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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 110 (from laksa063)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa110.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression","crawl_time":1768953060,"first_indexed_time":1662162765,"http_code":200,"src_unparsed":"com,medicalnewstoday!www,\/articles\/what-is-the-best-medication-for-anxiety-and-depression s443","src_root_hash":"5853625527623639710","history_drop_reason":null,"meta_title":"Anxiety and depression together: How to choose the best medication","meta_descriptions":["Learn about medications that treat both anxiety and depression, and which medications that treat both conditions individually are safe to combine."],"attrs_boilerpipe_text":"Anxiety and depression are two common mental health diagnoses. For some, they occur as comorbidities, meaning they occur at the same time. Many medications treat both conditions, though dosages may differ.\nIt is\nnormal\nto experience\nanxiety\nevery once in a while. Symptoms can include mental distress as well as physical sensations of discomfort. Anxiety disorders develop when anxiety does not lessen as expected, and symptoms may interfere with a person’s daily life. There are multiple types of anxiety disorders.\nDepression\noccurs when an individual experiences symptoms of low mood and changes in motivation, sleeping, eating, working, and habits for at least\n2 weeks\n. The individual may feel sad, hopeless, despairing, and possibly irritable, among other symptoms. There are several types of depression.\nThis article will explore how often anxiety and depression occur together, which medications treat both conditions, management tips, and more.\nThe study suggests that among people with these conditions, 62% of those with GAD may also experience MDD in their lifetime, and 59% of people with GAD had experienced an episode of MDD within the prior year.\nThere are two schools of thought about why these conditions often appear together. One theory is that similar biological functions activate anxiety and depression. This may mean that if the\nchemistry in the brain\nis in a condition that allows one condition to develop, it may also allow for the other.\nAnother theory is that anxiety and depression share many of the same symptoms, so it is easy for a person to meet the diagnostic criteria for both conditions.\nSometimes, combining one or more medications to treat anxiety and depression is best. A doctor may prescribe the following medications in addition to an SSRI or SNRI or use them on their own.\nBenzodiazepines\nSSRIs and SNRIs typically take\n2–4 weeks\nto reach full effect. For this reason, a doctor may prescribe a fast-acting benzodiazepine medication for individuals with severe anxiety or\npanic attacks\n.\nBenzodiazepine medications are\nhabit-forming\nmedications, and people should carefully follow their doctor’s advice in taking them. A doctor will generally prescribe them at the lowest possible dosage and only as necessary.\nBenzodiazepines\nwork\nby slowing the transmission of nerve impulses between the brain and the body.\nExamples include:\nalprazolam (Xanax)\nclonazepam (Klonopin)\ndiazepam (Valium)\nlorazepam (Ativan)\nBenzodiazepines can have serious side effects, which may include:\ndepression\nconfusion\neuphoria\nimpaired thinking\nmemory loss\nheadache\nsleepiness\nslurred speech\nblurred vision\nimpaired coordination\nnausea\ngastrointestinal issues\nRegular use of these medications can lead to dependence and side effects such as:\nincreased anxiety\npersonality changes\nweakness\nand\nlethargy\ndrowsiness, sleepiness, and\nfatigue\nnightmares\nheadaches\nrash\nweight gain\naddiction\nBuspirone\nBuspirone\nis an anti-anxiety medication doctors use to treat GAD, commonly at a dosage of\n15–60\nmilligrams. It comes in tablet form, and people usually take it twice daily.\nThis medication is an\nanxiolytic\nand acts on the levels of serotonin and other neurotransmitters in the brain. Anxiolytic is another name for a substance that reduces anxiety levels.\ndizziness\ngastrointestinal issues\nnervousness\nconfusion\nfatigue\ntrouble sleeping\nanger or hostility\nheadache\nweakness\nnumbness\nsweating\nMore serious side effects may also occur, such as:\nrash\nhives\nitching\nswelling of the face, eyes, mouth, throat, tongue, or lips\nirregular heartbeat\nblurry vision\nuncontrollable shaking\nagitation\nfever\nsweating and flushing\nconfusion\nshivering\nseizures\nhallucinations\nloss of coordination\nA person should call a doctor immediately if they experience any of these effects.\nTricyclic antidepressants\nAn older class of antidepressants, tricyclic antidepressants, are still available for use when SSRIs and SNRIs have failed to work. They\nare effective\nin treating anxiety disorders but can have significant side effects.\nExamples\nof tricyclic antidepressants include:\namitriptyline (Elavil)\namoxapine (Asendin)\ntrimipramine (Surmontil)\nimipramine (Tofranil)\ndoxepin (Sinequan)\nnortriptyline (Pamelor)\nSide effects\nof tricyclic antidepressants include:\ndry mouth\nconstipation\nblurred vision\ndrowsiness\nlow blood pressure\nurinary problems\nconfusion\nfainting\nseizures\nirregular heartbeat\nFor a diagnosis of GAD, there are a\nfew things\nthe doctor will look for.\nrestlessness or feeling “keyed up”\nfatigue\ndifficulty concentrating\nirritability\nmuscle tension\ntrouble sleeping\nThe diagnostic criteria state that the person’s symptoms should cause clinically significant distress or impair important functioning, and substance misuse or another medical or mental health condition should not explain them better.\ndepressed mood\ndiminished interest or pleasure\nin most or all activities\nsignificant weight loss or weight gain\nincreased or decreased appetite\ninsomnia or hypersomnia, which is when a person sleeps too much\npsychomotor impairment\nfatigue or loss of energy\nfeelings of worthlessness or excessive guilt\na diminished ability to think or concentrate\nindecisiveness\nrecurrent thoughts of death or\nsuicidal ideation\n, with or without planning or an attempt\nCurrent diagnostic criteria state that a person’s symptoms must cause clinically significant distress in a way that interferes with daily functioning. For a doctor to diagnose a major depressive episode, five or more symptoms should be present most of the day for at least 2 weeks in a row.\nSymptoms must not be due to substance misuse or a medical condition. They should also not be attributable to a condition on the\nschizophrenia\nspectrum, another psychotic disorder, or bereavement.\nDealing with anxiety and depression can be daunting, but several medications and combinations of medications provide effective treatment.\nFor most people, newer SSRIs and SNRIs have fewer side effects while providing clinical results. For some, these medications may not provide relief, and older tricyclic antidepressants may be a better option.\nEarly in treatment, a doctor may also recommend a benzodiazepine if anxiety is a particular challenge. However, these medications are habit-forming and should not be a long-term choice. Instead, they create a bridge while SSRIs and SNRIs take effect.","attrs_markdown":"- Health Conditions\n  ### Health Conditions\n  - [Alzheimer's & Dementia](https:\/\/www.medicalnewstoday.com\/alzheimers-and-dementia)\n  - [Anxiety](https:\/\/www.medicalnewstoday.com\/anxiety)\n  - [Asthma & Allergies](https:\/\/www.medicalnewstoday.com\/asthma-and-allergies)\n  - [Atopic Dermatitis](https:\/\/www.medicalnewstoday.com\/program\/investigating-atopic-dermatitis)\n  - [Breast Cancer](https:\/\/www.medicalnewstoday.com\/breast-cancer)\n  - [Cancer](https:\/\/www.medicalnewstoday.com\/cancer)\n  - [Cardiovascular Health](https:\/\/www.medicalnewstoday.com\/cardiovascular-health)\n  - [COVID-19](https:\/\/www.medicalnewstoday.com\/coronavirus?correlationId=2b137d5a-dcfb-464e-9ea6-72c5a54b4e92)\n  - [Diabetes](https:\/\/www.medicalnewstoday.com\/diabetes)\n  - [Endometriosis](https:\/\/www.medicalnewstoday.com\/endometriosis)\n  - [Environment & Sustainability](https:\/\/www.medicalnewstoday.com\/environment-and-sustainability)\n  - [Exercise & Fitness](https:\/\/www.medicalnewstoday.com\/exercise-and-fitness)\n  - [Eye Health](https:\/\/www.medicalnewstoday.com\/eye-health)\n  - [Headache & Migraine](https:\/\/www.medicalnewstoday.com\/headache-and-migraine)\n  - [Health Equity](https:\/\/www.medicalnewstoday.com\/health-equity)\n  - [HIV & AIDS](https:\/\/www.medicalnewstoday.com\/hiv-and-aids)\n  - [Human Biology](https:\/\/www.medicalnewstoday.com\/human-biology)\n  - [Leukemia](https:\/\/www.medicalnewstoday.com\/leukemia)\n  - [LGBTQIA+](https:\/\/www.medicalnewstoday.com\/LGBTQIA)\n  - [Men's Health](https:\/\/www.medicalnewstoday.com\/mens-health)\n  - [Mental Health](https:\/\/www.medicalnewstoday.com\/mental-health)\n  - [Multiple Sclerosis (MS)](https:\/\/www.medicalnewstoday.com\/multiple-sclerosis)\n  - [Nutrition](https:\/\/www.medicalnewstoday.com\/nutrition)\n  - [Parkinson's Disease](https:\/\/www.medicalnewstoday.com\/parkinsons-disease)\n  - [Psoriasis](https:\/\/www.medicalnewstoday.com\/psoriasis)\n  - 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[AMA: Registered dietitian answers 5 key questions about fiber and weight loss](https:\/\/www.medicalnewstoday.com\/articles\/can-fiber-help-lose-weight-dietitian-answers-5-key-questions)\n  - [Health misinformation and disinformation: How to avoid it](https:\/\/www.medicalnewstoday.com\/articles\/health-misinformation-and-disinformation-how-to-avoid-it)\n  - [Brain health, sleep, diet: 3 health resolutions for 2025](https:\/\/www.medicalnewstoday.com\/articles\/brain-health-sleep-diet-3-health-resolutions-for-2025)\n  - [5 things everyone should know about menopause](https:\/\/www.medicalnewstoday.com\/articles\/5-things-everyone-should-know-about-menopause)\n- Tools\n  ### General Health\n  - [Drugs A-Z](https:\/\/www.medicalnewstoday.com\/drugs)\n  - [Health Hubs](https:\/\/www.medicalnewstoday.com\/articles\/content-hubs)\n  - [Newsletter](https:\/\/www.medicalnewstoday.com\/newsletter)\n  - [Medicare Plans by State](https:\/\/www.medicalnewstoday.com\/about\/health-medicare-state-coverage)\n  \n  ### Health Tools\n  - 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[Content Integrity](https:\/\/www.medicalnewstoday.com\/about\/content-integrity)\n  - [Conscious Language](https:\/\/www.medicalnewstoday.com\/about\/conscious-language)\n  \n  ### Find Community\n  - [Bezzy Breast Cancer](https:\/\/www.bezzybc.com\/lp\/2\/?verzenio&utm_source=mnt&utm_medium=nav-bar-connect)\n  - [Bezzy MS](https:\/\/www.bezzyms.com\/?utm_source=mnt&utm_medium=nav-bar-connect)\n  - [Bezzy Migraine](https:\/\/www.bezzymigraine.com\/?utm_source=mnt&utm_medium=nav-bar-connect)\n  - [Bezzy Psoriasis](https:\/\/www.bezzypsoriasis.com\/?utm_source=mnt&utm_medium=nav-bar-connect)\n  ### Follow Us\n\nSubscribe\n\nExplore more in\n\n- Causes & Risk Factors\n- Home Remedies\n- Management\n- Prognosis\n- Symptoms\n- Treatment\n- Types\n- Complications\n- Related Conditions\n\nAnxiety\n\n#### Related Topics\n- ### Causes & Risk Factors\n  Causes & Risk Factors\n  \n  #### Related Articles\n  - [Causes Overview](https:\/\/www.medicalnewstoday.com\/articles\/323456)\n  - [Dehydration](https:\/\/www.medicalnewstoday.com\/articles\/dehydration-and-anxiety)\n  - [Triggers](https:\/\/www.medicalnewstoday.com\/articles\/326134)\n  - [Caffeine](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-caffeine)\n  - [Long COVID](https:\/\/www.medicalnewstoday.com\/articles\/long-covid-anxiety)\n- ### Home Remedies\n  Home Remedies\n  \n  #### Related Articles\n  - [Home Remedies Overview](https:\/\/www.medicalnewstoday.com\/articles\/322396)\n  - [Homeopathic Treatment](https:\/\/www.medicalnewstoday.com\/articles\/327011)\n  - [Herbs](https:\/\/www.medicalnewstoday.com\/articles\/herbs-for-anxiety)\n  - [Magnesium](https:\/\/www.medicalnewstoday.com\/articles\/best-magnesium-supplements-for-anxiety)\n  - [Melatonin](https:\/\/www.medicalnewstoday.com\/articles\/does-melatonin-help-with-anxiety)\n  - [Passionflower](https:\/\/www.medicalnewstoday.com\/articles\/323795)\n  - [Saffron](https:\/\/www.medicalnewstoday.com\/articles\/saffron-for-anxiety)\n  - [Ear seeds](https:\/\/www.medicalnewstoday.com\/articles\/ear-seeds-for-anxiety)\n  - [Hemp Oil](https:\/\/www.medicalnewstoday.com\/articles\/hemp-oil-for-anxiety)\n  - [Fidget Toys](https:\/\/www.medicalnewstoday.com\/articles\/fidget-toys-for-anxiety)\n  - [Best Supplements](https:\/\/www.medicalnewstoday.com\/articles\/supplements-for-anxiety)\n  - [Weighted Blankets](https:\/\/www.medicalnewstoday.com\/articles\/317037)\n  - [Valerian Root](https:\/\/www.medicalnewstoday.com\/articles\/318088)\n  - [Benadryl](https:\/\/www.medicalnewstoday.com\/articles\/does-benadryl-help-with-anxiety)\n  - [Kratom](https:\/\/www.medicalnewstoday.com\/articles\/best-kratom-for-anxiety)\n  - [Acupuncture](https:\/\/www.medicalnewstoday.com\/articles\/acupuncture-for-anxiety)\n- ### Management\n  Management\n  \n  #### Related Articles\n  - [Management Overview](https:\/\/www.medicalnewstoday.com\/articles\/326115)\n  - [EFT Tapping](https:\/\/www.medicalnewstoday.com\/articles\/326434)\n  - [Without Medication](https:\/\/www.medicalnewstoday.com\/articles\/how-to-treat-anxiety-without-medication)\n  - [How to Stop a Panic Attack](https:\/\/www.medicalnewstoday.com\/articles\/321510)\n  - [4-7-8 Breathing](https:\/\/www.medicalnewstoday.com\/articles\/324417)\n  - [Foods that Help](https:\/\/www.medicalnewstoday.com\/articles\/322652)\n  - [Ease Throat Tightness](https:\/\/www.medicalnewstoday.com\/articles\/how-to-relax-throat-muscles-anxiety)\n  - [Service Dogs](https:\/\/www.medicalnewstoday.com\/articles\/322784)\n  - [Sour Candy for Panic Attacks](https:\/\/www.medicalnewstoday.com\/articles\/sour-candy-and-anxiety)\n  - [Breathing Exercises](https:\/\/www.medicalnewstoday.com\/articles\/breathing-exercises-for-anxiety)\n  - [Journaling](https:\/\/www.medicalnewstoday.com\/articles\/how-to-journal-for-anxiety)\n  - [Disability Benefits](https:\/\/www.medicalnewstoday.com\/articles\/is-anxiety-a-disability)\n  - [Exercises](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-exercises)\n  - [333 Rule](https:\/\/www.medicalnewstoday.com\/articles\/333-rule)\n  - [Mindfulness Meditation](https:\/\/www.medicalnewstoday.com\/articles\/mindfulness-meditation-for-anxiety)\n  - [Box Breathing](https:\/\/www.medicalnewstoday.com\/articles\/318973)\n  - [Support Groups](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-support-groups)\n  - [Coping Tips](https:\/\/www.medicalnewstoday.com\/articles\/7603)\n  - [Best Books](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-books)\n  - [Mantras](https:\/\/www.medicalnewstoday.com\/articles\/mantras-for-anxiety)\n  - [Support During Panic Attack](https:\/\/www.medicalnewstoday.com\/articles\/how-to-help-someone-who-is-having-a-panic-attack)\n  - [Coping Methods](https:\/\/www.medicalnewstoday.com\/articles\/how-to-cope-with-anxiety)\n  - [Yoga](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-yoga)\n  - [In Black Communities](https:\/\/www.medicalnewstoday.com\/articles\/black-anxiety)\n  - [Drawing](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-drawing)\n  - [Best Jobs](https:\/\/www.medicalnewstoday.com\/articles\/jobs-for-people-with-anxiety)\n  - [Affirmations](https:\/\/www.medicalnewstoday.com\/articles\/affirmations-for-anxiety)\n  - [Sleep Tips](https:\/\/www.medicalnewstoday.com\/articles\/how-to-fall-asleep-with-anxiety)\n  - [Support for Children](https:\/\/www.medicalnewstoday.com\/articles\/how-to-help-kids-with-anxiety)\n- ### Prognosis\n  Prognosis\n  \n  #### Related Articles\n  - [Outlook Overview](https:\/\/www.medicalnewstoday.com\/articles\/how-long-does-anxiety-last)\n  - [Is It Fatal?](https:\/\/www.medicalnewstoday.com\/articles\/can-you-die-from-a-panic-attack)\n  - [What Makes It Worse](https:\/\/www.medicalnewstoday.com\/articles\/why-is-my-anxiety-so-bad)\n  - [Does Everyone Have Anxiety?](https:\/\/www.medicalnewstoday.com\/articles\/does-everyone-have-anxiety)\n- ### Symptoms\n  Symptoms\n  \n  #### Related Articles\n  - [Symptoms Overview](https:\/\/www.medicalnewstoday.com\/articles\/322510)\n  - [Anxiety-Avoidance Cycle](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-avoidance)\n  - [Shortness of Breath](https:\/\/www.medicalnewstoday.com\/articles\/326831)\n  - [Anxiety Attack](https:\/\/www.medicalnewstoday.com\/articles\/307863)\n  - [Dizziness](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-dizziness)\n  - [Brain Fog](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-brain-fog)\n  - [Rash](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-rash)\n  - [Itching](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-itching)\n  - [Jaw Tension](https:\/\/www.medicalnewstoday.com\/articles\/jaw-tension-anxiety)\n  - [Panic vs. Anxiety Attack](https:\/\/www.medicalnewstoday.com\/articles\/321798)\n  - [Facial Numbness](https:\/\/www.medicalnewstoday.com\/articles\/facial-numbness-and-anxiety)\n  - [Lip Biting](https:\/\/www.medicalnewstoday.com\/articles\/322093)\n  - [Heart Palpitations](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-with-heart-palpitations)\n  - [Shaking](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-shaking)\n  - [Numbness](https:\/\/www.medicalnewstoday.com\/articles\/can-anxiety-cause-numbness)\n  - [Fatigue](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-fatigue)\n  - [Physical Symptoms](https:\/\/www.medicalnewstoday.com\/articles\/physical-symptoms-of-anxiety)\n  - [Appetite Changes](https:\/\/www.medicalnewstoday.com\/articles\/327437)\n  - [Headache](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-headaches)\n  - [Nervous Breakdown](https:\/\/www.medicalnewstoday.com\/articles\/321018)\n  - [Tongue Tingling](https:\/\/www.medicalnewstoday.com\/articles\/tingling-tongue-and-anxiety)\n  - [Nausea](https:\/\/www.medicalnewstoday.com\/articles\/326391)\n- ### Treatment\n  Treatment\n  \n  #### Related Articles\n  - [Treatment Overview](https:\/\/www.medicalnewstoday.com\/articles\/323494)\n  - [Anxiety Medications](https:\/\/www.medicalnewstoday.com\/articles\/323666)\n  - [Beta-Blockers](https:\/\/www.medicalnewstoday.com\/articles\/326397)\n  - [Medication for Anxiety and Depression](https:\/\/www.medicalnewstoday.com\/articles\/which-medications-are-best-for-anxiety-and-depression)\n  - [Xanax](https:\/\/www.medicalnewstoday.com\/articles\/drugs-xanax)\n  - [Ativan](https:\/\/www.medicalnewstoday.com\/articles\/326015)\n  - [Propranolol](https:\/\/www.medicalnewstoday.com\/articles\/how-quickly-does-propranolol-work-for-anxiety)\n  - [Hydroxyzine](https:\/\/www.medicalnewstoday.com\/articles\/drugs-hydroxyzine-oral-tablet)\n  - [Clonazepam](https:\/\/www.medicalnewstoday.com\/articles\/clonazepam-oral-tablet)\n  - [Diazepam](https:\/\/www.medicalnewstoday.com\/articles\/diazepam-oral-tablet)\n  - [Ketamine](https:\/\/www.medicalnewstoday.com\/articles\/ketamine-for-anxiety)\n  - [Buspar](https:\/\/www.medicalnewstoday.com\/articles\/buspar-side-effects)\n  - [Social Anxiety Medication](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-social-anxiety)\n  - [Antipsychotics](https:\/\/www.medicalnewstoday.com\/articles\/antipsychotics-for-anxiety)\n  - [Transcranial Magnetic Stimulation](https:\/\/www.medicalnewstoday.com\/articles\/tms-for-anxiety)\n  - [Best Online CBT Platforms](https:\/\/www.medicalnewstoday.com\/articles\/cbt-for-anxiety)\n- ### Types\n  Types\n  \n  #### Related Articles\n  - [Types Overview](https:\/\/www.medicalnewstoday.com\/articles\/how-to-overcome-anxiety)\n  - [In the Morning](https:\/\/www.medicalnewstoday.com\/articles\/325808)\n  - [Separation](https:\/\/www.medicalnewstoday.com\/articles\/322070)\n  - [Driving](https:\/\/www.medicalnewstoday.com\/articles\/driving-anxiety)\n  - [Anticipatory](https:\/\/www.medicalnewstoday.com\/articles\/anticipatory-anxiety)\n  - [Debilitating](https:\/\/www.medicalnewstoday.com\/articles\/debilitating-anxiety)\n  - [Parental](https:\/\/www.medicalnewstoday.com\/articles\/parental-anxiety)\n  - [Hyperstimulation](https:\/\/www.medicalnewstoday.com\/articles\/hyperstimulation-anxiety)\n  - [Panic Disorder](https:\/\/www.medicalnewstoday.com\/articles\/8872)\n  - [Generalized Anxiety Disorder](https:\/\/www.medicalnewstoday.com\/articles\/326416)\n  - [Existential](https:\/\/www.medicalnewstoday.com\/articles\/existential-anxiety)\n  - [Travel](https:\/\/www.medicalnewstoday.com\/articles\/travel-anxiety)\n  - [Social](https:\/\/www.medicalnewstoday.com\/articles\/176891)\n  - [Trait vs. State Anxiety](https:\/\/www.medicalnewstoday.com\/articles\/trait-anxiety)\n  - [Situational](https:\/\/www.medicalnewstoday.com\/articles\/situational-anxiety)\n  - [Political](https:\/\/www.medicalnewstoday.com\/articles\/political-anxiety)\n  - [Hospital](https:\/\/www.medicalnewstoday.com\/articles\/hospital-anxiety)\n  - [Types of Social Anxiety](https:\/\/www.medicalnewstoday.com\/articles\/types-of-social-anxiety)\n  - [Eco-Anxiety](https:\/\/www.medicalnewstoday.com\/articles\/327354)\n  - [Pathological](https:\/\/www.medicalnewstoday.com\/articles\/pathological-anxiety-definition-causes-and-symptoms)\n  - [Free-Floating](https:\/\/www.medicalnewstoday.com\/articles\/free-floating-anxiety)\n  - [Anxiety Disorders](https:\/\/www.medicalnewstoday.com\/articles\/types-of-anxiety)\n  - [Anxiety in Children](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-in-children)\n  - [High Functioning](https:\/\/www.medicalnewstoday.com\/articles\/high-functioning-anxiety)\n  - [Health](https:\/\/www.medicalnewstoday.com\/articles\/health-anxiety)\n  - [Before Period](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-before-period)\n  - [Dating](https:\/\/www.medicalnewstoday.com\/articles\/dating-anxiety)\n  - [School](https:\/\/www.medicalnewstoday.com\/articles\/school-anxiety)\n  - [Friendship](https:\/\/www.medicalnewstoday.com\/articles\/friendship-anxiety)\n  - [Surgery](https:\/\/www.medicalnewstoday.com\/articles\/surgery-anxiety)\n  - [At Night](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-at-night)\n  - [Dental](https:\/\/www.medicalnewstoday.com\/articles\/what-to-know-about-dental-anxiety)\n  - [In Males](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-in-men-fighting-stereotypes)\n  - [Hangover](https:\/\/www.medicalnewstoday.com\/articles\/hangover-anxiety)\n  - [Test](https:\/\/www.medicalnewstoday.com\/articles\/test-anxiety-tips)\n  - [Gym](https:\/\/www.medicalnewstoday.com\/articles\/gym-anxiety)\n- ### Complications\n  Complications\n  \n  #### Related Articles\n  - [Left Arm Pain](https:\/\/www.medicalnewstoday.com\/articles\/left-arm-pain-from-anxiety)\n  - [Hot Flashes](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-hot-flashes)\n  - [Acid Reflux](https:\/\/www.medicalnewstoday.com\/articles\/acid-reflux-and-anxiety)\n  - [Anxiety Poop](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-poop)\n  - [Atrial Fibrillation](https:\/\/www.medicalnewstoday.com\/articles\/can-anxiety-cause-atrial-fibrillation)\n  - [Inflammation](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-and-inflammation-is-there-a-link)\n  - [Anxiety Dreams](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-dreams)\n- ### Related Conditions\n  Related Conditions\n  \n  #### Related Articles\n  - [Vs. Depression](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-vs-depression)\n  - [Psychosis](https:\/\/www.medicalnewstoday.com\/articles\/anxiety-psychosis)\n  - [Vs. Stress](https:\/\/www.medicalnewstoday.com\/articles\/stress-vs-anxiety)\n  - [Tinnitus](https:\/\/www.medicalnewstoday.com\/articles\/ringing-in-ears-anxiety)\n  - [Panic vs. Heart Attack](https:\/\/www.medicalnewstoday.com\/articles\/322797)\n  - [AVPD vs. Social Anxiety](https:\/\/www.medicalnewstoday.com\/articles\/avpd-vs-social-anxiety)\n  - [Vs. Paranoia](https:\/\/www.medicalnewstoday.com\/articles\/paranoia-vs-anxiety)\n  - [Adjustment Disorder](https:\/\/www.medicalnewstoday.com\/articles\/adjustment-disorder-with-anxiety)\n\n# How to choose the best medication for anxiety alongside depression\n![](https:\/\/i0.wp.com\/post.medicalnewstoday.com\/wp-content\/uploads\/sites\/3\/2021\/04\/Nicole_Washington_500x500_Med_Reviewer_Photos_v2.png?w=105&h=105)\n\n[Medically reviewed]() by [Nicole Washington, DO, MPH]() — Written by [Karen Veazey]()  on August 30, 2022\n\n- [Prevalence](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#prevalence)\n- [Medications for both](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#medications-for-both)\n- [Combining medications safely](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#combining-medications-safely)\n- [Diagnosing anxiety](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#diagnosing-anxiety)\n- [Diagnosing depression](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#diagnosing-depression)\n- [Management tips](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#management-tips)\n- [Summary](https:\/\/www.medicalnewstoday.com\/articles\/what-is-the-best-medication-for-anxiety-and-depression#summary)\n\nAnxiety and depression are two common mental health diagnoses. For some, they occur as comorbidities, meaning they occur at the same time. Many medications treat both conditions, though dosages may differ.\n\nIt is [normal](https:\/\/www.nimh.nih.gov\/health\/topics\/anxiety-disorders) to experience [anxiety](https:\/\/www.medicalnewstoday.com\/articles\/323454) every once in a while. Symptoms can include mental distress as well as physical sensations of discomfort. Anxiety disorders develop when anxiety does not lessen as expected, and symptoms may interfere with a person’s daily life. There are multiple types of anxiety disorders.\n\n[Depression](https:\/\/www.medicalnewstoday.com\/articles\/8933) occurs when an individual experiences symptoms of low mood and changes in motivation, sleeping, eating, working, and habits for at least [2 weeks](https:\/\/www.nimh.nih.gov\/health\/topics\/depression). The individual may feel sad, hopeless, despairing, and possibly irritable, among other symptoms. There are several types of depression.\n\nThis article will explore how often anxiety and depression occur together, which medications treat both conditions, management tips, and more.\n\n## [Prevalence of depression and anxiety]()\n![glass vials containing medication for depression and anxiety together](https:\/\/i0.wp.com\/post.medicalnewstoday.com\/wp-content\/uploads\/sites\/3\/2022\/07\/medication_depression_GettyImages1277352642_Header-1024x575.jpg?w=1155&h=1528)\n\n[Share on Pinterest](https:\/\/www.pinterest.com\/pin\/create\/button\/?url=https%3A%2F%2Fwww.medicalnewstoday.com%2Farticles%2Fwhat-is-the-best-medication-for-anxiety-and-depression&media=https%3A%2F%2Fpost.medicalnewstoday.com%2Fwp-content%2Fuploads%2Fsites%2F3%2F2022%2F07%2Fmedication_depression_GettyImages1277352642_Header-1024x575.jpg&description=Anxiety%20and%20depression%20together%3A%20How%20to%20choose%20the%20best%20medication \"Share on Pinterest\")\n\nBloomberg Creative\/Getty Images\n\nA 2015 study published in the *World Journal of Psychiatry* states that [generalized anxiety disorder (GAD)](https:\/\/www.medicalnewstoday.com\/articles\/326416) is the [most common](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4694550\/) anxiety disorder. [Major depressive disorder (MDD)](https:\/\/www.medicalnewstoday.com\/articles\/major-depressive-disorder-vs-persistent-depressive-disorder) is the most common depressive disorder.\n\nThe study suggests that among people with these conditions, 62% of those with GAD may also experience MDD in their lifetime, and 59% of people with GAD had experienced an episode of MDD within the prior year.\n\nThere are two schools of thought about why these conditions often appear together. One theory is that similar biological functions activate anxiety and depression. This may mean that if the [chemistry in the brain](https:\/\/www.medicalnewstoday.com\/articles\/326475) is in a condition that allows one condition to develop, it may also allow for the other.\n\nAnother theory is that anxiety and depression share many of the same symptoms, so it is easy for a person to meet the diagnostic criteria for both conditions.\n\n[Learn more about the connection between anxiety, depression, and PTSD.](https:\/\/www.medicalnewstoday.com\/articles\/326903)\n\n## [Medications for anxiety and depression]()\nSeveral types of medication treat both anxiety and depression. These include:\n\n### Selective serotonin reuptake inhibitors\n[Selective serotonin reuptake inhibitors (SSRIs)](https:\/\/www.medicalnewstoday.com\/articles\/ssri-vs-snri) are the drug that doctors [most commonly](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554406\/) prescribe to treat depression and anxiety disorders. They work by increasing the amount of [serotonin](https:\/\/www.medicalnewstoday.com\/articles\/232248), a neurotransmitter or chemical messenger, that circulates in the brain.\n\nSSRIs that doctors prescribe in the US include:\n\n- [fluoxetine (Prozac)](https:\/\/www.medicalnewstoday.com\/articles\/322413)\n- [sertraline (Zoloft)](https:\/\/www.medicalnewstoday.com\/articles\/325632)\n- [paroxetine (Paxil)](https:\/\/www.medicalnewstoday.com\/articles\/325996)\n- fluvoxamine (Luvox)\n- [citalopram (Celexa)](https:\/\/www.medicalnewstoday.com\/articles\/celexa)\n- [escitalopram (Lexapro)](https:\/\/www.medicalnewstoday.com\/articles\/escitalopram-oral-tablet)\n\nDepending on the type of medication, most SSRIs are available in tablet or capsule form. Some may also be available as a liquid.\n\nSSRIs can have a variety of [side effects](https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/side-effects\/), including:\n\n- feeling agitated or nervous\n- gastrointestinal issues\n- [loss of appetite](https:\/\/www.medicalnewstoday.com\/articles\/324011)\n- weight changes\n- [dizziness](https:\/\/www.medicalnewstoday.com\/articles\/319026)\n- [blurred vision](https:\/\/www.medicalnewstoday.com\/articles\/sudden-blurry-vision)\n- [dry mouth](https:\/\/www.medicalnewstoday.com\/articles\/187640)\n- [sweating](https:\/\/www.medicalnewstoday.com\/articles\/182130)\n- [trouble sleeping](https:\/\/www.medicalnewstoday.com\/articles\/327339)\n- [headaches](https:\/\/www.medicalnewstoday.com\/articles\/73936)\n- [sexual dysfunction](https:\/\/www.medicalnewstoday.com\/articles\/315984)\n\nMore serious side effects may include:\n\n- bleeding or [bruising easily](https:\/\/www.medicalnewstoday.com\/articles\/325525)\n- [vomiting blood](https:\/\/www.medicalnewstoday.com\/articles\/314031), which may look like coffee grounds\n- [blood in the stool](https:\/\/www.medicalnewstoday.com\/articles\/blood-in-stool)\n- [confusion](https:\/\/www.medicalnewstoday.com\/articles\/confusion)\n- movement problems\n- [hallucinations](https:\/\/www.medicalnewstoday.com\/articles\/327014)\n- problems urinating\n\nIf any of these serious side effects occur, a person should notify a doctor immediately.\n\n### Serotonin-norepinephrine reuptake inhibitors\nExamples of [serotonin-norepinephrine reuptake inhibitors (SNRIs)](https:\/\/www.medicalnewstoday.com\/articles\/snri) include [venlafaxine (Effexor XR)](https:\/\/www.medicalnewstoday.com\/articles\/326678) and [duloxetine (Cymbalta)](https:\/\/www.medicalnewstoday.com\/articles\/cymbalta). These drugs [are similar](https:\/\/adaa.org\/find-help\/treatment-help\/medication-options) to SSRIs, but SNRIs prevent both serotonin and norepinephrine from being reabsorbed by nerve cells. They typically come in tablet form.\n\nSide effects of SNRIs may include:\n\n- gastrointestinal issues\n- [insomnia](https:\/\/www.medicalnewstoday.com\/articles\/9155)\n- headache\n- sexual dysfunction\n- weight gain\n- a minor [blood pressure](http:\/\/www.medicalnewstoday.com\/articles\/270644) increase\n\n## [Medications people can safely combine]()\nSometimes, combining one or more medications to treat anxiety and depression is best. A doctor may prescribe the following medications in addition to an SSRI or SNRI or use them on their own.\n\n### Benzodiazepines\nSSRIs and SNRIs typically take [2–4 weeks](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4694550\/) to reach full effect. For this reason, a doctor may prescribe a fast-acting benzodiazepine medication for individuals with severe anxiety or [panic attacks](https:\/\/www.medicalnewstoday.com\/articles\/8872).\n\nBenzodiazepine medications are [habit-forming](https:\/\/adaa.org\/find-help\/treatment-help\/medication-options) medications, and people should carefully follow their doctor’s advice in taking them. A doctor will generally prescribe them at the lowest possible dosage and only as necessary.\n\nBenzodiazepines [work](https:\/\/adf.org.au\/drug-facts\/benzodiazepines\/) by slowing the transmission of nerve impulses between the brain and the body.\n\nExamples include:\n\n- [alprazolam (Xanax)](https:\/\/www.medicalnewstoday.com\/articles\/326488)\n- [clonazepam (Klonopin)](https:\/\/www.medicalnewstoday.com\/articles\/clonazepam-oral-tablet)\n- [diazepam (Valium)](https:\/\/www.medicalnewstoday.com\/articles\/diazepam-oral-tablet)\n- [lorazepam (Ativan)](https:\/\/www.medicalnewstoday.com\/articles\/326015)\n\nBenzodiazepines can have serious side effects, which may include:\n\n- depression\n- confusion\n- euphoria\n- impaired thinking\n- memory loss\n- headache\n- sleepiness\n- slurred speech\n- blurred vision\n- impaired coordination\n- [nausea](https:\/\/www.medicalnewstoday.com\/articles\/what-causes-nausea)\n- gastrointestinal issues\n\nRegular use of these medications can lead to dependence and side effects such as:\n\n- increased anxiety\n- personality changes\n- [weakness](https:\/\/www.medicalnewstoday.com\/articles\/asthenia-weakness) and [lethargy](https:\/\/www.medicalnewstoday.com\/articles\/lethargy)\n- drowsiness, sleepiness, and [fatigue](https:\/\/www.medicalnewstoday.com\/articles\/248002)\n- nightmares\n- headaches\n- [rash](https:\/\/www.medicalnewstoday.com\/articles\/317999)\n- weight gain\n- [addiction](https:\/\/www.medicalnewstoday.com\/articles\/323465)\n### Buspirone\n[Buspirone](https:\/\/www.medicalnewstoday.com\/articles\/drugs-buspirone-oral-tablet) is an anti-anxiety medication doctors use to treat GAD, commonly at a dosage of [15–60](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK531477\/) milligrams. It comes in tablet form, and people usually take it twice daily.\n\nThis medication is an [anxiolytic](https:\/\/www.medicalnewstoday.com\/articles\/324015#what-is-kava-kava) and acts on the levels of serotonin and other neurotransmitters in the brain. Anxiolytic is another name for a substance that reduces anxiety levels.\n\n[Side effects](https:\/\/medlineplus.gov\/druginfo\/meds\/a688005.html) of buspirone might include:\n\n- dizziness\n- gastrointestinal issues\n- nervousness\n- confusion\n- fatigue\n- trouble sleeping\n- anger or hostility\n- headache\n- weakness\n- [numbness](https:\/\/www.medicalnewstoday.com\/articles\/326062)\n- sweating\n\nMore serious side effects may also occur, such as:\n\n- rash\n- [hives](https:\/\/www.medicalnewstoday.com\/articles\/157260)\n- itching\n- swelling of the face, eyes, mouth, throat, tongue, or lips\n- [irregular heartbeat](https:\/\/www.medicalnewstoday.com\/articles\/8887)\n- blurry vision\n- uncontrollable shaking\n- agitation\n- [fever](https:\/\/www.medicalnewstoday.com\/articles\/168266)\n- sweating and flushing\n- confusion\n- [shivering](https:\/\/www.medicalnewstoday.com\/articles\/322515)\n- [seizures](https:\/\/www.medicalnewstoday.com\/articles\/seizure)\n- hallucinations\n- loss of coordination\n\nA person should call a doctor immediately if they experience any of these effects.\n\n### Tricyclic antidepressants\nAn older class of antidepressants, tricyclic antidepressants, are still available for use when SSRIs and SNRIs have failed to work. They [are effective](https:\/\/adaa.org\/find-help\/treatment-help\/medication-options) in treating anxiety disorders but can have significant side effects.\n\n[Examples](https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/antidepressants\/overview\/) of tricyclic antidepressants include:\n\n- [amitriptyline (Elavil)](https:\/\/www.medicalnewstoday.com\/articles\/amitriptyline-oral-tablet)\n- amoxapine (Asendin)\n- trimipramine (Surmontil)\n- imipramine (Tofranil)\n- doxepin (Sinequan)\n- nortriptyline (Pamelor)\n\n[Side effects](https:\/\/www.fda.gov\/consumers\/free-publications-women\/depression-medicines#Tricyclic-Tetracyclic) of tricyclic antidepressants include:\n\n- dry mouth\n- [constipation](https:\/\/www.medicalnewstoday.com\/articles\/150322)\n- blurred vision\n- drowsiness\n- [low blood pressure](https:\/\/www.medicalnewstoday.com\/articles\/159609)\n- urinary problems\n- confusion\n- [fainting](https:\/\/www.medicalnewstoday.com\/articles\/182524)\n- seizures\n- irregular heartbeat\n\n## [Diagnostic criteria for anxiety]()\nFor a diagnosis of GAD, there are a [few things](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519704\/table\/ch3.t15\/) the doctor will look for.\n\nAccording to the [*Diagnostic and Statistical Manual of Mental Disorders, 5th edition, text revision* (*DSM-5-TR)*](https:\/\/cks.nice.org.uk\/topics\/generalized-anxiety-disorder\/diagnosis\/diagnosis\/), the individual should find it difficult to control their worry, and the anxiety should associate with at least three of the following symptoms on more days than not for the previous 6 months:\n\n- restlessness or feeling “keyed up”\n- fatigue\n- difficulty concentrating\n- [irritability](https:\/\/www.medicalnewstoday.com\/articles\/325564)\n- [muscle tension](https:\/\/www.medicalnewstoday.com\/articles\/rigid-muscles)\n- trouble sleeping\n\nThe diagnostic criteria state that the person’s symptoms should cause clinically significant distress or impair important functioning, and substance misuse or another medical or mental health condition should not explain them better.\n\n## [Diagnostic criteria for depression]()\nTo [diagnose depression](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519712\/table\/ch3.t5\/), a doctor will look for the following:\n\n- depressed mood\n- [diminished interest or pleasure](https:\/\/www.medicalnewstoday.com\/articles\/320737) in most or all activities\n- significant weight loss or weight gain\n- increased or decreased appetite\n- insomnia or hypersomnia, which is when a person sleeps too much\n- psychomotor impairment\n- fatigue or loss of energy\n- feelings of worthlessness or excessive guilt\n- a diminished ability to think or concentrate\n- indecisiveness\n- recurrent thoughts of death or [suicidal ideation](https:\/\/www.medicalnewstoday.com\/articles\/193026), with or without planning or an attempt\n\nCurrent diagnostic criteria state that a person’s symptoms must cause clinically significant distress in a way that interferes with daily functioning. For a doctor to diagnose a major depressive episode, five or more symptoms should be present most of the day for at least 2 weeks in a row.\n\nSymptoms must not be due to substance misuse or a medical condition. They should also not be attributable to a condition on the [schizophrenia](https:\/\/www.medicalnewstoday.com\/articles\/36942) spectrum, another psychotic disorder, or bereavement.\n\n## [Other tips and treatments]()\nThere are ways a person can try to [manage anxiety and depression](https:\/\/adaa.org\/tips) at home, such as by:\n\n- limiting [alcohol](https:\/\/www.medicalnewstoday.com\/articles\/305062) and [caffeine](https:\/\/www.medicalnewstoday.com\/articles\/285194)\n- getting enough [sleep](https:\/\/www.medicalnewstoday.com\/articles\/sleep-and-mental-health)\n- [exercising](https:\/\/www.medicalnewstoday.com\/articles\/322734) daily\n- [meditating](https:\/\/www.medicalnewstoday.com\/articles\/320392)\n- seeking out humor\n- eating [balanced meals](https:\/\/www.medicalnewstoday.com\/articles\/324093)\n- planning time out to do [yoga](https:\/\/www.medicalnewstoday.com\/articles\/286745), get a [massage](https:\/\/www.medicalnewstoday.com\/articles\/317675), or practice [deep breathing techniques](https:\/\/www.medicalnewstoday.com\/articles\/breathing-techniques) to clear the mind\n- volunteering\n- learning about anxiety and depression\n- talking with a trusted person about thoughts and feelings\n\n**»MORE:**[Get a refill for your medication in as little as 15 minutes with Optum Now Online Care.](https:\/\/now.optum.com\/online-care\/prescription-refill?utm_source=mnt&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-rxrefill&utm_campaign=mnt-article-oc-on-backlink%20%20%20%20)\n\nOptum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https:\/\/www.medicalnewstoday.com\/about\/brand-and-product-vetting)\n\n## [Summary]()\nDealing with anxiety and depression can be daunting, but several medications and combinations of medications provide effective treatment.\n\nFor most people, newer SSRIs and SNRIs have fewer side effects while providing clinical results. For some, these medications may not provide relief, and older tricyclic antidepressants may be a better option.\n\nEarly in treatment, a doctor may also recommend a benzodiazepine if anxiety is a particular challenge. However, these medications are habit-forming and should not be a long-term choice. Instead, they create a bridge while SSRIs and SNRIs take effect.\n\n- [Depression](https:\/\/www.medicalnewstoday.com\/categories\/depression)\n- [Anxiety \/ Stress](https:\/\/www.medicalnewstoday.com\/categories\/anxiety)\n- [Drugs](https:\/\/www.medicalnewstoday.com\/categories\/drugs)\n\n### How we reviewed this article:\nSources\n\nMedical News Today has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https:\/\/www.medicalnewstoday.com\/articles\/process).\n\n- Anxiety disorders. (2022).  \n  <https:\/\/www.nimh.nih.gov\/health\/topics\/anxiety-disorders>\n- Benzodiazepines. (2022).  \n  <https:\/\/adf.org.au\/drug-facts\/benzodiazepines\/>\n- Buspirone. (2019).  \n  <https:\/\/medlineplus.gov\/druginfo\/meds\/a688005.html>\n- Chapter 3.3.1. Major depressive episode\/disorder. *DSM-5 Changes: Implications for Child Serious Emotional Disturbance.* (2016).  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519712>\n- Chapter 3.3.9. Generalized anxiety disorder (MHSS). *Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health*. (2016).  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519704>\n- Chu, A., *et. al.*, (2022). Selective serotonin reuptake inhibitors.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554406\/>\n- Coplan, J. D., *et. al.* (2015). Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4694550\/>\n- Depression. (2022).  \n  <https:\/\/www.nimh.nih.gov\/health\/topics\/depression>\n- Depression medicines. (2019).  \n  <https:\/\/www.fda.gov\/consumers\/free-publications-women\/depression-medicines#Tricyclic-Tetracyclic>\n- Ellen, S., *et. al*. (2017). Depression and anxiety: Pharmacological treatment in general practice.  \n  <https:\/\/www.racgp.org.au\/getattachment\/87865c41-fdd7-4eb1-8920-cb0c7f02d8a9\/attachment.aspx>\n- Medication options. (2019).  \n  <https:\/\/adaa.org\/find-help\/treatment-help\/medication-options>\n- Side effects: Selective serotonin reuptake inhibitors (SSRIs). (2021).  \n  <https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/side-effects\/>\n- Tips and strategies to manage anxiety and stress. (2022).  \n  <https:\/\/adaa.org\/tips>\n- When should I suspect generalized anxiety disorder? (2022).  \n  <https:\/\/cks.nice.org.uk\/topics\/generalized-anxiety-disorder\/diagnosis\/diagnosis\/>\n- Wilson, T. K., *et. al.* (2022). Buspirone.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK531477\/>\n\nShare this article\n\n![](https:\/\/i0.wp.com\/post.medicalnewstoday.com\/wp-content\/uploads\/sites\/3\/2021\/04\/Nicole_Washington_500x500_Med_Reviewer_Photos_v2.png?w=105&h=105)\n\n[Medically reviewed]() by [Nicole Washington, DO, MPH]() — Written by [Karen Veazey]()  on August 30, 2022\n\n## Latest news\n- [US vaccine guideline changes challenge clinical practice, insurance coverage](https:\/\/www.medicalnewstoday.com\/articles\/us-vaccine-changes-challenge-clinical-practice-insurance-coverage)\n- [Exercise prevents muscle loss as we age: Here's how](https:\/\/www.medicalnewstoday.com\/articles\/exercise-prevents-muscle-loss-aging-how-protein-biology)\n- [Moving just 5 more minutes each day could boost longevity](https:\/\/www.medicalnewstoday.com\/articles\/moving-just-5-more-minutes-each-day-could-boost-longevity)\n- [New Mount Sinai AI tool aims to improve access to cancer clinical trials](https:\/\/www.medicalnewstoday.com\/articles\/mount-sinai-ai-tool-aims-to-improve-access-to-cancer-clinical-trials)\n- [Early menopause not linked to higher diabetes risk, study finds](https:\/\/www.medicalnewstoday.com\/articles\/early-menopause-not-linked-higher-type-2-diabetes-risk)\n\n### Related Coverage\n- [What are the best medications to treat generalized anxiety disorder?](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext)\n  \n  [Doctors may prescribe medications such as antidepressants to treat generalized anxiety disorder. Learn more here.](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext)\n- [How to safely medicate for anxiety alongside heart issues](https:\/\/www.medicalnewstoday.com\/articles\/best-anxiety-medication-for-heart-patients?utm_source=ReadNext)\n  \n  Medically reviewed by [Nicole Washington, DO, MPH](https:\/\/www.medicalnewstoday.com\/reviewers)\n  \n  [Anxiety and heart conditions may occur together. Learn about the best anxiety medications for heart patients, how they work, and possible side effects](https:\/\/www.medicalnewstoday.com\/articles\/best-anxiety-medication-for-heart-patients?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.medicalnewstoday.com\/articles\/best-anxiety-medication-for-heart-patients?utm_source=ReadNext)\n- [What are the best medications for depression, anxiety, and ADHD?](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-anxiety-depression-and-adhd?utm_source=ReadNext)\n  \n  [Doctors prescribe a range of medications, such as SSRIs and SNRIs, to treat mental health conditions. Learn more.](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-anxiety-depression-and-adhd?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.medicalnewstoday.com\/articles\/best-medication-for-anxiety-depression-and-adhd?utm_source=ReadNext)\n- [Exercise may reduce depression symptoms as effectively as therapy](https:\/\/www.medicalnewstoday.com\/articles\/exercise-may-reduce-depression-symptoms-as-effectively-as-therapy?utm_source=ReadNext)\n  \n  [Getting enough exercise, especially light to moderate intensity, may help reduce depression symptoms as effectively as psychological therapy, a new…](https:\/\/www.medicalnewstoday.com\/articles\/exercise-may-reduce-depression-symptoms-as-effectively-as-therapy?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.medicalnewstoday.com\/articles\/exercise-may-reduce-depression-symptoms-as-effectively-as-therapy?utm_source=ReadNext)\n- [Seasonal slump or mental health myth? The truth about Blue Monday](https:\/\/www.medicalnewstoday.com\/articles\/mental-health-myth-blue-monday-depression-sad-january?utm_source=ReadNext)\n  \n  [Blue Monday, the most depressing day of the year: Is there any science behind it, or is it just a myth that has gained too much momentum over time?](https:\/\/www.medicalnewstoday.com\/articles\/mental-health-myth-blue-monday-depression-sad-january?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.medicalnewstoday.com\/articles\/mental-health-myth-blue-monday-depression-sad-january?utm_source=ReadNext)\n\n© 2026 Healthline Media UK Ltd, London, UK. All rights reserved. MNT is the registered trade mark of Healthline Media. Healthline Media is an RVO Health Company. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. 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Meta Title	Anxiety and depression together: How to choose the best medication
Meta Description	Learn about medications that treat both anxiety and depression, and which medications that treat both conditions individually are safe to combine.
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Boilerpipe Text	Anxiety and depression are two common mental health diagnoses. For some, they occur as comorbidities, meaning they occur at the same time. Many medications treat both conditions, though dosages may differ. It is normal to experience anxiety every once in a while. Symptoms can include mental distress as well as physical sensations of discomfort. Anxiety disorders develop when anxiety does not lessen as expected, and symptoms may interfere with a person’s daily life. There are multiple types of anxiety disorders. Depression occurs when an individual experiences symptoms of low mood and changes in motivation, sleeping, eating, working, and habits for at least 2 weeks . The individual may feel sad, hopeless, despairing, and possibly irritable, among other symptoms. There are several types of depression. This article will explore how often anxiety and depression occur together, which medications treat both conditions, management tips, and more. The study suggests that among people with these conditions, 62% of those with GAD may also experience MDD in their lifetime, and 59% of people with GAD had experienced an episode of MDD within the prior year. There are two schools of thought about why these conditions often appear together. One theory is that similar biological functions activate anxiety and depression. This may mean that if the chemistry in the brain is in a condition that allows one condition to develop, it may also allow for the other. Another theory is that anxiety and depression share many of the same symptoms, so it is easy for a person to meet the diagnostic criteria for both conditions. Sometimes, combining one or more medications to treat anxiety and depression is best. A doctor may prescribe the following medications in addition to an SSRI or SNRI or use them on their own. Benzodiazepines SSRIs and SNRIs typically take 2–4 weeks to reach full effect. For this reason, a doctor may prescribe a fast-acting benzodiazepine medication for individuals with severe anxiety or panic attacks . Benzodiazepine medications are habit-forming medications, and people should carefully follow their doctor’s advice in taking them. A doctor will generally prescribe them at the lowest possible dosage and only as necessary. Benzodiazepines work by slowing the transmission of nerve impulses between the brain and the body. Examples include: alprazolam (Xanax) clonazepam (Klonopin) diazepam (Valium) lorazepam (Ativan) Benzodiazepines can have serious side effects, which may include: depression confusion euphoria impaired thinking memory loss headache sleepiness slurred speech blurred vision impaired coordination nausea gastrointestinal issues Regular use of these medications can lead to dependence and side effects such as: increased anxiety personality changes weakness and lethargy drowsiness, sleepiness, and fatigue nightmares headaches rash weight gain addiction Buspirone Buspirone is an anti-anxiety medication doctors use to treat GAD, commonly at a dosage of 15–60 milligrams. It comes in tablet form, and people usually take it twice daily. This medication is an anxiolytic and acts on the levels of serotonin and other neurotransmitters in the brain. Anxiolytic is another name for a substance that reduces anxiety levels. dizziness gastrointestinal issues nervousness confusion fatigue trouble sleeping anger or hostility headache weakness numbness sweating More serious side effects may also occur, such as: rash hives itching swelling of the face, eyes, mouth, throat, tongue, or lips irregular heartbeat blurry vision uncontrollable shaking agitation fever sweating and flushing confusion shivering seizures hallucinations loss of coordination A person should call a doctor immediately if they experience any of these effects. Tricyclic antidepressants An older class of antidepressants, tricyclic antidepressants, are still available for use when SSRIs and SNRIs have failed to work. They are effective in treating anxiety disorders but can have significant side effects. Examples of tricyclic antidepressants include: amitriptyline (Elavil) amoxapine (Asendin) trimipramine (Surmontil) imipramine (Tofranil) doxepin (Sinequan) nortriptyline (Pamelor) Side effects of tricyclic antidepressants include: dry mouth constipation blurred vision drowsiness low blood pressure urinary problems confusion fainting seizures irregular heartbeat For a diagnosis of GAD, there are a few things the doctor will look for. restlessness or feeling “keyed up” fatigue difficulty concentrating irritability muscle tension trouble sleeping The diagnostic criteria state that the person’s symptoms should cause clinically significant distress or impair important functioning, and substance misuse or another medical or mental health condition should not explain them better. depressed mood diminished interest or pleasure in most or all activities significant weight loss or weight gain increased or decreased appetite insomnia or hypersomnia, which is when a person sleeps too much psychomotor impairment fatigue or loss of energy feelings of worthlessness or excessive guilt a diminished ability to think or concentrate indecisiveness recurrent thoughts of death or suicidal ideation , with or without planning or an attempt Current diagnostic criteria state that a person’s symptoms must cause clinically significant distress in a way that interferes with daily functioning. For a doctor to diagnose a major depressive episode, five or more symptoms should be present most of the day for at least 2 weeks in a row. Symptoms must not be due to substance misuse or a medical condition. They should also not be attributable to a condition on the schizophrenia spectrum, another psychotic disorder, or bereavement. Dealing with anxiety and depression can be daunting, but several medications and combinations of medications provide effective treatment. For most people, newer SSRIs and SNRIs have fewer side effects while providing clinical results. For some, these medications may not provide relief, and older tricyclic antidepressants may be a better option. Early in treatment, a doctor may also recommend a benzodiazepine if anxiety is a particular challenge. However, these medications are habit-forming and should not be a long-term choice. Instead, they create a bridge while SSRIs and SNRIs take effect.
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[Magnesium](https://www.medicalnewstoday.com/articles/best-magnesium-supplements-for-anxiety) - [Melatonin](https://www.medicalnewstoday.com/articles/does-melatonin-help-with-anxiety) - [Passionflower](https://www.medicalnewstoday.com/articles/323795) - [Saffron](https://www.medicalnewstoday.com/articles/saffron-for-anxiety) - [Ear seeds](https://www.medicalnewstoday.com/articles/ear-seeds-for-anxiety) - [Hemp Oil](https://www.medicalnewstoday.com/articles/hemp-oil-for-anxiety) - [Fidget Toys](https://www.medicalnewstoday.com/articles/fidget-toys-for-anxiety) - [Best Supplements](https://www.medicalnewstoday.com/articles/supplements-for-anxiety) - [Weighted Blankets](https://www.medicalnewstoday.com/articles/317037) - [Valerian Root](https://www.medicalnewstoday.com/articles/318088) - [Benadryl](https://www.medicalnewstoday.com/articles/does-benadryl-help-with-anxiety) - [Kratom](https://www.medicalnewstoday.com/articles/best-kratom-for-anxiety) - [Acupuncture](https://www.medicalnewstoday.com/articles/acupuncture-for-anxiety) - 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[Exercises](https://www.medicalnewstoday.com/articles/anxiety-exercises) - [333 Rule](https://www.medicalnewstoday.com/articles/333-rule) - [Mindfulness Meditation](https://www.medicalnewstoday.com/articles/mindfulness-meditation-for-anxiety) - [Box Breathing](https://www.medicalnewstoday.com/articles/318973) - [Support Groups](https://www.medicalnewstoday.com/articles/anxiety-support-groups) - [Coping Tips](https://www.medicalnewstoday.com/articles/7603) - [Best Books](https://www.medicalnewstoday.com/articles/anxiety-books) - [Mantras](https://www.medicalnewstoday.com/articles/mantras-for-anxiety) - [Support During Panic Attack](https://www.medicalnewstoday.com/articles/how-to-help-someone-who-is-having-a-panic-attack) - [Coping Methods](https://www.medicalnewstoday.com/articles/how-to-cope-with-anxiety) - [Yoga](https://www.medicalnewstoday.com/articles/anxiety-yoga) - [In Black Communities](https://www.medicalnewstoday.com/articles/black-anxiety) - [Drawing](https://www.medicalnewstoday.com/articles/anxiety-and-drawing) - [Best Jobs](https://www.medicalnewstoday.com/articles/jobs-for-people-with-anxiety) - [Affirmations](https://www.medicalnewstoday.com/articles/affirmations-for-anxiety) - [Sleep Tips](https://www.medicalnewstoday.com/articles/how-to-fall-asleep-with-anxiety) - [Support for Children](https://www.medicalnewstoday.com/articles/how-to-help-kids-with-anxiety) - ### Prognosis Prognosis #### Related Articles - [Outlook Overview](https://www.medicalnewstoday.com/articles/how-long-does-anxiety-last) - [Is It Fatal?](https://www.medicalnewstoday.com/articles/can-you-die-from-a-panic-attack) - [What Makes It Worse](https://www.medicalnewstoday.com/articles/why-is-my-anxiety-so-bad) - [Does Everyone Have Anxiety?](https://www.medicalnewstoday.com/articles/does-everyone-have-anxiety) - ### Symptoms Symptoms #### Related Articles - [Symptoms Overview](https://www.medicalnewstoday.com/articles/322510) - [Anxiety-Avoidance Cycle](https://www.medicalnewstoday.com/articles/anxiety-avoidance) - [Shortness of Breath](https://www.medicalnewstoday.com/articles/326831) - [Anxiety Attack](https://www.medicalnewstoday.com/articles/307863) - [Dizziness](https://www.medicalnewstoday.com/articles/anxiety-and-dizziness) - [Brain Fog](https://www.medicalnewstoday.com/articles/anxiety-and-brain-fog) - [Rash](https://www.medicalnewstoday.com/articles/anxiety-rash) - [Itching](https://www.medicalnewstoday.com/articles/anxiety-itching) - [Jaw Tension](https://www.medicalnewstoday.com/articles/jaw-tension-anxiety) - [Panic vs. Anxiety Attack](https://www.medicalnewstoday.com/articles/321798) - [Facial Numbness](https://www.medicalnewstoday.com/articles/facial-numbness-and-anxiety) - [Lip Biting](https://www.medicalnewstoday.com/articles/322093) - [Heart Palpitations](https://www.medicalnewstoday.com/articles/anxiety-with-heart-palpitations) - [Shaking](https://www.medicalnewstoday.com/articles/anxiety-shaking) - [Numbness](https://www.medicalnewstoday.com/articles/can-anxiety-cause-numbness) - [Fatigue](https://www.medicalnewstoday.com/articles/anxiety-and-fatigue) - [Physical Symptoms](https://www.medicalnewstoday.com/articles/physical-symptoms-of-anxiety) - [Appetite Changes](https://www.medicalnewstoday.com/articles/327437) - [Headache](https://www.medicalnewstoday.com/articles/anxiety-headaches) - [Nervous Breakdown](https://www.medicalnewstoday.com/articles/321018) - [Tongue Tingling](https://www.medicalnewstoday.com/articles/tingling-tongue-and-anxiety) - [Nausea](https://www.medicalnewstoday.com/articles/326391) - ### Treatment Treatment #### Related Articles - [Treatment Overview](https://www.medicalnewstoday.com/articles/323494) - [Anxiety Medications](https://www.medicalnewstoday.com/articles/323666) - [Beta-Blockers](https://www.medicalnewstoday.com/articles/326397) - [Medication for Anxiety and Depression](https://www.medicalnewstoday.com/articles/which-medications-are-best-for-anxiety-and-depression) - [Xanax](https://www.medicalnewstoday.com/articles/drugs-xanax) - [Ativan](https://www.medicalnewstoday.com/articles/326015) - [Propranolol](https://www.medicalnewstoday.com/articles/how-quickly-does-propranolol-work-for-anxiety) - [Hydroxyzine](https://www.medicalnewstoday.com/articles/drugs-hydroxyzine-oral-tablet) - [Clonazepam](https://www.medicalnewstoday.com/articles/clonazepam-oral-tablet) - [Diazepam](https://www.medicalnewstoday.com/articles/diazepam-oral-tablet) - [Ketamine](https://www.medicalnewstoday.com/articles/ketamine-for-anxiety) - [Buspar](https://www.medicalnewstoday.com/articles/buspar-side-effects) - [Social Anxiety Medication](https://www.medicalnewstoday.com/articles/best-medication-for-social-anxiety) - [Antipsychotics](https://www.medicalnewstoday.com/articles/antipsychotics-for-anxiety) - [Transcranial Magnetic Stimulation](https://www.medicalnewstoday.com/articles/tms-for-anxiety) - [Best Online CBT Platforms](https://www.medicalnewstoday.com/articles/cbt-for-anxiety) - ### Types Types #### Related Articles - [Types Overview](https://www.medicalnewstoday.com/articles/how-to-overcome-anxiety) - [In the Morning](https://www.medicalnewstoday.com/articles/325808) - [Separation](https://www.medicalnewstoday.com/articles/322070) - [Driving](https://www.medicalnewstoday.com/articles/driving-anxiety) - [Anticipatory](https://www.medicalnewstoday.com/articles/anticipatory-anxiety) - [Debilitating](https://www.medicalnewstoday.com/articles/debilitating-anxiety) - [Parental](https://www.medicalnewstoday.com/articles/parental-anxiety) - [Hyperstimulation](https://www.medicalnewstoday.com/articles/hyperstimulation-anxiety) - [Panic Disorder](https://www.medicalnewstoday.com/articles/8872) - [Generalized Anxiety Disorder](https://www.medicalnewstoday.com/articles/326416) - [Existential](https://www.medicalnewstoday.com/articles/existential-anxiety) - [Travel](https://www.medicalnewstoday.com/articles/travel-anxiety) - [Social](https://www.medicalnewstoday.com/articles/176891) - [Trait vs. State Anxiety](https://www.medicalnewstoday.com/articles/trait-anxiety) - [Situational](https://www.medicalnewstoday.com/articles/situational-anxiety) - [Political](https://www.medicalnewstoday.com/articles/political-anxiety) - [Hospital](https://www.medicalnewstoday.com/articles/hospital-anxiety) - [Types of Social Anxiety](https://www.medicalnewstoday.com/articles/types-of-social-anxiety) - [Eco-Anxiety](https://www.medicalnewstoday.com/articles/327354) - [Pathological](https://www.medicalnewstoday.com/articles/pathological-anxiety-definition-causes-and-symptoms) - [Free-Floating](https://www.medicalnewstoday.com/articles/free-floating-anxiety) - [Anxiety Disorders](https://www.medicalnewstoday.com/articles/types-of-anxiety) - [Anxiety in Children](https://www.medicalnewstoday.com/articles/anxiety-in-children) - [High Functioning](https://www.medicalnewstoday.com/articles/high-functioning-anxiety) - [Health](https://www.medicalnewstoday.com/articles/health-anxiety) - [Before Period](https://www.medicalnewstoday.com/articles/anxiety-before-period) - [Dating](https://www.medicalnewstoday.com/articles/dating-anxiety) - [School](https://www.medicalnewstoday.com/articles/school-anxiety) - [Friendship](https://www.medicalnewstoday.com/articles/friendship-anxiety) - [Surgery](https://www.medicalnewstoday.com/articles/surgery-anxiety) - [At Night](https://www.medicalnewstoday.com/articles/anxiety-at-night) - [Dental](https://www.medicalnewstoday.com/articles/what-to-know-about-dental-anxiety) - [In Males](https://www.medicalnewstoday.com/articles/anxiety-in-men-fighting-stereotypes) - [Hangover](https://www.medicalnewstoday.com/articles/hangover-anxiety) - [Test](https://www.medicalnewstoday.com/articles/test-anxiety-tips) - [Gym](https://www.medicalnewstoday.com/articles/gym-anxiety) - ### Complications Complications #### Related Articles - [Left Arm Pain](https://www.medicalnewstoday.com/articles/left-arm-pain-from-anxiety) - [Hot Flashes](https://www.medicalnewstoday.com/articles/anxiety-hot-flashes) - [Acid Reflux](https://www.medicalnewstoday.com/articles/acid-reflux-and-anxiety) - [Anxiety Poop](https://www.medicalnewstoday.com/articles/anxiety-poop) - [Atrial Fibrillation](https://www.medicalnewstoday.com/articles/can-anxiety-cause-atrial-fibrillation) - [Inflammation](https://www.medicalnewstoday.com/articles/anxiety-and-inflammation-is-there-a-link) - [Anxiety Dreams](https://www.medicalnewstoday.com/articles/anxiety-dreams) - ### Related Conditions Related Conditions #### Related Articles - [Vs. Depression](https://www.medicalnewstoday.com/articles/anxiety-vs-depression) - [Psychosis](https://www.medicalnewstoday.com/articles/anxiety-psychosis) - [Vs. Stress](https://www.medicalnewstoday.com/articles/stress-vs-anxiety) - [Tinnitus](https://www.medicalnewstoday.com/articles/ringing-in-ears-anxiety) - [Panic vs. Heart Attack](https://www.medicalnewstoday.com/articles/322797) - [AVPD vs. Social Anxiety](https://www.medicalnewstoday.com/articles/avpd-vs-social-anxiety) - [Vs. Paranoia](https://www.medicalnewstoday.com/articles/paranoia-vs-anxiety) - [Adjustment Disorder](https://www.medicalnewstoday.com/articles/adjustment-disorder-with-anxiety) # How to choose the best medication for anxiety alongside depression ![](https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2021/04/Nicole_Washington_500x500_Med_Reviewer_Photos_v2.png?w=105&h=105) [Medically reviewed]() by [Nicole Washington, DO, MPH]() — Written by [Karen Veazey]() on August 30, 2022 - [Prevalence](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#prevalence) - [Medications for both](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#medications-for-both) - [Combining medications safely](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#combining-medications-safely) - [Diagnosing anxiety](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#diagnosing-anxiety) - [Diagnosing depression](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#diagnosing-depression) - [Management tips](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#management-tips) - [Summary](https://www.medicalnewstoday.com/articles/what-is-the-best-medication-for-anxiety-and-depression#summary) Anxiety and depression are two common mental health diagnoses. For some, they occur as comorbidities, meaning they occur at the same time. Many medications treat both conditions, though dosages may differ. It is [normal](https://www.nimh.nih.gov/health/topics/anxiety-disorders) to experience [anxiety](https://www.medicalnewstoday.com/articles/323454) every once in a while. Symptoms can include mental distress as well as physical sensations of discomfort. Anxiety disorders develop when anxiety does not lessen as expected, and symptoms may interfere with a person’s daily life. There are multiple types of anxiety disorders. [Depression](https://www.medicalnewstoday.com/articles/8933) occurs when an individual experiences symptoms of low mood and changes in motivation, sleeping, eating, working, and habits for at least [2 weeks](https://www.nimh.nih.gov/health/topics/depression). The individual may feel sad, hopeless, despairing, and possibly irritable, among other symptoms. There are several types of depression. This article will explore how often anxiety and depression occur together, which medications treat both conditions, management tips, and more. ## [Prevalence of depression and anxiety]() ![glass vials containing medication for depression and anxiety together](https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2022/07/medication_depression_GettyImages1277352642_Header-1024x575.jpg?w=1155&h=1528) [Share on Pinterest](https://www.pinterest.com/pin/create/button/?url=https%3A%2F%2Fwww.medicalnewstoday.com%2Farticles%2Fwhat-is-the-best-medication-for-anxiety-and-depression&media=https%3A%2F%2Fpost.medicalnewstoday.com%2Fwp-content%2Fuploads%2Fsites%2F3%2F2022%2F07%2Fmedication_depression_GettyImages1277352642_Header-1024x575.jpg&description=Anxiety%20and%20depression%20together%3A%20How%20to%20choose%20the%20best%20medication "Share on Pinterest") Bloomberg Creative/Getty Images A 2015 study published in the World Journal of Psychiatry states that [generalized anxiety disorder (GAD)](https://www.medicalnewstoday.com/articles/326416) is the [most common](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694550/) anxiety disorder. [Major depressive disorder (MDD)](https://www.medicalnewstoday.com/articles/major-depressive-disorder-vs-persistent-depressive-disorder) is the most common depressive disorder. The study suggests that among people with these conditions, 62% of those with GAD may also experience MDD in their lifetime, and 59% of people with GAD had experienced an episode of MDD within the prior year. There are two schools of thought about why these conditions often appear together. One theory is that similar biological functions activate anxiety and depression. This may mean that if the [chemistry in the brain](https://www.medicalnewstoday.com/articles/326475) is in a condition that allows one condition to develop, it may also allow for the other. Another theory is that anxiety and depression share many of the same symptoms, so it is easy for a person to meet the diagnostic criteria for both conditions. [Learn more about the connection between anxiety, depression, and PTSD.](https://www.medicalnewstoday.com/articles/326903) ## [Medications for anxiety and depression]() Several types of medication treat both anxiety and depression. These include: ### Selective serotonin reuptake inhibitors [Selective serotonin reuptake inhibitors (SSRIs)](https://www.medicalnewstoday.com/articles/ssri-vs-snri) are the drug that doctors [most commonly](https://www.ncbi.nlm.nih.gov/books/NBK554406/) prescribe to treat depression and anxiety disorders. They work by increasing the amount of [serotonin](https://www.medicalnewstoday.com/articles/232248), a neurotransmitter or chemical messenger, that circulates in the brain. SSRIs that doctors prescribe in the US include: - [fluoxetine (Prozac)](https://www.medicalnewstoday.com/articles/322413) - [sertraline (Zoloft)](https://www.medicalnewstoday.com/articles/325632) - [paroxetine (Paxil)](https://www.medicalnewstoday.com/articles/325996) - fluvoxamine (Luvox) - [citalopram (Celexa)](https://www.medicalnewstoday.com/articles/celexa) - [escitalopram (Lexapro)](https://www.medicalnewstoday.com/articles/escitalopram-oral-tablet) Depending on the type of medication, most SSRIs are available in tablet or capsule form. Some may also be available as a liquid. SSRIs can have a variety of [side effects](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/side-effects/), including: - feeling agitated or nervous - gastrointestinal issues - [loss of appetite](https://www.medicalnewstoday.com/articles/324011) - weight changes - [dizziness](https://www.medicalnewstoday.com/articles/319026) - [blurred vision](https://www.medicalnewstoday.com/articles/sudden-blurry-vision) - [dry mouth](https://www.medicalnewstoday.com/articles/187640) - [sweating](https://www.medicalnewstoday.com/articles/182130) - [trouble sleeping](https://www.medicalnewstoday.com/articles/327339) - [headaches](https://www.medicalnewstoday.com/articles/73936) - [sexual dysfunction](https://www.medicalnewstoday.com/articles/315984) More serious side effects may include: - bleeding or [bruising easily](https://www.medicalnewstoday.com/articles/325525) - [vomiting blood](https://www.medicalnewstoday.com/articles/314031), which may look like coffee grounds - [blood in the stool](https://www.medicalnewstoday.com/articles/blood-in-stool) - [confusion](https://www.medicalnewstoday.com/articles/confusion) - movement problems - [hallucinations](https://www.medicalnewstoday.com/articles/327014) - problems urinating If any of these serious side effects occur, a person should notify a doctor immediately. ### Serotonin-norepinephrine reuptake inhibitors Examples of [serotonin-norepinephrine reuptake inhibitors (SNRIs)](https://www.medicalnewstoday.com/articles/snri) include [venlafaxine (Effexor XR)](https://www.medicalnewstoday.com/articles/326678) and [duloxetine (Cymbalta)](https://www.medicalnewstoday.com/articles/cymbalta). These drugs [are similar](https://adaa.org/find-help/treatment-help/medication-options) to SSRIs, but SNRIs prevent both serotonin and norepinephrine from being reabsorbed by nerve cells. They typically come in tablet form. Side effects of SNRIs may include: - gastrointestinal issues - [insomnia](https://www.medicalnewstoday.com/articles/9155) - headache - sexual dysfunction - weight gain - a minor [blood pressure](http://www.medicalnewstoday.com/articles/270644) increase ## [Medications people can safely combine]() Sometimes, combining one or more medications to treat anxiety and depression is best. A doctor may prescribe the following medications in addition to an SSRI or SNRI or use them on their own. ### Benzodiazepines SSRIs and SNRIs typically take [2–4 weeks](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694550/) to reach full effect. For this reason, a doctor may prescribe a fast-acting benzodiazepine medication for individuals with severe anxiety or [panic attacks](https://www.medicalnewstoday.com/articles/8872). Benzodiazepine medications are [habit-forming](https://adaa.org/find-help/treatment-help/medication-options) medications, and people should carefully follow their doctor’s advice in taking them. A doctor will generally prescribe them at the lowest possible dosage and only as necessary. Benzodiazepines [work](https://adf.org.au/drug-facts/benzodiazepines/) by slowing the transmission of nerve impulses between the brain and the body. Examples include: - [alprazolam (Xanax)](https://www.medicalnewstoday.com/articles/326488) - [clonazepam (Klonopin)](https://www.medicalnewstoday.com/articles/clonazepam-oral-tablet) - [diazepam (Valium)](https://www.medicalnewstoday.com/articles/diazepam-oral-tablet) - [lorazepam (Ativan)](https://www.medicalnewstoday.com/articles/326015) Benzodiazepines can have serious side effects, which may include: - depression - confusion - euphoria - impaired thinking - memory loss - headache - sleepiness - slurred speech - blurred vision - impaired coordination - [nausea](https://www.medicalnewstoday.com/articles/what-causes-nausea) - gastrointestinal issues Regular use of these medications can lead to dependence and side effects such as: - increased anxiety - personality changes - [weakness](https://www.medicalnewstoday.com/articles/asthenia-weakness) and [lethargy](https://www.medicalnewstoday.com/articles/lethargy) - drowsiness, sleepiness, and [fatigue](https://www.medicalnewstoday.com/articles/248002) - nightmares - headaches - [rash](https://www.medicalnewstoday.com/articles/317999) - weight gain - [addiction](https://www.medicalnewstoday.com/articles/323465) ### Buspirone [Buspirone](https://www.medicalnewstoday.com/articles/drugs-buspirone-oral-tablet) is an anti-anxiety medication doctors use to treat GAD, commonly at a dosage of [15–60](https://www.ncbi.nlm.nih.gov/books/NBK531477/) milligrams. It comes in tablet form, and people usually take it twice daily. This medication is an [anxiolytic](https://www.medicalnewstoday.com/articles/324015#what-is-kava-kava) and acts on the levels of serotonin and other neurotransmitters in the brain. Anxiolytic is another name for a substance that reduces anxiety levels. [Side effects](https://medlineplus.gov/druginfo/meds/a688005.html) of buspirone might include: - dizziness - gastrointestinal issues - nervousness - confusion - fatigue - trouble sleeping - anger or hostility - headache - weakness - [numbness](https://www.medicalnewstoday.com/articles/326062) - sweating More serious side effects may also occur, such as: - rash - [hives](https://www.medicalnewstoday.com/articles/157260) - itching - swelling of the face, eyes, mouth, throat, tongue, or lips - [irregular heartbeat](https://www.medicalnewstoday.com/articles/8887) - blurry vision - uncontrollable shaking - agitation - [fever](https://www.medicalnewstoday.com/articles/168266) - sweating and flushing - confusion - [shivering](https://www.medicalnewstoday.com/articles/322515) - [seizures](https://www.medicalnewstoday.com/articles/seizure) - hallucinations - loss of coordination A person should call a doctor immediately if they experience any of these effects. ### Tricyclic antidepressants An older class of antidepressants, tricyclic antidepressants, are still available for use when SSRIs and SNRIs have failed to work. They [are effective](https://adaa.org/find-help/treatment-help/medication-options) in treating anxiety disorders but can have significant side effects. [Examples](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/overview/) of tricyclic antidepressants include: - [amitriptyline (Elavil)](https://www.medicalnewstoday.com/articles/amitriptyline-oral-tablet) - amoxapine (Asendin) - trimipramine (Surmontil) - imipramine (Tofranil) - doxepin (Sinequan) - nortriptyline (Pamelor) [Side effects](https://www.fda.gov/consumers/free-publications-women/depression-medicines#Tricyclic-Tetracyclic) of tricyclic antidepressants include: - dry mouth - [constipation](https://www.medicalnewstoday.com/articles/150322) - blurred vision - drowsiness - [low blood pressure](https://www.medicalnewstoday.com/articles/159609) - urinary problems - confusion - [fainting](https://www.medicalnewstoday.com/articles/182524) - seizures - irregular heartbeat ## [Diagnostic criteria for anxiety]() For a diagnosis of GAD, there are a [few things](https://www.ncbi.nlm.nih.gov/books/NBK519704/table/ch3.t15/) the doctor will look for. According to the [Diagnostic and Statistical Manual of Mental Disorders, 5th edition, text revision (DSM-5-TR)](https://cks.nice.org.uk/topics/generalized-anxiety-disorder/diagnosis/diagnosis/), the individual should find it difficult to control their worry, and the anxiety should associate with at least three of the following symptoms on more days than not for the previous 6 months: - restlessness or feeling “keyed up” - fatigue - difficulty concentrating - [irritability](https://www.medicalnewstoday.com/articles/325564) - [muscle tension](https://www.medicalnewstoday.com/articles/rigid-muscles) - trouble sleeping The diagnostic criteria state that the person’s symptoms should cause clinically significant distress or impair important functioning, and substance misuse or another medical or mental health condition should not explain them better. ## [Diagnostic criteria for depression]() To [diagnose depression](https://www.ncbi.nlm.nih.gov/books/NBK519712/table/ch3.t5/), a doctor will look for the following: - depressed mood - [diminished interest or pleasure](https://www.medicalnewstoday.com/articles/320737) in most or all activities - significant weight loss or weight gain - increased or decreased appetite - insomnia or hypersomnia, which is when a person sleeps too much - psychomotor impairment - fatigue or loss of energy - feelings of worthlessness or excessive guilt - a diminished ability to think or concentrate - indecisiveness - recurrent thoughts of death or [suicidal ideation](https://www.medicalnewstoday.com/articles/193026), with or without planning or an attempt Current diagnostic criteria state that a person’s symptoms must cause clinically significant distress in a way that interferes with daily functioning. For a doctor to diagnose a major depressive episode, five or more symptoms should be present most of the day for at least 2 weeks in a row. Symptoms must not be due to substance misuse or a medical condition. They should also not be attributable to a condition on the [schizophrenia](https://www.medicalnewstoday.com/articles/36942) spectrum, another psychotic disorder, or bereavement. ## [Other tips and treatments]() There are ways a person can try to [manage anxiety and depression](https://adaa.org/tips) at home, such as by: - limiting [alcohol](https://www.medicalnewstoday.com/articles/305062) and [caffeine](https://www.medicalnewstoday.com/articles/285194) - getting enough [sleep](https://www.medicalnewstoday.com/articles/sleep-and-mental-health) - [exercising](https://www.medicalnewstoday.com/articles/322734) daily - [meditating](https://www.medicalnewstoday.com/articles/320392) - seeking out humor - eating [balanced meals](https://www.medicalnewstoday.com/articles/324093) - planning time out to do [yoga](https://www.medicalnewstoday.com/articles/286745), get a [massage](https://www.medicalnewstoday.com/articles/317675), or practice [deep breathing techniques](https://www.medicalnewstoday.com/articles/breathing-techniques) to clear the mind - volunteering - learning about anxiety and depression - talking with a trusted person about thoughts and feelings »MORE:[Get a refill for your medication in as little as 15 minutes with Optum Now Online Care.](https://now.optum.com/online-care/prescription-refill?utm_source=mnt&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-rxrefill&utm_campaign=mnt-article-oc-on-backlink%20%20%20%20) Optum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.medicalnewstoday.com/about/brand-and-product-vetting) ## [Summary]() Dealing with anxiety and depression can be daunting, but several medications and combinations of medications provide effective treatment. For most people, newer SSRIs and SNRIs have fewer side effects while providing clinical results. For some, these medications may not provide relief, and older tricyclic antidepressants may be a better option. Early in treatment, a doctor may also recommend a benzodiazepine if anxiety is a particular challenge. However, these medications are habit-forming and should not be a long-term choice. Instead, they create a bridge while SSRIs and SNRIs take effect. - [Depression](https://www.medicalnewstoday.com/categories/depression) - [Anxiety / Stress](https://www.medicalnewstoday.com/categories/anxiety) - [Drugs](https://www.medicalnewstoday.com/categories/drugs) ### How we reviewed this article: Sources Medical News Today has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.medicalnewstoday.com/articles/process). - Anxiety disorders. (2022). <https://www.nimh.nih.gov/health/topics/anxiety-disorders> - Benzodiazepines. (2022). <https://adf.org.au/drug-facts/benzodiazepines/> - Buspirone. (2019). <https://medlineplus.gov/druginfo/meds/a688005.html> - Chapter 3.3.1. Major depressive episode/disorder. DSM-5 Changes: Implications for Child Serious Emotional Disturbance. (2016). <https://www.ncbi.nlm.nih.gov/books/NBK519712> - Chapter 3.3.9. Generalized anxiety disorder (MHSS). Impact of the DSM-IV to DSM-5 Changes on the National Survey on Drug Use and Health. (2016). <https://www.ncbi.nlm.nih.gov/books/NBK519704> - Chu, A., et. al., (2022). Selective serotonin reuptake inhibitors. <https://www.ncbi.nlm.nih.gov/books/NBK554406/> - Coplan, J. D., et. al. (2015). Treating comorbid anxiety and depression: Psychosocial and pharmacological approaches. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694550/> - Depression. (2022). <https://www.nimh.nih.gov/health/topics/depression> - Depression medicines. (2019). <https://www.fda.gov/consumers/free-publications-women/depression-medicines#Tricyclic-Tetracyclic> - Ellen, S., et. al. (2017). Depression and anxiety: Pharmacological treatment in general practice. <https://www.racgp.org.au/getattachment/87865c41-fdd7-4eb1-8920-cb0c7f02d8a9/attachment.aspx> - Medication options. (2019). <https://adaa.org/find-help/treatment-help/medication-options> - Side effects: Selective serotonin reuptake inhibitors (SSRIs). (2021). <https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/side-effects/> - Tips and strategies to manage anxiety and stress. (2022). <https://adaa.org/tips> - When should I suspect generalized anxiety disorder? (2022). <https://cks.nice.org.uk/topics/generalized-anxiety-disorder/diagnosis/diagnosis/> - Wilson, T. K., et. al. (2022). Buspirone. <https://www.ncbi.nlm.nih.gov/books/NBK531477/> Share this article ![](https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2021/04/Nicole_Washington_500x500_Med_Reviewer_Photos_v2.png?w=105&h=105) [Medically reviewed]() by [Nicole Washington, DO, MPH]() — Written by [Karen Veazey]() on August 30, 2022 ## Latest news - [US vaccine guideline changes challenge clinical practice, insurance coverage](https://www.medicalnewstoday.com/articles/us-vaccine-changes-challenge-clinical-practice-insurance-coverage) - [Exercise prevents muscle loss as we age: Here's how](https://www.medicalnewstoday.com/articles/exercise-prevents-muscle-loss-aging-how-protein-biology) - [Moving just 5 more minutes each day could boost longevity](https://www.medicalnewstoday.com/articles/moving-just-5-more-minutes-each-day-could-boost-longevity) - [New Mount Sinai AI tool aims to improve access to cancer clinical trials](https://www.medicalnewstoday.com/articles/mount-sinai-ai-tool-aims-to-improve-access-to-cancer-clinical-trials) - [Early menopause not linked to higher diabetes risk, study finds](https://www.medicalnewstoday.com/articles/early-menopause-not-linked-higher-type-2-diabetes-risk) ### Related Coverage - [What are the best medications to treat generalized anxiety disorder?](https://www.medicalnewstoday.com/articles/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext) [Doctors may prescribe medications such as antidepressants to treat generalized anxiety disorder. Learn more here.](https://www.medicalnewstoday.com/articles/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext) [READ MORE](https://www.medicalnewstoday.com/articles/best-medication-for-generalized-anxiety-disorder?utm_source=ReadNext) - [How to safely medicate for anxiety alongside heart issues](https://www.medicalnewstoday.com/articles/best-anxiety-medication-for-heart-patients?utm_source=ReadNext) Medically reviewed by [Nicole Washington, DO, MPH](https://www.medicalnewstoday.com/reviewers) [Anxiety and heart conditions may occur together. 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