🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 71 (from laksa100)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa071.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.phillyvoice.com/covid-brain-fog-cause-coronavirus-long-haulers-symptoms/\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.phillyvoice.com/covid-brain-fog-cause-coronavirus-long-haulers-symptoms/\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.phillyvoice.com\/covid-brain-fog-cause-coronavirus-long-haulers-symptoms\/","crawl_time":1775802647,"first_indexed_time":1614994518,"http_code":200,"src_unparsed":"com,phillyvoice!www,\/covid-brain-fog-cause-coronavirus-long-haulers-symptoms\/ s443","src_root_hash":"11344392671752789071","history_drop_reason":null,"meta_title":"Scientists gain new insights into the cause of 'COVID brain' | PhillyVoice","meta_descriptions":["Researchers are getting closer to understanding why some people experience brain fog after recovering from COVID-19. Two studies offer new insights into why some people suffer confusion, short-term memory loss or severe delirium after a coronavirus infection."],"attrs_boilerpipe_text":"Scientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19. \nThe symptom is common among so-called \"long-haulers\" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists. \nMORE HEALTH\nPennsylvania to establish COVID-19 vaccine sites for teachers, school staffers\nFEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot\nThe immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say\nBrain fog has taken\n the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium. \nThe symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as \"COVID brain.\" The medical term for it is \nencephalopathy.\nThe cause of this lingering symptom is becoming more clear thanks to two small studies.\nOne study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found.\n\"To have megakaryocytes in the brain has never been seen before,\" Dr. David Nauen, a pathologist at John Hopkins University who led the study, told\nABC News\n. \"\nI couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this.\"\nResearchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a \"significant\" amount of \nmegakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly. \nThe study's results were published last month\n in the\nJournal of the American Medical Association\n. \nAnother study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain.  \nThe study, published in the journal \nCancer Cell\n, sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. \nThe researchers analyzed the brain scans and electroencephalogram results of 18 patients. \n\"We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having,\"\nsaid\n Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City. \nThe response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said. \n\"We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system,\" \nsaid\n Dr. Adrienne Boire, another researcher involved with the study. \"But the more we look, the more we find connections between the two.\"\nCAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms. ","attrs_markdown":"- [![Limited - Haven Harbour Cottage](https:\/\/media.phillyvoice.com\/media\/images\/Haven_Harbour_Cottage.2e16d0ba.fill-220x140.jpg) Kent County: a top Chesapeake escape](https:\/\/www.phillyvoice.com\/why-kent-county-is-one-of-the-chesapeake-bays-best-summer-escapes-05999-64829\/)\n- [![Purchased - Man holding blue ribbon supporting colon cancer awareness](https:\/\/media.phillyvoice.com\/media\/images\/iStock-2212351683.2e16d0ba.fill-220x140.jpg) Colon cancer: Rising in young adults](https:\/\/www.phillyvoice.com\/colon-cancer-rising-young-adults-md-anderson-cooper-0599935\/)\n- [![Limited - Hopkins Brewery](https:\/\/media.phillyvoice.com\/media\/images\/HelloHarford_PhillyVoice_April2026.2e16d0ba.fill-220x140.jpg) Harford County spring blooms & festivals](https:\/\/www.phillyvoice.com\/spring-harford-county-brings-festivals-blooms-and-waterfront-views-05999-147\/)\n- [![Friends with advice, talking and understanding in living room](https:\/\/media.phillyvoice.com\/media\/images\/iStock-2205927458.2e16d0ba.fill-220x140.jpg) Recognizing a substance use disorder](https:\/\/www.phillyvoice.com\/recognizing-signs-substance-use-disorder-059991\/)\n\n[Menu](https:\/\/www.phillyvoice.com\/covid-brain-fog-cause-coronavirus-long-haulers-symptoms\/)  [![](https:\/\/media.phillyvoice.com\/static\/global\/images\/AHealthierPhilly1x.png)](https:\/\/www.phillyvoice.com\/health\/)\n\n[PhillyVoice](https:\/\/www.phillyvoice.com\/)\n\n- [News](https:\/\/www.phillyvoice.com\/news\/)\n  - [Politics](https:\/\/www.phillyvoice.com\/tags\/politics\/)\n  - [Opinion](https:\/\/www.phillyvoice.com\/tags\/opinion\/)\n  - [Crime](https:\/\/www.phillyvoice.com\/tags\/crime\/)\n  - [Odd News](https:\/\/www.phillyvoice.com\/tags\/odd-news\/)\n  - [Education](https:\/\/www.phillyvoice.com\/tags\/education\/)\n  - [Business](https:\/\/www.phillyvoice.com\/tags\/business\/)\n- [Health](https:\/\/www.phillyvoice.com\/health\/)\n  - [Health News](https:\/\/www.phillyvoice.com\/tags\/health-news\/)\n  - [Illness](https:\/\/www.phillyvoice.com\/tags\/illness\/)\n  - [Children's Health](https:\/\/www.phillyvoice.com\/tags\/childrens-health\/)\n  - [Addiction](https:\/\/www.phillyvoice.com\/tags\/addiction\/)\n  - [Fitness](https:\/\/www.phillyvoice.com\/tags\/fitness\/)\n  - [Wellness](https:\/\/www.phillyvoice.com\/tags\/wellness\/)\n  - [Parenting](https:\/\/www.phillyvoice.com\/tags\/parenting\/)\n- [Culture](https:\/\/www.phillyvoice.com\/culture\/)\n  - [Food & Drink](https:\/\/www.phillyvoice.com\/tags\/food-drink\/)\n  - [TV](https:\/\/www.phillyvoice.com\/tags\/tv\/)\n  - [Music](https:\/\/www.phillyvoice.com\/tags\/music\/)\n  - [Entertainment](https:\/\/www.phillyvoice.com\/tags\/entertainment\/)\n  - [Arts & Culture](https:\/\/www.phillyvoice.com\/tags\/arts-culture\/)\n  - [Pets](https:\/\/www.phillyvoice.com\/tags\/pets\/)\n- [Events](https:\/\/www.phillyvoice.com\/events\/)\n  - [Fitness](https:\/\/www.phillyvoice.com\/tags\/fitness\/)\n  - [Family-Friendly](https:\/\/www.phillyvoice.com\/tags\/family-friendly\/)\n  - [Festivals](https:\/\/www.phillyvoice.com\/tags\/festivals\/)\n  - [Performances](https:\/\/www.phillyvoice.com\/tags\/performances\/)\n  - [Food & Drink](https:\/\/www.phillyvoice.com\/tags\/food-drink\/)\n  - [Shopping](https:\/\/www.phillyvoice.com\/tags\/shopping\/)\n- [Sports](https:\/\/www.phillyvoice.com\/sports\/)\n  - [Eagles](https:\/\/www.phillyvoice.com\/tags\/eagles\/)\n  - [Sixers](https:\/\/www.phillyvoice.com\/tags\/sixers\/)\n  - [Phillies](https:\/\/www.phillyvoice.com\/tags\/phillies\/)\n  - [Flyers](https:\/\/www.phillyvoice.com\/tags\/flyers\/)\n  - [Fantasy Football](https:\/\/www.phillyvoice.com\/tags\/fantasy-football\/)\n- [Staff \/ Contributors](https:\/\/www.phillyvoice.com\/staff-contributors)\n- [Company Info](https:\/\/www.phillyvoice.com\/covid-brain-fog-cause-coronavirus-long-haulers-symptoms\/)\n  - [About Us](https:\/\/www.phillyvoice.com\/about-us\/)\n  - [Advertise](https:\/\/www.phillyvoicemedia.com\/)\n  - [Contact Us](https:\/\/www.phillyvoice.com\/contact-us\/)\n  - [Legal \/ Privacy](https:\/\/www.phillyvoice.com\/legal-privacy-ethics\/)\n  - [Staff \/ Contributors](https:\/\/www.phillyvoice.com\/staff-contributors\/)\n  - [RSS](https:\/\/www.phillyvoice.com\/rss-feeds\/)\n\n© 2026 WWB Holdings, LLC. All rights reserved\n\n### More Health:\n- [Health News](https:\/\/www.phillyvoice.com\/tags\/health-news\/)\n- [Parenting](https:\/\/www.phillyvoice.com\/tags\/parenting\/)\n- [Wellness](https:\/\/www.phillyvoice.com\/tags\/wellness\/)\n- [Healthy Eating](https:\/\/www.phillyvoice.com\/tags\/healthy-eating\/)\n- [Mental Health](https:\/\/www.phillyvoice.com\/tags\/mental-health\/)\n- [Addiction](https:\/\/www.phillyvoice.com\/tags\/addiction\/)\n- [Newsletters](https:\/\/www.phillyvoice.com\/newsletters\/)\n\nMarch 05, 2021\n\n# Scientists zeroing in on the cause of 'COVID brain'\n## Some people experience confusion, short-term memory loss or difficulty concentrating months after recovering from the coronavirus\n![Allie Miller Headshot](https:\/\/media.phillyvoice.com\/media\/images\/012920-Allie-Miller-Headshot-300x.5bc9f099.fill-54x45-c0.jpg)\n\nBy  [Allie Miller](https:\/\/www.phillyvoice.com\/staff-contributors\/allie-miller\/)    \n  PhillyVoice Staff\n\n[Adult Health](https:\/\/www.phillyvoice.com\/tags\/adult-health\/) [COVID-19](https:\/\/www.phillyvoice.com\/tags\/covid-19\/)\n\nfrom  [![IBC-Logo-125x21](https:\/\/media.phillyvoice.com\/media\/images\/IBC-300-PNG24-101725-04.max-125x32.png)](https:\/\/www.ibx.com\/)\n\n![brain fog coronavirus](https:\/\/media.phillyvoice.com\/media\/images\/030521_COVID_Brain_Fog.2e16d0ba.fill-735x490.jpg)  Dylan Ferreira\/Unsplash.com\n\nNew research offers insights into the reason some people experience neurological symptoms, like short-term memory loss and confusion, months after recovering from COVID-19.\n\n[Read More](https:\/\/www.phillyvoice.com\/covid-brain-fog-cause-coronavirus-long-haulers-symptoms\/)\n\nScientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19.\n\nThe symptom is common among so-called \"long-haulers\" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists.\n\n- MORE HEALTH\n- [Pennsylvania to establish COVID-19 vaccine sites for teachers, school staffers](https:\/\/www.phillyvoice.com\/covid-19-vaccine-sites-pennsylvania-teachers-johnson-johnson\/)\n- [FEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot](https:\/\/www.phillyvoice.com\/philly-covid-19-vaccine-sites-convention-center-fema-\/)\n- [The immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say](https:\/\/www.phillyvoice.com\/mis-c-research-covid-19-treatments-chop-penn\/)\n\nBrain fog has taken the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium.\n\nThe symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as \"COVID brain.\" The medical term for it is [encephalopathy.](https:\/\/www.mskcc.org\/news\/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19)\n\nThe cause of this lingering symptom is becoming more clear thanks to two small studies.\n\nOne study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found.\n\n\"To have megakaryocytes in the brain has never been seen before,\" Dr. David Nauen, a pathologist at John Hopkins University who led the study, told [ABC News](https:\/\/abcnews.go.com\/Health\/scientists-inch-closer-explaining-mysterious-brain-fog-symptom\/story?id=76184080). \"I couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this.\"\n\nResearchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a \"significant\" amount of megakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly.\n\nThe study's results were published last month in the [Journal of the American Medical Association](https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2776455).\n\nAnother study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain.\n\nThe study, published in the journal [Cancer Cell](https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108\\(21\\)00051-9), sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. The researchers analyzed the brain scans and electroencephalogram results of 18 patients.\n\n\"We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having,\" [said](https:\/\/www.mskcc.org\/news\/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City.\n\nThe response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said.\n\n\"We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system,\" [said](https:\/\/www.sciencealert.com\/scientists-may-have-identified-what-causes-brain-fog-in-people-with-covid-19) Dr. Adrienne Boire, another researcher involved with the study. \"But the more we look, the more we find connections between the two.\"\n\nCAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms.\n\n![Allie Miller Headshot](https:\/\/media.phillyvoice.com\/media\/images\/012920-Allie-Miller-Headshot-300.5bc9f099.fill-108x90-c0.jpg)\n\n[Allie Miller](https:\/\/www.phillyvoice.com\/staff-contributors\/allie-miller\/)   \n  PhillyVoice Staff\n\nRead more [Adult Health](https:\/\/www.phillyvoice.com\/tags\/adult-health\/) [COVID-19](https:\/\/www.phillyvoice.com\/tags\/covid-19\/) [Philadelphia](https:\/\/www.phillyvoice.com\/tags\/philadelphia\/) [Studies](https:\/\/www.phillyvoice.com\/tags\/studies\/) [Neurology](https:\/\/www.phillyvoice.com\/tags\/neurology\/) [Coronavirus](https:\/\/www.phillyvoice.com\/tags\/coronavirus\/) [Research](https:\/\/www.phillyvoice.com\/tags\/research\/)\n\n### Follow us\n## Health Videos\n\n## Featured\n[![Purchased - Man holding blue ribbon supporting colon cancer awareness](https:\/\/media.phillyvoice.com\/media\/images\/iStock-2212351683.2e16d0ba.fill-265x140.jpg) Colon cancer: Rising in young adults](https:\/\/www.phillyvoice.com\/colon-cancer-rising-young-adults-md-anderson-cooper-0599935\/)\n\n[![Limited - Temple Health Dr. Toyoda](https:\/\/media.phillyvoice.com\/media\/images\/ewc_TempleDr.Toyoda-082024__439_vf.2e16d0ba.fill-265x140.jpg) Temple Lung Center sets U.S. record with 179 lung transplants in 2025](https:\/\/www.phillyvoice.com\/temple-lung-center-sets-us-record-179-lung-transplants-2025-05999-142\/)\n\nPlease enable JavaScript to view the [comments powered by Disqus.](https:\/\/disqus.com\/?ref_noscript)\n\n## Just In\n- [Newly accredited production facility in Philly offers tax incentives to movie and TV crews](https:\/\/www.phillyvoice.com\/story-factory-movie-film-production-facility-philly\/)\n- [U.S. fertility rate dropped to another record low in 2025, CDC report shows](https:\/\/www.phillyvoice.com\/fertility-rate-united-states-2025-births\/)\n- [Sixers center Joel Embiid will undergo surgery for appendicitis on Thursday](https:\/\/www.phillyvoice.com\/sixers-news-analysis-joel-embiid-will-undergo-surgery-appendicitis-thursday-injury-update-report-rumors-nba\/)\n- [Shriners Children's hospital starts its own 'Carpool Karaoke' for kids in its care](https:\/\/www.phillyvoice.com\/shriners-childrens-hospital-carpool-karaoke-remixed\/)\n- [A huge craft brewing conference is coming to Philly, and its official beer is a new Yards lager](https:\/\/www.phillyvoice.com\/craft-brewers-conference-yards-beer\/)\n- [A look at the 2026 NFL calendar, and how it pertains to the Eagles](https:\/\/www.phillyvoice.com\/look-2026-nfl-calendar-and-how-it-pertains-eagles-a-j-brown-draft-otas-schedule-release\/)\n\n- [Newly approved weight-loss pills could expand access to GLP-1s](https:\/\/www.phillyvoice.com\/weight-loss-pills-wegovy-foundayo\/)\n- [Healthy lifestyle habits lead to longevity. But they require emotional inspiration and logistical willpower](https:\/\/www.phillyvoice.com\/healthy-lifestyle-habits-longevity-motivation\/)\n- [Think you don’t have time to exercise? It may take less time than you think](https:\/\/www.phillyvoice.com\/think-you-dont-have-time-to-exercise-it-may-take-less-time-than-you-think-059991\/)\n- [Colon cancer: Rising in young adults](https:\/\/www.phillyvoice.com\/colon-cancer-rising-young-adults-md-anderson-cooper-0599935\/)\n- [Philly's new homeless shelter offers case management and medical services to 'set people up for success'](https:\/\/www.phillyvoice.com\/homelessness-shelter-social-services-housing\/)\n- [Yawning could help cool down the brain and strengthen social bonds](https:\/\/www.phillyvoice.com\/yawning-cool-brain-contagious-social-bonds\/)\n\n## Must Read\n[Investigations](https:\/\/www.phillyvoice.com\/tags\/investigations\/)\n\n[1 man dead, 2 missing after parking garage partially collapses](https:\/\/www.phillyvoice.com\/grays-ferry-parking-garage-collapse-philly-rescue\/)\n\n[![Grays Ferry Collapse](https:\/\/media.phillyvoice.com\/media\/images\/IMG_3780_YQ8CzaX.57dcaeeb.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/grays-ferry-parking-garage-collapse-philly-rescue\/)\n\n[Travel](https:\/\/www.phillyvoice.com\/tags\/travel\/)\n\n[Harford County spring blooms & festivals](https:\/\/www.phillyvoice.com\/spring-harford-county-brings-festivals-blooms-and-waterfront-views-05999-147\/)\n\n[![Limited - Hopkins Brewery](https:\/\/media.phillyvoice.com\/media\/images\/HelloHarford_PhillyVoice_April2026.2e16d0ba.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/spring-harford-county-brings-festivals-blooms-and-waterfront-views-05999-147\/)\n\n[Prevention](https:\/\/www.phillyvoice.com\/tags\/prevention\/)\n\n[Poison centers are fielding more calls tied to kava use](https:\/\/www.phillyvoice.com\/kava-poison-control-calls-health-risks\/)\n\n[![Kava Poison Centers](https:\/\/media.phillyvoice.com\/media\/images\/040826KavaPoisonControl.2e16d0ba.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/kava-poison-control-calls-health-risks\/)\n\n[Philadelphia 250](https:\/\/www.phillyvoice.com\/tags\/philadelphia-250\/)\n\n[Smith Memorial Playground to collect letters from kids for a time capsule](https:\/\/www.phillyvoice.com\/smith-memorial-playground-time-capsule-2076\/)\n\n[![Smith Playground time capsule](https:\/\/media.phillyvoice.com\/media\/images\/040826_smith_playground_time_capsu.2e16d0ba.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/smith-memorial-playground-time-capsule-2076\/)\n\n[Summer](https:\/\/www.phillyvoice.com\/tags\/summer\/)\n\n[Longwood Gardens kicks off Festival of Fountains on May 8 with daily shows and illuminated nights](https:\/\/www.phillyvoice.com\/longwood-gardens-festival-of-fountains-2026\/)\n\n[![417913\\_Monet\\_s Garden Becca Mathias for Longwood Gardens.jpg](https:\/\/media.phillyvoice.com\/media\/images\/417913_Monet_s_Garden_Becca_Mathia.2e16d0ba.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/longwood-gardens-festival-of-fountains-2026\/)\n\n[Flyers](https:\/\/www.phillyvoice.com\/tags\/flyers\/)\n\n[The Flyers are different now. They grew up.](https:\/\/www.phillyvoice.com\/flyers-grew-up-nhl-playoffs-odds-trevor-zegras-travis-konecny-rebuild-path\/)\n\n[![Owen-Tippett-Dan-Vladar-Flyers-Win-4.5.26-NHL.jpg](https:\/\/media.phillyvoice.com\/media\/images\/USATSI_28666200.50b06b00.fill-100x100.jpg)](https:\/\/www.phillyvoice.com\/flyers-grew-up-nhl-playoffs-odds-trevor-zegras-travis-konecny-rebuild-path\/)\n\n- [About PhillyVoice.com](https:\/\/www.phillyvoice.com\/about-us\/)\n- [About aHealthierPhilly](https:\/\/www.phillyvoice.com\/about-us#ahealthierphilly)\n- [Contact Us](https:\/\/www.phillyvoice.com\/contact-us\/)\n- [Legal \/ Privacy](https:\/\/www.phillyvoice.com\/legal-privacy-ethics\/)\n- [Staff \/ Contributors](https:\/\/www.phillyvoice.com\/staff-contributors\/)\n- [RSS](https:\/\/www.phillyvoice.com\/rss-feeds\/)\n\nThe contents of this website, such as text, graphics, images, and other material contained on this website, are for informational purposes only and do not constitute medical advice.\n\na**healthier**philly is sponsored by Independence Blue Cross, the leading health insurance organization in Southeastern Pennsylvania, serving nearly 2.5 million people in the region, providing health news and related information that leads to a more informed, healthier life.\n\na**healthier**philly and its health-related information resources are not a substitute for the medical advice, diagnosis, and treatment that patients receive from their physicians or health care providers and are not meant to be the practice of medicine, the practice of nursing, or to carry out any professional health care advice or service in the state where you live. Nothing in this website is meant to be used for medical or nursing diagnosis or professional treatment.\n\nAlways seek the advice of your physician or other licensed health care provider. Always consult your health care provider before beginning any new treatment, or if you have any questions regarding your health condition. You should not disregard medical advice, or delay seeking medical advice, because of something you read on this site. In the event of a medical emergency, call a doctor or 911 immediately.\n\nThis website does not recommend or endorse any specific tests, physicians, procedures, opinions, or other information that may be mentioned on this website. Descriptions of, references to, or links to other products, publications, or services does not imply endorsement of any kind. Reliance on any information provided by this website is solely at your own risk.\n\nAlthough we try to keep the information on the site as accurate as possible, a**healthier**philly disclaims any warranty concerning its accuracy, timeliness and completeness of content, and any other warranty, express or implied, including warranties of merchantability or fitness for a particular purpose. a**healthier**philly also reserves the right to temporarily or permanently discontinue this website, any page or any functionality at any time and without any notice.\n\nThe website and its content are provided on an “as is” basis.\n\n© 2026 WWB Holdings, LLC. All rights reserved","attrs_readable_markdown":"Scientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19.\n\nThe symptom is common among so-called \"long-haulers\" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists.\n\n- MORE HEALTH\n- [Pennsylvania to establish COVID-19 vaccine sites for teachers, school staffers](https:\/\/www.phillyvoice.com\/covid-19-vaccine-sites-pennsylvania-teachers-johnson-johnson\/)\n- [FEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot](https:\/\/www.phillyvoice.com\/philly-covid-19-vaccine-sites-convention-center-fema-\/)\n- [The immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say](https:\/\/www.phillyvoice.com\/mis-c-research-covid-19-treatments-chop-penn\/)\n\nBrain fog has taken the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium.\n\nThe symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as \"COVID brain.\" The medical term for it is [encephalopathy.](https:\/\/www.mskcc.org\/news\/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19)\n\nThe cause of this lingering symptom is becoming more clear thanks to two small studies.\n\nOne study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found.\n\n\"To have megakaryocytes in the brain has never been seen before,\" Dr. David Nauen, a pathologist at John Hopkins University who led the study, told [ABC News](https:\/\/abcnews.go.com\/Health\/scientists-inch-closer-explaining-mysterious-brain-fog-symptom\/story?id=76184080). \"I couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this.\"\n\nResearchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a \"significant\" amount of megakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly.\n\nThe study's results were published last month in the [Journal of the American Medical Association](https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/2776455).\n\nAnother study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain.\n\nThe study, published in the journal [Cancer Cell](https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108\\(21\\)00051-9), sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. The researchers analyzed the brain scans and electroencephalogram results of 18 patients.\n\n\"We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having,\" [said](https:\/\/www.mskcc.org\/news\/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City.\n\nThe response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said.\n\n\"We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system,\" [said](https:\/\/www.sciencealert.com\/scientists-may-have-identified-what-causes-brain-fog-in-people-with-covid-19) Dr. Adrienne Boire, another researcher involved with the study. \"But the more we look, the more we find connections between the two.\"\n\nCAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms.","meta_canonical":null}

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URL	https://www.phillyvoice.com/covid-brain-fog-cause-coronavirus-long-haulers-symptoms/
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Meta Title	Scientists gain new insights into the cause of 'COVID brain' \| PhillyVoice
Meta Description	Researchers are getting closer to understanding why some people experience brain fog after recovering from COVID-19. Two studies offer new insights into why some people suffer confusion, short-term memory loss or severe delirium after a coronavirus infection.
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Boilerpipe Text	Scientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19. The symptom is common among so-called "long-haulers" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists. MORE HEALTH Pennsylvania to establish COVID-19 vaccine sites for teachers, school staffers FEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot The immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say Brain fog has taken the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium. The symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as "COVID brain." The medical term for it is encephalopathy. The cause of this lingering symptom is becoming more clear thanks to two small studies. One study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found. "To have megakaryocytes in the brain has never been seen before," Dr. David Nauen, a pathologist at John Hopkins University who led the study, told ABC News . " I couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this." Researchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a "significant" amount of megakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly. The study's results were published last month in the Journal of the American Medical Association . Another study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain. The study, published in the journal Cancer Cell , sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. The researchers analyzed the brain scans and electroencephalogram results of 18 patients. "We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having," said Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City. The response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said. "We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system," said Dr. Adrienne Boire, another researcher involved with the study. "But the more we look, the more we find connections between the two." CAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms.
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All rights reserved ### More Health: - [Health News](https://www.phillyvoice.com/tags/health-news/) - [Parenting](https://www.phillyvoice.com/tags/parenting/) - [Wellness](https://www.phillyvoice.com/tags/wellness/) - [Healthy Eating](https://www.phillyvoice.com/tags/healthy-eating/) - [Mental Health](https://www.phillyvoice.com/tags/mental-health/) - [Addiction](https://www.phillyvoice.com/tags/addiction/) - [Newsletters](https://www.phillyvoice.com/newsletters/) March 05, 2021 # Scientists zeroing in on the cause of 'COVID brain' ## Some people experience confusion, short-term memory loss or difficulty concentrating months after recovering from the coronavirus ![Allie Miller Headshot](https://media.phillyvoice.com/media/images/012920-Allie-Miller-Headshot-300x.5bc9f099.fill-54x45-c0.jpg) By [Allie Miller](https://www.phillyvoice.com/staff-contributors/allie-miller/) PhillyVoice Staff [Adult Health](https://www.phillyvoice.com/tags/adult-health/) [COVID-19](https://www.phillyvoice.com/tags/covid-19/) from [![IBC-Logo-125x21](https://media.phillyvoice.com/media/images/IBC-300-PNG24-101725-04.max-125x32.png)](https://www.ibx.com/) ![brain fog coronavirus](https://media.phillyvoice.com/media/images/030521_COVID_Brain_Fog.2e16d0ba.fill-735x490.jpg) Dylan Ferreira/Unsplash.com New research offers insights into the reason some people experience neurological symptoms, like short-term memory loss and confusion, months after recovering from COVID-19. [Read More](https://www.phillyvoice.com/covid-brain-fog-cause-coronavirus-long-haulers-symptoms/) Scientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19. The symptom is common among so-called "long-haulers" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists. - MORE HEALTH - [Pennsylvania to establish COVID-19 vaccine sites for teachers, school staffers](https://www.phillyvoice.com/covid-19-vaccine-sites-pennsylvania-teachers-johnson-johnson/) - [FEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot](https://www.phillyvoice.com/philly-covid-19-vaccine-sites-convention-center-fema-/) - [The immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say](https://www.phillyvoice.com/mis-c-research-covid-19-treatments-chop-penn/) Brain fog has taken the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium. The symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as "COVID brain." The medical term for it is [encephalopathy.](https://www.mskcc.org/news/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) The cause of this lingering symptom is becoming more clear thanks to two small studies. One study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found. "To have megakaryocytes in the brain has never been seen before," Dr. David Nauen, a pathologist at John Hopkins University who led the study, told [ABC News](https://abcnews.go.com/Health/scientists-inch-closer-explaining-mysterious-brain-fog-symptom/story?id=76184080). "I couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this." Researchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a "significant" amount of megakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly. The study's results were published last month in the [Journal of the American Medical Association](https://jamanetwork.com/journals/jamaneurology/fullarticle/2776455). Another study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain. The study, published in the journal [Cancer Cell](https://www.cell.com/cancer-cell/fulltext/S1535-6108\(21\)00051-9), sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. The researchers analyzed the brain scans and electroencephalogram results of 18 patients. "We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having," [said](https://www.mskcc.org/news/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City. The response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said. "We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system," [said](https://www.sciencealert.com/scientists-may-have-identified-what-causes-brain-fog-in-people-with-covid-19) Dr. Adrienne Boire, another researcher involved with the study. "But the more we look, the more we find connections between the two." CAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms. ![Allie Miller Headshot](https://media.phillyvoice.com/media/images/012920-Allie-Miller-Headshot-300.5bc9f099.fill-108x90-c0.jpg) [Allie Miller](https://www.phillyvoice.com/staff-contributors/allie-miller/) PhillyVoice Staff Read more [Adult Health](https://www.phillyvoice.com/tags/adult-health/) [COVID-19](https://www.phillyvoice.com/tags/covid-19/) [Philadelphia](https://www.phillyvoice.com/tags/philadelphia/) [Studies](https://www.phillyvoice.com/tags/studies/) [Neurology](https://www.phillyvoice.com/tags/neurology/) [Coronavirus](https://www.phillyvoice.com/tags/coronavirus/) [Research](https://www.phillyvoice.com/tags/research/) ### Follow us ## Health Videos ## Featured [![Purchased - Man holding blue ribbon supporting colon cancer awareness](https://media.phillyvoice.com/media/images/iStock-2212351683.2e16d0ba.fill-265x140.jpg) Colon cancer: Rising in young adults](https://www.phillyvoice.com/colon-cancer-rising-young-adults-md-anderson-cooper-0599935/) [![Limited - Temple Health Dr. Toyoda](https://media.phillyvoice.com/media/images/ewc_TempleDr.Toyoda-082024__439_vf.2e16d0ba.fill-265x140.jpg) Temple Lung Center sets U.S. record with 179 lung transplants in 2025](https://www.phillyvoice.com/temple-lung-center-sets-us-record-179-lung-transplants-2025-05999-142/) Please enable JavaScript to view the [comments powered by Disqus.](https://disqus.com/?ref_noscript) ## Just In - [Newly accredited production facility in Philly offers tax incentives to movie and TV crews](https://www.phillyvoice.com/story-factory-movie-film-production-facility-philly/) - [U.S. fertility rate dropped to another record low in 2025, CDC report shows](https://www.phillyvoice.com/fertility-rate-united-states-2025-births/) - [Sixers center Joel Embiid will undergo surgery for appendicitis on Thursday](https://www.phillyvoice.com/sixers-news-analysis-joel-embiid-will-undergo-surgery-appendicitis-thursday-injury-update-report-rumors-nba/) - [Shriners Children's hospital starts its own 'Carpool Karaoke' for kids in its care](https://www.phillyvoice.com/shriners-childrens-hospital-carpool-karaoke-remixed/) - [A huge craft brewing conference is coming to Philly, and its official beer is a new Yards lager](https://www.phillyvoice.com/craft-brewers-conference-yards-beer/) - [A look at the 2026 NFL calendar, and how it pertains to the Eagles](https://www.phillyvoice.com/look-2026-nfl-calendar-and-how-it-pertains-eagles-a-j-brown-draft-otas-schedule-release/) - [Newly approved weight-loss pills could expand access to GLP-1s](https://www.phillyvoice.com/weight-loss-pills-wegovy-foundayo/) - [Healthy lifestyle habits lead to longevity. 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Readable Markdown	Scientists believe they are getting closer to understanding why some people experience brain fog after they have recovered from COVID-19. The symptom is common among so-called "long-haulers" — people whose symptoms linger three to six months after testing positive for the coronavirus. For some people, brain fog is the only symptom that persists. - MORE HEALTH - [Pennsylvania to establish COVID-19 vaccine sites for teachers, school staffers](https://www.phillyvoice.com/covid-19-vaccine-sites-pennsylvania-teachers-johnson-johnson/) - [FEMA opens vaccination site in Philly: How to make an appointment for a COVID-19 shot](https://www.phillyvoice.com/philly-covid-19-vaccine-sites-convention-center-fema-/) - [The immune response to MIS-C may hold clues to improving COVID-19 treatments, Philly researchers say](https://www.phillyvoice.com/mis-c-research-covid-19-treatments-chop-penn/) Brain fog has taken the forms of short-term memory loss, confusion and difficulty concentrating. Some people also have experienced psychosis or delirium. The symptom has become so commonly associated with coronavirus patients that it's sometimes referred to as "COVID brain." The medical term for it is [encephalopathy.](https://www.mskcc.org/news/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) The cause of this lingering symptom is becoming more clear thanks to two small studies. One study suggests brain fog may result from megakaryocytes — a large type of cell — blocking blood and oxygen from passing to the brain, a location where they typically are not found. "To have megakaryocytes in the brain has never been seen before," Dr. David Nauen, a pathologist at John Hopkins University who led the study, told [ABC News](https://abcnews.go.com/Health/scientists-inch-closer-explaining-mysterious-brain-fog-symptom/story?id=76184080). "I couldn't find any reference in my search this past summer with megakaryocytes noted in human brain capillaries. This is very new for COVID that they are doing this." Researchers evaluated the brain tissue of 15 COVID-19 victims and two people who had died of other causes. They found a "significant" amount of megakaryocytes in the COVID-19 victims. The blockage these cells create prevents the brain from getting the nutrients it needs to function properly. The study's results were published last month in the [Journal of the American Medical Association](https://jamanetwork.com/journals/jamaneurology/fullarticle/2776455). Another study suggests brain fog may be the result of inflammation sparked by the arrival of cytokines, small proteins released by the immune system, to the brain. The study, published in the journal [Cancer Cell](https://www.cell.com/cancer-cell/fulltext/S1535-6108\(21\)00051-9), sought to determine why some COVID-19 patients with cancer were experiencing severe delirium. The researchers analyzed the brain scans and electroencephalogram results of 18 patients. "We found that these patients had persistent inflammation and high levels of cytokines in their cerebrospinal fluid, which explained the symptoms they were having," [said](https://www.mskcc.org/news/msk-researchers-learn-what-s-driving-brain-fog-people-covid-19) Jan Remsik, a research fellow at the Memorial Sloan Kettering Cancer Center in New York City. The response was similar to the inflammatory markers found in people who have received CAR T cell therapy, a cancer treatment known to prompt neurologic symptoms days or weeks later, researchers said. "We used to think that the nervous system was an immune-privileged organ, meaning that it didn’t have any kind of relationship at all with the immune system," [said](https://www.sciencealert.com/scientists-may-have-identified-what-causes-brain-fog-in-people-with-covid-19) Dr. Adrienne Boire, another researcher involved with the study. "But the more we look, the more we find connections between the two." CAR T cell patients who develop neurologic symptoms are treated with anti-inflammatory medications. But the researchers said doctors don't yet know the role they will play in treating COVID-19 patients with neurologic symptoms.
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