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| Meta Title | Depression Medications - Prices for Brand and Generic Depression Drugs - GoodRx |
| Meta Description | Find the most popular and affordable Depression medication. Save with or without insurance on brand and generic alternatives used to treat Depression. |
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| Boilerpipe Text | Viewing 25 of 54 medications
Featured offer
Exclusive discount
Desvenlafaxine
(Pristiq) is an expensive drug used to treat
depression
. This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Escitalopram
(Lexapro) is an inexpensive drug used to treat
depression
and certain types of
anxiety
. This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Bupropion XL
(
Wellbutrin
XL) is a moderately priced drug used to treat
depression
. This drug is slightly more popular than comparable drugs. It is available in brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Trazodone is an inexpensive drug used to treat
depression
. This drug is more popular than comparable drugs. Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Duloxetine
(Cymbalta) is a moderately priced drug used to treat
depression
,
anxiety
,
fibromyalgia
, and nerve
pain
associated with
diabetes
(
diabetic peripheral neuropathy
). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. The most common version of Cymbalta is covered by 62% of insurance plans at a co-pay of $60.00-$87.50, however, some pharmacy coupons or cash prices may be lower.
Aripiprazole
(Abilify) is an inexpensive drug used to treat
schizophrenia
and
bipolar disorder
, also known as
manic-depression
. It is also used to treat
Tourette's disorder
and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat
major depressive disorder
. This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Amitriptyline is used to treat
depression
. It is more popular than comparable drugs. Amitriptyline is only available as a generic drug; all brands have been discontinued. Generic amitriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Mirtazapine
(Remeron) is an inexpensive drug used to treat
depression
. It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic mirtazapine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Citalopram
(Celexa) is an inexpensive drug used to treat
depression
. It is slightly less popular than comparable drugs. This drug is available in generic and brand versions. Generic citalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may lower.
BUPROPION treats
depression
. It increases norepinephrine and dopamine in the brain, hormones that help regulate mood. It belongs to a group of medications called NDRIs.
Nortriptyline
(Pamelor) is an inexpensive drug used to treat
depression
. It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic nortriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Sponsored savings card
Subject to eligibility
Trintellix (vortioxetine) is used to treat
depression
. Trintellix is an
atypical antidepressant
which works by balancing out cetain chemicals like dopamine and norepinephrine. The most common form of Trintellix is a 10mg tablet. It is also available as a 5mg tablet and a 20mg tablet. There are currently no generic alterantives for Trintellix. It is covered by some Medicare and insurance plans, but some pharmacy coupons, manufacturer programs, or cash prices may be lower.
DOXEPIN reduces
itching
caused by skin conditions, such as
eczema
. It works by blocking histamine, a substance released by the body during an
allergic reaction
.
QUETIAPINE
treats
schizophrenia
and
bipolar disorder
. It may also be used with antidepressant medication to treat
depression
. It works by balancing the levels of dopamine and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It belongs to a group of medications called antipsychotics. Antipsychotic medications can be used to treat several kinds of mental health conditions.
Venlafaxine is an inexpensive drug used to treat
depression
. It works by increasing the amount of serotonin and norepinephrine available in the brain. It is slightly less popular than comparable drugs. Venlafaxine is only available as a generic drug; all brands have been discontinued. Generic venlafaxine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Bupropion SR
(
Wellbutrin
SR) is used to treat
depression
. It is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic
bupropion
sr is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
AMOXAPINE treats
depression
. It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called
tricyclic antidepressants
(
TCAs
).
Nardil (
Phenelzine
) is a moderately priced
monoamine oxidase inhibitor
(
MAOI
). It is used to treat
depression
in patients who may also have
anxiety
. This medicine is usually only used when other medicines have not helped. It is less popular than comparable drugs. There is currently no generic alternative to Nardil. The most common version of Nardil is covered by 75% of insurance plans at a co-pay of $60.00-$80.00, however, some pharmacy coupons or cash prices may be lower.
PERPHENAZINE
;
AMITRIPTYLINE
treats
depression
and
anxiety
. It may also be used to treat
schizophrenia
. It works by increasing levels of dopamine, norepinephrine, and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It is a combination of an antipsychotic and a
tricyclic antidepressant
(
TCA
). Antipsychotic medications can be used to treat several kinds of mental health conditions.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions. |
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3. [Depression](https://www.goodrx.com/conditions/depression)
# Depression Medications
## Find prices and information on Depression medications.
Read our guide to[Depression](https://www.goodrx.com/conditions/depression)

## Key takeaways
Medications for depression help balance chemicals in the brain to improve your mood. There are several common classes of antidepressants. iSelective serotonin reuptake inhibitors (SSRIs) include [fluoxetine](https://www.goodrx.com/prozac/what-is) (Prozac) and [sertraline](https://www.goodrx.com/zoloft/what-is) (Zoloft). Serotonin-norepinephrine reuptake inhibitors (SNRIs) include [duloxetine](https://www.goodrx.com/cymbalta/what-is) (Cymbalta) and [venlafaxine](https://www.goodrx.com/venlafaxine/what-is) (Effexor XR). Atypical antidepressants include [bupropion](https://www.goodrx.com/bupropion/what-is) (Wellbutrin XL) and [trazodone](https://www.goodrx.com/trazodone/what-is). Tricyclic antidepressants (TCAs) include [amitriptyline](https://www.goodrx.com/amitriptyline/what-is) and [nortriptyline](https://www.goodrx.com/nortriptyline/what-is). And monoamine oxidase inhibitors (MAOIs) include [selegiline](https://www.goodrx.com/selegiline/what-is) and [phenelzine](https://www.goodrx.com/phenelzine/what-is) (Nardil). These medications provide a variety of options for treating depression symptoms.
Show less
Prices for popular Depression medications
Viewing 25 of 54 medications
Popularity
Featured offer
Exclusive discount

## [Pristiq (desvenlafaxine succinate ER)](https://www.goodrx.com/pristiq)
as low as[\$200](https://www.goodrx.com/pristiq)
View other[SNRIs](https://www.goodrx.com/classes/snris)
[Desvenlafaxine](https://www.goodrx.com/desvenlafaxine-er) (Pristiq) is an expensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/pristiq)[More info](https://www.goodrx.com/pristiq/what-is)

## [Lexapro (escitalopram)](https://www.goodrx.com/lexapro)
as low as[\$9](https://www.goodrx.com/lexapro)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[Escitalopram](https://www.goodrx.com/escitalopram) (Lexapro) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression) and certain types of [anxiety](https://www.goodrx.com/conditions/anxiety). This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/lexapro)[More info](https://www.goodrx.com/lexapro/what-is)

## [Prozac (fluoxetine)](https://www.goodrx.com/prozac)
as low as[\$9](https://www.goodrx.com/prozac)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[Fluoxetine](https://www.goodrx.com/fluoxetine) (Prozac) is an inexpensive drug used to treat mood problems such as [depression](https://www.goodrx.com/conditions/depression), [obsessive compulsive disorder](https://www.goodrx.com/conditions/obsessive-compulsive-disorder), and [panic attacks](https://www.goodrx.com/conditions/panic-disorder). It can also treat certain [eating disorders](https://www.goodrx.com/conditions/eating-disorders). It is available in generic and brand versions. Generic fluoxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/prozac)[More info](https://www.goodrx.com/prozac/what-is)

## [Zoloft (sertraline)](https://www.goodrx.com/zoloft)
as low as[\$9](https://www.goodrx.com/zoloft)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[Sertraline](https://www.goodrx.com/sertraline) (Zoloft) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It may also be used to treat [obsessive compulsive disorder](https://www.goodrx.com/conditions/obsessive-compulsive-disorder), [panic disorder](https://www.goodrx.com/conditions/panic-disorder), post-trauma stress, [premenstrual dysphoric disorder](https://www.goodrx.com/conditions/pmdd) ([PMDD](https://www.goodrx.com/conditions/pmdd)), or social [anxiety](https://www.goodrx.com/conditions/anxiety). It is more popular than comparable drugs. Generic sertraline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/zoloft)[More info](https://www.goodrx.com/zoloft/what-is)

## [Wellbutrin XL (bupropion XL)](https://www.goodrx.com/wellbutrin-xl)
as low as[\$14](https://www.goodrx.com/wellbutrin-xl)
View other[Atypical Antidepressants](https://www.goodrx.com/classes/atypical-antidepressants)
[Bupropion XL](https://www.goodrx.com/bupropion-xl) ([Wellbutrin](https://www.goodrx.com/wellbutrin) XL) is a moderately priced drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is slightly more popular than comparable drugs. It is available in brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/wellbutrin-xl)[More info](https://www.goodrx.com/wellbutrin-xl/what-is)

## [trazodone](https://www.goodrx.com/trazodone)
as low as[\$9](https://www.goodrx.com/trazodone)
View other[Atypical Antidepressants](https://www.goodrx.com/classes/atypical-antidepressants)
Trazodone is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is more popular than comparable drugs. Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/trazodone)[More info](https://www.goodrx.com/trazodone/what-is)

## [Cymbalta (duloxetine)](https://www.goodrx.com/cymbalta)
as low as[\$12](https://www.goodrx.com/cymbalta)
View other[SNRIs](https://www.goodrx.com/classes/snris)
[Duloxetine](https://www.goodrx.com/duloxetine) (Cymbalta) is a moderately priced drug used to treat [depression](https://www.goodrx.com/conditions/depression), [anxiety](https://www.goodrx.com/conditions/anxiety), [fibromyalgia](https://www.goodrx.com/conditions/fibromyalgia), and nerve [pain](https://www.goodrx.com/conditions/pain) associated with [diabetes](https://www.goodrx.com/conditions/diabetes-type-2) ([diabetic peripheral neuropathy](https://www.goodrx.com/conditions/diabetic-neuropathy)). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. The most common version of Cymbalta is covered by 62% of insurance plans at a co-pay of \$60.00-\$87.50, however, some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/cymbalta)[More info](https://www.goodrx.com/cymbalta/what-is)

## [Abilify (aripiprazole)](https://www.goodrx.com/abilify)
as low as[\$13](https://www.goodrx.com/abilify)
View other[Atypical Antipsychotics](https://www.goodrx.com/classes/atypical-antipsychotics)
[Aripiprazole](https://www.goodrx.com/aripiprazole) (Abilify) is an inexpensive drug used to treat [schizophrenia](https://www.goodrx.com/conditions/schizophrenia) and [bipolar disorder](https://www.goodrx.com/conditions/bipolar-disorder), also known as [manic-depression](https://www.goodrx.com/conditions/bipolar-disorder). It is also used to treat [Tourette's disorder](https://www.goodrx.com/conditions/tourette-syndrome) and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat [major depressive disorder](https://www.goodrx.com/conditions/depression). This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/abilify)[More info](https://www.goodrx.com/abilify/what-is)

## [Effexor XR (venlafaxine ER)](https://www.goodrx.com/effexor-xr)
as low as[\$13](https://www.goodrx.com/effexor-xr)
View other[SNRIs](https://www.goodrx.com/classes/snris)
[Venlafaxine ER](https://www.goodrx.com/venlafaxine-er) ([Effexor](https://www.goodrx.com/effexor) XR) is a moderately priced drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is also used to treat [general anxiety disorder](https://www.goodrx.com/conditions/anxiety), social [anxiety disorder](https://www.goodrx.com/conditions/anxiety), and [panic disorder](https://www.goodrx.com/conditions/panic-disorder). This drug is slightly more popular than comparable drugs. It is available in brand and generic form. Generic [venlafaxine](https://www.goodrx.com/venlafaxine) ER is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/effexor-xr)[More info](https://www.goodrx.com/effexor-xr/what-is)

## [amitriptyline](https://www.goodrx.com/amitriptyline)
as low as[\$4](https://www.goodrx.com/amitriptyline)
View other[Tricyclic Antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants)
Amitriptyline is used to treat [depression](https://www.goodrx.com/conditions/depression). It is more popular than comparable drugs. Amitriptyline is only available as a generic drug; all brands have been discontinued. Generic amitriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/amitriptyline)[More info](https://www.goodrx.com/amitriptyline/what-is)

## [Remeron (mirtazapine)](https://www.goodrx.com/remeron)
as low as[\$10](https://www.goodrx.com/remeron)
View other[Tetracyclic Antidepressants](https://www.goodrx.com/classes/tetracyclic-antidepressants)
[Mirtazapine](https://www.goodrx.com/mirtazapine) (Remeron) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic mirtazapine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/remeron)[More info](https://www.goodrx.com/remeron/what-is)

## [Celexa (citalopram)](https://www.goodrx.com/celexa)
as low as[\$14](https://www.goodrx.com/celexa)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[Citalopram](https://www.goodrx.com/citalopram) (Celexa) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. This drug is available in generic and brand versions. Generic citalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may lower.
[See prices](https://www.goodrx.com/celexa)[More info](https://www.goodrx.com/celexa/what-is)

## [Paxil (paroxetine)](https://www.goodrx.com/paxil)
as low as[\$16](https://www.goodrx.com/paxil)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[Paroxetine](https://www.goodrx.com/paroxetine) (Paxil, [Brisdelle](https://www.goodrx.com/brisdelle)) is used to treat [depression](https://www.goodrx.com/conditions/depression). It may also be used to treat [anxiety disorders](https://www.goodrx.com/conditions/anxiety), [obsessive compulsive disorder](https://www.goodrx.com/conditions/obsessive-compulsive-disorder), [panic attacks](https://www.goodrx.com/conditions/panic-disorder), post traumatic stress, and [premenstrual dysphoric disorder](https://www.goodrx.com/conditions/pmdd) ([PMDD](https://www.goodrx.com/conditions/pmdd)). It is slightly more popular than comparable drugs. It is available in generic and brand versions. Generic paroxetine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/paxil)[More info](https://www.goodrx.com/paxil/what-is)

## [bupropion](https://www.goodrx.com/bupropion)
as low as[\$8](https://www.goodrx.com/bupropion)
View other[Atypical Antidepressants](https://www.goodrx.com/classes/atypical-antidepressants)
BUPROPION treats [depression](https://www.goodrx.com/conditions/depression). It increases norepinephrine and dopamine in the brain, hormones that help regulate mood. It belongs to a group of medications called NDRIs.
[See prices](https://www.goodrx.com/bupropion)[More info](https://www.goodrx.com/bupropion/what-is)

## [Pamelor (nortriptyline)](https://www.goodrx.com/pamelor)
as low as[\$10](https://www.goodrx.com/pamelor)
View other[Tricyclic Antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants)
[Nortriptyline](https://www.goodrx.com/nortriptyline) (Pamelor) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic nortriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/pamelor)[More info](https://www.goodrx.com/pamelor/what-is)
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## [Trintellix](https://www.goodrx.com/trintellix)
as low as[\$10](https://www.goodrx.com/trintellix)
View other[Atypical Antidepressants](https://www.goodrx.com/classes/atypical-antidepressants)
Trintellix (vortioxetine) is used to treat [depression](https://www.goodrx.com/conditions/depression). Trintellix is an [atypical antidepressant](https://www.goodrx.com/classes/atypical-antidepressants) which works by balancing out cetain chemicals like dopamine and norepinephrine. The most common form of Trintellix is a 10mg tablet. It is also available as a 5mg tablet and a 20mg tablet. There are currently no generic alterantives for Trintellix. It is covered by some Medicare and insurance plans, but some pharmacy coupons, manufacturer programs, or cash prices may be lower.
[See prices](https://www.goodrx.com/trintellix)[More info](https://www.goodrx.com/trintellix/what-is)

## [doxepin](https://www.goodrx.com/doxepin)
as low as[\$11](https://www.goodrx.com/doxepin)
View other[Tricyclic Antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants)
DOXEPIN reduces [itching](https://www.goodrx.com/conditions/itching) caused by skin conditions, such as [eczema](https://www.goodrx.com/conditions/eczema). It works by blocking histamine, a substance released by the body during an [allergic reaction](https://www.goodrx.com/conditions/anaphylaxis).
[See prices](https://www.goodrx.com/doxepin)[More info](https://www.goodrx.com/doxepin/what-is)

## [Seroquel XR (quetiapine ER)](https://www.goodrx.com/seroquel-xr)
as low as[\$12](https://www.goodrx.com/seroquel-xr)
View other[Atypical Antipsychotics](https://www.goodrx.com/classes/atypical-antipsychotics)
[QUETIAPINE](https://www.goodrx.com/quetiapine) treats [schizophrenia](https://www.goodrx.com/conditions/schizophrenia) and [bipolar disorder](https://www.goodrx.com/conditions/bipolar-disorder). It may also be used with antidepressant medication to treat [depression](https://www.goodrx.com/conditions/depression). It works by balancing the levels of dopamine and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It belongs to a group of medications called antipsychotics. Antipsychotic medications can be used to treat several kinds of mental health conditions.
[See prices](https://www.goodrx.com/seroquel-xr)[More info](https://www.goodrx.com/seroquel-xr/what-is)

## [venlafaxine](https://www.goodrx.com/venlafaxine)
as low as[\$12](https://www.goodrx.com/venlafaxine)
View other[SNRIs](https://www.goodrx.com/classes/snris)
Venlafaxine is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It works by increasing the amount of serotonin and norepinephrine available in the brain. It is slightly less popular than comparable drugs. Venlafaxine is only available as a generic drug; all brands have been discontinued. Generic venlafaxine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/venlafaxine)[More info](https://www.goodrx.com/venlafaxine/what-is)

## [Wellbutrin SR (bupropion SR)](https://www.goodrx.com/wellbutrin-sr)
as low as[\$15](https://www.goodrx.com/wellbutrin-sr)
View other[Atypical Antidepressants](https://www.goodrx.com/classes/atypical-antidepressants)
[Bupropion SR](https://www.goodrx.com/bupropion-sr) ([Wellbutrin](https://www.goodrx.com/wellbutrin) SR) is used to treat [depression](https://www.goodrx.com/conditions/depression). It is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic [bupropion](https://www.goodrx.com/bupropion) sr is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/wellbutrin-sr)[More info](https://www.goodrx.com/wellbutrin-sr/what-is)

## [amoxapine](https://www.goodrx.com/amoxapine)
as low as[\$19](https://www.goodrx.com/amoxapine)
View other[Tricyclic Antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants)
AMOXAPINE treats [depression](https://www.goodrx.com/conditions/depression). It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called [tricyclic antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants) ([TCAs](https://www.goodrx.com/classes/tricyclic-antidepressants)).
[See prices](https://www.goodrx.com/amoxapine)[More info](https://www.goodrx.com/amoxapine/what-is)

## [chlordiazepoxide / amitriptyline](https://www.goodrx.com/chlordiazepoxide-amitriptyline)
as low as[\$19](https://www.goodrx.com/chlordiazepoxide-amitriptyline)
View other[Benzodiazepine / Tricyclic Antidepressant Combinations](https://www.goodrx.com/classes/benzodiazepine-tricyclic-antidepressant-combinations)
[CHLORDIAZEPOXIDE](https://www.goodrx.com/chlordiazepoxide); [AMITRIPTYLINE](https://www.goodrx.com/amitriptyline) treats [depression](https://www.goodrx.com/conditions/depression) and [anxiety](https://www.goodrx.com/conditions/anxiety). It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It also works by helping your nervous system calm down. It is a combination of a [tricyclic antidepressant](https://www.goodrx.com/classes/tricyclic-antidepressants) ([TCA](https://www.goodrx.com/classes/tricyclic-antidepressants)) and a [benzodiazepine](https://www.goodrx.com/classes/benzodiazepines).
[See prices](https://www.goodrx.com/chlordiazepoxide-amitriptyline)[More info](https://www.goodrx.com/chlordiazepoxide-amitriptyline/what-is)

## [Paxil CR (paroxetine ER)](https://www.goodrx.com/paxil-cr)
as low as[\$32](https://www.goodrx.com/paxil-cr)
View other[SSRIs](https://www.goodrx.com/classes/ssris)
[PAROXETINE](https://www.goodrx.com/paroxetine) treats [depression](https://www.goodrx.com/conditions/depression), [anxiety](https://www.goodrx.com/conditions/anxiety), [obsessive-compulsive disorder](https://www.goodrx.com/conditions/obsessive-compulsive-disorder) ([OCD](https://www.goodrx.com/conditions/obsessive-compulsive-disorder)), [post-traumatic stress disorder](https://www.goodrx.com/conditions/ptsd) ([PTSD](https://www.goodrx.com/conditions/ptsd)), and [premenstrual dysphoric disorder](https://www.goodrx.com/conditions/pmdd) ([PMDD](https://www.goodrx.com/conditions/pmdd)). It increases the amount of serotonin in the brain, a hormone that helps regulate mood. It belongs to a group of medications called [SSRIs](https://www.goodrx.com/classes/ssris).
[See prices](https://www.goodrx.com/paxil-cr)[More info](https://www.goodrx.com/paxil-cr/what-is)

## [Nardil (phenelzine)](https://www.goodrx.com/nardil)
as low as[\$61](https://www.goodrx.com/nardil)
View other[MAOIs](https://www.goodrx.com/classes/maois)
Nardil ([Phenelzine](https://www.goodrx.com/phenelzine)) is a moderately priced [monoamine oxidase inhibitor](https://www.goodrx.com/classes/maois) ([MAOI](https://www.goodrx.com/classes/maois)). It is used to treat [depression](https://www.goodrx.com/conditions/depression) in patients who may also have [anxiety](https://www.goodrx.com/conditions/anxiety). This medicine is usually only used when other medicines have not helped. It is less popular than comparable drugs. There is currently no generic alternative to Nardil. The most common version of Nardil is covered by 75% of insurance plans at a co-pay of \$60.00-\$80.00, however, some pharmacy coupons or cash prices may be lower.
[See prices](https://www.goodrx.com/nardil)[More info](https://www.goodrx.com/nardil/what-is)

## [perphenazine / amitriptyline](https://www.goodrx.com/perphenazine-amitriptyline)
as low as[\$62](https://www.goodrx.com/perphenazine-amitriptyline)
View other[Typical Antipsychotic / Tricyclic Antidepressant Combinations](https://www.goodrx.com/classes/typical-antipsychotic-tricyclic-antidepressant-combinations)
[PERPHENAZINE](https://www.goodrx.com/perphenazine); [AMITRIPTYLINE](https://www.goodrx.com/amitriptyline) treats [depression](https://www.goodrx.com/conditions/depression) and [anxiety](https://www.goodrx.com/conditions/anxiety). It may also be used to treat [schizophrenia](https://www.goodrx.com/conditions/schizophrenia). It works by increasing levels of dopamine, norepinephrine, and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It is a combination of an antipsychotic and a [tricyclic antidepressant](https://www.goodrx.com/classes/tricyclic-antidepressants) ([TCA](https://www.goodrx.com/classes/tricyclic-antidepressants)). Antipsychotic medications can be used to treat several kinds of mental health conditions.
[See prices](https://www.goodrx.com/perphenazine-amitriptyline)[More info](https://www.goodrx.com/perphenazine-amitriptyline/what-is)
View all (54)
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions.
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[ Drugs for Men: A GoodRx Savings Guide to 7 Notable Men’s Health Medications Joshua Murdock, PharmD, BCBBSUpdated on Feb 2, 2026](https://www.goodrx.com/health-topic/mens-health/common-medications-for-men)
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[ What To Do Before And After Spravato Treatment: 8 Tips for Using Spravato Safely Jill Barat, PharmDUpdated on Dec 18, 2025](https://www.goodrx.com/spravato/how-to-get-the-most-from-spravato)
[ The 8 Best Supplements for Depression Nicole Andonian, MDPublished on Dec 10, 2025](https://www.goodrx.com/conditions/depression/natural-remedies-for-depression)
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[  What Are the Common Signs and Symptoms of Depression? Updated on Oct 29, 2025 3:04](https://www.goodrx.com/conditions/depression/do-i-have-depression-signs-symptoms)
[ How to Cope With Postpartum Depression Sarah Gupta, MDUpdated on Oct 22, 2025](https://www.goodrx.com/conditions/postpartum-depression/postpartum-depression-how-to-overcome)
[ Should You Try SAD Light Therapy? Eric Patterson, LPCUpdated on Oct 22, 2025](https://www.goodrx.com/conditions/seasonal-affective-disorder/light-therapy-benefits)
[ What Pharmacists Say About the Best Time to Take Wellbutrin (Plus 6 More Tips) Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMPUpdated on Oct 9, 2025](https://www.goodrx.com/wellbutrin/best-time-take-wellbutrin-tips)
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| Readable Markdown | Viewing 25 of 54 medications
Featured offer
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[Desvenlafaxine](https://www.goodrx.com/desvenlafaxine-er) (Pristiq) is an expensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is slightly less popular than comparable drugs. A generic form of Pristiq may become available in 2022. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Escitalopram](https://www.goodrx.com/escitalopram) (Lexapro) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression) and certain types of [anxiety](https://www.goodrx.com/conditions/anxiety). This drug is slightly more popular than comparable drugs. As of 2006, it is available in generic and brand versions. Generic escitalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Bupropion XL](https://www.goodrx.com/bupropion-xl) ([Wellbutrin](https://www.goodrx.com/wellbutrin) XL) is a moderately priced drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is slightly more popular than comparable drugs. It is available in brand and generic forms. It is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Trazodone is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). This drug is more popular than comparable drugs. Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Duloxetine](https://www.goodrx.com/duloxetine) (Cymbalta) is a moderately priced drug used to treat [depression](https://www.goodrx.com/conditions/depression), [anxiety](https://www.goodrx.com/conditions/anxiety), [fibromyalgia](https://www.goodrx.com/conditions/fibromyalgia), and nerve [pain](https://www.goodrx.com/conditions/pain) associated with [diabetes](https://www.goodrx.com/conditions/diabetes-type-2) ([diabetic peripheral neuropathy](https://www.goodrx.com/conditions/diabetic-neuropathy)). It is more popular than comparable drugs. As of 2013, it is available in generic and brand versions. The most common version of Cymbalta is covered by 62% of insurance plans at a co-pay of \$60.00-\$87.50, however, some pharmacy coupons or cash prices may be lower.
[Aripiprazole](https://www.goodrx.com/aripiprazole) (Abilify) is an inexpensive drug used to treat [schizophrenia](https://www.goodrx.com/conditions/schizophrenia) and [bipolar disorder](https://www.goodrx.com/conditions/bipolar-disorder), also known as [manic-depression](https://www.goodrx.com/conditions/bipolar-disorder). It is also used to treat [Tourette's disorder](https://www.goodrx.com/conditions/tourette-syndrome) and some symptoms of autism. This medicine may also be used in combination with antidepressants to treat [major depressive disorder](https://www.goodrx.com/conditions/depression). This drug is slightly more popular than comparable drugs. It is available in brand and generic versions. Generic aripiprazole is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
Amitriptyline is used to treat [depression](https://www.goodrx.com/conditions/depression). It is more popular than comparable drugs. Amitriptyline is only available as a generic drug; all brands have been discontinued. Generic amitriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Mirtazapine](https://www.goodrx.com/mirtazapine) (Remeron) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic mirtazapine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Citalopram](https://www.goodrx.com/citalopram) (Celexa) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. This drug is available in generic and brand versions. Generic citalopram is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may lower.
BUPROPION treats [depression](https://www.goodrx.com/conditions/depression). It increases norepinephrine and dopamine in the brain, hormones that help regulate mood. It belongs to a group of medications called NDRIs.
[Nortriptyline](https://www.goodrx.com/nortriptyline) (Pamelor) is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It is slightly less popular than comparable drugs. It is available in generic and brand versions. Generic nortriptyline is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
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Trintellix (vortioxetine) is used to treat [depression](https://www.goodrx.com/conditions/depression). Trintellix is an [atypical antidepressant](https://www.goodrx.com/classes/atypical-antidepressants) which works by balancing out cetain chemicals like dopamine and norepinephrine. The most common form of Trintellix is a 10mg tablet. It is also available as a 5mg tablet and a 20mg tablet. There are currently no generic alterantives for Trintellix. It is covered by some Medicare and insurance plans, but some pharmacy coupons, manufacturer programs, or cash prices may be lower.
DOXEPIN reduces [itching](https://www.goodrx.com/conditions/itching) caused by skin conditions, such as [eczema](https://www.goodrx.com/conditions/eczema). It works by blocking histamine, a substance released by the body during an [allergic reaction](https://www.goodrx.com/conditions/anaphylaxis).
[QUETIAPINE](https://www.goodrx.com/quetiapine) treats [schizophrenia](https://www.goodrx.com/conditions/schizophrenia) and [bipolar disorder](https://www.goodrx.com/conditions/bipolar-disorder). It may also be used with antidepressant medication to treat [depression](https://www.goodrx.com/conditions/depression). It works by balancing the levels of dopamine and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It belongs to a group of medications called antipsychotics. Antipsychotic medications can be used to treat several kinds of mental health conditions.
Venlafaxine is an inexpensive drug used to treat [depression](https://www.goodrx.com/conditions/depression). It works by increasing the amount of serotonin and norepinephrine available in the brain. It is slightly less popular than comparable drugs. Venlafaxine is only available as a generic drug; all brands have been discontinued. Generic venlafaxine is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
[Bupropion SR](https://www.goodrx.com/bupropion-sr) ([Wellbutrin](https://www.goodrx.com/wellbutrin) SR) is used to treat [depression](https://www.goodrx.com/conditions/depression). It is more popular than comparable drugs. It is available in multiple generic and brand versions. Generic [bupropion](https://www.goodrx.com/bupropion) sr is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower.
AMOXAPINE treats [depression](https://www.goodrx.com/conditions/depression). It increases the amount of serotonin and norepinephrine in the brain, substances that help regulate mood. It belongs to a group of medications called [tricyclic antidepressants](https://www.goodrx.com/classes/tricyclic-antidepressants) ([TCAs](https://www.goodrx.com/classes/tricyclic-antidepressants)).
Nardil ([Phenelzine](https://www.goodrx.com/phenelzine)) is a moderately priced [monoamine oxidase inhibitor](https://www.goodrx.com/classes/maois) ([MAOI](https://www.goodrx.com/classes/maois)). It is used to treat [depression](https://www.goodrx.com/conditions/depression) in patients who may also have [anxiety](https://www.goodrx.com/conditions/anxiety). This medicine is usually only used when other medicines have not helped. It is less popular than comparable drugs. There is currently no generic alternative to Nardil. The most common version of Nardil is covered by 75% of insurance plans at a co-pay of \$60.00-\$80.00, however, some pharmacy coupons or cash prices may be lower.
[PERPHENAZINE](https://www.goodrx.com/perphenazine); [AMITRIPTYLINE](https://www.goodrx.com/amitriptyline) treats [depression](https://www.goodrx.com/conditions/depression) and [anxiety](https://www.goodrx.com/conditions/anxiety). It may also be used to treat [schizophrenia](https://www.goodrx.com/conditions/schizophrenia). It works by increasing levels of dopamine, norepinephrine, and serotonin in your brain, substances that help regulate mood, behaviors, and thoughts. It is a combination of an antipsychotic and a [tricyclic antidepressant](https://www.goodrx.com/classes/tricyclic-antidepressants) ([TCA](https://www.goodrx.com/classes/tricyclic-antidepressants)). Antipsychotic medications can be used to treat several kinds of mental health conditions.
Disclaimer: Popularity is based on total prescriptions for the brand and generic versions of each drug, regardless of the condition being treated. Some drugs are prescribed for multiple conditions. |
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