkspace.com\/blog\/category\/grief\/)\n  - [Anger](https:\/\/www.talkspace.com\/blog\/category\/anger\/)\n  - [Trauma & abuse](https:\/\/www.talkspace.com\/blog\/category\/trauma\/)\n  - [Loneliness](https:\/\/www.talkspace.com\/blog\/category\/loneliness\/)\n  - [Bullying](https:\/\/www.talkspace.com\/blog\/category\/bullying\/)\n  - [Sleep & insomnia](https:\/\/www.talkspace.com\/blog\/category\/sleep\/)\n  - [Phobias](https:\/\/www.talkspace.com\/blog\/category\/phobias\/)\n  - [Growth](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/ \"column-3 title\")\n  - [Self esteem](https:\/\/www.talkspace.com\/blog\/category\/self-esteem\/)\n  - [Happiness](https:\/\/www.talkspace.com\/blog\/category\/happiness\/)\n  - [Self care](https:\/\/www.talkspace.com\/blog\/category\/wellness\/)\n  - [Motivation](https:\/\/www.talkspace.com\/blog\/category\/motivation\/)\n  - [Mindfulness](https:\/\/www.talkspace.com\/blog\/category\/mindfulness\/)\n  - [Professional well-being](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [For clinicians](https:\/\/www.talkspace.com\/blog\/category\/for-clinicians\/)\n  - [Career](https:\/\/www.talkspace.com\/blog\/category\/career\/)\n  - [Stress in the workplace](https:\/\/www.talkspace.com\/research\/stress-in-the-workplace)\n  - [Psychology](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Psychology advancements](https:\/\/www.talkspace.com\/blog\/category\/psychology\/)\n  - [Identity & cultural communities](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [LGBTQIA+](https:\/\/www.talkspace.com\/blog\/category\/lgbtq\/)\n  - [Race & identity](https:\/\/www.talkspace.com\/blog\/category\/diverse-communities\/)\n  - [View all articles](https:\/\/www.talkspace.com\/blog\/)\n- [Conditions library](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Conditions](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n  - [Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/)\n  - [Anxiety](https:\/\/www.talkspace.com\/mental-health\/conditions\/generalized-anxiety-disorder\/)\n  - [ADHD](https:\/\/www.talkspace.com\/mental-health\/conditions\/attention-deficit-hyperactivity-disorder\/)\n  - [Bipolar disorder](https:\/\/www.talkspace.com\/mental-health\/conditions\/bipolar-disorder\/)\n  - [OCD](https:\/\/www.talkspace.com\/mental-health\/conditions\/obsessive-compulsive-disorder\/)\n  - [PTSD](https:\/\/www.talkspace.com\/mental-health\/conditions\/post-traumatic-stress-disorder\/)\n  - [Social anxiety](https:\/\/www.talkspace.com\/mental-health\/conditions\/social-anxiety-disorder\/)\n  - [All conditions](https:\/\/www.talkspace.com\/mental-health\/conditions\/#:~:text=V-,A,-Agoraphobia)\n  - [Take an online mental health assessment](https:\/\/www.talkspace.com\/assessments)\n- [Research](https:\/\/www.talkspace.com\/research)\n\n[Find a Therapist](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#leadgen-pop)\n\n![](https:\/\/assets-global.website-files.com\/5f6b627361bad8cad0fc5c99\/6626fd9ba01a1902b1c2bd53_Wordmark-teal.svg)\n\n## Ready to get started?\n## Ready to get started?\nAdd your email to continue\n\nBy submitting your email, you agree to receive reminders and marketing communications.\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif) ![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif) ![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n- [Mental Health Homepage](https:\/\/www.talkspace.com\/)\n- [Conditions Library](https:\/\/www.talkspace.com\/mental-health\/conditions)\n- Medications to Treat Depression\n\n- [Medications to Treat Depression]()\n# Medications to Treat Depression\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-1.svg)\n\n[Overview](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-2.svg)\n\n[Types of Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/types\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-3.svg)\n\n[Symptoms](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/symptoms\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-4.svg)\n\n[Causes](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/causes\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-5.svg)\n\n[Diagnosing](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/diagnosis\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-6.svg)\n\n[Treatment](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/how-to-treat\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-7.svg)\n\n[Therapy](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/therapy-treatment-types\/)\n\n![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-8.svg)\n\n[Medications](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n\n##### Table of Contents:\n- [Overview](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-1)\n- [Types of Medications Used to Treat Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-2)\n- [Medications Commonly Prescribed for Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-3)\n- [How to Get Depression Medication](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-4)\n- [Should You Treat Depression with Medication?](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-5)\n\n## Our Editorial Standards\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-1-1.svg)\n\n##### Reviewed for Accuracy\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-3-1.svg)\n\n##### Up-to-date Research\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-2-1.svg)\n\n##### Credible References\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2022\/02\/munir-headshot.png)\n\nWritten by:[Dr. Muhammad Munir, MD](https:\/\/www.talkspace.com\/mental-health\/conditions\/author\/muhammadmunir\/)\n\nPublished On: November 23, 2021\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/bisma-anwar-headshot.png)\n\nMedically reviewed by: [Bisma Anwar, MA, MSc, LMHC](https:\/\/www.talkspace.com\/mental-health\/conditions\/author\/bisma-anwar\/)\n\nReviewed On: November 23, 2021\n\nUpdated On: August 19, 2025\n\n[![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/Icon-edit.svg)Our Editorial Process](https:\/\/www.talkspace.com\/mental-health\/conditions\/editorial-process\/)   [![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/Icon-tick.svg)Our Review Board](https:\/\/www.talkspace.com\/mental-health\/conditions\/review-board\/%20)\n\n## Overview\nWhile [depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/) is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because [depression affects the brain](https:\/\/www.talkspace.com\/blog\/how-does-depression-affect-the-brain\/), some medication for depression has proven beneficial for treatment. The [American Psychiatric Association](https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression) (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results.\n\nAntidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too.\n\nDepression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include:\n\n- Irritability\n- Feelings of hopelessness\n- Insomnia\n- Sleeping excessively\n- Weight gain or loss\n- Having a short temper or reacting quickly\n- Persistent and often uncontrollable thoughts about bad things happening\n- An inability or lack of motivation to take care of yourself\n- Feeling unable to carry out your daily responsibilities\n- Psychotic symptoms in extreme cases — including hallucinations or delusions\n- Thoughts of death, [self harm](https:\/\/www.talkspace.com\/blog\/self-harm\/), or suicidal thoughts\n\nWhen symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as [severe depression](https:\/\/www.talkspace.com\/blog\/severe-depression-signs-symptoms\/).\n\nIf you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or [online psychiatrist](https:\/\/www.talkspace.com\/psychiatry). The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more.\n\n## Types of Medications Used to Treat Depression\nThere are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications.\n\n### SSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression.\n\nSSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain.\n\n### Popular SSRIs to treat mild or severe depression include:\n- Celexa (citalopram)\n- [Lexapro (escitalopram)](https:\/\/www.talkspace.com\/psychiatry\/medications\/lexapro\/)\n- Luvox (fluvoxamine)\n- Paxil\/Pexeva\/Brisdelle (paroxetine)\n- [Prozac\/Sarafem (fluoxetine)](https:\/\/www.talkspace.com\/psychiatry\/medications\/prozac\/)\n- [Zoloft (sertraline)](https:\/\/www.talkspace.com\/psychiatry\/medications\/zoloft\/)\n#### Possible side effects of SSRIs to treat severe or mild depression:\n- Agitation\n- Feeling shaky or anxious\n- Indigestion\n- Diarrhea or constipation\n- Blurred vision\n- Loss of appetite\n- Weight loss\n- Dizziness\n- Sexual Side Effects\n### SNRIs\nSerotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine *and* serotonin — SSRIs only work on serotonin levels.\n\n### Popular SNRIs to treat depression include:\n- [Cymbalta (duloxetine)](https:\/\/www.talkspace.com\/psychiatry\/medications\/cymbalta\/)\n- Effexor XR (venlafaxine)\n- Fetzima (levomilnacipran)\n- Pristiq, Khedezla (desvenlafaxine)\n#### Possible side effects of SNRIs to treat depression:\n- Dry mouth\n- Nausea\n- Headache\n- Dizziness\n- Excessive sweating\n### TCAs\nTricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression.\n\n### Popular TCAs to treat depression include:\n- Amitriptyline\n- Amoxapine\n- Anafranil (clomipramine)\n- Doxepin\n- Norpramin (desipramine)\n- Pamelor (nortriptyline)\n- Protriptyline\n- Surmontil (trimipramine)\n- Tofranil (imipramine)\n#### Possible side effects of TCAs to treat depression:\n- Slightly blurred vision\n- Dry mouth\n- Constipation\n- Dizziness\n- Drowsiness\n- Weight gain\n- Difficulty urinating\n- Excessive sweating (particularly at night)\n### Dopamine reuptake blocker\nAnother medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers.\n\n**There is only 1 dopamine Norepinephrine** **reuptake blocker on the market to treat depression:**\n\n- Aplenzin, Wellbutrin (bupropion)\n#### Possible side effects of dopamine reuptake blockers to treat depression:\n- Nausea\n- Insomnia\n- Weight loss\n- Headache\n- Constipation\n- Anxiety\n### Tetracyclic antidepressant\nTetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters.\n\n**There is only 1 tetracyclic antidepressant on the market to treat depression:**\n\n- Ludiomil (Maprotiline)\n#### Possible side effects of Maprotiline to treat depression:\n- Drowsiness\n- Nausea\n- Nightmares\n- Weakness\n- Tiredness\n- Sensitivity to sunlight\n- Dry mouth\n- Constipation\n- Change in appetite\n- Weight change\n### 5-HT1A receptor antagonist\nAn 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered.\n\n**There is only 1 5-HT1A receptor antagonist on the market to treat depression:**\n\n- Viibryd (vilazodone)\n#### Possible side effects of Viibryd to treat depression:\n- Nausea\n- Vomiting\n- Difficulty sleeping\n### 5-HT2 receptor antagonists\n5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression.\n\n**Popular 5-HT2 receptor antagonists to treat depression include:**\n\n- Nefazodone\n- [Oleptro (trazodone)](https:\/\/www.talkspace.com\/psychiatry\/medications\/trazodone\/)\n#### Possible side effects of 5-HT2 receptor antagonists to treat depression:\n- Hypotension\n- Dizziness\n- Headache\n- Fatigue\n### 5-HT3 receptor antagonist\nThe 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action\n\n**There is only 1 5-HT3 receptor antagonist on the market to treat depression:**\n\n- Brintellix (vortioxetine)\n#### Possible side effects of 5-HT3 receptor antagonists to treat depression:\n- Muscle tension\n- Headache\n- Mood swings\n- Dizziness\n- Sudden angry outbursts\n- Runny nose\n### MAOIs\nMonoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well.\n\n### Popular MAOIs to treat depression include:\n- Emsam (selegiline)\n- Marplan (isocarboxazid)\n- Nardil (phenelzine)\n- Parnate (tranylcypromine)\n#### Possible side effects of MAOIs to treat depression:\n- Nausea\n- Dry mouth\n- Diarrhea or constipation\n- Drowsiness\n- Headache\n- Insomnia\n- Dizziness\n- Lightheadedness\n### Noradrenergic antagonist\nPrimarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms.\n\n**There is only 1 noradrenergic antagonist on the market to treat depression:**\n\n- Remeron (mirtazapine)\n#### Possible side effects of Remeron to treat depression:\n- Sedation\n- Hallucinations\n- Agitation\n- Fever\n- Rapid\/uneven heart rate\n- Loss of coordination\n- Stiff muscles\n- Confusion\n- Feeling unsteady\n- Tremors\n- Flu-like symptoms\n\n## Medications Commonly Prescribed for Depression\nBecause depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression.\n\n|   |   |   |\n|---|---|---|\n| **Name Brand** | **Generic** | **Description** |\n| Lexapro | Escitalopram | An SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression. |\n| Celexa | Citalopram | SSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression. |\n| Zoloft | Sertraline | Another SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain. |\n| Paxil | Paroxetine | SSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications. |\n| Prozac | Fluoxetine | An antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression. |\n| Cymbalta | Duloxetine | An antidepressant that can treat depression and also treats nerve pain. |\n| Effexor | Venlafaxine | Antidepressant and nerve pain medication that is effective on depression and other anxiety disorders. |\n| Wellbutrin | Bupropion | Works in the brain and is used to treat depression; also a smoking cessation treatment. |\n| Desyrel, Desyrel Dividose, Oleptro, and Trazodone D | Trazodone | Antidepressant and sedative. |\n| Remeron | Mirtazapine | Antidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works. |\n| Pristiq | Desvenlafaxine | Treats major depressive disorder in adults. |\n| Abilify | Aripiprazole | Antipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome. |\n| Seroquel | Quetiapine | Another antipsychotic that treats depression as well as schizophrenia and bipolar disorder. |\n| Zyprexa | Olanzapine | Antipsychotic medication that works by helping to restore the balance of natural substances in the brain. |\n| Lithium | – | Mood stabilizer that can be used to treat mood disorders like depression. |\n| Lamictal | Lamotrigine | Prescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania. |\n\nTalk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment.\n\n### Online therapy for depression\nYou don't have to deal with depression alone. Get an appointment from home within a few days.\n\n[Get started](https:\/\/www.talkspace.com\/treatment\/depression)\n\n## How to Get Depression Medication\nConsidering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression.\n\nIn order to get medication for depression, the following steps should be taken:\n\n1. **Get a diagnosis**To be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use [American Psychiatric Association’s](https:\/\/www.apa.org\/) (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).\n2. **Begin therapy or treatment**Therapy can help you [manage depression](https:\/\/www.talkspace.com\/blog\/dealing-depression-need-know\/).\n3. **Consider medication**  \n    Medication can be prescribed in addition to treat your depression.\n4. **Talk to your prescriber**A psychiatrist can help prescribe you the right medication for depression.\n\n## Should You Treat Depression with Medication?\nDeciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking.\n\nYour doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering.\n\nIt’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is *no* shame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) [reports](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm) that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression.\n\nWhen you [talk to a prescriber or psychiatrist](https:\/\/www.talkspace.com\/blog\/tips-for-talking-with-a-psychiatrist-for-the-first-time\/), you can ask any of the following.\n\n### Questions to ask a prescriber:\n- **Should I consider depression medication?**  \n   Your prescriber can help you weigh the pros and cons of any depression medication that you may be considering.\n- **What are possible side effects of this medication?** It’s always important to understand potential [side effects of any medication](https:\/\/www.talkspace.com\/blog\/side-effects-medication-drugs\/). This can help you make the best decision for you and your condition and determine whether or not a medication is right for you.\n- **What other treatments should I be considering for my depression?** Medication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression.\n- **Should I consider treatment in conjunction with depression medication?** Any time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying [online therapy](https:\/\/www.talkspace.com\/online-therapy\/) in addition to your medication. A psychiatrist can help you decide.\n- **Are there any holistic or self-help techniques I can try?** There are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression.\n- **Should I consider therapy in addition to medication?** Certain forms of talk therapy — like [cognitive behavioral therapy techniques](https:\/\/www.talkspace.com\/blog\/cbt-techniques\/) — have proven effective in treating depression.\n- **Are there any other conditions going on that could be contributing to my depression?** Depression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines.\n\nIf you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace.\n\n### See References\n- ##### [Antidepressant Use Among Adults: United States, 2015-2018](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm)\n  Torres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021.\n- ##### [Dopamine Reuptake Inhibitors](https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/dopamine-reuptake-inhibitor)\n  ScienceDirect. Accessed October 13, 2021.\n- ##### [American Psychological Association (APA)](https:\/\/www.apa.org\/)\n  Accessed October 17, 2021.\n- ##### [Antidepressant use among adults: United States, 2015–2018](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm#Suggested_citation)\n  Brody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021.\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2022\/02\/munir-headshot.png)\n\n[Dr. Muhammad Munir, MD](https:\/\/www.talkspace.com\/mental-health\/conditions\/author\/muhammadmunir\/)\n\nDr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing.\n\n[![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/Icon-edit.svg)Our Editorial Process](https:\/\/www.talkspace.com\/mental-health\/conditions\/editorial-process\/)   [![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/Icon-tick.svg)Our Review Board](https:\/\/www.talkspace.com\/mental-health\/conditions\/review-board\/%20)\n\n[![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-share.svg) Share]()   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Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  January 15, 2026\n\n#### [Understanding Depression in Veterans](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/depression-in-veterans\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  January 6, 2026\n\n#### [Medications for Seasonal Affective Disorder](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/seasonal-affective-disorder-medication\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  January 6, 2026\n\n#### [How To Help Someone With Seasonal Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/how-to-help-someone-with-seasonal-depression\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  June 3, 2025\n\n#### [How Long Does Therapy Take to Work for Depression?](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/how-long-does-therapy-take-for-depression\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  June 3, 2025\n\n#### [How to Tell the Difference Between Depression and Laziness](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/depression-vs-laziness\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  May 5, 2025\n\n#### [How To Be a Good Mom When You’re Depressed](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/how-to-be-a-good-mom-when-depressed\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  February 21, 2025\n\n#### [Navigating Depression After Retirement](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/retirement-depression\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  January 17, 2025\n\n#### [What to Do When Your Parent is Struggling with Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/what-to-do-when-your-parent-is-depressed\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  October 23, 2024\n\n#### [Depression in Nurses: A Mental Health Crisis in Healthcare](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/depression-in-nurses\/)\n\n![Featured Image](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n**Depression**  October 23, 2024\n\n#### [Fatherhood Depression: Breaking the Silence on Depressed Dads](https:\/\/www.talkspace.com\/mental-health\/conditions\/articles\/fatherhood-depression\/)\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)\n\n### Learn more about Depression\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-2.svg)\n  ##### [Types of Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/types\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-3.svg)\n  ##### [Symptoms of Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/symptoms\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-4.svg)\n  ##### [Causes of Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/causes\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-5.svg)\n  ##### [Diagnosing of Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/diagnosis\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-6.svg)\n  ##### [Treatment for Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/how-to-treat\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-7.svg)\n  ##### [Therapy for Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/therapy-treatment-types\/)\n- ![Icon](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/icon-8.svg)\n  ##### [Medications for Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n\n## Effective and affordable mental health treatment\n[Get Started](https:\/\/match.talkspace.com\/flow\/90\/step\/1)\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/Employers-phones-2.png)\n\n- ![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2020\/12\/aicpa-soc2.png)\n- 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[![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2020\/12\/social-linkedin.svg)](https:\/\/www.linkedin.com\/company\/talkspace-online-therapy)\n\n##### Talkspace\n2578 Broadway \\#607  \n New York, NY 10025\n\n#### Services\n- [Online therapy](https:\/\/www.talkspace.com\/online-therapy\/)\n- [Couples therapy](https:\/\/www.talkspace.com\/online-therapy\/couples-therapy\/)\n- [Psychiatry](https:\/\/www.talkspace.com\/psychiatry)\n- [Teen therapy](https:\/\/try.talkspace.com\/talkspace-for-teens)\n- [LGBTQIA+ community](https:\/\/www.talkspace.com\/online-therapy\/lgbtqia)\n- [Therapy for veterans](https:\/\/www.talkspace.com\/online-therapy\/veterans)\n- [Unlimited messaging therapy](https:\/\/www.talkspace.com\/online-therapy\/unlimited-messaging-therapy\/)\n- [Talkspace for business](https:\/\/business.talkspace.com\/)\n- [Lasting from Talkspace](https:\/\/getlasting.com\/)\n- [Talkspace Self-Guided app](https:\/\/www.talkspace.com\/self-guided-therapy)\n\n#### Useful Links\n- [Find a therapist](https:\/\/www.talkspace.com\/therapists)\n- [Mental health library](https:\/\/www.talkspace.com\/mental-health\/conditions\/)\n- [Free mental health tests](https:\/\/www.talkspace.com\/assessments)\n- [Anxiety test](https:\/\/www.talkspace.com\/assessments\/anxiety-test)\n- [Depression test](https:\/\/www.talkspace.com\/assessments\/depression-test)\n- [Talkspace reviews](https:\/\/www.talkspace.com\/reviews)\n- [Insurance coverage](https:\/\/www.talkspace.com\/coverage\/insurance)\n\n#### About\n- [Blog](https:\/\/www.talkspace.com\/blog\/)\n- [Careers](https:\/\/www.talkspace.com\/careers)\n- [Join our network](https:\/\/www.talkspace.com\/join-our-network)\n- [Press](https:\/\/www.talkspace.com\/press\/)\n- [Research](https:\/\/www.talkspace.com\/research)\n- [Investors](https:\/\/investors.talkspace.com\/investor-relations\/)\n- [Privacy policy](https:\/\/www.talkspace.com\/public\/privacy-policy)\n- [Privacy settings](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/)\n- [Terms of use](https:\/\/www.talkspace.com\/public\/terms)\n- [Accessibility](https:\/\/www.talkspace.com\/accessibility-statement)\n- [Customer support](https:\/\/help.talkspace.com\/hc\/en-us)\n- [Emergency resources](https:\/\/helpnow.talkspace.com\/)\n\nIf you are in a life threatening situation – don’t use this site. Call 988 or use [these resources](https:\/\/helpnow.talkspace.com\/) to get immediate help.\n\n[**Therapy may be free for you**](https:\/\/www.talkspace.com\/online-therapy\/?cta_source=conditions_promo_bar)","attrs_readable_markdown":"##### Table of Contents:\n- [Overview](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-1)\n- [Types of Medications Used to Treat Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-2)\n- [Medications Commonly Prescribed for Depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-3)\n- [How to Get Depression Medication](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-4)\n- [Should You Treat Depression with Medication?](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/medications\/#section-5)\n\n## Our Editorial Standards\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-1-1.svg)\n\nReviewed for Accuracy\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-3-1.svg)\n\nUp-to-date Research\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2023\/04\/editorial-Icon-2-1.svg)\n\nCredible References\n\nUpdated On: August 19, 2025\n\n## Overview\nWhile [depression](https:\/\/www.talkspace.com\/mental-health\/conditions\/depression\/) is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because [depression affects the brain](https:\/\/www.talkspace.com\/blog\/how-does-depression-affect-the-brain\/), some medication for depression has proven beneficial for treatment. The [American Psychiatric Association](https:\/\/www.psychiatry.org\/patients-families\/depression\/what-is-depression) (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results.\n\nAntidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too.\n\nDepression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include:\n\n- Irritability\n- Feelings of hopelessness\n- Insomnia\n- Sleeping excessively\n- Weight gain or loss\n- Having a short temper or reacting quickly\n- Persistent and often uncontrollable thoughts about bad things happening\n- An inability or lack of motivation to take care of yourself\n- Feeling unable to carry out your daily responsibilities\n- Psychotic symptoms in extreme cases — including hallucinations or delusions\n- Thoughts of death, [self harm](https:\/\/www.talkspace.com\/blog\/self-harm\/), or suicidal thoughts\n\nWhen symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as [severe depression](https:\/\/www.talkspace.com\/blog\/severe-depression-signs-symptoms\/).\n\nIf you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or [online psychiatrist](https:\/\/www.talkspace.com\/psychiatry). The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more.\n\n## Types of Medications Used to Treat Depression\nThere are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications.\n\n### SSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression.\n\nSSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain.\n\n### Popular SSRIs to treat mild or severe depression include:\n- Celexa (citalopram)\n- [Lexapro (escitalopram)](https:\/\/www.talkspace.com\/psychiatry\/medications\/lexapro\/)\n- Luvox (fluvoxamine)\n- Paxil\/Pexeva\/Brisdelle (paroxetine)\n- [Prozac\/Sarafem (fluoxetine)](https:\/\/www.talkspace.com\/psychiatry\/medications\/prozac\/)\n- [Zoloft (sertraline)](https:\/\/www.talkspace.com\/psychiatry\/medications\/zoloft\/)\n#### Possible side effects of SSRIs to treat severe or mild depression:\n- Agitation\n- Feeling shaky or anxious\n- Indigestion\n- Diarrhea or constipation\n- Blurred vision\n- Loss of appetite\n- Weight loss\n- Dizziness\n- Sexual Side Effects\n### SNRIs\nSerotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine *and* serotonin — SSRIs only work on serotonin levels.\n\n### Popular SNRIs to treat depression include:\n- [Cymbalta (duloxetine)](https:\/\/www.talkspace.com\/psychiatry\/medications\/cymbalta\/)\n- Effexor XR (venlafaxine)\n- Fetzima (levomilnacipran)\n- Pristiq, Khedezla (desvenlafaxine)\n#### Possible side effects of SNRIs to treat depression:\n- Dry mouth\n- Nausea\n- Headache\n- Dizziness\n- Excessive sweating\n### TCAs\nTricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression.\n\n### Popular TCAs to treat depression include:\n- Amitriptyline\n- Amoxapine\n- Anafranil (clomipramine)\n- Doxepin\n- Norpramin (desipramine)\n- Pamelor (nortriptyline)\n- Protriptyline\n- Surmontil (trimipramine)\n- Tofranil (imipramine)\n#### Possible side effects of TCAs to treat depression:\n- Slightly blurred vision\n- Dry mouth\n- Constipation\n- Dizziness\n- Drowsiness\n- Weight gain\n- Difficulty urinating\n- Excessive sweating (particularly at night)\n### Dopamine reuptake blocker\nAnother medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers.\n\n**There is only 1 dopamine Norepinephrine** **reuptake blocker on the market to treat depression:**\n\n- Aplenzin, Wellbutrin (bupropion)\n#### Possible side effects of dopamine reuptake blockers to treat depression:\n- Nausea\n- Insomnia\n- Weight loss\n- Headache\n- Constipation\n- Anxiety\n### Tetracyclic antidepressant\nTetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters.\n\n**There is only 1 tetracyclic antidepressant on the market to treat depression:**\n\n- Ludiomil (Maprotiline)\n#### Possible side effects of Maprotiline to treat depression:\n- Drowsiness\n- Nausea\n- Nightmares\n- Weakness\n- Tiredness\n- Sensitivity to sunlight\n- Dry mouth\n- Constipation\n- Change in appetite\n- Weight change\n### 5-HT1A receptor antagonist\nAn 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered.\n\n**There is only 1 5-HT1A receptor antagonist on the market to treat depression:**\n\n- Viibryd (vilazodone)\n#### Possible side effects of Viibryd to treat depression:\n- Nausea\n- Vomiting\n- Difficulty sleeping\n### 5-HT2 receptor antagonists\n5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression.\n\n**Popular 5-HT2 receptor antagonists to treat depression include:**\n\n- Nefazodone\n- [Oleptro (trazodone)](https:\/\/www.talkspace.com\/psychiatry\/medications\/trazodone\/)\n#### Possible side effects of 5-HT2 receptor antagonists to treat depression:\n- Hypotension\n- Dizziness\n- Headache\n- Fatigue\n### 5-HT3 receptor antagonist\nThe 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action\n\n**There is only 1 5-HT3 receptor antagonist on the market to treat depression:**\n\n- Brintellix (vortioxetine)\n#### Possible side effects of 5-HT3 receptor antagonists to treat depression:\n- Muscle tension\n- Headache\n- Mood swings\n- Dizziness\n- Sudden angry outbursts\n- Runny nose\n### MAOIs\nMonoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well.\n\n### Popular MAOIs to treat depression include:\n- Emsam (selegiline)\n- Marplan (isocarboxazid)\n- Nardil (phenelzine)\n- Parnate (tranylcypromine)\n#### Possible side effects of MAOIs to treat depression:\n- Nausea\n- Dry mouth\n- Diarrhea or constipation\n- Drowsiness\n- Headache\n- Insomnia\n- Dizziness\n- Lightheadedness\n### Noradrenergic antagonist\nPrimarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms.\n\n**There is only 1 noradrenergic antagonist on the market to treat depression:**\n\n- Remeron (mirtazapine)\n#### Possible side effects of Remeron to treat depression:\n- Sedation\n- Hallucinations\n- Agitation\n- Fever\n- Rapid\/uneven heart rate\n- Loss of coordination\n- Stiff muscles\n- Confusion\n- Feeling unsteady\n- Tremors\n- Flu-like symptoms\n\n## Medications Commonly Prescribed for Depression\nBecause depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression.\n\n|   |   |   |\n|---|---|---|\n| **Name Brand** | **Generic** | **Description** |\n| Lexapro | Escitalopram | An SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression. |\n| Celexa | Citalopram | SSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression. |\n| Zoloft | Sertraline | Another SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain. |\n| Paxil | Paroxetine | SSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications. |\n| Prozac | Fluoxetine | An antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression. |\n| Cymbalta | Duloxetine | An antidepressant that can treat depression and also treats nerve pain. |\n| Effexor | Venlafaxine | Antidepressant and nerve pain medication that is effective on depression and other anxiety disorders. |\n| Wellbutrin | Bupropion | Works in the brain and is used to treat depression; also a smoking cessation treatment. |\n| Desyrel, Desyrel Dividose, Oleptro, and Trazodone D | Trazodone | Antidepressant and sedative. |\n| Remeron | Mirtazapine | Antidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works. |\n| Pristiq | Desvenlafaxine | Treats major depressive disorder in adults. |\n| Abilify | Aripiprazole | Antipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome. |\n| Seroquel | Quetiapine | Another antipsychotic that treats depression as well as schizophrenia and bipolar disorder. |\n| Zyprexa | Olanzapine | Antipsychotic medication that works by helping to restore the balance of natural substances in the brain. |\n| Lithium | – | Mood stabilizer that can be used to treat mood disorders like depression. |\n| Lamictal | Lamotrigine | Prescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania. |\n\nTalk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment.\n\n### Online therapy for depression\nYou don't have to deal with depression alone. Get an appointment from home within a few days.\n\n## How to Get Depression Medication\nConsidering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression.\n\nIn order to get medication for depression, the following steps should be taken:\n\n1. **Get a diagnosis**To be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use [American Psychiatric Association’s](https:\/\/www.apa.org\/) (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).\n2. **Begin therapy or treatment**Therapy can help you [manage depression](https:\/\/www.talkspace.com\/blog\/dealing-depression-need-know\/).\n3. **Consider medication**  \n    Medication can be prescribed in addition to treat your depression.\n4. **Talk to your prescriber**A psychiatrist can help prescribe you the right medication for depression.\n\n## Should You Treat Depression with Medication?\nDeciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking.\n\nYour doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering.\n\nIt’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is *no* shame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) [reports](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm) that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression.\n\nWhen you [talk to a prescriber or psychiatrist](https:\/\/www.talkspace.com\/blog\/tips-for-talking-with-a-psychiatrist-for-the-first-time\/), you can ask any of the following.\n\n### Questions to ask a prescriber:\n- **Should I consider depression medication?**  \n   Your prescriber can help you weigh the pros and cons of any depression medication that you may be considering.\n- **What are possible side effects of this medication?** It’s always important to understand potential [side effects of any medication](https:\/\/www.talkspace.com\/blog\/side-effects-medication-drugs\/). This can help you make the best decision for you and your condition and determine whether or not a medication is right for you.\n- **What other treatments should I be considering for my depression?** Medication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression.\n- **Should I consider treatment in conjunction with depression medication?** Any time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying [online therapy](https:\/\/www.talkspace.com\/online-therapy\/) in addition to your medication. A psychiatrist can help you decide.\n- **Are there any holistic or self-help techniques I can try?** There are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression.\n- **Should I consider therapy in addition to medication?** Certain forms of talk therapy — like [cognitive behavioral therapy techniques](https:\/\/www.talkspace.com\/blog\/cbt-techniques\/) — have proven effective in treating depression.\n- **Are there any other conditions going on that could be contributing to my depression?** Depression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines.\n\nIf you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace.\n\n### See References\n- ##### [Antidepressant Use Among Adults: United States, 2015-2018](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm)\n  Torres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021.\n- ##### [Dopamine Reuptake Inhibitors](https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/dopamine-reuptake-inhibitor)\n  ScienceDirect. Accessed October 13, 2021.\n- ##### [American Psychological Association (APA)](https:\/\/www.apa.org\/)\n  Accessed October 17, 2021.\n- ##### [Antidepressant use among adults: United States, 2015–2018](https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm#Suggested_citation)\n  Brody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021.\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/uploads\/sites\/2\/2022\/02\/munir-headshot.png)\n\n[Dr. Muhammad Munir, MD](https:\/\/www.talkspace.com\/mental-health\/conditions\/author\/muhammadmunir\/)\n\nDr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing.\n\n![](https:\/\/www.talkspace.com\/mental-health\/conditions\/wp-content\/themes\/talkspace-conditions\/assets\/images\/0.gif)","meta_canonical":null,"ml_categories_json":"{\"\/Health\":998,\"\/Health\/Mental_Health\":975,\"\/Health\/Mental_Health\/Depression\":973}","ml_types_json":"{\"\/Article\":998,\"\/Article\/Tutorial_or_Guide\":972}","ml_intent_types_json":"{\"Informational\":997,\"Commercial\":116}","meta_language":"en-us","attrs_author":null,"attrs_publish_time":1755607132,"attrs_original_publish_time":1645244859,"attrs_is_republished":1,"attrs_nr_words":"2804","attrs_boilerpipe_nr_words":"2314","body_ext_links_number":12,"body_int_links_number":124,"meta_nofollow":0,"meta_noarchive":0,"props_was_rendered":0,"src_redirect":"","download_time_msec":249,"download_ttfb_msec":248,"download_size":30863}

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Medications to Treat Depression - Talkspace

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Considering medication as a way to treat your depression? Discover and learn about the different types of medications for depression in this guide.

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Table of Contents: Overview Types of Medications Used to Treat Depression Medications Commonly Prescribed for Depression How to Get Depression Medication Should You Treat Depression with Medication? Our Editorial Standards Reviewed for Accuracy Up-to-date Research Credible References Updated On: August 19, 2025 Overview While depression is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because depression affects the brain , some medication for depression has proven beneficial for treatment. The American Psychiatric Association (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results. Antidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too. Depression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include: Irritability Feelings of hopelessness Insomnia Sleeping excessively Weight gain or loss Having a short temper or reacting quickly Persistent and often uncontrollable thoughts about bad things happening An inability or lack of motivation to take care of yourself Feeling unable to carry out your daily responsibilities Psychotic symptoms in extreme cases — including hallucinations or delusions Thoughts of death, self harm , or suicidal thoughts When symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as severe depression . If you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or online psychiatrist . The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more. Types of Medications Used to Treat Depression There are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications. SSRIs Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression. SSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain. Popular SSRIs to treat mild or severe depression include: Celexa (citalopram) Lexapro (escitalopram) Luvox (fluvoxamine) Paxil/Pexeva/Brisdelle (paroxetine) Prozac/Sarafem (fluoxetine) Zoloft (sertraline) Possible side effects of SSRIs to treat severe or mild depression: Agitation Feeling shaky or anxious Indigestion Diarrhea or constipation Blurred vision Loss of appetite Weight loss Dizziness Sexual Side Effects SNRIs Serotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine and serotonin — SSRIs only work on serotonin levels. Popular SNRIs to treat depression include: Cymbalta (duloxetine) Effexor XR (venlafaxine) Fetzima (levomilnacipran) Pristiq, Khedezla (desvenlafaxine) Possible side effects of SNRIs to treat depression: Dry mouth Nausea Headache Dizziness Excessive sweating TCAs Tricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression. Popular TCAs to treat depression include: Amitriptyline Amoxapine Anafranil (clomipramine) Doxepin Norpramin (desipramine) Pamelor (nortriptyline) Protriptyline Surmontil (trimipramine) Tofranil (imipramine) Possible side effects of TCAs to treat depression: Slightly blurred vision Dry mouth Constipation Dizziness Drowsiness Weight gain Difficulty urinating Excessive sweating (particularly at night) Dopamine reuptake blocker Another medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers. There is only 1 dopamine Norepinephrine reuptake blocker on the market to treat depression: Aplenzin, Wellbutrin (bupropion) Possible side effects of dopamine reuptake blockers to treat depression: Nausea Insomnia Weight loss Headache Constipation Anxiety Tetracyclic antidepressant Tetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters. There is only 1 tetracyclic antidepressant on the market to treat depression: Ludiomil (Maprotiline) Possible side effects of Maprotiline to treat depression: Drowsiness Nausea Nightmares Weakness Tiredness Sensitivity to sunlight Dry mouth Constipation Change in appetite Weight change 5-HT1A receptor antagonist An 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered. There is only 1 5-HT1A receptor antagonist on the market to treat depression: Viibryd (vilazodone) Possible side effects of Viibryd to treat depression: Nausea Vomiting Difficulty sleeping 5-HT2 receptor antagonists 5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression. Popular 5-HT2 receptor antagonists to treat depression include: Nefazodone Oleptro (trazodone) Possible side effects of 5-HT2 receptor antagonists to treat depression: Hypotension Dizziness Headache Fatigue 5-HT3 receptor antagonist The 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action There is only 1 5-HT3 receptor antagonist on the market to treat depression: Brintellix (vortioxetine) Possible side effects of 5-HT3 receptor antagonists to treat depression: Muscle tension Headache Mood swings Dizziness Sudden angry outbursts Runny nose MAOIs Monoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well. Popular MAOIs to treat depression include: Emsam (selegiline) Marplan (isocarboxazid) Nardil (phenelzine) Parnate (tranylcypromine) Possible side effects of MAOIs to treat depression: Nausea Dry mouth Diarrhea or constipation Drowsiness Headache Insomnia Dizziness Lightheadedness Noradrenergic antagonist Primarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms. There is only 1 noradrenergic antagonist on the market to treat depression: Remeron (mirtazapine) Possible side effects of Remeron to treat depression: Sedation Hallucinations Agitation Fever Rapid/uneven heart rate Loss of coordination Stiff muscles Confusion Feeling unsteady Tremors Flu-like symptoms Medications Commonly Prescribed for Depression Because depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression. Name Brand Generic Description Lexapro Escitalopram An SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression. Celexa Citalopram SSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression. Zoloft Sertraline Another SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain. Paxil Paroxetine SSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications. Prozac Fluoxetine An antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression. Cymbalta Duloxetine An antidepressant that can treat depression and also treats nerve pain. Effexor Venlafaxine Antidepressant and nerve pain medication that is effective on depression and other anxiety disorders. Wellbutrin Bupropion Works in the brain and is used to treat depression; also a smoking cessation treatment. Desyrel, Desyrel Dividose, Oleptro, and Trazodone D Trazodone Antidepressant and sedative. Remeron Mirtazapine Antidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works. Pristiq Desvenlafaxine Treats major depressive disorder in adults. Abilify Aripiprazole Antipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome. Seroquel Quetiapine Another antipsychotic that treats depression as well as schizophrenia and bipolar disorder. Zyprexa Olanzapine Antipsychotic medication that works by helping to restore the balance of natural substances in the brain. Lithium – Mood stabilizer that can be used to treat mood disorders like depression. Lamictal Lamotrigine Prescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania. Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. Online therapy for depression You don't have to deal with depression alone. Get an appointment from home within a few days. How to Get Depression Medication Considering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression. In order to get medication for depression, the following steps should be taken: Get a diagnosis To be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use American Psychiatric Association’s (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Begin therapy or treatment Therapy can help you manage depression . Consider medication Medication can be prescribed in addition to treat your depression. Talk to your prescriber A psychiatrist can help prescribe you the right medication for depression. Should You Treat Depression with Medication? Deciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking. Your doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering. It’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is no shame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) reports that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression. When you talk to a prescriber or psychiatrist , you can ask any of the following. Questions to ask a prescriber: Should I consider depression medication? Your prescriber can help you weigh the pros and cons of any depression medication that you may be considering. What are possible side effects of this medication? It’s always important to understand potential side effects of any medication . This can help you make the best decision for you and your condition and determine whether or not a medication is right for you. What other treatments should I be considering for my depression? Medication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression. Should I consider treatment in conjunction with depression medication? Any time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying online therapy in addition to your medication. A psychiatrist can help you decide. Are there any holistic or self-help techniques I can try? There are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression. Should I consider therapy in addition to medication? Certain forms of talk therapy — like cognitive behavioral therapy techniques — have proven effective in treating depression. Are there any other conditions going on that could be contributing to my depression? Depression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines. If you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace. See References Antidepressant Use Among Adults: United States, 2015-2018 Torres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021. Dopamine Reuptake Inhibitors ScienceDirect. Accessed October 13, 2021. American Psychological Association (APA) Accessed October 17, 2021. Antidepressant use among adults: United States, 2015–2018 Brody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021. Dr. Muhammad Munir, MD Dr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing.

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Add your email to continue By submitting your email, you agree to receive reminders and marketing communications. ![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif) ![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif) ![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif) - [Mental Health Homepage](https://www.talkspace.com/) - [Conditions Library](https://www.talkspace.com/mental-health/conditions) - Medications to Treat Depression - [Medications to Treat Depression]() # Medications to Treat Depression ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-1.svg) [Overview](https://www.talkspace.com/mental-health/conditions/depression/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-2.svg) [Types of Depression](https://www.talkspace.com/mental-health/conditions/depression/types/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-3.svg) [Symptoms](https://www.talkspace.com/mental-health/conditions/depression/symptoms/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-4.svg) [Causes](https://www.talkspace.com/mental-health/conditions/depression/causes/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-5.svg) [Diagnosing](https://www.talkspace.com/mental-health/conditions/depression/diagnosis/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-6.svg) [Treatment](https://www.talkspace.com/mental-health/conditions/depression/how-to-treat/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-7.svg) [Therapy](https://www.talkspace.com/mental-health/conditions/depression/therapy-treatment-types/) ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-8.svg) [Medications](https://www.talkspace.com/mental-health/conditions/depression/medications/) ##### Table of Contents: - [Overview](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-1) - [Types of Medications Used to Treat Depression](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-2) - [Medications Commonly Prescribed for Depression](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-3) - [How to Get Depression Medication](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-4) - [Should You Treat Depression with Medication?](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-5) ## Our Editorial Standards ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-1-1.svg) ##### Reviewed for Accuracy ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-3-1.svg) ##### Up-to-date Research ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-2-1.svg) ##### Credible References ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2022/02/munir-headshot.png) Written by:[Dr. Muhammad Munir, MD](https://www.talkspace.com/mental-health/conditions/author/muhammadmunir/) Published On: November 23, 2021 ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/bisma-anwar-headshot.png) Medically reviewed by: [Bisma Anwar, MA, MSc, LMHC](https://www.talkspace.com/mental-health/conditions/author/bisma-anwar/) Reviewed On: November 23, 2021 Updated On: August 19, 2025 [![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/Icon-edit.svg)Our Editorial Process](https://www.talkspace.com/mental-health/conditions/editorial-process/) [![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/Icon-tick.svg)Our Review Board](https://www.talkspace.com/mental-health/conditions/review-board/%20) ## Overview While [depression](https://www.talkspace.com/mental-health/conditions/depression/) is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because [depression affects the brain](https://www.talkspace.com/blog/how-does-depression-affect-the-brain/), some medication for depression has proven beneficial for treatment. The [American Psychiatric Association](https://www.psychiatry.org/patients-families/depression/what-is-depression) (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results. Antidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too. Depression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include: - Irritability - Feelings of hopelessness - Insomnia - Sleeping excessively - Weight gain or loss - Having a short temper or reacting quickly - Persistent and often uncontrollable thoughts about bad things happening - An inability or lack of motivation to take care of yourself - Feeling unable to carry out your daily responsibilities - Psychotic symptoms in extreme cases — including hallucinations or delusions - Thoughts of death, [self harm](https://www.talkspace.com/blog/self-harm/), or suicidal thoughts When symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as [severe depression](https://www.talkspace.com/blog/severe-depression-signs-symptoms/). If you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or [online psychiatrist](https://www.talkspace.com/psychiatry). The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more. ## Types of Medications Used to Treat Depression There are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications. ### SSRIs Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression. SSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain. ### Popular SSRIs to treat mild or severe depression include: - Celexa (citalopram) - [Lexapro (escitalopram)](https://www.talkspace.com/psychiatry/medications/lexapro/) - Luvox (fluvoxamine) - Paxil/Pexeva/Brisdelle (paroxetine) - [Prozac/Sarafem (fluoxetine)](https://www.talkspace.com/psychiatry/medications/prozac/) - [Zoloft (sertraline)](https://www.talkspace.com/psychiatry/medications/zoloft/) #### Possible side effects of SSRIs to treat severe or mild depression: - Agitation - Feeling shaky or anxious - Indigestion - Diarrhea or constipation - Blurred vision - Loss of appetite - Weight loss - Dizziness - Sexual Side Effects ### SNRIs Serotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine *and* serotonin — SSRIs only work on serotonin levels. ### Popular SNRIs to treat depression include: - [Cymbalta (duloxetine)](https://www.talkspace.com/psychiatry/medications/cymbalta/) - Effexor XR (venlafaxine) - Fetzima (levomilnacipran) - Pristiq, Khedezla (desvenlafaxine) #### Possible side effects of SNRIs to treat depression: - Dry mouth - Nausea - Headache - Dizziness - Excessive sweating ### TCAs Tricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression. ### Popular TCAs to treat depression include: - Amitriptyline - Amoxapine - Anafranil (clomipramine) - Doxepin - Norpramin (desipramine) - Pamelor (nortriptyline) - Protriptyline - Surmontil (trimipramine) - Tofranil (imipramine) #### Possible side effects of TCAs to treat depression: - Slightly blurred vision - Dry mouth - Constipation - Dizziness - Drowsiness - Weight gain - Difficulty urinating - Excessive sweating (particularly at night) ### Dopamine reuptake blocker Another medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers. **There is only 1 dopamine Norepinephrine** **reuptake blocker on the market to treat depression:** - Aplenzin, Wellbutrin (bupropion) #### Possible side effects of dopamine reuptake blockers to treat depression: - Nausea - Insomnia - Weight loss - Headache - Constipation - Anxiety ### Tetracyclic antidepressant Tetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters. **There is only 1 tetracyclic antidepressant on the market to treat depression:** - Ludiomil (Maprotiline) #### Possible side effects of Maprotiline to treat depression: - Drowsiness - Nausea - Nightmares - Weakness - Tiredness - Sensitivity to sunlight - Dry mouth - Constipation - Change in appetite - Weight change ### 5-HT1A receptor antagonist An 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered. **There is only 1 5-HT1A receptor antagonist on the market to treat depression:** - Viibryd (vilazodone) #### Possible side effects of Viibryd to treat depression: - Nausea - Vomiting - Difficulty sleeping ### 5-HT2 receptor antagonists 5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression. **Popular 5-HT2 receptor antagonists to treat depression include:** - Nefazodone - [Oleptro (trazodone)](https://www.talkspace.com/psychiatry/medications/trazodone/) #### Possible side effects of 5-HT2 receptor antagonists to treat depression: - Hypotension - Dizziness - Headache - Fatigue ### 5-HT3 receptor antagonist The 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action **There is only 1 5-HT3 receptor antagonist on the market to treat depression:** - Brintellix (vortioxetine) #### Possible side effects of 5-HT3 receptor antagonists to treat depression: - Muscle tension - Headache - Mood swings - Dizziness - Sudden angry outbursts - Runny nose ### MAOIs Monoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well. ### Popular MAOIs to treat depression include: - Emsam (selegiline) - Marplan (isocarboxazid) - Nardil (phenelzine) - Parnate (tranylcypromine) #### Possible side effects of MAOIs to treat depression: - Nausea - Dry mouth - Diarrhea or constipation - Drowsiness - Headache - Insomnia - Dizziness - Lightheadedness ### Noradrenergic antagonist Primarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms. **There is only 1 noradrenergic antagonist on the market to treat depression:** - Remeron (mirtazapine) #### Possible side effects of Remeron to treat depression: - Sedation - Hallucinations - Agitation - Fever - Rapid/uneven heart rate - Loss of coordination - Stiff muscles - Confusion - Feeling unsteady - Tremors - Flu-like symptoms ## Medications Commonly Prescribed for Depression Because depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression. | | | | |---|---|---| | **Name Brand** | **Generic** | **Description** | | Lexapro | Escitalopram | An SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression. | | Celexa | Citalopram | SSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression. | | Zoloft | Sertraline | Another SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain. | | Paxil | Paroxetine | SSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications. | | Prozac | Fluoxetine | An antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression. | | Cymbalta | Duloxetine | An antidepressant that can treat depression and also treats nerve pain. | | Effexor | Venlafaxine | Antidepressant and nerve pain medication that is effective on depression and other anxiety disorders. | | Wellbutrin | Bupropion | Works in the brain and is used to treat depression; also a smoking cessation treatment. | | Desyrel, Desyrel Dividose, Oleptro, and Trazodone D | Trazodone | Antidepressant and sedative. | | Remeron | Mirtazapine | Antidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works. | | Pristiq | Desvenlafaxine | Treats major depressive disorder in adults. | | Abilify | Aripiprazole | Antipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome. | | Seroquel | Quetiapine | Another antipsychotic that treats depression as well as schizophrenia and bipolar disorder. | | Zyprexa | Olanzapine | Antipsychotic medication that works by helping to restore the balance of natural substances in the brain. | | Lithium | – | Mood stabilizer that can be used to treat mood disorders like depression. | | Lamictal | Lamotrigine | Prescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania. | Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. ### Online therapy for depression You don't have to deal with depression alone. Get an appointment from home within a few days. [Get started](https://www.talkspace.com/treatment/depression) ## How to Get Depression Medication Considering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression. In order to get medication for depression, the following steps should be taken: 1. **Get a diagnosis**To be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use [American Psychiatric Association’s](https://www.apa.org/) (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 2. **Begin therapy or treatment**Therapy can help you [manage depression](https://www.talkspace.com/blog/dealing-depression-need-know/). 3. **Consider medication** Medication can be prescribed in addition to treat your depression. 4. **Talk to your prescriber**A psychiatrist can help prescribe you the right medication for depression. ## Should You Treat Depression with Medication? Deciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking. Your doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering. It’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is *no* shame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) [reports](https://www.cdc.gov/nchs/products/databriefs/db377.htm) that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression. When you [talk to a prescriber or psychiatrist](https://www.talkspace.com/blog/tips-for-talking-with-a-psychiatrist-for-the-first-time/), you can ask any of the following. ### Questions to ask a prescriber: - **Should I consider depression medication?** Your prescriber can help you weigh the pros and cons of any depression medication that you may be considering. - **What are possible side effects of this medication?** It’s always important to understand potential [side effects of any medication](https://www.talkspace.com/blog/side-effects-medication-drugs/). This can help you make the best decision for you and your condition and determine whether or not a medication is right for you. - **What other treatments should I be considering for my depression?** Medication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression. - **Should I consider treatment in conjunction with depression medication?** Any time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying [online therapy](https://www.talkspace.com/online-therapy/) in addition to your medication. A psychiatrist can help you decide. - **Are there any holistic or self-help techniques I can try?** There are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression. - **Should I consider therapy in addition to medication?** Certain forms of talk therapy — like [cognitive behavioral therapy techniques](https://www.talkspace.com/blog/cbt-techniques/) — have proven effective in treating depression. - **Are there any other conditions going on that could be contributing to my depression?** Depression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines. If you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace. ### See References - ##### [Antidepressant Use Among Adults: United States, 2015-2018](https://www.cdc.gov/nchs/products/databriefs/db377.htm) Torres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021. - ##### [Dopamine Reuptake Inhibitors](https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/dopamine-reuptake-inhibitor) ScienceDirect. Accessed October 13, 2021. - ##### [American Psychological Association (APA)](https://www.apa.org/) Accessed October 17, 2021. - ##### [Antidepressant use among adults: United States, 2015–2018](https://www.cdc.gov/nchs/products/databriefs/db377.htm#Suggested_citation) Brody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021. ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2022/02/munir-headshot.png) [Dr. Muhammad Munir, MD](https://www.talkspace.com/mental-health/conditions/author/muhammadmunir/) Dr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing. 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Healthcare](https://www.talkspace.com/mental-health/conditions/articles/depression-in-nurses/) ![Featured Image](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif) **Depression** October 23, 2024 #### [Fatherhood Depression: Breaking the Silence on Depressed Dads](https://www.talkspace.com/mental-health/conditions/articles/fatherhood-depression/) ![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif) ### Learn more about Depression - ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-2.svg) ##### [Types of Depression](https://www.talkspace.com/mental-health/conditions/depression/types/) - ![Icon](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/icon-3.svg) ##### [Symptoms of 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##### Table of Contents: - [Overview](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-1) - [Types of Medications Used to Treat Depression](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-2) - [Medications Commonly Prescribed for Depression](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-3) - [How to Get Depression Medication](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-4) - [Should You Treat Depression with Medication?](https://www.talkspace.com/mental-health/conditions/depression/medications/#section-5) ## Our Editorial Standards ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-1-1.svg) Reviewed for Accuracy ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-3-1.svg) Up-to-date Research ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2023/04/editorial-Icon-2-1.svg) Credible References Updated On: August 19, 2025 ## Overview While [depression](https://www.talkspace.com/mental-health/conditions/depression/) is a common mental health condition that can begin at any age in life, it’s most commonly diagnosed in early adulthood. Because [depression affects the brain](https://www.talkspace.com/blog/how-does-depression-affect-the-brain/), some medication for depression has proven beneficial for treatment. The [American Psychiatric Association](https://www.psychiatry.org/patients-families/depression/what-is-depression) (APA) estimates that anywhere from 80% – 90% of people who seek treatment for their depression see positive results. Antidepressant medication is often the first line of treatment for depression medications. However, there are options for other types of medication and holistic or therapeutic treatments for depression, too. Depression can have a major impact on your life, and while depression medication isn’t necessarily a cure, it might help reduce or relieve some of the symptoms you may be experiencing. Major symptoms of depression can include: - Irritability - Feelings of hopelessness - Insomnia - Sleeping excessively - Weight gain or loss - Having a short temper or reacting quickly - Persistent and often uncontrollable thoughts about bad things happening - An inability or lack of motivation to take care of yourself - Feeling unable to carry out your daily responsibilities - Psychotic symptoms in extreme cases — including hallucinations or delusions - Thoughts of death, [self harm](https://www.talkspace.com/blog/self-harm/), or suicidal thoughts When symptoms of depression last for multiple weeks or begin to have a significant impact on how you function, you may be experiencing what’s known as [severe depression](https://www.talkspace.com/blog/severe-depression-signs-symptoms/). If you’re looking for the best medication for depression, you should learn more about your options. There are several types of depression medications that are often prescribed by an in-person or [online psychiatrist](https://www.talkspace.com/psychiatry). The first steps are getting a right diagnosis and knowing how you can get medication for depression and whether or not you should consider it in the first place. Keep reading to learn more. ## Types of Medications Used to Treat Depression There are a number of depression meds that may help treat your condition. It’s important to understand how they work and in what ways they can help before you begin taking any antidepression medications. ### SSRIs Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants often prescribed to treat depression. In fact, they’re the most commonly prescribed form of antidepressant medication used to treat depression. SSRIs work by lowering serotonin reuptake in your brain. Serotonin imbalance is thought to likely play a role in depression, so reducing the uptake allows the serotonin to work more effectively in the brain. ### Popular SSRIs to treat mild or severe depression include: - Celexa (citalopram) - [Lexapro (escitalopram)](https://www.talkspace.com/psychiatry/medications/lexapro/) - Luvox (fluvoxamine) - Paxil/Pexeva/Brisdelle (paroxetine) - [Prozac/Sarafem (fluoxetine)](https://www.talkspace.com/psychiatry/medications/prozac/) - [Zoloft (sertraline)](https://www.talkspace.com/psychiatry/medications/zoloft/) #### Possible side effects of SSRIs to treat severe or mild depression: - Agitation - Feeling shaky or anxious - Indigestion - Diarrhea or constipation - Blurred vision - Loss of appetite - Weight loss - Dizziness - Sexual Side Effects ### SNRIs Serotonin and norepinephrine reuptake inhibitors (SNRIs) improve norepinephrine and serotonin levels in the brain, which can reduce symptoms of depression. SNRIs differ from SSRIs because they work on increasing low levels of norepinephrine *and* serotonin — SSRIs only work on serotonin levels. ### Popular SNRIs to treat depression include: - [Cymbalta (duloxetine)](https://www.talkspace.com/psychiatry/medications/cymbalta/) - Effexor XR (venlafaxine) - Fetzima (levomilnacipran) - Pristiq, Khedezla (desvenlafaxine) #### Possible side effects of SNRIs to treat depression: - Dry mouth - Nausea - Headache - Dizziness - Excessive sweating ### TCAs Tricyclic antidepressants (TCAs) are an older generation of medication for depression. It’s not fully understood how TCAs work to improve depression. It’s thought that they’re effective because they block the action of the neurotransmitter acetylcholine while increasing levels of two other neurotransmitters, serotonin and norepinephrine, ultimately restoring balance in the brain and reducing symptoms of depression. ### Popular TCAs to treat depression include: - Amitriptyline - Amoxapine - Anafranil (clomipramine) - Doxepin - Norpramin (desipramine) - Pamelor (nortriptyline) - Protriptyline - Surmontil (trimipramine) - Tofranil (imipramine) #### Possible side effects of TCAs to treat depression: - Slightly blurred vision - Dry mouth - Constipation - Dizziness - Drowsiness - Weight gain - Difficulty urinating - Excessive sweating (particularly at night) ### Dopamine reuptake blocker Another medication for depression is a Norepinephrine- dopamine reuptake Inhibitor. It works by blocking the presynaptic uptake of noradrenaline (NA) and dopamine (DA). One benefit to this drug is some of the negative side effects (like weight gain and reduced sex drive) that are common to other antidepressants don’t seem to be a factor with dopamine reuptake blockers. **There is only 1 dopamine Norepinephrine** **reuptake blocker on the market to treat depression:** - Aplenzin, Wellbutrin (bupropion) #### Possible side effects of dopamine reuptake blockers to treat depression: - Nausea - Insomnia - Weight loss - Headache - Constipation - Anxiety ### Tetracyclic antidepressant Tetracyclic antidepressants can be prescribed to treat both depression as well as anxiety. Tetracyclic antidepressants work to ease depression symptoms by balancing out neurotransmitters. **There is only 1 tetracyclic antidepressant on the market to treat depression:** - Ludiomil (Maprotiline) #### Possible side effects of Maprotiline to treat depression: - Drowsiness - Nausea - Nightmares - Weakness - Tiredness - Sensitivity to sunlight - Dry mouth - Constipation - Change in appetite - Weight change ### 5-HT1A receptor antagonist An 5-HT1A receptor antagonist can balance neurotransmitters and serotonin levels in the brain, which can effectively treat depression. Note that 5-HT1A receptor antagonists typically aren’t a first-line treatment option for depression. Most often, other types of medication will be tried before an 5-HT1A receptor antagonist is offered. **There is only 1 5-HT1A receptor antagonist on the market to treat depression:** - Viibryd (vilazodone) #### Possible side effects of Viibryd to treat depression: - Nausea - Vomiting - Difficulty sleeping ### 5-HT2 receptor antagonists 5-HT2 receptor antagonists are older drugs used to treat depression. They work by altering the chemicals in your brain to reduce symptoms of depression. **Popular 5-HT2 receptor antagonists to treat depression include:** - Nefazodone - [Oleptro (trazodone)](https://www.talkspace.com/psychiatry/medications/trazodone/) #### Possible side effects of 5-HT2 receptor antagonists to treat depression: - Hypotension - Dizziness - Headache - Fatigue ### 5-HT3 receptor antagonist The 5-HT3 receptor antagonist can treat depression as well. It increases the release of several different neurotransmitters (serotonin, norepinephrine, dopamine, glutamate, acetylcholine, and histamine) and reduces the release of GABA through 3 different modes of action **There is only 1 5-HT3 receptor antagonist on the market to treat depression:** - Brintellix (vortioxetine) #### Possible side effects of 5-HT3 receptor antagonists to treat depression: - Muscle tension - Headache - Mood swings - Dizziness - Sudden angry outbursts - Runny nose ### MAOIs Monoamine oxidase inhibitors (MAOIs) are another older drug that is sometimes prescribed to treat depression. MAOIs work by hindering the breakdown of dopamine, norepinephrine, and serotonin. A caveat to MAOIs is they often interact with other drugs (both prescription and over the counter) and they may interact with some foods, as well. ### Popular MAOIs to treat depression include: - Emsam (selegiline) - Marplan (isocarboxazid) - Nardil (phenelzine) - Parnate (tranylcypromine) #### Possible side effects of MAOIs to treat depression: - Nausea - Dry mouth - Diarrhea or constipation - Drowsiness - Headache - Insomnia - Dizziness - Lightheadedness ### Noradrenergic antagonist Primarily used for depression treatment, noradrenergic antagonists can alter various chemicals in the brain, alleviating some common depression symptoms. **There is only 1 noradrenergic antagonist on the market to treat depression:** - Remeron (mirtazapine) #### Possible side effects of Remeron to treat depression: - Sedation - Hallucinations - Agitation - Fever - Rapid/uneven heart rate - Loss of coordination - Stiff muscles - Confusion - Feeling unsteady - Tremors - Flu-like symptoms ## Medications Commonly Prescribed for Depression Because depression significantly impacts the brain, drugs that work in your brain are likely the most helpful. The following depression medication list shares some of the more commonly prescribed medications for depression. | | | | |---|---|---| | **Name Brand** | **Generic** | **Description** | | Lexapro | Escitalopram | An SSRI used to restore balance of serotonin in the brain. Can improve energy level and feelings of well-being to help with symptoms of depression. | | Celexa | Citalopram | SSRI that can improve energy levels and feelings of well-being to alleviate symptoms of depression. | | Zoloft | Sertraline | Another SSRI that treats a variety of mood disorders. Helps with depression by restoring the balance of serotonin in the brain. | | Paxil | Paroxetine | SSRI that restores serotonin levels in the brain to treat depression and other anxiety disorders. Can be used alone or with other medications. | | Prozac | Fluoxetine | An antidepressant of the selective serotonin reuptake inhibitor (SSRI) class that’s used to treat depression. | | Cymbalta | Duloxetine | An antidepressant that can treat depression and also treats nerve pain. | | Effexor | Venlafaxine | Antidepressant and nerve pain medication that is effective on depression and other anxiety disorders. | | Wellbutrin | Bupropion | Works in the brain and is used to treat depression; also a smoking cessation treatment. | | Desyrel, Desyrel Dividose, Oleptro, and Trazodone D | Trazodone | Antidepressant and sedative. | | Remeron | Mirtazapine | Antidepressant used to treat symptoms of depression. It’s not fully understood how Remeron works. | | Pristiq | Desvenlafaxine | Treats major depressive disorder in adults. | | Abilify | Aripiprazole | Antipsychotic medication that treats depression and a host of other conditions like: schizophrenia, bipolar disorder, and Tourette syndrome. | | Seroquel | Quetiapine | Another antipsychotic that treats depression as well as schizophrenia and bipolar disorder. | | Zyprexa | Olanzapine | Antipsychotic medication that works by helping to restore the balance of natural substances in the brain. | | Lithium | – | Mood stabilizer that can be used to treat mood disorders like depression. | | Lamictal | Lamotrigine | Prescribed for maintenance treatment of bipolar I disorder; these are more effective against depressive episodes than mania. | Talk to your psychiatrist or healthcare professional about the possible risks and benefits associated with the above medications before starting treatment. ### Online therapy for depression You don't have to deal with depression alone. Get an appointment from home within a few days. ## How to Get Depression Medication Considering depression medication? You should talk to your doctor sooner than later. With their help, you can come up with the most effective course of treatment so you can learn to manage your depression. In order to get medication for depression, the following steps should be taken: 1. **Get a diagnosis**To be diagnosed, you’ll need a psychological and physical evaluation as well as lab tests. A mental health professional will likely use [American Psychiatric Association’s](https://www.apa.org/) (APA’s) criteria for depression listed in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). 2. **Begin therapy or treatment**Therapy can help you [manage depression](https://www.talkspace.com/blog/dealing-depression-need-know/). 3. **Consider medication** Medication can be prescribed in addition to treat your depression. 4. **Talk to your prescriber**A psychiatrist can help prescribe you the right medication for depression. ## Should You Treat Depression with Medication? Deciding to treat your depression with medication is a very personal decision but a lot times it is needed to prevent the worsening of the symptoms and prevent complications. Anytime you choose to take medication for a mental health condition, or for any health condition for that matter, it’s important that you understand as much as possible about what you’ll be taking. Your doctor or psychiatrist can fully discuss your treatment options and go over everything you need to know about any depression medication you’re considering. It’s important to keep in mind that the earlier you treat your depression, the more effective treatment tends to be. Equally important is understanding that there is *no* shame in taking medication for your depression. The Center for Disease Control and Prevention (CDC) [reports](https://www.cdc.gov/nchs/products/databriefs/db377.htm) that more than 13% of Americans took an antidepressant within a 30-day time period between 2015-2018. That number continues to grow, which means you’re not alone in dealing with your depression. When you [talk to a prescriber or psychiatrist](https://www.talkspace.com/blog/tips-for-talking-with-a-psychiatrist-for-the-first-time/), you can ask any of the following. ### Questions to ask a prescriber: - **Should I consider depression medication?** Your prescriber can help you weigh the pros and cons of any depression medication that you may be considering. - **What are possible side effects of this medication?** It’s always important to understand potential [side effects of any medication](https://www.talkspace.com/blog/side-effects-medication-drugs/). This can help you make the best decision for you and your condition and determine whether or not a medication is right for you. - **What other treatments should I be considering for my depression?** Medication isn’t your only option for treating depression. You can choose to combine depression meds with other treatments as well. Self-help techniques, therapy, and more can all be potentially helpful in treating depression. - **Should I consider treatment in conjunction with depression medication?** Any time you make the decision to begin medication for a health condition, it’s smart to look at what else you can do. For example, maybe you want to think about trying [online therapy](https://www.talkspace.com/online-therapy/) in addition to your medication. A psychiatrist can help you decide. - **Are there any holistic or self-help techniques I can try?** There are a number of self-help techniques and holistic tactics that you can implement to help manage depression. Things like journal writing, meditation, eating right, getting enough exercise and sleep might all help depression. - **Should I consider therapy in addition to medication?** Certain forms of talk therapy — like [cognitive behavioral therapy techniques](https://www.talkspace.com/blog/cbt-techniques/) — have proven effective in treating depression. - **Are there any other conditions going on that could be contributing to my depression?** Depression is related to multiple other mental and physical conditions. If not dealt with, it can either lead to or worsen existing conditions like depression, substance abuse, insomnia, digestive problems, and other physical health issues like headaches, bowel problems, or migraines. If you’re ready to start treating your mental health condition with depression medicine, connect with a prescriber at Talkspace. ### See References - ##### [Antidepressant Use Among Adults: United States, 2015-2018](https://www.cdc.gov/nchs/products/databriefs/db377.htm) Torres, M.D., MBA, DFAPA F. Products - Data Briefs - Number 377 - September 2020. Cdc.gov. Published 2020. Accessed October 13, 2021. - ##### [Dopamine Reuptake Inhibitors](https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/dopamine-reuptake-inhibitor) ScienceDirect. Accessed October 13, 2021. - ##### [American Psychological Association (APA)](https://www.apa.org/) Accessed October 17, 2021. - ##### [Antidepressant use among adults: United States, 2015–2018](https://www.cdc.gov/nchs/products/databriefs/db377.htm#Suggested_citation) Brody DJ, Gu Q. NCHS Data Brief, no 377. Hyattsville, MD: National Center for Health Statistics. 2020. Accessed October 13, 2021. ![](https://www.talkspace.com/mental-health/conditions/wp-content/uploads/sites/2/2022/02/munir-headshot.png) [Dr. Muhammad Munir, MD](https://www.talkspace.com/mental-health/conditions/author/muhammadmunir/) Dr. Muhammad Munir, MD, DFAPA, has over 20 years of clinical experience specializing in mood disorders, anxiety disorders, bipolar disorder, PTSD, panic disorder, and ADHD. Dr. Munir believes in “back to basics” the therapeutic alliance between the physician and patients. The hallmark of this alliance is the emphatic process whereby the patient is not only enabled, but educated and encouraged, to take an active role in their psychiatric care and wellbeing. ![](https://www.talkspace.com/mental-health/conditions/wp-content/themes/talkspace-conditions/assets/images/0.gif)

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