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URLhttps://www.hopkinsmedicine.org/health/conditions-and-diseases/dermatitis-herpetiformis
Last Crawled2026-04-17 22:29:30 (5 days ago)
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Meta TitleDermatitis Herpetiformis | Johns Hopkins Medicine
Meta DescriptionDermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and bumps.
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Skin What is dermatitis herpetiformis (DH)? Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and bumps. It typically affects people in their 30s to 50s, but it can happen at any age. This lifelong condition affects more men than women. What causes dermatitis herpetiformis? Despite its name, the herpes virus does not cause DH. DH is caused by a sensitivity or intolerance to gluten. Gluten is a protein found in wheat and grains. When you have DH and eat food with gluten, the gluten combines with an antibody from the intestines. As the gluten and antibody circulate in the blood, they clog small blood vessels in the skin. This is what causes the rash. Who is at risk for dermatitis herpetiformis? DH is found most often in people of northern European heritage. The following diseases increase your risk of DH: Autoimmune thyroid disease Celiac disease Type 1 diabetes Sjögren syndrome Lupus What are the symptoms of dermatitis herpetiformis? The following are the most common symptoms of DH. However, each person may experience symptoms differently. Symptoms may include: Clusters of itchy, small blisters and bumps, mostly on the elbows, lower back, buttocks, knees, and back of the head Severe itching and burning Erosions and scratches are often seen on the skin The gut may also have the same allergy to gluten. This is known as celiac disease. You can have both DH and celiac. Some cases of celiac become cancerous. Because of this, if you have celiac disease, it is important to see a healthcare provider who specializes in the stomach and intestines (a gastroenterologist). The symptoms of DH may look like other skin conditions. Always talk with your healthcare provider for a diagnosis. How is dermatitis herpetiformis diagnosed? In addition to a medical history and physical exam, DH is usually confirmed with a skin biopsy and a specialized type of immunofluorescent stain that helps to detect the IgA antibodies. You may also have a blood tests to find certain antibodies. How is dermatitis herpetiformis treated? DH may be well-controlled with treatment. Specific treatment will be determined by your healthcare provider based on: Your age, overall health, and medical history Extent of the condition Your tolerance for specific medicines, procedures, and therapies Expectation for the course of the condition Your opinion or preference The symptoms of DH may go away if you cut all gluten from your diet. Healing may take several weeks to months. Your healthcare provider may also prescribe a medicine called dapsone. This medicine suppresses the skin response and may improve symptoms. However, the medicine has some side effects, including anemia. If dapsone is prescribed for you, your healthcare provider will carefully monitor your blood count. Can dermatitis herpetiformis be prevented? There is no known way to prevent this disease. You may be able to prevent complications by avoiding foods that contain gluten. Although difficult, sticking to a gluten-free diet can reduce the amount of medicines needed to manage the disease. What are the complications of dermatitis herpetiformis? People with DH often have celiac disease, which may develop into intestinal cancer. Thyroid disease may also develop. Living with dermatitis herpetiformis It is important to follow your healthcare provider’s recommendations about a gluten-free diet and medicines. Iodine and some nonsteroidal anti-inflammatory medicines (NSAIDs) can trigger the condition. So, you may be told to avoid iodized salt and certain NSAIDs. When should I call my healthcare provider? If your symptoms worsen or you develop new symptoms, call your healthcare provider. Key points about dermatitis herpetiformis Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and small bumps. DH is caused by a sensitivity to gluten. The symptoms of DH may clear when all gluten is cut from the diet.
Markdown
[Skip to Main Content](https://www.hopkinsmedicine.org/health/conditions-and-diseases/dermatitis-herpetiformis#skip) [![Johns Hopkins Medicine](https://www.hopkinsmedicine.org/-/media/images/hopkins-medicine-logo-white-header.svg?iar=0&hash=C6173D209DB591FDF4EFE00B18C2FFE4)](https://www.hopkinsmedicine.org/) Johns Hopkins Medicine Menu - [Health](https://www.hopkinsmedicine.org/health) - [School of Medicine](https://www.hopkinsmedicine.org/som) - [Johns Hopkins Medicine Home](https://www.hopkinsmedicine.org/) - [About](https://www.hopkinsmedicine.org/about) - [Patient Care](https://www.hopkinsmedicine.org/patient-care) - [Research](https://www.hopkinsmedicine.org/research) - [MyChart](https://mychart.hopkinsmedicine.org/) - [Schedule an Appointment](https://www.hopkinsmedicine.org/patient-care/johns-hopkins-medicine-request-appointment) - [Find a Doctor](https://www.hopkinsmedicine.org/profiles) - [Find a Clinical Trial](https://www.hopkinsmedicine.org/clinical-trials) - [Pay Your Bill](https://www.hopkinsmedicine.org/patient-care/patients-visitors/billing-insurance/pay-bill) - [Employment](https://www.hopkinsmedicine.org/employment) Close Search Close [MyChart Login MyChart](https://mychart.hopkinsmedicine.org/) [Home](https://www.hopkinsmedicine.org/) [Health Home](https://www.hopkinsmedicine.org/health) [Conditions and Diseases](https://www.hopkinsmedicine.org/health/conditions-and-diseases) # Dermatitis Herpetiformis [Skin](https://www.hopkinsmedicine.org/health/skin) ## What is dermatitis herpetiformis (DH)? Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and bumps. It typically affects people in their 30s to 50s, but it can happen at any age. This lifelong condition affects more men than women. ## What causes dermatitis herpetiformis? Despite its name, the [herpes virus](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/infectious_diseases/Herpes_HSV-1_and_HSV-2_22,HerpesHSV-1andHSV-2) does not cause DH. DH is caused by a sensitivity or intolerance to gluten. Gluten is a protein found in wheat and grains. When you have DH and eat food with gluten, the gluten combines with an antibody from the intestines. As the gluten and antibody circulate in the blood, they clog small blood vessels in the skin. This is what causes the rash. ## Who is at risk for dermatitis herpetiformis? DH is found most often in people of northern European heritage. The following diseases increase your risk of DH: - Autoimmune thyroid disease - [Celiac disease](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/digestive_disorders/celiac_disease_85,P00361) - [Type 1 diabetes](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/endocrinology/type_1_diabetes_85,p00355) - [Sjögren syndrome](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/arthritis_and_other_rheumatic_diseases/Sjogrens_Syndrome_22,SjogrensSyndrome) - [Lupus](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/arthritis_and_other_rheumatic_diseases/systemic_lupus_erythematosus_lupus_85,P00058) ## What are the symptoms of dermatitis herpetiformis? The following are the most common symptoms of DH. However, each person may experience symptoms differently. Symptoms may include: - Clusters of itchy, small blisters and bumps, mostly on the elbows, lower back, buttocks, knees, and back of the head - Severe itching and burning - Erosions and scratches are often seen on the skin The gut may also have the same allergy to gluten. This is known as celiac disease. You can have both DH and celiac. Some cases of celiac become cancerous. Because of this, if you have celiac disease, it is important to see a healthcare provider who specializes in the stomach and intestines (a gastroenterologist). The symptoms of DH may look like other skin conditions. Always talk with your healthcare provider for a diagnosis. ## How is dermatitis herpetiformis diagnosed? In addition to a medical history and physical exam, DH is usually confirmed with a skin biopsy and a specialized type of immunofluorescent stain that helps to detect the IgA antibodies. You may also have a blood tests to find certain antibodies. ## How is dermatitis herpetiformis treated? DH may be well-controlled with treatment. Specific treatment will be determined by your healthcare provider based on: - Your age, overall health, and medical history - Extent of the condition - Your tolerance for specific medicines, procedures, and therapies - Expectation for the course of the condition - Your opinion or preference The symptoms of DH may go away if you cut all gluten from your diet. Healing may take several weeks to months. Your healthcare provider may also prescribe a medicine called dapsone. This medicine suppresses the skin response and may improve symptoms. However, the medicine has some side effects, including anemia. If dapsone is prescribed for you, your healthcare provider will carefully monitor your blood count. ## Can dermatitis herpetiformis be prevented? There is no known way to prevent this disease. You may be able to prevent complications by avoiding foods that contain gluten. Although difficult, sticking to a gluten-free diet can reduce the amount of medicines needed to manage the disease. ## What are the complications of dermatitis herpetiformis? People with DH often have celiac disease, which may develop into intestinal cancer. Thyroid disease may also develop. ## Living with dermatitis herpetiformis It is important to follow your healthcare provider’s recommendations about a gluten-free diet and medicines. Iodine and some nonsteroidal anti-inflammatory medicines (NSAIDs) can trigger the condition. So, you may be told to avoid iodized salt and certain NSAIDs. ## When should I call my healthcare provider? If your symptoms worsen or you develop new symptoms, call your healthcare provider. ## Key points about dermatitis herpetiformis - Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and small bumps. - DH is caused by a sensitivity to gluten. - The symptoms of DH may clear when all gluten is cut from the diet. ## Find a Doctor Specializing In: - [Dermatology](https://profiles.hopkinsmedicine.org/search?unified="Dermatology"&sort=networks%2Crelevance%2Cavailability_density_best) - [Pediatric Dermatology](https://profiles.hopkinsmedicine.org/search?unified="Pediatric+Dermatology"&sort=networks%2Crelevance%2Cavailability_density_best) ## Find a Treatment Center - [Dermatology](http://www.hopkinsmedicine.org/dermatology) Find Additional Treatment Centers at: - [Howard County Medical Center](https://www.hopkinsmedicine.org/johns-hopkins-howard-county) - [Sibley Memorial Hospital](https://www.hopkinsmedicine.org/sibley-memorial-hospital) - [Suburban Hospital](https://www.hopkinsmedicine.org/suburban-hospital) ## Related ![Interview with Joseph Perno, M.D.](https://www.hopkinsmedicine.org/-/media/images/health/1_-conditions/skin/common-rashes-in-kids-teaser.jpg?h=320&iar=0&w=560&hash=E0356D143E43B436504C228A5FE45FDB) - [Common Pediatric Rashes](https://www.hopkinsmedicine.org/health/conditions-and-diseases/skin-conditions/common-pediatric-rashes) - [What Is Hand, Foot and Mouth Disease?](https://www.hopkinsmedicine.org/health/conditions-and-diseases/skin-conditions/what-is-hand-foot-and-mouth-disease) - [Folliculitis, Boils and Carbuncles](https://www.hopkinsmedicine.org/health/conditions-and-diseases/folliculitis-boils-and-carbuncles) - [Merkel Cell Carcinoma](https://www.hopkinsmedicine.org/health/conditions-and-diseases/merkel-cell-carcinoma) ![](https://www.hopkinsmedicine.org/-/media/project/jhm/icons/jhmcalendar.svg?iar=0&hash=9758E8BED5D3E0BEC4202D7B92AC5624) ## Request an Appointment [Find a Doctor](https://www.hopkinsmedicine.org/profiles) - [410-955-5000](tel:410-955-5000) Maryland - [855-695-4872](tel:855-695-4872) Outside of Maryland - [\+1-410-502-7683](tel:+1-410-502-7683) International [Find a Doctor](https://www.hopkinsmedicine.org/profiles) See More ## Find a Doctor Specializing In: - [Dermatology](https://profiles.hopkinsmedicine.org/search?unified="Dermatology"&sort=networks%2Crelevance%2Cavailability_density_best) - [Pediatric Dermatology](https://profiles.hopkinsmedicine.org/search?unified="Pediatric+Dermatology"&sort=networks%2Crelevance%2Cavailability_density_best) ## Find a Treatment Center - [Dermatology](http://www.hopkinsmedicine.org/dermatology) Find Additional Treatment Centers at: - [Howard County Medical Center](https://www.hopkinsmedicine.org/johns-hopkins-howard-county) - [Sibley Memorial Hospital](https://www.hopkinsmedicine.org/sibley-memorial-hospital) - [Suburban Hospital](https://www.hopkinsmedicine.org/suburban-hospital) ## Related - [![Interview with Joseph Perno, M.D.](https://www.hopkinsmedicine.org/-/media/images/health/1_-conditions/skin/common-rashes-in-kids-teaser.jpg?h=217&iar=0&mh=260&mw=380&w=380&hash=6FD21AE05AA53319B5D63625AD81A89B) Skin Common Pediatric Rashes](https://www.hopkinsmedicine.org/health/conditions-and-diseases/skin-conditions/common-pediatric-rashes) - [![Ebony Hunter, M.D.](https://www.hopkinsmedicine.org/-/media/images/health/1_-conditions/skin/what-is-hand-foot-and-mouth-disease-teaser.jpg?h=217&iar=0&mh=260&mw=380&w=380&hash=C3E0193052A4055D4E3A895A17BC0694) Skin What Is Hand, Foot and Mouth Disease?](https://www.hopkinsmedicine.org/health/conditions-and-diseases/skin-conditions/what-is-hand-foot-and-mouth-disease) - [![Woman with a large boil on her chin](https://www.hopkinsmedicine.org/-/media/images/health/1_-conditions/skin/patient-with-large-boil-on-chin-teaser.jpg?h=217&iar=0&mh=260&mw=380&w=380&hash=85CE0F0CFDF5F0109F1E46C0BADA1259) Skin Folliculitis, Boils and Carbuncles](https://www.hopkinsmedicine.org/health/conditions-and-diseases/folliculitis-boils-and-carbuncles) ## Related Topics - [Skin](https://www.hopkinsmedicine.org/health/skin) ## [![Johns Hopkins Medicine](https://www.hopkinsmedicine.org/-/media/images/hopkins-nav-logo.svg)](https://www.hopkinsmedicine.org/) Language Assistance Available: - [Español](https://www.hopkinsmedicine.org/patient-care/patients-visitors/language-assistance-services#spanish) - 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Readable Markdown
[Skin](https://www.hopkinsmedicine.org/health/skin) ## What is dermatitis herpetiformis (DH)? Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and bumps. It typically affects people in their 30s to 50s, but it can happen at any age. This lifelong condition affects more men than women. ## What causes dermatitis herpetiformis? Despite its name, the [herpes virus](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/infectious_diseases/Herpes_HSV-1_and_HSV-2_22,HerpesHSV-1andHSV-2) does not cause DH. DH is caused by a sensitivity or intolerance to gluten. Gluten is a protein found in wheat and grains. When you have DH and eat food with gluten, the gluten combines with an antibody from the intestines. As the gluten and antibody circulate in the blood, they clog small blood vessels in the skin. This is what causes the rash. ## Who is at risk for dermatitis herpetiformis? DH is found most often in people of northern European heritage. The following diseases increase your risk of DH: - Autoimmune thyroid disease - [Celiac disease](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/digestive_disorders/celiac_disease_85,P00361) - [Type 1 diabetes](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/endocrinology/type_1_diabetes_85,p00355) - [Sjögren syndrome](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/arthritis_and_other_rheumatic_diseases/Sjogrens_Syndrome_22,SjogrensSyndrome) - [Lupus](https://www.hopkinsmedicine.org/healthlibrary/conditions/adult/arthritis_and_other_rheumatic_diseases/systemic_lupus_erythematosus_lupus_85,P00058) ## What are the symptoms of dermatitis herpetiformis? The following are the most common symptoms of DH. However, each person may experience symptoms differently. Symptoms may include: - Clusters of itchy, small blisters and bumps, mostly on the elbows, lower back, buttocks, knees, and back of the head - Severe itching and burning - Erosions and scratches are often seen on the skin The gut may also have the same allergy to gluten. This is known as celiac disease. You can have both DH and celiac. Some cases of celiac become cancerous. Because of this, if you have celiac disease, it is important to see a healthcare provider who specializes in the stomach and intestines (a gastroenterologist). The symptoms of DH may look like other skin conditions. Always talk with your healthcare provider for a diagnosis. ## How is dermatitis herpetiformis diagnosed? In addition to a medical history and physical exam, DH is usually confirmed with a skin biopsy and a specialized type of immunofluorescent stain that helps to detect the IgA antibodies. You may also have a blood tests to find certain antibodies. ## How is dermatitis herpetiformis treated? DH may be well-controlled with treatment. Specific treatment will be determined by your healthcare provider based on: - Your age, overall health, and medical history - Extent of the condition - Your tolerance for specific medicines, procedures, and therapies - Expectation for the course of the condition - Your opinion or preference The symptoms of DH may go away if you cut all gluten from your diet. Healing may take several weeks to months. Your healthcare provider may also prescribe a medicine called dapsone. This medicine suppresses the skin response and may improve symptoms. However, the medicine has some side effects, including anemia. If dapsone is prescribed for you, your healthcare provider will carefully monitor your blood count. ## Can dermatitis herpetiformis be prevented? There is no known way to prevent this disease. You may be able to prevent complications by avoiding foods that contain gluten. Although difficult, sticking to a gluten-free diet can reduce the amount of medicines needed to manage the disease. ## What are the complications of dermatitis herpetiformis? People with DH often have celiac disease, which may develop into intestinal cancer. Thyroid disease may also develop. ## Living with dermatitis herpetiformis It is important to follow your healthcare provider’s recommendations about a gluten-free diet and medicines. Iodine and some nonsteroidal anti-inflammatory medicines (NSAIDs) can trigger the condition. So, you may be told to avoid iodized salt and certain NSAIDs. ## When should I call my healthcare provider? If your symptoms worsen or you develop new symptoms, call your healthcare provider. ## Key points about dermatitis herpetiformis - Dermatitis herpetiformis (DH) is an intensely itchy skin disease. It causes clusters of small blisters and small bumps. - DH is caused by a sensitivity to gluten. - The symptoms of DH may clear when all gluten is cut from the diet.
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Publish Time2019-11-19 00:00:00 (6 years ago)
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