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URLhttps://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments
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Meta TitleMedications and Treatments for Major Depressive Disorder (MDD) - GoodRx
Meta DescriptionVarious medications can effectively treat major depressive disorder (MDD). See a list here, plus alternative treatments and therapies for depression.
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Key takeaways: Clinical depression — also known as major depressive disorder — is a common mental health condition. There are many different treatment options for depression, including therapy and medication. Much of the time, depression can be successfully treated. It’s important to get care if you’re experiencing symptoms. Clinical depression , also called major depressive disorder or depression, is one of the most common mental health conditions in the world. It’s estimated that 1 in 5 people in the U.S. will experience depression over the course of their lifetime. And when you have depression, it can affect your life in many different ways — including your physical health, your close relationships, and your job. Fortunately, treatment can help. Let’s take a closer look at medications for major depressive disorder, as well as therapy and other options.   Depression is a mental health condition where you feel numb, empty, and sad most of the time. It can also make you less interested in your normal activities, and take a toll at work, at home, and in your relationships.  It’s normal to feel sad sometimes — but major depressive disorder is much more than that. It impacts your daily life and can lead to serious symptoms like self-harm or suicide.  Major depression can cause many different symptoms . These include:  Feeling sad, hopeless, or empty Feelings of guilt or worthlessness Loss of interest in activities you used to enjoy Appetite changes, and weight gain or weight loss Difficulty sleeping or sleeping more than normal Feeling tired, or lack of energy Physical restlessness, or feeling heavy and weighed down Difficulty concentrating or memory problems Having thoughts of suicide or thinking you would be better off dead To be diagnosed with depression, you need to have at least five of these symptoms, for at least 2 weeks. But in reality, depression can look different in different people.  Some people experience mild depression, with fewer symptoms. Other people have more severe depression . And some people also have physical discomfort or pain as a result of depression.  There are many medications that can help with depression. These typically include antidepressants , mood stabilizers, and atypical antipsychotics. You and your healthcare professional will work together to find the right medication — or combination of medications — for your unique symptoms.  Compare prices and information on the most popular Depression medications. Here are some of the options.  When it comes to treating depression, SSRIs are a good first choice for many people. They’re also used to treat many other mental health conditions, like anxiety disorders and post-traumatic stress disorder (PTSD). Examples include:  SNRIs are another good first-choice medication for treating depression. Just like SSRIs, they’re also used for many other mental health conditions. And they can be helpful for some types of chronic pain, too. Options include: These are antidepressants that don’t fit well into other categories, because they work a little differently in your body. Examples include:  Atypical antidepressants are often used as an add-on to other medications. But they can also work well on their own for some people. Keep in mind that esketamine is typically only used in people with suicidal thoughts, or if you have treatment-resistant depression (more on this below).  TCAs are an older type of antidepressant. They’re less commonly used because they can come with more side effects than SSRIs and SNRIs. But for some people they can be a great option. Examples include:  Monoamine oxidase inhibitors ( MAOIs ) are another type of older antidepressant. Options include: Just like TCAs, they’re not usually a first-choice medication because of their side effects. You also can’t eat certain foods while taking them, which can be a hassle. But again — for some people, MAOIs are a good match. Mood stabilizers and atypical antipsychotics are two other types of medications that are used to treat depression. They’re often used together with antidepressants, such as SSRIs or SNRIs. Your healthcare professional might suggest adding one of these if you’re not getting enough relief from an antidepressant alone.  Sometimes a medication won’t be helpful enough at first, or it may have side effects you don’t like. But it’s a good idea to give the medication enough time to see if it works for you. It may take up to 8 weeks for your symptoms to start getting better.  It’s also worth mentioning that antidepressant medications shouldn’t be stopped abruptly . This can lead to discontinuation symptoms like nausea, headaches, trouble sleeping, and dizziness. Talk with your healthcare professional if you’re considering stopping your medication — they can help you create a plan. And finally: Be aware that some depression medications may increase your risk for suicidal thoughts, especially in young people (children or teens). If this happens, get emergency help. Call the National Suicide Prevention Lifeline at 988 or text “HOME” to 741-741 to reach the Crisis Text Line .  Featuring Susan Samuels, MD Reviewed by Sanjai Sinha, MD | September 12, 2025 Therapy can be an essential part of treatment for major depression, too — either on its own, or together with medication. Sometimes, therapy may help within just a few weeks. Or, it can take longer depending on your situation.  There are different types of therapy that can help to treat depression, including: Cognitive behavioral therapy (CBT) Interpersonal therapy (IPT) Psychodynamic psychotherapy Supportive therapy Mindfulness-based cognitive therapy (MBCT) When it comes to a therapist, it’s important to find the right fit for you. There are different ways to find a therapist , such as searching online or asking for recommendations. You can do therapy online over video, too.  In some cases, therapy may include other people. For example, family or couples therapy can often be helpful, especially if depression has affected your relationships. And group therapy can be a great way to connect with other people going through similar experiences.  Treatment-resistant depression (TRD) is when your depression symptoms don’t go away completely, even after you’ve tried a couple of different medications. And it’s pretty common, too. In fact, TRD may happen in as many as 1 in 3 people with depression.  But having TRD doesn’t mean you’re out of options . It just means you might have to try a different type of treatment to get relief. Here are some of the treatments that can help if you have TRD:  Switching to a new antidepressant: Changing to a different type of antidepressant can help some people with TRD.  Adding on a second or third medication: This could mean adding another antidepressant, or an antipsychotic medication. Thyroid hormone and lithium are options for some people, too.  Adding on therapy: If medications haven’t worked on their own, adding on therapy can sometimes get results.  Trying brain stimulation therapies: These are medical procedures that stimulate your brain . Examples include transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT).  Using esketamine and ketamine: Esketamine (Spravato) is an FDA-approved nasal spray for treating TRD. Ketamine is a similar medication that’s often used off-label to treat depression, including TRD.  Taking olanzapine/fluoxetine (Symbyax): Symbyax is a combination medication made of two medications: olanzapine and fluoxetine. It’s also FDA-approved for treating TRD.  There are also new treatments that may grow in use over time, such as psilocybin (commonly known as magic mushrooms). This is a psychedelic compound that shows some promising benefits in treating depression — including TRD. But more research is needed before we can say for sure how well it works. Some over-the-counter (OTC) supplements may help with depression. These include:  St. John’s wort: This is an herb that may be effective for depression . But it has side effects and it can interfere with other medications you’re taking. It can also be risky to mix with some prescription medications, including certain antidepressants.  Omega-3 fatty acids: These are “good fats” that are important for brain health . There’s some evidence that taking omega-3 may help with depression. L-methylfolate or folic acid: L-methylfolate is the active form of folic acid, a type of  vitamin B. It’s not clear how well folic acid works on its own for depression, but it may be helpful as an add-on to antidepressants .  So far, there’s not enough evidence that any of these supplements work better than medications and therapy. And remember: It’s always a good idea to talk with your healthcare team before taking a new supplement. OTC supplements may have side effects, or interact with your other medications.  Featuring Jacques Ambrose, MD, MPH, FAPA Reviewed by Karen Hovav, MD, FAAP | July 2, 2025 There are some important lifestyle changes and daily habits that can help manage your depression symptoms. These include:  Exercise: Exercise can help reduce depression symptoms, especially when combined with medication or therapy. Exercise doesn’t have to be complicated. Even simple things can help, like a short walk around the block or playing basketball in your driveway. Healthy diet: A nutritious diet full of fruits and vegetables may help with depressive symptoms. It’s especially important to get enough vitamins and minerals, including vitamin B12, folate, and magnesium. Sleep: Many people with depression have trouble sleeping. Working with your healthcare professional to get enough good quality sleep can help your other depression symptoms get better, too.  Mind-body therapies: Mind-body activities like yoga, tai chi, and meditation can also be helpful for people with depression. They’re also good for other things that can go hand-in-hand with depression, like pain, stress, and anxiety.  Light therapy: Sitting in front of a special bright light box can help with some types of depression, especially seasonal affective disorder . It’s hard to say. Technically, depression isn’t an illness that can be cured. But fortunately many people do fully recover from major depression — especially with treatment.  When it comes to depression, recovery is different for everyone. It depends on many things, including: Your symptoms Your family history Whether you’ve had an episode of depression before Your overall mental and physical health Your resources and social support For some people, depression will go away and never come back. But for other people, symptom episodes will come and go over time. In fact, at least 1 out of every 2 people will have another episode of depression sometime in their life. And the more episodes you have, the more likely it is you’ll have another one in the future.    If you think you may have depression, it’s a good idea to talk with your healthcare team. You can start with your primary care provider (PCP). They might be able to get you started on medication, or provide a referral to a qualified mental health professional.  If you don’t have a PCP, or aren’t sure where to start, ask friends and family for recommendations. If you’re covered by health insurance , you can also use your plan’s healthcare professional directory to look for a specialist in your area.    You can also start your search for mental health professionals online. Many of them offer either in-person or telehealth appointments. Check out the following databases:  You can also call the Substance Abuse and Mental Health Services Administration ( SAMHSA ) for more resources near you at . The National Alliance on Mental Illness (NAMI) also has a helpline you can call at 1-800-950-NAMI (6264) . The bottom line Depression is one of the most common mental health conditions. It will likely impact you or someone you love at some point in your life. While it may be scary or overwhelming to seek help for depression, it’s important to know that many treatment options are available. Not only are there many medications, but there are also nonmedication options and therapies that can help. Depression is treatable, and many people will achieve remission and remain symptom-free.  Why trust our experts? Christina Palmer, MD, is a board-certified family physician with a focus on chronic care management, women’s health, and mental health. She’s the co-author of the book, “Open Heart: When Open-Heart Surgery Becomes Your Best Option”. Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology. Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. If you or someone you know is having thoughts of suicide, you’re not alone and help is available. Call the National Suicide Prevention Lifeline at 988 or text “HOME” to 741-741 to reach the Crisis Text Line .  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines .
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[Depression](https://www.goodrx.com/conditions/depression) Depression # Medications and Other Treatment Options for Major Depressive Disorder [![Christina Palmer, MD](https://www.grxstatic.com/4f3rgqwzdznj/5cs5SpdTHjI2wBkIJDax23/76955170a2c6475bd181a780a454b2fa/Christina_Palmer_goodrx.jpg?w=96&q=85&fm=webp)](https://www.goodrx.com/about/bio/christina-palmer)[![Sarah Gupta, MD](https://www.grxstatic.com/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp?w=96&q=85&fm=webp)](https://www.goodrx.com/about/bio/sarah-gupta) Written by [Christina Palmer, MD](https://www.goodrx.com/about/bio/christina-palmer) \| Reviewed by [Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta) Updated on May 14, 2024 ![star](https://www.grxstatic.com/images/star-with-circle.svg)![Man sitting in a hospital waiting room looking worried.](https://www.grxstatic.com/4f3rgqwzdznj/2o2NteWffb2Ndo1Koq17wn/bc8739e765ac2afe643487763d060df0/man_sitting_in_a_waiting_room_1314818858.jpg?w=3840&q=99&fm=webp) MixMedia/iStock via Getty Images [Definition](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#definition)[Depression medications](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#depression-medications)[Therapy for depression](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#therapy-for-depression)[Treatment-resistant depression](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#treatment-resistant-depression)[Natural treatments](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#natural-treatments)[Lifestyle changes](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#lifestyle-changes)[Is it curable?](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#is-it-curable-)[Find help](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#find-help)[Bottom line](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#bottom-line)[References](https://www.goodrx.com/conditions/depression/guide-to-major-depressive-disorder-treatments#references) ## Key takeaways: - Clinical depression — also known as major depressive disorder — is a common mental health condition. - There are many different treatment options for depression, including therapy and medication. - Much of the time, depression can be successfully treated. It’s important to get care if you’re experiencing symptoms. [Clinical depression](https://www.goodrx.com/conditions/depression), also called major depressive disorder or depression, is one of the most common mental health conditions in the world. It’s estimated that [1 in 5 people](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2671413) in the U.S. will experience depression over the course of their lifetime. And when you have depression, it can affect your life in many different ways — including your physical health, your close relationships, and your job. Fortunately, treatment can help. Let’s take a closer look at medications for major depressive disorder, as well as therapy and other options. ## What is major depressive disorder (MDD)? Depression is a mental health condition where you feel numb, empty, and sad most of the time. It can also make you less interested in your normal activities, and take a toll at work, at home, and in your relationships. It’s normal to [feel sad](https://www.goodrx.com/health-topic/mental-health/why-am-i-so-sad) sometimes — but major depressive disorder is much more than that. It impacts your daily life and can lead to serious symptoms like self-harm or suicide. ### What are the symptoms of major depression? Major depression can cause many [different symptoms](https://www.goodrx.com/conditions/depression/do-i-have-depression-signs-symptoms). These include: - Feeling sad, hopeless, or empty - Feelings of guilt or worthlessness - Loss of interest in activities you used to enjoy - Appetite changes, and weight gain or weight loss - Difficulty sleeping or sleeping more than normal - Feeling tired, or lack of energy - Physical restlessness, or feeling heavy and weighed down - Difficulty concentrating or memory problems - Having thoughts of suicide or thinking you would be better off dead To be diagnosed with depression, you need to have at least five of these symptoms, for at least 2 weeks. But in reality, depression can look different in different people. Some people experience mild depression, with fewer symptoms. Other people have more [severe depression](https://www.goodrx.com/conditions/depression/severe-depression-symptoms). And some people also have physical discomfort or pain as a result of depression. ## What medications can be prescribed for major depressive disorder? There are many medications that can help with depression. These typically include [antidepressants](https://www.goodrx.com/conditions/depression/best-antidepressant-medication), mood stabilizers, and atypical antipsychotics. You and your healthcare professional will [work together](https://www.goodrx.com/conditions/depression/major-depressive-disorder-medication) to find the right medication — or combination of medications — for your unique symptoms. Promotion disclosure Depression medicationsCompare prices and information on the most popular Depression medications. - Lexapro Escitalopram \$11.47Lowest price [Save now](https://www.goodrx.com/lexapro) - Prozac Fluoxetine \$9.00Lowest price [Save now](https://www.goodrx.com/prozac) - Zoloft Sertraline \$12.01Lowest price [Save now](https://www.goodrx.com/zoloft) [Compare all medications](https://www.goodrx.com/conditions/depression/drugs) Here are some of the options. ### Selective serotonin reuptake inhibitors (SSRIs) When it comes to treating depression, [SSRIs](https://www.goodrx.com/classes/ssris/ssri-list) are a good first choice for many people. They’re also used to [treat many other](https://www.goodrx.com/health-topic/mental-health/ssris-vs-snris-differences) mental health conditions, like [anxiety disorders](https://www.goodrx.com/health-topic/anxiety-disorders) and post-traumatic stress disorder (PTSD). Examples include: - [escitalopram](https://www.goodrx.com/lexapro) (Lexapro) - [fluoxetine](https://www.goodrx.com/fluoxetine) (Prozac) - [sertraline](https://www.goodrx.com/sertraline) (Zoloft) - [citalopram](https://www.goodrx.com/citalopram/what-is) (Celexa) - [paroxetine](https://www.goodrx.com/paroxetine/what-is) (Paxil) ### Serotonin and norepinephrine reuptake inhibitors (SNRIs) [SNRIs](https://www.goodrx.com/classes/snris/snri-drugs-list) are another good first-choice medication for treating depression. Just like SSRIs, they’re also used for many other mental health conditions. And they can be helpful for some types of chronic pain, too. Options include: - [duloxetine](https://www.goodrx.com/duloxetine) (Cymbalta) - [venlafaxine](https://www.goodrx.com/venlafaxine) (Effexor) - [desvenlafaxine](https://www.goodrx.com/desvenlafaxine-er) (Pristiq) ### Atypical antidepressants These are antidepressants that don’t fit well into other categories, because they work a little differently in your body. Examples include: - [trazodone](https://www.goodrx.com/trazodone/what-is) - [mirtazapine](https://www.goodrx.com/mirtazapine) (Remeron) - [bupropion](https://www.goodrx.com/bupropion) (Wellbutrin) - [esketamine](https://www.goodrx.com/spravato/what-is) (Spravato) - [mirtazapine](https://www.goodrx.com/mirtazapine/what-is) (Remeron) Atypical antidepressants are often used as an add-on to other medications. But they can also work well on their own for some people. Keep in mind that esketamine is typically only used in people with suicidal thoughts, or if you have treatment-resistant depression (more on this below). ### Tricyclic antidepressants (TCAs) TCAs are an older type of antidepressant. They’re less commonly used because they can come with more side effects than SSRIs and SNRIs. But for some people they can be a great option. Examples include: - [amitriptyline](https://www.goodrx.com/amitriptyline) (Elavil) - [nortriptyline](https://www.goodrx.com/nortriptyline) (Pamelor) - [doxepin](https://www.goodrx.com/doxepin/what-is) (Sinequan) - [desipramine](https://www.goodrx.com/desipramine/what-is) (Norpramin) ### Monoamine oxidase inhibitors (MAOIs) Monoamine oxidase inhibitors ([MAOIs](https://www.goodrx.com/classes/maois)) are another type of older antidepressant. Options include: - [selegiline](https://www.goodrx.com/emsam/what-is) (Emsam) - [tranylcypromine](https://www.goodrx.com/tranylcypromine/what-is) (Parnate) - [isocarboxazid](https://www.goodrx.com/marplan/what-is) (Marplan) - [phenelzine](https://www.goodrx.com/phenelzine/what-is) (Nardil) Just like TCAs, they’re not usually a first-choice medication because of their side effects. You also can’t eat [certain foods](https://www.goodrx.com/classes/maois/what-is-maoi-diet) while taking them, which can be a hassle. But again — for some people, MAOIs are a good match. ### Mood stabilizers and atypical antipsychotics [Mood stabilizers](https://www.goodrx.com/classes/mood-stabilizers) and [atypical antipsychotics](https://www.goodrx.com/classes/atypical-antipsychotics) are two other types of medications that are used to treat depression. They’re often used together with antidepressants, such as SSRIs or SNRIs. Your healthcare professional might suggest adding one of these if you’re not getting enough relief from an antidepressant alone. ### Good to know Sometimes a medication won’t be helpful enough at first, or it may have side effects you don’t like. But it’s a good idea to give the medication enough time to see if it works for you. It may take [up to 8 weeks](https://www.ncbi.nlm.nih.gov/books/NBK361016/) for your symptoms to start getting better. It’s also worth mentioning that antidepressant medications shouldn’t be [stopped abruptly](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants). This can lead to [discontinuation symptoms](https://www.goodrx.com/classes/ssris/antidepressant-discontinuation-syndrome) like nausea, headaches, trouble sleeping, and dizziness. [Talk with your healthcare professional](https://www.goodrx.com/conditions/depression/how-to-talk-to-your-doctor-about-depression) if you’re considering stopping your medication — they can help you create a plan. And finally: Be aware that some depression medications may increase your risk for suicidal thoughts, especially in young people (children or teens). If this happens, get emergency help. Call the [National Suicide Prevention Lifeline](https://suicidepreventionlifeline.org/) at [988](tel:988) or text “HOME” to [741-741](sms:741-741) to reach the [Crisis Text Line](https://www.crisistextline.org/). ## What types of therapy can be used for depression? 3 Types of Psychotherapy That May Help Treat Depression Psychotherapy is one an effective treatment option for depression. Dr. Susan Samuels discusses the three main types of psychotherapy. 0 seconds of 3 minutes, 21 secondsVolume 90% Press shift question mark to access a list of keyboard shortcuts Keyboard Shortcuts EnabledDisabled Shortcuts Open/Close/ or ? Play/PauseSPACE Increase Volume↑ Decrease Volume↓ Seek Forward→ Seek Backward← Captions On/Offc Fullscreen/Exit Fullscreenf Mute/Unmutem Decrease Caption Size\- Increase Caption Size\+ or = Seek %0-9 Next Up Depression: ECT 01:09 Subtitle Settings Off English(US) Font Color White Font Opacity 100% Font Size 100% Font Family sans-serif Character Edge None Edge Color Black Background Color Black Background Opacity 75% Window Color Black Window Opacity 0% Reset White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 200% 175% 150% 125% 100% 75% 50% Arial Courier Georgia Impact Lucida Console Tahoma Times New Roman Trebuchet MS Verdana None Raised Depressed Uniform Drop Shadow White Black Red Green Blue Yellow Magenta Cyan White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 0% White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 0% 0\.5x 1x 1\.25x 1\.5x 2x facebook x Email Link https://cdn.jwplayer.com/previews/wbT5CGSu Copied Auto540p 1080p 720p 540p 360p 270p 180p Live 00:00 03:21 03:21 More Videos 01:09 Depression: ECT 02:11 The Types of Cancer that Immunotherapy Can Help Treat 04:42 True Champions Depression: Julie's Treatment 01:50 Depression: Overview 01:40 3 Types of IBS and How They’re Treated 03:38 True Champions Depression: Erin's Treatment 03:20 Treating Depression: What Psychiatrists and Psychologists Want You to Know 04:18 True Champions Depression: Erin's Depression Close Featuring [Susan Samuels, MD](https://www.goodrx.com/about/bio/undefined)Reviewed by [Sanjai Sinha, MD](https://www.goodrx.com/about/bio/sanjai-sinha) \| September 12, 2025 [Therapy](https://www.psychiatry.org/patients-families/depression/what-is-depression) can be an essential part of treatment for major depression, too — either on its own, or together with medication. Sometimes, [therapy](https://www.nimh.nih.gov/health/topics/psychotherapies) may help within just a few weeks. Or, it can take longer depending on your situation. There are [different types of therapy](https://www.apa.org/depression-guideline/adults) that can help to treat depression, including: - [Cognitive behavioral therapy](https://www.goodrx.com/health-topic/mental-health/cognitive-behavioral-therapy) (CBT) - [Interpersonal therapy](https://www.goodrx.com/health-topic/mental-health/interpersonal-therapy) (IPT) - Psychodynamic psychotherapy - Supportive therapy - Mindfulness-based cognitive therapy (MBCT) When it comes to a therapist, it’s important to find the right fit for you. There are different [ways to find a therapist](https://www.goodrx.com/health-topic/mental-health/how-to-find-a-therapist), such as searching online or asking for recommendations. You can do therapy online over video, too. In some cases, therapy may include other people. For example, family or couples therapy can often be helpful, especially if depression has affected your relationships. And group therapy can be a great way to connect with other people going through similar experiences. ## What treatments are available for treatment-resistant depression? Treatment-resistant depression (TRD) is when your depression symptoms don’t go away completely, even after you’ve tried a couple of different medications. And it’s pretty common, too. In fact, TRD may happen in as many as [1 in 3 people](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363299/) with depression. But having TRD doesn’t mean you’re out of [options](https://www.goodrx.com/conditions/depression/treatment-resistant-depression). It just means you might have to try a different type of treatment to get relief. Here are some of the treatments that can help if you have TRD: - **Switching to a new antidepressant:** Changing to a different type of antidepressant can help some people with TRD. - **Adding on a second or third medication:** This could mean adding another antidepressant, or an antipsychotic medication. Thyroid hormone and lithium are options for some people, too. - **Adding on therapy:** If medications haven’t worked on their own, adding on therapy can sometimes get results. - **Trying brain stimulation therapies:** These are medical procedures that [stimulate your brain](https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies). Examples include transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). - **Using esketamine and ketamine:** Esketamine (Spravato) is an FDA-approved nasal spray for treating TRD. Ketamine is a similar medication that’s often used [off-label](https://www.goodrx.com/drugs/medication-basics/off-label-drug-prescriptions) to treat depression, including TRD. - **Taking olanzapine/fluoxetine (Symbyax):** [Symbyax](https://www.goodrx.com/symbyax/what-is) is a combination medication made of two medications: olanzapine and fluoxetine. It’s also FDA-approved for treating TRD. There are also new treatments that may grow in use over time, such as [psilocybin](https://www.goodrx.com/conditions/depression/psilocybin-and-depression) (commonly known as magic mushrooms). This is a psychedelic compound that shows some promising benefits in treating depression — including TRD. But more research is needed before we can say for sure how well it works. ## What supplements can help for major depressive disorder? Some over-the-counter (OTC) [supplements](https://www.nytimes.com/2022/06/13/well/mind/supplements-depression-anxiety-treatment.html) may help with depression. These include: - **St. John’s wort:** This is [an herb that may be effective for depression](https://www.goodrx.com/conditions/depression/st-johns-wort-for-depression). But it has side effects and it can interfere with other medications you’re taking. It can also be risky to mix with some prescription medications, including certain antidepressants. - **Omega-3 fatty acids:** These are [“good fats” that are important for brain health](https://www.goodrx.com/well-being/diet-nutrition/omega-3-6-9-difference-benefits). There’s some [evidence](https://www.nature.com/articles/s41398-019-0515-5) that taking omega-3 may help with depression. - **L-methylfolate or folic acid:** L-methylfolate is the active form of folic acid, a type of vitamin B. It’s not clear how well folic acid works on its own for depression, but it may be helpful as an [add-on to antidepressants](https://www.sciencedirect.com/science/article/pii/S0965229921001114). So far, there’s not enough evidence that any of these supplements work better than medications and therapy. And remember: It’s always a good idea to talk with your healthcare team before taking a new supplement. OTC supplements may have side effects, or interact with your other medications. ## What lifestyle changes might help treat major depressive disorder? 5 Risks of Not Treating Major Depressive Disorder Even if your depression seems mild, treatment can improve your quality of life. 0 seconds of 3 minutes, 9 secondsVolume 90% Press shift question mark to access a list of keyboard shortcuts Keyboard Shortcuts EnabledDisabled Shortcuts Open/Close/ or ? Play/PauseSPACE Increase Volume↑ Decrease Volume↓ Seek Forward→ Seek Backward← Captions On/Offc Fullscreen/Exit Fullscreenf Mute/Unmutem Decrease Caption Size\- Increase Caption Size\+ or = Seek %0-9 Next Up Major Depressive Disorder, Explained in Under 2 Minutes 01:47 Subtitle Settings Off English Font Color White Font Opacity 100% Font Size 100% Font Family sans-serif Character Edge None Edge Color Black Background Color Black Background Opacity 75% Window Color Black Window Opacity 0% Reset White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 200% 175% 150% 125% 100% 75% 50% Arial Courier Georgia Impact Lucida Console Tahoma Times New Roman Trebuchet MS Verdana None Raised Depressed Uniform Drop Shadow White Black Red Green Blue Yellow Magenta Cyan White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 0% White Black Red Green Blue Yellow Magenta Cyan 100% 75% 50% 25% 0% 0\.5x 1x 1\.25x 1\.5x 2x facebook x Email Link https://cdn.jwplayer.com/previews/KPQDyync Copied Auto360p 1080p 720p 540p 360p 270p 180p Live 00:00 03:09 03:09 More Videos 01:47 Major Depressive Disorder, Explained in Under 2 Minutes 04:42 True Champions Depression: Julie's Treatment 03:38 True Champions Depression: Erin's Treatment 03:20 Treating Depression: What Psychiatrists and Psychologists Want You to Know 01:36 Is It Depression or Premenstrual Dysphoric Disorder (PMDD)? 02:24 Bipolar Disorder vs. Depression: What’s the Difference? 04:18 True Champions Depression: Erin's Depression 01:09 Depression: ECT Close Featuring [Jacques Ambrose, MD, MPH, FAPA](https://www.goodrx.com/about/bio/jacques-ambrose)Reviewed by [Karen Hovav, MD, FAAP](https://www.goodrx.com/about/bio/karen-hovav) \| July 2, 2025 There are some important lifestyle changes and daily habits that can help manage your depression symptoms. These include: - **Exercise:** [Exercise](http://faculty.cas.usf.edu/mbrannick/meta/CMA/Kvam2016ExerciseDepressionMeta.pdf) can help reduce depression symptoms, especially when combined with medication or therapy. Exercise doesn’t have to be complicated. Even simple things can help, like a short walk around the block or playing basketball in your driveway. - **Healthy diet:** A [nutritious diet](https://www.goodrx.com/well-being/diet-nutrition/what-is-a-healthy-diet) full of fruits and vegetables may help with depressive symptoms. It’s especially important to get enough vitamins and minerals, including vitamin B12, folate, and magnesium. - **Sleep:** Many people with depression have trouble sleeping. Working with your healthcare professional to get enough good quality sleep can help your other depression symptoms get better, too. - **Mind-body therapies:** [Mind-body activities](https://www.goodrx.com/well-being/alternative-treatments#mind-body-therapies) like yoga, tai chi, and meditation can also be helpful for people with depression. They’re also good for other things that can go hand-in-hand with depression, like pain, stress, and anxiety. - **Light therapy:** Sitting in front of a special bright [light box](https://www.goodrx.com/conditions/seasonal-affective-disorder/light-therapy-benefits) can help with some types of depression, especially [seasonal affective disorder](https://www.goodrx.com/conditions/seasonal-affective-disorder/seasonal-affective-disorder-symptoms). ## Can depression be cured? It’s hard to say. Technically, depression isn’t an illness that can be cured. But fortunately many people do fully recover from major depression — especially with treatment. When it comes to depression, recovery is different for everyone. It depends on many things, including: - Your symptoms - Your family history - Whether you’ve had an episode of depression before - Your overall mental and physical health - Your resources and social support For some people, depression will go away and never come back. But for other people, symptom episodes will come and go over time. In fact, at least [1 out of every 2](https://www.psychiatry.org/patients-families/depression) people will have another episode of depression sometime in their life. And the more episodes you have, the more likely it is you’ll have another one in the future. ## Where can you find healthcare professionals for depression treatment? If you think you may have depression, it’s a good idea to talk with your healthcare team. You can start with your primary care provider (PCP). They might be able to get you started on medication, or provide a referral to a qualified mental health professional. If you don’t have a PCP, or aren’t sure where to start, ask friends and family for recommendations. If you’re [covered by health insurance](https://www.goodrx.com/health-topic/mental-health/therapy-without-insurance), you can also use your plan’s healthcare professional directory to look for a specialist in your area. You can also start your search for mental health professionals online. Many of them offer either in-person or telehealth appointments. Check out the following databases: - [Good Therapy](https://www.goodtherapy.org/find-therapist.html) - [Therapy Den](https://www.therapyden.com/) - [Psychology Today](https://www.psychologytoday.com/us) - [QPoC Therapist Directory](https://providers.therapyforqpoc.com/) - [Gaylesta](https://directory.gaylesta.org/find-a-therapist/) (LGBTQ therapists) - [InnoPsych](https://www.innopsych.com/findatherapist) (BIPOC therapists) - [Open Path Psychotherapy Collective](https://openpathcollective.org/find-a-clinician/?address=&distance=50&n=&ethnicity=&active=undefined&remote=&age=&language=&modality=&specialties=&treatment=&pagination=0) (low-cost therapy) You can also call the Substance Abuse and Mental Health Services Administration ([SAMHSA](https://www.samhsa.gov/find-help/national-helpline)) for more resources near you at . The [National Alliance on Mental Illness](https://www.nami.org/help)(NAMI) also has a helpline you can call at [1-800-950-NAMI (6264)](tel:1-800-622-4357). ## The bottom line Depression is one of the most common mental health conditions. It will likely impact you or someone you love at some point in your life. While it may be scary or overwhelming to seek help for depression, it’s important to know that many treatment options are available. Not only are there many medications, but there are also nonmedication options and therapies that can help. Depression is treatable, and many people will achieve remission and remain symptom-free. ![why trust our exports reliability shield](https://www.grxstatic.com/images/reliability.svg) ## Why trust our experts? ![Christina Palmer, MD](https://images.ctfassets.net/4f3rgqwzdznj/5cs5SpdTHjI2wBkIJDax23/76955170a2c6475bd181a780a454b2fa/Christina_Palmer_goodrx.jpg) ![Christina Palmer, MD](https://images.ctfassets.net/4f3rgqwzdznj/5cs5SpdTHjI2wBkIJDax23/76955170a2c6475bd181a780a454b2fa/Christina_Palmer_goodrx.jpg) Written by: [Christina Palmer, MD](https://www.goodrx.com/about/bio/christina-palmer) Christina Palmer, MD, is a board-certified family physician with a focus on chronic care management, women’s health, and mental health. She’s the co-author of the book, “Open Heart: When Open-Heart Surgery Becomes Your Best Option”. ![Sophie Vergnaud, MD](https://images.ctfassets.net/4f3rgqwzdznj/5ze0VgHGfIKyEke73mUwqX/0ff278318e79489eace64865456179a3/sophie_vergnaud_goodrx.webp) ![Sophie Vergnaud, MD](https://images.ctfassets.net/4f3rgqwzdznj/5ze0VgHGfIKyEke73mUwqX/0ff278318e79489eace64865456179a3/sophie_vergnaud_goodrx.webp) Edited by: [Sophie Vergnaud, MD](https://www.goodrx.com/about/bio/sophie-vergnaud) Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology. ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) Reviewed by: [Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta) Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. ![Green trust check mark](https://www.grxstatic.com/images/green-check-mark.svg)[Our editorial standards](https://www.goodrx.com/about/editorial-guidelines) ![Green trust check mark](https://www.grxstatic.com/images/green-check-mark.svg)[Meet our experts](https://www.goodrx.com/about/health#meet-our-healthcare-experts) ## *If you or someone you know is having thoughts of suicide, you’re not alone and help is available. Call the* [*National Suicide Prevention Lifeline*](https://suicidepreventionlifeline.org/) *at* [*988*](tel:988) *or text “HOME” to* [*741-741*](sms:741-741) *to reach the* [*Crisis Text Line*](https://www.crisistextline.org/)*.* ## References Altaf, R., et al. (2021). [Folate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis](https://www.sciencedirect.com/science/article/pii/S0965229921001114). *Complementary Therapies in Medicine.* American Psychiatric Association. (2019). [Depression treatments for adults](https://www.apa.org/depression-guideline/adults). ### View All References (10) American Psychiatric Association. (2020). [What is depression?](https://www.psychiatry.org/patients-families/depression/what-is-depression) Eaton, W., et al. (2008). [Population-based study of first onset and chronicity in major depressive disorder](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/482708). *Archives of General Psychiatry.* Hasin, D. S., et al. (2018). [Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2671413). *JAMA Psychiatry.* Institute for Quality and Efficiency in Health Care. (2020). [Depression: How effective are antidepressants?](https://www.ncbi.nlm.nih.gov/books/NBK361016/) *InformedHealth.org.* Kvam, S., et al. (2016). [Exercise as a treatment for depression: A meta-analysis](http://faculty.cas.usf.edu/mbrannick/meta/CMA/Kvam2016ExerciseDepressionMeta.pdf). *Journal of Affective Disorders.* Liao, Y., et al. (2019). [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https://www.nature.com/articles/s41398-019-0515-5). *Translational Psychiatry.* National Institute of Mental Health. (2024). [Brain stimulation therapies](https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies). National Institute of Mental Health. (2024). [Psychotherapies](https://www.nimh.nih.gov/health/topics/psychotherapies). Saad Al-Harbi, K. (2012). [Treatment-resistant depression: Therapeutic trends, challenges, and future directions](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363299/). *Patient Preference and Adherence.* Sneed, A. (2022). [Can supplements really help with depression or anxiety?](https://www.nytimes.com/2022/06/13/well/mind/supplements-depression-anxiety-treatment.html) The New York Times. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines). Altaf, R., et al. (2021). [Folate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis](https://www.sciencedirect.com/science/article/pii/S0965229921001114). *Complementary Therapies in Medicine.* American Psychiatric Association. (2019). [Depression treatments for adults](https://www.apa.org/depression-guideline/adults). American Psychiatric Association. (2020). [What is depression?](https://www.psychiatry.org/patients-families/depression/what-is-depression) Eaton, W., et al. (2008). [Population-based study of first onset and chronicity in major depressive disorder](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/482708). *Archives of General Psychiatry.* Hasin, D. S., et al. (2018). [Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2671413). *JAMA Psychiatry.* Institute for Quality and Efficiency in Health Care. (2020). [Depression: How effective are antidepressants?](https://www.ncbi.nlm.nih.gov/books/NBK361016/) *InformedHealth.org.* Kvam, S., et al. (2016). [Exercise as a treatment for depression: A meta-analysis](http://faculty.cas.usf.edu/mbrannick/meta/CMA/Kvam2016ExerciseDepressionMeta.pdf). *Journal of Affective Disorders.* Liao, Y., et al. (2019). [Efficacy of omega-3 PUFAs in depression: A meta-analysis](https://www.nature.com/articles/s41398-019-0515-5). *Translational Psychiatry.* National Institute of Mental Health. (2024). [Brain stimulation therapies](https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies). National Institute of Mental Health. (2024). [Psychotherapies](https://www.nimh.nih.gov/health/topics/psychotherapies). Saad Al-Harbi, K. (2012). [Treatment-resistant depression: Therapeutic trends, challenges, and future directions](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363299/). *Patient Preference and Adherence.* Sneed, A. (2022). [Can supplements really help with depression or anxiety?](https://www.nytimes.com/2022/06/13/well/mind/supplements-depression-anxiety-treatment.html) The New York Times. ##### *For additional resources or to connect with mental health services in your area, call SAMHSA’s National Helpline at* [*1-800-662-4357*](tel:1-800-662-4357)*. For immediate assistance, call the* [*National Suicide Prevention Lifeline*](https://988lifeline.org/) *at* [*988*](tel:988)*, or text HOME to* [*741-741*](<sms: 741-741>) *to reach the* [*Crisis Text Line*](https://www.crisistextline.org/)*.* ![Newsletter Subscription](https://www.grxstatic.com/images/notification-email-female.svg) #### Subscribe and save Get prescription saving tips and more from GoodRx Health. Enter your email to sign up ### Latest articles [![Health: Health Insurance: GettyImages 674796452](https://www.grxstatic.com/4f3rgqwzdznj/6EumQkAk4hmSL7NzkJu7ph/4674bf2fa9f574891bf85c3741410daa/GettyImages-674796452.webp?w=640&q=85&fm=webp) SSRIs What Is Serotonin Syndrome? 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Readable Markdown
## Key takeaways: - Clinical depression — also known as major depressive disorder — is a common mental health condition. - There are many different treatment options for depression, including therapy and medication. - Much of the time, depression can be successfully treated. It’s important to get care if you’re experiencing symptoms. [Clinical depression](https://www.goodrx.com/conditions/depression), also called major depressive disorder or depression, is one of the most common mental health conditions in the world. It’s estimated that [1 in 5 people](https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2671413) in the U.S. will experience depression over the course of their lifetime. And when you have depression, it can affect your life in many different ways — including your physical health, your close relationships, and your job. Fortunately, treatment can help. Let’s take a closer look at medications for major depressive disorder, as well as therapy and other options. Depression is a mental health condition where you feel numb, empty, and sad most of the time. It can also make you less interested in your normal activities, and take a toll at work, at home, and in your relationships. It’s normal to [feel sad](https://www.goodrx.com/health-topic/mental-health/why-am-i-so-sad) sometimes — but major depressive disorder is much more than that. It impacts your daily life and can lead to serious symptoms like self-harm or suicide. Major depression can cause many [different symptoms](https://www.goodrx.com/conditions/depression/do-i-have-depression-signs-symptoms). These include: - Feeling sad, hopeless, or empty - Feelings of guilt or worthlessness - Loss of interest in activities you used to enjoy - Appetite changes, and weight gain or weight loss - Difficulty sleeping or sleeping more than normal - Feeling tired, or lack of energy - Physical restlessness, or feeling heavy and weighed down - Difficulty concentrating or memory problems - Having thoughts of suicide or thinking you would be better off dead To be diagnosed with depression, you need to have at least five of these symptoms, for at least 2 weeks. But in reality, depression can look different in different people. Some people experience mild depression, with fewer symptoms. Other people have more [severe depression](https://www.goodrx.com/conditions/depression/severe-depression-symptoms). And some people also have physical discomfort or pain as a result of depression. There are many medications that can help with depression. These typically include [antidepressants](https://www.goodrx.com/conditions/depression/best-antidepressant-medication), mood stabilizers, and atypical antipsychotics. You and your healthcare professional will [work together](https://www.goodrx.com/conditions/depression/major-depressive-disorder-medication) to find the right medication — or combination of medications — for your unique symptoms. Compare prices and information on the most popular Depression medications. Here are some of the options. When it comes to treating depression, [SSRIs](https://www.goodrx.com/classes/ssris/ssri-list) are a good first choice for many people. They’re also used to [treat many other](https://www.goodrx.com/health-topic/mental-health/ssris-vs-snris-differences) mental health conditions, like [anxiety disorders](https://www.goodrx.com/health-topic/anxiety-disorders) and post-traumatic stress disorder (PTSD). Examples include: [SNRIs](https://www.goodrx.com/classes/snris/snri-drugs-list) are another good first-choice medication for treating depression. Just like SSRIs, they’re also used for many other mental health conditions. And they can be helpful for some types of chronic pain, too. Options include: These are antidepressants that don’t fit well into other categories, because they work a little differently in your body. Examples include: Atypical antidepressants are often used as an add-on to other medications. But they can also work well on their own for some people. Keep in mind that esketamine is typically only used in people with suicidal thoughts, or if you have treatment-resistant depression (more on this below). TCAs are an older type of antidepressant. They’re less commonly used because they can come with more side effects than SSRIs and SNRIs. But for some people they can be a great option. Examples include: Monoamine oxidase inhibitors ([MAOIs](https://www.goodrx.com/classes/maois)) are another type of older antidepressant. Options include: Just like TCAs, they’re not usually a first-choice medication because of their side effects. You also can’t eat [certain foods](https://www.goodrx.com/classes/maois/what-is-maoi-diet) while taking them, which can be a hassle. But again — for some people, MAOIs are a good match. [Mood stabilizers](https://www.goodrx.com/classes/mood-stabilizers) and [atypical antipsychotics](https://www.goodrx.com/classes/atypical-antipsychotics) are two other types of medications that are used to treat depression. They’re often used together with antidepressants, such as SSRIs or SNRIs. Your healthcare professional might suggest adding one of these if you’re not getting enough relief from an antidepressant alone. Sometimes a medication won’t be helpful enough at first, or it may have side effects you don’t like. But it’s a good idea to give the medication enough time to see if it works for you. It may take [up to 8 weeks](https://www.ncbi.nlm.nih.gov/books/NBK361016/) for your symptoms to start getting better. It’s also worth mentioning that antidepressant medications shouldn’t be [stopped abruptly](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants). This can lead to [discontinuation symptoms](https://www.goodrx.com/classes/ssris/antidepressant-discontinuation-syndrome) like nausea, headaches, trouble sleeping, and dizziness. [Talk with your healthcare professional](https://www.goodrx.com/conditions/depression/how-to-talk-to-your-doctor-about-depression) if you’re considering stopping your medication — they can help you create a plan. And finally: Be aware that some depression medications may increase your risk for suicidal thoughts, especially in young people (children or teens). If this happens, get emergency help. Call the [National Suicide Prevention Lifeline](https://suicidepreventionlifeline.org/) at [988](tel:988) or text “HOME” to [741-741](sms:741-741) to reach the [Crisis Text Line](https://www.crisistextline.org/). Featuring [Susan Samuels, MD](https://www.goodrx.com/about/bio/undefined)Reviewed by [Sanjai Sinha, MD](https://www.goodrx.com/about/bio/sanjai-sinha) \| September 12, 2025 [Therapy](https://www.psychiatry.org/patients-families/depression/what-is-depression) can be an essential part of treatment for major depression, too — either on its own, or together with medication. Sometimes, [therapy](https://www.nimh.nih.gov/health/topics/psychotherapies) may help within just a few weeks. Or, it can take longer depending on your situation. There are [different types of therapy](https://www.apa.org/depression-guideline/adults) that can help to treat depression, including: - [Cognitive behavioral therapy](https://www.goodrx.com/health-topic/mental-health/cognitive-behavioral-therapy) (CBT) - [Interpersonal therapy](https://www.goodrx.com/health-topic/mental-health/interpersonal-therapy) (IPT) - Psychodynamic psychotherapy - Supportive therapy - Mindfulness-based cognitive therapy (MBCT) When it comes to a therapist, it’s important to find the right fit for you. There are different [ways to find a therapist](https://www.goodrx.com/health-topic/mental-health/how-to-find-a-therapist), such as searching online or asking for recommendations. You can do therapy online over video, too. In some cases, therapy may include other people. For example, family or couples therapy can often be helpful, especially if depression has affected your relationships. And group therapy can be a great way to connect with other people going through similar experiences. Treatment-resistant depression (TRD) is when your depression symptoms don’t go away completely, even after you’ve tried a couple of different medications. And it’s pretty common, too. In fact, TRD may happen in as many as [1 in 3 people](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3363299/) with depression. But having TRD doesn’t mean you’re out of [options](https://www.goodrx.com/conditions/depression/treatment-resistant-depression). It just means you might have to try a different type of treatment to get relief. Here are some of the treatments that can help if you have TRD: - **Switching to a new antidepressant:** Changing to a different type of antidepressant can help some people with TRD. - **Adding on a second or third medication:** This could mean adding another antidepressant, or an antipsychotic medication. Thyroid hormone and lithium are options for some people, too. - **Adding on therapy:** If medications haven’t worked on their own, adding on therapy can sometimes get results. - **Trying brain stimulation therapies:** These are medical procedures that [stimulate your brain](https://www.nimh.nih.gov/health/topics/brain-stimulation-therapies/brain-stimulation-therapies). Examples include transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT). - **Using esketamine and ketamine:** Esketamine (Spravato) is an FDA-approved nasal spray for treating TRD. Ketamine is a similar medication that’s often used [off-label](https://www.goodrx.com/drugs/medication-basics/off-label-drug-prescriptions) to treat depression, including TRD. - **Taking olanzapine/fluoxetine (Symbyax):** [Symbyax](https://www.goodrx.com/symbyax/what-is) is a combination medication made of two medications: olanzapine and fluoxetine. It’s also FDA-approved for treating TRD. There are also new treatments that may grow in use over time, such as [psilocybin](https://www.goodrx.com/conditions/depression/psilocybin-and-depression) (commonly known as magic mushrooms). This is a psychedelic compound that shows some promising benefits in treating depression — including TRD. But more research is needed before we can say for sure how well it works. Some over-the-counter (OTC) [supplements](https://www.nytimes.com/2022/06/13/well/mind/supplements-depression-anxiety-treatment.html) may help with depression. These include: - **St. John’s wort:** This is [an herb that may be effective for depression](https://www.goodrx.com/conditions/depression/st-johns-wort-for-depression). But it has side effects and it can interfere with other medications you’re taking. It can also be risky to mix with some prescription medications, including certain antidepressants. - **Omega-3 fatty acids:** These are [“good fats” that are important for brain health](https://www.goodrx.com/well-being/diet-nutrition/omega-3-6-9-difference-benefits). There’s some [evidence](https://www.nature.com/articles/s41398-019-0515-5) that taking omega-3 may help with depression. - **L-methylfolate or folic acid:** L-methylfolate is the active form of folic acid, a type of vitamin B. It’s not clear how well folic acid works on its own for depression, but it may be helpful as an [add-on to antidepressants](https://www.sciencedirect.com/science/article/pii/S0965229921001114). So far, there’s not enough evidence that any of these supplements work better than medications and therapy. And remember: It’s always a good idea to talk with your healthcare team before taking a new supplement. OTC supplements may have side effects, or interact with your other medications. Featuring [Jacques Ambrose, MD, MPH, FAPA](https://www.goodrx.com/about/bio/jacques-ambrose)Reviewed by [Karen Hovav, MD, FAAP](https://www.goodrx.com/about/bio/karen-hovav) \| July 2, 2025 There are some important lifestyle changes and daily habits that can help manage your depression symptoms. These include: - **Exercise:** [Exercise](http://faculty.cas.usf.edu/mbrannick/meta/CMA/Kvam2016ExerciseDepressionMeta.pdf) can help reduce depression symptoms, especially when combined with medication or therapy. Exercise doesn’t have to be complicated. Even simple things can help, like a short walk around the block or playing basketball in your driveway. - **Healthy diet:** A [nutritious diet](https://www.goodrx.com/well-being/diet-nutrition/what-is-a-healthy-diet) full of fruits and vegetables may help with depressive symptoms. It’s especially important to get enough vitamins and minerals, including vitamin B12, folate, and magnesium. - **Sleep:** Many people with depression have trouble sleeping. Working with your healthcare professional to get enough good quality sleep can help your other depression symptoms get better, too. - **Mind-body therapies:** [Mind-body activities](https://www.goodrx.com/well-being/alternative-treatments#mind-body-therapies) like yoga, tai chi, and meditation can also be helpful for people with depression. They’re also good for other things that can go hand-in-hand with depression, like pain, stress, and anxiety. - **Light therapy:** Sitting in front of a special bright [light box](https://www.goodrx.com/conditions/seasonal-affective-disorder/light-therapy-benefits) can help with some types of depression, especially [seasonal affective disorder](https://www.goodrx.com/conditions/seasonal-affective-disorder/seasonal-affective-disorder-symptoms). It’s hard to say. Technically, depression isn’t an illness that can be cured. But fortunately many people do fully recover from major depression — especially with treatment. When it comes to depression, recovery is different for everyone. It depends on many things, including: - Your symptoms - Your family history - Whether you’ve had an episode of depression before - Your overall mental and physical health - Your resources and social support For some people, depression will go away and never come back. But for other people, symptom episodes will come and go over time. In fact, at least [1 out of every 2](https://www.psychiatry.org/patients-families/depression) people will have another episode of depression sometime in their life. And the more episodes you have, the more likely it is you’ll have another one in the future. If you think you may have depression, it’s a good idea to talk with your healthcare team. You can start with your primary care provider (PCP). They might be able to get you started on medication, or provide a referral to a qualified mental health professional. If you don’t have a PCP, or aren’t sure where to start, ask friends and family for recommendations. If you’re [covered by health insurance](https://www.goodrx.com/health-topic/mental-health/therapy-without-insurance), you can also use your plan’s healthcare professional directory to look for a specialist in your area. You can also start your search for mental health professionals online. Many of them offer either in-person or telehealth appointments. Check out the following databases: You can also call the Substance Abuse and Mental Health Services Administration ([SAMHSA](https://www.samhsa.gov/find-help/national-helpline)) for more resources near you at . The [National Alliance on Mental Illness](https://www.nami.org/help)(NAMI) also has a helpline you can call at [1-800-950-NAMI (6264)](tel:1-800-622-4357). ## The bottom line Depression is one of the most common mental health conditions. It will likely impact you or someone you love at some point in your life. While it may be scary or overwhelming to seek help for depression, it’s important to know that many treatment options are available. Not only are there many medications, but there are also nonmedication options and therapies that can help. Depression is treatable, and many people will achieve remission and remain symptom-free. ![why trust our exports reliability shield](https://www.grxstatic.com/images/reliability.svg) ## Why trust our experts? ![Christina Palmer, MD](https://images.ctfassets.net/4f3rgqwzdznj/5cs5SpdTHjI2wBkIJDax23/76955170a2c6475bd181a780a454b2fa/Christina_Palmer_goodrx.jpg) ![Christina Palmer, MD](https://images.ctfassets.net/4f3rgqwzdznj/5cs5SpdTHjI2wBkIJDax23/76955170a2c6475bd181a780a454b2fa/Christina_Palmer_goodrx.jpg) Christina Palmer, MD, is a board-certified family physician with a focus on chronic care management, women’s health, and mental health. She’s the co-author of the book, “Open Heart: When Open-Heart Surgery Becomes Your Best Option”. ![Sophie Vergnaud, MD](https://images.ctfassets.net/4f3rgqwzdznj/5ze0VgHGfIKyEke73mUwqX/0ff278318e79489eace64865456179a3/sophie_vergnaud_goodrx.webp) ![Sophie Vergnaud, MD](https://images.ctfassets.net/4f3rgqwzdznj/5ze0VgHGfIKyEke73mUwqX/0ff278318e79489eace64865456179a3/sophie_vergnaud_goodrx.webp) Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology. ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. *If you or someone you know is having thoughts of suicide, you’re not alone and help is available. Call the* [*National Suicide Prevention Lifeline*](https://suicidepreventionlifeline.org/) *at* [*988*](tel:988) *or text “HOME” to* [*741-741*](sms:741-741) *to reach the* [*Crisis Text Line*](https://www.crisistextline.org/)*.* GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines).
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