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URLhttps://www.immunize.org/ask-experts/topic/hepa/international-travel/
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Meta TitleAsk The Experts About Vaccines: Hepatitis A | International Travel | Immunize.org
Meta DescriptionRead answers by medical experts to healthcare provider questions on vaccines and Hepatitis A | International Travel.
Meta Canonicalorg,immunize!www,/ask-experts/topic/hepa/international-travel/ h80
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Results (10) Hepatitis A vaccination is recommended for people age 6 months or older who are traveling to or working in an area of the world at intermediate or high risk of hepatitis A transmission. Areas of low risk include the United States, Canada, Japan, New Zealand, Australia and Western Europe. Visit the CDC’s Traveler Health website for more information about specific destinations and current outbreaks or travel notices ( https://wwwnc.cdc.gov/travel/ ). When in doubt, vaccinate. Last reviewed: June 25, 2023 For details on preexposure protection of international travelers age 12 months and older, refer to Appendix A on page 35 of the current ACIP recommendations for the prevention of hepatitis A:  www.cdc.gov/mmwr/volumes/69/rr/pdfs/rr6905a1-H.pdf . Healthy people age 12 months through 40 years who are planning travel to an area with high or intermediate HAV endemicity and have not received HepA vaccine should receive a single dose of HepA vaccine as soon as travel is considered and should complete the 2-does series according to the routine schedule. People with chronic liver disease as well as adults older than 40 years of age, immunocompromised people, and people with other chronic medical conditions planning to depart to an area with high or intermediate HAV endemicity in less than 2 weeks should receive the initial dose of HepA vaccine and may also simultaneously be administered immune globulin (IG) at a separate anatomic injection site (for example in separate limbs). ACIP revised its recommendations for preexposure hepatitis A vaccination for travelers in 2018 to include vaccination of infants 6 through 11 months of age. All infants of this age traveling internationally should be given a dose of measles, mumps, rubella vaccine (MMR) before travel. Due to the potential interference of hepatitis A IG with MMR vaccine effectiveness, an off-label dose of HepA vaccine is recommended instead of IG in this situation. The travel-related dose for infants 6–11 months of age should not be counted toward the routine 2-dose series. The routine 2-dose HepA and MMR vaccination series should be initiated at age 12 months according to the routine, age-appropriate vaccination schedule. Infants younger than 6 months and travelers who elect not to receive vaccine or for whom vaccine is contraindicated should receive a single 0.1 mL/kg dose of IG before travel when protection against HAV is recommended. If travel is for more than 1 month, a dose of 0.2 mL/kg should be administered. A 0.2 mL/kg dose can be repeated every 2 months for travel of more than 2 months duration. Last reviewed: June 25, 2023 Yes. If time allows, use the standard Twinrix schedule of 3 doses given intramuscularly on a 0-, 1-, and 6-month schedule. If travel is imminent the accelerated 4-dose Twinrix schedule can be used: 3 doses given on days 0, 7, and 21-30 days and a booster dose at 12 months. Last reviewed: January 27, 2025 No. There is no recommendation for a booster dose of HepA if a patient has completed the 2-dose series at any age. Last reviewed: June 25, 2023 Yes. Data have shown that people acquire hepatitis A virus infection even in such places as 4-star hotels located in Latin America. Last reviewed: June 25, 2023 No. Just give the final dose of HepA vaccine prior to travel. Last reviewed: June 25, 2023 Possibly. Since IG protects against hepatitis A infection for only 1 to 2 months, depending on the dosage given, additional IG may be needed if the infant is not yet age 6 months. Once the child has reached six months of age, HepA vaccine should be given. Last reviewed: June 25, 2023 Yes. ACIP recommends that all children age 1 year through 18 years should be vaccinated against hepatitis A. VFC HepA vaccine may be administered to any eligible child, including those recommended for vaccination at 6 through 11 months of age as a result of travel to an HAV-endemic area. Last reviewed: June 25, 2023 It depends on whether that person has a history of HAV infection. Unless there are medical records that document prior HAV infection, serologic testing for immunity (positive test for total anti-HAV) is the only way to determine if vaccination is necessary. For people from countries with high rates of HAV infection, such as Vietnam and Mexico, serologic testing might be done to prevent unnecessary vaccination. The cost effectiveness of serologic testing, however, should be balanced against the possibility of delaying needed vaccination while awaiting test results. Last reviewed: June 25, 2023 No, as long as there are medical records that document that the person was previously infected with HAV (i.e., positive test for total anti-HAV). If there is any doubt that the person actually was infected with HAV, HepA vaccine and/or IG should be given. The vaccine or IG will not harm a person who is already immune. Last reviewed: June 25, 2023 This page was updated on January 27, 2025 .
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Hepatitis A vaccination is recommended for people age 6 months or older who are traveling to or working in an area of the world at intermediate or high risk of hepatitis A transmission. Areas of low risk include the United States, Canada, Japan, New Zealand, Australia and Western Europe. Visit the CDC’s Traveler Health website for more information about specific destinations and current outbreaks or travel notices (<https://wwwnc.cdc.gov/travel/>). When in doubt, vaccinate. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## What are the recommendations for vaccination of travelers to protect them from hepatitis A virus (HAV) infection? For details on preexposure protection of international travelers age 12 months and older, refer to Appendix A on page 35 of the current ACIP recommendations for the prevention of hepatitis A: [www.cdc.gov/mmwr/volumes/69/rr/pdfs/rr6905a1-H.pdf](http://www.cdc.gov/mmwr/volumes/69/rr/pdfs/rr6905a1-H.pdf). Healthy people age 12 months through 40 years who are planning travel to an area with high or intermediate HAV endemicity and have not received HepA vaccine should receive a single dose of HepA vaccine as soon as travel is considered and should complete the 2-does series according to the routine schedule. People with chronic liver disease as well as adults older than 40 years of age, immunocompromised people, and people with other chronic medical conditions planning to depart to an area with high or intermediate HAV endemicity in less than 2 weeks should receive the initial dose of HepA vaccine and may also simultaneously be administered immune globulin (IG) at a separate anatomic injection site (for example in separate limbs). ACIP revised its recommendations for preexposure hepatitis A vaccination for travelers in 2018 to include vaccination of infants 6 through 11 months of age. All infants of this age traveling internationally should be given a dose of measles, mumps, rubella vaccine (MMR) before travel. Due to the potential interference of hepatitis A IG with MMR vaccine effectiveness, an off-label dose of HepA vaccine is recommended instead of IG in this situation. The travel-related dose for infants 6–11 months of age should not be counted toward the routine 2-dose series. The routine 2-dose HepA and MMR vaccination series should be initiated at age 12 months according to the routine, age-appropriate vaccination schedule. Infants younger than 6 months and travelers who elect not to receive vaccine or for whom vaccine is contraindicated should receive a single 0.1 mL/kg dose of IG before travel when protection against HAV is recommended. If travel is for more than 1 month, a dose of 0.2 mL/kg should be administered. A 0.2 mL/kg dose can be repeated every 2 months for travel of more than 2 months duration. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## Can Twinrix (HepA-HepB combination vaccine) be used for people planning international travel? Yes. If time allows, use the standard Twinrix schedule of 3 doses given intramuscularly on a 0-, 1-, and 6-month schedule. If travel is imminent the accelerated 4-dose Twinrix schedule can be used: 3 doses given on days 0, 7, and 21-30 days and a booster dose at 12 months. Last reviewed: January 27, 2025 Link copied - Hepatitis A - International Travel ## We have an adult patient who received the correct pediatric series of HepA vaccine as a teenager and is now traveling abroad. Does the patient need an adult booster? No. There is no recommendation for a booster dose of HepA if a patient has completed the 2-dose series at any age. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## Is it really necessary to vaccinate travelers to Latin America who will be staying in 4-star hotels against hepatitis A? Yes. Data have shown that people acquire hepatitis A virus infection even in such places as 4-star hotels located in Latin America. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## If a traveler received the first dose of HepA vaccine more than one year ago and needs to travel abroad imminently, will the traveler need immune globulin in addition to dose \#2 prior to leaving? No. Just give the final dose of HepA vaccine prior to travel. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## If an infant younger than age 6 months receives immune globulin (IG) before travel to a hepatitis A endemic area, will he/she need HepA vaccine before another trip to a hepatitis A endemic area? Possibly. Since IG protects against hepatitis A infection for only 1 to 2 months, depending on the dosage given, additional IG may be needed if the infant is not yet age 6 months. Once the child has reached six months of age, HepA vaccine should be given. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## Can VFC-eligible children who travel to regions where hepatitis A virus (HAV) is endemic receive HepA vaccine under the VFC program? Yes. ACIP recommends that all children age 1 year through 18 years should be vaccinated against hepatitis A. VFC HepA vaccine may be administered to any eligible child, including those recommended for vaccination at 6 through 11 months of age as a result of travel to an HAV-endemic area. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## If a person was born and grew up in a country where HAV infection is endemic (e.g., Vietnam, Mexico) and then moved to the United States at age 20, should that person receive HepA vaccine before returning to visit his/her homeland? It depends on whether that person has a history of HAV infection. Unless there are medical records that document prior HAV infection, serologic testing for immunity (positive test for total anti-HAV) is the only way to determine if vaccination is necessary. For people from countries with high rates of HAV infection, such as Vietnam and Mexico, serologic testing might be done to prevent unnecessary vaccination. The cost effectiveness of serologic testing, however, should be balanced against the possibility of delaying needed vaccination while awaiting test results. Last reviewed: June 25, 2023 Link copied - Hepatitis A - International Travel ## If a person has had HAV infection, should they still receive the vaccine if planning international travel? No, as long as there are medical records that document that the person was previously infected with HAV (i.e., positive test for total anti-HAV). If there is any doubt that the person actually was infected with HAV, HepA vaccine and/or IG should be given. The vaccine or IG will not harm a person who is already immune. 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Results (10) Hepatitis A vaccination is recommended for people age 6 months or older who are traveling to or working in an area of the world at intermediate or high risk of hepatitis A transmission. Areas of low risk include the United States, Canada, Japan, New Zealand, Australia and Western Europe. Visit the CDC’s Traveler Health website for more information about specific destinations and current outbreaks or travel notices (<https://wwwnc.cdc.gov/travel/>). When in doubt, vaccinate. Last reviewed: June 25, 2023 For details on preexposure protection of international travelers age 12 months and older, refer to Appendix A on page 35 of the current ACIP recommendations for the prevention of hepatitis A: [www.cdc.gov/mmwr/volumes/69/rr/pdfs/rr6905a1-H.pdf](http://www.cdc.gov/mmwr/volumes/69/rr/pdfs/rr6905a1-H.pdf). Healthy people age 12 months through 40 years who are planning travel to an area with high or intermediate HAV endemicity and have not received HepA vaccine should receive a single dose of HepA vaccine as soon as travel is considered and should complete the 2-does series according to the routine schedule. People with chronic liver disease as well as adults older than 40 years of age, immunocompromised people, and people with other chronic medical conditions planning to depart to an area with high or intermediate HAV endemicity in less than 2 weeks should receive the initial dose of HepA vaccine and may also simultaneously be administered immune globulin (IG) at a separate anatomic injection site (for example in separate limbs). ACIP revised its recommendations for preexposure hepatitis A vaccination for travelers in 2018 to include vaccination of infants 6 through 11 months of age. All infants of this age traveling internationally should be given a dose of measles, mumps, rubella vaccine (MMR) before travel. Due to the potential interference of hepatitis A IG with MMR vaccine effectiveness, an off-label dose of HepA vaccine is recommended instead of IG in this situation. The travel-related dose for infants 6–11 months of age should not be counted toward the routine 2-dose series. The routine 2-dose HepA and MMR vaccination series should be initiated at age 12 months according to the routine, age-appropriate vaccination schedule. Infants younger than 6 months and travelers who elect not to receive vaccine or for whom vaccine is contraindicated should receive a single 0.1 mL/kg dose of IG before travel when protection against HAV is recommended. If travel is for more than 1 month, a dose of 0.2 mL/kg should be administered. A 0.2 mL/kg dose can be repeated every 2 months for travel of more than 2 months duration. Last reviewed: June 25, 2023 Yes. If time allows, use the standard Twinrix schedule of 3 doses given intramuscularly on a 0-, 1-, and 6-month schedule. If travel is imminent the accelerated 4-dose Twinrix schedule can be used: 3 doses given on days 0, 7, and 21-30 days and a booster dose at 12 months. Last reviewed: January 27, 2025 No. There is no recommendation for a booster dose of HepA if a patient has completed the 2-dose series at any age. Last reviewed: June 25, 2023 Yes. Data have shown that people acquire hepatitis A virus infection even in such places as 4-star hotels located in Latin America. Last reviewed: June 25, 2023 No. Just give the final dose of HepA vaccine prior to travel. Last reviewed: June 25, 2023 Possibly. Since IG protects against hepatitis A infection for only 1 to 2 months, depending on the dosage given, additional IG may be needed if the infant is not yet age 6 months. Once the child has reached six months of age, HepA vaccine should be given. Last reviewed: June 25, 2023 Yes. ACIP recommends that all children age 1 year through 18 years should be vaccinated against hepatitis A. VFC HepA vaccine may be administered to any eligible child, including those recommended for vaccination at 6 through 11 months of age as a result of travel to an HAV-endemic area. Last reviewed: June 25, 2023 It depends on whether that person has a history of HAV infection. Unless there are medical records that document prior HAV infection, serologic testing for immunity (positive test for total anti-HAV) is the only way to determine if vaccination is necessary. For people from countries with high rates of HAV infection, such as Vietnam and Mexico, serologic testing might be done to prevent unnecessary vaccination. The cost effectiveness of serologic testing, however, should be balanced against the possibility of delaying needed vaccination while awaiting test results. Last reviewed: June 25, 2023 No, as long as there are medical records that document that the person was previously infected with HAV (i.e., positive test for total anti-HAV). If there is any doubt that the person actually was infected with HAV, HepA vaccine and/or IG should be given. The vaccine or IG will not harm a person who is already immune. Last reviewed: June 25, 2023 This page was updated on January 27, 2025 .
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