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| Meta Title | Antidepressants for Anxiety: Do They Help? - GoodRx |
| Meta Description | Some types of antidepressants, such as SSRIs and SNRIs, can be used to treat anxiety. Learn how these medications help treat anxiety, the side effects, and more. |
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| Boilerpipe Text | Key takeaways:
Generalized anxiety disorder (GAD) is a mental health condition where you feel worried and anxious a lot — to the point where it gets in the way of your daily life.Â
Anxiety can be treated with therapy and medications, including antidepressants.Â
Two of the best types of antidepressant medications for GAD are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
Despite the name, many antidepressants are also FDA approved for other health conditions — not just depression. Antidepressants are used to treat anxiety disorders, eating disorders, certain types of pain, and more.
Generalized anxiety disorder (GAD) is one of the
most common
mental health conditions in the world. In the U.S. alone, over 1 in 20 people will have GAD at some point in their life. And this number seems to be
going up
in recent years. According to the CDC, about
1 in 6 adults
said they had experienced some symptoms of anxiety within the past 2 weeks.Â
With this in mind, there’s a high chance that either you — or a friend or family member — will deal with
anxiety
at some point. But there are many good treatments that can help if anxiety is disrupting your life. And antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best choices.Â
Generalized anxiety disorder
(GAD) is a mental health condition where your fears and worries are hard to control. People with GAD have anxiety almost every day, to the point where it causes problems at work, school, or home.Â
Symptoms of GAD include:
Feeling anxious or worried most of the time
Having a hard time managing your worries
Feeling restless, jittery, or on edge
Getting tired easily
Having a hard time concentrating, or feeling like your mind “goes blank”
Feeling irritable
Having muscle tension
Experiencing difficulty falling asleep or staying asleep, or feeling like sleep isn’t restful
Yes.
Major depression
and GAD are separate disorders, but it’s possible to have them both
at the same time
. They have their own unique symptoms, but both can make it hard to function in daily life. And both can be treated with therapy and/or medications — including antidepressants.Â
Can SSRIs and SNRIs help with anxiety?
Yes. For many people, SSRIs and SNRIs are a great
first-choice treatment
for generalized anxiety. Though they’re technically called “antidepressants,” these medications are also used to treat many different
anxiety disorders
— including GAD.Â
SSRIs and SNRIs used for
GAD
include:
Compare prices and information on the most popular Anxiety medications.
Some of these medications are FDA approved for generalized anxiety, while others are used “
off-label
.”Â
Experts don’t know exactly how SSRIs and SNRIs work for anxiety. They seem to boost the activity of certain chemical messengers (neurotransmitters) in the brain, especially
serotonin
and norepinephrine. These chemicals play a role in anxiety, mood, and general feelings of well-being.  Â
The
main difference
is that SSRIs mostly affect serotonin, while SNRIs affect both serotonin and
norepinephrine. SSRIs and SNRIs also have slightly different side effects, medication interactions, and dosage options.Â
If you’re considering antidepressants, talk with your healthcare provider. They’ll take note of your symptoms and confirm if you have GAD. You and your provider can then work together to decide if it makes sense to try a daily medication for anxiety, like an SSRI or a SSRI.Â
Your provider can also help you understand what other things might be helpful for your anxiety, like
therapy
or
other types of medications
(more on these below). And they can figure out whether any other
health conditions
could be affecting your anxiety, like
diabetes
or
insomnia
.Â
SSRIs and SNRIs for anxiety take
about 1 month
to
start working
. If the medication seems helpful, your provider may suggest you continue taking it for 6 to 12 months.Â
After this time period, some people work with their provider to
taper down and stop
the medication. Other times, it can make sense to continue antidepressants for a longer time. It all depends on your unique symptoms, and whether other things have been helpful for your anxiety, too — like therapy or lifestyle changes. Â
Yes. In fact, about
2 in 3 people
feel more anxious, irritable, and agitated in the first couple weeks after starting an antidepressant. This seems
especially common
in people with major depression, but it can happen with GAD too. Â
These “jittery” feelings usually start to fade after the first week. In some cases, your healthcare provider might prescribe another short-term medication, like a
benzodiazepine
, to help you feel better during these first few weeks.Â
Yes.
Side effects
are possible when taking these medications. Common side effects of SSRIs and SNRIs include fatigue, upset stomach, trouble sleeping, and sexual problems.Â
Keep in mind: If you do have side effects, they often go away within the first few weeks of starting the medication. Sexual side effects, like
erectile dysfunction
or
low libido
, are the most likely to stick around.Â
SSRIs and SNRIs are great first-choice medications for anxiety. But if your anxiety doesn’t get better, or only partially improves, after you start taking medication, your provider might suggest another approach. This could mean switching to another SSRI or SNRI. Or it might mean trying a different type of medication altogether. Â
Other types of medications that can be helpful for anxiety include:
These medications can be prescribed on their own, or they can be used to boost the effectiveness of an SSRI or SNRI.
As mentioned above, benzodiazepines like
lorazepam
(Ativan) can also be used to help treat anxiety. These types of medications are often prescribed just for short-term use, usually to help manage anxiety symptoms while you’re waiting for an SSRI or SNRI to take effect.
Therapy and medications are both great options for treating anxiety. There’s evidence that
cognitive behavioral therapy
(CBT) actually works
just as well
as medication for treating anxiety.Â
So how do you decide? Remember that anxiety treatment doesn’t have a one-size-fits-all approach. The right treatment for you depends on:
Your personal preferences
Whether you have access to therapist
How much a medication will cost
Your symptoms
Whether you have other mental and physical health problems
Many people also choose to do therapy and take medication at the same time. Again, when it comes to anxiety, it’s all about what works best for you.Â
In addition to medication and therapy, there are other things that can
help with your anxiety
. These include:
Exercising
Â
Practicing
mindfulness
, like yoga or meditation
Eating
nutritious foods
Getting enough good-quality
sleep
every night
Cutting down on
alcohol
Certain herbs and supplements may also be helpful, like
cannabidiol
,
chamomile
, and
fish oil
. But be careful: Many over-the-counter products cause side effects and can interfere with other medications you are taking. Talk with your provider about whether these treatments could be right for you.
Researchers are continuing to investigate how and why antidepressants help to improve anxiety. Some
researchers
want to figure out the best length of treatment.
Other researchers
want to know why some people get better when taking SSRIs and SNRIs — and why others don't.Â
Researchers are also looking into newer antidepressants like
Viibryd
, and other new
types of medications
like esketamine (Spravato).
Understanding new brain pathways
may also help scientists explore new treatments.
The bottom line
When it comes to medications for anxiety, antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best tools out there. But other things can help too, like therapy, exercise, and sufficient quality sleep at night.Â
If you’re dealing with anxiety, talk with your healthcare provider. They can help you understand if you have an anxiety disorder and whether an antidepressant may help.Â
Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.
Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology.
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our
editorial guidelines
. |
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Generalized Anxiety Disorder
# Antidepressants for Anxiety: How They Work and What to Expect
[](https://www.goodrx.com/about/bio/sarah-gupta)[](https://www.goodrx.com/about/bio/sophie-vergnaud)
Written by [Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta) \| Reviewed by [Sophie Vergnaud, MD](https://www.goodrx.com/about/bio/sophie-vergnaud)
Updated on November 28, 2023

Prostock-Studio/iStock via Getty Images
[GAD definition](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#gad-definition)[SSRIs and SNRIs for anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#ssris-and-snris-for-anxiety)[Starting treatment for anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#starting-treatment-for-anxiety)[Antidepressant timeline](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#antidepressant-timeline)[Side effects](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#side-effects)[Other medications for anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#other-medications-for-anxiety)[Medication vs. therapy](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#medication-vs--therapy)[Other ways to manage anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#other-ways-to-manage-anxiety)[Emerging research](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#emerging-research)[Bottom line](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#bottom-line)[References](https://www.goodrx.com/conditions/generalized-anxiety-disorder/antidepressant-treatment#references)
## Key takeaways:
- Generalized anxiety disorder (GAD) is a mental health condition where you feel worried and anxious a lot — to the point where it gets in the way of your daily life.
- Anxiety can be treated with therapy and medications, including antidepressants.
- Two of the best types of antidepressant medications for GAD are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
- Despite the name, many antidepressants are also FDA approved for other health conditions — not just depression. Antidepressants are used to treat anxiety disorders, eating disorders, certain types of pain, and more.
Generalized anxiety disorder (GAD) is one of the [most common](https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=They%20are%20difficult%20to%20control,an%20anxiety%20disorder%20\(1\).) mental health conditions in the world. In the U.S. alone, over 1 in 20 people will have GAD at some point in their life. And this number seems to be [going up](https://time.com/6308096/therapy-mental-health-worse-us/) in recent years. According to the CDC, about [1 in 6 adults](https://www.cdc.gov/nchs/products/databriefs/db378.htm) said they had experienced some symptoms of anxiety within the past 2 weeks.
With this in mind, there’s a high chance that either you — or a friend or family member — will deal with [anxiety](https://www.accp.com/docs/bookstore/acsap/a17b2_sample.pdf) at some point. But there are many good treatments that can help if anxiety is disrupting your life. And antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best choices.
## What is generalized anxiety disorder?
[Generalized anxiety disorder](https://www.goodrx.com/conditions/generalized-anxiety-disorder) (GAD) is a mental health condition where your fears and worries are hard to control. People with GAD have anxiety almost every day, to the point where it causes problems at work, school, or home.
Symptoms of GAD include:
- Feeling anxious or worried most of the time
- Having a hard time managing your worries
- Feeling restless, jittery, or on edge
- Getting tired easily
- Having a hard time concentrating, or feeling like your mind “goes blank”
- Feeling irritable
- Having muscle tension
- Experiencing difficulty falling asleep or staying asleep, or feeling like sleep isn’t restful
### Can you have depression and anxiety at the same time?
Yes. [Major depression](https://www.goodrx.com/conditions/depression) and GAD are separate disorders, but it’s possible to have them both [at the same time](https://www.goodrx.com/conditions/generalized-anxiety-disorder/anxiety-and-depression). They have their own unique symptoms, but both can make it hard to function in daily life. And both can be treated with therapy and/or medications — including antidepressants.
## Can SSRIs and SNRIs help with anxiety?
Yes. For many people, SSRIs and SNRIs are a great [first-choice treatment](https://www.aafp.org/pubs/afp/issues/2015/0501/p617.html) for generalized anxiety. Though they’re technically called “antidepressants,” these medications are also used to treat many different [anxiety disorders](https://www.goodrx.com/health-topic/anxiety-disorders) — including GAD.
SSRIs and SNRIs used for [GAD](https://adaa.org/resources-professionals/practice-guidelines-gad) include:
- [Citalopram](https://www.goodrx.com/citalopram/what-is#tips) (Celexa)
- [Escitalopram](https://www.goodrx.com/lexapro/what-is#tips) (Lexapro)
- [Sertraline](https://www.goodrx.com/zoloft/what-is#tips) (Zoloft)
- [Paroxetine](https://www.goodrx.com/paroxetine/what-is#tips) (Paxil)
- [Fluoxetine](https://www.goodrx.com/prozac/what-is#tips) (Prozac)
- [Fluvoxamine](https://www.goodrx.com/fluvoxamine/what-is#tips) (Luvox)
- [Duloxetine](https://www.goodrx.com/cymbalta/what-is#tips) (Cymbalta)
- [Venlafaxine](https://www.goodrx.com/venlafaxine/what-is#tips) (Effexor)
Promotion disclosure
Anxiety medicationsCompare prices and information on the most popular Anxiety medications.
- Lexapro
Escitalopram
\$11.47Lowest price
[Save now](https://www.goodrx.com/lexapro)
- Zoloft
Sertraline
\$11.10Lowest price
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- Xanax
Alprazolam
\$9.93Lowest price
[Save now](https://www.goodrx.com/xanax)
[Compare all medications](https://www.goodrx.com/conditions/anxiety/drugs)
Some of these medications are FDA approved for generalized anxiety, while others are used “[off-label](https://www.goodrx.com/drugs/medication-basics/off-label-drug-prescriptions).”
### How do SSRIs and SNRIs work for anxiety?
Experts don’t know exactly how SSRIs and SNRIs work for anxiety. They seem to boost the activity of certain chemical messengers (neurotransmitters) in the brain, especially [serotonin](https://www.goodrx.com/health-topic/hormones/serotonin) and norepinephrine. These chemicals play a role in anxiety, mood, and general feelings of well-being.
### What’s the difference between SSRIs and SNRIs?
The [main difference](https://www.goodrx.com/health-topic/mental-health/ssris-vs-snris-differences) is that SSRIs mostly affect serotonin, while SNRIs affect both serotonin andnorepinephrine. SSRIs and SNRIs also have slightly different side effects, medication interactions, and dosage options.
## When to talk to your doctor about antidepressants for anxiety
If you’re considering antidepressants, talk with your healthcare provider. They’ll take note of your symptoms and confirm if you have GAD. You and your provider can then work together to decide if it makes sense to try a daily medication for anxiety, like an SSRI or a SSRI.
Your provider can also help you understand what other things might be helpful for your anxiety, like [therapy](https://www.goodrx.com/health-topic/mental-health/why-do-people-go-to-therapy) or [other types of medications](https://www.goodrx.com/conditions/generalized-anxiety-disorder/treating-anxiety-medication-and-therapy-options) (more on these below). And they can figure out whether any other [health conditions](https://www.goodrx.com/conditions/generalized-anxiety-disorder/causes#illness) could be affecting your anxiety, like [diabetes](https://www.goodrx.com/conditions/diabetes) or [insomnia](https://www.goodrx.com/conditions/insomnia).
## How long should you take antidepressants for anxiety?
SSRIs and SNRIs for anxiety take [about 1 month](https://www.goodrx.com/conditions/depression/time-for-antidepressants-to-work) to [start working](https://www.goodrx.com/conditions/depression/signs-your-antidepressant-is-working). If the medication seems helpful, your provider may suggest you continue taking it for 6 to 12 months.
After this time period, some people work with their provider to [taper down and stop](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants) the medication. Other times, it can make sense to continue antidepressants for a longer time. It all depends on your unique symptoms, and whether other things have been helpful for your anxiety, too — like therapy or lifestyle changes.
### Can antidepressants make anxiety worse at the start?
Yes. In fact, about [2 in 3 people](https://www.psychiatrictimes.com/view/managing-adverse-effects-antidepressants) feel more anxious, irritable, and agitated in the first couple weeks after starting an antidepressant. This seems [especially common](https://www.cambridge.org/core/services/aop-cambridge-core/content/view/635B85506FA0D008FEF309F1AE5EBF5E/S0007125000006784a.pdf/antidepressantinduced_jitterinessanxiety_syndrome_systematic_review.pdf) in people with major depression, but it can happen with GAD too.
These “jittery” feelings usually start to fade after the first week. In some cases, your healthcare provider might prescribe another short-term medication, like a [benzodiazepine](https://www.goodrx.com/conditions/generalized-anxiety-disorder/benzodiazepine-treatment), to help you feel better during these first few weeks.
## Do SSRIs and SNRIs have side effects?
Yes. [Side effects](https://www.goodrx.com/classes/ssris/ssris-what-you-should-know-side-effects) are possible when taking these medications. Common side effects of SSRIs and SNRIs include fatigue, upset stomach, trouble sleeping, and sexual problems.
Keep in mind: If you do have side effects, they often go away within the first few weeks of starting the medication. Sexual side effects, like [erectile dysfunction](https://www.goodrx.com/drugs/side-effects/antidepressants-anti-anxiety-drugs-erectile-dysfunction-side-effect) or [low libido](https://www.goodrx.com/conditions/low-libido/prevent-low-libido-from-antidepressants), are the most likely to stick around.
## Additional medications to help treat anxiety
SSRIs and SNRIs are great first-choice medications for anxiety. But if your anxiety doesn’t get better, or only partially improves, after you start taking medication, your provider might suggest another approach. This could mean switching to another SSRI or SNRI. Or it might mean trying a different type of medication altogether.
Other types of medications that can be helpful for anxiety include:
- [Buspirone](https://www.goodrx.com/buspirone/what-is) (Buspar)
- [Pregabalin](https://www.goodrx.com/lyrica/what-is) (Lyrica)
- [Mirtazapine](https://www.goodrx.com/mirtazapine/what-is) (Remeron)
- [Quetiapine](https://www.goodrx.com/quetiapine/what-is) (Seroquel)
- [Hydroxyzine](https://www.goodrx.com/hydroxyzine-pamoate/what-is) (Atarax)
- [Imipramine](https://www.goodrx.com/tofranil/what-is) (Tofranil)
These medications can be prescribed on their own, or they can be used to boost the effectiveness of an SSRI or SNRI.
As mentioned above, benzodiazepines like [lorazepam](https://www.goodrx.com/lorazepam/what-is#tips) (Ativan) can also be used to help treat anxiety. These types of medications are often prescribed just for short-term use, usually to help manage anxiety symptoms while you’re waiting for an SSRI or SNRI to take effect.
## Therapy vs. medication for anxiety: Which is better?
Therapy and medications are both great options for treating anxiety. There’s evidence that [cognitive behavioral therapy](https://www.goodrx.com/health-topic/mental-health/cognitive-behavioral-therapy) (CBT) actually works [just as well](https://www.uptodate.com/contents/generalized-anxiety-disorder-in-adults-management?search=generalized%20anxiety%20disorder&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H3385476) as medication for treating anxiety.
So how do you decide? Remember that anxiety treatment doesn’t have a one-size-fits-all approach. The right treatment for you depends on:
- Your personal preferences
- Whether you have access to therapist
- How much a medication will cost
- Your symptoms
- Whether you have other mental and physical health problems
Many people also choose to do therapy and take medication at the same time. Again, when it comes to anxiety, it’s all about what works best for you.
## Lifestyle tips to help manage anxiety
In addition to medication and therapy, there are other things that can [help with your anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/cure#natural-remedies). These include:
- [Exercising](https://www.goodrx.com/well-being/movement-exercise/regular-exercise)
- Practicing [mindfulness](https://www.goodrx.com/health-topic/mental-health/guide-to-mindfulness), like yoga or meditation
- Eating [nutritious foods](https://www.goodrx.com/well-being/diet-nutrition)
- Getting enough good-quality [sleep](https://www.goodrx.com/well-being/sleep/emotional-effects-lack-of-sleep-deprivation) every night
- Cutting down on [alcohol](https://www.goodrx.com/well-being/substance-use/alcohol-anxiety-relationship)
Certain herbs and supplements may also be helpful, like [cannabidiol](https://www.goodrx.com/classes/cannabinoids/cbd-anxiety-treatment), [chamomile](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646235/), and [fish oil](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324500/). But be careful: Many over-the-counter products cause side effects and can interfere with other medications you are taking. Talk with your provider about whether these treatments could be right for you.
## Research about antidepressants and anxiety
Researchers are continuing to investigate how and why antidepressants help to improve anxiety. Some [researchers](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596392/) want to figure out the best length of treatment. [Other researchers](https://www.nature.com/articles/4001852) want to know why some people get better when taking SSRIs and SNRIs — and why others don't.
Researchers are also looking into newer antidepressants like [Viibryd](https://www.goodrx.com/viibryd/what-is), and other new [types of medications](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869976/) like esketamine (Spravato). [Understanding new brain pathways](https://www.ncbi.nlm.nih.gov/pubmed/30540948) may also help scientists explore new treatments.
## The bottom line
When it comes to medications for anxiety, antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best tools out there. But other things can help too, like therapy, exercise, and sufficient quality sleep at night.
If you’re dealing with anxiety, talk with your healthcare provider. They can help you understand if you have an anxiety disorder and whether an antidepressant may help.

## Why trust our experts?


Written by:
[Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta)
Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.


Edited by:
[Sophie Vergnaud, MD](https://www.goodrx.com/about/bio/sophie-vergnaud)
Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology.
[Our editorial standards](https://www.goodrx.com/about/editorial-guidelines)
[Meet our experts](https://www.goodrx.com/about/health#meet-our-healthcare-experts)
## References
Anxiety and Depression Association of America. (2015). [Clinical practice review for GAD](https://adaa.org/resources-professionals/practice-guidelines-gad).
Batelaan, N. M., et al. (2017). [Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: Systematic review and meta-analysis of relapse prevention trials](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596392/). *British Medical Journal*.
### View All References (13)
Bystritsky, A. (2006). [Treatment-resistant anxiety disorders](https://www.nature.com/articles/4001852#citeas). *Molecular Psychiatry*.
Centers for Disease Control and Prevention (2020). [Symptoms of generalized anxiety disorder among adults: United States, 2019](https://www.cdc.gov/nchs/products/databriefs/db378.htm).
Craske, M., et al. (2023). [Generalized anxiety disorder in adults: Management](https://www.uptodate.com/contents/generalized-anxiety-disorder-in-adults-management?search=generalized%20anxiety%20disorder&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H3385476). UpToDate.
Ducharme, J. (2023). [America has reached peak therapy. Why is our mental health getting worse?](https://time.com/6308096/therapy-mental-health-worse-us/) TIME.
Kehoe, W. A., et al. (2017). [Generalized anxiety disorder](https://www.accp.com/docs/bookstore/acsap/a17b2_sample.pdf). Ambulatory Care Self-Assessment Program 2017 Book 2 Neurologic/Psychiatric Care.
Locke, A. B., et al. (2015). [Diagnosis and management of generalized anxiety disorder and panic disorder in adults](https://www.aafp.org/pubs/afp/issues/2015/0501/p617.html). *American Family Physician*.
Mao, J. J., et al. (2016). [Long-term chamomile (matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646235/). *Phytomedicine*.
Murrough, J. W., et al. (2015). [Emerging drugs for the treatment of anxiety](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869976/). *Expert Opinion on Emerging Drugs*.
Panayotis, N., et al. (2018). [Importin α5 regulates anxiety through MeCP2 and sphingosine kinase 1](https://www.ncbi.nlm.nih.gov/pubmed/30540948). *Cell Reports*.
Sienaert, P. (2014). [Managing the adverse effects of antidepressants](https://www.psychiatrictimes.com/view/managing-adverse-effects-antidepressants). *Psychiatric Times*.
Sinclair, L. I., et al. (2009). [Antidepressant-induced jitteriness/anxiety syndrome: Systematic review](https://www.cambridge.org/core/services/aop-cambridge-core/content/view/635B85506FA0D008FEF309F1AE5EBF5E/S0007125000006784a.pdf/antidepressantinduced_jitterinessanxiety_syndrome_systematic_review.pdf). *The British Journal of Psychiatry*.
Su, K., et al. (2018). [Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: A systematic review and meta-analysis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324500/). *Journal of the American Medical Association Network Open*.
World Health Organization. (2023). [Anxiety disorders](https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=They%20are%20difficult%20to%20control,an%20anxiety%20disorder%20\(1\).).
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines).
Anxiety and Depression Association of America. (2015). [Clinical practice review for GAD](https://adaa.org/resources-professionals/practice-guidelines-gad).
Batelaan, N. M., et al. (2017). [Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: Systematic review and meta-analysis of relapse prevention trials](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596392/). *British Medical Journal*.
Bystritsky, A. (2006). [Treatment-resistant anxiety disorders](https://www.nature.com/articles/4001852#citeas). *Molecular Psychiatry*.
Centers for Disease Control and Prevention (2020). [Symptoms of generalized anxiety disorder among adults: United States, 2019](https://www.cdc.gov/nchs/products/databriefs/db378.htm).
Craske, M., et al. (2023). [Generalized anxiety disorder in adults: Management](https://www.uptodate.com/contents/generalized-anxiety-disorder-in-adults-management?search=generalized%20anxiety%20disorder&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H3385476). UpToDate.
Ducharme, J. (2023). [America has reached peak therapy. Why is our mental health getting worse?](https://time.com/6308096/therapy-mental-health-worse-us/) TIME.
Kehoe, W. A., et al. (2017). [Generalized anxiety disorder](https://www.accp.com/docs/bookstore/acsap/a17b2_sample.pdf). Ambulatory Care Self-Assessment Program 2017 Book 2 Neurologic/Psychiatric Care.
Locke, A. B., et al. (2015). [Diagnosis and management of generalized anxiety disorder and panic disorder in adults](https://www.aafp.org/pubs/afp/issues/2015/0501/p617.html). *American Family Physician*.
Mao, J. J., et al. (2016). [Long-term chamomile (matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646235/). *Phytomedicine*.
Murrough, J. W., et al. (2015). [Emerging drugs for the treatment of anxiety](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869976/). *Expert Opinion on Emerging Drugs*.
Panayotis, N., et al. (2018). [Importin α5 regulates anxiety through MeCP2 and sphingosine kinase 1](https://www.ncbi.nlm.nih.gov/pubmed/30540948). *Cell Reports*.
Sienaert, P. (2014). [Managing the adverse effects of antidepressants](https://www.psychiatrictimes.com/view/managing-adverse-effects-antidepressants). *Psychiatric Times*.
Sinclair, L. I., et al. (2009). [Antidepressant-induced jitteriness/anxiety syndrome: Systematic review](https://www.cambridge.org/core/services/aop-cambridge-core/content/view/635B85506FA0D008FEF309F1AE5EBF5E/S0007125000006784a.pdf/antidepressantinduced_jitterinessanxiety_syndrome_systematic_review.pdf). *The British Journal of Psychiatry*.
Su, K., et al. (2018). [Association of use of omega-3 polyunsaturated fatty acids with changes in severity of anxiety symptoms: A systematic review and meta-analysis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324500/). *Journal of the American Medical Association Network Open*.
World Health Organization. (2023). [Anxiety disorders](https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=They%20are%20difficult%20to%20control,an%20anxiety%20disorder%20\(1\).).
##### *For additional resources or to connect with mental health services in your area, call SAMHSA’s National Helpline at* [*1-800-662-4357*](tel:1-800-662-4357)*. For immediate assistance, call the* [*National Suicide Prevention Lifeline*](https://988lifeline.org/) *at* [*988*](tel:988)*, or text HOME to* [*741-741*](<sms: 741-741>) *to reach the* [*Crisis Text Line*](https://www.crisistextline.org/)*.*

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| Readable Markdown | ## Key takeaways:
- Generalized anxiety disorder (GAD) is a mental health condition where you feel worried and anxious a lot — to the point where it gets in the way of your daily life.
- Anxiety can be treated with therapy and medications, including antidepressants.
- Two of the best types of antidepressant medications for GAD are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs).
- Despite the name, many antidepressants are also FDA approved for other health conditions — not just depression. Antidepressants are used to treat anxiety disorders, eating disorders, certain types of pain, and more.
Generalized anxiety disorder (GAD) is one of the [most common](https://www.who.int/news-room/fact-sheets/detail/anxiety-disorders#:~:text=They%20are%20difficult%20to%20control,an%20anxiety%20disorder%20\(1\).) mental health conditions in the world. In the U.S. alone, over 1 in 20 people will have GAD at some point in their life. And this number seems to be [going up](https://time.com/6308096/therapy-mental-health-worse-us/) in recent years. According to the CDC, about [1 in 6 adults](https://www.cdc.gov/nchs/products/databriefs/db378.htm) said they had experienced some symptoms of anxiety within the past 2 weeks.
With this in mind, there’s a high chance that either you — or a friend or family member — will deal with [anxiety](https://www.accp.com/docs/bookstore/acsap/a17b2_sample.pdf) at some point. But there are many good treatments that can help if anxiety is disrupting your life. And antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best choices.
[Generalized anxiety disorder](https://www.goodrx.com/conditions/generalized-anxiety-disorder) (GAD) is a mental health condition where your fears and worries are hard to control. People with GAD have anxiety almost every day, to the point where it causes problems at work, school, or home.
Symptoms of GAD include:
- Feeling anxious or worried most of the time
- Having a hard time managing your worries
- Feeling restless, jittery, or on edge
- Getting tired easily
- Having a hard time concentrating, or feeling like your mind “goes blank”
- Feeling irritable
- Having muscle tension
- Experiencing difficulty falling asleep or staying asleep, or feeling like sleep isn’t restful
Yes. [Major depression](https://www.goodrx.com/conditions/depression) and GAD are separate disorders, but it’s possible to have them both [at the same time](https://www.goodrx.com/conditions/generalized-anxiety-disorder/anxiety-and-depression). They have their own unique symptoms, but both can make it hard to function in daily life. And both can be treated with therapy and/or medications — including antidepressants.
## Can SSRIs and SNRIs help with anxiety?
Yes. For many people, SSRIs and SNRIs are a great [first-choice treatment](https://www.aafp.org/pubs/afp/issues/2015/0501/p617.html) for generalized anxiety. Though they’re technically called “antidepressants,” these medications are also used to treat many different [anxiety disorders](https://www.goodrx.com/health-topic/anxiety-disorders) — including GAD.
SSRIs and SNRIs used for [GAD](https://adaa.org/resources-professionals/practice-guidelines-gad) include:
Compare prices and information on the most popular Anxiety medications.
Some of these medications are FDA approved for generalized anxiety, while others are used “[off-label](https://www.goodrx.com/drugs/medication-basics/off-label-drug-prescriptions).”
Experts don’t know exactly how SSRIs and SNRIs work for anxiety. They seem to boost the activity of certain chemical messengers (neurotransmitters) in the brain, especially [serotonin](https://www.goodrx.com/health-topic/hormones/serotonin) and norepinephrine. These chemicals play a role in anxiety, mood, and general feelings of well-being.
The [main difference](https://www.goodrx.com/health-topic/mental-health/ssris-vs-snris-differences) is that SSRIs mostly affect serotonin, while SNRIs affect both serotonin andnorepinephrine. SSRIs and SNRIs also have slightly different side effects, medication interactions, and dosage options.
If you’re considering antidepressants, talk with your healthcare provider. They’ll take note of your symptoms and confirm if you have GAD. You and your provider can then work together to decide if it makes sense to try a daily medication for anxiety, like an SSRI or a SSRI.
Your provider can also help you understand what other things might be helpful for your anxiety, like [therapy](https://www.goodrx.com/health-topic/mental-health/why-do-people-go-to-therapy) or [other types of medications](https://www.goodrx.com/conditions/generalized-anxiety-disorder/treating-anxiety-medication-and-therapy-options) (more on these below). And they can figure out whether any other [health conditions](https://www.goodrx.com/conditions/generalized-anxiety-disorder/causes#illness) could be affecting your anxiety, like [diabetes](https://www.goodrx.com/conditions/diabetes) or [insomnia](https://www.goodrx.com/conditions/insomnia).
SSRIs and SNRIs for anxiety take [about 1 month](https://www.goodrx.com/conditions/depression/time-for-antidepressants-to-work) to [start working](https://www.goodrx.com/conditions/depression/signs-your-antidepressant-is-working). If the medication seems helpful, your provider may suggest you continue taking it for 6 to 12 months.
After this time period, some people work with their provider to [taper down and stop](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants) the medication. Other times, it can make sense to continue antidepressants for a longer time. It all depends on your unique symptoms, and whether other things have been helpful for your anxiety, too — like therapy or lifestyle changes.
Yes. In fact, about [2 in 3 people](https://www.psychiatrictimes.com/view/managing-adverse-effects-antidepressants) feel more anxious, irritable, and agitated in the first couple weeks after starting an antidepressant. This seems [especially common](https://www.cambridge.org/core/services/aop-cambridge-core/content/view/635B85506FA0D008FEF309F1AE5EBF5E/S0007125000006784a.pdf/antidepressantinduced_jitterinessanxiety_syndrome_systematic_review.pdf) in people with major depression, but it can happen with GAD too.
These “jittery” feelings usually start to fade after the first week. In some cases, your healthcare provider might prescribe another short-term medication, like a [benzodiazepine](https://www.goodrx.com/conditions/generalized-anxiety-disorder/benzodiazepine-treatment), to help you feel better during these first few weeks.
Yes. [Side effects](https://www.goodrx.com/classes/ssris/ssris-what-you-should-know-side-effects) are possible when taking these medications. Common side effects of SSRIs and SNRIs include fatigue, upset stomach, trouble sleeping, and sexual problems.
Keep in mind: If you do have side effects, they often go away within the first few weeks of starting the medication. Sexual side effects, like [erectile dysfunction](https://www.goodrx.com/drugs/side-effects/antidepressants-anti-anxiety-drugs-erectile-dysfunction-side-effect) or [low libido](https://www.goodrx.com/conditions/low-libido/prevent-low-libido-from-antidepressants), are the most likely to stick around.
SSRIs and SNRIs are great first-choice medications for anxiety. But if your anxiety doesn’t get better, or only partially improves, after you start taking medication, your provider might suggest another approach. This could mean switching to another SSRI or SNRI. Or it might mean trying a different type of medication altogether.
Other types of medications that can be helpful for anxiety include:
These medications can be prescribed on their own, or they can be used to boost the effectiveness of an SSRI or SNRI.
As mentioned above, benzodiazepines like [lorazepam](https://www.goodrx.com/lorazepam/what-is#tips) (Ativan) can also be used to help treat anxiety. These types of medications are often prescribed just for short-term use, usually to help manage anxiety symptoms while you’re waiting for an SSRI or SNRI to take effect.
Therapy and medications are both great options for treating anxiety. There’s evidence that [cognitive behavioral therapy](https://www.goodrx.com/health-topic/mental-health/cognitive-behavioral-therapy) (CBT) actually works [just as well](https://www.uptodate.com/contents/generalized-anxiety-disorder-in-adults-management?search=generalized%20anxiety%20disorder&source=search_result&selectedTitle=2~150&usage_type=default&display_rank=2#H3385476) as medication for treating anxiety.
So how do you decide? Remember that anxiety treatment doesn’t have a one-size-fits-all approach. The right treatment for you depends on:
- Your personal preferences
- Whether you have access to therapist
- How much a medication will cost
- Your symptoms
- Whether you have other mental and physical health problems
Many people also choose to do therapy and take medication at the same time. Again, when it comes to anxiety, it’s all about what works best for you.
In addition to medication and therapy, there are other things that can [help with your anxiety](https://www.goodrx.com/conditions/generalized-anxiety-disorder/cure#natural-remedies). These include:
- [Exercising](https://www.goodrx.com/well-being/movement-exercise/regular-exercise)
- Practicing [mindfulness](https://www.goodrx.com/health-topic/mental-health/guide-to-mindfulness), like yoga or meditation
- Eating [nutritious foods](https://www.goodrx.com/well-being/diet-nutrition)
- Getting enough good-quality [sleep](https://www.goodrx.com/well-being/sleep/emotional-effects-lack-of-sleep-deprivation) every night
- Cutting down on [alcohol](https://www.goodrx.com/well-being/substance-use/alcohol-anxiety-relationship)
Certain herbs and supplements may also be helpful, like [cannabidiol](https://www.goodrx.com/classes/cannabinoids/cbd-anxiety-treatment), [chamomile](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646235/), and [fish oil](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324500/). But be careful: Many over-the-counter products cause side effects and can interfere with other medications you are taking. Talk with your provider about whether these treatments could be right for you.
Researchers are continuing to investigate how and why antidepressants help to improve anxiety. Some [researchers](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596392/) want to figure out the best length of treatment. [Other researchers](https://www.nature.com/articles/4001852) want to know why some people get better when taking SSRIs and SNRIs — and why others don't.
Researchers are also looking into newer antidepressants like [Viibryd](https://www.goodrx.com/viibryd/what-is), and other new [types of medications](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869976/) like esketamine (Spravato). [Understanding new brain pathways](https://www.ncbi.nlm.nih.gov/pubmed/30540948) may also help scientists explore new treatments.
## The bottom line
When it comes to medications for anxiety, antidepressants like selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) are some of the best tools out there. But other things can help too, like therapy, exercise, and sufficient quality sleep at night.
If you’re dealing with anxiety, talk with your healthcare provider. They can help you understand if you have an anxiety disorder and whether an antidepressant may help.



Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.


Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology.
GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines). |
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