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| Meta Title | Is It Bad to Take Melatonin Every Night? Are There Risks? |
| Meta Description | The short-term use of melatonin supplements appears to be safe for most adults and children. Learn more about what’s known regarding taking melatonin every night. |
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| Boilerpipe Text | Melatonin can be an effective tool for improving sleep quality. However, it’s important to pay attention to dosage and consider potential risks and side effects.
Melatonin
is a hormone that your body naturally produces. It plays a role in regulating your sleep-wake cycle.
There’s also a lab-made version of melatonin that’s available as an over-the-counter supplement. Some people use
melatonin supplements
to help with sleep problems like jet lag and insomnia.
In this article, we’ll explore how exactly melatonin works and whether it’s safe to take melatonin supplements every night.
Natural melatonin is predominantly made in your
pineal gland
, which is located in your brain. Light exposure inhibits the production of melatonin, but darkness stimulates it.
Melatonin levels in your brain begin to increase at dusk as the sun goes down and darkness falls. They reach their peak levels in the middle of the night and start decreasing as dawn gets closer.
Melatonin inhibits signals in the brain that promote wakefulness. This helps encourage sleep by making you feel tired or drowsy as you get closer to bedtime.
Because of melatonin’s sleep-promoting effects, melatonin supplements are used to treat a variety of sleep problems. These can include:
insomnia
jet lag
shift work sleep disorder
delayed sleep-wake phase disorder
sleep problems in children with
autism
or
attention deficit hyperactivity disorder (ADHD)
The Food and Drug Administration (FDA) doesn’t regulate melatonin as a drug. Because of this, there’s limited information on the optimal, safe dosage of melatonin.
In fact, the doses of melatonin supplements that have been used in various scientific studies vary widely, from
0.1 to 10 milligrams (mg)
. One 2017 review defines a typical dose of melatonin to be between
1 and 5 mg
.
Melatonin typically takes
1 to 2 hours
to work, so it’s often taken up to 2 hours before bedtime.
If you’re looking to try melatonin for the first time, it may be best to begin with a lower dose. Your doctor can help recommend a safe dose for you to start with.
Melatonin for children
Like melatonin for adults, there’s not much information on the optimal, safe dosage
for children
. Dosage may also vary depending on a child’s age. One
2016 review
suggests the following age-based dosages 30 to 60 minutes before bedtime:
1 mg for infants
2.5 to 3 mg for older children
5 mg for adolescents
Because there aren’t clear dosing guidelines regarding melatonin for children, be sure to speak to your child’s pediatrician before giving melatonin to your child.
Melatonin for older adults
The amount of melatonin your body produces decreases with age. Because of this, melatonin supplements may be helpful for older adults who are
having trouble falling asleep
.
Researchers are still looking into the optimal melatonin dosage for older adults. One
2016 review
of sleep aids for older adults suggests a dosage of 1 to 2 mg of immediate-release melatonin 1 hour before bedtime.
What to know about dietary supplements and safety
The FDA classifies melatonin as a dietary supplement, meaning that it’s regulated less strictly than a regular drug. For dietary supplements, label claims and product safety don’t have to meet FDA approval before they’re marketed.
A
2017 study
of 31 different melatonin supplements found that the actual melatonin content of 71 percent of the products didn’t match the claim on the label. Additionally, 26 percent of products contained
serotonin
, which can be potentially harmful even in small doses.
When shopping for melatonin supplements, look for products that are “USP verified.”
The United States Pharmacopeia (USP)
is an independent organization that ensures
proper quality and dosing of dietary supplements.
You may be wondering what happens if you take a dose of melatonin and find that you still can’t fall asleep. Can you take another dose?
While taking an additional dose is
unlikely to cause harm
, it may increase your risk for experiencing unwanted side effects.
If you find that melatonin isn’t helping you fall asleep, stop using it. Your doctor may be able to suggest different medications or strategies to help you fall asleep.
Some studies
have indicated that long-term melatonin use in adults may cause mild side effects when compared to a placebo. Studies into the effects of long-term melatonin use in children remains limited.
Because melatonin levels naturally decrease at the beginning of puberty, there’s some concern that long-term melatonin use in children may delay puberty onset. However,
more research
is needed.
There are some important things to know about melatonin, its interactions with other substances, and when it’s best to avoid it. Let’s take a closer look.
What medications and substances does melatonin interact with?
Melatonin may interact with several different types of medications, including:
Blood-thinning medications.
Taking melatonin with
blood-thinning medication
may increase your risk for bleeding.
Epilepsy medications (anticonvulsants).
Melatonin may make
these medications
less effective.
Immunosuppressants.
Melatonin can potentially interfere with
immunosuppressive drugs
.
Diabetes medications.
Melatonin use can affect
blood sugar levels
.
Blood pressure medications.
Blood pressure may get worse when melatonin is taken with
these medications
.
Contraceptive drugs.
Birth control pills
may increase the risk of side effects from melatonin.
Because melatonin supplements can make you tired and drowsy, avoid mixing them with:
other sleep aids
central nervous system depressants
alcohol
There’s limited research into the safety of using melatonin supplements
during pregnancy
. Also, while melatonin is a normal component of breast milk, there’s little research into the effects of taking melatonin supplements while breastfeeding.
Because of this, it’s best to avoid taking melatonin if you’re:
pregnant
planning to become pregnant
breastfeeding
Additionally, it’s important to speak to your doctor before using melatonin if you have:
an
autoimmune condition
epilepsy
kidney disease
liver disease
had a previous
allergic reaction
to melatonin
It’s a good idea to schedule an appointment with your doctor or healthcare professional if you notice that you:
frequently have trouble falling asleep or staying asleep at night
often feel drowsy or tired during the day
have trouble performing your daily activities
Your doctor will work with you to discuss your
sleep routine
and lifestyle habits. They may also ask you to keep a sleep diary to track the amount of sleep you’re getting over a period of time.
It’s also possible that your doctor will perform a physical exam and order blood tests. These can help them rule out a medical condition that may be causing your sleep issues.
Melatonin supplements can be used to help promote sleep. Because there’s currently no standard dosage associated with melatonin supplements, talk to your doctor about how much melatonin to take and when.
Melatonin is generally safe for short-term use, but studies on its long-term effects are limited. Its side effects are typically mild.
If you take melatonin and notice that it isn’t helping you fall asleep or causes unwanted side effects, stop taking it and speak with your doctor. They can help recommend other strategies to help you get a good night’s sleep. |
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# Is It Safe to Take Melatonin Every Night?

[Medically reviewed]() by [Avi Varma, MD, MPH, AAHIVS, FAAFP]() — Written by [Jill Seladi-Schulman, Ph.D.]() — [Updated on September 27, 2024]()
- [How it works](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#how-it-works)
- [Dosages](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#dosages)
- [Side effects](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#side-effects)
- [Multiple doses](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#multiple-doses)
- [Every night usage](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#every-night-usage)
- [Interactions](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#interactions)
- [When to avoid](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#when-to-avoid)
- [When to seek care](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#when-to-seek-care)
- [Bottom line](https://www.healthline.com/health/is-it-bad-to-take-melatonin-every-night#bottom-line)
Melatonin can be an effective tool for improving sleep quality. However, it’s important to pay attention to dosage and consider potential risks and side effects.
[Melatonin](https://www.healthline.com/nutrition/melatonin-and-sleep) is a hormone that your body naturally produces. It plays a role in regulating your sleep-wake cycle.
There’s also a lab-made version of melatonin that’s available as an over-the-counter supplement. Some people use [melatonin supplements](https://www.healthline.com/nutrition/melatonin) to help with sleep problems like jet lag and insomnia.
In this article, we’ll explore how exactly melatonin works and whether it’s safe to take melatonin supplements every night.
## [How does melatonin work?]()
Natural melatonin is predominantly made in your [pineal gland](https://www.healthline.com/health/pineal-gland-function), which is located in your brain. Light exposure inhibits the production of melatonin, but darkness stimulates it.
Melatonin levels in your brain begin to increase at dusk as the sun goes down and darkness falls. They reach their peak levels in the middle of the night and start decreasing as dawn gets closer.
Melatonin inhibits signals in the brain that promote wakefulness. This helps encourage sleep by making you feel tired or drowsy as you get closer to bedtime.
Because of melatonin’s sleep-promoting effects, melatonin supplements are used to treat a variety of sleep problems. These can include:
- [insomnia](https://www.healthline.com/health/insomnia)
- [jet lag](https://www.healthline.com/health/melatonin-for-jet-lag)
- [shift work sleep disorder](https://www.healthline.com/health/shift-work-sleep-disorder)
- [delayed sleep-wake phase disorder](https://www.healthline.com/health/sleep-deprivation/delayed-sleep-phase-syndrome)
- sleep problems in children with [autism](https://www.healthline.com/health/autism-alternative-treatments#melatonin) or [attention deficit hyperactivity disorder (ADHD)](https://www.healthline.com/health/ahd/sleep-problems)
## [What’s a safe dosage?]()
The Food and Drug Administration (FDA) doesn’t regulate melatonin as a drug. Because of this, there’s limited information on the optimal, safe dosage of melatonin.
In fact, the doses of melatonin supplements that have been used in various scientific studies vary widely, from [0\.1 to 10 milligrams (mg)](https://www.ncbi.nlm.nih.gov/books/NBK534823/). One 2017 review defines a typical dose of melatonin to be between [1 and 5 mg](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/).
Melatonin typically takes [1 to 2 hours](https://www.nhs.uk/medicines/melatonin/) to work, so it’s often taken up to 2 hours before bedtime.
If you’re looking to try melatonin for the first time, it may be best to begin with a lower dose. Your doctor can help recommend a safe dose for you to start with.
### Melatonin for children
Like melatonin for adults, there’s not much information on the optimal, safe dosage [for children](https://www.healthline.com/nutrition/melatonin-for-kids). Dosage may also vary depending on a child’s age. One [2016 review](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830653/) suggests the following age-based dosages 30 to 60 minutes before bedtime:
- 1 mg for infants
- 2\.5 to 3 mg for older children
- 5 mg for adolescents
Because there aren’t clear dosing guidelines regarding melatonin for children, be sure to speak to your child’s pediatrician before giving melatonin to your child.
### Melatonin for older adults
The amount of melatonin your body produces decreases with age. Because of this, melatonin supplements may be helpful for older adults who are [having trouble falling asleep](https://www.healthline.com/health/sleep/sleep-disorders-in-the-elderly).
Researchers are still looking into the optimal melatonin dosage for older adults. One [2016 review](https://www.clinicaltherapeutics.com/article/S0149-2918\(16\)30733-0/fulltext) of sleep aids for older adults suggests a dosage of 1 to 2 mg of immediate-release melatonin 1 hour before bedtime.
### What to know about dietary supplements and safety
The FDA classifies melatonin as a dietary supplement, meaning that it’s regulated less strictly than a regular drug. For dietary supplements, label claims and product safety don’t have to meet FDA approval before they’re marketed.
A [2017 study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263083/) of 31 different melatonin supplements found that the actual melatonin content of 71 percent of the products didn’t match the claim on the label. Additionally, 26 percent of products contained [serotonin](https://www.healthline.com/health/mental-health/serotonin), which can be potentially harmful even in small doses.
When shopping for melatonin supplements, look for products that are “USP verified.” [The United States Pharmacopeia (USP)](https://www.usp.org/verification-services/verified-mark) is an independent organization that ensures proper quality and dosing of dietary supplements.
## [What happens if you take too much melatonin?]()
Melatonin is generally safe. However, mild [side effects](https://www.ncbi.nlm.nih.gov/books/NBK534823/) can sometimes occur, particularly if you take higher doses or extended-release formulations.
The [side effects](https://www.healthline.com/nutrition/melatonin-side-effects) of melatonin can include:
- feeling [drowsy](https://www.healthline.com/health/drowsiness) or sleepy
- [headache](https://www.healthline.com/health/headache)
- [dizziness](https://www.healthline.com/health/dizziness)
- [nausea](https://www.healthline.com/health/nausea)
- [increased urination](https://www.healthline.com/health/overactive-bladder-children) or [bedwetting](https://www.healthline.com/health/bedwetting) (children)
Some less common side effects of melatonin include:
- [irritability](https://www.healthline.com/health/irritability)
- [abdominal cramps](https://www.healthline.com/health/abdominal-pain)
- mild [tremors](https://www.healthline.com/health/tremor)
- feelings of [depression](https://www.healthline.com/health/melatonin-depression) or anxiety
- [confusion](https://www.healthline.com/health/confusion) or [disorientation](https://www.healthline.com/health/disorientation)
- low blood pressure ([hypotension](https://www.healthline.com/health/hypotension))
If you experience [side effects from melatonin](https://www.healthline.com/health/melatonin-overdose), stop taking it and speak with your doctor. They may recommend using a lower dose or trying out an alternative medication or [sleep aid](https://www.healthline.com/nutrition/sleep-aids).
## [Is it safe to take more than one dose during the night?]()
You may be wondering what happens if you take a dose of melatonin and find that you still can’t fall asleep. Can you take another dose?
While taking an additional dose is [unlikely to cause harm](https://www.nhs.uk/medicines/melatonin/), it may increase your risk for experiencing unwanted side effects.
If you find that melatonin isn’t helping you fall asleep, stop using it. Your doctor may be able to suggest different medications or strategies to help you fall asleep.
## [Are there any risks involved with taking melatonin every night?]()
According to the [National Center for Complementary and Integrative Health (NCCIH)](https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know), short-term use of melatonin supplements appears to be safe for most adults and children. However, information on the effects of long-term melatonin supplements is limited.
[Some studies](https://pubmed.ncbi.nlm.nih.gov/26692007/) have indicated that long-term melatonin use in adults may cause mild side effects when compared to a placebo. Studies into the effects of long-term melatonin use in children remains limited.
Because melatonin levels naturally decrease at the beginning of puberty, there’s some concern that long-term melatonin use in children may delay puberty onset. However, [more research](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/) is needed.
## [Can melatonin interact with other substances?]()
There are some important things to know about melatonin, its interactions with other substances, and when it’s best to avoid it. Let’s take a closer look.
### What medications and substances does melatonin interact with?
Melatonin may interact with several different types of medications, including:
- **Blood-thinning medications.** Taking melatonin with [blood-thinning medication](https://www.healthline.com/health/heart-disease/blood-thinners) may increase your risk for bleeding.
- **Epilepsy medications (anticonvulsants).** Melatonin may make [these medications](https://www.healthline.com/health/epilepsy/medications-list) less effective.
- **Immunosuppressants.** Melatonin can potentially interfere with [immunosuppressive drugs](https://www.healthline.com/health/immunosuppressant-drugs).
- **Diabetes medications.** Melatonin use can affect [blood sugar levels](https://www.healthline.com/health/type-2-diabetes/understanding-glucose-levels).
- **Blood pressure medications.** Blood pressure may get worse when melatonin is taken with [these medications](https://www.healthline.com/health/high-blood-pressure-hypertension-medication).
- **Contraceptive drugs.** [Birth control pills](https://www.healthline.com/health/birth-control/melatonin-and-birth-control) may increase the risk of side effects from melatonin.
Because melatonin supplements can make you tired and drowsy, avoid mixing them with:
- other sleep aids
- [central nervous system depressants](https://www.healthline.com/health/depression/cns-depression)
- [alcohol](https://www.healthline.com/health/melatonin-and-alcohol)
## [Are there any people who should avoid taking melatonin?]()
There’s limited research into the safety of using melatonin supplements [during pregnancy](https://www.healthline.com/health/pregnancy/melatonin-pregnancy). Also, while melatonin is a normal component of breast milk, there’s little research into the effects of taking melatonin supplements while breastfeeding.
Because of this, it’s best to avoid taking melatonin if you’re:
- pregnant
- planning to become pregnant
- breastfeeding
Additionally, it’s important to speak to your doctor before using melatonin if you have:
- an [autoimmune condition](https://www.healthline.com/health/autoimmune-disorders)
- [epilepsy](https://www.healthline.com/health/melatonin-and-epilepsy)
- [kidney disease](https://www.healthline.com/health/kidney-disease)
- [liver disease](https://www.healthline.com/health/liver-diseases)
- had a previous [allergic reaction](https://www.healthline.com/health/allergies/allergic-reaction) to melatonin
## [When to see your doctor about sleep issues]()
It’s a good idea to schedule an appointment with your doctor or healthcare professional if you notice that you:
- frequently have trouble falling asleep or staying asleep at night
- often feel drowsy or tired during the day
- have trouble performing your daily activities
Your doctor will work with you to discuss your [sleep routine](https://www.healthline.com/health/healthy-sleep/how-to-fix-sleep-schedule) and lifestyle habits. They may also ask you to keep a sleep diary to track the amount of sleep you’re getting over a period of time.
It’s also possible that your doctor will perform a physical exam and order blood tests. These can help them rule out a medical condition that may be causing your sleep issues.
## [The bottom line]()
Melatonin supplements can be used to help promote sleep. Because there’s currently no standard dosage associated with melatonin supplements, talk to your doctor about how much melatonin to take and when.
Melatonin is generally safe for short-term use, but studies on its long-term effects are limited. Its side effects are typically mild.
If you take melatonin and notice that it isn’t helping you fall asleep or causes unwanted side effects, stop taking it and speak with your doctor. They can help recommend other strategies to help you get a good night’s sleep.
### How we reviewed this article:
Sources
History
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.healthline.com/about/process).
- Anderson LPH, et al. (2016). The safety of melatonin in humans.
[https://link.springer.com/article/10.1007%2Fs40261-015-0368-5](https://link.springer.com/article/10.1007%2Fs40261-015-0368-5)
- Arendt J. (2019). Melatonin: Countering chaotic time cues.
<https://www.frontiersin.org/articles/10.3389/fendo.2019.00391/full>
- Boafo A, et al. (2019). Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician’s perspective.
<https://www.dovepress.com/could-long-term-administration-of-melatonin-to-prepubertal-children-af-peer-reviewed-fulltext-article-NSS>
- Erland LAE, et al. (2017). Melatonin natural health products and supplements: Presence of serotonin and significant variability of melatonin content.
<https://jcsm.aasm.org/doi/10.5664/jcsm.6462>
- FDA 101: Dietary supplements. (2015).
<https://www.fda.gov/consumers/consumer-updates/fda-101-dietary-supplements>
- Janjua I, et al. (2016). Sleep-related melatonin use in healthy children
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830653/>
- Melatonin for sleep problems. (2019).
<https://www.nhs.uk/medicines/melatonin/>
- Melatonin: What you need to know. (2019).
<https://www.nccih.nih.gov/health/melatonin-what-you-need-to-know>
- Melatonin. (2020).
<https://www.ncbi.nlm.nih.gov/books/NBK501863/>
- Savage RA, et al. (2020). Melatonin.
<https://www.ncbi.nlm.nih.gov/books/NBK534823/>
- Schroeck JL, et al. (2016). Review of safety and efficacy of sleep medicines in older adults.
<https://www.clinicaltherapeutics.com/article/S0149-2918(16)30733-0/fulltext>
- Sleep deprivation and deficiency. (n.d.).
<https://www.nhlbi.nih.gov/health-topics/sleep-deprivation-and-deficiency>
- Tordjman S, et al. (2017). Melatonin: Pharmacology, functions and therapeutic benefits.
<https://www.eurekaselect.com/148764/article>
- Zisapel N. (2018). New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.
<https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057895/>
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Medically reviewed by [Avi Varma, MD, MPH, AAHIVS, FAAFP](https://www.healthline.com/reviewers/avi-varma-md) — Written by [Jill Seladi-Schulman, Ph.D.](https://www.healthline.com/authors/jill-seladi-schulman) — Updated on September 27, 2024
### Read this next
- [Taking Melatonin: Can You Mix Melatonin and Alcohol?](https://www.healthline.com/health/melatonin-and-alcohol?utm_source=ReadNext)
Medically reviewed by [Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT](https://www.healthline.com/medical-team)
[Understand how melatonin and alcohol interact and how best to take melatonin to avoid negative side effects.](https://www.healthline.com/health/melatonin-and-alcohol?utm_source=ReadNext)
[READ MORE](https://www.healthline.com/health/melatonin-and-alcohol?utm_source=ReadNext)
- [Is Melatonin Addictive?](https://www.healthline.com/health/is-melatonin-addictive?utm_source=ReadNext)
Medically reviewed by [Alan Carter, Pharm.D.](https://www.healthline.com/medical-team)
[Melatonin is a naturally occurring hormone in the body that helps promote sleep. Because of its calming and sedating effects, it’s also called the…](https://www.healthline.com/health/is-melatonin-addictive?utm_source=ReadNext)
[READ MORE](https://www.healthline.com/health/is-melatonin-addictive?utm_source=ReadNext)
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| Readable Markdown | Melatonin can be an effective tool for improving sleep quality. However, it’s important to pay attention to dosage and consider potential risks and side effects.
[Melatonin](https://www.healthline.com/nutrition/melatonin-and-sleep) is a hormone that your body naturally produces. It plays a role in regulating your sleep-wake cycle.
There’s also a lab-made version of melatonin that’s available as an over-the-counter supplement. Some people use [melatonin supplements](https://www.healthline.com/nutrition/melatonin) to help with sleep problems like jet lag and insomnia.
In this article, we’ll explore how exactly melatonin works and whether it’s safe to take melatonin supplements every night.
Natural melatonin is predominantly made in your [pineal gland](https://www.healthline.com/health/pineal-gland-function), which is located in your brain. Light exposure inhibits the production of melatonin, but darkness stimulates it.
Melatonin levels in your brain begin to increase at dusk as the sun goes down and darkness falls. They reach their peak levels in the middle of the night and start decreasing as dawn gets closer.
Melatonin inhibits signals in the brain that promote wakefulness. This helps encourage sleep by making you feel tired or drowsy as you get closer to bedtime.
Because of melatonin’s sleep-promoting effects, melatonin supplements are used to treat a variety of sleep problems. These can include:
- [insomnia](https://www.healthline.com/health/insomnia)
- [jet lag](https://www.healthline.com/health/melatonin-for-jet-lag)
- [shift work sleep disorder](https://www.healthline.com/health/shift-work-sleep-disorder)
- [delayed sleep-wake phase disorder](https://www.healthline.com/health/sleep-deprivation/delayed-sleep-phase-syndrome)
- sleep problems in children with [autism](https://www.healthline.com/health/autism-alternative-treatments#melatonin) or [attention deficit hyperactivity disorder (ADHD)](https://www.healthline.com/health/ahd/sleep-problems)
The Food and Drug Administration (FDA) doesn’t regulate melatonin as a drug. Because of this, there’s limited information on the optimal, safe dosage of melatonin.
In fact, the doses of melatonin supplements that have been used in various scientific studies vary widely, from [0\.1 to 10 milligrams (mg)](https://www.ncbi.nlm.nih.gov/books/NBK534823/). One 2017 review defines a typical dose of melatonin to be between [1 and 5 mg](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/).
Melatonin typically takes [1 to 2 hours](https://www.nhs.uk/medicines/melatonin/) to work, so it’s often taken up to 2 hours before bedtime.
If you’re looking to try melatonin for the first time, it may be best to begin with a lower dose. Your doctor can help recommend a safe dose for you to start with.
Melatonin for children
Like melatonin for adults, there’s not much information on the optimal, safe dosage [for children](https://www.healthline.com/nutrition/melatonin-for-kids). Dosage may also vary depending on a child’s age. One [2016 review](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830653/) suggests the following age-based dosages 30 to 60 minutes before bedtime:
- 1 mg for infants
- 2\.5 to 3 mg for older children
- 5 mg for adolescents
Because there aren’t clear dosing guidelines regarding melatonin for children, be sure to speak to your child’s pediatrician before giving melatonin to your child.
Melatonin for older adults
The amount of melatonin your body produces decreases with age. Because of this, melatonin supplements may be helpful for older adults who are [having trouble falling asleep](https://www.healthline.com/health/sleep/sleep-disorders-in-the-elderly).
Researchers are still looking into the optimal melatonin dosage for older adults. One [2016 review](https://www.clinicaltherapeutics.com/article/S0149-2918\(16\)30733-0/fulltext) of sleep aids for older adults suggests a dosage of 1 to 2 mg of immediate-release melatonin 1 hour before bedtime.
What to know about dietary supplements and safety
The FDA classifies melatonin as a dietary supplement, meaning that it’s regulated less strictly than a regular drug. For dietary supplements, label claims and product safety don’t have to meet FDA approval before they’re marketed.
A [2017 study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263083/) of 31 different melatonin supplements found that the actual melatonin content of 71 percent of the products didn’t match the claim on the label. Additionally, 26 percent of products contained [serotonin](https://www.healthline.com/health/mental-health/serotonin), which can be potentially harmful even in small doses.
When shopping for melatonin supplements, look for products that are “USP verified.” [The United States Pharmacopeia (USP)](https://www.usp.org/verification-services/verified-mark) is an independent organization that ensures proper quality and dosing of dietary supplements.
You may be wondering what happens if you take a dose of melatonin and find that you still can’t fall asleep. Can you take another dose?
While taking an additional dose is [unlikely to cause harm](https://www.nhs.uk/medicines/melatonin/), it may increase your risk for experiencing unwanted side effects.
If you find that melatonin isn’t helping you fall asleep, stop using it. Your doctor may be able to suggest different medications or strategies to help you fall asleep.
[Some studies](https://pubmed.ncbi.nlm.nih.gov/26692007/) have indicated that long-term melatonin use in adults may cause mild side effects when compared to a placebo. Studies into the effects of long-term melatonin use in children remains limited.
Because melatonin levels naturally decrease at the beginning of puberty, there’s some concern that long-term melatonin use in children may delay puberty onset. However, [more research](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/) is needed.
There are some important things to know about melatonin, its interactions with other substances, and when it’s best to avoid it. Let’s take a closer look.
What medications and substances does melatonin interact with?
Melatonin may interact with several different types of medications, including:
- **Blood-thinning medications.** Taking melatonin with [blood-thinning medication](https://www.healthline.com/health/heart-disease/blood-thinners) may increase your risk for bleeding.
- **Epilepsy medications (anticonvulsants).** Melatonin may make [these medications](https://www.healthline.com/health/epilepsy/medications-list) less effective.
- **Immunosuppressants.** Melatonin can potentially interfere with [immunosuppressive drugs](https://www.healthline.com/health/immunosuppressant-drugs).
- **Diabetes medications.** Melatonin use can affect [blood sugar levels](https://www.healthline.com/health/type-2-diabetes/understanding-glucose-levels).
- **Blood pressure medications.** Blood pressure may get worse when melatonin is taken with [these medications](https://www.healthline.com/health/high-blood-pressure-hypertension-medication).
- **Contraceptive drugs.** [Birth control pills](https://www.healthline.com/health/birth-control/melatonin-and-birth-control) may increase the risk of side effects from melatonin.
Because melatonin supplements can make you tired and drowsy, avoid mixing them with:
- other sleep aids
- [central nervous system depressants](https://www.healthline.com/health/depression/cns-depression)
- [alcohol](https://www.healthline.com/health/melatonin-and-alcohol)
There’s limited research into the safety of using melatonin supplements [during pregnancy](https://www.healthline.com/health/pregnancy/melatonin-pregnancy). Also, while melatonin is a normal component of breast milk, there’s little research into the effects of taking melatonin supplements while breastfeeding.
Because of this, it’s best to avoid taking melatonin if you’re:
- pregnant
- planning to become pregnant
- breastfeeding
Additionally, it’s important to speak to your doctor before using melatonin if you have:
- an [autoimmune condition](https://www.healthline.com/health/autoimmune-disorders)
- [epilepsy](https://www.healthline.com/health/melatonin-and-epilepsy)
- [kidney disease](https://www.healthline.com/health/kidney-disease)
- [liver disease](https://www.healthline.com/health/liver-diseases)
- had a previous [allergic reaction](https://www.healthline.com/health/allergies/allergic-reaction) to melatonin
It’s a good idea to schedule an appointment with your doctor or healthcare professional if you notice that you:
- frequently have trouble falling asleep or staying asleep at night
- often feel drowsy or tired during the day
- have trouble performing your daily activities
Your doctor will work with you to discuss your [sleep routine](https://www.healthline.com/health/healthy-sleep/how-to-fix-sleep-schedule) and lifestyle habits. They may also ask you to keep a sleep diary to track the amount of sleep you’re getting over a period of time.
It’s also possible that your doctor will perform a physical exam and order blood tests. These can help them rule out a medical condition that may be causing your sleep issues.
Melatonin supplements can be used to help promote sleep. Because there’s currently no standard dosage associated with melatonin supplements, talk to your doctor about how much melatonin to take and when.
Melatonin is generally safe for short-term use, but studies on its long-term effects are limited. Its side effects are typically mild.
If you take melatonin and notice that it isn’t helping you fall asleep or causes unwanted side effects, stop taking it and speak with your doctor. They can help recommend other strategies to help you get a good night’s sleep. |
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