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URLhttps://www.healthline.com/health/coronavirus-treatment
Last Crawled2026-04-01 11:31:13 (11 days ago)
First Indexed2020-03-15 02:23:19 (6 years ago)
HTTP Status Code200
Meta TitleCoronavirus Treatment: Remdesivir & Other Drugs
Meta DescriptionGet the facts on coronavirus treatment. Discover which COVID-19 medications have been FDA-approved or authorized, other experimental medications, and more.
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COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019. Since the initial outbreak, the novel coronavirus has spread to most countries around the world. It’s been responsible for tens of millions of infections globally, causing well over 2 million deaths. The United States is the most affected country. Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19. The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop symptoms of COVID-19 experience: fever cough shortness of breath fatigue Less common symptoms include: chills , with or without repeated shaking headache loss of taste or smell sore throat muscle aches and pains a stuffy or runny nose diarrhea, nausea, vomiting, and other gastrointestinal symptoms discolored fingers or toes pink eye Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms. HEALTHLINE’S CORONAVIRUS COVERAGE Stay informed with our live updates about the current COVID-19 outbreak. Also, visit our coronavirus hub for more information on how to prepare, advice on prevention and treatment, and expert recommendations. Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola. Researchers have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells. This intravenous (IV) infusion therapy is used to treat people 12 years old and older who’ve been hospitalized with the condition. To date, it’s still the only COVID-19 treatment that’s been approved by the FDA. Authorized treatments EUAs allow products that haven’t received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives. The COVID-19 medications that have received EUAs are: bamlanivimab a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab) casirivimab and imdevimab, which must be administered together the oral medication baricitinib (Olumiant), which must be administered with remdesivir COVID-19 convalescent plasma Fresenius Kabi Propoven 2%, an IV sedative Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT) REGIOCIT replacement solution with citrate for people who need CRRT Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight. Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, they’re administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization. The other medications are all intended for people who’ve been hospitalized or are at risk for hospitalization. A January 2021 study on convalescent plasma looked at effects on adults age 65 and older who’d tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group who’d received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group who’d received a placebo. Convalescent plasma must be administered early into the onset of symptoms to be effective. In February 2021, the FDA updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used. Other treatments If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve: fluids to reduce the risk of dehydration medication to reduce a fever supplemental oxygen in more severe cases People who have a hard time breathing due to COVID-19 may need a ventilator . Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. Learn more. However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19. Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available. Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms. Chloroquine Chloroquine is a drug that’s used to fight malaria and autoimmune diseases. It’s been in use for more than 70 years and is generally considered safe. At the beginning of the pandemic, researchers discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies. However, a February 2021 literature review concluded that there wasn’t enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquine’s role as a COVID-19 treatment. Lopinavir and ritonavir Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV. In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a significant reduction in his levels of the coronavirus. Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs. According to a February 2021 study published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didn’t definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays. Favilavir (favipiravir) In February 2020, China approved the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. It’s also commonly known as favipiravir. The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people. A January 2021 study in ACS Central Science concluded that favilavir and the antiviral drug ribavirin weren’t as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA. Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, they’re usually mild and tend to come on slowly. COVID-19 seems to cause more severe symptoms in older adults and people with underlying health conditions, such as chronic heart or lung conditions. If you think you have symptoms of COVID-19, follow this protocol: Call the doctor. If you have mild symptoms , call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested. Stay home. If you have symptoms of COVID-19 or another type of viral infection , stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones. COVID-19 is so common now that exposure is likely. If you’re feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating). You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19. About 80 percent of people recover from COVID-19 without needing hospitalization or special treatment. If you’re young and healthy and experience only mild symptoms, a doctor will likely advise you to isolate yourself at home and limit contact with others in your household. You’ll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely. If you’re an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action. If your symptoms worsen despite home care, it’s important to get prompt medical care. The symptoms that indicate a medical emergency are: having trouble breathing blue lips or a blue face persistent chest pain or pressure in the chest confusion severe drowsiness Call the local hospital, clinic, or urgent care to let them know you’ll be coming in, and wear a face mask once you leave your home. You can also call 911 or your local emergency services for immediate medical attention. The novel coronavirus is primarily transmitted from person to person . At this point, the best way to prevent infection is to avoid being around people who’ve been exposed to the virus. Also, according to the CDC , you can take the following precautions to lower your risk of infection: Wash your hands thoroughly with soap and water for at least 20 seconds. Use hand sanitizer with at least 60 percent alcohol if soap isn’t available. Avoid touching your face unless you’ve recently washed your hands. Stay clear of people who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick. Avoid crowded areas as much as possible. Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus. At the moment, the FDA has approved only one drug — remdesivir (Veklury) — for the treatment of COVID-19. A few drugs have received EUAs, though. There’s little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective.
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Connect with us for all things health. Subscribe [COVID-19](https://www.healthline.com/health/coronavirus-treatment) - [Vaccines Basics](https://www.healthline.com/health/how-long-does-covid-vaccine-protect-you) - [Testing](https://www.healthline.com/health/types-of-covid-tests) - [Symptoms](https://www.healthline.com/health/coronavirus-covid-19) # Current Treatments for COVID-19 ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2022/01/Joseph-Vinetz-500x500-Bio.png?w=105&h=105) [Medically reviewed]() by [Joseph Vinetz, MD]() — Written by [Daniel Yetman]() — [Updated on February 18, 2021]() - [Available treatment](https://www.healthline.com/health/coronavirus-treatment#available-treatment) - [Experimental treatments](https://www.healthline.com/health/coronavirus-treatment#experimental-treatments) - [If you have symptoms](https://www.healthline.com/health/coronavirus-treatment#if-you-have-symptoms) - [When to seek care](https://www.healthline.com/health/coronavirus-treatment#when-to-seek-care) - [Prevention](https://www.healthline.com/health/coronavirus-treatment#prevention) - [Bottom line](https://www.healthline.com/health/coronavirus-treatment#bottom-line) ![man wrapped in a blanket while holding a thermometer and looking at a tablet](https://i0.wp.com/post.healthline.com/wp-content/uploads/2020/03/male_with_fever-1296x728-header.jpg?w=1155&h=1528) [Share on Pinterest](https://www.pinterest.com/pin/create/button/?url=https%3A%2F%2Fwww.healthline.com%2Fhealth%2Fcoronavirus-treatment&media=https%3A%2F%2Fpost.healthline.com%2Fwp-content%2Fuploads%2F2020%2F03%2Fmale_with_fever-1296x728-header.jpg&description=Coronavirus%20Treatment%3A%20Remdesivir%20%26%20Other%20Drugs "Share on Pinterest") Getty Images COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019. Since the initial outbreak, the novel coronavirus has spread to most countries around the world. It’s been responsible for [tens of millions of infections](https://coronavirus.jhu.edu/map.html) globally, causing well over 2 million deaths. The United States is the most affected country. Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19. The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop [symptoms of COVID-19](https://www.healthline.com/health/coronavirus-symptoms) experience: - [fever](https://www.healthline.com/health/fever) - [cough](https://www.healthline.com/health/how-long-does-a-cough-last) - [shortness of breath](https://www.healthline.com/health/coronavirus-shortness-of-breath) - [fatigue](https://www.healthline.com/health/fatigue) Less common symptoms include: - [chills](https://www.healthline.com/health/chills), with or without repeated shaking - [headache](https://www.healthline.com/health/is-headache-a-sign-of-coronavirus) - [loss of taste or smell](https://www.healthline.com/health/coronavirus-loss-of-taste-loss-of-smell) - [sore throat](https://www.healthline.com/health/sore-throat-coronavirus) - [muscle aches and pains](https://www.healthline.com/health/muscle-aches) - a stuffy or runny nose - [diarrhea, nausea, vomiting, and other gastrointestinal symptoms](https://www.healthline.com/health/coronavirus-diarrhea) - discolored fingers or [toes](https://www.healthline.com/health/covid-toe-rash) - [pink eye](https://www.healthline.com/health/coronavirus-pink-eye) Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms. > **HEALTHLINE’S CORONAVIRUS COVERAGE** > > Stay informed with our [live updates](https://www.healthline.com/health-news/coronavirus-live-updates) about the current COVID-19 outbreak. > > Also, visit our [coronavirus hub](https://www.healthline.com/coronavirus) for more information on how to prepare, advice on prevention and treatment, and expert recommendations. ## [What type of treatment is available for the novel coronavirus?]() Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola. [Researchers](https://www.nejm.org/doi/full/10.1056/NEJMoa2007764) have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells. In October 2020, it became the first drug [approved by the Food and Drug Administration (FDA)](https://www.fda.gov/drugs/drug-safety-and-availability/fdas-approval-veklury-remdesivir-treatment-covid-19-science-safety-and-effectiveness) to treat COVID-19. This intravenous (IV) infusion therapy is used to treat people 12 years old and older who’ve been hospitalized with the condition. To date, it’s still the only COVID-19 treatment that’s been approved by the FDA. ### Authorized treatments The FDA has also granted [emergency use authorizations (EUAs)](https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization) for some medications. EUAs allow products that haven’t received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives. The COVID-19 medications that have received EUAs are: - bamlanivimab - a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab) - casirivimab and imdevimab, which must be administered together - the oral medication baricitinib (Olumiant), which must be administered with remdesivir - [COVID-19 convalescent plasma](https://www.healthline.com/health-news/why-the-fda-approval-of-convalescent-plasma-is-controversial) - Fresenius Kabi Propoven 2%, an IV sedative - Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT) - REGIOCIT replacement solution with citrate for people who need CRRT Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight. Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, they’re administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization. The other medications are all intended for people who’ve been hospitalized or are at risk for hospitalization. A [January 2021 study](https://www.nejm.org/doi/10.1056/NEJMoa2033700) on convalescent plasma looked at effects on adults age 65 and older who’d tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group who’d received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group who’d received a placebo. Convalescent plasma must be administered early into the onset of symptoms to be effective. In February 2021, the [FDA](https://www.fda.gov/media/136798/download) updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used. ### Other treatments If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve: - fluids to reduce the risk of [dehydration](https://www.healthline.com/health/how-to-tell-if-youre-dehydrated) - medication to reduce a fever - [supplemental oxygen](https://www.healthline.com/health/oxygen-therapy) in more severe cases People who have a hard time breathing due to COVID-19 may need a [ventilator](https://www.healthline.com/health/ventilator). **»Online Care:**[For \$29, get personalized, expert care and prescriptions for COVID-19 in minutes. Available 24/7 on Optum Perks.](https://perks.optum.com/online-care/covid-19?utm_source=healthline&utm_medium=organic-onlinecare-on&utm_content=linkto-oc-on-other-skin-condition&utm_campaign=hl-article-oc-on-backlink&correlationId=null) Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.healthline.com/about/brand-and-product-vetting) ## [What else is being done to find an effective treatment?]() *The CDC* [*recommends*](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html) *that all people wear cloth face masks in public places where it’s difficult to maintain a 6-foot distance from others. This will help slow the spread of the virus from people without symptoms or people who do not know they have contracted the virus. Cloth face masks should be worn while continuing to practice physical distancing.* ***Note:*** *It’s critical to reserve surgical masks and N95 respirators for healthcare workers.* [Vaccines and treatment options](https://www.healthline.com/health-news/heres-exactly-where-were-at-with-vaccines-and-treatments-for-covid-19) for COVID-19 are currently being investigated around the world. However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19. Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available. Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms. ### Chloroquine Chloroquine is a drug that’s used to fight malaria and autoimmune diseases. It’s been in use for more than 70 years and is generally considered safe. At the beginning of the pandemic, [researchers](https://www.nature.com/articles/s41422-020-0282-0) discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies. However, a [February 2021 literature review](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full) concluded that there wasn’t enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquine’s role as a COVID-19 treatment. ### Lopinavir and ritonavir Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV. In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a [significant reduction](https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79) in his levels of the coronavirus. Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs. According to a [February 2021 study](https://www.nejm.org/doi/full/10.1056/NEJMoa2023184) published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didn’t definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays. ### Favilavir (favipiravir) In February 2020, China [approved](https://www.upi.com/Health_News/2020/02/17/China-approves-antiviral-favilavir-to-treat-coronavirus/5291581953892) the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. It’s also commonly known as favipiravir. The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people. A [January 2021 study](https://pubs.acs.org/doi/full/10.1021/acscentsci.0c01242) in ACS Central Science concluded that favilavir and the antiviral drug ribavirin weren’t as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA. ## [What should you do if you think you have COVID-19 symptoms?]() Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, they’re usually mild and tend to come on slowly. COVID-19 seems to cause more severe symptoms in [older adults](https://www.healthline.com/health/coronavirus-tips-and-advice-for-older-adults) and people with underlying health conditions, such as chronic heart or lung conditions. If you think you have symptoms of COVID-19, follow this protocol: 1. **Call the doctor.** If you have [mild symptoms](https://www.healthline.com/health/mild-covid-symptoms), call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested. 2. **Stay home.** If you have symptoms of COVID-19 or another type of [viral infection](https://www.healthline.com/health/bacterial-vs-viral-infections), stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones. COVID-19 is so common now that exposure is likely. If you’re feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating). You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19. ## [When do you need medical care?]() [About 80 percent](https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19) of people recover from COVID-19 without needing hospitalization or special treatment. If you’re young and healthy and experience only mild symptoms, a doctor will likely advise you to [isolate yourself at home](https://www.healthline.com/health/do-you-have-to-quarantine-if-you-have-been-vaccinated) and limit contact with others in your household. You’ll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely. If you’re an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action. If your symptoms worsen despite home care, it’s important to get prompt medical care. The symptoms that indicate a medical emergency are: - having trouble breathing - blue lips or a blue face - persistent chest pain or pressure in the chest - confusion - severe drowsiness Call the local hospital, clinic, or urgent care to let them know you’ll be coming in, and wear a [face mask](https://www.healthline.com/health/best-face-masks-covid-specific) once you leave your home. You can also call 911 or your local emergency services for immediate medical attention. ## [How can you avoid infection with the novel coronavirus?]() The novel coronavirus is primarily [transmitted from person to person](https://www.healthline.com/health/coronavirus-transmission). At this point, the best way to prevent infection is to avoid being around people who’ve been exposed to the virus. Also, according to the [CDC](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html), you can take the following precautions to lower your risk of infection: - **Wash your hands** thoroughly [with soap and water](https://www.healthline.com/health/7-steps-of-handwashing) for at least 20 seconds. - **Use hand sanitizer** with at least 60 percent alcohol if soap isn’t available. - **Avoid touching your face** unless you’ve recently washed your hands. - **Stay clear of people** who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick. - **Avoid crowded areas** as much as possible. Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus. ## [What’s the bottom line?]() Researchers around the world are working hard to develop potential [vaccines](https://www.healthline.com/health-news/cdc-finds-covid-19-vaccines-safe-after-22-million-vaccinations) and treatments. Get vaccinated [as soon as you’re eligible](https://www.healthline.com/coronavirus). At the moment, the FDA has approved only one drug — remdesivir (Veklury) — for the treatment of COVID-19. A few drugs have received EUAs, though. There’s little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective. ### How we reviewed this article: Sources History Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.healthline.com/about/process). - Beigel JH, et al. (2020). Remdesivir for the treatment of COVID-19 — Final report. <https://www.nejm.org/doi/full/10.1056/NEJMoa2007764> - BylĂ©hn F, et al. (2021). Modeling the binding mechanism of remdesivir, favilavir, and ribavirin to SARS-COV-2 RNA-dependent RNA polymerase. <https://pubs.acs.org/doi/full/10.1021/acscentsci.0c01242> - Coronavirus disease (COVID-19). (2020). [https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.who.int%2Fnews-room%2Fq-a-detail%2Fq-a-coronaviruses\&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705601445\&sdata=3tY8st0eN%2B6hYhX2iRNHyrxd%2BKeZoqbDj9ovpCaMlMk%3D\&reserved=0](https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.who.int%2Fnews-room%2Fq-a-detail%2Fq-a-coronaviruses&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705601445&sdata=3tY8st0eN%2B6hYhX2iRNHyrxd%2BKeZoqbDj9ovpCaMlMk%3D&reserved=0) - Coronavirus resource center. (2021). <https://www.health.harvard.edu/diseases-and-conditions/coronavirus-resource-center> - COVID-19 dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). (2021). <https://coronavirus.jhu.edu/map.html> - Emergency use authorization. (2021). <https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/emergency-use-authorization> - Food and Drug Administration (FDA). (2020). FDA’s approval of Veklury (remdesivir) for the treatment of COVID-19—The science of safety and effectiveness. <https://www.fda.gov/drugs/drug-safety-and-availability/fdas-approval-veklury-remdesivir-treatment-covid-19-science-safety-and-effectiveness> - Food and Drug Administration (FDA). (2021). Coronavirus (COVID-19) update: FDA authorizes monoclonal antibodies for treatment of COVID-19 \[Press release\]. <https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-monoclonal-antibodies-treatment-covid-19-0> - How to protect yourself & others. (2020). <https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html> - Interim clinical guidance for management of patients with confirmed coronavirus disease (COVID-19). (2021). [https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Fclinical-guidance-management-patients.html\&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705576558\&sdata=fvdGtjUz1MqqT9nA5G1iHRoCMTAUjjF0eiACm%2FiJ9go%3D\&reserved=0](https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Fclinical-guidance-management-patients.html&data=02%7C01%7Ccbrocato%40healthline.com%7C3ea75ca642c543c7413c08d7c66e9ccc%7C4289d6102cfd46218c9644a1518ddb0a%7C0%7C0%7C637196050705576558&sdata=fvdGtjUz1MqqT9nA5G1iHRoCMTAUjjF0eiACm%2FiJ9go%3D&reserved=0) - Investigational COVID-19 convalescent plasma: Guidance for industry. (2021). <https://www.fda.gov/media/136798/download> - Libster R, et al. (2021). Early high-titer plasma therapy to prevent severe COVID-19 in older adults. <https://www.nejm.org/doi/10.1056/NEJMoa2033700> - Lim J, et al. (2020). Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: The application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR. <https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79> - Singh B, et al. (2021). Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19. <https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full> - Symptoms of coronavirus. (2020). <https://www.cdc.gov/coronavirus/2019-ncov/symptoms-testing/symptoms.html> - Updated guidance on evaluating and testing persons for coronavirus disease 2019 (COVID-19). (2020). <https://emergency.cdc.gov/han/2020/han00429.asp> - Wang M, et al. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. <https://www.nature.com/articles/s41422-020-0282-0> - WHO Solidarity Trial Consortium. (2021). Repurposed antiviral drugs for COVID-19 — Interim WHO Solidarity Trial results. <https://www.nejm.org/doi/full/10.1056/NEJMoa2023184> Share this article ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2022/01/Joseph-Vinetz-500x500-Bio.png?w=105&h=105) [Medically reviewed]() by [Joseph Vinetz, MD]() — Written by [Daniel Yetman]() — [Updated on February 18, 2021]() ## related stories - [Everything You Should Know About COVID-19 in 2024](https://www.healthline.com/health/coronavirus-covid-19?utm_source=ReadNext) - [How Does the Coronavirus and COVID-19 Spread?](https://www.healthline.com/health/coronavirus-transmission?utm_source=ReadNext) - [How to Prepare for a COVID-19 Vaccine Appointment](https://www.healthline.com/health/how-to-prepare-for-covid-vaccine?utm_source=ReadNext) - [FDA OKs New Drug To Boost COVID-19 Protection for Immunocompromised People](https://www.healthline.com/health-news/fda-oks-new-drug-to-boost-covid-19-protection-for-immunocompromised-people?utm_source=ReadNext) - [What to Know About COVID-19 Bivalent Vaccines](https://www.healthline.com/health/vaccinations/what-is-bivalent-vaccine?utm_source=ReadNext) ### Read this next - [Everything You Should Know About COVID-19 in 2024](https://www.healthline.com/health/coronavirus-covid-19?utm_source=ReadNext) [Get the facts about the 2019 coronavirus (and COVID-19). Discover symptoms, risk factors, tips to prevent contracting and transmitting it, and more.](https://www.healthline.com/health/coronavirus-covid-19?utm_source=ReadNext) [READ MORE](https://www.healthline.com/health/coronavirus-covid-19?utm_source=ReadNext) - [How Does the Coronavirus and COVID-19 Spread?](https://www.healthline.com/health/coronavirus-transmission?utm_source=ReadNext) [Person-to-person contact is the main method of transmission of the new coronavirus. This happens through respiratory droplets from an infected person
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Readable Markdown
COVID-19 is an infectious disease caused by SARS-CoV-2, the novel coronavirus. The novel coronavirus was discovered after an outbreak in Wuhan, China, in December 2019. Since the initial outbreak, the novel coronavirus has spread to most countries around the world. It’s been responsible for [tens of millions of infections](https://coronavirus.jhu.edu/map.html) globally, causing well over 2 million deaths. The United States is the most affected country. Vaccines are now available to protect against the novel coronavirus. Researchers are also working on creating more potential treatments for COVID-19. The disease is more likely to cause symptoms in older adults and those with underlying health conditions. Most people who develop [symptoms of COVID-19](https://www.healthline.com/health/coronavirus-symptoms) experience: - [fever](https://www.healthline.com/health/fever) - [cough](https://www.healthline.com/health/how-long-does-a-cough-last) - [shortness of breath](https://www.healthline.com/health/coronavirus-shortness-of-breath) - [fatigue](https://www.healthline.com/health/fatigue) Less common symptoms include: - [chills](https://www.healthline.com/health/chills), with or without repeated shaking - [headache](https://www.healthline.com/health/is-headache-a-sign-of-coronavirus) - [loss of taste or smell](https://www.healthline.com/health/coronavirus-loss-of-taste-loss-of-smell) - [sore throat](https://www.healthline.com/health/sore-throat-coronavirus) - [muscle aches and pains](https://www.healthline.com/health/muscle-aches) - a stuffy or runny nose - [diarrhea, nausea, vomiting, and other gastrointestinal symptoms](https://www.healthline.com/health/coronavirus-diarrhea) - discolored fingers or [toes](https://www.healthline.com/health/covid-toe-rash) - [pink eye](https://www.healthline.com/health/coronavirus-pink-eye) Keep reading to learn more about the current treatment options for COVID-19, what types of treatments are being explored, and what to do if you develop symptoms. > **HEALTHLINE’S CORONAVIRUS COVERAGE** > > Stay informed with our [live updates](https://www.healthline.com/health-news/coronavirus-live-updates) about the current COVID-19 outbreak. > > Also, visit our [coronavirus hub](https://www.healthline.com/coronavirus) for more information on how to prepare, advice on prevention and treatment, and expert recommendations. Remdesivir (Veklury) is a broad-spectrum antiviral drug originally designed to target Ebola. [Researchers](https://www.nejm.org/doi/full/10.1056/NEJMoa2007764) have found that remdesivir is modestly effective at fighting the novel coronavirus in isolated cells. This intravenous (IV) infusion therapy is used to treat people 12 years old and older who’ve been hospitalized with the condition. To date, it’s still the only COVID-19 treatment that’s been approved by the FDA. Authorized treatments EUAs allow products that haven’t received FDA approval to be used in circumstances where there are no suitable FDA-approved alternatives. The COVID-19 medications that have received EUAs are: - bamlanivimab - a combination of bamlanivimab and etesevimab (etesevimab must be administered in combination with bamlanivimab) - casirivimab and imdevimab, which must be administered together - the oral medication baricitinib (Olumiant), which must be administered with remdesivir - [COVID-19 convalescent plasma](https://www.healthline.com/health-news/why-the-fda-approval-of-convalescent-plasma-is-controversial) - Fresenius Kabi Propoven 2%, an IV sedative - Fresenius Medical, multiFiltrate PRO System and multiBic/multiPlus solutions for people who need continuous renal replacement therapy (CRRT) - REGIOCIT replacement solution with citrate for people who need CRRT Remdesivir has also received an EUA to treat children who are under 12 years old or have a low body weight. Bamlanivimab, etesevimab, casirivimab, and imdevimab are IV infusion therapies. Unlike remdesivir, they’re administered as outpatient therapy and intended for people who have less severe disease. Their purpose is to help reduce the risk of hospitalization. The other medications are all intended for people who’ve been hospitalized or are at risk for hospitalization. A [January 2021 study](https://www.nejm.org/doi/10.1056/NEJMoa2033700) on convalescent plasma looked at effects on adults age 65 and older who’d tested positive for SARS-CoV-2 and were symptomatic. Researchers found that the group who’d received convalescent plasma within 72 hours of the onset of symptoms were 48 percent less likely to develop COVID-19 than the group who’d received a placebo. Convalescent plasma must be administered early into the onset of symptoms to be effective. In February 2021, the [FDA](https://www.fda.gov/media/136798/download) updated its guidance on the use of convalescent plasma. It stated that convalescent plasma must also test as high titer (which means high concentration) before it should be used. Other treatments If your symptoms are more severe, supportive treatments may be given by your doctor or at a hospital. This type of treatment may involve: - fluids to reduce the risk of [dehydration](https://www.healthline.com/health/how-to-tell-if-youre-dehydrated) - medication to reduce a fever - [supplemental oxygen](https://www.healthline.com/health/oxygen-therapy) in more severe cases People who have a hard time breathing due to COVID-19 may need a [ventilator](https://www.healthline.com/health/ventilator). Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. [Learn more.](https://www.healthline.com/about/brand-and-product-vetting) However, none of the experimental medications has proven to be effective thus far concerning preventing illness or treating the symptoms of COVID-19. Researchers will need to perform more randomized controlled trials in humans before additional effective treatments become available. Here are some of the treatment options that have been investigated for protection against SARS-CoV-2 and treatment of COVID-19 symptoms. Chloroquine Chloroquine is a drug that’s used to fight malaria and autoimmune diseases. It’s been in use for more than 70 years and is generally considered safe. At the beginning of the pandemic, [researchers](https://www.nature.com/articles/s41422-020-0282-0) discovered that the drug effectively fought the SARS-CoV-2 virus in test tube studies. However, a [February 2021 literature review](https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013587.pub2/full) concluded that there wasn’t enough evidence to deem it effective. The authors of the review also suggested that researchers end clinical trials examining chloroquine’s role as a COVID-19 treatment. Lopinavir and ritonavir Lopinavir and ritonavir are sold under the name Kaletra and are designed to treat HIV. In early 2020, a 54-year-old South Korean man was given a combination of these two drugs and had a [significant reduction](https://jkms.org/DOIx.php?id=10.3346/jkms.2020.35.e79) in his levels of the coronavirus. Afterward, the World Health Organization (WHO) suggested that there may be benefits to using Kaletra in combination with other drugs. According to a [February 2021 study](https://www.nejm.org/doi/full/10.1056/NEJMoa2023184) published in the New England Journal of Medicine and conducted by the WHO and its partners, this drug combination has little to no effect on people hospitalized with COVID-19. Taking the medication didn’t definitively decrease mortality rates, ventilation rates, or the duration of their hospital stays. Favilavir (favipiravir) In February 2020, China [approved](https://www.upi.com/Health_News/2020/02/17/China-approves-antiviral-favilavir-to-treat-coronavirus/5291581953892) the use of the antiviral drug favilavir to treat symptoms of COVID-19. The drug was initially developed to treat inflammation in the nose and throat. It’s also commonly known as favipiravir. The early word was that the drug was shown to be effective in treating COVID-19 symptoms in a clinical trial of 70 people. A [January 2021 study](https://pubs.acs.org/doi/full/10.1021/acscentsci.0c01242) in ACS Central Science concluded that favilavir and the antiviral drug ribavirin weren’t as effective as remdesivir. Despite its early approval in China, favilavir has yet to be authorized or approved by the FDA. Not everyone with a SARS-CoV-2 infection will feel ill. Some people may even contract the virus and not develop symptoms. When there are symptoms, they’re usually mild and tend to come on slowly. COVID-19 seems to cause more severe symptoms in [older adults](https://www.healthline.com/health/coronavirus-tips-and-advice-for-older-adults) and people with underlying health conditions, such as chronic heart or lung conditions. If you think you have symptoms of COVID-19, follow this protocol: 1. **Call the doctor.** If you have [mild symptoms](https://www.healthline.com/health/mild-covid-symptoms), call a doctor. To reduce transmission of the virus, many clinics encourage people to call or use a live chat function instead of going into a clinic. A doctor will evaluate your symptoms and work with local health authorities and the Centers for Disease Control and Prevention (CDC) to determine if you need to be tested. 2. **Stay home.** If you have symptoms of COVID-19 or another type of [viral infection](https://www.healthline.com/health/bacterial-vs-viral-infections), stay home and get plenty of rest. Be sure to stay away from other people and avoid sharing items such as drinking glasses, utensils, keyboards, and phones. COVID-19 is so common now that exposure is likely. If you’re feeling sick, assume that you may have COVID-19 and be sure to follow public health guidance (such as wearing a mask and isolating). You should also take any medications that your doctor eventually recommends or prescribes. A growing number of effective treatments are available to help address the symptoms of COVID-19. [About 80 percent](https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19) of people recover from COVID-19 without needing hospitalization or special treatment. If you’re young and healthy and experience only mild symptoms, a doctor will likely advise you to [isolate yourself at home](https://www.healthline.com/health/do-you-have-to-quarantine-if-you-have-been-vaccinated) and limit contact with others in your household. You’ll likely be advised to rest, stay well hydrated, and to monitor your symptoms closely. If you’re an older adult, have any underlying health conditions, or have a compromised immune system, be sure to contact a doctor as soon as you notice symptoms. A doctor will advise you on the best course of action. If your symptoms worsen despite home care, it’s important to get prompt medical care. The symptoms that indicate a medical emergency are: - having trouble breathing - blue lips or a blue face - persistent chest pain or pressure in the chest - confusion - severe drowsiness Call the local hospital, clinic, or urgent care to let them know you’ll be coming in, and wear a [face mask](https://www.healthline.com/health/best-face-masks-covid-specific) once you leave your home. You can also call 911 or your local emergency services for immediate medical attention. The novel coronavirus is primarily [transmitted from person to person](https://www.healthline.com/health/coronavirus-transmission). At this point, the best way to prevent infection is to avoid being around people who’ve been exposed to the virus. Also, according to the [CDC](https://www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/prevention.html), you can take the following precautions to lower your risk of infection: - **Wash your hands** thoroughly [with soap and water](https://www.healthline.com/health/7-steps-of-handwashing) for at least 20 seconds. - **Use hand sanitizer** with at least 60 percent alcohol if soap isn’t available. - **Avoid touching your face** unless you’ve recently washed your hands. - **Stay clear of people** who are coughing and sneezing. The CDC recommends standing at least 6 feet away from anyone who appears to be sick. - **Avoid crowded areas** as much as possible. Older adults are at the highest risk of infection and may want to take extra precautions to avoid coming into contact with the virus. At the moment, the FDA has approved only one drug — remdesivir (Veklury) — for the treatment of COVID-19. A few drugs have received EUAs, though. There’s little to no evidence that other unapproved or unauthorized medications have the potential to treat COVID-19 symptoms. More large-scale testing is needed to determine which additional treatments are also safe and effective.
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