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| Meta Title | ANTIDEPRESSANT Definition & Meaning - Merriam-Webster |
| Meta Description | The meaning of ANTIDEPRESSANT is used or tending to relieve or prevent depression. How to use antidepressant in a sentence. |
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| Boilerpipe Text | Recent Examples on the Web
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback
.
Adjective
This is a common step because some research suggests certain
antidepressant
medications could blunt psilocybin’s effects.
—
Natalia V. Osipova,
CNN Money
, 28 Mar. 2026
Between 2016 and 2022,
antidepressant
prescriptions for kids aged 12 to 17 rose 69%.
—
John La Puma,
Oc Register
, 26 Mar. 2026
Noun
Before the retreat, Stem came off her
antidepressant
, in consultation with Confluence facilitators as well as her doctor (who Stem said was skeptical of the retreat).
—
Natalia V. Osipova,
CNN Money
, 28 Mar. 2026
The filings Friday cited numerous poignant cases, including that of a 13-year-old girl held at Dilley who tried to take her own life after staff withheld prescribed
antidepressants
and denied her request to join her mother, as reported by the Associated Press.
—
Garance Burke,
Los Angeles Times
, 22 Mar. 2026
See All Example Sentences for
antidepressant |
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Est. 1828
[Dictionary](https://www.merriam-webster.com/dictionary/antidepressant) Definition
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# antidepressant
1 of 2
## [adjective](https://www.merriam-webster.com/dictionary/adjective)
an·ti·de·pres·sant
[ˌan-tē-di-ˈpre-sᵊnt](https://www.merriam-webster.com/dictionary/antidepressant?pronunciation&lang=en_us&dir=a&file=antid02m "How to pronounce antidepressant (audio)")
[ˌan-ˌtī-](https://www.merriam-webster.com/dictionary/antidepressant?pronunciation&lang=en_us&dir=a&file=antide03 "How to pronounce antidepressant (audio)")
[Synonyms of *antidepressant*](https://www.merriam-webster.com/thesaurus/antidepressant)
Simple Definition
A Simple Definition is available from our Learner's Dictionary to help you understand the meaning faster.
**:** used or tending to relieve or prevent depression
antidepressant drugs
antidepressant
2 of 2
## [noun](https://www.merriam-webster.com/dictionary/noun)
**:** an [antidepressant](https://www.merriam-webster.com/dictionary/antidepressant#h1) drug
see [ssri](https://www.merriam-webster.com/dictionary/ssri), [tricyclic antidepressant](https://www.merriam-webster.com/dictionary/tricyclic%20antidepressant)
## Examples of *antidepressant* in a Sentence
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. [Read More](https://www.merriam-webster.com/dictionary/antidepressant) Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. [Send us feedback](https://docs.google.com/forms/d/1GAQr3Kn1cURCVHUA82hAga1Wv8DCH0IuqDLRUrOpN7M/viewform?ts=63f4f653&entry.1515682415=https://www.merriam-webster.com/dictionary%2Fantidepressant).
Adjective
This is a common step because some research suggests certain *antidepressant* medications could blunt psilocybin’s effects.
—
Natalia V. Osipova, *CNN Money*, 28 Mar. 2026
Between 2016 and 2022, *antidepressant* prescriptions for kids aged 12 to 17 rose 69%.
—
John La Puma, *Oc Register*, 26 Mar. 2026
Noun
Before the retreat, Stem came off her *antidepressant*, in consultation with Confluence facilitators as well as her doctor (who Stem said was skeptical of the retreat).
—
Natalia V. Osipova, *CNN Money*, 28 Mar. 2026
The filings Friday cited numerous poignant cases, including that of a 13-year-old girl held at Dilley who tried to take her own life after staff withheld prescribed *antidepressants* and denied her request to join her mother, as reported by the Associated Press.
—
Garance Burke, *Los Angeles Times*, 22 Mar. 2026
[See All Example Sentences for *antidepressant*](https://www.merriam-webster.com/sentences/antidepressant)
## Word History
First Known Use
Adjective
1961, in the meaning defined [above](https://www.merriam-webster.com/dictionary/antidepressant#h1)
Noun
1962, in the meaning defined [above](https://www.merriam-webster.com/dictionary/antidepressant#h2)
Time Traveler
The first known use of *antidepressant* was in 1961
[See more words from the same year](https://www.merriam-webster.com/time-traveler/1961?src=defrecirc-timetraveler-etycard)
## Phrases Containing *antidepressant*
- [tricyclic antidepressant](https://www.merriam-webster.com/dictionary/tricyclic%20antidepressant)
## Rhymes for *antidepressant*
- [preadolescent](https://www.merriam-webster.com/dictionary/preadolescent)
- [acquiescent](https://www.merriam-webster.com/dictionary/acquiescent)
- [adolescent](https://www.merriam-webster.com/dictionary/adolescent)
- [arborescent](https://www.merriam-webster.com/dictionary/arborescent)
- [coalescent](https://www.merriam-webster.com/dictionary/coalescent)
- [convalescent](https://www.merriam-webster.com/dictionary/convalescent)
- [deliquescent](https://www.merriam-webster.com/dictionary/deliquescent)
- [effervescent](https://www.merriam-webster.com/dictionary/effervescent)
- [evanescent](https://www.merriam-webster.com/dictionary/evanescent)
- [incandescent](https://www.merriam-webster.com/dictionary/incandescent)
- [iridescent](https://www.merriam-webster.com/dictionary/iridescent)
- [luminescent](https://www.merriam-webster.com/dictionary/luminescent)
[See All Rhymes for *antidepressant*](https://www.merriam-webster.com/rhymes/perfect/antidepressant)
## Browse Nearby Words
[antidemocratic](https://www.merriam-webster.com/dictionary/antidemocratic)
antidepressant
[antidepression](https://www.merriam-webster.com/dictionary/antidepression)
[See all Nearby Words](https://www.merriam-webster.com/browse/dictionary/a/44)
## Cite this Entry
Style
“Antidepressant.” *Merriam-Webster.com Dictionary*, Merriam-Webster, https://www.merriam-webster.com/dictionary/antidepressant. Accessed 3 Apr. 2026.
[Copy Citation](https://www.merriam-webster.com/dictionary/antidepressant)
## Medical Definition
antidepressant
1 of 2 adjective
an·ti·de·pres·sant
[ˌant-i-di-ˈpres-ᵊnt, ˌan-ˌtī-](https://www.merriam-webster.com/dictionary/antidepressant?pronunciation&lang=en_us&dir=a&file=antid02m "How to pronounce antidepressant (audio)")
variants
also antidepressive
[\-ˈpres-iv](https://www.merriam-webster.com/dictionary/antidepressant?pronunciation&lang=en_us&dir=a&file=antid03m "How to pronounce antidepressant (audio)")
**:** used or tending to relieve or prevent psychological depression **:** relating to, being, or utilizing an [antidepressant](https://www.merriam-webster.com/dictionary/antidepressant#medicalDictionary)
an antidepressant drug
antidepressant treatment
antidepressant
2 of 2 noun
variants also antidepressive
**:** a drug used to treat psychological depression **:** an antidepressant drug
The dual-action *antidepressant* venlafaxine appears to demonstrate superior efficacy and higher rates of remission in severe depression as compared with either SSRIs such as fluoxetine or tricyclic antidepressants.
—
John Mann
, *The New England Journal of Medicine*
called also energizer, psychic energizer, psychostimulant
see [tricyclic antidepressant](https://www.merriam-webster.com/dictionary/tricyclic%20antidepressant#medicalDictionary)
## More from Merriam-Webster on *antidepressant*
Thesaurus: [All synonyms and antonyms for *antidepressant*](https://www.merriam-webster.com/thesaurus/antidepressant)
Nglish: [Translation of *antidepressant* for Spanish Speakers](http://www.nglish.com/spanish/antidepressant)
Britannica.com: [Encyclopedia article about *antidepressant*](https://www.britannica.com/EBchecked/topic/27929/antidepressant)
Last Updated:
29 Mar 2026
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| Readable Markdown | Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. [Read More](https://www.merriam-webster.com/dictionary/antidepressant) Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. [Send us feedback](https://docs.google.com/forms/d/1GAQr3Kn1cURCVHUA82hAga1Wv8DCH0IuqDLRUrOpN7M/viewform?ts=63f4f653&entry.1515682415=https://www.merriam-webster.com/dictionary%2Fantidepressant).
Adjective
This is a common step because some research suggests certain *antidepressant* medications could blunt psilocybin’s effects. — Natalia V. Osipova, *CNN Money*, 28 Mar. 2026 Between 2016 and 2022, *antidepressant* prescriptions for kids aged 12 to 17 rose 69%. — John La Puma, *Oc Register*, 26 Mar. 2026
Noun
Before the retreat, Stem came off her *antidepressant*, in consultation with Confluence facilitators as well as her doctor (who Stem said was skeptical of the retreat). — Natalia V. Osipova, *CNN Money*, 28 Mar. 2026 The filings Friday cited numerous poignant cases, including that of a 13-year-old girl held at Dilley who tried to take her own life after staff withheld prescribed *antidepressants* and denied her request to join her mother, as reported by the Associated Press. — Garance Burke, *Los Angeles Times*, 22 Mar. 2026 [See All Example Sentences for *antidepressant*](https://www.merriam-webster.com/sentences/antidepressant) |
| Shard | 122 (laksa) |
| Root Hash | 12021194709005532322 |
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