🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 98 (from laksa084)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa098.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.healthline.com/health/antidepressant-side-effects\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.healthline.com/health/antidepressant-side-effects\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.healthline.com\/health\/antidepressant-side-effects","crawl_time":1769009538,"first_indexed_time":1545246506,"http_code":200,"src_unparsed":"com,healthline!www,\/health\/antidepressant-side-effects s443","src_root_hash":"11478817528691466898","history_drop_reason":null,"meta_title":"Antidepressant Side Effects: Types, Comparison Chart, and Suicide Risk","meta_descriptions":["Antidepressant side effects can range from mild discomfort to severe impacts on your daily life. We’ll go over and compare the common side effects associated with different types of antidepressants."],"attrs_boilerpipe_text":"There are different types of antidepressants, based on how they work within the brain. Some are better for treating certain conditions and symptoms. But they all come with potential side effects.\nGenerally, each type causes somewhat different side effects, but there can still be some variance within a single type.\nPeople can also respond differently to antidepressants. Some people may have no troubling side effects, while others may have one or more serious side effects. This is why you may need to try a few different medications before you find the right fit.\nHere’s a look at the main types of antidepressants and some of the side effects commonly associated with them. If you take a certain type, you probably won’t experience all of the side effects associated with it. You might also experience other side effects, including some serious ones, that aren’t listed here.\nSSRIs\naffect serotonin, which is a neurotransmitter that plays a role in many things, including your mood. Neurotransmitters act as chemical messengers within your body.\nWhen your brain releases serotonin, some of it is used to communicate with other cells, and some of it goes back into the cell that released it. SSRIs decrease the amount of serotonin that goes back into the cell that released it, leaving more available in your brain to communicate with other cells.\nExperts aren’t completely sure about the role serotonin plays in depression. But many believe that low levels of serotonin are a contributing factor.\nSSRI antidepressants include:\ncitalopram\n(Celexa)\nescitalopram\n(Lexapro)\nparoxetine\n(Brisdelle, Paxil, Pexeva)\nfluoxetine\n(Prozac)\nfluvoxamine\nsertraline\n(Zoloft)\nSSRIs are the most common choice for treating MDD, but they can also help with:\ngeneralized anxiety disorder\npanic disorder\nsocial anxiety\ndisorder\npremenstrual dysphoric disorder\npost-traumatic\nstress disorder\nobsessive-compulsive\npersonality disorder\nhot flashes\nCommon side effects\nThe more common side effects of SSRIs include:\nheadaches\nnausea\ntrouble sleeping\ndizziness\ndiarrhea\nweakness and fatigue\nanxiety\nstomach upset\ndry mouth\nsexual problems such as low sex drive, erectile\ndysfunction, or ejaculation problems\nSSRIs are more likely than some antidepressants to cause sexual side effects. They can also increase appetite, potentially leading to weight gain.\nLike SSRIs,\nSNRIs\nare often used to treat MDD. Similar to SSRIs, SNRIs prevent cells in your brain from reabsorbing certain neurotransmitters. This leaves more of them available to communicate with other cells.\nIn the case of SNRIs, the neurotransmitters affected are serotonin and norepinephrine.\nSNRI antidepressants include:\ndesvenlafaxine\n(Khedezla, Pristiq)\nduloxetine\n(Cymbalta)\nlevomilnacipran (Fetzima)\nmilnacipran (Savella)\nvenlafaxine (Effexor XR)\nSNRIs are often used to treat depression, but they can also help with:\nnerve\ndamage caused by diabetes\nfibromyalgia\ngeneralized anxiety disorder\nhot flashes\nCommon side effects\nThe more common side effects of SNRIs include:\nheadaches\nnausea\ninsomnia\ndrowsiness\ndry mouth\ndizziness\nloss of appetite\nconstipation\nsexual problems such as low sex drive, erectile\ndysfunction, or ejaculation problems\nweakness and fatigue\nsweating\nSNRIs can cause sexual side effects, but not as often as SSRIs. Some people who take SNRIs may also gain weight, but weight loss is more common.\nIn some cases, people taking SNRIs may notice increased blood pressure.\nTCAs\nare an older group of antidepressants. Like SNRIs, they help to increase levels of norepinephrine and serotonin your brain. But they also decrease the effects of another neurotransmitter called acetylcholine.\nThis impact on acetylcholine increases the risk of certain side effects. As a result, TCAs are typically only used if SSRIs and SNRIs don’t work well for you.\nSome common TCAs include:\namitriptyline\n(Elavil)\nclomipramine\n(Anafranil)\ndesipramine\n(Norpramin)\ndoxepin\nimipramine\n(Tofranil)\nnortriptyline\n(Pamelor)\nIn addition to treating depression, many TCAs are used for other conditions, including:\nnerve pain\ncaused by shingles\nnerve damage caused by diabetes\nsocial anxiety disorder\nfibromyalgia\nmigraine headache\nbedwetting in children\nCommon side effects\nThe more common side effects of TCAs include:\nheadaches\ndry mouth\nblurred vision\ndigestive issues, such as stomach upset, nausea,\nand constipation\ndizziness\ndrowsiness\ntrouble sleeping\nmemory problems\nfatigue\nweight gain\nsexual problems such as low sex drive, erectile\ndysfunction, or ejaculation problems\ntrouble urinating\nfast heart rate\nsweating\nThe side effects of TCAs are similar to those of SSRIs and SNRIs, but they tend to occur more frequently and can be more bothersome.\nTCAs are also much more likely to cause certain side effects, including:\ndry mouth\nblurred vision\nconstipation\ntrouble urinating\nweight gain\ndrowsiness\nIn rare cases, TCAs can also cause potentially dangerous heart-related side effects, such as:\nlow blood pressure when standing up\nhigh blood pressure\nabnormal heart rate or arrhythmia\nLike TCAs,\nMAOIs\nare an older group of medications. Today, they’re not commonly used for depression, but your healthcare provider might suggest them if others aren’t offering relief.\nMAOIs work by preventing your body from breaking down certain neurotransmitters. This causes an increase in your levels of serotonin, norepinephrine, and dopamine.\nSome common MAOIs include:\nisocarboxazid (Marplan)\nphenelzine (Nardil)\ntranylcypromine (Parnate)\nselegiline (Eldepryl, Emsam)\nIn addition to depression, some MAOIs are used for other conditions. Phenelzine and tranylcypromine are sometimes used for panic disorder and social anxiety. Selegiline is used for Parkinson’s disease.\nCommon side effects\nThe more common side effects of MAOIs include:\nlow blood pressure\nnausea\nheadaches\ndrowsiness\ndizziness\ndry mouth\nweight gain\nstomach pain\nconfusion\ndiarrhea\nrunny nose\nsexual problems such as low sex drive, erectile\ndysfunction, or ejaculation problems\nMAOIs are more likely to cause low blood pressure than other antidepressants. These medications can also interact with\nfoods containing tyramine\nand cause dangerously high blood pressure.\nSARIs are also known as serotonin modulators or phenylpiperazine antidepressants. They’re sometimes considered atypical antidepressants because they work differently. SARIs can help treat:\ndepression\nanxiety\npanic disorder\nLike most other antidepressants, SARIs help to increase the amount of available serotonin — and sometimes other neurotransmitters — in your brain. But they do so in different ways from other antidepressants.\nSome SARIs include:\nnefazodone\ntrazodone\n(Oleptro)\nCommon side effects\nThe more common side effects of SARIs include:\ndrowsiness\ndry mouth\nheadaches\ndizziness\nnausea\nfatigue\nvomiting\nblurred vision\ndiarrhea\nconstipation\nlow blood pressure\nconfusion\nMany people taking SARIs experience drowsiness or sleepiness. This makes them a potentially good option for people with insomnia, especially if they also have depression.\nSome antidepressants simply don’t fit into any of the main group, usually because of the way they work. These are known as atypical antidepressants.\nBupropion (Wellbutrin)\nUnlike most other antidepressants,\nbupropion\ndoesn’t increase serotonin. Instead, it works to increase norepinephrine and dopamine. It’s sometimes classified as a norepinephrine-dopamine reuptake inhibitor.\nIn addition to being used for depression, bupropion is also used to help people quit smoking.\nThe more common side effects of bupropion include:\ntrouble sleeping\nheadaches\nirritability or agitation\ndry mouth\nconstipation\nloss of appetite\nweight loss\nnausea\nvomiting\nsweating\ndizziness\nanxiety\nCompared with other antidepressants, bupropion is less likely to cause weight gain. In fact, weight loss is a common side effect.\nBupropion is also less likely to cause sexual problems. As a result, it’s sometimes prescribed alongside other antidepressants to reduce their sexual side effects.\nBut it’s more likely than some other antidepressants to cause insomnia and anxiety. In rare cases, bupropion can cause seizures, especially when used in high doses.\nMirtazapine (Remeron)\nMirtazapine\nincreases the effects of norepinephrine, serotonin, and dopamine in your brain in a different way than other antidepressants. It’s sometimes classified as a noradrenergic antagonist-specific serotonin antagonist.\nThe more common side effects of mirtazapine include:\ndrowsiness\ndry mouth\nincreased appetite\nweight gain\nhigh cholesterol\nconstipation\nweakness and fatigue\ndizziness\nLike SARIs, mirtazapine may cause sleepiness or drowsiness. As a result, mirtazapine may be used for those who have depression and trouble sleeping.\nMirtazapine can also cause increased appetite, making it more likely to cause weight gain than other antidepressants.\nVilazodone (Viibryd)\nVilazodone increases serotonin’s effects in the brain in ways both similar to and different from SSRIs. It’s sometimes called a serotonin partial agonist reuptake inhibitor.\nThe more common side effects of vilazodone include:\ndiarrhea\nnausea\ndizziness\ndry mouth\ntrouble sleeping\nvomiting\nVilazodone is less likely to cause weight gain than many other antidepressants, such as SSRIs and TCAs. Some people who take vilazodone have sexual problems, such as low sex drive or erectile dysfunction, but this seems to be less common with vilazodone compared to SSRIs and SNRIs.\nVortioxetine (Trintellix)\nVortioxetine\nis sometimes called a multimodal antidepressant. It functions somewhat like an SSRI, but has additional effects on serotonin levels.\nThe more common side effects of vortioxetine include:\nsexual problems, such as orgasm or ejaculation\nproblems\nnausea\ndiarrhea\ndizziness\ndry mouth\nconstipation\nvomiting\nVortioxetine is more likely to cause sexual side effects than many other antidepressants. But it’s less likely to cause weight gain.\nThe chart below is a general comparison of the some of the more common side effects associated with different antidepressants.\nWhen using this chart, keep a few things in mind:\nEveryone responds differently to\nantidepressants, so you may have additional side effects not listed here.\nYou likely won’t experience every single side\neffect associated with a particular antidepressant.\nSome medications are more or less likely to\ncause certain side effects. Your healthcare provider can give you more\ninformation about common side effects linked to specific medications within\neach group.\nSome side effects may become milder or disappear\ncompletely over time as your body gets used to the medication.\nThis chart only includes common side effects.\nSome antidepressants may have less common, more serious side effects, including\nincreased suicidal thoughts.\nSide effect\nSSRIs\nSNRIs\nTCAs\nMAOIs\nSARIs\nbupropion\nmirtazapine\nvilazodone\nvortioxetine\nheadache\nX\nX\nX\nX\nX\nX\ndiarrhea\nX\nX\nX\nX\nX\nX\ndry mouth\nX\nX\nX\nX\nX\nX\nX\nX\nX\nfatigue\nX\nX\nX\nX\nX\nX\nX\nsweating\nX\nX\nX\nX\ndizziness\nX\nX\nX\nX\nX\nX\nX\nX\nblurred vision\nX\nX\nX\nsexual issues\nX\nX\nX\nX\nX\nX\ndrowsiness\nX\nX\nX\nX\nX\nX\nX\ninsomnia\nX\nX\nX\nX\nX\nweight gain\nX\nX\nX\nX\nX\nweight loss\nX\nX\nX\nSome antidepressants, including SSRIs, may cause an increase in suicidal thoughts or actions. This risk is higher in children, teenagers, and young adults. It’s also higher within the first few months of treatment or during dosage changes.\nYou and your family members, caregivers, and healthcare provider should watch for any new or sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you notice any changes.\nThere are many types of antidepressants. Each comes with its own list of potential side effects. When choosing and trying an antidepressant, it’s important to work closely with your healthcare provider, especially as you get used to a medication’s side effects.\nBefore starting any new medication, let your healthcare provider know about any other medications you take, including over-the-counter drugs and herbal supplements, such as St. John’s wort. If you drink alcohol, make sure to also ask about any potential interactions it might have with your medication.\nIn addition to side effects, antidepressants can also cause\nallergic reactions\nin some people. Seek immediate medical treatment if you notice any symptoms of a severe allergic reaction, such as difficulty breathing or swelling in your face, tongue, or throat.","attrs_markdown":"- Health Conditions\n  ### Health Conditions\n  [All](https:\/\/www.healthline.com\/directory\/topics)\n  \n  - [Breast Cancer](https:\/\/www.healthline.com\/breast-cancer)\n  - [Cancer Care](https:\/\/www.healthline.com\/cancer-care)\n  - [Caregiving for Alzheimer's Disease](https:\/\/www.healthline.com\/alzheimers-disease)\n  - [Chronic Kidney Disease](https:\/\/www.healthline.com\/ckd)\n  - [Chronic Obstructive Pulmonary Disease (COPD)](https:\/\/www.healthline.com\/copd)\n  - [Digestive Health](https:\/\/www.healthline.com\/digestive-health)\n  - [Eye Health](https:\/\/www.healthline.com\/eye-health)\n  - [Heart Health](https:\/\/www.healthline.com\/heart-health)\n  - [Menopause](https:\/\/www.healthline.com\/menopause)\n  - [Mental Health](https:\/\/www.healthline.com\/mental-health)\n  - [Migraine](https:\/\/www.healthline.com\/migraine)\n  - 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Connect with us for all things health.\n\nSubscribe\n\n[Anxiety and Depression](https:\/\/www.healthline.com\/anxiety-and-depression)\n\n- [Anxiety Treatment](https:\/\/www.healthline.com\/anxiety-and-depression\/anxiety-treatment)\n- [Depression Treatment](https:\/\/www.healthline.com\/anxiety-and-depression\/depression-treatment)\n- [Crisis Support](https:\/\/www.healthline.com\/anxiety-and-depression\/crisis-support)\n- [Navigating Therapy](https:\/\/www.healthline.com\/anxiety-and-depression\/therapy)\n- [Symptoms](https:\/\/www.healthline.com\/anxiety-and-depression\/symptom-management)\n- [Better Sleep](https:\/\/www.healthline.com\/anxiety-and-depression\/sleep-resources)\n- [Nutrition & Supplements](https:\/\/www.healthline.com\/anxiety-and-depression\/nutrition-supplements)\n- [Relationships](https:\/\/www.healthline.com\/anxiety-and-depression\/relationships)\n- [Emotional Well-Being](https:\/\/www.healthline.com\/anxiety-and-depression\/emotional-well-being)\n- [Physical Activity & Exercises](https:\/\/www.healthline.com\/anxiety-and-depression\/physical-activity-exercises)\n- [Resources for Doctors' Visits](https:\/\/www.healthline.com\/anxiety-and-depression\/doctor-guide)\n- [Comorbidities](https:\/\/www.healthline.com\/anxiety-and-depression\/comorbidities)\n\n# A Guide to Common Antidepressant Side Effects\n![](https:\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2018\/09\/adda.png?w=105&h=105)\n\nWritten by [Adda Bjarnadottir, MS, RDN (Ice)]() on December 4, 2018\n\n- [SSRIs](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#ssr-is)\n- [SNRIs](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#snr-is)\n- [TCAs](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#tc-as)\n- [MAOIs](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#mao-is)\n- [SARIs](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#sar-is)\n- [Atypical](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#atypical)\n- [Chart](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#chart)\n- [Suicide risk](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#suicide-risk)\n- [Takeaway](https:\/\/www.healthline.com\/health\/antidepressant-side-effects#takeaway)\n\n## [What are antidepressants?]()\nAntidepressant medications are a first-choice option for treating [major depressive disorder (MDD)](https:\/\/www.healthline.com\/health\/clinical-depression), according to guidelines from the [American Psychiatric Association](https:\/\/psychiatryonline.org\/pb\/assets\/raw\/sitewide\/practice_guidelines\/guidelines\/mdd-guide.pdf). They can also help to treat anxiety conditions, including [generalized anxiety disorder](https:\/\/www.healthline.com\/health\/anxiety\/generalized-anxiety-disorder).\n\nThere are different types of antidepressants, based on how they work within the brain. Some are better for treating certain conditions and symptoms. But they all come with potential side effects.\n\nGenerally, each type causes somewhat different side effects, but there can still be some variance within a single type.\n\nPeople can also respond differently to antidepressants. Some people may have no troubling side effects, while others may have one or more serious side effects. This is why you may need to try a few different medications before you find the right fit.\n\nHere’s a look at the main types of antidepressants and some of the side effects commonly associated with them. If you take a certain type, you probably won’t experience all of the side effects associated with it. You might also experience other side effects, including some serious ones, that aren’t listed here.\n\n## [Selective serotonin reuptake inhibitors (SSRIs)]()\n[SSRIs](https:\/\/www.healthline.com\/health\/depression\/selective-serotonin-reuptake-inhibitors-ssris) affect serotonin, which is a neurotransmitter that plays a role in many things, including your mood. Neurotransmitters act as chemical messengers within your body.\n\nWhen your brain releases serotonin, some of it is used to communicate with other cells, and some of it goes back into the cell that released it. SSRIs decrease the amount of serotonin that goes back into the cell that released it, leaving more available in your brain to communicate with other cells.\n\nExperts aren’t completely sure about the role serotonin plays in depression. But many believe that low levels of serotonin are a contributing factor.\n\nSSRI antidepressants include:\n\n- [citalopram](https:\/\/www.healthline.com\/health\/citalopram-oral-tablet)  \n  (Celexa)\n- [escitalopram](https:\/\/www.healthline.com\/health\/escitalopram-oral-tablet)  \n  (Lexapro)\n- [paroxetine](https:\/\/www.healthline.com\/health\/paroxetine-oral-tablet)  \n  (Brisdelle, Paxil, Pexeva)\n- [fluoxetine](https:\/\/www.healthline.com\/health\/depression\/prozac-lexapro)  \n  (Prozac)\n- [fluvoxamine](https:\/\/www.healthline.com\/health\/fluvoxamine-oral-capsule)\n- [sertraline](https:\/\/www.healthline.com\/health\/sertraline-oral-tablet)  \n  (Zoloft)\n\nSSRIs are the most common choice for treating MDD, but they can also help with:\n\n- generalized anxiety disorder\n- [panic disorder](https:\/\/www.healthline.com\/health\/panic-disorder)\n- [social anxiety disorder](https:\/\/www.healthline.com\/health\/anxiety\/social-phobia)\n- premenstrual dysphoric disorder\n- [post-traumatic stress disorder](https:\/\/www.healthline.com\/health\/post-traumatic-stress-disorder)\n- [obsessive-compulsive personality disorder](https:\/\/www.healthline.com\/health\/obsessive-compulsive-personality-disorder)\n- [hot flashes](https:\/\/www.healthline.com\/health\/menopause\/hot-flash-causes)\n### Common side effects\nThe more common side effects of SSRIs include:\n\n- headaches\n- nausea\n- trouble sleeping\n- dizziness\n- diarrhea\n- weakness and fatigue\n- anxiety\n- stomach upset\n- dry mouth\n- sexual problems such as low sex drive, erectile  \n  dysfunction, or ejaculation problems\n\nSSRIs are more likely than some antidepressants to cause sexual side effects. They can also increase appetite, potentially leading to weight gain.\n\n## [Serotonin-norepinephrine reuptake inhibitors (SNRIs)]()\nLike SSRIs, [SNRIs](https:\/\/www.healthline.com\/health\/depression\/serotonin-norepinephrine-reuptake-inhibitors-snris) are often used to treat MDD. Similar to SSRIs, SNRIs prevent cells in your brain from reabsorbing certain neurotransmitters. This leaves more of them available to communicate with other cells.\n\nIn the case of SNRIs, the neurotransmitters affected are serotonin and norepinephrine.\n\nSNRI antidepressants include:\n\n- [desvenlafaxine](https:\/\/www.healthline.com\/health\/desvenlafaxine-oral-tablet)  \n  (Khedezla, Pristiq)\n- [duloxetine](https:\/\/www.healthline.com\/health\/duloxetine-oral-capsule)  \n  (Cymbalta)\n- levomilnacipran (Fetzima)\n- milnacipran (Savella)\n- venlafaxine (Effexor XR)\n\nSNRIs are often used to treat depression, but they can also help with:\n\n- [nerve damage caused by diabetes](https:\/\/www.healthline.com\/health\/type-2-diabetes\/diabetic-neuropathy)\n- [fibromyalgia](https:\/\/www.healthline.com\/health\/fibromyalgia)\n- generalized anxiety disorder\n- hot flashes\n### Common side effects\nThe more common side effects of SNRIs include:\n\n- headaches\n- nausea\n- insomnia\n- drowsiness\n- dry mouth\n- dizziness\n- loss of appetite\n- constipation\n- sexual problems such as low sex drive, erectile  \n  dysfunction, or ejaculation problems\n- weakness and fatigue\n- sweating\n\nSNRIs can cause sexual side effects, but not as often as SSRIs. Some people who take SNRIs may also gain weight, but weight loss is more common.\n\nIn some cases, people taking SNRIs may notice increased blood pressure.\n\n## [Tricyclic antidepressants (TCAs)]()\n[TCAs](https:\/\/www.healthline.com\/health\/depression\/tricyclic-antidepressants-tcas) are an older group of antidepressants. Like SNRIs, they help to increase levels of norepinephrine and serotonin your brain. But they also decrease the effects of another neurotransmitter called acetylcholine.\n\nThis impact on acetylcholine increases the risk of certain side effects. As a result, TCAs are typically only used if SSRIs and SNRIs don’t work well for you.\n\nSome common TCAs include:\n\n- [amitriptyline](https:\/\/www.healthline.com\/health\/amitriptyline-oral-tablet)  \n  (Elavil)\n- [clomipramine](https:\/\/www.healthline.com\/health\/clomipramine-oral-capsule)  \n  (Anafranil)\n- [desipramine](https:\/\/www.healthline.com\/health\/desipramine-oral-tablet)  \n  (Norpramin)\n- [doxepin](https:\/\/www.healthline.com\/health\/doxepin-oral-capsule)\n- [imipramine](https:\/\/www.healthline.com\/health\/imipramine-oral-tablet)  \n  (Tofranil)\n- [nortriptyline](https:\/\/www.healthline.com\/health\/nortriptyline-oral-capsule)  \n  (Pamelor)\n\nIn addition to treating depression, many TCAs are used for other conditions, including:\n\n- [nerve pain caused by shingles](https:\/\/www.healthline.com\/health\/postherpetic-neuralgia)\n- nerve damage caused by diabetes\n- social anxiety disorder\n- fibromyalgia\n- migraine headache\n- bedwetting in children\n### Common side effects\nThe more common side effects of TCAs include:\n\n- headaches\n- dry mouth\n- blurred vision\n- digestive issues, such as stomach upset, nausea,  \n  and constipation\n- dizziness\n- drowsiness\n- trouble sleeping\n- memory problems\n- fatigue\n- weight gain\n- sexual problems such as low sex drive, erectile  \n  dysfunction, or ejaculation problems\n- trouble urinating\n- fast heart rate\n- sweating\n\nThe side effects of TCAs are similar to those of SSRIs and SNRIs, but they tend to occur more frequently and can be more bothersome.\n\nTCAs are also much more likely to cause certain side effects, including:\n\n- dry mouth\n- blurred vision\n- constipation\n- trouble urinating\n- weight gain\n- drowsiness\n\nIn rare cases, TCAs can also cause potentially dangerous heart-related side effects, such as:\n\n- low blood pressure when standing up\n- high blood pressure\n- abnormal heart rate or arrhythmia\n\n## [Monoamine oxidase inhibitors (MAOIs)]()\nLike TCAs, [MAOIs](https:\/\/www.healthline.com\/health\/depression\/what-are-mao-inhibitors) are an older group of medications. Today, they’re not commonly used for depression, but your healthcare provider might suggest them if others aren’t offering relief.\n\nMAOIs work by preventing your body from breaking down certain neurotransmitters. This causes an increase in your levels of serotonin, norepinephrine, and dopamine.\n\nSome common MAOIs include:\n\n- isocarboxazid (Marplan)\n- phenelzine (Nardil)\n- tranylcypromine (Parnate)\n- selegiline (Eldepryl, Emsam)\n\nIn addition to depression, some MAOIs are used for other conditions. Phenelzine and tranylcypromine are sometimes used for panic disorder and social anxiety. Selegiline is used for Parkinson’s disease.\n\n### Common side effects\nThe more common side effects of MAOIs include:\n\n- low blood pressure\n- nausea\n- headaches\n- drowsiness\n- dizziness\n- dry mouth\n- weight gain\n- stomach pain\n- confusion\n- diarrhea\n- runny nose\n- sexual problems such as low sex drive, erectile  \n  dysfunction, or ejaculation problems\n\nMAOIs are more likely to cause low blood pressure than other antidepressants. These medications can also interact with [foods containing tyramine](https:\/\/www.healthline.com\/health\/tyramine-free-diets) and cause dangerously high blood pressure.\n\n## [Serotonin antagonist and reuptake inhibitors (SARIs)]()\nSARIs are also known as serotonin modulators or phenylpiperazine antidepressants. They’re sometimes considered atypical antidepressants because they work differently. SARIs can help treat:\n\n- depression\n- anxiety\n- panic disorder\n\nLike most other antidepressants, SARIs help to increase the amount of available serotonin — and sometimes other neurotransmitters — in your brain. But they do so in different ways from other antidepressants.\n\nSome SARIs include:\n\n- nefazodone\n- [trazodone](https:\/\/www.healthline.com\/health\/trazodone-oral-tablet)  \n  (Oleptro)\n### Common side effects\nThe more common side effects of SARIs include:\n\n- drowsiness\n- dry mouth\n- headaches\n- dizziness\n- nausea\n- fatigue\n- vomiting\n- blurred vision\n- diarrhea\n- constipation\n- low blood pressure\n- confusion\n\nMany people taking SARIs experience drowsiness or sleepiness. This makes them a potentially good option for people with insomnia, especially if they also have depression.\n\n## [Atypical antidepressants]()\nSome antidepressants simply don’t fit into any of the main group, usually because of the way they work. These are known as atypical antidepressants.\n\n### Bupropion (Wellbutrin)\nUnlike most other antidepressants, [bupropion](https:\/\/www.healthline.com\/health\/bupropion-oral-tablet) doesn’t increase serotonin. Instead, it works to increase norepinephrine and dopamine. It’s sometimes classified as a norepinephrine-dopamine reuptake inhibitor.\n\nIn addition to being used for depression, bupropion is also used to help people quit smoking.\n\nThe more common side effects of bupropion include:\n\n- trouble sleeping\n- headaches\n- irritability or agitation\n- dry mouth\n- constipation\n- loss of appetite\n- weight loss\n- nausea\n- vomiting\n- sweating\n- dizziness\n- anxiety\n\nCompared with other antidepressants, bupropion is less likely to cause weight gain. In fact, weight loss is a common side effect.\n\nBupropion is also less likely to cause sexual problems. As a result, it’s sometimes prescribed alongside other antidepressants to reduce their sexual side effects.\n\nBut it’s more likely than some other antidepressants to cause insomnia and anxiety. In rare cases, bupropion can cause seizures, especially when used in high doses.\n\n### Mirtazapine (Remeron)\n[Mirtazapine](https:\/\/www.healthline.com\/health\/mirtazapine-oral-tablet) increases the effects of norepinephrine, serotonin, and dopamine in your brain in a different way than other antidepressants. It’s sometimes classified as a noradrenergic antagonist-specific serotonin antagonist.\n\nThe more common side effects of mirtazapine include:\n\n- drowsiness\n- dry mouth\n- increased appetite\n- weight gain\n- high cholesterol\n- constipation\n- weakness and fatigue\n- dizziness\n\nLike SARIs, mirtazapine may cause sleepiness or drowsiness. As a result, mirtazapine may be used for those who have depression and trouble sleeping.\n\nMirtazapine can also cause increased appetite, making it more likely to cause weight gain than other antidepressants.\n\n### Vilazodone (Viibryd)\nVilazodone increases serotonin’s effects in the brain in ways both similar to and different from SSRIs. It’s sometimes called a serotonin partial agonist reuptake inhibitor.\n\nThe more common side effects of vilazodone include:\n\n- diarrhea\n- nausea\n- dizziness\n- dry mouth\n- trouble sleeping\n- vomiting\n\nVilazodone is less likely to cause weight gain than many other antidepressants, such as SSRIs and TCAs. Some people who take vilazodone have sexual problems, such as low sex drive or erectile dysfunction, but this seems to be less common with vilazodone compared to SSRIs and SNRIs.\n\n### Vortioxetine (Trintellix)\n[Vortioxetine](https:\/\/www.healthline.com\/health\/cdi\/trintellix) is sometimes called a multimodal antidepressant. It functions somewhat like an SSRI, but has additional effects on serotonin levels.\n\nThe more common side effects of vortioxetine include:\n\n- sexual problems, such as orgasm or ejaculation  \n  problems\n- nausea\n- diarrhea\n- dizziness\n- dry mouth\n- constipation\n- vomiting\n\nVortioxetine is more likely to cause sexual side effects than many other antidepressants. But it’s less likely to cause weight gain.\n\n## [Side effects comparison chart]()\nThe chart below is a general comparison of the some of the more common side effects associated with different antidepressants.\n\nWhen using this chart, keep a few things in mind:\n\n- Everyone responds differently to  \n  antidepressants, so you may have additional side effects not listed here.\n- You likely won’t experience every single side  \n  effect associated with a particular antidepressant.\n- Some medications are more or less likely to  \n  cause certain side effects. Your healthcare provider can give you more  \n  information about common side effects linked to specific medications within  \n  each group.\n- Some side effects may become milder or disappear  \n  completely over time as your body gets used to the medication.\n- This chart only includes common side effects.  \n  Some antidepressants may have less common, more serious side effects, including  \n  increased suicidal thoughts.\n\n|   |   |   |   |   |   |   |   |   |   |\n|---|---|---|---|---|---|---|---|---|---|\n| **Side effect** | **SSRIs** | **SNRIs** | **TCAs** | **MAOIs** | **SARIs** | **bupropion** | **mirtazapine** | **vilazodone** | **vortioxetine** |\n| headache | X | X | X | X | X | X |   |   |   |\n| diarrhea | X |   |   | X | X | X |   | X | X |\n| dry mouth | X | X | X | X | X | X | X | X | X |\n| fatigue | X | X | X |   | X | X | X | X |   |\n| sweating | X | X | X |   |   | X |   |   |   |\n| dizziness | X | X | X | X |   | X | X | X | X |\n| blurred vision |   |   | X |   | X | X |   |   |   |\n| sexual issues | X | X | X | X |   |   |   | X | X |\n| drowsiness | X | X | X | X | X |   | X | X |   |\n| insomnia | X | X | X |   |   | X |   | X |   |\n| weight gain | X |   | X | X | X |   | X |   |   |\n| weight loss |   | X |   |   | X | X |   |   |   |\n\n## [Suicidal thoughts and behaviors risk]()\nSome antidepressants, including SSRIs, may cause an increase in suicidal thoughts or actions. This risk is higher in children, teenagers, and young adults. It’s also higher within the first few months of treatment or during dosage changes.\n\nYou and your family members, caregivers, and healthcare provider should watch for any new or sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you notice any changes.\n\n### Suicide prevention\nIf you think someone is at immediate risk of self-harm or hurting another person:\n\n- Call 911 or your local emergency number.\n- Stay with the person until help arrives.\n- Remove any guns, knives, medications, or other things that may cause harm.\n- Listen, but don’t judge, argue, threaten, or yell.\n\nIf you or someone you know is considering suicide, get help from a crisis or suicide prevention hotline. Call or text the 988 Suicide and Crisis Lifeline at 988 or use the chat feature at [988Lifeline.org](http:\/\/988lifeline.org\/).\n\n## [The bottom line]()\nThere are many types of antidepressants. Each comes with its own list of potential side effects. When choosing and trying an antidepressant, it’s important to work closely with your healthcare provider, especially as you get used to a medication’s side effects.\n\nBefore starting any new medication, let your healthcare provider know about any other medications you take, including over-the-counter drugs and herbal supplements, such as St. John’s wort. If you drink alcohol, make sure to also ask about any potential interactions it might have with your medication.\n\nIn addition to side effects, antidepressants can also cause [allergic reactions](https:\/\/www.healthline.com\/health\/drug-allergy-symptoms) in some people. Seek immediate medical treatment if you notice any symptoms of a severe allergic reaction, such as difficulty breathing or swelling in your face, tongue, or throat.\n\n### How we reviewed this article:\nSources\n\nHistory\n\nHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https:\/\/www.healthline.com\/about\/process).\n\n- Amitriptyline hydrochloride – amitriptyline hydrochloride tablet, film coated. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd>\n- Armstrong C. (2011). APA releases guideline on treatment of patients with major depressive disorder.  \n  <https:\/\/www.aafp.org\/afp\/2011\/0515\/p1219.html>\n- Celexa – citalopram hydrobromide tablet, film coated. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=4259d9b1-de34-43a4-85a8-41dd214e9177>\n- Clinical practice review for generalized anxiety disorder. (2015).  \n  <https:\/\/adaa.org\/resources-professionals\/practice-guidelines-gad>\n- Desvenlafaxine Extended-release – desvenlafaxine tablet, extended release. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6c63a6af-ad06-453e-9b71-03f46f9599bd>\n- Duloxetine Hydrochloride – duloxetine hydrochloride capsule, delayed release. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b82656d8-e22e-42e5-9b97-887e6d09a68c>\n- Emsam – selegiline patch. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b891bd9f-fdb8-4862-89c5-ecdd700398a3>\n- Fetzima – levomilnacipran hydrochloride capsule, extended release. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=f371258d-91b3-4b6a-ac99-434a1964c3af>\n- Fluvoxamine maleate – fluvoxamine maleate capsule, extended release. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=8bbd7e39-b9ab-4716-9522-aa8c4b92210e>\n- Gale CK, et al. (2013). Generalized anxiety disorder.  \n  <https:\/\/www.aafp.org\/afp\/2013\/0115\/p122.html>\n- Imipramine hydrochloride – imipramine hydrochloride tablet. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2f7d5e7f-79aa-4f3a-b9a6-758d9f3ce74d>\n- Lexapro - escitalopram oxalate tablet, film coated. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=13bb8267-1cab-43e5-acae-55a4d957630a>\n- Marplan – isocarboxazid tablet. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=ac387aa0-3f04-4865-a913-db6ed6f4fdc5>\n- Milnacipran HCL – milnacipran hcl tablet. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=eaa14195-1b9c-423c-9412-d2fe0857e39d>\n- Mirtazapine hemihydrate – mirtazapine hemihydrate powder. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=70a5cc3e-2476-7a9e-e053-2991aa0af9cf>\n- Nefazodone hydrochloride – nefazodone hydrochloride tablet. (2016).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=51ff7db5-aaf9-4c3c-86e6-958ebf16b60f>\n- Nortriptyline hydrochloride – nortriptyline hydrochloride capsules. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=765d726b-fd4b-4ef7-afd7-9e7e9bf8cae6>\n- Parnate – tranylcypromine sulfate tablet, film coated. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b72d8187-dfcc-4ea0-b5e9-c0be95b69a27>\n- Paroxetine – paroxetine hydrochloride hemihydrate tablet, film coated. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=899aee24-bd00-ee0a-669d-f4fbe96ef269>\n- Phenelzine sulfate – phenelzine sulfate tablet. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=40483372-448f-4284-976c-8462ef256661>\n- Prozac – fluoxetine hydrochloride capsule. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=c88f33ed-6dfb-4c5e-bc01-d8e36dd97299>\n- Sanchez C, et al. (2014). Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data. DOI:  \n  <https:\/\/doi.org\/10.1016\/j.pharmthera.2014.07.001>\n- Santarsieri D, et al. (2015). Antidepressant efficacy and side-effect burden: a quick guide for clinicians.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4630974\/>\n- Schwartz TL, et al. (2011). Vilazodone: A brief pharmacological and clinical review of the novel serotonin partial agonist and reuptake inhibitor.  \n  <https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3736894\/>\n- Suicidality in children and adolescents being treated with antidepressant medications. (2018).  \n  <https:\/\/www.fda.gov\/drugs\/drugsafety\/postmarketdrugsafetyinformationforpatientsandproviders\/ucm161679.htm>\n- Trazodone hydrochloride – trazodone hydrochloride tablet. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=71961ab1-951d-1493-f76c-2ff25cca2a85>\n- Treating major depressive disorder. (n.d.).  \n  <https:\/\/psychiatryonline.org\/pb\/assets\/raw\/sitewide\/practice_guidelines\/guidelines\/mdd-guide.pdf>\n- Trintellix – vortioxetine tablet, film coated. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838>\n- Venlafaxine – venlafaxine hydrochloride tablet. (2016).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2>\n- Viibryd – vilazodone hydrochloride tablet. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=4c55ccfb-c4cf-11df-851a-0800200c9a66>\n- Wellbutrin SR – bupropion hydrochloride tablet, film coated. (2017).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=cbc8c074-f080-4489-a5ae-207b5fadeba3>\n- Zisook S, et al. (2006). Use of bupropion in combination with serotonin reuptake inhibitors. DOI:  \n  <https:\/\/doi.org\/10.1016\/j.biopsych.2005.06.027>\n- Zoloft – sertraline hydrochloride tablet, film coated. (2018).  \n  <https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=fe9e8b7d-61ea-409d-84aa-3ebd79a046b5>\n\nShare this article\n\n![](https:\/\/i0.wp.com\/post.healthline.com\/wp-content\/uploads\/2018\/09\/adda.png?w=105&h=105)\n\nWritten by [Adda Bjarnadottir, MS, RDN (Ice)]() on December 4, 2018\n\n## related stories\n- [Managing Antidepressant Sexual Side Effects](https:\/\/www.healthline.com\/health\/erectile-dysfunction\/antidepressant-sexual-side-effects?utm_source=ReadNext)\n- [Can You Overdose on Antidepressants?](https:\/\/www.healthline.com\/health\/can-you-overdose-on-antidepressants?utm_source=ReadNext)\n- [Switching Antidepressants: Charts, Strategies, and More](https:\/\/www.healthline.com\/health\/mdd\/switching-antidepressants?utm_source=ReadNext)\n- [The Dangers of Abruptly Stopping Antidepressants](https:\/\/www.healthline.com\/health\/depression\/dangers-of-stopping-antidepressants?utm_source=ReadNext)\n- [The Power of Glimmers and Joy Lists](https:\/\/www.healthline.com\/health\/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext)\n\n### Read this next\n- [Managing Antidepressant Sexual Side Effects](https:\/\/www.healthline.com\/health\/erectile-dysfunction\/antidepressant-sexual-side-effects?utm_source=ReadNext)\n  \n  Medically reviewed by [Alan Carter, Pharm.D.](https:\/\/www.healthline.com\/medical-team)\n  \n  [Sexual side effects, like erectile dysfunction, are common complaints of taking antidepressants. 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Meta Title	Antidepressant Side Effects: Types, Comparison Chart, and Suicide Risk
Meta Description	Antidepressant side effects can range from mild discomfort to severe impacts on your daily life. We’ll go over and compare the common side effects associated with different types of antidepressants.
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Boilerpipe Text	There are different types of antidepressants, based on how they work within the brain. Some are better for treating certain conditions and symptoms. But they all come with potential side effects. Generally, each type causes somewhat different side effects, but there can still be some variance within a single type. People can also respond differently to antidepressants. Some people may have no troubling side effects, while others may have one or more serious side effects. This is why you may need to try a few different medications before you find the right fit. Here’s a look at the main types of antidepressants and some of the side effects commonly associated with them. If you take a certain type, you probably won’t experience all of the side effects associated with it. You might also experience other side effects, including some serious ones, that aren’t listed here. SSRIs affect serotonin, which is a neurotransmitter that plays a role in many things, including your mood. Neurotransmitters act as chemical messengers within your body. When your brain releases serotonin, some of it is used to communicate with other cells, and some of it goes back into the cell that released it. SSRIs decrease the amount of serotonin that goes back into the cell that released it, leaving more available in your brain to communicate with other cells. Experts aren’t completely sure about the role serotonin plays in depression. But many believe that low levels of serotonin are a contributing factor. SSRI antidepressants include: citalopram (Celexa) escitalopram (Lexapro) paroxetine (Brisdelle, Paxil, Pexeva) fluoxetine (Prozac) fluvoxamine sertraline (Zoloft) SSRIs are the most common choice for treating MDD, but they can also help with: generalized anxiety disorder panic disorder social anxiety disorder premenstrual dysphoric disorder post-traumatic stress disorder obsessive-compulsive personality disorder hot flashes Common side effects The more common side effects of SSRIs include: headaches nausea trouble sleeping dizziness diarrhea weakness and fatigue anxiety stomach upset dry mouth sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems SSRIs are more likely than some antidepressants to cause sexual side effects. They can also increase appetite, potentially leading to weight gain. Like SSRIs, SNRIs are often used to treat MDD. Similar to SSRIs, SNRIs prevent cells in your brain from reabsorbing certain neurotransmitters. This leaves more of them available to communicate with other cells. In the case of SNRIs, the neurotransmitters affected are serotonin and norepinephrine. SNRI antidepressants include: desvenlafaxine (Khedezla, Pristiq) duloxetine (Cymbalta) levomilnacipran (Fetzima) milnacipran (Savella) venlafaxine (Effexor XR) SNRIs are often used to treat depression, but they can also help with: nerve damage caused by diabetes fibromyalgia generalized anxiety disorder hot flashes Common side effects The more common side effects of SNRIs include: headaches nausea insomnia drowsiness dry mouth dizziness loss of appetite constipation sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems weakness and fatigue sweating SNRIs can cause sexual side effects, but not as often as SSRIs. Some people who take SNRIs may also gain weight, but weight loss is more common. In some cases, people taking SNRIs may notice increased blood pressure. TCAs are an older group of antidepressants. Like SNRIs, they help to increase levels of norepinephrine and serotonin your brain. But they also decrease the effects of another neurotransmitter called acetylcholine. This impact on acetylcholine increases the risk of certain side effects. As a result, TCAs are typically only used if SSRIs and SNRIs don’t work well for you. Some common TCAs include: amitriptyline (Elavil) clomipramine (Anafranil) desipramine (Norpramin) doxepin imipramine (Tofranil) nortriptyline (Pamelor) In addition to treating depression, many TCAs are used for other conditions, including: nerve pain caused by shingles nerve damage caused by diabetes social anxiety disorder fibromyalgia migraine headache bedwetting in children Common side effects The more common side effects of TCAs include: headaches dry mouth blurred vision digestive issues, such as stomach upset, nausea, and constipation dizziness drowsiness trouble sleeping memory problems fatigue weight gain sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems trouble urinating fast heart rate sweating The side effects of TCAs are similar to those of SSRIs and SNRIs, but they tend to occur more frequently and can be more bothersome. TCAs are also much more likely to cause certain side effects, including: dry mouth blurred vision constipation trouble urinating weight gain drowsiness In rare cases, TCAs can also cause potentially dangerous heart-related side effects, such as: low blood pressure when standing up high blood pressure abnormal heart rate or arrhythmia Like TCAs, MAOIs are an older group of medications. Today, they’re not commonly used for depression, but your healthcare provider might suggest them if others aren’t offering relief. MAOIs work by preventing your body from breaking down certain neurotransmitters. This causes an increase in your levels of serotonin, norepinephrine, and dopamine. Some common MAOIs include: isocarboxazid (Marplan) phenelzine (Nardil) tranylcypromine (Parnate) selegiline (Eldepryl, Emsam) In addition to depression, some MAOIs are used for other conditions. Phenelzine and tranylcypromine are sometimes used for panic disorder and social anxiety. Selegiline is used for Parkinson’s disease. Common side effects The more common side effects of MAOIs include: low blood pressure nausea headaches drowsiness dizziness dry mouth weight gain stomach pain confusion diarrhea runny nose sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems MAOIs are more likely to cause low blood pressure than other antidepressants. These medications can also interact with foods containing tyramine and cause dangerously high blood pressure. SARIs are also known as serotonin modulators or phenylpiperazine antidepressants. They’re sometimes considered atypical antidepressants because they work differently. SARIs can help treat: depression anxiety panic disorder Like most other antidepressants, SARIs help to increase the amount of available serotonin — and sometimes other neurotransmitters — in your brain. But they do so in different ways from other antidepressants. Some SARIs include: nefazodone trazodone (Oleptro) Common side effects The more common side effects of SARIs include: drowsiness dry mouth headaches dizziness nausea fatigue vomiting blurred vision diarrhea constipation low blood pressure confusion Many people taking SARIs experience drowsiness or sleepiness. This makes them a potentially good option for people with insomnia, especially if they also have depression. Some antidepressants simply don’t fit into any of the main group, usually because of the way they work. These are known as atypical antidepressants. Bupropion (Wellbutrin) Unlike most other antidepressants, bupropion doesn’t increase serotonin. Instead, it works to increase norepinephrine and dopamine. It’s sometimes classified as a norepinephrine-dopamine reuptake inhibitor. In addition to being used for depression, bupropion is also used to help people quit smoking. The more common side effects of bupropion include: trouble sleeping headaches irritability or agitation dry mouth constipation loss of appetite weight loss nausea vomiting sweating dizziness anxiety Compared with other antidepressants, bupropion is less likely to cause weight gain. In fact, weight loss is a common side effect. Bupropion is also less likely to cause sexual problems. As a result, it’s sometimes prescribed alongside other antidepressants to reduce their sexual side effects. But it’s more likely than some other antidepressants to cause insomnia and anxiety. In rare cases, bupropion can cause seizures, especially when used in high doses. Mirtazapine (Remeron) Mirtazapine increases the effects of norepinephrine, serotonin, and dopamine in your brain in a different way than other antidepressants. It’s sometimes classified as a noradrenergic antagonist-specific serotonin antagonist. The more common side effects of mirtazapine include: drowsiness dry mouth increased appetite weight gain high cholesterol constipation weakness and fatigue dizziness Like SARIs, mirtazapine may cause sleepiness or drowsiness. As a result, mirtazapine may be used for those who have depression and trouble sleeping. Mirtazapine can also cause increased appetite, making it more likely to cause weight gain than other antidepressants. Vilazodone (Viibryd) Vilazodone increases serotonin’s effects in the brain in ways both similar to and different from SSRIs. It’s sometimes called a serotonin partial agonist reuptake inhibitor. The more common side effects of vilazodone include: diarrhea nausea dizziness dry mouth trouble sleeping vomiting Vilazodone is less likely to cause weight gain than many other antidepressants, such as SSRIs and TCAs. Some people who take vilazodone have sexual problems, such as low sex drive or erectile dysfunction, but this seems to be less common with vilazodone compared to SSRIs and SNRIs. Vortioxetine (Trintellix) Vortioxetine is sometimes called a multimodal antidepressant. It functions somewhat like an SSRI, but has additional effects on serotonin levels. The more common side effects of vortioxetine include: sexual problems, such as orgasm or ejaculation problems nausea diarrhea dizziness dry mouth constipation vomiting Vortioxetine is more likely to cause sexual side effects than many other antidepressants. But it’s less likely to cause weight gain. The chart below is a general comparison of the some of the more common side effects associated with different antidepressants. When using this chart, keep a few things in mind: Everyone responds differently to antidepressants, so you may have additional side effects not listed here. You likely won’t experience every single side effect associated with a particular antidepressant. Some medications are more or less likely to cause certain side effects. Your healthcare provider can give you more information about common side effects linked to specific medications within each group. Some side effects may become milder or disappear completely over time as your body gets used to the medication. This chart only includes common side effects. Some antidepressants may have less common, more serious side effects, including increased suicidal thoughts. Side effect SSRIs SNRIs TCAs MAOIs SARIs bupropion mirtazapine vilazodone vortioxetine headache X X X X X X diarrhea X X X X X X dry mouth X X X X X X X X X fatigue X X X X X X X sweating X X X X dizziness X X X X X X X X blurred vision X X X sexual issues X X X X X X drowsiness X X X X X X X insomnia X X X X X weight gain X X X X X weight loss X X X Some antidepressants, including SSRIs, may cause an increase in suicidal thoughts or actions. This risk is higher in children, teenagers, and young adults. It’s also higher within the first few months of treatment or during dosage changes. You and your family members, caregivers, and healthcare provider should watch for any new or sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you notice any changes. There are many types of antidepressants. Each comes with its own list of potential side effects. When choosing and trying an antidepressant, it’s important to work closely with your healthcare provider, especially as you get used to a medication’s side effects. Before starting any new medication, let your healthcare provider know about any other medications you take, including over-the-counter drugs and herbal supplements, such as St. John’s wort. If you drink alcohol, make sure to also ask about any potential interactions it might have with your medication. In addition to side effects, antidepressants can also cause allergic reactions in some people. Seek immediate medical treatment if you notice any symptoms of a severe allergic reaction, such as difficulty breathing or swelling in your face, tongue, or throat.
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Subscribe [Anxiety and Depression](https://www.healthline.com/anxiety-and-depression) - [Anxiety Treatment](https://www.healthline.com/anxiety-and-depression/anxiety-treatment) - [Depression Treatment](https://www.healthline.com/anxiety-and-depression/depression-treatment) - [Crisis Support](https://www.healthline.com/anxiety-and-depression/crisis-support) - [Navigating Therapy](https://www.healthline.com/anxiety-and-depression/therapy) - [Symptoms](https://www.healthline.com/anxiety-and-depression/symptom-management) - [Better Sleep](https://www.healthline.com/anxiety-and-depression/sleep-resources) - [Nutrition & Supplements](https://www.healthline.com/anxiety-and-depression/nutrition-supplements) - [Relationships](https://www.healthline.com/anxiety-and-depression/relationships) - [Emotional Well-Being](https://www.healthline.com/anxiety-and-depression/emotional-well-being) - [Physical Activity & Exercises](https://www.healthline.com/anxiety-and-depression/physical-activity-exercises) - [Resources for Doctors' Visits](https://www.healthline.com/anxiety-and-depression/doctor-guide) - [Comorbidities](https://www.healthline.com/anxiety-and-depression/comorbidities) # A Guide to Common Antidepressant Side Effects ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2018/09/adda.png?w=105&h=105) Written by [Adda Bjarnadottir, MS, RDN (Ice)]() on December 4, 2018 - [SSRIs](https://www.healthline.com/health/antidepressant-side-effects#ssr-is) - [SNRIs](https://www.healthline.com/health/antidepressant-side-effects#snr-is) - [TCAs](https://www.healthline.com/health/antidepressant-side-effects#tc-as) - [MAOIs](https://www.healthline.com/health/antidepressant-side-effects#mao-is) - [SARIs](https://www.healthline.com/health/antidepressant-side-effects#sar-is) - [Atypical](https://www.healthline.com/health/antidepressant-side-effects#atypical) - [Chart](https://www.healthline.com/health/antidepressant-side-effects#chart) - [Suicide risk](https://www.healthline.com/health/antidepressant-side-effects#suicide-risk) - [Takeaway](https://www.healthline.com/health/antidepressant-side-effects#takeaway) ## [What are antidepressants?]() Antidepressant medications are a first-choice option for treating [major depressive disorder (MDD)](https://www.healthline.com/health/clinical-depression), according to guidelines from the [American Psychiatric Association](https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd-guide.pdf). They can also help to treat anxiety conditions, including [generalized anxiety disorder](https://www.healthline.com/health/anxiety/generalized-anxiety-disorder). There are different types of antidepressants, based on how they work within the brain. Some are better for treating certain conditions and symptoms. But they all come with potential side effects. Generally, each type causes somewhat different side effects, but there can still be some variance within a single type. People can also respond differently to antidepressants. Some people may have no troubling side effects, while others may have one or more serious side effects. This is why you may need to try a few different medications before you find the right fit. Here’s a look at the main types of antidepressants and some of the side effects commonly associated with them. If you take a certain type, you probably won’t experience all of the side effects associated with it. You might also experience other side effects, including some serious ones, that aren’t listed here. ## [Selective serotonin reuptake inhibitors (SSRIs)]() [SSRIs](https://www.healthline.com/health/depression/selective-serotonin-reuptake-inhibitors-ssris) affect serotonin, which is a neurotransmitter that plays a role in many things, including your mood. Neurotransmitters act as chemical messengers within your body. When your brain releases serotonin, some of it is used to communicate with other cells, and some of it goes back into the cell that released it. SSRIs decrease the amount of serotonin that goes back into the cell that released it, leaving more available in your brain to communicate with other cells. Experts aren’t completely sure about the role serotonin plays in depression. But many believe that low levels of serotonin are a contributing factor. SSRI antidepressants include: - [citalopram](https://www.healthline.com/health/citalopram-oral-tablet) (Celexa) - [escitalopram](https://www.healthline.com/health/escitalopram-oral-tablet) (Lexapro) - [paroxetine](https://www.healthline.com/health/paroxetine-oral-tablet) (Brisdelle, Paxil, Pexeva) - [fluoxetine](https://www.healthline.com/health/depression/prozac-lexapro) (Prozac) - [fluvoxamine](https://www.healthline.com/health/fluvoxamine-oral-capsule) - [sertraline](https://www.healthline.com/health/sertraline-oral-tablet) (Zoloft) SSRIs are the most common choice for treating MDD, but they can also help with: - generalized anxiety disorder - [panic disorder](https://www.healthline.com/health/panic-disorder) - [social anxiety disorder](https://www.healthline.com/health/anxiety/social-phobia) - premenstrual dysphoric disorder - [post-traumatic stress disorder](https://www.healthline.com/health/post-traumatic-stress-disorder) - [obsessive-compulsive personality disorder](https://www.healthline.com/health/obsessive-compulsive-personality-disorder) - [hot flashes](https://www.healthline.com/health/menopause/hot-flash-causes) ### Common side effects The more common side effects of SSRIs include: - headaches - nausea - trouble sleeping - dizziness - diarrhea - weakness and fatigue - anxiety - stomach upset - dry mouth - sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems SSRIs are more likely than some antidepressants to cause sexual side effects. They can also increase appetite, potentially leading to weight gain. ## [Serotonin-norepinephrine reuptake inhibitors (SNRIs)]() Like SSRIs, [SNRIs](https://www.healthline.com/health/depression/serotonin-norepinephrine-reuptake-inhibitors-snris) are often used to treat MDD. Similar to SSRIs, SNRIs prevent cells in your brain from reabsorbing certain neurotransmitters. This leaves more of them available to communicate with other cells. In the case of SNRIs, the neurotransmitters affected are serotonin and norepinephrine. SNRI antidepressants include: - [desvenlafaxine](https://www.healthline.com/health/desvenlafaxine-oral-tablet) (Khedezla, Pristiq) - [duloxetine](https://www.healthline.com/health/duloxetine-oral-capsule) (Cymbalta) - levomilnacipran (Fetzima) - milnacipran (Savella) - venlafaxine (Effexor XR) SNRIs are often used to treat depression, but they can also help with: - [nerve damage caused by diabetes](https://www.healthline.com/health/type-2-diabetes/diabetic-neuropathy) - [fibromyalgia](https://www.healthline.com/health/fibromyalgia) - generalized anxiety disorder - hot flashes ### Common side effects The more common side effects of SNRIs include: - headaches - nausea - insomnia - drowsiness - dry mouth - dizziness - loss of appetite - constipation - sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems - weakness and fatigue - sweating SNRIs can cause sexual side effects, but not as often as SSRIs. Some people who take SNRIs may also gain weight, but weight loss is more common. In some cases, people taking SNRIs may notice increased blood pressure. ## [Tricyclic antidepressants (TCAs)]() [TCAs](https://www.healthline.com/health/depression/tricyclic-antidepressants-tcas) are an older group of antidepressants. Like SNRIs, they help to increase levels of norepinephrine and serotonin your brain. But they also decrease the effects of another neurotransmitter called acetylcholine. This impact on acetylcholine increases the risk of certain side effects. As a result, TCAs are typically only used if SSRIs and SNRIs don’t work well for you. Some common TCAs include: - [amitriptyline](https://www.healthline.com/health/amitriptyline-oral-tablet) (Elavil) - [clomipramine](https://www.healthline.com/health/clomipramine-oral-capsule) (Anafranil) - [desipramine](https://www.healthline.com/health/desipramine-oral-tablet) (Norpramin) - [doxepin](https://www.healthline.com/health/doxepin-oral-capsule) - [imipramine](https://www.healthline.com/health/imipramine-oral-tablet) (Tofranil) - [nortriptyline](https://www.healthline.com/health/nortriptyline-oral-capsule) (Pamelor) In addition to treating depression, many TCAs are used for other conditions, including: - [nerve pain caused by shingles](https://www.healthline.com/health/postherpetic-neuralgia) - nerve damage caused by diabetes - social anxiety disorder - fibromyalgia - migraine headache - bedwetting in children ### Common side effects The more common side effects of TCAs include: - headaches - dry mouth - blurred vision - digestive issues, such as stomach upset, nausea, and constipation - dizziness - drowsiness - trouble sleeping - memory problems - fatigue - weight gain - sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems - trouble urinating - fast heart rate - sweating The side effects of TCAs are similar to those of SSRIs and SNRIs, but they tend to occur more frequently and can be more bothersome. TCAs are also much more likely to cause certain side effects, including: - dry mouth - blurred vision - constipation - trouble urinating - weight gain - drowsiness In rare cases, TCAs can also cause potentially dangerous heart-related side effects, such as: - low blood pressure when standing up - high blood pressure - abnormal heart rate or arrhythmia ## [Monoamine oxidase inhibitors (MAOIs)]() Like TCAs, [MAOIs](https://www.healthline.com/health/depression/what-are-mao-inhibitors) are an older group of medications. Today, they’re not commonly used for depression, but your healthcare provider might suggest them if others aren’t offering relief. MAOIs work by preventing your body from breaking down certain neurotransmitters. This causes an increase in your levels of serotonin, norepinephrine, and dopamine. Some common MAOIs include: - isocarboxazid (Marplan) - phenelzine (Nardil) - tranylcypromine (Parnate) - selegiline (Eldepryl, Emsam) In addition to depression, some MAOIs are used for other conditions. Phenelzine and tranylcypromine are sometimes used for panic disorder and social anxiety. Selegiline is used for Parkinson’s disease. ### Common side effects The more common side effects of MAOIs include: - low blood pressure - nausea - headaches - drowsiness - dizziness - dry mouth - weight gain - stomach pain - confusion - diarrhea - runny nose - sexual problems such as low sex drive, erectile dysfunction, or ejaculation problems MAOIs are more likely to cause low blood pressure than other antidepressants. These medications can also interact with [foods containing tyramine](https://www.healthline.com/health/tyramine-free-diets) and cause dangerously high blood pressure. ## [Serotonin antagonist and reuptake inhibitors (SARIs)]() SARIs are also known as serotonin modulators or phenylpiperazine antidepressants. They’re sometimes considered atypical antidepressants because they work differently. SARIs can help treat: - depression - anxiety - panic disorder Like most other antidepressants, SARIs help to increase the amount of available serotonin — and sometimes other neurotransmitters — in your brain. But they do so in different ways from other antidepressants. Some SARIs include: - nefazodone - [trazodone](https://www.healthline.com/health/trazodone-oral-tablet) (Oleptro) ### Common side effects The more common side effects of SARIs include: - drowsiness - dry mouth - headaches - dizziness - nausea - fatigue - vomiting - blurred vision - diarrhea - constipation - low blood pressure - confusion Many people taking SARIs experience drowsiness or sleepiness. This makes them a potentially good option for people with insomnia, especially if they also have depression. ## [Atypical antidepressants]() Some antidepressants simply don’t fit into any of the main group, usually because of the way they work. These are known as atypical antidepressants. ### Bupropion (Wellbutrin) Unlike most other antidepressants, [bupropion](https://www.healthline.com/health/bupropion-oral-tablet) doesn’t increase serotonin. Instead, it works to increase norepinephrine and dopamine. It’s sometimes classified as a norepinephrine-dopamine reuptake inhibitor. In addition to being used for depression, bupropion is also used to help people quit smoking. The more common side effects of bupropion include: - trouble sleeping - headaches - irritability or agitation - dry mouth - constipation - loss of appetite - weight loss - nausea - vomiting - sweating - dizziness - anxiety Compared with other antidepressants, bupropion is less likely to cause weight gain. In fact, weight loss is a common side effect. Bupropion is also less likely to cause sexual problems. As a result, it’s sometimes prescribed alongside other antidepressants to reduce their sexual side effects. But it’s more likely than some other antidepressants to cause insomnia and anxiety. In rare cases, bupropion can cause seizures, especially when used in high doses. ### Mirtazapine (Remeron) [Mirtazapine](https://www.healthline.com/health/mirtazapine-oral-tablet) increases the effects of norepinephrine, serotonin, and dopamine in your brain in a different way than other antidepressants. It’s sometimes classified as a noradrenergic antagonist-specific serotonin antagonist. The more common side effects of mirtazapine include: - drowsiness - dry mouth - increased appetite - weight gain - high cholesterol - constipation - weakness and fatigue - dizziness Like SARIs, mirtazapine may cause sleepiness or drowsiness. As a result, mirtazapine may be used for those who have depression and trouble sleeping. Mirtazapine can also cause increased appetite, making it more likely to cause weight gain than other antidepressants. ### Vilazodone (Viibryd) Vilazodone increases serotonin’s effects in the brain in ways both similar to and different from SSRIs. It’s sometimes called a serotonin partial agonist reuptake inhibitor. The more common side effects of vilazodone include: - diarrhea - nausea - dizziness - dry mouth - trouble sleeping - vomiting Vilazodone is less likely to cause weight gain than many other antidepressants, such as SSRIs and TCAs. Some people who take vilazodone have sexual problems, such as low sex drive or erectile dysfunction, but this seems to be less common with vilazodone compared to SSRIs and SNRIs. ### Vortioxetine (Trintellix) [Vortioxetine](https://www.healthline.com/health/cdi/trintellix) is sometimes called a multimodal antidepressant. It functions somewhat like an SSRI, but has additional effects on serotonin levels. The more common side effects of vortioxetine include: - sexual problems, such as orgasm or ejaculation problems - nausea - diarrhea - dizziness - dry mouth - constipation - vomiting Vortioxetine is more likely to cause sexual side effects than many other antidepressants. But it’s less likely to cause weight gain. ## [Side effects comparison chart]() The chart below is a general comparison of the some of the more common side effects associated with different antidepressants. When using this chart, keep a few things in mind: - Everyone responds differently to antidepressants, so you may have additional side effects not listed here. - You likely won’t experience every single side effect associated with a particular antidepressant. - Some medications are more or less likely to cause certain side effects. Your healthcare provider can give you more information about common side effects linked to specific medications within each group. - Some side effects may become milder or disappear completely over time as your body gets used to the medication. - This chart only includes common side effects. Some antidepressants may have less common, more serious side effects, including increased suicidal thoughts. \| \| \| \| \| \| \| \| \| \| \| \|---\|---\|---\|---\|---\|---\|---\|---\|---\|---\| \| Side effect \| SSRIs \| SNRIs \| TCAs \| MAOIs \| SARIs \| bupropion \| mirtazapine \| vilazodone \| vortioxetine \| \| headache \| X \| X \| X \| X \| X \| X \| \| \| \| \| diarrhea \| X \| \| \| X \| X \| X \| \| X \| X \| \| dry mouth \| X \| X \| X \| X \| X \| X \| X \| X \| X \| \| fatigue \| X \| X \| X \| \| X \| X \| X \| X \| \| \| sweating \| X \| X \| X \| \| \| X \| \| \| \| \| dizziness \| X \| X \| X \| X \| \| X \| X \| X \| X \| \| blurred vision \| \| \| X \| \| X \| X \| \| \| \| \| sexual issues \| X \| X \| X \| X \| \| \| \| X \| X \| \| drowsiness \| X \| X \| X \| X \| X \| \| X \| X \| \| \| insomnia \| X \| X \| X \| \| \| X \| \| X \| \| \| weight gain \| X \| \| X \| X \| X \| \| X \| \| \| \| weight loss \| \| X \| \| \| X \| X \| \| \| \| ## [Suicidal thoughts and behaviors risk]() Some antidepressants, including SSRIs, may cause an increase in suicidal thoughts or actions. This risk is higher in children, teenagers, and young adults. It’s also higher within the first few months of treatment or during dosage changes. You and your family members, caregivers, and healthcare provider should watch for any new or sudden changes in your mood, behaviors, thoughts, or feelings. Call your healthcare provider right away if you notice any changes. ### Suicide prevention If you think someone is at immediate risk of self-harm or hurting another person: - Call 911 or your local emergency number. - Stay with the person until help arrives. - Remove any guns, knives, medications, or other things that may cause harm. - Listen, but don’t judge, argue, threaten, or yell. If you or someone you know is considering suicide, get help from a crisis or suicide prevention hotline. Call or text the 988 Suicide and Crisis Lifeline at 988 or use the chat feature at [988Lifeline.org](http://988lifeline.org/). ## [The bottom line]() There are many types of antidepressants. Each comes with its own list of potential side effects. When choosing and trying an antidepressant, it’s important to work closely with your healthcare provider, especially as you get used to a medication’s side effects. Before starting any new medication, let your healthcare provider know about any other medications you take, including over-the-counter drugs and herbal supplements, such as St. John’s wort. If you drink alcohol, make sure to also ask about any potential interactions it might have with your medication. In addition to side effects, antidepressants can also cause [allergic reactions](https://www.healthline.com/health/drug-allergy-symptoms) in some people. Seek immediate medical treatment if you notice any symptoms of a severe allergic reaction, such as difficulty breathing or swelling in your face, tongue, or throat. ### How we reviewed this article: Sources History Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our [editorial policy](https://www.healthline.com/about/process). - Amitriptyline hydrochloride – amitriptyline hydrochloride tablet, film coated. (2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1e6d2c80-fbc8-444e-bdd3-6a91fe1b95bd> - Armstrong C. (2011). APA releases guideline on treatment of patients with major depressive disorder. <https://www.aafp.org/afp/2011/0515/p1219.html> - Celexa – citalopram hydrobromide tablet, film coated. 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(2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8bbd7e39-b9ab-4716-9522-aa8c4b92210e> - Gale CK, et al. (2013). Generalized anxiety disorder. <https://www.aafp.org/afp/2013/0115/p122.html> - Imipramine hydrochloride – imipramine hydrochloride tablet. (2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2f7d5e7f-79aa-4f3a-b9a6-758d9f3ce74d> - Lexapro - escitalopram oxalate tablet, film coated. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=13bb8267-1cab-43e5-acae-55a4d957630a> - Marplan – isocarboxazid tablet. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ac387aa0-3f04-4865-a913-db6ed6f4fdc5> - Milnacipran HCL – milnacipran hcl tablet. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=eaa14195-1b9c-423c-9412-d2fe0857e39d> - Mirtazapine hemihydrate – mirtazapine hemihydrate powder. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=70a5cc3e-2476-7a9e-e053-2991aa0af9cf> - Nefazodone hydrochloride – nefazodone hydrochloride tablet. (2016). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=51ff7db5-aaf9-4c3c-86e6-958ebf16b60f> - Nortriptyline hydrochloride – nortriptyline hydrochloride capsules. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=765d726b-fd4b-4ef7-afd7-9e7e9bf8cae6> - Parnate – tranylcypromine sulfate tablet, film coated. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b72d8187-dfcc-4ea0-b5e9-c0be95b69a27> - Paroxetine – paroxetine hydrochloride hemihydrate tablet, film coated. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=899aee24-bd00-ee0a-669d-f4fbe96ef269> - Phenelzine sulfate – phenelzine sulfate tablet. (2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=40483372-448f-4284-976c-8462ef256661> - Prozac – fluoxetine hydrochloride capsule. 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(2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=71961ab1-951d-1493-f76c-2ff25cca2a85> - Treating major depressive disorder. (n.d.). <https://psychiatryonline.org/pb/assets/raw/sitewide/practice_guidelines/guidelines/mdd-guide.pdf> - Trintellix – vortioxetine tablet, film coated. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1a5b68e2-14d0-419d-9ec6-1ca97145e838> - Venlafaxine – venlafaxine hydrochloride tablet. (2016). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b23637e5-d37f-41b5-ba76-fc053e903bc2> - Viibryd – vilazodone hydrochloride tablet. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4c55ccfb-c4cf-11df-851a-0800200c9a66> - Wellbutrin SR – bupropion hydrochloride tablet, film coated. (2017). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cbc8c074-f080-4489-a5ae-207b5fadeba3> - Zisook S, et al. (2006). Use of bupropion in combination with serotonin reuptake inhibitors. DOI: <https://doi.org/10.1016/j.biopsych.2005.06.027> - Zoloft – sertraline hydrochloride tablet, film coated. (2018). <https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fe9e8b7d-61ea-409d-84aa-3ebd79a046b5> Share this article ![](https://i0.wp.com/post.healthline.com/wp-content/uploads/2018/09/adda.png?w=105&h=105) Written by [Adda Bjarnadottir, MS, RDN (Ice)]() on December 4, 2018 ## related stories - [Managing Antidepressant Sexual Side Effects](https://www.healthline.com/health/erectile-dysfunction/antidepressant-sexual-side-effects?utm_source=ReadNext) - [Can You Overdose on Antidepressants?](https://www.healthline.com/health/can-you-overdose-on-antidepressants?utm_source=ReadNext) - [Switching Antidepressants: Charts, Strategies, and More](https://www.healthline.com/health/mdd/switching-antidepressants?utm_source=ReadNext) - [The Dangers of Abruptly Stopping Antidepressants](https://www.healthline.com/health/depression/dangers-of-stopping-antidepressants?utm_source=ReadNext) - [The Power of Glimmers and Joy Lists](https://www.healthline.com/health/the-power-of-glimmers-and-joy-lists?utm_source=ReadNext) ### Read this next - [Managing Antidepressant Sexual Side Effects](https://www.healthline.com/health/erectile-dysfunction/antidepressant-sexual-side-effects?utm_source=ReadNext) Medically reviewed by [Alan Carter, Pharm.D.](https://www.healthline.com/medical-team) [Sexual side effects, like erectile dysfunction, are common complaints of taking antidepressants. 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