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| Meta Title | Pros and Cons of antidepressants |
| Meta Description | There are various pros and cons of taking antidepressants. Understanding these can help an individual decided whether antidepressants are right for them. Learn more here. |
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| Boilerpipe Text | Understanding the pros and cons of antidepressants can help an individual decide if they are the right treatment for them.
Antidepressant medications can help relieve the symptoms of depression, anxiety, and other conditions. Many people benefit from antidepressants. However, they may not work for everyone. They may also cause side effects, although these are typically mild.
Around 13%
of adults in the United States take antidepressants. Prescriptions of these medications have continued to increase in recent years.
Antidepressants
can help
reduce symptoms of depression. These may include feelings of hopelessness, tiredness, or sleep disturbances. However, antidepressants
may also cause
side effects like appetite loss, headaches, or weight gain.
This article will explore the pros and cons of antidepressants. Keep reading to learn about what they do, potential side effects, and more.
The effectiveness of antidepressants depends on a number of factors. Some individuals may benefit from certain types of antidepressants more than others. They are
typically most effective
for individuals with severe, long-term
depression
.
Antidepressants may also take some time to produce an effect. In some cases, antidepressants may begin to work within a couple of weeks. However, it may take longer in other cases.
Researchers have demonstrated the effectiveness of antidepressants over placebo. One review found that antidepressants were more effective than placebo in
over 500
different trials.
Overall, how effective an antidepressant is depends on the individual. Some people may also benefit from taking a combination of different antidepressants at the same time. To learn more about the effectiveness of antidepressants, speak with a healthcare professional.
Antidepressants can help reduce the
symptoms of depression
. They can also help prevent a relapse.
Improved quality of life and motivation
The symptoms of depression can have a negative effect on quality of life. Antidepressants can help address these symptoms to improve overall quality of life.
One study looked at people with anxiety, depression, or a combination of the two. After 36 weeks,
over 90%
of these individuals reported improved sleep. They also reported improvements in their quality of life and overall pleasure.
Improving life satisfaction can increase feelings of motivation. Boosting sleep quality can also make day-to-day tasks easier.
Symptom relief
Antidepressants can help relieve common depression symptoms. These
may include
:
feelings of hopelessness or worthlessness
feelings of sadness
reduced energy levels
tiredness
difficulties with focus or decision-making
appetite changes
weight loss or gain
lack of interest in favorite activities
sleeping too much or too little
Relieving depression symptoms
can help
speed recovery in certain cases.
Overall safety
In most cases, antidepressants do not cause serious side effects. They may cause mild side effects for some individuals. However, these effects typically resolve on their own over time.
Antidepressants
may not be safe
for everyone. For example, healthcare professionals typically do not recommend antidepressants for pregnant individuals. This is to prevent any potential effects on a developing fetus. To learn more about antidepressant safety, consult with a healthcare professional.
Many individuals have a positive experience with taking antidepressants. However, these medications can be less effective or suitable for others.
Side effects
Some people may experience negative side effects while taking antidepressants. These side effects
may include
:
increased
anxiety
headaches
appetite changes
dizziness
stomach upset
gastrointestinal issues
sleeping too much or too little
difficulties with sexual intimacy
In rare cases, certain antidepressants can increase
thoughts of suicide
. This is particularly common among younger individuals. Anyone experiencing this or other side effects should speak with a healthcare or mental health professional. They may recommend stopping the medication or trying a different antidepressant.
Delayed onset
Antidepressants may also take some time to work. Individuals may have to take an antidepressant for
up to 8 weeks
before noticing any improvements.
Individuals with moderate or severe depression should speak with a healthcare professional to learn more. They may recommend additional treatments like
psychotherapy
. A combination of medication and psychotherapy is a
common treatment
for depression.
Stigma
Research has shown
that the stigma surrounding antidepressants persists to this day. Some people may avoid taking antidepressants because of these negative stereotypes.
Cost
The cost of antidepressants may also deter people from taking them. One study found that prescription medications in the United States cost
256% more than
in other countries.
Some insurance plans or pharmaceutical companies may provide partial or full coverage of these costs. Speak with an insurance provider or healthcare professional to learn more about payment options and discounts.
Not all antidepressants work for everyone
Each person
may respond better
to some antidepressants than others. Some people may have to try multiple antidepressants before they find the right one. Others may not see improvement even after they have tried multiple different antidepressants.
Individuals should speak with a healthcare or mental health professional about other treatment options if antidepressants are not effective.
The following are some questions people frequently ask about antidepressants.
How good do antidepressants make you feel?
Antidepressants can help relieve depression symptoms and boost overall mood and life enjoyment. Some people may experience complete recovery from their depression. Others may experience reduced symptoms as part of their recovery journey.
Do antidepressants make you gain weight?
Certain antidepressants can lead to weight gain. One
10-year study found
that the increased use of antidepressants might even be contributing to the obesity epidemic.
However, other antidepressants
may also lead to
weight loss. The effects of each antidepressant can vary between individuals. To learn more about which antidepressants affect weight, speak with a healthcare professional.
At what point is it worth trying antidepressants?
Antidepressants are
particularly helpful
for individuals with severe depression. People experiencing severe symptoms of depression may choose to try antidepressants.
What percentage of people get better on antidepressants?
The percentage of people who get better on antidepressants depends on the individual and the type of medication. Some people may make a full recovery with antidepressants. Others may require additional treatments, like therapy, to see improvement.
Antidepressants can help relieve the symptoms of depression and other mental health conditions. Most people who take these medications do not experience serious side effects.
However, antidepressants can cause uncomfortable side effects in certain cases. They may work better for some individuals than others.
There’s no single cure-all treatment for depression. Each individual may respond better to a different antidepressant. Or they may recover with a combination of medications, therapy, and other treatment options. Speak with a healthcare professional to learn more about a personalized treatment plan. |
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- [Depression at Night](https://www.medicalnewstoday.com/articles/depression-at-night)
- [Spiritual](https://www.medicalnewstoday.com/articles/spiritual-depression)
- [Breakthrough](https://www.medicalnewstoday.com/articles/breakthrough-depression)
- [Work](https://www.medicalnewstoday.com/articles/work-depression)
- [Catatonic](https://www.medicalnewstoday.com/articles/322199)
- [High-Functioning](https://www.medicalnewstoday.com/articles/high-functioning-depression)
- [Seasonal Affective Disorder](https://www.medicalnewstoday.com/articles/10306)
- [Subsyndromal](https://www.medicalnewstoday.com/articles/subsyndromal-depression)
- [Geriatric](https://www.medicalnewstoday.com/articles/geriatric-depression)
- [Unipolar](https://www.medicalnewstoday.com/articles/unipolar-depression)
- [Postpartum](https://www.medicalnewstoday.com/articles/237109)
- [Treatment-Resistant](https://www.medicalnewstoday.com/articles/treatment-resistant-depression)
- [Severe](https://www.medicalnewstoday.com/articles/severe-depression)
# What are the pros and cons of antidepressants?

[Medically reviewed]() by [Monica Kean, PharmD]() — Written by Carolyn Farnsworth on October 4, 2023
- [Effectiveness](https://www.medicalnewstoday.com/articles/pros-and-cons-of-antidepressants#effectiveness)
- [Pros](https://www.medicalnewstoday.com/articles/pros-and-cons-of-antidepressants#pros)
- [Cons](https://www.medicalnewstoday.com/articles/pros-and-cons-of-antidepressants#cons)
- [FAQ](https://www.medicalnewstoday.com/articles/pros-and-cons-of-antidepressants#faq)
- [Summary](https://www.medicalnewstoday.com/articles/pros-and-cons-of-antidepressants#summary)
Understanding the pros and cons of antidepressants can help an individual decide if they are the right treatment for them.
Antidepressant medications can help relieve the symptoms of depression, anxiety, and other conditions. Many people benefit from antidepressants. However, they may not work for everyone. They may also cause side effects, although these are typically mild.
[Around 13%](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083940/) of adults in the United States take antidepressants. Prescriptions of these medications have continued to increase in recent years.
Antidepressants [can help](https://medlineplus.gov/antidepressants.html) reduce symptoms of depression. These may include feelings of hopelessness, tiredness, or sleep disturbances. However, antidepressants [may also cause](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/side-effects/) side effects like appetite loss, headaches, or weight gain.
This article will explore the pros and cons of antidepressants. Keep reading to learn about what they do, potential side effects, and more.
## [How effective are antidepressants?]()

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The effectiveness of antidepressants depends on a number of factors. Some individuals may benefit from certain types of antidepressants more than others. They are [typically most effective](https://www.ncbi.nlm.nih.gov/books/NBK361016/) for individuals with severe, long-term [depression](https://www.medicalnewstoday.com/articles/8933).
Antidepressants may also take some time to produce an effect. In some cases, antidepressants may begin to work within a couple of weeks. However, it may take longer in other cases.
Researchers have demonstrated the effectiveness of antidepressants over placebo. One review found that antidepressants were more effective than placebo in [over 500](https://www.thelancet.com/article/S0140-6736\(17\)32802-7/fulltext) different trials.
Overall, how effective an antidepressant is depends on the individual. Some people may also benefit from taking a combination of different antidepressants at the same time. To learn more about the effectiveness of antidepressants, speak with a healthcare professional.
[Learn more about antidepressants.](https://www.medicalnewstoday.com/articles/248320)
## [Pros of antidepressants]()
Antidepressants can help reduce the [symptoms of depression](https://www.medicalnewstoday.com/articles/326769). They can also help prevent a relapse.
### Improved quality of life and motivation
The symptoms of depression can have a negative effect on quality of life. Antidepressants can help address these symptoms to improve overall quality of life.
One study looked at people with anxiety, depression, or a combination of the two. After 36 weeks, [over 90%](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511371/) of these individuals reported improved sleep. They also reported improvements in their quality of life and overall pleasure.
Improving life satisfaction can increase feelings of motivation. Boosting sleep quality can also make day-to-day tasks easier.
### Symptom relief
Antidepressants can help relieve common depression symptoms. These [may include](https://www.nimh.nih.gov/health/topics/depression):
- feelings of hopelessness or worthlessness
- feelings of sadness
- reduced energy levels
- tiredness
- difficulties with focus or decision-making
- appetite changes
- weight loss or gain
- lack of interest in favorite activities
- sleeping too much or too little
Relieving depression symptoms [can help](https://www.ncbi.nlm.nih.gov/books/NBK279282/) speed recovery in certain cases.
### Overall safety
In most cases, antidepressants do not cause serious side effects. They may cause mild side effects for some individuals. However, these effects typically resolve on their own over time.
Antidepressants [may not be safe](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/) for everyone. For example, healthcare professionals typically do not recommend antidepressants for pregnant individuals. This is to prevent any potential effects on a developing fetus. To learn more about antidepressant safety, consult with a healthcare professional.
## [Cons of antidepressants]()
Many individuals have a positive experience with taking antidepressants. However, these medications can be less effective or suitable for others.
### Side effects
Some people may experience negative side effects while taking antidepressants. These side effects [may include](https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/side-effects/):
- increased [anxiety](https://www.medicalnewstoday.com/articles/323454)
- [headaches](https://www.medicalnewstoday.com/articles/headaches)
- appetite changes
- dizziness
- stomach upset
- gastrointestinal issues
- sleeping too much or too little
- [difficulties with sexual intimacy](https://www.medicalnewstoday.com/articles/315984)
In rare cases, certain antidepressants can increase [thoughts of suicide](https://www.medicalnewstoday.com/articles/193026). This is particularly common among younger individuals. Anyone experiencing this or other side effects should speak with a healthcare or mental health professional. They may recommend stopping the medication or trying a different antidepressant.
### Help is out there
If you or someone you know is in crisis and considering suicide or self-harm, please seek support:
- Call or text the [988 Lifeline](https://988lifeline.org/) at 988 or chat at 988lifeline.org. Caring counselors are available to listen and provide free and confidential support 24/7.
- Text HOME to the [Crisis Text Line](https://www.crisistextline.org/?gclid=EAIaIQobChMIsPDQrdXH5wIVBRx9Ch1YdQjIEAAYASAAEgJ_1_D_BwE) at 741741 to connect with a volunteer crisis counselor for free and confidential support 24/7.
- Not in the United States? Find a helpline in your country with [Befrienders Worldwide](https://www.befrienders.org/).
- Call 911 or your local emergency services number if you feel safe to do so.
If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely.
If you’re not in the same household, stay on the phone with them until help arrives.
### Delayed onset
Antidepressants may also take some time to work. Individuals may have to take an antidepressant for [up to 8 weeks](https://psychcentral.com/depression/how-long-do-antidepressants-take-to-work) before noticing any improvements.
Individuals with moderate or severe depression should speak with a healthcare professional to learn more. They may recommend additional treatments like [psychotherapy](https://www.medicalnewstoday.com/articles/156433). A combination of medication and psychotherapy is a [common treatment](https://www.nimh.nih.gov/health/topics/depression) for depression.
### Stigma
[Research has shown](https://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm20239) that the stigma surrounding antidepressants persists to this day. Some people may avoid taking antidepressants because of these negative stereotypes.
### Cost
The cost of antidepressants may also deter people from taking them. One study found that prescription medications in the United States cost [256% more than](https://www.rand.org/pubs/research_reports/RR2956.html) in other countries.
Some insurance plans or pharmaceutical companies may provide partial or full coverage of these costs. Speak with an insurance provider or healthcare professional to learn more about payment options and discounts.
### Not all antidepressants work for everyone
Each person [may respond better](https://www.ncbi.nlm.nih.gov/books/NBK361016/) to some antidepressants than others. Some people may have to try multiple antidepressants before they find the right one. Others may not see improvement even after they have tried multiple different antidepressants.
Individuals should speak with a healthcare or mental health professional about other treatment options if antidepressants are not effective.
## [Frequently asked questions]()
The following are some questions people frequently ask about antidepressants.
### How good do antidepressants make you feel?
Antidepressants can help relieve depression symptoms and boost overall mood and life enjoyment. Some people may experience complete recovery from their depression. Others may experience reduced symptoms as part of their recovery journey.
### Do antidepressants make you gain weight?
Certain antidepressants can lead to weight gain. One [10-year study found](https://www.bmj.com/content/361/bmj.k1951) that the increased use of antidepressants might even be contributing to the obesity epidemic.
However, other antidepressants [may also lead to](https://pubmed.ncbi.nlm.nih.gov/33022115/) weight loss. The effects of each antidepressant can vary between individuals. To learn more about which antidepressants affect weight, speak with a healthcare professional.
### At what point is it worth trying antidepressants?
Antidepressants are [particularly helpful](https://www.ncbi.nlm.nih.gov/books/NBK361016/) for individuals with severe depression. People experiencing severe symptoms of depression may choose to try antidepressants.
### What percentage of people get better on antidepressants?
The percentage of people who get better on antidepressants depends on the individual and the type of medication. Some people may make a full recovery with antidepressants. Others may require additional treatments, like therapy, to see improvement.
## [Summary]()
Antidepressants can help relieve the symptoms of depression and other mental health conditions. Most people who take these medications do not experience serious side effects.
However, antidepressants can cause uncomfortable side effects in certain cases. They may work better for some individuals than others.
There’s no single cure-all treatment for depression. Each individual may respond better to a different antidepressant. Or they may recover with a combination of medications, therapy, and other treatment options. Speak with a healthcare professional to learn more about a personalized treatment plan.
- [Depression](https://www.medicalnewstoday.com/categories/depression)
- [Mental Health](https://www.medicalnewstoday.com/categories/mental-health)
- [Psychology / Psychiatry](https://www.medicalnewstoday.com/categories/psychology-psychiatry)
### How we reviewed this article:
Sources
Medical News Today has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.medicalnewstoday.com/articles/process).
- Antidepressants. (2022).
<https://medlineplus.gov/antidepressants.html>
- Cautions - antidepressants. (2021).
<https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/considerations/>
- Cipriani A, et al. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis.
<https://www.thelancet.com/article/S0140-6736(17)32802-7/fulltext>
- Crowe M, et al. (2023). Experience of antidepressant use and discontinuation: a qualitative synthesis of the evidence.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10083940/>
- Depression. (2023).
<https://www.nimh.nih.gov/health/topics/depression#part_2255>
- Depression: how effective are antidepressants? (2023).
<https://www.ncbi.nlm.nih.gov/books/NBK361016/>
- Dzevlan A, et al. (2019). Quality of life assessment in antidepressant treatment of patients with depression and/Or anxiety disorder.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511371/>
- Gafoor R. (2018). Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study.
<https://www.bmj.com/content/361/bmj.k1951>
- Gill H, et al. (2020). Antidepressant medications and weight change: a narrative review.
<https://pubmed.ncbi.nlm.nih.gov/33022115/>
- Mulcahy AW, et al. (2021). International prescription drug price comparisons.
<https://www.rand.org/pubs/research_reports/RR2956.html>
- Side effects - antidepressants. (2021).
<https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/antidepressants/side-effects/>
- Treatments for depression. (2020).
<https://www.ncbi.nlm.nih.gov/books/NBK279282/>
- Yan X-J, et al. (2022). Improving clinician-patient communication alleviates stigma in patients with functional dyspepsia receiving antidepressant treatment.
<https://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm20239>
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[Medically reviewed]() by [Monica Kean, PharmD]() — Written by Carolyn Farnsworth on October 4, 2023
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