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| Meta Title | Melatonin for Sleep: Uses, Dosage, Side Effects, and More |
| Meta Description | Learn about the effectiveness of melatonin for sleep. Discover whether supplements are safe, melatonin's role in pregnancy and for kids, and more. |
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| Boilerpipe Text | There is strong evidence that melatonin has benefits for sleep. It may increase the duration and quality of your sleep and help with insomnia. Dosage determines how it will affect your sleep.
Melatonin is a hormone that your body
makes naturally
. It’s often called the sleep hormone, as high levels can help you fall asleep.
However, melatonin itself won’t put you to sleep. It
lets your body know
that it’s time for bed so that you can fall asleep more easily.
Keep reading to learn more about its benefits, as well as potential side effects and risks for certain populations.
It lets you know when it’s time to sleep, wake up, and more.
Melatonin also
helps
regulate:
blood pressure
blood glucose
body weight
hormone levels
body temperature
Because melatonin helps your body prepare for sleep, people who don’t make enough of it at night can have trouble falling asleep.
Many factors
may cause
low melatonin levels at night, such as:
alcohol consumption
smoking
caffeine consumption
shift work
aging
certain medications
blue light
exposure
Taking a melatonin supplement may help counter low levels and normalize your internal clock.
It is important to speak with a doctor first to determine if taking melatonin is the best option for you.
A
2019 review
of 11 studies demonstrated that taking melatonin before bed decreased sleep latency by almost 3 minutes and increased total sleep time by about 30 minutes, compared with a placebo.
A
2021 review
of 23 studies involving people with disease-related sleep disorders found that melatonin significantly reduced sleep disturbances and sleep latency while increasing sleep duration and quality.
Additionally, melatonin may
counteract jet lag
by
syncing your internal clock
with the time change. Shift workers
may
experience jet lag symptoms because they work during hours that are normally used for sleep.
establishing a consistent sleep schedule
limiting alcohol and caffeine consumption
refraining from using electronic devices before bed
In addition to improving sleep, melatonin may help manage other health conditions.
Eye health:
A
2019 study
found that melatonin supplements may reduce age-related macular degeneration by neutralizing free radicals and decreasing inflammation due to its antioxidant effects in the body.
Acid reflux and GERD:
Melatonin
may help
alleviate acid reflux and gastroesophageal reflux (GERD) by protecting the lining of your esophagus against irritants such as acid, alcohol, and nonsteroidal anti-inflammatory drugs.
Tinnitus:
Researchers
suggest that taking melatonin may reduce significant tinnitus symptoms.
Migraine attacks:
Melatonin may
offer relief
due to its ability to inhibit pain sensations.
Brain health:
Studies
suggest that melatonin improves sleep quality and morning alertness in individuals with Alzheimer’s disease. However, more research is needed to understand melatonin’s effect on the brain.
If you’re considering trying melatonin for insomnia, start with a low dose supplement.
For instance, start with 0.5 to 1 milligrams (mg) 30 minutes before going to bed. If that doesn’t seem to help you fall asleep, try increasing your dose to 3 to 5 mg.
Taking melatonin in excess of 5 mg is unlikely to help you fall asleep faster. The goal is to find the lowest dose that helps you sleep.
It’s best to follow the supplement instructions. Talk with your doctor before adding over-the-counter melatonin to your routine.
Research
suggests that melatonin supplements are safe, nontoxic, and not addictive for either children or adults.
Studies
have found no significant adverse events associated with daily melatonin intake in dosages of 2 to 10 mg for up to 3.5 years. No evidence suggests that taking melatonin affects your body’s natural ability to make its own.
daytime sleepiness
fatigue
dizziness
headaches
nausea
a cold feeling
Melatonin may interact with a variety of medications by either altering their effectiveness or increasing the risk of side effects.
Medications that melatonin may interact with include:
sleep aids or sedatives
blood thinners
anticonvulsants
blood pressure medications
antidepressants
oral contraceptives
diabetes medications
immunosuppressants
If you take any of the above medications, talk with your doctor before starting melatonin.
Melatonin may also interact with alcohol. Some
research from 2024
suggests that moderate to heavy alcohol use reduces melatonin levels and disrupts sleep quality, but results are mixed.
During pregnancy
, melatonin
transfers
to your developing baby. Melatonin contributes to the development of circadian rhythms and both the nervous and endocrine systems.
Melatonin may also
protect
the fetal nervous system by safeguarding the baby’s developing nervous system from
oxidative stress
.
However, few studies have examined melatonin supplementation during pregnancy, so taking melatonin supplements during pregnancy is
not recommended
.
Additionally, no data exists on the safety of melatonin supplementation during breastfeeding. For this reason, using melatonin supplements while nursing is
also not recommended
.
A
2019 review
on melatonin use in children and adolescents found that children receiving melatonin as a short-term treatment fell asleep faster and slept longer than children receiving a placebo.
A
2018 study
followed 69 people who had been using melatonin since childhood, for about 11 years. It found that sleep quality wasn’t notably different from those who hadn’t used melatonin.
Tolerance, dosage, and precautions
While
some research
suggests that long-term melatonin use may delay puberty — as a natural decline in evening melatonin levels is associated with the onset of puberty — more research is needed.
Because researchers don’t yet understand the long-term effects of melatonin use in children, it may be best to help your kids
implement good sleep practices
first before trying melatonin.
Talk to your child’s pediatrician before starting them on melatonin. They will be able to take your child’s individual needs into account and inform you about appropriate dosage if melatonin is an appropriate option for your child.
Melatonin is a supplement that may help you fall asleep, especially if you have
insomnia
or jet lag. It may also offer other health benefits.
If you’re considering melatonin, talk with a doctor or pharmacist first to find out whether it’s right for you and whether it might interact with any medications you’re taking.
Then, you can start with a low dose of 0.5 to 1 mg 30 minutes before bed. If that doesn’t help, try increasing your dose to 3 to 5 mg.
Melatonin is generally well tolerated, although
mild side effects
are possible. |
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Evidence Based
# What Does Melatonin Do, and How Does It Work?

[Medically reviewed]() by [Angelica Balingit, MD]() — Written by [Gavin Van De Walle, MS, RD]() and Ryan Raman, MS, RD and [Jill Seladi-Schulman, Ph.D.]() — [Updated on January 2, 2025]()
- [How it works](https://www.healthline.com/nutrition/melatonin-and-sleep#how-it-works)
- [Effect on sleep](https://www.healthline.com/nutrition/melatonin-and-sleep#effect-on-sleep)
- [Other benefits](https://www.healthline.com/nutrition/melatonin-and-sleep#other-benefits)
- [Dosage](https://www.healthline.com/nutrition/melatonin-and-sleep#dosage)
- [Side effects](https://www.healthline.com/nutrition/melatonin-and-sleep#side-effects)
- [Interactions](https://www.healthline.com/nutrition/melatonin-and-sleep#interactions)
- [During pregnancy](https://www.healthline.com/nutrition/melatonin-and-sleep#during-pregnancy)
- [For kids](https://www.healthline.com/nutrition/melatonin-and-sleep#for-kids)
- [Takeaway](https://www.healthline.com/nutrition/melatonin-and-sleep#takeaway)
There is strong evidence that melatonin has benefits for sleep. It may increase the duration and quality of your sleep and help with insomnia. Dosage determines how it will affect your sleep.
Melatonin is a hormone that your body [makes naturally](https://academic.oup.com/edrv/article/39/6/990/5094958). It’s often called the sleep hormone, as high levels can help you fall asleep.
However, melatonin itself won’t put you to sleep. It [lets your body know](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646716/) that it’s time for bed so that you can fall asleep more easily.
Keep reading to learn more about its benefits, as well as potential side effects and risks for certain populations.
## [How does melatonin work?]()
Melatonin [works](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057895/) with your body’s [circadian rhythm](https://www.healthline.com/health/healthy-sleep/circadian-rhythm).
It lets you know when it’s time to sleep, wake up, and more.
Melatonin also [helps](https://www.ncbi.nlm.nih.gov/books/NBK534823/) regulate:
- blood pressure
- blood glucose
- body weight
- hormone levels
- [body temperature](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767594/)
Because melatonin helps your body prepare for sleep, people who don’t make enough of it at night can have trouble falling asleep.
Many factors [may cause](https://www.ncbi.nlm.nih.gov/books/NBK550972/table/neuroendo_pinealmel.T.factors_influencin/) low melatonin levels at night, such as:
- alcohol consumption
- smoking
- caffeine consumption
- shift work
- aging
- certain medications
- [blue light](https://www.healthline.com/nutrition/block-blue-light-to-sleep-better) exposure
Taking a melatonin supplement may help counter low levels and normalize your internal clock.
It is important to speak with a doctor first to determine if taking melatonin is the best option for you.
## [Taking melatonin for sleep may help]()
A [2019 review](https://pubmed.ncbi.nlm.nih.gov/29908879/) of 11 studies demonstrated that taking melatonin before bed decreased sleep latency by almost 3 minutes and increased total sleep time by about 30 minutes, compared with a placebo.
A [2021 review](https://pubmed.ncbi.nlm.nih.gov/33417003/) of 23 studies involving people with disease-related sleep disorders found that melatonin significantly reduced sleep disturbances and sleep latency while increasing sleep duration and quality.
Additionally, melatonin may [counteract jet lag](https://www.healthline.com/health/melatonin-for-jet-lag) by [syncing your internal clock](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182450/) with the time change. Shift workers [may](https://www.sciencedirect.com/science/article/abs/pii/S1389945720304214?via%3Dihub) experience jet lag symptoms because they work during hours that are normally used for sleep.
Before using melatonin, though, try [implementing healthy sleep habits](https://www.healthline.com/nutrition/17-tips-to-sleep-better), such as:
- establishing a consistent sleep schedule
- limiting alcohol and caffeine consumption
- refraining from using electronic devices before bed
## [Additional melatonin health benefits]()
In addition to improving sleep, melatonin may help manage other health conditions.
- **Eye health:** A
[2019 study](https://pubmed.ncbi.nlm.nih.gov/31724508/)
found that melatonin supplements may reduce age-related macular degeneration by neutralizing free radicals and decreasing inflammation due to its antioxidant effects in the body.
- **Acid reflux and GERD:** Melatonin
[may help](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073539/)
alleviate acid reflux and gastroesophageal reflux (GERD) by protecting the lining of your esophagus against irritants such as acid, alcohol, and nonsteroidal anti-inflammatory drugs.
- **Tinnitus:** [Researchers](https://www.researchgate.net/profile/Giuseppe-Lippi/publication/380066686_Effect_of_melatonin_supplementation_on_tinnitus_Systematic_literature_review_and_meta-analysis/links/66292a03352430415340913e/Effect-of-melatonin-supplementation-on-tinnitus-Systematic-literature-review-and-meta-analysis.pdf) suggest that taking melatonin may reduce significant tinnitus symptoms.
- **Migraine attacks:** Melatonin may
[offer relief](https://pubmed.ncbi.nlm.nih.gov/32352572/)
due to its ability to inhibit pain sensations.
- **Brain health:**
[Studies](https://pubmed.ncbi.nlm.nih.gov/39128995/)
suggest that melatonin improves sleep quality and morning alertness in individuals with Alzheimer’s disease. However, more research is needed to understand melatonin’s effect on the brain.
## [How to take melatonin]()
If you’re considering trying melatonin for insomnia, start with a low dose supplement.
For instance, start with 0.5 to 1 milligrams (mg) 30 minutes before going to bed. If that doesn’t seem to help you fall asleep, try increasing your dose to 3 to 5 mg.
Taking melatonin in excess of 5 mg is unlikely to help you fall asleep faster. The goal is to find the lowest dose that helps you sleep.
It’s best to follow the supplement instructions. Talk with your doctor before adding over-the-counter melatonin to your routine.
## [Melatonin side effects]()
[Research](https://www.ncbi.nlm.nih.gov/books/NBK534823/) suggests that melatonin supplements are safe, nontoxic, and not addictive for either children or adults.
[Studies](https://www.sciencedirect.com/science/article/abs/pii/S0965229918309373?via%3Dihub) have found no significant adverse events associated with daily melatonin intake in dosages of 2 to 10 mg for up to 3.5 years. No evidence suggests that taking melatonin affects your body’s natural ability to make its own.
However, several [short-lived side effects](https://www.healthline.com/nutrition/melatonin-side-effects) of melatonin supplements have been reported, [including](https://pubmed.ncbi.nlm.nih.gov/31722088/):
- daytime sleepiness
- [fatigue](https://www.healthline.com/nutrition/10-reasons-you-are-tired)
- dizziness
- headaches
- nausea
- a cold feeling
## [Melatonin interactions]()
Melatonin may interact with a variety of medications by either altering their effectiveness or increasing the risk of side effects.
Medications that melatonin may interact with include:
- [sleep aids or sedatives](https://www.ncbi.nlm.nih.gov/books/NBK534823/)
- blood thinners
- anticonvulsants
- [blood pressure medications](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/)
- [antidepressants](https://www.nhs.uk/medicines/melatonin/taking-melatonin-with-other-medicines-and-herbal-supplements/)
- oral contraceptives
- diabetes medications
- immunosuppressants
If you take any of the above medications, talk with your doctor before starting melatonin.
Melatonin may also interact with alcohol. Some [research from 2024](https://www.sciencedirect.com/science/article/abs/pii/S0278584619303975?via%3Dihub) suggests that moderate to heavy alcohol use reduces melatonin levels and disrupts sleep quality, but results are mixed.
## [Melatonin and pregnancy]()
[During pregnancy](https://www.healthline.com/health/pregnancy/melatonin-pregnancy), melatonin [transfers](https://www.sciencedirect.com/science/article/abs/pii/S0890623824000017?via%3Dihub) to your developing baby. Melatonin contributes to the development of circadian rhythms and both the nervous and endocrine systems.
Melatonin may also [protect](https://www.sciencedirect.com/science/article/abs/pii/S0890623824000017?via%3Dihub) the fetal nervous system by safeguarding the baby’s developing nervous system from [oxidative stress](https://www.healthline.com/health/oxidative-stress).
However, few studies have examined melatonin supplementation during pregnancy, so taking melatonin supplements during pregnancy is [not recommended](https://www.ncbi.nlm.nih.gov/books/NBK534823/).
Additionally, no data exists on the safety of melatonin supplementation during breastfeeding. For this reason, using melatonin supplements while nursing is [also not recommended](https://www.ncbi.nlm.nih.gov/books/NBK501863/).
## [Melatonin and children]()
The effectiveness of [melatonin in children and adolescents](https://www.healthline.com/nutrition/melatonin-for-kids) is still being investigated.
A [2019 review](https://pubmed.ncbi.nlm.nih.gov/31982807/) on melatonin use in children and adolescents found that children receiving melatonin as a short-term treatment fell asleep faster and slept longer than children receiving a placebo.
A [2018 study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872230/) followed 69 people who had been using melatonin since childhood, for about 11 years. It found that sleep quality wasn’t notably different from those who hadn’t used melatonin.
### Tolerance, dosage, and precautions
While [some research](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/) suggests that long-term melatonin use may delay puberty — as a natural decline in evening melatonin levels is associated with the onset of puberty — more research is needed.
Because researchers don’t yet understand the long-term effects of melatonin use in children, it may be best to help your kids [implement good sleep practices](https://www.healthline.com/health/tips-get-your-kids-sleep) first before trying melatonin.
Talk to your child’s pediatrician before starting them on melatonin. They will be able to take your child’s individual needs into account and inform you about appropriate dosage if melatonin is an appropriate option for your child.
## [The takeaway]()
Melatonin is a supplement that may help you fall asleep, especially if you have [insomnia](https://www.healthline.com/health/insomnia) or jet lag. It may also offer other health benefits.
If you’re considering melatonin, talk with a doctor or pharmacist first to find out whether it’s right for you and whether it might interact with any medications you’re taking.
Then, you can start with a low dose of 0.5 to 1 mg 30 minutes before bed. If that doesn’t help, try increasing your dose to 3 to 5 mg.
Melatonin is generally well tolerated, although [mild side effects](https://www.healthline.com/nutrition/melatonin-side-effects) are possible.
## [Food fix: Foods for better sleep]()
### How we reviewed this article:
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### Evidence Based
This article is based on scientific evidence, written by [experts](https://www.healthline.com/nutrition-team) and fact checked by experts.
Our team of licensed nutritionists and dietitians strive to be objective, unbiased, honest and to present both sides of the argument.
This article contains scientific references. The numbers in the parentheses (1, 2, 3) are clickable links to peer-reviewed scientific papers.

[Medically reviewed]() by [Angelica Balingit, MD]() — Written by [Gavin Van De Walle, MS, RD]() and Ryan Raman, MS, RD and [Jill Seladi-Schulman, Ph.D.]() — [Updated on January 2, 2025]()
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