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| Boilerpipe Text | Donald Trump speaks at a campaign rally Wednesday in Duluth, Ga. His bizarre behavior, delusional claims and visions of grandeur could be attributed to mental decline.
Anna Moneymaker/Getty Images
Concerns about Donald Trumpâs mental fitness have heightened since his latest
refusal to release his medical records
to the public.
Reports
from some of his closest associates over the past eight years have noted a marked decline in his ability to remain on topic and his fanciful rambling.
Facts have become confused
, threats have been made and a sense of grandiosity, mixed with paranoia, prevails.
His behavior may be all a calculated, contrived act to win the presidential election. If not, then there is some serious pathology going on here.
I have practiced internal medicine for 45 years, and it is not uncommon for family or friends to bring me someone who is beginning to mentally unravel. My job is to figure out what, among the multiple plausible causes, is contributing to the patientâs deterioration, and what, if anything, I can do to improve the situation.
Article continues below this ad
Although I cannot definitively assess Trumpâs cognitive functioning without examining him in person, physicians regularly explore the potential causes of a patientâs illness as part of a time-honored tradition during what we call âGrand Rounds.â
More Opinions
In this format, a patient case is presented, and a senior clinician discusses the probable causes of the patientâs ailment, known as a âdifferential diagnosis.â The senior clinician has never seen the patient and admits to only receiving information secondhand. Therefore, a best guess is all that can be offered in a differential diagnosis of multiple diseases.Â
San Francisco Chronicle Logo
Make us a Preferred Source to get more of our news when you search.
Add Preferred Source
While physicians rightfully continue to genuflect to the
Goldwater Rule
 â the idea that a specific diagnosis requires a personal examination â the concept does not extend to a reasonable inquiry by physicians offering a differential diagnosis, as done during Grand Rounds.
Article continues below this ad
In Trumpâs case, the differential of cognitive decline is extensive.
Alzheimerâs disease, for example, could be at play but also a host of other medical conditions could be causing his symptoms, including poor blood flow to the brain due to hardening of the arteries, vitamin B12 deficiency, low thyroid function, mercury and other heavy metal ingestion, diffuse tumors such as lymphoma, and infection, to name a few.
Most of these disorders are detected readily with simple blood tests and a physical exam. But there is one disease, if not thought about, might slip by, with devastating consequences: syphilis.
Neurosyphilis is an infection of the brain by an infectious agent called a spirochete.
Brain damage due to syphilis is a rare but fatal disease if not treated. It begins with a small sore on the genitals that is not painful and goes away on its own. However, the spirochete, if not diagnosed and treated appropriately, can continue to spread throughout the body. A secondary phase, associated with a rash, lymph node swelling, and fatigue can occur a few weeks to months later, but that too can resolve on its own. The disease, however, is relentless and can remain dormant for 25 years before reemerging as cognitive impairment. Patients with neurosyphilis have often been confused with having other types of dementia. For this reason, it has gained the moniker
the Great Imitator
.
Article continues below this ad
When syphilis affects the brain, it is a progressive dementing illness. In addition to memory loss, the symptoms include impaired judgment, uninhibited speech and actions, delusions, confusion, paranoia and grandiose thoughts. The most common blood test for the disease can be negative after so many years, and the only way to confirm the diagnosis is to perform a spinal tap to evaluate the fluid around the brain.
Not exactly a routine procedure for an annual physical exam.
The spirochete has a predilection to attack the frontal lobe of the brain â the area of the brain responsible for our judgment and inhibition. It helps us filter our thoughts and not just pop off with anything that comes to mind, no matter how inappropriate. Recent events, such as TrumpâsÂ
vulgar behavior at the Al Smith dinner
, his bizarre
39-minute break to listen to a playlist
rather than address the audience, and especially his
reference to Arnold Palmerâs genitalia
, are a clear sign the frontal lobe is not doing its job.
Trumpâs
insistence that he won the 2020 presidential election
seems delusional. Believing that heads of state will bow to his personality and charm is a sign of grandiosity and
threats to prosecute his adversaries
demonstrates paranoia. Meandering speeches about
sharks
and
cannibals
,
disorientation to what state he is in
 and disassembled facts that blur the difference between truth and fiction are further, but nonspecific, signs of mental decay.  Â
Again, without a personal exam, I am unable to make a specific diagnosis of Trumpâs cognitive decline. I must rely on his public remarks and behaviors to guide my analysis. What is clear though, is something is not right.
Article continues below this ad
We do not know what blood tests the former president has taken, but even if his doctors rule out most possible causes for his mental decline, The Great Imposter needs to be ruled out as well.
Unlike most causes of dementia, syphilis is treatable. Since the 1950s, penicillin has been recognized as halting the progression of the disease in some cases.
About Opinion
Guest opinions in
Open Forum and Insight
are produced by writers with expertise, personal experience or original insights on a subject of interest to our readers.
Their views do not necessarily reflect
the opinion of The Chronicle editorial board, which is committed to providing a diversity of ideas to our readership.
Before assuming the most powerful position in the world, Trump needs a thorough exam by a neurologist and a qualified infectious disease specialist.
If you do not believe me, ask your doctor, âIs syphilis in the differential?â
Article continues below this ad
Dr. William Andereck is a bioethicist and internist in private practice in San Francisco. Â | |||||||||||||||
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# Trumpâs mental decline could be caused by many possible factors. One may not show up on a blood test
By William Andereck
Oct 27, 2024
![Donald Trump speaks at a campaign rally Wednesday in Duluth, Ga. His bizarre behavior, delusional claims and visions of grandeur could be attributed to mental decline.]()
Donald Trump speaks at a campaign rally Wednesday in Duluth, Ga. His bizarre behavior, delusional claims and visions of grandeur could be attributed to mental decline.
Anna Moneymaker/Getty Images
Concerns about Donald Trumpâs mental fitness have heightened since his latest [refusal to release his medical records](https://www.cnbc.com/2024/10/18/trump-health-records-harris-exhausted.html) to the public. [Reports](https://www.politico.com/story/2018/08/12/omarosa-trump-mental-state-book-kelly-773889) from some of his closest associates over the past eight years have noted a marked decline in his ability to remain on topic and his fanciful rambling. [Facts have become confused](https://www.nytimes.com/2024/10/06/us/politics/trump-speeches-age-cognitive-decline.html), threats have been made and a sense of grandiosity, mixed with paranoia, prevails.
His behavior may be all a calculated, contrived act to win the presidential election. If not, then there is some serious pathology going on here.
I have practiced internal medicine for 45 years, and it is not uncommon for family or friends to bring me someone who is beginning to mentally unravel. My job is to figure out what, among the multiple plausible causes, is contributing to the patientâs deterioration, and what, if anything, I can do to improve the situation.
Advertisement
Article continues below this ad
Although I cannot definitively assess Trumpâs cognitive functioning without examining him in person, physicians regularly explore the potential causes of a patientâs illness as part of a time-honored tradition during what we call âGrand Rounds.â
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In this format, a patient case is presented, and a senior clinician discusses the probable causes of the patientâs ailment, known as a âdifferential diagnosis.â The senior clinician has never seen the patient and admits to only receiving information secondhand. Therefore, a best guess is all that can be offered in a differential diagnosis of multiple diseases.
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While physicians rightfully continue to genuflect to the [Goldwater Rule](https://www.sfchronicle.com/opinion/openforum/article/trump-mental-health-19821030.php) â the idea that a specific diagnosis requires a personal examination â the concept does not extend to a reasonable inquiry by physicians offering a differential diagnosis, as done during Grand Rounds.
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Article continues below this ad
In Trumpâs case, the differential of cognitive decline is extensive.
Alzheimerâs disease, for example, could be at play but also a host of other medical conditions could be causing his symptoms, including poor blood flow to the brain due to hardening of the arteries, vitamin B12 deficiency, low thyroid function, mercury and other heavy metal ingestion, diffuse tumors such as lymphoma, and infection, to name a few.
Most of these disorders are detected readily with simple blood tests and a physical exam. But there is one disease, if not thought about, might slip by, with devastating consequences: syphilis.
Neurosyphilis is an infection of the brain by an infectious agent called a spirochete.
Brain damage due to syphilis is a rare but fatal disease if not treated. It begins with a small sore on the genitals that is not painful and goes away on its own. However, the spirochete, if not diagnosed and treated appropriately, can continue to spread throughout the body. A secondary phase, associated with a rash, lymph node swelling, and fatigue can occur a few weeks to months later, but that too can resolve on its own. The disease, however, is relentless and can remain dormant for 25 years before reemerging as cognitive impairment. Patients with neurosyphilis have often been confused with having other types of dementia. For this reason, it has gained the moniker [the Great Imitator](https://pmc.ncbi.nlm.nih.gov/articles/PMC9859468/).
Advertisement
Article continues below this ad
When syphilis affects the brain, it is a progressive dementing illness. In addition to memory loss, the symptoms include impaired judgment, uninhibited speech and actions, delusions, confusion, paranoia and grandiose thoughts. The most common blood test for the disease can be negative after so many years, and the only way to confirm the diagnosis is to perform a spinal tap to evaluate the fluid around the brain.
Not exactly a routine procedure for an annual physical exam.
The spirochete has a predilection to attack the frontal lobe of the brain â the area of the brain responsible for our judgment and inhibition. It helps us filter our thoughts and not just pop off with anything that comes to mind, no matter how inappropriate. Recent events, such as Trumpâs [vulgar behavior at the Al Smith dinner](https://www.washingtonpost.com/politics/2024/10/17/trump-harris-al-smith-dinner/), his bizarre [39-minute break to listen to a playlist](https://www.washingtonpost.com/politics/2024/10/14/trump-music-sways-town-hall/) rather than address the audience, and especially his [reference to Arnold Palmerâs genitalia](https://www.sfchronicle.com/opinion/openforum/article/trump-arnold-palmer-19852844.php), are a clear sign the frontal lobe is not doing its job.
Trumpâs [insistence that he won the 2020 presidential election](https://www.politico.com/news/2024/09/10/trump-harris-debate-2020-fiction-00178511) seems delusional. Believing that heads of state will bow to his personality and charm is a sign of grandiosity and [threats to prosecute his adversaries](https://www.npr.org/2024/10/21/nx-s1-5134924/trump-election-2024-kamala-harris-elizabeth-cheney-threat-civil-liberties) demonstrates paranoia. Meandering speeches about [sharks](https://www.washingtonpost.com/politics/2024/07/26/trump-shark-ev-boat-electrocution/) and [cannibals](https://www.washingtonpost.com/politics/2024/08/14/why-trump-keeps-talking-about-fictional-serial-killer-hannibal-lecter/), [disorientation to what state he is in](https://www.newsweek.com/donald-trump-confusing-state-hes-raises-questions-1940779) and disassembled facts that blur the difference between truth and fiction are further, but nonspecific, signs of mental decay.
Again, without a personal exam, I am unable to make a specific diagnosis of Trumpâs cognitive decline. I must rely on his public remarks and behaviors to guide my analysis. What is clear though, is something is not right.
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Article continues below this ad
We do not know what blood tests the former president has taken, but even if his doctors rule out most possible causes for his mental decline, The Great Imposter needs to be ruled out as well.
Unlike most causes of dementia, syphilis is treatable. Since the 1950s, penicillin has been recognized as halting the progression of the disease in some cases.
About Opinion
Guest opinions in **Open Forum and Insight** are produced by writers with expertise, personal experience or original insights on a subject of interest to our readers. **Their views do not necessarily reflect** the opinion of The Chronicle editorial board, which is committed to providing a diversity of ideas to our readership.
[*Read more about our transparency and ethics policies*](https://www.sfchronicle.com/standards/)
Before assuming the most powerful position in the world, Trump needs a thorough exam by a neurologist and a qualified infectious disease specialist.
If you do not believe me, ask your doctor, âIs syphilis in the differential?â
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*Dr. William Andereck is a bioethicist and internist in private practice in San Francisco.*
Oct 27, 2024
William Andereck
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| Readable Markdown | ![Donald Trump speaks at a campaign rally Wednesday in Duluth, Ga. His bizarre behavior, delusional claims and visions of grandeur could be attributed to mental decline.]()
Donald Trump speaks at a campaign rally Wednesday in Duluth, Ga. His bizarre behavior, delusional claims and visions of grandeur could be attributed to mental decline.
Anna Moneymaker/Getty Images
Concerns about Donald Trumpâs mental fitness have heightened since his latest [refusal to release his medical records](https://www.cnbc.com/2024/10/18/trump-health-records-harris-exhausted.html) to the public. [Reports](https://www.politico.com/story/2018/08/12/omarosa-trump-mental-state-book-kelly-773889) from some of his closest associates over the past eight years have noted a marked decline in his ability to remain on topic and his fanciful rambling. [Facts have become confused](https://www.nytimes.com/2024/10/06/us/politics/trump-speeches-age-cognitive-decline.html), threats have been made and a sense of grandiosity, mixed with paranoia, prevails.
His behavior may be all a calculated, contrived act to win the presidential election. If not, then there is some serious pathology going on here.
I have practiced internal medicine for 45 years, and it is not uncommon for family or friends to bring me someone who is beginning to mentally unravel. My job is to figure out what, among the multiple plausible causes, is contributing to the patientâs deterioration, and what, if anything, I can do to improve the situation.
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Although I cannot definitively assess Trumpâs cognitive functioning without examining him in person, physicians regularly explore the potential causes of a patientâs illness as part of a time-honored tradition during what we call âGrand Rounds.â
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In this format, a patient case is presented, and a senior clinician discusses the probable causes of the patientâs ailment, known as a âdifferential diagnosis.â The senior clinician has never seen the patient and admits to only receiving information secondhand. Therefore, a best guess is all that can be offered in a differential diagnosis of multiple diseases.
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While physicians rightfully continue to genuflect to the [Goldwater Rule](https://www.sfchronicle.com/opinion/openforum/article/trump-mental-health-19821030.php) â the idea that a specific diagnosis requires a personal examination â the concept does not extend to a reasonable inquiry by physicians offering a differential diagnosis, as done during Grand Rounds.
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In Trumpâs case, the differential of cognitive decline is extensive.
Alzheimerâs disease, for example, could be at play but also a host of other medical conditions could be causing his symptoms, including poor blood flow to the brain due to hardening of the arteries, vitamin B12 deficiency, low thyroid function, mercury and other heavy metal ingestion, diffuse tumors such as lymphoma, and infection, to name a few.
Most of these disorders are detected readily with simple blood tests and a physical exam. But there is one disease, if not thought about, might slip by, with devastating consequences: syphilis.
Neurosyphilis is an infection of the brain by an infectious agent called a spirochete.
Brain damage due to syphilis is a rare but fatal disease if not treated. It begins with a small sore on the genitals that is not painful and goes away on its own. However, the spirochete, if not diagnosed and treated appropriately, can continue to spread throughout the body. A secondary phase, associated with a rash, lymph node swelling, and fatigue can occur a few weeks to months later, but that too can resolve on its own. The disease, however, is relentless and can remain dormant for 25 years before reemerging as cognitive impairment. Patients with neurosyphilis have often been confused with having other types of dementia. For this reason, it has gained the moniker [the Great Imitator](https://pmc.ncbi.nlm.nih.gov/articles/PMC9859468/).
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When syphilis affects the brain, it is a progressive dementing illness. In addition to memory loss, the symptoms include impaired judgment, uninhibited speech and actions, delusions, confusion, paranoia and grandiose thoughts. The most common blood test for the disease can be negative after so many years, and the only way to confirm the diagnosis is to perform a spinal tap to evaluate the fluid around the brain.
Not exactly a routine procedure for an annual physical exam.
The spirochete has a predilection to attack the frontal lobe of the brain â the area of the brain responsible for our judgment and inhibition. It helps us filter our thoughts and not just pop off with anything that comes to mind, no matter how inappropriate. Recent events, such as Trumpâs [vulgar behavior at the Al Smith dinner](https://www.washingtonpost.com/politics/2024/10/17/trump-harris-al-smith-dinner/), his bizarre [39-minute break to listen to a playlist](https://www.washingtonpost.com/politics/2024/10/14/trump-music-sways-town-hall/) rather than address the audience, and especially his [reference to Arnold Palmerâs genitalia](https://www.sfchronicle.com/opinion/openforum/article/trump-arnold-palmer-19852844.php), are a clear sign the frontal lobe is not doing its job.
Trumpâs [insistence that he won the 2020 presidential election](https://www.politico.com/news/2024/09/10/trump-harris-debate-2020-fiction-00178511) seems delusional. Believing that heads of state will bow to his personality and charm is a sign of grandiosity and [threats to prosecute his adversaries](https://www.npr.org/2024/10/21/nx-s1-5134924/trump-election-2024-kamala-harris-elizabeth-cheney-threat-civil-liberties) demonstrates paranoia. Meandering speeches about [sharks](https://www.washingtonpost.com/politics/2024/07/26/trump-shark-ev-boat-electrocution/) and [cannibals](https://www.washingtonpost.com/politics/2024/08/14/why-trump-keeps-talking-about-fictional-serial-killer-hannibal-lecter/), [disorientation to what state he is in](https://www.newsweek.com/donald-trump-confusing-state-hes-raises-questions-1940779) and disassembled facts that blur the difference between truth and fiction are further, but nonspecific, signs of mental decay.
Again, without a personal exam, I am unable to make a specific diagnosis of Trumpâs cognitive decline. I must rely on his public remarks and behaviors to guide my analysis. What is clear though, is something is not right.
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We do not know what blood tests the former president has taken, but even if his doctors rule out most possible causes for his mental decline, The Great Imposter needs to be ruled out as well.
Unlike most causes of dementia, syphilis is treatable. Since the 1950s, penicillin has been recognized as halting the progression of the disease in some cases.
About Opinion
Guest opinions in **Open Forum and Insight** are produced by writers with expertise, personal experience or original insights on a subject of interest to our readers. **Their views do not necessarily reflect** the opinion of The Chronicle editorial board, which is committed to providing a diversity of ideas to our readership.
Before assuming the most powerful position in the world, Trump needs a thorough exam by a neurologist and a qualified infectious disease specialist.
If you do not believe me, ask your doctor, âIs syphilis in the differential?â
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*Dr. William Andereck is a bioethicist and internist in private practice in San Francisco.* | |||||||||||||||
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