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| Meta Title | Suicide replaces Covid in top 10 causes of death, heart disease No. 1 | STAT |
| Meta Description | New CDC data on leading causes of death reveal changing risks and troubling trends. Suicide enters top 10, heart disease and cancer remain first and second. |
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| Boilerpipe Text | Covid-19 fell out of the top 10 causes of death in the United States in 2024, according to
new data
released Wednesday, and the estimated overall mortality rate declined to its lowest level since 2020.
Suicide took Covid’s place on the list.
Heart disease and cancer still rank as the first and second cause of death, with numbers that rose above last year’s mark for each disease. Unintentional injury, with more than a half-million fewer deaths than the leading causes, had the third-highest mortality rate.
While overall death rates decreased for all race and ethnicity groups, rates for Black people continue to be the highest. The gap between men and women also persists: The age-adjusted death rate per 100,000 people was 844.8 for males and 613.5 for females.
“Heart disease is still number one, and it’s definitely not going in the right direction,” Eric Topol, founder and director of Scripps Research in San Diego, told STAT. And lest we forget, “there are many thousands of people dying of Covid still.”
Deaths from heart disease rose in 2024 (683,037) compared with 2023 (680,981); deaths from cancer in 2024 (619,812) climbed from 2023 (613,352).
Stroke, chronic lower respiratory diseases, Alzheimer’s, diabetes, kidney disease, and chronic liver disease and cirrhosis followed, in descending order. Topol called four of the six — heart disease, cancer, stroke, and even Alzheimer’s — avoidable.
“These numbers are not encouraging,” he said. “We’re talking about diseases that are eminently preventable, just with lifestyle factors, but we have 75% of the population that doesn’t do even the minimum requirement of exercise.”
The U.S. numbers, compiled by the Centers for Disease Control and Prevention’s National Center for Health Statistics, do not compare well to other countries when it comes to health outcomes, life expectancy, infant mortality, and maternal mortality, among other measures.
Investment in public health
for chronic diseases lags behind the need, Topol noted, while fee-for-service health care is more reactive than preventive.
“The reduction of research support isn’t going to help matters,” he said. “It’s the U.S. Centers for Disease Control and Prevention. Where is the prevention?”
Topol has turned his research attention to developing polygenic scores that assess an individual’s specific disease risk in the hope of selecting the right prevention and improving longevity. He’ll start a prospective trial soon on the prevention of Alzheimer’s, but “if we had enough funding, we’d do one for cardiovascular and cancer,” he said.
If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat
988lifeline.org
. For TTY users: Use your preferred relay service or dial 711 then 988.
STAT’s coverage of chronic health issues is supported by a grant from
Bloomberg Philanthropies
. Our
financial supporters
are not involved in any decisions about our journalism. |
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# Covid-19 falls off list of top 10 causes of death in U.S.
## Death rates declined overall, but not for leading killers heart disease and cancer
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By [Elizabeth Cooney](https://www.statnews.com/staff/elizabeth-cooney/)
Sept. 10, 2025
Cardiovascular Disease Reporter

[Elizabeth Cooney](https://www.statnews.com/staff/elizabeth-cooney/)
[elizabeth.cooney@statnews.com](mailto:elizabeth.cooney@statnews.com "Email")
Elizabeth Cooney is a cardiovascular disease reporter at STAT, covering heart, stroke, and metabolic conditions. You can reach Liz on Signal at LizC.22.
[Get email alerts for Elizabeth CooneySigned up for email alertsRemove email alerts](https://www.statnews.com/2025/09/10/leading-cause-death-heart-disease-cancer-suicide/)
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Covid-19 fell out of the top 10 causes of death in the United States in 2024, according to [new data](https://dx.doi.org/10.15620/cdc/174621) released Wednesday, and the estimated overall mortality rate declined to its lowest level since 2020.
Suicide took Covid’s place on the list.
Advertisement
Heart disease and cancer still rank as the first and second cause of death, with numbers that rose above last year’s mark for each disease. Unintentional injury, with more than a half-million fewer deaths than the leading causes, had the third-highest mortality rate.
While overall death rates decreased for all race and ethnicity groups, rates for Black people continue to be the highest. The gap between men and women also persists: The age-adjusted death rate per 100,000 people was 844.8 for males and 613.5 for females.
“Heart disease is still number one, and it’s definitely not going in the right direction,” Eric Topol, founder and director of Scripps Research in San Diego, told STAT. And lest we forget, “there are many thousands of people dying of Covid still.”
Advertisement
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### [Down to their heart cells, women and men have cardiovascular differences that matter](https://www.statnews.com/2025/03/31/heart-disease-women-dei-bans-threaten-research-sex-differences-in-cardiovascular-disease/)
Deaths from heart disease rose in 2024 (683,037) compared with 2023 (680,981); deaths from cancer in 2024 (619,812) climbed from 2023 (613,352).
Stroke, chronic lower respiratory diseases, Alzheimer’s, diabetes, kidney disease, and chronic liver disease and cirrhosis followed, in descending order. Topol called four of the six — heart disease, cancer, stroke, and even Alzheimer’s — avoidable.
“These numbers are not encouraging,” he said. “We’re talking about diseases that are eminently preventable, just with lifestyle factors, but we have 75% of the population that doesn’t do even the minimum requirement of exercise.”
The U.S. numbers, compiled by the Centers for Disease Control and Prevention’s National Center for Health Statistics, do not compare well to other countries when it comes to health outcomes, life expectancy, infant mortality, and maternal mortality, among other measures. [Investment in public health](https://www.statnews.com/2025/06/07/rfk-jr-administration-for-healthy-america-chronic-disease-budget-documents/) for chronic diseases lags behind the need, Topol noted, while fee-for-service health care is more reactive than preventive.
“The reduction of research support isn’t going to help matters,” he said. “It’s the U.S. Centers for Disease Control and Prevention. Where is the prevention?”
Topol has turned his research attention to developing polygenic scores that assess an individual’s specific disease risk in the hope of selecting the right prevention and improving longevity. He’ll start a prospective trial soon on the prevention of Alzheimer’s, but “if we had enough funding, we’d do one for cardiovascular and cancer,” he said.
*If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat* [*988lifeline.org*](http://988lifeline.org/)*. For TTY users: Use your preferred relay service or dial 711 then 988.*
*STAT’s coverage of chronic health issues is supported by a grant from* [*Bloomberg Philanthropies*](https://www.bloomberg.org/)*. Our* [*financial supporters*](https://www.statnews.com/supporters/) *are not involved in any decisions about our journalism.*
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[Elizabeth Cooney](https://www.statnews.com/staff/elizabeth-cooney/)
Cardiovascular Disease Reporter
Elizabeth Cooney is a cardiovascular disease reporter at STAT, covering heart, stroke, and metabolic conditions. You can reach Liz on Signal at LizC.22.


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| Readable Markdown | Covid-19 fell out of the top 10 causes of death in the United States in 2024, according to [new data](https://dx.doi.org/10.15620/cdc/174621) released Wednesday, and the estimated overall mortality rate declined to its lowest level since 2020.
Suicide took Covid’s place on the list.
Heart disease and cancer still rank as the first and second cause of death, with numbers that rose above last year’s mark for each disease. Unintentional injury, with more than a half-million fewer deaths than the leading causes, had the third-highest mortality rate.
While overall death rates decreased for all race and ethnicity groups, rates for Black people continue to be the highest. The gap between men and women also persists: The age-adjusted death rate per 100,000 people was 844.8 for males and 613.5 for females.
“Heart disease is still number one, and it’s definitely not going in the right direction,” Eric Topol, founder and director of Scripps Research in San Diego, told STAT. And lest we forget, “there are many thousands of people dying of Covid still.”
Deaths from heart disease rose in 2024 (683,037) compared with 2023 (680,981); deaths from cancer in 2024 (619,812) climbed from 2023 (613,352).
Stroke, chronic lower respiratory diseases, Alzheimer’s, diabetes, kidney disease, and chronic liver disease and cirrhosis followed, in descending order. Topol called four of the six — heart disease, cancer, stroke, and even Alzheimer’s — avoidable.
“These numbers are not encouraging,” he said. “We’re talking about diseases that are eminently preventable, just with lifestyle factors, but we have 75% of the population that doesn’t do even the minimum requirement of exercise.”
The U.S. numbers, compiled by the Centers for Disease Control and Prevention’s National Center for Health Statistics, do not compare well to other countries when it comes to health outcomes, life expectancy, infant mortality, and maternal mortality, among other measures. [Investment in public health](https://www.statnews.com/2025/06/07/rfk-jr-administration-for-healthy-america-chronic-disease-budget-documents/) for chronic diseases lags behind the need, Topol noted, while fee-for-service health care is more reactive than preventive.
“The reduction of research support isn’t going to help matters,” he said. “It’s the U.S. Centers for Disease Control and Prevention. Where is the prevention?”
Topol has turned his research attention to developing polygenic scores that assess an individual’s specific disease risk in the hope of selecting the right prevention and improving longevity. He’ll start a prospective trial soon on the prevention of Alzheimer’s, but “if we had enough funding, we’d do one for cardiovascular and cancer,” he said.
*If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat* [*988lifeline.org*](http://988lifeline.org/)*. For TTY users: Use your preferred relay service or dial 711 then 988.*
*STAT’s coverage of chronic health issues is supported by a grant from* [*Bloomberg Philanthropies*](https://www.bloomberg.org/)*. Our* [*financial supporters*](https://www.statnews.com/supporters/) *are not involved in any decisions about our journalism.* |
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