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| Meta Title | What Are the Side Effects of Melatonin? - Sleep Advisor |
| Meta Description | Discover comprehensive information about the safety and potential side effects of melatonin, along with additional tips and insights. |
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| Boilerpipe Text | Our Research Process
Here at Sleep Advisor, our editorial team utilizes reputable sources and expert feedback to provide well-researched sleep health content. For more details, read our full
editorial policy
.Â
In This Article
Discover comprehensive information about the safety and potential side effects of melatonin, along with additional tips and insights.
Melatonin is a hormone that we all naturally produce. Its production
increases when it is dark
1
, signaling to our bodies that it is time to get sleepy, and it decreases when it becomes light, signaling to our bodies it is time to wake up.Â
Melatonin supplements, on the other hand, are often created synthetically, and you can take them in the form of capsules, tablets, liquids, gummies,
or even patches
2
. These are used to
help people sleep
3
by helping to regulate their
circadian rhythm
, the body’s natural sleep-wake cycle.Â
Melatonin is generally considered safe to take on a temporary basis, especially if people find it beneficial.
1
However, that doesn’t mean it can’t have side effects.Â
Read Our Guide:
Melatonin: Everything You Should Know
Side Effects of MelatoninÂ
Experts consider occasional or short-term melatonin use to be safe for most people, and the risk of side effects is low.
2, 3
Â
That said, there are
possible side effects
4
that can happen when taking melatonin.Â
Daytime fatigue
– The most common side effect of melatonin is fatigue in the morning after taking it.
4
If this happens to you, try lowering your dose and making sure you’re taking it two hours before bed.
3Â
Headache
– Melatonin may cause a headache in some people. To combat this, England’s National Health Service (NHS) recommends drinking plenty of water if you’re taking melatonin. They also advise avoiding alcohol because it can make you dehydrated and impact the way melatonin works.
4
Â
Stomach issues
– Some people report stomach aches or nausea when using melatonin.
4
That said, some research has shown that melatonin may help with IBS due to its slight pain-relieving effects.
2
Additionally, its ability to regulate the
circadian rhythms of our gut bacteria
5
could be helpful as well.
Dizziness
– The NHS recommends avoiding driving, cycling, or using any tools or machinery if melatonin has made you dizzy. Additionally, alcohol can worsen your dizziness, so avoid mixing melatonin and alcohol.
4
Â
Irritability
– Some people report irritability or restlessness when taking melatonin.
4
If this happens to you, it may very well be because you’re taking too high a dose.
2
Try lowering your dose, and if this doesn’t work, stop taking melatonin.Â
More vivid or strange dreams
– According to the NHS, taking melatonin may lead to more strange dreams.
4
Supplemental melatonin can increase the
amount of time spent in REM sleep
6
, which is the portion of our sleep cycle when vivid dreams are more likely to occur. This means you could be more likely to dream since you’re in REM sleep longer, however, experts say it’s not clear whether melatonin directly causes more vivid dreaming.
6
Melatonin may also interact with other medications and/or supplements, so we encourage anyone considering melatonin to contact their healthcare provider first.
Side Effects of Melatonin in ChildrenÂ
Supplemental melatonin is generally considered
safe for kids
7
as long as the dose is appropriate and any behavioral or environmental issues impacting sleep are also addressed. However, melatonin may affect children differently than adults.Â
For example, experts say that melatonin production
declines at the onset of puberty
8
.Â
Since this drop in melatonin is a natural process before puberty, some experts hypothesize that giving your prepubescent child melatonin could delay puberty, though more research is needed to confirm this.
8
Children may also be more susceptible to nightmares and vivid dreams with melatonin supplements. Kids naturally
spend more time in REM sleep
9
, and as mentioned, taking supplemental melatonin seems to increase the time spent in REM sleep, which is when vivid dreams and nightmares often occur.
6
Â
Other side effects for children taking melatonin are similar to those of adults: headaches, dizziness, mood changes, and morning grogginess.
7
These side effects should disappear with discontinuation.Â
It’s also important to note that most of the research done on children and melatonin is in kids with ADHD rather than kids without attention disorders. Therefore, more research is needed.Â
Learn more
:
A Guide to Melatonin for Kids
Â
Melatonin Safety
Before taking any new supplements or altering your current dose, we strongly encourage you to consult your healthcare provider.Â
When taking melatonin it is important to remember that more is not always
better. Some experts advise taking 1 to 3 milligrams two hours before bed.
3
That said, this dosage is a general recommendation, and you should discuss dosage with your healthcare provider to ensure you take the proper amount for you.Â
Melatonin timing is important because two hours before bedtime is about when your body naturally starts producing melatonin in the absence of artificial light.
1
So to help maximize its effectiveness, you’ll also want to dim the lights and stop looking at screens at about this time.
3
Â
If lowering the dose and taking it earlier does not mitigate your side effects, you can stop taking melatonin at any time without worrying about
weaning off of it
10
. Unlike other sleep medications where you need to take more of it over time or experience a “hangover” effect in the morning, melatonin is considered to be
non-addictive or habit-forming from a physiological standpoint
11
.Â
However, it’s important to note that because melatonin is sold as a dietary supplement in the United States, it is not as strictly regulated by the Food and Drug Administration (FDA) as prescription medications. This means that when you buy your melatonin supplement, you’ll have no real way of knowing how much melatonin (or other ingredients) are actually in the supplement unless the brand does third-party testing, which is not industry standard at the moment unfortunately.
2Â
This is why it is important to buy a melatonin supplement from a high-quality, reputable brand. For example, look for supplements approved by the
U.S. Pharmacopeia
12
, a third-party organization that helps provide product transparency for consumers. You can look for the words “USP verified” on the label.Â
Who Should Avoid Melatonin?
Although this supplement is generally considered safe, certain populations should
avoid taking melatonin
13
.Â
Those who have a melatonin allergy
– If you’ve ever had an allergic reaction to a supplement containing melatonin or any other medication, you should not take melatonin.
13
Â
Those with liver or kidney problems
– The National Health Service advises against taking melatonin for those with liver or kidney problems.
13
However, there has been research looking at melatonin’s role in potentially
healing the liver
14
and
kidneys
15
, so more information is needed.Â
Those taking medications that could interact
– Melatonin may interact with certain medications, potentially impacting their efficacy. According to the
Mayo Clinic
16
, these include drugs for blood clots, seizures, blood pressure, the central nervous system, diabetes, and contraception — among others.Â
People with autoimmune disorders
– If you have lupus, multiple sclerosis, rheumatoid arthritis, or any other autoimmune condition, you should avoid supplemental melatonin as it may stimulate inflammation.
13
Â
Can You Overdose on Melatonin?Â
Let’s quickly clarify the difference between an overdose and a lethal dose.
An overdose
17
means you’ve taken too much of something (a “toxic” amount) and are experiencing side effects as a result. A lethal dose means you have taken so much of something that it kills you.Â
You can overdose on melatonin, meaning you can take too much of it and experience side effects. The most common
side effects of a melatonin overdose
18
are drowsiness, dizziness, headache, fatigue, confusion, bad dreams, hypothermia, tachycardia, and hypotension.
Learn more:
Can You
Overdose on Melatonin?
When Should You Seek Medical Help?Â
More serious melatonin side effects are rare, affecting less than 1 in 1,000 people. That said, if after taking melatonin you experience changes in your eyesight, feel faint or pass out, start feeling confused, experience vertigo, or have unexplained bruising or bleeding that does not stop, you should discontinue use and call your healthcare provider or 911.
4
Â
In very rare cases, it is possible to have a
serious allergic reaction to melatonin
, which includes symptoms such as
4
:
Sudden swelling of the lips, tongue, mouth, or throat
Struggling to breathe
Inability to swallow
The skin, tongue, or lips suddenly turn blue, gray, or pale
A skin rash that is swollen, itchy, blistered, or peeling
Sudden confusion, dizziness, or drowsiness
Fainting and not waking up
A child going limp, floppy, or not responding as they normally do
If any of these symptoms of an allergic reaction occur after taking melatonin, you should discontinue use and seek emergency medical care.Â
Additional Sleep TipsÂ
If you either can’t or would prefer not to take melatonin, there are other ways to
get better sleep
through daily sleep hygiene habits. Many of these can also complement the effects of melatonin supplementation.Â
Increase your melatonin naturally
– You can help your body’s natural melatonin production by dimming the lights at night and cutting off screen devices like smartphones and laptops at least one hour before bed.
1
You can also eat more
melatonin-boosting foods
19
like eggs, fish, nuts, seeds, legumes, mushrooms, and certain cereals.Â
Establish a regular sleep schedule
– Going to bed and waking up at the same time each day can help regulate your circadian rhythm and get your sleep schedule back on track.Â
Practice a nightly routine
– Introducing a regular, relaxing nighttime routine can help you wind down before bed and tell your body it’s time to rest. Some great examples of nighttime rituals are baths, reading a book, journaling, meditation, or gentle stretching.
Create an ideal sleep environment
–
Your bedroom
should be dark to promote melatonin production. However, keeping it cool and quiet can also foster better sleep. Additionally, sleeping on a
quality mattress
and comfortable bedding can help you feel even more ready for sleep.
Avoid alcohol at night
– Research shows that
alcohol negatively impacts sleep
20
. Therefore, avoid consuming alcohol at night if you’re having sleep issues.Â
Stop drinking caffeine in the afternoon
– You should have your last cup of coffee at least
six hours
21
before you plan to go to bed since caffeine can stay in your system for up to six hours.Â
Avoid large meals at night
– Eating a big meal late at night could negatively impact your sleep, possibly causing discomfort or indigestion. Research shows that eating
three hours
22
or more before bed is ideal.
Add in regular exercise
– Regular exercise
has been proven
23
to help you fall asleep more quickly and improve overall sleep quality.Â
Limit afternoon naps
– Afternoon naps can impact your ability to fall asleep at night. If you do need to take a nap, limit it to
10 to 20 minutes
24
so it won’t negatively impact your sleep that night.
Try magnesium instead
– Certain types of
magnesium supplements
may help with sleep. Just like with melatonin, speak with your healthcare provider before introducing any to your daily routine.
Learn more:
Magnesium vs. Melatonin
Frequently Asked Questions |
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# What Are the Side Effects of Melatonin?
Last Updated on June 6, 2024
Written by [Natalie Grigson](https://www.sleepadvisor.org/author/natalie-g/ "Natalie Grigson"), Expert Reviewed by [Dr. Swathi Varanasi](https://www.sleepadvisor.org/author/swathiv/ "Dr. Swathi Varanasi")
[](https://www.sleepadvisor.org/natalie-g/)
## Written by [Natalie Grigson, Writer](https://www.sleepadvisor.org/natalie-g/)
### Our Research Process
Here at Sleep Advisor, our editorial team utilizes reputable sources and expert feedback to provide well-researched sleep health content. For more details, read our full [editorial policy](https://www.sleepadvisor.org/editorial-policy/).
### In This Article
Discover comprehensive information about the safety and potential side effects of melatonin, along with additional tips and insights.
»
Table of Contents
[Side Effects of Melatonin](https://www.sleepadvisor.org/what-are-the-side-effects-of-melatonin/#side-effects-of-melatonin-) [Melatonin Safety](https://www.sleepadvisor.org/what-are-the-side-effects-of-melatonin/#melatonin-safety) [Additional Sleep Tips](https://www.sleepadvisor.org/what-are-the-side-effects-of-melatonin/#additional-sleep-tips-) [Frequently Asked Questions](https://www.sleepadvisor.org/what-are-the-side-effects-of-melatonin/#frequently-asked-questions)
Melatonin is a hormone that we all naturally produce. Its production [increases when it is dark](https://www.ncbi.nlm.nih.gov/books/NBK550972/)1, signaling to our bodies that it is time to get sleepy, and it decreases when it becomes light, signaling to our bodies it is time to wake up.
Melatonin supplements, on the other hand, are often created synthetically, and you can take them in the form of capsules, tablets, liquids, gummies, [or even patches](https://www.ncbi.nlm.nih.gov/books/NBK534823/)2. These are used to [help people sleep](https://www.hopkinsmedicine.org/health/wellness-and-prevention/melatonin-for-sleep-does-it-work)3 by helping to regulate their [circadian rhythm](https://www.sleepadvisor.org/what-is-circadian-rhythm/), the body’s natural sleep-wake cycle.
Melatonin is generally considered safe to take on a temporary basis, especially if people find it beneficial.1 However, that doesn’t mean it can’t have side effects.
**Read Our Guide:** [Melatonin: Everything You Should Know](https://www.sleepadvisor.org/melatonin/)
## Side Effects of Melatonin
Experts consider occasional or short-term melatonin use to be safe for most people, and the risk of side effects is low.2, 3
That said, there are [possible side effects](https://www.nhs.uk/medicines/melatonin/side-effects-of-melatonin/)4 that can happen when taking melatonin.
- **Daytime fatigue** – The most common side effect of melatonin is fatigue in the morning after taking it.4 If this happens to you, try lowering your dose and making sure you’re taking it two hours before bed.3
- **Headache** – Melatonin may cause a headache in some people. To combat this, England’s National Health Service (NHS) recommends drinking plenty of water if you’re taking melatonin. They also advise avoiding alcohol because it can make you dehydrated and impact the way melatonin works.4
- **Stomach issues** – Some people report stomach aches or nausea when using melatonin.4 That said, some research has shown that melatonin may help with IBS due to its slight pain-relieving effects.2 Additionally, its ability to regulate the [circadian rhythms of our gut bacteria](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959415/)5 could be helpful as well.
- **Dizziness** – The NHS recommends avoiding driving, cycling, or using any tools or machinery if melatonin has made you dizzy. Additionally, alcohol can worsen your dizziness, so avoid mixing melatonin and alcohol.4
- **Irritability** – Some people report irritability or restlessness when taking melatonin.4 If this happens to you, it may very well be because you’re taking too high a dose.2 Try lowering your dose, and if this doesn’t work, stop taking melatonin.
- **More vivid or strange dreams** – According to the NHS, taking melatonin may lead to more strange dreams.4 Supplemental melatonin can increase the [amount of time spent in REM sleep](https://health.clevelandclinic.org/does-melatonin-cause-bad-dreams)6, which is the portion of our sleep cycle when vivid dreams are more likely to occur. This means you could be more likely to dream since you’re in REM sleep longer, however, experts say it’s not clear whether melatonin directly causes more vivid dreaming.6
**Melatonin may also interact with other medications and/or supplements, so we encourage anyone considering melatonin to contact their healthcare provider first.**
### Side Effects of Melatonin in Children
Supplemental melatonin is generally considered [safe for kids](https://answers.childrenshospital.org/melatonin-for-children/)7 as long as the dose is appropriate and any behavioral or environmental issues impacting sleep are also addressed. However, melatonin may affect children differently than adults.
For example, experts say that melatonin production [declines at the onset of puberty](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/)8.
Since this drop in melatonin is a natural process before puberty, some experts hypothesize that giving your prepubescent child melatonin could delay puberty, though more research is needed to confirm this.8
Children may also be more susceptible to nightmares and vivid dreams with melatonin supplements. Kids naturally [spend more time in REM sleep](https://kidshealth.org/en/parents/sleep.html)9, and as mentioned, taking supplemental melatonin seems to increase the time spent in REM sleep, which is when vivid dreams and nightmares often occur.6
Other side effects for children taking melatonin are similar to those of adults: headaches, dizziness, mood changes, and morning grogginess.7 These side effects should disappear with discontinuation.
It’s also important to note that most of the research done on children and melatonin is in kids with ADHD rather than kids without attention disorders. Therefore, more research is needed.
**Learn more**: [A Guide to Melatonin for Kids](https://www.sleepadvisor.org/melatonin-for-kids/)
***
## Melatonin Safety
****Before taking any new supplements or altering your current dose, we strongly encourage you to consult your healthcare provider.****
When taking melatonin it is important to remember that more is not alwaysbetter. Some experts advise taking 1 to 3 milligrams two hours before bed.3 That said, this dosage is a general recommendation, and you should discuss dosage with your healthcare provider to ensure you take the proper amount for you.
Melatonin timing is important because two hours before bedtime is about when your body naturally starts producing melatonin in the absence of artificial light.1 So to help maximize its effectiveness, you’ll also want to dim the lights and stop looking at screens at about this time.3
If lowering the dose and taking it earlier does not mitigate your side effects, you can stop taking melatonin at any time without worrying about [weaning off of it](https://health.clevelandclinic.org/melatonin-dependency)10. Unlike other sleep medications where you need to take more of it over time or experience a “hangover” effect in the morning, melatonin is considered to be [non-addictive or habit-forming from a physiological standpoint](https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/melatonin-side-effects/faq-20057874)11.
However, it’s important to note that because melatonin is sold as a dietary supplement in the United States, it is not as strictly regulated by the Food and Drug Administration (FDA) as prescription medications. This means that when you buy your melatonin supplement, you’ll have no real way of knowing how much melatonin (or other ingredients) are actually in the supplement unless the brand does third-party testing, which is not industry standard at the moment unfortunately.2
This is why it is important to buy a melatonin supplement from a high-quality, reputable brand. For example, look for supplements approved by the [U.S. Pharmacopeia](https://www.ncbi.nlm.nih.gov/books/NBK218324/)12, a third-party organization that helps provide product transparency for consumers. You can look for the words “USP verified” on the label.
### Who Should Avoid Melatonin?
Although this supplement is generally considered safe, certain populations should [avoid taking melatonin](https://www.nhs.uk/medicines/melatonin/who-can-and-cannot-take-melatonin/)13.
- **Those who have a melatonin allergy** – If you’ve ever had an allergic reaction to a supplement containing melatonin or any other medication, you should not take melatonin.13
- **Those with liver or kidney problems** – The National Health Service advises against taking melatonin for those with liver or kidney problems.13 However, there has been research looking at melatonin’s role in potentially [healing the liver](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412268/)14 and [kidneys](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047594/)15, so more information is needed.
- **Those taking medications that could interact** – Melatonin may interact with certain medications, potentially impacting their efficacy. According to the [Mayo Clinic](https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071)16, these include drugs for blood clots, seizures, blood pressure, the central nervous system, diabetes, and contraception — among others.
- **People with autoimmune disorders** – If you have lupus, multiple sclerosis, rheumatoid arthritis, or any other autoimmune condition, you should avoid supplemental melatonin as it may stimulate inflammation.13
### Can You Overdose on Melatonin?
Let’s quickly clarify the difference between an overdose and a lethal dose. [An overdose](https://www.betterhealth.vic.gov.au/health/healthyliving/drug-overdose)17 means you’ve taken too much of something (a “toxic” amount) and are experiencing side effects as a result. A lethal dose means you have taken so much of something that it kills you.
You can overdose on melatonin, meaning you can take too much of it and experience side effects. The most common [side effects of a melatonin overdose](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567778/)18 are drowsiness, dizziness, headache, fatigue, confusion, bad dreams, hypothermia, tachycardia, and hypotension.
**Learn more:** Can You [Overdose on Melatonin?](https://www.sleepadvisor.org/can-you-overdose-on-melatonin/)
### When Should You Seek Medical Help?
More serious melatonin side effects are rare, affecting less than 1 in 1,000 people. That said, if after taking melatonin you experience changes in your eyesight, feel faint or pass out, start feeling confused, experience vertigo, or have unexplained bruising or bleeding that does not stop, you should discontinue use and call your healthcare provider or 911.4
In very rare cases, it is possible to have a **serious allergic reaction to melatonin**, which includes symptoms such as4:
- Sudden swelling of the lips, tongue, mouth, or throat
- Struggling to breathe
- Inability to swallow
- The skin, tongue, or lips suddenly turn blue, gray, or pale
- A skin rash that is swollen, itchy, blistered, or peeling
- Sudden confusion, dizziness, or drowsiness
- Fainting and not waking up
- A child going limp, floppy, or not responding as they normally do
If any of these symptoms of an allergic reaction occur after taking melatonin, you should discontinue use and seek emergency medical care.
***
## Additional Sleep Tips
If you either can’t or would prefer not to take melatonin, there are other ways to [get better sleep](https://www.sleepadvisor.org/how-to-get-better-sleep/) through daily sleep hygiene habits. Many of these can also complement the effects of melatonin supplementation.
- **Increase your melatonin naturally** – You can help your body’s natural melatonin production by dimming the lights at night and cutting off screen devices like smartphones and laptops at least one hour before bed.1 You can also eat more [melatonin-boosting foods](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409706/)19 like eggs, fish, nuts, seeds, legumes, mushrooms, and certain cereals.
- **Establish a regular sleep schedule** – Going to bed and waking up at the same time each day can help regulate your circadian rhythm and get your sleep schedule back on track.
- **Practice a nightly routine** – Introducing a regular, relaxing nighttime routine can help you wind down before bed and tell your body it’s time to rest. Some great examples of nighttime rituals are baths, reading a book, journaling, meditation, or gentle stretching.
- **Create an ideal sleep environment** – [Your bedroom](https://www.sleepadvisor.org/sleep-enviroment/) should be dark to promote melatonin production. However, keeping it cool and quiet can also foster better sleep. Additionally, sleeping on a [quality mattress](https://www.sleepadvisor.org/best-mattress/) and comfortable bedding can help you feel even more ready for sleep.
- **Avoid alcohol at night** – Research shows that [alcohol negatively impacts sleep](https://pubmed.ncbi.nlm.nih.gov/31128400/)20. Therefore, avoid consuming alcohol at night if you’re having sleep issues.
- **Stop drinking caffeine in the afternoon** – You should have your last cup of coffee at least [six hours](https://www.houstonmethodist.org/blog/articles/2021/oct/caffeine-sleep-how-long-does-caffeine-keep-you-awake/)21 before you plan to go to bed since caffeine can stay in your system for up to six hours.
- **Avoid large meals at night** – Eating a big meal late at night could negatively impact your sleep, possibly causing discomfort or indigestion. Research shows that eating [three hours](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215804/)22 or more before bed is ideal.
- **Add in regular exercise** – Regular exercise [has been proven](https://www.hopkinsmedicine.org/health/wellness-and-prevention/exercising-for-better-sleep)23 to help you fall asleep more quickly and improve overall sleep quality.
- **Limit afternoon naps** – Afternoon naps can impact your ability to fall asleep at night. If you do need to take a nap, limit it to [10 to 20 minutes](https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/napping/art-20048319)24 so it won’t negatively impact your sleep that night.
- **Try magnesium instead** – Certain types of [magnesium supplements](https://www.sleepadvisor.org/best-magnesium-for-sleep/) may help with sleep. Just like with melatonin, speak with your healthcare provider before introducing any to your daily routine.
**Learn more:** [Magnesium vs. Melatonin](https://www.sleepadvisor.org/magnesium-vs-melatonin/)
***
## Frequently Asked Questions
What are the negative side effects of melatonin?
Melatonin is generally considered to be safe with a low risk of side effects.2, 3 However, if you do experience melatonin side effects, they are most likely to be morning fatigue, headache, grogginess, vivid dreams, upset stomach, or irritability.4 If you experience any of these melatonin side effects, you can try lowering the dose or you can stop taking the supplements completely. Side effects should disappear with discontinuation.
Is 10 milligrams of melatonin too much?
In general, it’s advised that people start with smaller doses, such as 1-3 milligrams two hours before bedtime.3 While 10 milligrams hasn’t been associated with negative side effects, [researchers recommend](https://pubmed.ncbi.nlm.nih.gov/11027741/)25 doctor supervision at a dose this high.
Is it harmful to take melatonin every night?
Traditionally, healthcare providers have recommended taking melatonin supplements only occasionally or short-term (one to two months).3 However, research is being conducted about melatonin’s potential benefits and risks when [taken long-term](https://pubmed.ncbi.nlm.nih.gov/36976674/)26, especially in certain populations.
[Back To Top](https://www.sleepadvisor.org/what-are-the-side-effects-of-melatonin/)

## Natalie Grigson
Writer
### About Author
Natalie is a content writer for Sleep Advisor with a deep passion for all things health and a fascination with the mysterious activity that is sleep. Outside of writing about sleep, she is a bestselling author, improviser, and creative writing teacher based out of Austin.
Side Sleeper
**References:**
1. Arendt PhD, Josephine., Aulinas MD PhD, Anna. “Physiology of the Pineal Gland and Melatonin”. *Endotext*. Last modified October 30, 2022.
2. Savage, Rosemary A., et al. “Melatonin”. StatPearls. Last modified August 8, 2022.
3. “Melatonin for Sleep: Does It Work?”. Johns Hopkins Medicine. Webpage accessed December 31, 2023.
4. “Side effects of melatonin”. National Health Service. Last modified February 13, 2023.
5. Fowler, Sophie., et al. “Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions”. *Frontiers in Neuroscience*. 2022.
6. “Can Melatonin Cause Bad Dreams? What Experts Say”. Cleveland Clinic. 2021.
7. Fliesler, Nancy. “Melatonin for kids: Is it effective? Is it safe?”. Boston Children’s Hospital. 2022.
8. Boafo, Addo., et al. “Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician’s perspective”. *Nature and Science of Sleep*. 2019.
9. Gavin MD, Mary L. “Kids and Sleep”. NEMOURS KidsHealth. Last modified January 2021.
10. “The Truth About Melatonin Addiction”. Cleveland Clinic. 2022.
11. Bauer MD, Brent A. “Is melatonin a helpful sleep aid — and what should I know about melatonin side effects?”. Mayo Clinic. 2022.
12. “United States Pharmacopeial Convention”. National Library of Medicine. 1988.
13. “Who can and cannot take melatonin”. National Health Service. Last modified February 13, 2023.
14. Zhang, Jiao-Jiao., et al. “Effects of Melatonin on Liver Injuries and Diseases”. *International Journal of Molecular Sciences*. 2017.
15. Markowska, Magdalena., Niemczyk, Stanisław., Romejko, Katarzyna. “Melatonin Treatment in Kidney Diseases”. *Cells*. 2023.
16. “Melatonin”. Mayo Clinic. Last modified August 10, 2023.
17. “Drug overdose”. BetterHealth Channel. Webpage accessed January 1, 2024.
18. Higueras, T. Gutierrez, et al. “Attempted suicide by Melatonin overdose: Case report and literature review”. *European Psychiatry*. 2022.
19. Meng, Xiao., et al. “Dietary Sources and Bioactivities of Melatonin”. *Nutrients*. 2017.
20. He, Sean., Hasler, Brant P., Chakravorty, Subhajit. “Alcohol and sleep-related problems”. National Library of Medicine. 2019.
21. McCallum, Katie. “Caffeine & Sleep: How Long Does Caffeine Keep You Awake?”. Houston Methodist Hospital. 2023.
22. Chung, Nikola., et al. “Does the Proximity of Meals to Bedtime Influence the Sleep of Young Adults? A Cross-Sectional Survey of University Students”. International Journal of Environmental Research and Public Health. 2020.
23. “Exercising for Better Sleep”. Johns Hopkins Medicine. Webpage accessed January 1, 2024.
24. “Napping: Do’s and don’ts for healthy adults”. Mayo Clinic. Last modified November 9, 2022.
25. Sack, R.L., et al. “Entrainment of free-running circadian rhythms by melatonin in blind people”. National Library of Medicine. 2000.
26. Givler, Donald., et al. “Chronic Administration of Melatonin: Physiological and Clinical Considerations”. National Library of Medicine. 2023.

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| Readable Markdown | ### Our Research Process
Here at Sleep Advisor, our editorial team utilizes reputable sources and expert feedback to provide well-researched sleep health content. For more details, read our full [editorial policy](https://www.sleepadvisor.org/editorial-policy/).
### In This Article
Discover comprehensive information about the safety and potential side effects of melatonin, along with additional tips and insights.
Melatonin is a hormone that we all naturally produce. Its production [increases when it is dark](https://www.ncbi.nlm.nih.gov/books/NBK550972/)1, signaling to our bodies that it is time to get sleepy, and it decreases when it becomes light, signaling to our bodies it is time to wake up.
Melatonin supplements, on the other hand, are often created synthetically, and you can take them in the form of capsules, tablets, liquids, gummies, [or even patches](https://www.ncbi.nlm.nih.gov/books/NBK534823/)2. These are used to [help people sleep](https://www.hopkinsmedicine.org/health/wellness-and-prevention/melatonin-for-sleep-does-it-work)3 by helping to regulate their [circadian rhythm](https://www.sleepadvisor.org/what-is-circadian-rhythm/), the body’s natural sleep-wake cycle.
Melatonin is generally considered safe to take on a temporary basis, especially if people find it beneficial.1 However, that doesn’t mean it can’t have side effects.
**Read Our Guide:** [Melatonin: Everything You Should Know](https://www.sleepadvisor.org/melatonin/)
## Side Effects of Melatonin
Experts consider occasional or short-term melatonin use to be safe for most people, and the risk of side effects is low.2, 3
That said, there are [possible side effects](https://www.nhs.uk/medicines/melatonin/side-effects-of-melatonin/)4 that can happen when taking melatonin.
- **Daytime fatigue** – The most common side effect of melatonin is fatigue in the morning after taking it.4 If this happens to you, try lowering your dose and making sure you’re taking it two hours before bed.3
- **Headache** – Melatonin may cause a headache in some people. To combat this, England’s National Health Service (NHS) recommends drinking plenty of water if you’re taking melatonin. They also advise avoiding alcohol because it can make you dehydrated and impact the way melatonin works.4
- **Stomach issues** – Some people report stomach aches or nausea when using melatonin.4 That said, some research has shown that melatonin may help with IBS due to its slight pain-relieving effects.2 Additionally, its ability to regulate the [circadian rhythms of our gut bacteria](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959415/)5 could be helpful as well.
- **Dizziness** – The NHS recommends avoiding driving, cycling, or using any tools or machinery if melatonin has made you dizzy. Additionally, alcohol can worsen your dizziness, so avoid mixing melatonin and alcohol.4
- **Irritability** – Some people report irritability or restlessness when taking melatonin.4 If this happens to you, it may very well be because you’re taking too high a dose.2 Try lowering your dose, and if this doesn’t work, stop taking melatonin.
- **More vivid or strange dreams** – According to the NHS, taking melatonin may lead to more strange dreams.4 Supplemental melatonin can increase the [amount of time spent in REM sleep](https://health.clevelandclinic.org/does-melatonin-cause-bad-dreams)6, which is the portion of our sleep cycle when vivid dreams are more likely to occur. This means you could be more likely to dream since you’re in REM sleep longer, however, experts say it’s not clear whether melatonin directly causes more vivid dreaming.6
**Melatonin may also interact with other medications and/or supplements, so we encourage anyone considering melatonin to contact their healthcare provider first.**
### Side Effects of Melatonin in Children
Supplemental melatonin is generally considered [safe for kids](https://answers.childrenshospital.org/melatonin-for-children/)7 as long as the dose is appropriate and any behavioral or environmental issues impacting sleep are also addressed. However, melatonin may affect children differently than adults.
For example, experts say that melatonin production [declines at the onset of puberty](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/)8.
Since this drop in melatonin is a natural process before puberty, some experts hypothesize that giving your prepubescent child melatonin could delay puberty, though more research is needed to confirm this.8
Children may also be more susceptible to nightmares and vivid dreams with melatonin supplements. Kids naturally [spend more time in REM sleep](https://kidshealth.org/en/parents/sleep.html)9, and as mentioned, taking supplemental melatonin seems to increase the time spent in REM sleep, which is when vivid dreams and nightmares often occur.6
Other side effects for children taking melatonin are similar to those of adults: headaches, dizziness, mood changes, and morning grogginess.7 These side effects should disappear with discontinuation.
It’s also important to note that most of the research done on children and melatonin is in kids with ADHD rather than kids without attention disorders. Therefore, more research is needed.
**Learn more**: [A Guide to Melatonin for Kids](https://www.sleepadvisor.org/melatonin-for-kids/)
## Melatonin Safety
****Before taking any new supplements or altering your current dose, we strongly encourage you to consult your healthcare provider.****
When taking melatonin it is important to remember that more is not alwaysbetter. Some experts advise taking 1 to 3 milligrams two hours before bed.3 That said, this dosage is a general recommendation, and you should discuss dosage with your healthcare provider to ensure you take the proper amount for you.
Melatonin timing is important because two hours before bedtime is about when your body naturally starts producing melatonin in the absence of artificial light.1 So to help maximize its effectiveness, you’ll also want to dim the lights and stop looking at screens at about this time.3
If lowering the dose and taking it earlier does not mitigate your side effects, you can stop taking melatonin at any time without worrying about [weaning off of it](https://health.clevelandclinic.org/melatonin-dependency)10. Unlike other sleep medications where you need to take more of it over time or experience a “hangover” effect in the morning, melatonin is considered to be [non-addictive or habit-forming from a physiological standpoint](https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/melatonin-side-effects/faq-20057874)11.
However, it’s important to note that because melatonin is sold as a dietary supplement in the United States, it is not as strictly regulated by the Food and Drug Administration (FDA) as prescription medications. This means that when you buy your melatonin supplement, you’ll have no real way of knowing how much melatonin (or other ingredients) are actually in the supplement unless the brand does third-party testing, which is not industry standard at the moment unfortunately.2
This is why it is important to buy a melatonin supplement from a high-quality, reputable brand. For example, look for supplements approved by the [U.S. Pharmacopeia](https://www.ncbi.nlm.nih.gov/books/NBK218324/)12, a third-party organization that helps provide product transparency for consumers. You can look for the words “USP verified” on the label.
### Who Should Avoid Melatonin?
Although this supplement is generally considered safe, certain populations should [avoid taking melatonin](https://www.nhs.uk/medicines/melatonin/who-can-and-cannot-take-melatonin/)13.
- **Those who have a melatonin allergy** – If you’ve ever had an allergic reaction to a supplement containing melatonin or any other medication, you should not take melatonin.13
- **Those with liver or kidney problems** – The National Health Service advises against taking melatonin for those with liver or kidney problems.13 However, there has been research looking at melatonin’s role in potentially [healing the liver](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412268/)14 and [kidneys](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047594/)15, so more information is needed.
- **Those taking medications that could interact** – Melatonin may interact with certain medications, potentially impacting their efficacy. According to the [Mayo Clinic](https://www.mayoclinic.org/drugs-supplements-melatonin/art-20363071)16, these include drugs for blood clots, seizures, blood pressure, the central nervous system, diabetes, and contraception — among others.
- **People with autoimmune disorders** – If you have lupus, multiple sclerosis, rheumatoid arthritis, or any other autoimmune condition, you should avoid supplemental melatonin as it may stimulate inflammation.13
### Can You Overdose on Melatonin?
Let’s quickly clarify the difference between an overdose and a lethal dose. [An overdose](https://www.betterhealth.vic.gov.au/health/healthyliving/drug-overdose)17 means you’ve taken too much of something (a “toxic” amount) and are experiencing side effects as a result. A lethal dose means you have taken so much of something that it kills you.
You can overdose on melatonin, meaning you can take too much of it and experience side effects. The most common [side effects of a melatonin overdose](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9567778/)18 are drowsiness, dizziness, headache, fatigue, confusion, bad dreams, hypothermia, tachycardia, and hypotension.
**Learn more:** Can You [Overdose on Melatonin?](https://www.sleepadvisor.org/can-you-overdose-on-melatonin/)
### When Should You Seek Medical Help?
More serious melatonin side effects are rare, affecting less than 1 in 1,000 people. That said, if after taking melatonin you experience changes in your eyesight, feel faint or pass out, start feeling confused, experience vertigo, or have unexplained bruising or bleeding that does not stop, you should discontinue use and call your healthcare provider or 911.4
In very rare cases, it is possible to have a **serious allergic reaction to melatonin**, which includes symptoms such as4:
- Sudden swelling of the lips, tongue, mouth, or throat
- Struggling to breathe
- Inability to swallow
- The skin, tongue, or lips suddenly turn blue, gray, or pale
- A skin rash that is swollen, itchy, blistered, or peeling
- Sudden confusion, dizziness, or drowsiness
- Fainting and not waking up
- A child going limp, floppy, or not responding as they normally do
If any of these symptoms of an allergic reaction occur after taking melatonin, you should discontinue use and seek emergency medical care.
## Additional Sleep Tips
If you either can’t or would prefer not to take melatonin, there are other ways to [get better sleep](https://www.sleepadvisor.org/how-to-get-better-sleep/) through daily sleep hygiene habits. Many of these can also complement the effects of melatonin supplementation.
- **Increase your melatonin naturally** – You can help your body’s natural melatonin production by dimming the lights at night and cutting off screen devices like smartphones and laptops at least one hour before bed.1 You can also eat more [melatonin-boosting foods](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409706/)19 like eggs, fish, nuts, seeds, legumes, mushrooms, and certain cereals.
- **Establish a regular sleep schedule** – Going to bed and waking up at the same time each day can help regulate your circadian rhythm and get your sleep schedule back on track.
- **Practice a nightly routine** – Introducing a regular, relaxing nighttime routine can help you wind down before bed and tell your body it’s time to rest. Some great examples of nighttime rituals are baths, reading a book, journaling, meditation, or gentle stretching.
- **Create an ideal sleep environment** – [Your bedroom](https://www.sleepadvisor.org/sleep-enviroment/) should be dark to promote melatonin production. However, keeping it cool and quiet can also foster better sleep. Additionally, sleeping on a [quality mattress](https://www.sleepadvisor.org/best-mattress/) and comfortable bedding can help you feel even more ready for sleep.
- **Avoid alcohol at night** – Research shows that [alcohol negatively impacts sleep](https://pubmed.ncbi.nlm.nih.gov/31128400/)20. Therefore, avoid consuming alcohol at night if you’re having sleep issues.
- **Stop drinking caffeine in the afternoon** – You should have your last cup of coffee at least [six hours](https://www.houstonmethodist.org/blog/articles/2021/oct/caffeine-sleep-how-long-does-caffeine-keep-you-awake/)21 before you plan to go to bed since caffeine can stay in your system for up to six hours.
- **Avoid large meals at night** – Eating a big meal late at night could negatively impact your sleep, possibly causing discomfort or indigestion. Research shows that eating [three hours](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215804/)22 or more before bed is ideal.
- **Add in regular exercise** – Regular exercise [has been proven](https://www.hopkinsmedicine.org/health/wellness-and-prevention/exercising-for-better-sleep)23 to help you fall asleep more quickly and improve overall sleep quality.
- **Limit afternoon naps** – Afternoon naps can impact your ability to fall asleep at night. If you do need to take a nap, limit it to [10 to 20 minutes](https://www.mayoclinic.org/healthy-lifestyle/adult-health/in-depth/napping/art-20048319)24 so it won’t negatively impact your sleep that night.
- **Try magnesium instead** – Certain types of [magnesium supplements](https://www.sleepadvisor.org/best-magnesium-for-sleep/) may help with sleep. Just like with melatonin, speak with your healthcare provider before introducing any to your daily routine.
**Learn more:** [Magnesium vs. Melatonin](https://www.sleepadvisor.org/magnesium-vs-melatonin/)
## Frequently Asked Questions |
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