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| URL | https://www.healthline.com/health/coronavirus-treatment |
| Last Crawled | 2026-04-01 11:31:13 (11 days ago) |
| First Indexed | 2020-03-15 02:23:19 (6 years ago) |
| HTTP Status Code | 200 |
| Meta Title | Coronavirus Treatment: Remdesivir & Other Drugs |
| Meta Description | Get the facts on coronavirus treatment. Discover which COVID-19 medications have been FDA-approved or authorized, other experimental medications, and more. |
| Meta Canonical | null |
| Boilerpipe Text | COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019.
Since the initial outbreak, the novel coronavirus has spread to most countries around the world. Itâs been responsible for
tens of millions of infections
globally, causing well over 2 million deaths. The United States is the most affected country.
Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19.
The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop
symptoms of COVID-19
experience:
fever
cough
shortness of breath
fatigue
Less common symptoms include:
chills
, with or without repeated shaking
headache
loss of taste or smell
sore throat
muscle aches and pains
a stuffy or runny nose
diarrhea, nausea, vomiting, and other gastrointestinal symptoms
discolored fingers or
toes
pink eye
Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms.
HEALTHLINEâS CORONAVIRUS COVERAGE
Stay informed with our
live updates
about the current COVID-19 outbreak.
Also, visit our
coronavirus hub
for more information on how to prepare, advice on prevention and treatment, and expert recommendations.
Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola.
Researchers
have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells.
This intravenous (IV) infusion therapy is used to treat people 12 years old and older whoâve been hospitalized with the condition. To date, itâs still the only COVID-19 treatment thatâs been approved by the FDA.
Authorized treatments
EUAs allow products that havenât received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives.
The COVID-19 medications that have received EUAs are:
bamlanivimab
a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab)
casirivimab and imdevimab, which must be administered together
the oral medication baricitinib (Olumiant), which must be administered with remdesivir
COVID-19 convalescent plasma
Fresenius Kabi Propoven 2%, an IV sedative
Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT)
REGIOCIT replacement solution with citrate for people who need CRRT
Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight.
Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, theyâre administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization.
The other medications are all intended for people whoâve been hospitalized or are at risk for hospitalization.
A
January 2021 study
on convalescent plasma looked at effects on adults age 65 and older whoâd tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group whoâd received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group whoâd received a placebo.
Convalescent plasma must be administered early into the onset of symptoms to be effective.
In February 2021, the
FDA
updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used.
Other treatments
If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve:
fluids to reduce the risk of
dehydration
medication to reduce a fever
supplemental oxygen
in more severe cases
People who have a hard time breathing due to COVID-19 may need a
ventilator
.
Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission.
Learn more.
However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19.
Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available.
Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms.
Chloroquine
Chloroquine is a drug thatâs used to fight malaria and autoimmune diseases. Itâs been in use for more than 70 years and is generally considered safe.
At the beginning of the pandemic,
researchers
discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies.
However, a
February 2021 literature review
concluded that there wasnât enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquineâs role as a COVID-19 treatment.
Lopinavir and ritonavir
Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV.
In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a
significant reduction
in his levels of the coronavirus.
Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs.
According to a
February 2021 study
published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didnât definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays.
Favilavir (favipiravir)
In February 2020, China
approved
the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. Itâs also commonly known as favipiravir.
The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people.
A
January 2021 study
in ACS Central Science concluded that favilavir and the antiviral drug ribavirin werenât as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA.
Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, theyâre usually mild and tend to come on slowly.
COVID-19 seems to cause more severe symptoms in
older adults
and people with underlying health conditions, such as chronic heart or lung conditions.
If you think you have symptoms of COVID-19, follow this protocol:
Call the doctor.
If you have
mild symptoms
, call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested.
Stay home.
If you have symptoms of COVID-19 or another type of
viral infection
, stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones.
COVID-19 is so common now that exposure is likely. If youâre feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating).
You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19.
About 80 percent
of people recover from COVID-19 without needing hospitalization or special treatment.
If youâre young and healthy and experience only mild symptoms, a doctor will likely advise you to
isolate yourself at home
and limit contact with others in your household. Youâll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely.
If youâre an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action.
If your symptoms worsen despite home care, itâs important to get prompt medical care.
The symptoms that indicate a medical emergency are:
having trouble breathing
blue lips or a blue face
persistent chest pain or pressure in the chest
confusion
severe drowsiness
Call the local hospital, clinic, or urgent care to let them know youâll be coming in, and wear a
face mask
once you leave your home. You can also call 911 or your local emergency services for immediate medical attention.
The novel coronavirus is primarily
transmitted from person to person
. At this point, the best way to prevent infection is to avoid being around people whoâve been exposed to the virus.
Also, according to the
CDC
, you can take the following precautions to lower your risk of infection:
Wash your hands
thoroughly
with soap and water
for at least 20 seconds.
Use hand sanitizer
with at least 60 percent alcohol if soap isnât available.
Avoid touching your face
unless youâve recently washed your hands.
Stay clear of people
who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick.
Avoid crowded areas
as much as possible.
Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus.
At the moment, the FDA has approved only one drug â remdesivir (Veklury) â for the treatment of COVID-19. A few drugs have received EUAs, though.
Thereâs little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective. |
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# Current Treatments for COVID-19

[Medically reviewed]() by [Joseph Vinetz, MD]() â Written by [Daniel Yetman]() â [Updated on February 18, 2021]()
- [Available treatment](https://www.healthline.com/health/coronavirus-treatment#available-treatment)
- [Experimental treatments](https://www.healthline.com/health/coronavirus-treatment#experimental-treatments)
- [If you have symptoms](https://www.healthline.com/health/coronavirus-treatment#if-you-have-symptoms)
- [When to seek care](https://www.healthline.com/health/coronavirus-treatment#when-to-seek-care)
- [Prevention](https://www.healthline.com/health/coronavirus-treatment#prevention)
- [Bottom line](https://www.healthline.com/health/coronavirus-treatment#bottom-line)

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COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019.
Since the initial outbreak, the novel coronavirus has spread to most countries around the world. Itâs been responsible for [tens of millions of infections](https://coronavirus.jhu.edu/map.html) globally, causing well over 2 million deaths. The United States is the most affected country.
Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19.
The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop [symptoms of COVID-19](https://www.healthline.com/health/coronavirus-symptoms) experience:
- [fever](https://www.healthline.com/health/fever)
- [cough](https://www.healthline.com/health/how-long-does-a-cough-last)
- [shortness of breath](https://www.healthline.com/health/coronavirus-shortness-of-breath)
- [fatigue](https://www.healthline.com/health/fatigue)
Less common symptoms include:
- [chills](https://www.healthline.com/health/chills), with or without repeated shaking
- [headache](https://www.healthline.com/health/is-headache-a-sign-of-coronavirus)
- [loss of taste or smell](https://www.healthline.com/health/coronavirus-loss-of-taste-loss-of-smell)
- [sore throat](https://www.healthline.com/health/sore-throat-coronavirus)
- [muscle aches and pains](https://www.healthline.com/health/muscle-aches)
- a stuffy or runny nose
- [diarrhea, nausea, vomiting, and other gastrointestinal symptoms](https://www.healthline.com/health/coronavirus-diarrhea)
- discolored fingers or [toes](https://www.healthline.com/health/covid-toe-rash)
- [pink eye](https://www.healthline.com/health/coronavirus-pink-eye)
Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms.
> **HEALTHLINEâS CORONAVIRUS COVERAGE**
>
> Stay informed with our [live updates](https://www.healthline.com/health-news/coronavirus-live-updates) about the current COVID-19 outbreak.
>
> Also, visit our [coronavirus hub](https://www.healthline.com/coronavirus) for more information on how to prepare, advice on prevention and treatment, and expert recommendations.
## [What type of treatment is available for the novel coronavirus?]()
Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola. [Researchers](https://www.nejm.org/doi/full/10.1056/NEJMoa2007764) have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells.
In October 2020, it became the first drug [approved by the Food and Drug Administration (FDA)](https://www.fda.gov/drugs/drug-safety-and-availability/fdas-approval-veklury-remdesivir-treatment-covid-19-science-safety-and-effectiveness) to treat COVID-19.
This intravenous (IV) infusion therapy is used to treat people 12 years old and older whoâve been hospitalized with the condition. To date, itâs still the only COVID-19 treatment thatâs been approved by the FDA.
### Authorized treatments
The FDA has also granted [emergency use authorizations (EUAs)](https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization) for some medications.
EUAs allow products that havenât received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives.
The COVID-19 medications that have received EUAs are:
- bamlanivimab
- a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab)
- casirivimab and imdevimab, which must be administered together
- the oral medication baricitinib (Olumiant), which must be administered with remdesivir
- [COVID-19 convalescent plasma](https://www.healthline.com/health-news/why-the-fda-approval-of-convalescent-plasma-is-controversial)
- Fresenius Kabi Propoven 2%, an IV sedative
- Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT)
- REGIOCIT replacement solution with citrate for people who need CRRT
Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight.
Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, theyâre administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization.
The other medications are all intended for people whoâve been hospitalized or are at risk for hospitalization.
A [January 2021 study](https://www.nejm.org/doi/10.1056/NEJMoa2033700) on convalescent plasma looked at effects on adults age 65 and older whoâd tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group whoâd received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group whoâd received a placebo.
Convalescent plasma must be administered early into the onset of symptoms to be effective.
In February 2021, the [FDA](https://www.fda.gov/media/136798/download) updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used.
### Other treatments
If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve:
- fluids to reduce the risk of [dehydration](https://www.healthline.com/health/how-to-tell-if-youre-dehydrated)
- medication to reduce a fever
- [supplemental oxygen](https://www.healthline.com/health/oxygen-therapy) in more severe cases
People who have a hard time breathing due to COVID-19 may need a [ventilator](https://www.healthline.com/health/ventilator).
**»Online Care:**[For \$29, get personalized, expert care and prescriptions for COVID-19 in minutes. Available 24/7 on Optum Perks.](https://perks.optum.com/online-care/covid-19?utm_source=healthline&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-other-skin-condition&utm_campaign=hl-article-oc-on-backlink&correlationId=null)
Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.healthline.com/about/brand-and-product-vetting)
## [What else is being done to find an effective treatment?]()
*The CDC* [*recommends*](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html) *that all people wear cloth face masks in public places where itâs difficult to maintain a 6-foot distance from others. This will help slow the spread of the virus from people without symptoms or people who do not know they have contracted the virus. Cloth face masks should be worn while continuing to practice physical distancing.*
***Note:*** *Itâs critical to reserve surgical masks and N95 respirators for healthcare workers.*
[Vaccines and treatment options](https://www.healthline.com/health-news/heres-exactly-where-were-at-with-vaccines-and-treatments-for-covid-19) for COVID-19 are currently being investigated around the world.
However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19.
Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available.
Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms.
### Chloroquine
Chloroquine is a drug thatâs used to fight malaria and autoimmune diseases. Itâs been in use for more than 70 years and is generally considered safe.
At the beginning of the pandemic, [researchers](https://www.nature.com/articles/s41422-020-0282-0) discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies.
However, a [February 2021 literature review](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full) concluded that there wasnât enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquineâs role as a COVID-19 treatment.
### Lopinavir and ritonavir
Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV.
In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a [significant reduction](https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79) in his levels of the coronavirus.
Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs.
According to a [February 2021 study](https://www.nejm.org/doi/full/10.1056/NEJMoa2023184) published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didnât definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays.
### Favilavir (favipiravir)
In February 2020, China [approved](https://www.upi.com/Health_News/2020/02/17/China-approves-antiviral-favilavir-to-treat-coronavirus/5291581953892) the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. Itâs also commonly known as favipiravir.
The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people.
A [January 2021 study](https://pubs.acs.org/doi/full/10.1021/acscentsci.0c01242) in ACS Central Science concluded that favilavir and the antiviral drug ribavirin werenât as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA.
## [What should you do if you think you have COVID-19 symptoms?]()
Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, theyâre usually mild and tend to come on slowly.
COVID-19 seems to cause more severe symptoms in [older adults](https://www.healthline.com/health/coronavirus-tips-and-advice-for-older-adults) and people with underlying health conditions, such as chronic heart or lung conditions.
If you think you have symptoms of COVID-19, follow this protocol:
1. **Call the doctor.** If you have [mild symptoms](https://www.healthline.com/health/mild-covid-symptoms), call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested.
2. **Stay home.** If you have symptoms of COVID-19 or another type of [viral infection](https://www.healthline.com/health/bacterial-vs-viral-infections), stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones.
COVID-19 is so common now that exposure is likely. If youâre feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating).
You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19.
## [When do you need medical care?]()
[About 80 percent](https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19) of people recover from COVID-19 without needing hospitalization or special treatment.
If youâre young and healthy and experience only mild symptoms, a doctor will likely advise you to [isolate yourself at home](https://www.healthline.com/health/do-you-have-to-quarantine-if-you-have-been-vaccinated) and limit contact with others in your household. Youâll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely.
If youâre an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action.
If your symptoms worsen despite home care, itâs important to get prompt medical care.
The symptoms that indicate a medical emergency are:
- having trouble breathing
- blue lips or a blue face
- persistent chest pain or pressure in the chest
- confusion
- severe drowsiness
Call the local hospital, clinic, or urgent care to let them know youâll be coming in, and wear a [face mask](https://www.healthline.com/health/best-face-masks-covid-specific) once you leave your home. You can also call 911 or your local emergency services for immediate medical attention.
## [How can you avoid infection with the novel coronavirus?]()
The novel coronavirus is primarily [transmitted from person to person](https://www.healthline.com/health/coronavirus-transmission). At this point, the best way to prevent infection is to avoid being around people whoâve been exposed to the virus.
Also, according to the [CDC](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html), you can take the following precautions to lower your risk of infection:
- **Wash your hands** thoroughly [with soap and water](https://www.healthline.com/health/7-steps-of-handwashing) for at least 20 seconds.
- **Use hand sanitizer** with at least 60 percent alcohol if soap isnât available.
- **Avoid touching your face** unless youâve recently washed your hands.
- **Stay clear of people** who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick.
- **Avoid crowded areas** as much as possible.
Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus.
## [Whatâs the bottom line?]()
Researchers around the world are working hard to develop potential [vaccines](https://www.healthline.com/health-news/cdc-finds-covid-19-vaccines-safe-after-22-million-vaccinations) and treatments. Get vaccinated [as soon as youâre eligible](https://www.healthline.com/coronavirus).
At the moment, the FDA has approved only one drug â remdesivir (Veklury) â for the treatment of COVID-19. A few drugs have received EUAs, though.
Thereâs little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective.
### How we reviewed this article:
Sources
History
Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.healthline.com/about/process).
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<https://www.nejm.org/doi/full/10.1056/NEJMoa2007764>
- Byléhn F, et al. (2021). Modeling the binding mechanism of remdesivir, favilavir, and ribavirin to SARS-COV-2 RNA-dependent RNA polymerase.
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- Food and Drug Administration (FDA). (2020). FDAâs approval of Veklury (remdesivir) for the treatment of COVID-19âThe science of safety and effectiveness.
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- Food and Drug Administration (FDA). (2021). Coronavirus (COVID-19) update: FDA authorizes monoclonal antibodies for treatment of COVID-19 \[Press release\].
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- How to protect yourself & others. (2020).
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[https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Fclinical-guidance-management-patients.html\&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705576558\&sdata=fvdGtjUz1MqqT9nA5G1iHRoCMTAUjjF0eiACm%2FiJ9go%3D\&reserved=0](https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Fclinical-guidance-management-patients.html&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705576558&sdata=fvdGtjUz1MqqT9nA5G1iHRoCMTAUjjF0eiACm%2FiJ9go%3D&reserved=0)
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<https://www.fda.gov/media/136798/download>
- Libster R, et al. (2021). Early high-titer plasma therapy to prevent severe COVID-19 in older adults.
<https://www.nejm.org/doi/10.1056/NEJMoa2033700>
- Lim J, et al. (2020). Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: The application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR.
<https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79>
- Singh B, et al. (2021). Chloroquine or hydroxychloroquine for prevention and treatment of COVIDâ19.
<https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full>
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- Wang M, et al. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
<https://www.nature.com/articles/s41422-020-0282-0>
- WHO Solidarity Trial Consortium. (2021). Repurposed antiviral drugs for COVID-19 â Interim WHO Solidarity Trial results.
<https://www.nejm.org/doi/full/10.1056/NEJMoa2023184>
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[Medically reviewed]() by [Joseph Vinetz, MD]() â Written by [Daniel Yetman]() â [Updated on February 18, 2021]()
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| Readable Markdown | COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019.
Since the initial outbreak, the novel coronavirus has spread to most countries around the world. Itâs been responsible for [tens of millions of infections](https://coronavirus.jhu.edu/map.html) globally, causing well over 2 million deaths. The United States is the most affected country.
Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19.
The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop [symptoms of COVID-19](https://www.healthline.com/health/coronavirus-symptoms) experience:
- [fever](https://www.healthline.com/health/fever)
- [cough](https://www.healthline.com/health/how-long-does-a-cough-last)
- [shortness of breath](https://www.healthline.com/health/coronavirus-shortness-of-breath)
- [fatigue](https://www.healthline.com/health/fatigue)
Less common symptoms include:
- [chills](https://www.healthline.com/health/chills), with or without repeated shaking
- [headache](https://www.healthline.com/health/is-headache-a-sign-of-coronavirus)
- [loss of taste or smell](https://www.healthline.com/health/coronavirus-loss-of-taste-loss-of-smell)
- [sore throat](https://www.healthline.com/health/sore-throat-coronavirus)
- [muscle aches and pains](https://www.healthline.com/health/muscle-aches)
- a stuffy or runny nose
- [diarrhea, nausea, vomiting, and other gastrointestinal symptoms](https://www.healthline.com/health/coronavirus-diarrhea)
- discolored fingers or [toes](https://www.healthline.com/health/covid-toe-rash)
- [pink eye](https://www.healthline.com/health/coronavirus-pink-eye)
Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms.
> **HEALTHLINEâS CORONAVIRUS COVERAGE**
>
> Stay informed with our [live updates](https://www.healthline.com/health-news/coronavirus-live-updates) about the current COVID-19 outbreak.
>
> Also, visit our [coronavirus hub](https://www.healthline.com/coronavirus) for more information on how to prepare, advice on prevention and treatment, and expert recommendations.
Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola. [Researchers](https://www.nejm.org/doi/full/10.1056/NEJMoa2007764) have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells.
This intravenous (IV) infusion therapy is used to treat people 12 years old and older whoâve been hospitalized with the condition. To date, itâs still the only COVID-19 treatment thatâs been approved by the FDA.
Authorized treatments
EUAs allow products that havenât received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives.
The COVID-19 medications that have received EUAs are:
- bamlanivimab
- a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab)
- casirivimab and imdevimab, which must be administered together
- the oral medication baricitinib (Olumiant), which must be administered with remdesivir
- [COVID-19 convalescent plasma](https://www.healthline.com/health-news/why-the-fda-approval-of-convalescent-plasma-is-controversial)
- Fresenius Kabi Propoven 2%, an IV sedative
- Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT)
- REGIOCIT replacement solution with citrate for people who need CRRT
Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight.
Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, theyâre administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization.
The other medications are all intended for people whoâve been hospitalized or are at risk for hospitalization.
A [January 2021 study](https://www.nejm.org/doi/10.1056/NEJMoa2033700) on convalescent plasma looked at effects on adults age 65 and older whoâd tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group whoâd received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group whoâd received a placebo.
Convalescent plasma must be administered early into the onset of symptoms to be effective.
In February 2021, the [FDA](https://www.fda.gov/media/136798/download) updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used.
Other treatments
If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve:
- fluids to reduce the risk of [dehydration](https://www.healthline.com/health/how-to-tell-if-youre-dehydrated)
- medication to reduce a fever
- [supplemental oxygen](https://www.healthline.com/health/oxygen-therapy) in more severe cases
People who have a hard time breathing due to COVID-19 may need a [ventilator](https://www.healthline.com/health/ventilator).
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However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19.
Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available.
Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms.
Chloroquine
Chloroquine is a drug thatâs used to fight malaria and autoimmune diseases. Itâs been in use for more than 70 years and is generally considered safe.
At the beginning of the pandemic, [researchers](https://www.nature.com/articles/s41422-020-0282-0) discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies.
However, a [February 2021 literature review](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full) concluded that there wasnât enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquineâs role as a COVID-19 treatment.
Lopinavir and ritonavir
Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV.
In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a [significant reduction](https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79) in his levels of the coronavirus.
Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs.
According to a [February 2021 study](https://www.nejm.org/doi/full/10.1056/NEJMoa2023184) published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didnât definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays.
Favilavir (favipiravir)
In February 2020, China [approved](https://www.upi.com/Health_News/2020/02/17/China-approves-antiviral-favilavir-to-treat-coronavirus/5291581953892) the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. Itâs also commonly known as favipiravir.
The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people.
A [January 2021 study](https://pubs.acs.org/doi/full/10.1021/acscentsci.0c01242) in ACS Central Science concluded that favilavir and the antiviral drug ribavirin werenât as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA.
Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, theyâre usually mild and tend to come on slowly.
COVID-19 seems to cause more severe symptoms in [older adults](https://www.healthline.com/health/coronavirus-tips-and-advice-for-older-adults) and people with underlying health conditions, such as chronic heart or lung conditions.
If you think you have symptoms of COVID-19, follow this protocol:
1. **Call the doctor.** If you have [mild symptoms](https://www.healthline.com/health/mild-covid-symptoms), call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested.
2. **Stay home.** If you have symptoms of COVID-19 or another type of [viral infection](https://www.healthline.com/health/bacterial-vs-viral-infections), stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones.
COVID-19 is so common now that exposure is likely. If youâre feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating).
You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19.
[About 80 percent](https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19) of people recover from COVID-19 without needing hospitalization or special treatment.
If youâre young and healthy and experience only mild symptoms, a doctor will likely advise you to [isolate yourself at home](https://www.healthline.com/health/do-you-have-to-quarantine-if-you-have-been-vaccinated) and limit contact with others in your household. Youâll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely.
If youâre an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action.
If your symptoms worsen despite home care, itâs important to get prompt medical care.
The symptoms that indicate a medical emergency are:
- having trouble breathing
- blue lips or a blue face
- persistent chest pain or pressure in the chest
- confusion
- severe drowsiness
Call the local hospital, clinic, or urgent care to let them know youâll be coming in, and wear a [face mask](https://www.healthline.com/health/best-face-masks-covid-specific) once you leave your home. You can also call 911 or your local emergency services for immediate medical attention.
The novel coronavirus is primarily [transmitted from person to person](https://www.healthline.com/health/coronavirus-transmission). At this point, the best way to prevent infection is to avoid being around people whoâve been exposed to the virus.
Also, according to the [CDC](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html), you can take the following precautions to lower your risk of infection:
- **Wash your hands** thoroughly [with soap and water](https://www.healthline.com/health/7-steps-of-handwashing) for at least 20 seconds.
- **Use hand sanitizer** with at least 60 percent alcohol if soap isnât available.
- **Avoid touching your face** unless youâve recently washed your hands.
- **Stay clear of people** who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick.
- **Avoid crowded areas** as much as possible.
Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus.
At the moment, the FDA has approved only one drug â remdesivir (Veklury) â for the treatment of COVID-19. A few drugs have received EUAs, though.
Thereâs little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective. |
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