🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 98 (from laksa062)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa098.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.healthline.com/health/depression/combination-therapies\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.healthline.com/health/depression/combination-therapies\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.healthline.com\/health\/depression\/combination-therapies","crawl_time":1770556774,"first_indexed_time":1506115443,"http_code":200,"src_unparsed":"com,healthline!www,\/health\/depression\/combination-therapies s443","src_root_hash":"11478817528691466898","history_drop_reason":null,"meta_title":"Combination Medication Therapies for Depression","meta_descriptions":["New research is showing that combining antidepressants with medications for other mood disorders can be effective in helping people manage their depression."],"attrs_boilerpipe_text":"Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade.\nUntil recently, doctors prescribed an\nantidepressant\nmedication from only a single class of drugs, one medication at a time, called monotherapy.\nDoctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely.\nResearch from 2022\nnow suggests that taking a combination of a specific class of antidepressants that includes mianserin,\nmirtazapine\n, or\ntrazodone\nmay more effectively treat cases of acute to\nsevere depression\nand those who didn’t respond to monotherapy.\nAtypical antidepressants\nwork by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of:\ndopamine\nnorepinephrine\nserotonin\nBupropion\nOn its own,\nbupropion\neffectively treats\nMDD\n. But a doctor may also prescribe it with other medications for depression that is difficult to treat.\nMirtazapine may be an option for people experiencing loss of appetite and\ninsomnia\n. Its most common side effects are\nunintentional weight gain\nand sedation.\nHowever, in-depth studies on its use as a combination medication aren’t available.\nAntipsychotics\naripiprazole\nbrexpiprazole\nextended-release quetiapine\ncariprazine\nCurrent research also suggests a benefit of taking SSRIs and an antipsychotic for those with\nMDD with psychosis\n.\nA\n2024 review\nof 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis.\nunintentional\nweight gain\nchanges in muscle control or movement (\ntardive dyskinesia\n)\nmetabolic syndrome\nCarefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some\ndepression symptoms\n.\nL-triiodothyronine\nSome doctors use L-triiodothyronine (T3) in combination with SSRIs.\nResearch from 2021\nsuggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary.\nThe typical starting dose of T3 is\n25 micrograms (mcg)\ndaily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to\n50 mcg daily\n.\nStimulants\nDextroamphetamine (\nDexedrine\n) and\nmethylphenidate (Ritalin)\nare stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications.\nMany clinicians find that supplementing antidepressants with low doses of stimulants, such as\nmethylphenidate\n,\nmay help improve depression\nthat doesn’t respond well to treatment.\nHowever, not all clinical trials have shown benefits from this strategy.\nStimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination.\nMonotherapy’s success rates\nare low\ncompared to combination therapy with a certain type of antidepressant. Many researchers\nand doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression.\nMany doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective.\nIf the medication doesn’t work as desired after a trial period — usually about\n6 to 8 weeks\n— your doctor may change your medication or add one to see whether the combination helps.\nOptum Now is operated by RVO Health. By clicking on this link, we may receive a commission.\nLearn more.","attrs_markdown":"- Health Conditions\n  ### Health Conditions\n  [All](https:\/\/www.healthline.com\/directory\/topics)\n  \n  - [Breast Cancer](https:\/\/www.healthline.com\/breast-cancer)\n  - [Cancer Care](https:\/\/www.healthline.com\/cancer-care)\n  - [Caregiving for Alzheimer's Disease](https:\/\/www.healthline.com\/alzheimers-disease)\n  - [Chronic Kidney Disease](https:\/\/www.healthline.com\/ckd)\n  - [Chronic Obstructive Pulmonary Disease (COPD)](https:\/\/www.healthline.com\/copd)\n  - [Digestive Health](https:\/\/www.healthline.com\/digestive-health)\n  - [Eye Health](https:\/\/www.healthline.com\/eye-health)\n  - [Heart Health](https:\/\/www.healthline.com\/heart-health)\n  - [Menopause](https:\/\/www.healthline.com\/menopause)\n  - [Mental Health](https:\/\/www.healthline.com\/mental-health)\n  - [Migraine](https:\/\/www.healthline.com\/migraine)\n  - [Multiple Sclerosis (MS)](https:\/\/www.healthline.com\/multiple-sclerosis)\n  - [Parkinson’s Disease](https:\/\/www.healthline.com\/parkinsons-disease)\n  - [Psoriasis](https:\/\/www.healthline.com\/psoriasis)\n  - [Rheumatoid Arthritis (RA)](https:\/\/www.healthline.com\/rheumatoid-arthritis)\n  - [Sleep Health](https:\/\/www.healthline.com\/sleep)\n  - [Type 2 Diabetes](https:\/\/www.healthline.com\/type-2-diabetes)\n  - [Weight Management](https:\/\/www.healthline.com\/weight-management)\n  \n  ### Condition Spotlight\n  [All](https:\/\/www.healthline.com\/sponsored-topics)\n  \n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons-_controlling-ulcerative-colitis-236x236_360.png) Controlling Ulcerative Colitis](https:\/\/www.healthline.com\/program\/controlling-uc)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons_navigating-life-with-biopolar-236x236-1.png) Navigating Life with Bipolar Disorder](https:\/\/www.healthline.com\/program\/navigating-life-with-bipolar-disorder)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons-_mastering-your-geographic-atrophy-236x236_360.png) Mastering Geographic Atrophy](https:\/\/www.healthline.com\/program\/mastering-your-geographic-atrophy-care)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons_managing-type-2-diabetes-236x236-1.png) Managing Type 2 Diabetes](https:\/\/www.healthline.com\/program\/managing-type-2-diabetes-with-food-and-fitness)\n- Wellness\n  ### Wellness Topics\n  [All](https:\/\/www.healthline.com\/wellness)\n  \n  - [CBD](https:\/\/www.healthline.com\/cbd)\n  - [Fitness](https:\/\/www.healthline.com\/fitness)\n  - [Healthy Aging](https:\/\/www.healthline.com\/healthy-aging)\n  - [Hearing](https:\/\/www.healthline.com\/hearing-health)\n  - [Mental Well-Being](https:\/\/www.healthline.com\/mental-health)\n  - [Nutrition](https:\/\/www.healthline.com\/nutrition)\n  - [Parenthood](https:\/\/www.healthline.com\/parenthood)\n  - [Recipes](https:\/\/www.healthline.com\/recipes)\n  - [Sexual Health](https:\/\/www.healthline.com\/sexual-health)\n  - [Skin Care](https:\/\/www.healthline.com\/skincare)\n  - [Sleep Health](https:\/\/www.healthline.com\/sleep)\n  - [Vitamins and Supplements](https:\/\/www.healthline.com\/vitamins-supplements)\n  - 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[![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons-_understanding-inflammation-and-aging-236x236_360.png) Inflammation and Aging](https:\/\/www.healthline.com\/program\/understanding-inflammation-and-aging)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons-_cold-and-flu-236x236_360.png) Cold & Flu Season Survival Guide](https:\/\/www.healthline.com\/program\/cold-flu-survival-guide)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/navigation-icons_shes-good-for-real-236x236-1.png) She’s Good for Real](https:\/\/www.healthline.com\/program\/shes-good-for-real)\n- Tools\n  ### Featured\n  - [Video Series](https:\/\/www.healthline.com\/video)\n  - [Pill Identifier](https:\/\/www.healthline.com\/pill-identifier)\n  - [FindCare](https:\/\/care.healthline.com\/find-care)\n  - [Drugs A-Z](https:\/\/www.healthline.com\/drugs)\n  - [Medicare Plans by State](https:\/\/www.healthline.com\/about\/health-medicare-state-coverage)\n  \n  ### Lessons\n  [All](https:\/\/learn.healthline.com\/)\n  \n  - [Crohn’s and Ulcerative Colitis Essentials](https:\/\/www.healthline.com\/app\/inflammatory-bowel-disease?utm_source=lessonshome)\n  - [Diabetes Nutrition](https:\/\/www.healthline.com\/app\/type-2-diabetes?utm_source=lessonshome)\n  - [High Cholesterol](https:\/\/www.healthline.com\/app\/high-cholesterol?utm_source=lessonshome)\n  - [Taming Inflammation in Psoriasis](https:\/\/www.healthline.com\/app\/pso-inflammation?utm_source=lessonshome)\n  - [Taming Inflammation in Psoriatic Arthritis](https:\/\/www.healthline.com\/app\/psa-inflammation?utm_source=lessonshome)\n  \n  ### Newsletters\n  [All](https:\/\/www.healthline.com\/newsletter-signup)\n  \n  - [Anxiety and Depression](https:\/\/www.healthline.com\/newsletter-signup\/anxiety-and-depression)\n  - [Digestive Health](https:\/\/www.healthline.com\/newsletter-signup\/ibd)\n  - [Heart Health](https:\/\/www.healthline.com\/newsletter-signup\/heart-health)\n  - [Migraine](https:\/\/www.healthline.com\/newsletter-signup\/migraine)\n  - [Nutrition Edition](https:\/\/www.healthline.com\/newsletter-signup\/nutrition)\n  - [Type 2 Diabetes](https:\/\/www.healthline.com\/newsletter-signup\/type-2-diabetes)\n  - [Wellness Wire](https:\/\/www.healthline.com\/newsletter-signup\/wellness-wire)\n  \n  ### Lifestyle Quizzes\n  - [Find a Diet](https:\/\/activation.healthline.com\/assessment\/assessment\/diets\/prompt\/1?v=1&tc=120226&subid=hl_dietfinder_1_)\n  - [Find Healthy Snacks](https:\/\/activation.healthline.com\/assessment\/assessment\/pregnancy-snacks\/prompt\/1?v=1)\n  - [Weight Management](https:\/\/www.healthline.com\/nutrition\/weight-management-quiz)\n  - [How Well Do You Sleep?](https:\/\/www.healthline.com\/health\/healthy-sleep\/quiz-how-well-do-you-sleep#1)\n  - [Are You a Workaholic?](https:\/\/www.healthline.com\/health\/mental-health\/quiz-are-you-a-workaholic#quiz-are-you-a-workaholic)\n- Featured\n  ### Health News\n  [All](https:\/\/www.healthline.com\/health-news)\n  \n  - [Medicare 2026 Changes](https:\/\/www.healthline.com\/health-news\/medicare-open-enrollment-2026-key-changes)\n  - [Can 6-6-6 Walking Workout Help You Lose Weight?](https:\/\/www.healthline.com\/health-news\/666-walking-trend-weight-loss)\n  - [This Couple Lost 118 Pounds Together Without Medication](https:\/\/www.healthline.com\/health-news\/married-couple-loses-119-pounds-together-without-meds)\n  - [5 Science-Backed Ways to Live a Longer Life](https:\/\/www.healthline.com\/health-news\/healthy-ways-to-improve-longevity)\n  - [Morning Coffee May Help You Live Longer](https:\/\/www.healthline.com\/health-news\/morning-coffee-heart-health-benefits)\n  \n  ### This Just In\n  - [5 Tips for a Healthy Lifestyle](https:\/\/www.healthline.com\/health\/fitness-nutrition\/healthy-lifestyle-benefits)\n  - [How to Disinfect Your House After the Flu](https:\/\/www.healthline.com\/health\/flu\/how-to-disinfect-house-after-flu)\n  - [Best Vegan and Plant-Based Meal Delivery for 2025](https:\/\/www.healthline.com\/nutrition\/plant-based-meal-delivery)\n  - [Does Medicare Cover Pneumonia Shots?](https:\/\/www.healthline.com\/health\/medicare\/does-medicare-cover-pneumonia-shots)\n  - [Chromosomes, Genetics, and Your Health](https:\/\/www.healthline.com\/health\/chromosomes-and-genetics)\n  \n  ### Top Reads\n  - [Best Multivitamins for Women](https:\/\/www.healthline.com\/nutrition\/multivitamins-womens-health)\n  - [Best Multivitamins for Men](https:\/\/www.healthline.com\/nutrition\/best-multivitamins-for-men)\n  - [Best Online Therapy Services](https:\/\/www.healthline.com\/health\/our-top-10-online-therapy-picks)\n  - [Online Therapy That Takes Insurance](https:\/\/www.healthline.com\/health\/mental-health\/online-therapy-that-takes-insurance)\n  - [Buy Ozempic Online](https:\/\/www.healthline.com\/nutrition\/buy-ozempic-online)\n  - [Mounjaro Overview](https:\/\/www.healthline.com\/health\/drugs\/mounjaro)\n  \n  ### Video Series\n  - [Youth in Focus](https:\/\/www.healthline.com\/health\/video\/youth-in-focus)\n  - [Healthy Harvest](https:\/\/www.healthline.com\/health\/nutrition\/video\/healthy-harvest#1)\n  - [Through an Artist's Eye](https:\/\/www.healthline.com\/health\/breast-cancer\/metastatic-breast-cancer-artist-eye)\n  - [Future of Health](https:\/\/www.healthline.com\/health\/video\/future-of-health)\n- Connect\n  ### Find Your Bezzy Community\n  Bezzy communities provide meaningful connections with others living with chronic conditions. Join Bezzy on the web or mobile app.\n  \n  [All](https:\/\/www.bezzy.com\/?utm_source=healthline&utm_medium=nav-bar-connections)\n  \n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2022\/01\/Bezzy-Breast-Cancer.png) Breast Cancer](https:\/\/www.bezzybc.com\/lp\/2\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2022\/01\/Bezzy-Multiple-Sclerosis.png) Multiple Sclerosis](https:\/\/www.bezzyms.com\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/11\/Bezzy-DEP-Icon-Circle.png) Depression](https:\/\/www.bezzydepression.com\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2025\/01\/Bezzy-MIG-Icon-Circle.png) Migraine](https:\/\/www.bezzymigraine.com\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2024\/12\/Bezzy-T2D-Icon-Circle.png) Type 2 Diabetes](https:\/\/www.bezzyt2d.com\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  - [![](https:\/\/media.post.rvohealth.io\/wp-content\/uploads\/2022\/04\/Bezzy-PsO.png) Psoriasis](https:\/\/www.bezzypsoriasis.com\/?utm_source=healthline&utm_medium=hl-nav-bar-connections)\n  \n  ### Follow us on social media\n  Can't get enough? Connect with us for all things health.\n\nSubscribe\n\n[Anxiety and Depression](https:\/\/www.healthline.com\/anxiety-and-depression)\n\n- [Anxiety Treatment](https:\/\/www.healthline.com\/anxiety-and-depression\/anxiety-treatment)\n- [Depression Treatment](https:\/\/www.healthline.com\/anxiety-and-depression\/depression-treatment)\n- [Crisis Support](https:\/\/www.healthline.com\/anxiety-and-depression\/crisis-support)\n- [Navigating Therapy](https:\/\/www.healthline.com\/anxiety-and-depression\/therapy)\n- [Symptoms](https:\/\/www.healthline.com\/anxiety-and-depression\/symptom-management)\n- [Better Sleep](https:\/\/www.healthline.com\/anxiety-and-depression\/sleep-resources)\n- [Nutrition & Supplements](https:\/\/www.healthline.com\/anxiety-and-depression\/nutrition-supplements)\n- [Relationships](https:\/\/www.healthline.com\/anxiety-and-depression\/relationships)\n- [Emotional Well-Being](https:\/\/www.healthline.com\/anxiety-and-depression\/emotional-well-being)\n- [Physical Activity & Exercises](https:\/\/www.healthline.com\/anxiety-and-depression\/physical-activity-exercises)\n- [Resources for Doctors' Visits](https:\/\/www.healthline.com\/anxiety-and-depression\/doctor-guide)\n- [Comorbidities](https:\/\/www.healthline.com\/anxiety-and-depression\/comorbidities)\n\n# Combination Medication Therapies for Depression\n![](https:\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2022\/05\/Yalda-Safai-500x500-Bio1.png?w=105&h=105)\n\n[Medically reviewed]() by [Yalda Safai, MD, MPH]() — Written by [Kimberly Holland]() and Dana Robinson —  [Updated on November 15, 2024]()\n\n- [Role of medications](https:\/\/www.healthline.com\/health\/depression\/combination-therapies#role-of-medications)\n- [Atypical antidepressants](https:\/\/www.healthline.com\/health\/depression\/combination-therapies#atypical-antidepressants)\n- [Takeaway](https:\/\/www.healthline.com\/health\/depression\/combination-therapies#takeaway)\n\n### Key Takeaways\n- If you have major depressive disorder (MDD) and your symptoms don’t respond to a single antidepressant, combining specific antidepressants may be more effective.\n- Atypical antidepressants, such as bupropion, can be used alone or with SSRIs or SNRIs to treat MDD. Antipsychotics may also be effective when other treatments don’t work or for MDD with psychosis.\n- If a single antidepressant isn’t working after 6 to 8 weeks, a doctor may adjust the medication or add another to the regimen to improve effectiveness. Only a healthcare professional can advise if it’s safe to combine prescription medications.\n\nIf you have [major depressive disorder (MDD)](https:\/\/www.healthline.com\/health\/clinical-depression), you may be taking an antidepressant.\n\nCombination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade.\n\n## [The role of medications]()\nUntil recently, doctors prescribed an [antidepressant](https:\/\/www.healthline.com\/health\/depression\/antidepressants-pros-and-cons) medication from only a single class of drugs, one medication at a time, called monotherapy.\n\nDoctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely.\n\n[Research from 2022](https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2789300) now suggests that taking a combination of a specific class of antidepressants that includes mianserin, [mirtazapine](https:\/\/www.medicalnewstoday.com\/articles\/mirtazapine-oral-tablet), or [trazodone](https:\/\/www.healthline.com\/health\/drugs\/trazodone-oral-tablet) may more effectively treat cases of acute to [severe depression](https:\/\/www.healthline.com\/health\/depression\/crippling-depression) and those who didn’t respond to monotherapy.\n\n## [Atypical antidepressants]()\n[Atypical antidepressants](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538182\/) work by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of:\n\n- [dopamine](https:\/\/www.healthline.com\/health\/dopamine-effects)\n- norepinephrine\n- [serotonin](https:\/\/www.healthline.com\/health\/mental-health\/serotonin)\n### Bupropion\nOn its own, [bupropion](https:\/\/www.healthline.com\/health\/bupropion-oral-tablet) effectively treats [MDD](https:\/\/www.healthline.com\/health\/clinical-depression). But a doctor may also prescribe it with other medications for depression that is difficult to treat.\n\nBupropion is one of the most commonly used combination therapy medications. Medical professionals often use it with [selective serotonin reuptake inhibitors (SSRIs)](https:\/\/www.healthline.com\/health\/depression\/selective-serotonin-reuptake-inhibitors-ssris) and [serotonin-norepinephrine reuptake inhibitors (SNRIs)](https:\/\/www.healthline.com\/health\/depression\/serotonin-norepinephrine-reuptake-inhibitors-snris).\n\nPeople who’ve experienced severe [side effects](https:\/\/www.healthline.com\/health\/antidepressant-side-effects) from other [antidepressant medications](https:\/\/www.healthline.com\/health\/depression\/medication-list) generally tolerate bupropion. It may also relieve some of the [sexual side effects](https:\/\/www.healthline.com\/health\/erectile-dysfunction\/antidepressant-sexual-side-effects) associated with some SSRIs and SNRIs.\n\nMirtazapine may be an option for people experiencing loss of appetite and [insomnia](https:\/\/www.healthline.com\/health\/types-of-insomnia). Its most common side effects are [unintentional weight gain](https:\/\/www.healthline.com\/health\/antidepressants-that-cause-weight-gain) and sedation.\n\nHowever, in-depth studies on its use as a combination medication aren’t available.\n\n### Antipsychotics\n[Research](https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20230025) published in 2023 suggests atypical [antipsychotics](https:\/\/www.healthline.com\/health\/mental-health\/what-are-antipsychotics) may effectively treat [treatment-resistant depression](https:\/\/www.healthline.com\/health\/treatment-resistant-depression). Food and Drug Administration (FDA) approved antipsychotics include:\n\n- [aripiprazole](https:\/\/www.healthline.com\/health\/aripiprazole-oral-tablet)\n- brexpiprazole\n- extended-release quetiapine\n- [cariprazine](https:\/\/www.healthline.com\/health\/drugs\/vraylar)\n\nCurrent research also suggests a benefit of taking SSRIs and an antipsychotic for those with [MDD with psychosis](https:\/\/www.healthline.com\/health\/depression\/psychotic-depression).\n\nA [2024 review](https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366\\(24\\)00006-3\/abstract) of 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis.\n\n[Antipsychotics](https:\/\/www.healthline.com\/health\/mental-health\/what-are-antipsychotics), however, may have some [side effects](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519503\/):\n\n- unintentional [weight gain](https:\/\/www.healthline.com\/health\/mental-health\/weight-gain-on-antipsychotics)\n- changes in muscle control or movement ([tardive dyskinesia](https:\/\/www.healthline.com\/health\/tardive-dyskinesia))\n- [metabolic syndrome](https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8001502\/)\n\nCarefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some [depression symptoms](https:\/\/www.healthline.com\/health\/video\/5-symptoms-depression).\n\n### L-triiodothyronine\nSome doctors use L-triiodothyronine (T3) in combination with SSRIs.\n\n[Research from 2021](https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2468171720300144) suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary.\n\nThe typical starting dose of T3 is [25 micrograms (mcg)](https:\/\/labeling.pfizer.com\/showlabeling.aspx?id=703) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to [50 mcg daily](https:\/\/www.psychiatrist.com\/jcp\/thyroid-hormone-use-in-mood-disorders\/).\n\n### Stimulants\nDextroamphetamine ([Dexedrine](https:\/\/www.healthline.com\/health\/drugs\/dextroamphetamine-oral-tablet)) and [methylphenidate (Ritalin)](https:\/\/www.medicalnewstoday.com\/articles\/drugs-ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications.\n\nMany clinicians find that supplementing antidepressants with low doses of stimulants, such as [methylphenidate](https:\/\/www.healthline.com\/health\/drugs\/methylphenidate-oral-tablet), [may help improve depression](https:\/\/link.springer.com\/article\/10.1007\/s40501-023-00307-4) that doesn’t respond well to treatment.\n\nHowever, not all clinical trials have shown benefits from this strategy.\n\nStimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination.\n\n## [The takeaway]()\nMonotherapy’s success rates [are low](https:\/\/www.aafp.org\/pubs\/afp\/issues\/2022\/1000\/poems-antidepressant-therapy.html) compared to combination therapy with a certain type of antidepressant. Many researchers and doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression.\n\nMany doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective.\n\nIf the medication doesn’t work as desired after a trial period — usually about [6 to 8 weeks](https:\/\/www.healthquality.va.gov\/guidelines\/MH\/mdd\/) — your doctor may change your medication or add one to see whether the combination helps.\n\n**»MORE:**[Get a refill for your medication in as little as 15 minutes with Optum Now Online Care.](https:\/\/now.optum.com\/online-care\/prescription-refill?utm_source=healthline&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-rxrefill&utm_campaign=hl-article-oc-on-backlink)\n\nOptum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https:\/\/www.healthline.com\/about\/brand-and-product-vetting)\n\n### How we reviewed this article:\nSources\n\nHistory\n\nHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https:\/\/www.healthline.com\/about\/process).\n\n- Carli M, et al. (2021). Atypical antipsychotics and metabolic syndrome: From molecular mechanisms to clinical differences.  \n  <https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8001502\/>\n- Chokhawala K, et al. (2023). Antipsychotic medications.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519503\/>\n- Clinical practice guideline for the treatment of depression across three age cohorts. (2024).  \n  <https:\/\/www.apa.org\/depression-guideline>\n- Cytomel (liothyronine sodium) tablets, for oral use. (2019).  \n  <https:\/\/labeling.pfizer.com\/showlabeling.aspx?id=703>\n- Hajnas N, et al. (2021). T3 augmentation in major depressive disorder: Sex and age differences.  \n  <https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2468171720300144>\n- Henssler J, et al. (2022). Combining antidepressants vs antidepressant monotherapy for treatment of patients with acute depression.  \n  <https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2789300>\n- Janela D, et al. (2023). Psychostimulant augmentation of antidepressant therapy in depression: A systematic review and meta-analysis.  \n  <https:\/\/link.springer.com\/article\/10.1007\/s40501-023-00307-4>\n- Jha MK, et al. (2023). Pharmacotherapies for treatment-resistant depression: How antipsychotics fit the rapidly evolving therapeutic landscape.  \n  <https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20230025>\n- Oliva V, et al. (2024). Pharmacological treatments for psychotic depression: A systematic review and network meta-analysis.  \n  <https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(24)00006-3\/abstract>\n- Sheffler ZM, et al. (2023). Antidepressants.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538182\/>\n- Singh B, et al. (2022). Thyroid hormone use in mood disorders: Revisiting the evidence.  \n  <https:\/\/www.psychiatrist.com\/jcp\/thyroid-hormone-use-in-mood-disorders\/>\n- Slawson DC. (2022). Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression.  \n  <https:\/\/www.aafp.org\/pubs\/afp\/issues\/2022\/1000\/poems-antidepressant-therapy.html>\n- VA\/DoD clinical practice guideline for the management of major depressive disorder. (2016).  \n  <https:\/\/www.healthquality.va.gov\/guidelines\/MH\/mdd\/VADoDMDDCPGFINAL82916.pdf>\n\nShare this article\n\n![](https:\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2022\/05\/Yalda-Safai-500x500-Bio1.png?w=105&h=105)\n\n[Medically reviewed]() by [Yalda Safai, MD, MPH]() — Written by [Kimberly Holland]() and Dana Robinson —  [Updated on November 15, 2024]()\n\n## related stories\n- [Can You Overdose on Antidepressants?](https:\/\/www.healthline.com\/health\/can-you-overdose-on-antidepressants?utm_source=ReadNext)\n- [How to Manage Treatment-Resistant Depression](https:\/\/www.healthline.com\/health\/treatment-resistant-depression?utm_source=ReadNext)\n- [Switching Antidepressants: Charts, Strategies, and More](https:\/\/www.healthline.com\/health\/mdd\/switching-antidepressants?utm_source=ReadNext)\n- [How to Deal with the Sexual Side Effects of Depression Treatments](https:\/\/www.healthline.com\/health\/depression\/sexual-side-effects-depression-treatments?utm_source=ReadNext)\n- [What Are the Benefits of Getting Off Antidepressants?](https:\/\/www.healthline.com\/health\/depression\/benefits-of-getting-off-antidepressants?utm_source=ReadNext)\n\n### Read this next\n- [Can You Overdose on Antidepressants?](https:\/\/www.healthline.com\/health\/can-you-overdose-on-antidepressants?utm_source=ReadNext)\n  \n  Medically reviewed by [Dena Westphalen, PharmD](https:\/\/www.healthline.com\/medical-team)\n  \n  [Antidepressants are used to treat symptoms of depression, chronic pain, and other mood disorders. But can you accidentally overdose? Are they safe?](https:\/\/www.healthline.com\/health\/can-you-overdose-on-antidepressants?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/can-you-overdose-on-antidepressants?utm_source=ReadNext)\n- [How to Manage Treatment-Resistant Depression](https:\/\/www.healthline.com\/health\/treatment-resistant-depression?utm_source=ReadNext)\n  \n  [Treatment-resistant depression refers to depression that doesn’t respond to common treatments. Despite the name, there are still treatments that can…](https:\/\/www.healthline.com\/health\/treatment-resistant-depression?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/treatment-resistant-depression?utm_source=ReadNext)\n- [Switching Antidepressants: Charts, Strategies, and More](https:\/\/www.healthline.com\/health\/mdd\/switching-antidepressants?utm_source=ReadNext)\n  \n  [Switching antidepressants needs to be done carefully and with the help of your doctor. Learn more here.](https:\/\/www.healthline.com\/health\/mdd\/switching-antidepressants?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/mdd\/switching-antidepressants?utm_source=ReadNext)\n- [How to Deal with the Sexual Side Effects of Depression Treatments](https:\/\/www.healthline.com\/health\/depression\/sexual-side-effects-depression-treatments?utm_source=ReadNext)\n  \n  Medically reviewed by [Jennifer Litner, PhD, LMFT, CST](https:\/\/www.healthline.com\/medical-team)\n  \n  [Treatments for depression can impact your sexual function. Find out which treatments are most and least likely to have these effects and solutions you…](https:\/\/www.healthline.com\/health\/depression\/sexual-side-effects-depression-treatments?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/depression\/sexual-side-effects-depression-treatments?utm_source=ReadNext)\n- [What Are the Benefits of Getting Off Antidepressants?](https:\/\/www.healthline.com\/health\/depression\/benefits-of-getting-off-antidepressants?utm_source=ReadNext)\n  \n  Medically reviewed by [Nicole Washington, DO, MPH](https:\/\/www.healthline.com\/medical-team)\n  \n  [Stopping antidepressants should be done with guidance from your doctor but here's how you may benefit from stopping your antidepressants.](https:\/\/www.healthline.com\/health\/depression\/benefits-of-getting-off-antidepressants?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/depression\/benefits-of-getting-off-antidepressants?utm_source=ReadNext)\n- [The Power of Glimmers and Joy Lists](https:\/\/www.healthline.com\/health\/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext)\n  \n  Medically reviewed by [Jennifer Litner, PhD, LMFT, CST](https:\/\/www.healthline.com\/medical-team)\n  \n  [Looking for an easy and effective self-care tool? Glimmers and joy lists will make you smile.](https:\/\/www.healthline.com\/health\/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext)\n- [How Long Does Wellbutrin Take to Work? And Other Reddit Questions Answered](https:\/\/www.healthline.com\/health\/drugs\/wellbutrin-reddit?utm_source=ReadNext)\n  \n  [Get answers to common Reddit questions about starting Wellbutrin such as: How long does it take to start working? Can you make it work faster? And…](https:\/\/www.healthline.com\/health\/drugs\/wellbutrin-reddit?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/drugs\/wellbutrin-reddit?utm_source=ReadNext)\n- [Antidepressant Side Effects Like Weight, Blood Pressure Changes Vary by Drug](https:\/\/www.healthline.com\/health-news\/antidepressant-side-effects-vary-widely-by-drug?utm_source=ReadNext)\n  \n  [A large new study found that the side effects of antidepressants vary significantly by drug. Some medications resulted in weight loss, while others…](https:\/\/www.healthline.com\/health-news\/antidepressant-side-effects-vary-widely-by-drug?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health-news\/antidepressant-side-effects-vary-widely-by-drug?utm_source=ReadNext)\n- [Depression vs. Seasonal Affective Disorder (SAD): Comparison and When to Contact a Doctor](https:\/\/www.healthline.com\/health\/depression-vs-seasonal?utm_source=ReadNext)\n  \n  [Depression causes persistent feelings of sadness. Seasonal affective disorder (SAD) is when depression symptoms occur in winter months. Learn more…](https:\/\/www.healthline.com\/health\/depression-vs-seasonal?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/depression-vs-seasonal?utm_source=ReadNext)\n- [What Is the Geriatric Depression Scale?](https:\/\/www.healthline.com\/health\/geriatric-depression-scale?utm_source=ReadNext)\n  \n  [The geriatric depression scale is a screening tool that can help identify depression in older adults. Learn about the different versions, their uses…](https:\/\/www.healthline.com\/health\/geriatric-depression-scale?utm_source=ReadNext)\n  \n  [READ MORE](https:\/\/www.healthline.com\/health\/geriatric-depression-scale?utm_source=ReadNext)\n\n© 2026 Healthline Media LLC. All rights reserved. Healthline Media is an RVO Health Company. Our website services, content, and products are for informational purposes only. Healthline Media does not provide medical advice, diagnosis, or treatment. [See additional information](https:\/\/www.healthline.com\/additional-information).\n\n- [About Us](https:\/\/www.healthline.com\/about)\n- [Contact Us](https:\/\/www.healthline.com\/about\/contact-us)\n- [Privacy Policy](https:\/\/www.healthline.com\/privacy-policy)\n- [Privacy Settings](https:\/\/www.healthline.com\/privacy-settings)\n- [Advertising Policy](https:\/\/www.healthline.com\/advertising-policy)\n- [Health Topics](https:\/\/www.healthline.com\/directory\/topics)\n\n- [Sitemap](https:\/\/www.healthline.com\/sitemap)\n- [Medical Affairs](https:\/\/www.healthline.com\/medical-team)\n- [Content Integrity](https:\/\/www.healthline.com\/about\/content-integrity)\n- [Newsletters](https:\/\/www.healthline.com\/newsletter-signup)\n- © 2026 Healthline Media LLC. All rights reserved. Healthline Media is an RVO Health Company. Our website services, content, and products are for informational purposes only. Healthline Media does not provide medical advice, diagnosis, or treatment. [See additional information](https:\/\/www.healthline.com\/additional-information).\n\n© 2026 Healthline Media LLC. All rights reserved. Healthline Media is an RVO Health Company. Our website services, content, and products are for informational purposes only. Healthline Media does not provide medical advice, diagnosis, or treatment. [See additional information](https:\/\/www.healthline.com\/additional-information).\n\n[About](https:\/\/www.healthlinemedia.com\/?utm_source=healthline.com&utm_medium=site&utm_campaign=footer&utm_content=about)[Careers](https:\/\/rvohealth.com\/careers)[Advertise with us](https:\/\/www.healthlinemedia.com\/advertise?utm_source=healthline.com&utm_medium=site&utm_campaign=footer&utm_content=advertise)\n\nOUR BRANDS\n\n[Healthline](https:\/\/www.healthline.com\/)[Medical News Today](https:\/\/www.medicalnewstoday.com\/)[Greatist](https:\/\/greatist.com\/)[Psych Central](https:\/\/psychcentral.com\/)[Bezzy](https:\/\/bezzy.com\/)\n\n![](http:\/\/b.scorecardresearch.com\/p?c1=2&c2=38584006&cv=3.9&cj=1&comscorekw=main)","attrs_readable_markdown":"Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade.\n\nUntil recently, doctors prescribed an [antidepressant](https:\/\/www.healthline.com\/health\/depression\/antidepressants-pros-and-cons) medication from only a single class of drugs, one medication at a time, called monotherapy.\n\nDoctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely.\n\n[Research from 2022](https:\/\/jamanetwork.com\/journals\/jamapsychiatry\/fullarticle\/2789300) now suggests that taking a combination of a specific class of antidepressants that includes mianserin, [mirtazapine](https:\/\/www.medicalnewstoday.com\/articles\/mirtazapine-oral-tablet), or [trazodone](https:\/\/www.healthline.com\/health\/drugs\/trazodone-oral-tablet) may more effectively treat cases of acute to [severe depression](https:\/\/www.healthline.com\/health\/depression\/crippling-depression) and those who didn’t respond to monotherapy.\n\n[Atypical antidepressants](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538182\/) work by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of:\n\n- [dopamine](https:\/\/www.healthline.com\/health\/dopamine-effects)\n- norepinephrine\n- [serotonin](https:\/\/www.healthline.com\/health\/mental-health\/serotonin)\n\nBupropion\n\nOn its own, [bupropion](https:\/\/www.healthline.com\/health\/bupropion-oral-tablet) effectively treats [MDD](https:\/\/www.healthline.com\/health\/clinical-depression). But a doctor may also prescribe it with other medications for depression that is difficult to treat.\n\nMirtazapine may be an option for people experiencing loss of appetite and [insomnia](https:\/\/www.healthline.com\/health\/types-of-insomnia). Its most common side effects are [unintentional weight gain](https:\/\/www.healthline.com\/health\/antidepressants-that-cause-weight-gain) and sedation.\n\nHowever, in-depth studies on its use as a combination medication aren’t available.\n\nAntipsychotics\n\n- [aripiprazole](https:\/\/www.healthline.com\/health\/aripiprazole-oral-tablet)\n- brexpiprazole\n- extended-release quetiapine\n- [cariprazine](https:\/\/www.healthline.com\/health\/drugs\/vraylar)\n\nCurrent research also suggests a benefit of taking SSRIs and an antipsychotic for those with [MDD with psychosis](https:\/\/www.healthline.com\/health\/depression\/psychotic-depression).\n\nA [2024 review](https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366\\(24\\)00006-3\/abstract) of 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis.\n\n- unintentional [weight gain](https:\/\/www.healthline.com\/health\/mental-health\/weight-gain-on-antipsychotics)\n- changes in muscle control or movement ([tardive dyskinesia](https:\/\/www.healthline.com\/health\/tardive-dyskinesia))\n- [metabolic syndrome](https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8001502\/)\n\nCarefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some [depression symptoms](https:\/\/www.healthline.com\/health\/video\/5-symptoms-depression).\n\nL-triiodothyronine\n\nSome doctors use L-triiodothyronine (T3) in combination with SSRIs.\n\n[Research from 2021](https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S2468171720300144) suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary.\n\nThe typical starting dose of T3 is [25 micrograms (mcg)](https:\/\/labeling.pfizer.com\/showlabeling.aspx?id=703) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to [50 mcg daily](https:\/\/www.psychiatrist.com\/jcp\/thyroid-hormone-use-in-mood-disorders\/).\n\nStimulants\n\nDextroamphetamine ([Dexedrine](https:\/\/www.healthline.com\/health\/drugs\/dextroamphetamine-oral-tablet)) and [methylphenidate (Ritalin)](https:\/\/www.medicalnewstoday.com\/articles\/drugs-ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications.\n\nMany clinicians find that supplementing antidepressants with low doses of stimulants, such as [methylphenidate](https:\/\/www.healthline.com\/health\/drugs\/methylphenidate-oral-tablet), [may help improve depression](https:\/\/link.springer.com\/article\/10.1007\/s40501-023-00307-4) that doesn’t respond well to treatment.\n\nHowever, not all clinical trials have shown benefits from this strategy.\n\nStimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination.\n\nMonotherapy’s success rates [are low](https:\/\/www.aafp.org\/pubs\/afp\/issues\/2022\/1000\/poems-antidepressant-therapy.html) compared to combination therapy with a certain type of antidepressant. Many researchers and doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression.\n\nMany doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective.\n\nIf the medication doesn’t work as desired after a trial period — usually about [6 to 8 weeks](https:\/\/www.healthquality.va.gov\/guidelines\/MH\/mdd\/) — your doctor may change your medication or add one to see whether the combination helps.\n\nOptum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https:\/\/www.healthline.com\/about\/brand-and-product-vetting)","meta_canonical":null}

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Boilerpipe Text	Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade. Until recently, doctors prescribed an antidepressant medication from only a single class of drugs, one medication at a time, called monotherapy. Doctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely. Research from 2022 now suggests that taking a combination of a specific class of antidepressants that includes mianserin, mirtazapine , or trazodone may more effectively treat cases of acute to severe depression and those who didn’t respond to monotherapy. Atypical antidepressants work by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of: dopamine norepinephrine serotonin Bupropion On its own, bupropion effectively treats MDD . But a doctor may also prescribe it with other medications for depression that is difficult to treat. Mirtazapine may be an option for people experiencing loss of appetite and insomnia . Its most common side effects are unintentional weight gain and sedation. However, in-depth studies on its use as a combination medication aren’t available. Antipsychotics aripiprazole brexpiprazole extended-release quetiapine cariprazine Current research also suggests a benefit of taking SSRIs and an antipsychotic for those with MDD with psychosis . A 2024 review of 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis. unintentional weight gain changes in muscle control or movement ( tardive dyskinesia ) metabolic syndrome Carefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some depression symptoms . L-triiodothyronine Some doctors use L-triiodothyronine (T3) in combination with SSRIs. Research from 2021 suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary. The typical starting dose of T3 is 25 micrograms (mcg) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to 50 mcg daily . Stimulants Dextroamphetamine ( Dexedrine ) and methylphenidate (Ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications. Many clinicians find that supplementing antidepressants with low doses of stimulants, such as methylphenidate , may help improve depression that doesn’t respond well to treatment. However, not all clinical trials have shown benefits from this strategy. Stimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination. Monotherapy’s success rates are low compared to combination therapy with a certain type of antidepressant. Many researchers and doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression. Many doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective. If the medication doesn’t work as desired after a trial period — usually about 6 to 8 weeks — your doctor may change your medication or add one to see whether the combination helps. Optum Now is operated by RVO Health. By clicking on this link, we may receive a commission. Learn more.
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Subscribe [Anxiety and Depression](https://www.healthline.com/anxiety-and-depression) - [Anxiety Treatment](https://www.healthline.com/anxiety-and-depression/anxiety-treatment) - [Depression Treatment](https://www.healthline.com/anxiety-and-depression/depression-treatment) - [Crisis Support](https://www.healthline.com/anxiety-and-depression/crisis-support) - [Navigating Therapy](https://www.healthline.com/anxiety-and-depression/therapy) - [Symptoms](https://www.healthline.com/anxiety-and-depression/symptom-management) - [Better Sleep](https://www.healthline.com/anxiety-and-depression/sleep-resources) - [Nutrition & Supplements](https://www.healthline.com/anxiety-and-depression/nutrition-supplements) - [Relationships](https://www.healthline.com/anxiety-and-depression/relationships) - [Emotional Well-Being](https://www.healthline.com/anxiety-and-depression/emotional-well-being) - [Physical Activity & Exercises](https://www.healthline.com/anxiety-and-depression/physical-activity-exercises) - [Resources for Doctors' Visits](https://www.healthline.com/anxiety-and-depression/doctor-guide) - [Comorbidities](https://www.healthline.com/anxiety-and-depression/comorbidities) # Combination Medication Therapies for Depression ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2022/05/Yalda-Safai-500x500-Bio1.png?w=105&h=105) [Medically reviewed]() by [Yalda Safai, MD, MPH]() — Written by [Kimberly Holland]() and Dana Robinson — [Updated on November 15, 2024]() - [Role of medications](https://www.healthline.com/health/depression/combination-therapies#role-of-medications) - [Atypical antidepressants](https://www.healthline.com/health/depression/combination-therapies#atypical-antidepressants) - [Takeaway](https://www.healthline.com/health/depression/combination-therapies#takeaway) ### Key Takeaways - If you have major depressive disorder (MDD) and your symptoms don’t respond to a single antidepressant, combining specific antidepressants may be more effective. - Atypical antidepressants, such as bupropion, can be used alone or with SSRIs or SNRIs to treat MDD. Antipsychotics may also be effective when other treatments don’t work or for MDD with psychosis. - If a single antidepressant isn’t working after 6 to 8 weeks, a doctor may adjust the medication or add another to the regimen to improve effectiveness. Only a healthcare professional can advise if it’s safe to combine prescription medications. If you have [major depressive disorder (MDD)](https://www.healthline.com/health/clinical-depression), you may be taking an antidepressant. Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade. ## [The role of medications]() Until recently, doctors prescribed an [antidepressant](https://www.healthline.com/health/depression/antidepressants-pros-and-cons) medication from only a single class of drugs, one medication at a time, called monotherapy. Doctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely. [Research from 2022](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2789300) now suggests that taking a combination of a specific class of antidepressants that includes mianserin, [mirtazapine](https://www.medicalnewstoday.com/articles/mirtazapine-oral-tablet), or [trazodone](https://www.healthline.com/health/drugs/trazodone-oral-tablet) may more effectively treat cases of acute to [severe depression](https://www.healthline.com/health/depression/crippling-depression) and those who didn’t respond to monotherapy. ## [Atypical antidepressants]() [Atypical antidepressants](https://www.ncbi.nlm.nih.gov/books/NBK538182/) work by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of: - [dopamine](https://www.healthline.com/health/dopamine-effects) - norepinephrine - [serotonin](https://www.healthline.com/health/mental-health/serotonin) ### Bupropion On its own, [bupropion](https://www.healthline.com/health/bupropion-oral-tablet) effectively treats [MDD](https://www.healthline.com/health/clinical-depression). But a doctor may also prescribe it with other medications for depression that is difficult to treat. Bupropion is one of the most commonly used combination therapy medications. Medical professionals often use it with [selective serotonin reuptake inhibitors (SSRIs)](https://www.healthline.com/health/depression/selective-serotonin-reuptake-inhibitors-ssris) and [serotonin-norepinephrine reuptake inhibitors (SNRIs)](https://www.healthline.com/health/depression/serotonin-norepinephrine-reuptake-inhibitors-snris). People who’ve experienced severe [side effects](https://www.healthline.com/health/antidepressant-side-effects) from other [antidepressant medications](https://www.healthline.com/health/depression/medication-list) generally tolerate bupropion. It may also relieve some of the [sexual side effects](https://www.healthline.com/health/erectile-dysfunction/antidepressant-sexual-side-effects) associated with some SSRIs and SNRIs. Mirtazapine may be an option for people experiencing loss of appetite and [insomnia](https://www.healthline.com/health/types-of-insomnia). Its most common side effects are [unintentional weight gain](https://www.healthline.com/health/antidepressants-that-cause-weight-gain) and sedation. However, in-depth studies on its use as a combination medication aren’t available. ### Antipsychotics [Research](https://psychiatryonline.org/doi/10.1176/appi.ajp.20230025) published in 2023 suggests atypical [antipsychotics](https://www.healthline.com/health/mental-health/what-are-antipsychotics) may effectively treat [treatment-resistant depression](https://www.healthline.com/health/treatment-resistant-depression). Food and Drug Administration (FDA) approved antipsychotics include: - [aripiprazole](https://www.healthline.com/health/aripiprazole-oral-tablet) - brexpiprazole - extended-release quetiapine - [cariprazine](https://www.healthline.com/health/drugs/vraylar) Current research also suggests a benefit of taking SSRIs and an antipsychotic for those with [MDD with psychosis](https://www.healthline.com/health/depression/psychotic-depression). A [2024 review](https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366\(24\)00006-3/abstract) of 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis. [Antipsychotics](https://www.healthline.com/health/mental-health/what-are-antipsychotics), however, may have some [side effects](https://www.ncbi.nlm.nih.gov/books/NBK519503/): - unintentional [weight gain](https://www.healthline.com/health/mental-health/weight-gain-on-antipsychotics) - changes in muscle control or movement ([tardive dyskinesia](https://www.healthline.com/health/tardive-dyskinesia)) - [metabolic syndrome](https://pmc.ncbi.nlm.nih.gov/articles/PMC8001502/) Carefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some [depression symptoms](https://www.healthline.com/health/video/5-symptoms-depression). ### L-triiodothyronine Some doctors use L-triiodothyronine (T3) in combination with SSRIs. [Research from 2021](https://www.sciencedirect.com/science/article/abs/pii/S2468171720300144) suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary. The typical starting dose of T3 is [25 micrograms (mcg)](https://labeling.pfizer.com/showlabeling.aspx?id=703) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to [50 mcg daily](https://www.psychiatrist.com/jcp/thyroid-hormone-use-in-mood-disorders/). ### Stimulants Dextroamphetamine ([Dexedrine](https://www.healthline.com/health/drugs/dextroamphetamine-oral-tablet)) and [methylphenidate (Ritalin)](https://www.medicalnewstoday.com/articles/drugs-ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications. Many clinicians find that supplementing antidepressants with low doses of stimulants, such as [methylphenidate](https://www.healthline.com/health/drugs/methylphenidate-oral-tablet), [may help improve depression](https://link.springer.com/article/10.1007/s40501-023-00307-4) that doesn’t respond well to treatment. However, not all clinical trials have shown benefits from this strategy. Stimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination. ## [The takeaway]() Monotherapy’s success rates [are low](https://www.aafp.org/pubs/afp/issues/2022/1000/poems-antidepressant-therapy.html) compared to combination therapy with a certain type of antidepressant. Many researchers and doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression. Many doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective. If the medication doesn’t work as desired after a trial period — usually about [6 to 8 weeks](https://www.healthquality.va.gov/guidelines/MH/mdd/) — your doctor may change your medication or add one to see whether the combination helps. »MORE:[Get a refill for your medication in as little as 15 minutes with Optum Now Online Care.](https://now.optum.com/online-care/prescription-refill?utm_source=healthline&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-rxrefill&utm_campaign=hl-article-oc-on-backlink) Optum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.healthline.com/about/brand-and-product-vetting) ### How we reviewed this article: Sources History Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.healthline.com/about/process). - Carli M, et al. (2021). Atypical antipsychotics and metabolic syndrome: From molecular mechanisms to clinical differences. <https://pmc.ncbi.nlm.nih.gov/articles/PMC8001502/> - Chokhawala K, et al. (2023). Antipsychotic medications. <https://www.ncbi.nlm.nih.gov/books/NBK519503/> - Clinical practice guideline for the treatment of depression across three age cohorts. (2024). <https://www.apa.org/depression-guideline> - Cytomel (liothyronine sodium) tablets, for oral use. (2019). <https://labeling.pfizer.com/showlabeling.aspx?id=703> - Hajnas N, et al. (2021). T3 augmentation in major depressive disorder: Sex and age differences. <https://www.sciencedirect.com/science/article/abs/pii/S2468171720300144> - Henssler J, et al. (2022). Combining antidepressants vs antidepressant monotherapy for treatment of patients with acute depression. <https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2789300> - Janela D, et al. (2023). Psychostimulant augmentation of antidepressant therapy in depression: A systematic review and meta-analysis. <https://link.springer.com/article/10.1007/s40501-023-00307-4> - Jha MK, et al. (2023). Pharmacotherapies for treatment-resistant depression: How antipsychotics fit the rapidly evolving therapeutic landscape. <https://psychiatryonline.org/doi/10.1176/appi.ajp.20230025> - Oliva V, et al. (2024). Pharmacological treatments for psychotic depression: A systematic review and network meta-analysis. <https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00006-3/abstract> - Sheffler ZM, et al. (2023). Antidepressants. <https://www.ncbi.nlm.nih.gov/books/NBK538182/> - Singh B, et al. (2022). Thyroid hormone use in mood disorders: Revisiting the evidence. <https://www.psychiatrist.com/jcp/thyroid-hormone-use-in-mood-disorders/> - Slawson DC. (2022). Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression. <https://www.aafp.org/pubs/afp/issues/2022/1000/poems-antidepressant-therapy.html> - VA/DoD clinical practice guideline for the management of major depressive disorder. (2016). <https://www.healthquality.va.gov/guidelines/MH/mdd/VADoDMDDCPGFINAL82916.pdf> Share this article ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2022/05/Yalda-Safai-500x500-Bio1.png?w=105&h=105) [Medically reviewed]() by [Yalda Safai, MD, MPH]() — Written by [Kimberly Holland]() and Dana Robinson — [Updated on November 15, 2024]() ## related stories - [Can You Overdose on Antidepressants?](https://www.healthline.com/health/can-you-overdose-on-antidepressants?utm_source=ReadNext) - [How to Manage Treatment-Resistant Depression](https://www.healthline.com/health/treatment-resistant-depression?utm_source=ReadNext) - [Switching Antidepressants: Charts, Strategies, and More](https://www.healthline.com/health/mdd/switching-antidepressants?utm_source=ReadNext) - [How to Deal with the Sexual Side Effects of Depression Treatments](https://www.healthline.com/health/depression/sexual-side-effects-depression-treatments?utm_source=ReadNext) - [What Are the Benefits of Getting Off Antidepressants?](https://www.healthline.com/health/depression/benefits-of-getting-off-antidepressants?utm_source=ReadNext) ### Read this next - [Can You Overdose on Antidepressants?](https://www.healthline.com/health/can-you-overdose-on-antidepressants?utm_source=ReadNext) Medically reviewed by [Dena Westphalen, PharmD](https://www.healthline.com/medical-team) [Antidepressants are used to treat symptoms of depression, chronic pain, and other mood disorders. But can you accidentally overdose? Are they safe?](https://www.healthline.com/health/can-you-overdose-on-antidepressants?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/can-you-overdose-on-antidepressants?utm_source=ReadNext) - [How to Manage Treatment-Resistant Depression](https://www.healthline.com/health/treatment-resistant-depression?utm_source=ReadNext) [Treatment-resistant depression refers to depression that doesn’t respond to common treatments. Despite the name, there are still treatments that can…](https://www.healthline.com/health/treatment-resistant-depression?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/treatment-resistant-depression?utm_source=ReadNext) - [Switching Antidepressants: Charts, Strategies, and More](https://www.healthline.com/health/mdd/switching-antidepressants?utm_source=ReadNext) [Switching antidepressants needs to be done carefully and with the help of your doctor. Learn more here.](https://www.healthline.com/health/mdd/switching-antidepressants?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/mdd/switching-antidepressants?utm_source=ReadNext) - [How to Deal with the Sexual Side Effects of Depression Treatments](https://www.healthline.com/health/depression/sexual-side-effects-depression-treatments?utm_source=ReadNext) Medically reviewed by [Jennifer Litner, PhD, LMFT, CST](https://www.healthline.com/medical-team) [Treatments for depression can impact your sexual function. Find out which treatments are most and least likely to have these effects and solutions you…](https://www.healthline.com/health/depression/sexual-side-effects-depression-treatments?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/depression/sexual-side-effects-depression-treatments?utm_source=ReadNext) - [What Are the Benefits of Getting Off Antidepressants?](https://www.healthline.com/health/depression/benefits-of-getting-off-antidepressants?utm_source=ReadNext) Medically reviewed by [Nicole Washington, DO, MPH](https://www.healthline.com/medical-team) [Stopping antidepressants should be done with guidance from your doctor but here's how you may benefit from stopping your antidepressants.](https://www.healthline.com/health/depression/benefits-of-getting-off-antidepressants?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/depression/benefits-of-getting-off-antidepressants?utm_source=ReadNext) - [The Power of Glimmers and Joy Lists](https://www.healthline.com/health/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext) Medically reviewed by [Jennifer Litner, PhD, LMFT, CST](https://www.healthline.com/medical-team) [Looking for an easy and effective self-care tool? Glimmers and joy lists will make you smile.](https://www.healthline.com/health/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext) - [How Long Does Wellbutrin Take to Work? And Other Reddit Questions Answered](https://www.healthline.com/health/drugs/wellbutrin-reddit?utm_source=ReadNext) [Get answers to common Reddit questions about starting Wellbutrin such as: How long does it take to start working? Can you make it work faster? And…](https://www.healthline.com/health/drugs/wellbutrin-reddit?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/drugs/wellbutrin-reddit?utm_source=ReadNext) - [Antidepressant Side Effects Like Weight, Blood Pressure Changes Vary by Drug](https://www.healthline.com/health-news/antidepressant-side-effects-vary-widely-by-drug?utm_source=ReadNext) [A large new study found that the side effects of antidepressants vary significantly by drug. 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Learn more…](https://www.healthline.com/health/depression-vs-seasonal?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/depression-vs-seasonal?utm_source=ReadNext) - [What Is the Geriatric Depression Scale?](https://www.healthline.com/health/geriatric-depression-scale?utm_source=ReadNext) [The geriatric depression scale is a screening tool that can help identify depression in older adults. Learn about the different versions, their uses…](https://www.healthline.com/health/geriatric-depression-scale?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/geriatric-depression-scale?utm_source=ReadNext) © 2026 Healthline Media LLC. All rights reserved. Healthline Media is an RVO Health Company. Our website services, content, and products are for informational purposes only. Healthline Media does not provide medical advice, diagnosis, or treatment. 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Readable Markdown	Combination drug therapy is a type of treatment that many doctors and psychiatrists have been increasingly using during the past decade. Until recently, doctors prescribed an [antidepressant](https://www.healthline.com/health/depression/antidepressants-pros-and-cons) medication from only a single class of drugs, one medication at a time, called monotherapy. Doctors generally start at a lower dosage and increase it before ruling it out as ineffective. If that happens, they might try another medication within that class or switch to another class of antidepressants entirely. [Research from 2022](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2789300) now suggests that taking a combination of a specific class of antidepressants that includes mianserin, [mirtazapine](https://www.medicalnewstoday.com/articles/mirtazapine-oral-tablet), or [trazodone](https://www.healthline.com/health/drugs/trazodone-oral-tablet) may more effectively treat cases of acute to [severe depression](https://www.healthline.com/health/depression/crippling-depression) and those who didn’t respond to monotherapy. [Atypical antidepressants](https://www.ncbi.nlm.nih.gov/books/NBK538182/) work by affecting the neurotransmitters in your brain. These neurotransmitters directly affect your levels of: - [dopamine](https://www.healthline.com/health/dopamine-effects) - norepinephrine - [serotonin](https://www.healthline.com/health/mental-health/serotonin) Bupropion On its own, [bupropion](https://www.healthline.com/health/bupropion-oral-tablet) effectively treats [MDD](https://www.healthline.com/health/clinical-depression). But a doctor may also prescribe it with other medications for depression that is difficult to treat. Mirtazapine may be an option for people experiencing loss of appetite and [insomnia](https://www.healthline.com/health/types-of-insomnia). Its most common side effects are [unintentional weight gain](https://www.healthline.com/health/antidepressants-that-cause-weight-gain) and sedation. However, in-depth studies on its use as a combination medication aren’t available. Antipsychotics - [aripiprazole](https://www.healthline.com/health/aripiprazole-oral-tablet) - brexpiprazole - extended-release quetiapine - [cariprazine](https://www.healthline.com/health/drugs/vraylar) Current research also suggests a benefit of taking SSRIs and an antipsychotic for those with [MDD with psychosis](https://www.healthline.com/health/depression/psychotic-depression). A [2024 review](https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366\(24\)00006-3/abstract) of 16 studies found that the combination of an SSRI and an antipsychotic medication showed higher treatment responses than a placebo in those with MDD with features of psychosis. - unintentional [weight gain](https://www.healthline.com/health/mental-health/weight-gain-on-antipsychotics) - changes in muscle control or movement ([tardive dyskinesia](https://www.healthline.com/health/tardive-dyskinesia)) - [metabolic syndrome](https://pmc.ncbi.nlm.nih.gov/articles/PMC8001502/) Carefully consider the pros and cons of antipsychotics with your doctor. Their side effects may prolong or worsen some [depression symptoms](https://www.healthline.com/health/video/5-symptoms-depression). L-triiodothyronine Some doctors use L-triiodothyronine (T3) in combination with SSRIs. [Research from 2021](https://www.sciencedirect.com/science/article/abs/pii/S2468171720300144) suggests that T3 with an SSRI may lead to a faster response to treatment compared with taking an SSRI alone for older men. But more research is necessary. The typical starting dose of T3 is [25 micrograms (mcg)](https://labeling.pfizer.com/showlabeling.aspx?id=703) daily. If that dosage doesn’t provide the desired results after 1 to 2 weeks, they may increase it to [50 mcg daily](https://www.psychiatrist.com/jcp/thyroid-hormone-use-in-mood-disorders/). Stimulants Dextroamphetamine ([Dexedrine](https://www.healthline.com/health/drugs/dextroamphetamine-oral-tablet)) and [methylphenidate (Ritalin)](https://www.medicalnewstoday.com/articles/drugs-ritalin) are stimulants that medical professionals may use to treat depression. Doctors may prescribe them alone or in combination with antidepressant medications. Many clinicians find that supplementing antidepressants with low doses of stimulants, such as [methylphenidate](https://www.healthline.com/health/drugs/methylphenidate-oral-tablet), [may help improve depression](https://link.springer.com/article/10.1007/s40501-023-00307-4) that doesn’t respond well to treatment. However, not all clinical trials have shown benefits from this strategy. Stimulants are most helpful when the desired effect is a quick response. People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination. Monotherapy’s success rates [are low](https://www.aafp.org/pubs/afp/issues/2022/1000/poems-antidepressant-therapy.html) compared to combination therapy with a certain type of antidepressant. Many researchers and doctors believe combination treatments are a first-line approach to treating MDD and treatment-resistant depression. Many doctors will still begin treatment with a single antidepressant medication. You’ll need to give it time to work before ruling it out as ineffective. If the medication doesn’t work as desired after a trial period — usually about [6 to 8 weeks](https://www.healthquality.va.gov/guidelines/MH/mdd/) — your doctor may change your medication or add one to see whether the combination helps. Optum Now is operated by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.healthline.com/about/brand-and-product-vetting)
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