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URLhttps://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue
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Meta TitleFatigue | Parkinson's Foundation
Meta DescriptionAbout half of people with PD report that fatigue is a major problem and one third say it is their most disabling symptom.
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💡 Quick Summary Fatigue is a common and disabling symptom of Parkinson’s disease, affecting physical and mental energy.  It is distinct from sleepiness and can occur at any stage of Parkinson’s, often worsening with stress,  depression , pain or medication side effects.  Causes are complex and not fully understood, but fatigue may result from a combination of PD-related brain changes, other medical conditions or medication side effects; identifying and addressing these contributors is key.  Managing fatigue involves lifestyle and behavioral strategies.  Do you or a loved one with Parkinson’s disease (PD) feel physically or mentally exhausted? This could be fatigue ― a feeling of deep tiredness that does not improve with rest. About half of people with PD report that fatigue is a major problem and one third say it is their most disabling symptom. Fatigue is different from sleepiness. A person who is fatigued feels exhausted, however, does not necessarily feel like sleeping. Fatigue symptoms include: Physical fatigue: feeling deeply tired or weary ― this may worsen with “off” fluctuations. Mental fatigue: mental tiredness that makes it difficult to concentrate. Fatigue is common early in the course of PD, but can occur at any point and can happen whether movement symptoms are mild or severe. Fatigue can occur on its own or along with other symptoms such as sleep disturbances, pain, or depression. Stress can make fatigue worse. The cause of fatigue in PD is unknown. It is possible that motor symptoms like tremor and stiffness contribute to making muscles tired, but because fatigue occurs even in those with mild motor symptoms, this is probably not the only explanation. It is important to consider that fatigue can have causes outside of Parkinson’s, too. It is important to identify illnesses or medications unrelated to PD that may contribute to fatigue. The impact of fatigue can be severe. Extreme exhaustion that comes with fatigue can lead people to avoid social activities, reduce hours at work, or even retire. Understanding fatigue as a symptom of PD and finding ways to cope with it are essential to maintaining a good quality of life. Therapies Few therapies have been tested for fatigue in PD and none have been proven effective against fatigue on its own. Optimizing medications for movement symptoms does not typically help fatigue. Despite this, there are strategies and tips that can help: When fatigue is mixed with other symptoms, targeting those other symptoms may help a person feel more energetic. For example, treating sleep disturbances can help a person sleep soundly through the night and therefore less fatigued the following day. Treating depression and pain can also be effective in reducing fatigue. Some medications for PD motor symptoms may contribute to fatigue or make you sleepy. Adjusting doses of these medications may help solve the problem. Work with your primary care doctor to identify and treat any medical causes of fatigue besides PD, such as anemia, thyroid disease, low blood pressure, sleep apnea, nutritional deficiencies in vitamin D, B vitamins, etc. Talk with your doctor before taking any vitamins or supplements. These may interact with medications for PD or other disorders. Talk to your primary care doctor about medications you take that are not for PD — these also may contribute to fatigue. Although little research has been done to evaluate stimulants like amphetamine salts, your physician may recommend trying a low dose if you are otherwise healthy. Not all doctors support this approach. Tips for Coping with Fatigue Eat well . Stay hydrated. Exercise . Walk, do Tai Chi, dance, cycle, swim, do Yoga or chair Yoga — whatever you enjoy. Fatigue may make it hard to start exercising, but it may make you feel more energetic afterward. If you find it difficult to get going, consider exercising with another person or a group. Keep a regular sleep schedule. If you have difficulty sleeping because of tremor or stiffness, trouble rolling over or needing to use the bathroom, talk to your doctor about these issues. Take a short nap (10 to 30 minutes) after lunch. Avoid frequent naps, long naps, or napping after 3 p.m. Stay socially connected. Pace yourself: plan your day so that you are active at times when you feel most energetic and have a chance to rest when you need to. Do something fun: visit with an upbeat friend or pursue a hobby. At work, take regular short breaks. Fatigue has been identified by the PD community as an unmet need. Research to understand and solve fatigue in PD is ongoing. Page reviewed by Dr. Addie Patterson, Movement Disorders Neurologist at the Norman Fixel Institute for Neurological Diseases at the University of Florida, a Parkinson’s Foundation Center of Excellence.
Markdown
[Skip to main content](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue#maincontent) Close - Understanding Parkinson’s - [Understanding Parkinson’s](https://www.parkinson.org/understanding-parkinsons) - [What is Parkinson's?](https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons) - [10 Early Signs](https://www.parkinson.org/understanding-parkinsons/10-early-signs) - [Causes](https://www.parkinson.org/understanding-parkinsons/causes) - [Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/movement-symptoms) - [Non-Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms) - [Getting Diagnosed](https://www.parkinson.org/understanding-parkinsons/getting-diagnosed) - [Statistics](https://www.parkinson.org/understanding-parkinsons/statistics) - Living with Parkinson’s - [Living With Parkinson’s](https://www.parkinson.org/living-with-parkinsons) - [New to Parkinson's](https://www.parkinson.org/living-with-parkinsons/new-to-parkinsons) - [Our Care Programs](https://www.parkinson.org/living-with-parkinsons/care-programs) - [Finding Care](https://www.parkinson.org/living-with-parkinsons/finding-care) - [Treatment](https://www.parkinson.org/living-with-parkinsons/treatment) - [Management & Lifestyle](https://www.parkinson.org/living-with-parkinsons/management) - [Emotional & Mental Health](https://www.parkinson.org/living-with-parkinsons/emotional-mental-health) - [Legal, Financial & Insurance](https://www.parkinson.org/living-with-parkinsons/legal-financial) - [My PD Story](https://www.parkinson.org/living-with-parkinsons/stories) - Resources & Support - [Resources & Support](https://www.parkinson.org/resources-support) - [Helpline](https://www.parkinson.org/resources-support/helpline) - [In Your Area](https://www.parkinson.org/your-area) - [PD Library](https://www.parkinson.org/resources-support/pd-library) - [Hospital Safety Guide](https://www.parkinson.org/resources-support/hospital-safety-guide) - [Online Education](https://www.parkinson.org/resources-support/online-education) - [Events](https://www.parkinson.org/resources-support/events) - [Community Grants](https://www.parkinson.org/resources-support/community-grants) - [For Care Partners](https://www.parkinson.org/resources-support/carepartners) - [For Professionals](https://www.parkinson.org/resources-support/professionals) - [Find Your Chapter](https://www.parkinson.org/resources-support/find-your-chapter) - [Blog](https://www.parkinson.org/resources-support/blog) - Advancing Research - [Advancing Research](https://www.parkinson.org/advancing-research) - [Finding A Cure](https://www.parkinson.org/advancing-research/finding-cure) - [Our Research](https://www.parkinson.org/advancing-research/our-research) - [Join A Study](https://www.parkinson.org/advancing-research/join-study) - [Advocate for Research](https://www.parkinson.org/advancing-research/advocate-research) - [For Researchers](https://www.parkinson.org/advancing-research/for-researchers) - [Parkinson’s Virtual Biotech](https://www.parkinson.org/advancing-research/parkinsons-virtual-biotech) - How You Can Help - [How You Can Help](https://www.parkinson.org/how-to-help) - [Donate Now](https://www.parkinson.org/how-to-help/donate) - [Why Support Us](https://www.parkinson.org/how-to-help/why-support-us) - [Make a Tribute Gift](https://www.parkinson.org/how-to-help/tribute) - [Fundraise](https://www.parkinson.org/how-to-help/fundraise) - [Volunteer](https://www.parkinson.org/how-to-help/volunteer) - [Corporate Sponsors](https://www.parkinson.org/how-to-help/corporate-sponsors) - [Planned Giving](https://www.parkinson.org/how-to-help/more-ways-to-give/planned-giving) - [More Ways to Give](https://www.parkinson.org/how-to-help/more-ways-to-give) - [Policy & Advocacy](https://www.parkinson.org/how-to-help/policy-advocacy-priorities) [Blog](https://www.parkinson.org/resources-support/blog) [In Your Area](https://www.parkinson.org/your-area) [About Us](https://www.parkinson.org/about-us) [Donate](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue?form=19983) [Español](https://www.parkinson.org/espanol) [Helpline](tel:18004734636) [Call our Helpline: 1-800-4PD-INFO (473-4636)](https://www.parkinson.org/helpline) - [Español](https://www.parkinson.org/espanol) - [About Us](https://www.parkinson.org/about-us) - [Blog](https://www.parkinson.org/resources-support/blog) - [In Your Area](https://www.parkinson.org/your-area) - Search - [Donate](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue?form=19983) [General Gift](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue?form=19983) [Tribute Gift](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue?form=19983&tribute=true) [Find a Fundraiser](https://secure3.convio.net/prkorg/site/SPageNavigator/fundraiser_search.html) - Understanding Parkinson’s Understanding Parkinson’s There is a lot to know about Parkinson's disease. Learn about symptoms, how it is diagnosed and what treatment options are available. - [Understanding Parkinson’s](https://www.parkinson.org/understanding-parkinsons) - [What is Parkinson's?](https://www.parkinson.org/understanding-parkinsons/what-is-parkinsons) - [10 Early Signs](https://www.parkinson.org/understanding-parkinsons/10-early-signs) - [Causes](https://www.parkinson.org/understanding-parkinsons/causes) - [Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/movement-symptoms) - [Non-Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms) - [Getting Diagnosed](https://www.parkinson.org/understanding-parkinsons/getting-diagnosed) - [Statistics](https://www.parkinson.org/understanding-parkinsons/statistics) - Living with Parkinson’s Living with Parkinson’s While living with PD can be challenging, there are many things you can do to maintain and improve your quality of life and live well with Parkinson's disease. - [Living With Parkinson’s](https://www.parkinson.org/living-with-parkinsons) - [New to Parkinson's](https://www.parkinson.org/living-with-parkinsons/new-to-parkinsons) - [Our Care Programs](https://www.parkinson.org/living-with-parkinsons/care-programs) - [Finding Care](https://www.parkinson.org/living-with-parkinsons/finding-care) - [Treatment](https://www.parkinson.org/living-with-parkinsons/treatment) - [Management & Lifestyle](https://www.parkinson.org/living-with-parkinsons/management) - [Emotional & Mental Health](https://www.parkinson.org/living-with-parkinsons/emotional-mental-health) - [Legal, Financial & Insurance](https://www.parkinson.org/living-with-parkinsons/legal-financial) - [My PD Story](https://www.parkinson.org/living-with-parkinsons/stories) - Resources & Support Resources & Support Living well with Parkinson’s disease (PD) means getting the support you need — from tools that help you work alongside your care team to resources that empower you. - [Resources & Support](https://www.parkinson.org/resources-support) - [Helpline](https://www.parkinson.org/resources-support/helpline) - [In Your Area](https://www.parkinson.org/your-area) - [PD Library](https://www.parkinson.org/resources-support/pd-library) - [Hospital Safety Guide](https://www.parkinson.org/resources-support/hospital-safety-guide) - [Online Education](https://www.parkinson.org/resources-support/online-education) - [Events](https://www.parkinson.org/resources-support/events) - [Community Grants](https://www.parkinson.org/resources-support/community-grants) - [For Care Partners](https://www.parkinson.org/resources-support/carepartners) - [For Professionals](https://www.parkinson.org/resources-support/professionals) - [Find Your Chapter](https://www.parkinson.org/resources-support/find-your-chapter) - [Blog](https://www.parkinson.org/resources-support/blog) - Advancing Research Advancing Research Our research has led to breakthroughs in treatment and improved care that bring hope to the entire Parkinson's community. - [Advancing Research](https://www.parkinson.org/advancing-research) - [Finding A Cure](https://www.parkinson.org/advancing-research/finding-cure) - [Our Research](https://www.parkinson.org/advancing-research/our-research) - [Join A Study](https://www.parkinson.org/advancing-research/join-study) - [Advocate for Research](https://www.parkinson.org/advancing-research/advocate-research) - [For Researchers](https://www.parkinson.org/advancing-research/for-researchers) - [Parkinson’s Virtual Biotech](https://www.parkinson.org/advancing-research/parkinsons-virtual-biotech) - How You Can Help How You Can Help There are many ways you can support the fight against Parkinson’s. Whatever form your gift takes, you can be confident that it goes toward providing crucial resources for those affected by this disease. - [How You Can Help](https://www.parkinson.org/how-to-help) - [Donate Now](https://www.parkinson.org/how-to-help/donate) - [Why Support Us](https://www.parkinson.org/how-to-help/why-support-us) - [Make a Tribute Gift](https://www.parkinson.org/how-to-help/tribute) - [Fundraise](https://www.parkinson.org/how-to-help/fundraise) - [Volunteer](https://www.parkinson.org/how-to-help/volunteer) - [Corporate Sponsors](https://www.parkinson.org/how-to-help/corporate-sponsors) - [Planned Giving](https://www.parkinson.org/how-to-help/more-ways-to-give/planned-giving) - [More Ways to Give](https://www.parkinson.org/how-to-help/more-ways-to-give) - [Policy & Advocacy](https://www.parkinson.org/how-to-help/policy-advocacy-priorities) ## Breadcrumb - [Home](https://www.parkinson.org/) - [Understanding Parkinson's](https://www.parkinson.org/understanding-parkinsons) - [Non-Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms) ## Breadcrumb - [Home](https://www.parkinson.org/) - [Understanding Parkinson's](https://www.parkinson.org/understanding-parkinsons) - [Non-Movement Symptoms](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms) # Fatigue IN THIS SECTION IN THIS SECTION - [Anxiety](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/anxiety) - [Apathy](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/apathy) - [Bladder Issues & Incontinence](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/incontinence) - [Breathing & Respiratory Difficulties](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/breathing) - [Cognitive Changes](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/cognitive) - [Constipation & Nausea](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/constipation) - [Dementia](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/dementia) View Menu - [Dementia with Lewy Bodies](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/dementia/lewy-bodies) - [Depression](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/depression) - [Fatigue](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/fatigue) - [Hallucinations/Delusions](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/hallucinations-delusions) - [Loss of Smell](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/loss-of-smell) - [Pain](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/pain) - [Skeletal & Bone Health](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/bone-health) - [Skin Changes](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/skin) - [Sleep Disorders](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/sleep-disorders) - [Speech & Swallowing Issues](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/speech-swallowing) - [Vertigo, Dizziness & Low Blood Pressure](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/vertigo) - [Vision Changes](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/vision) - [Weight Management](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/weight-management) ## 💡 Quick Summary - Fatigue is a common and disabling symptom of Parkinson’s disease, affecting physical and mental energy. - It is distinct from sleepiness and can occur at any stage of Parkinson’s, often worsening with stress, [depression](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/depression "Depression"), pain or medication side effects. - Causes are complex and not fully understood, but fatigue may result from a combination of PD-related brain changes, other medical conditions or medication side effects; identifying and addressing these contributors is key. - Managing fatigue involves lifestyle and behavioral strategies. ![Man rubbing his eyes with the back of his hand](https://www.parkinson.org/sites/default/files/styles/no_sizing/public/images/fatigue.jpg?itok=PJuH1IsV) Do you or a loved one with Parkinson’s disease (PD) feel physically or mentally exhausted? This could be fatigue ― a feeling of deep tiredness that does not improve with rest. About half of people with PD report that fatigue is a major problem and one third say it is their most disabling symptom. Fatigue is different from sleepiness. A person who is fatigued feels exhausted, however, does not necessarily feel like sleeping. **Fatigue symptoms include:** - Physical fatigue: feeling deeply tired or weary ― this may worsen with “off” fluctuations. - Mental fatigue: mental tiredness that makes it difficult to concentrate. Fatigue is common early in the course of PD, but can occur at any point and can happen whether movement symptoms are mild or severe. Fatigue can occur on its own or along with other symptoms such as sleep disturbances, pain, or depression. Stress can make fatigue worse. The cause of fatigue in PD is unknown. It is possible that motor symptoms like tremor and stiffness contribute to making muscles tired, but because fatigue occurs even in those with mild motor symptoms, this is probably not the only explanation. It is important to consider that fatigue can have causes outside of Parkinson’s, too. It is important to identify illnesses or medications unrelated to PD that may contribute to fatigue. The impact of fatigue can be severe. Extreme exhaustion that comes with fatigue can lead people to avoid social activities, reduce hours at work, or even retire. Understanding fatigue as a symptom of PD and finding ways to cope with it are essential to maintaining a good quality of life. ## Therapies Few therapies have been tested for fatigue in PD and none have been proven effective against fatigue on its own. Optimizing medications for movement symptoms does not typically help fatigue. Despite this, there are strategies and tips that can help: - When fatigue is mixed with other symptoms, targeting those other symptoms may help a person feel more energetic. For example, treating sleep disturbances can help a person sleep soundly through the night and therefore less fatigued the following day. Treating depression and pain can also be effective in reducing fatigue. - Some medications for PD motor symptoms may contribute to fatigue or make you sleepy. Adjusting doses of these medications may help solve the problem. - Work with your primary care doctor to identify and treat any medical causes of fatigue besides PD, such as anemia, thyroid disease, low blood pressure, sleep apnea, nutritional deficiencies in vitamin D, B vitamins, etc. - Talk with your doctor before taking any vitamins or supplements. These may interact with medications for PD or other disorders. - Talk to your primary care doctor about medications you take that are not for PD — these also may contribute to fatigue. - Although little research has been done to evaluate stimulants like amphetamine salts, your physician may recommend trying a low dose if you are otherwise healthy. Not all doctors support this approach. ### Tips for Coping with Fatigue - [Eat well](https://www.parkinson.org/living-with-parkinsons/management/diet-nutrition "Diet & Nutrition"). - Stay hydrated. - [Exercise](https://www.parkinson.org/living-with-parkinsons/treatment/exercise "Exercise"). Walk, do Tai Chi, dance, cycle, swim, do Yoga or chair Yoga — whatever you enjoy. Fatigue may make it hard to start exercising, but it may make you feel more energetic afterward. If you find it difficult to get going, consider exercising with another person or a group. - Keep a regular sleep schedule. If you have [difficulty sleeping](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/sleep-disorders "Sleep Disorders") because of tremor or stiffness, trouble rolling over or needing to use the bathroom, talk to your doctor about these issues. - Take a short nap (10 to 30 minutes) after lunch. Avoid frequent naps, long naps, or napping after 3 p.m. - Stay socially connected. - Pace yourself: plan your day so that you are active at times when you feel most energetic and have a chance to rest when you need to. - Do something fun: visit with an upbeat friend or pursue a hobby. - At work, take regular short breaks. Fatigue has been identified by the PD community as an unmet need. Research to understand and solve fatigue in PD is ongoing. *Page reviewed by Dr. Addie Patterson, Movement Disorders Neurologist at the Norman Fixel Institute for Neurological Diseases at the University of Florida, a Parkinson’s Foundation Center of Excellence.* ## Related Materials Fact Sheets ### [Fatigue](https://www.parkinson.org/library/fact-sheets/fatigue) [Read Now](https://www.parkinson.org/library/fact-sheets/fatigue) Videos & Webinars ### [Exploring Non-Motor Symptoms: Neuropathy, Fatigue, GI Issues](https://www.parkinson.org/library/videos/neuropathy) [Watch Now](https://www.parkinson.org/library/videos/neuropathy) Podcasts ### [Episode 65: Recognizing Non-motor Symptoms in PD](https://www.parkinson.org/library/podcast/65) [Listen Now](https://www.parkinson.org/library/podcast/65) ## Related Blog Posts ![Doctor supporting an older woman](https://www.parkinson.org/sites/default/files/styles/500x360/public/images/tacklingneuropathyfatiguegi-blog.jpg?h=478ba18f&itok=omkr7a1L) Tips for Daily Living ### [Tackling Neuropathy, Fatigue and GI Issues in PD](https://www.parkinson.org/blog/awareness/neuropathy) READ NOW ![Woman sleeping](https://www.parkinson.org/sites/default/files/styles/500x360/public/images/SevenTipsBetterSleep-Blog.jpg?h=ed9ce7df&itok=SZuTOvdU) Tips for Daily Living ### [7 Tips for Better Sleep](https://www.parkinson.org/blog/tips/sleep-tips) READ NOW ![Man struggling to read](https://www.parkinson.org/sites/default/files/styles/500x360/public/images/newnonmotor-bloghero_0.png?h=ed9ce7df&itok=XWyb3t0B) Tips for Daily Living ### [Non-motor Symptoms: What’s New? Part 1](https://www.parkinson.org/blog/tips/nonmotor-symptoms1) READ NOW ### Connect with Others Explore our PD Conversations discussion groups to find answers or talk to others going through similar experiences. [Join Now](https://www.pdconversations.org/) - Share on Facebook - Share on X - Share on LinkedIn [Print]() Back to Top Be the First to Know Get the latest news about PD research, resources and community initiatives — straight to your inbox. FL: 5757 Waterford District Drive, Ste 310, Miami, FL 33126 NY: 1350 Broadway, Ste 1530, New York, NY 10018 [Call our Helpline: 1-800-4PD-INFO (473-4636)](https://www.parkinson.org/helpline) [Call our Helpline: 1-800-4PD-INFO (473-4636)](tel:18004734636) CONNECT WITH US - [facebook](https://www.facebook.com/parkinsondotorg) - [instagram](https://www.instagram.com/parkinsondotorg) - [youtube](https://www.youtube.com/channel/UCZYwe6WjTuyLWkYjLH_MQPA) - [linkedin](https://www.linkedin.com/company/parkinsondotorg) - [x-social](https://x.com/parkinsondotorg) - [tiktok](https://www.tiktok.com/@parkinsondotorg) - [Press Room](https://www.parkinson.org/about-us/press-room) - [Online Community](https://www.pdconversations.org/s/) - [Online Store](https://www.parkinson.org/resources-support/pd-library/order-publications) - [Careers](https://www.parkinson.org/about-us/careers) - [PD Library](https://www.parkinson.org/resources-support/pd-library) - [Privacy & Terms](https://www.parkinson.org/privacy) - [Contact Us](https://www.parkinson.org/about-us/contact) - [Supporter Center](https://secure3.convio.net/prkorg/site/SPageNavigator/supporter_center.html) - [![Charity Navigator Logo](https://www.parkinson.org/sites/default/files/styles/footer_badge/public/2025-01/Badge_1.png?itok=hNXi_uKQ)](https://www.charitynavigator.org/ein/131866796) - [![GuideStar Candid Platinum Transparency seal 2026](https://www.parkinson.org/sites/default/files/styles/footer_badge/public/2026-02/badge_5.new_.png?itok=W0aytpnb)](https://app.candid.org/profile/6908528/parkinsons-foundation-13-1866796) - [![BBB Badge](https://www.parkinson.org/sites/default/files/styles/footer_badge/public/2022-03/badge-4.png?itok=9xnIZLpo)](https://give.org/charity-reviews/national/Health/Parkinsons-Foundation-in-Miami-fl-52283) © 2026 Parkinson's Foundation The Parkinson's Foundation is a 501(c)(3) nonprofit organization. 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## 💡 Quick Summary - Fatigue is a common and disabling symptom of Parkinson’s disease, affecting physical and mental energy. - It is distinct from sleepiness and can occur at any stage of Parkinson’s, often worsening with stress, [depression](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/depression "Depression"), pain or medication side effects. - Causes are complex and not fully understood, but fatigue may result from a combination of PD-related brain changes, other medical conditions or medication side effects; identifying and addressing these contributors is key. - Managing fatigue involves lifestyle and behavioral strategies. ![Man rubbing his eyes with the back of his hand](https://www.parkinson.org/sites/default/files/styles/no_sizing/public/images/fatigue.jpg?itok=PJuH1IsV) Do you or a loved one with Parkinson’s disease (PD) feel physically or mentally exhausted? This could be fatigue ― a feeling of deep tiredness that does not improve with rest. About half of people with PD report that fatigue is a major problem and one third say it is their most disabling symptom. Fatigue is different from sleepiness. A person who is fatigued feels exhausted, however, does not necessarily feel like sleeping. **Fatigue symptoms include:** - Physical fatigue: feeling deeply tired or weary ― this may worsen with “off” fluctuations. - Mental fatigue: mental tiredness that makes it difficult to concentrate. Fatigue is common early in the course of PD, but can occur at any point and can happen whether movement symptoms are mild or severe. Fatigue can occur on its own or along with other symptoms such as sleep disturbances, pain, or depression. Stress can make fatigue worse. The cause of fatigue in PD is unknown. It is possible that motor symptoms like tremor and stiffness contribute to making muscles tired, but because fatigue occurs even in those with mild motor symptoms, this is probably not the only explanation. It is important to consider that fatigue can have causes outside of Parkinson’s, too. It is important to identify illnesses or medications unrelated to PD that may contribute to fatigue. The impact of fatigue can be severe. Extreme exhaustion that comes with fatigue can lead people to avoid social activities, reduce hours at work, or even retire. Understanding fatigue as a symptom of PD and finding ways to cope with it are essential to maintaining a good quality of life. ## Therapies Few therapies have been tested for fatigue in PD and none have been proven effective against fatigue on its own. Optimizing medications for movement symptoms does not typically help fatigue. Despite this, there are strategies and tips that can help: - When fatigue is mixed with other symptoms, targeting those other symptoms may help a person feel more energetic. For example, treating sleep disturbances can help a person sleep soundly through the night and therefore less fatigued the following day. Treating depression and pain can also be effective in reducing fatigue. - Some medications for PD motor symptoms may contribute to fatigue or make you sleepy. Adjusting doses of these medications may help solve the problem. - Work with your primary care doctor to identify and treat any medical causes of fatigue besides PD, such as anemia, thyroid disease, low blood pressure, sleep apnea, nutritional deficiencies in vitamin D, B vitamins, etc. - Talk with your doctor before taking any vitamins or supplements. These may interact with medications for PD or other disorders. - Talk to your primary care doctor about medications you take that are not for PD — these also may contribute to fatigue. - Although little research has been done to evaluate stimulants like amphetamine salts, your physician may recommend trying a low dose if you are otherwise healthy. Not all doctors support this approach. ### Tips for Coping with Fatigue - [Eat well](https://www.parkinson.org/living-with-parkinsons/management/diet-nutrition "Diet & Nutrition"). - Stay hydrated. - [Exercise](https://www.parkinson.org/living-with-parkinsons/treatment/exercise "Exercise"). Walk, do Tai Chi, dance, cycle, swim, do Yoga or chair Yoga — whatever you enjoy. Fatigue may make it hard to start exercising, but it may make you feel more energetic afterward. If you find it difficult to get going, consider exercising with another person or a group. - Keep a regular sleep schedule. If you have [difficulty sleeping](https://www.parkinson.org/understanding-parkinsons/non-movement-symptoms/sleep-disorders "Sleep Disorders") because of tremor or stiffness, trouble rolling over or needing to use the bathroom, talk to your doctor about these issues. - Take a short nap (10 to 30 minutes) after lunch. Avoid frequent naps, long naps, or napping after 3 p.m. - Stay socially connected. - Pace yourself: plan your day so that you are active at times when you feel most energetic and have a chance to rest when you need to. - Do something fun: visit with an upbeat friend or pursue a hobby. - At work, take regular short breaks. Fatigue has been identified by the PD community as an unmet need. Research to understand and solve fatigue in PD is ongoing. *Page reviewed by Dr. Addie Patterson, Movement Disorders Neurologist at the Norman Fixel Institute for Neurological Diseases at the University of Florida, a Parkinson’s Foundation Center of Excellence.*
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