🕷️ Crawler Inspector

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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 61 (from laksa055)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa061.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.goodrx.com/classes/ssris/ssri-list\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.goodrx.com/classes/ssris/ssri-list\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list","crawl_time":1775047796,"first_indexed_time":1678480057,"http_code":200,"src_unparsed":"com,goodrx!www,\/classes\/ssris\/ssri-list s443","src_root_hash":"16240351626176129661","history_drop_reason":null,"meta_title":"List of 7 SSRIs (Selective Serotonin Reuptake Inhibitors) - GoodRx","meta_descriptions":["Selective serotonin reuptake inhibitors (SSRIs) are a first-line treatment for anxiety and depression. See a list of SSRIs and their differences to make the best choice for you."],"attrs_boilerpipe_text":"Key takeaways:\nSelective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil).\nYour medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you.\nThere are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription\nmore affordable\n.\nSelective serotonin reuptake inhibitors (SSRIs)\nare a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re\nthought to work\nby increasing availability of a chemical in the brain called\nserotonin\n. Common examples of SSRIs include\nfluoxetine\n(Prozac),\nsertraline\n(Zoloft), and\nparoxetine\n(Paxil).\nBut with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs.\nFluoxetine (Prozac) was\napproved in 1987\n, making it the oldest SSRI available in the U.S. It’s\napproved to treat:\nFluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The\nDR capsules\n, which can be taken once weekly, are only approved to treat MDD.\nSide effects:\nSSRIs can make some people feel\ndrowsy\n. But fluoxetine can be more “\nactivating\n,” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take\nyour dose\nin the morning. Fluoxetine also\nsticks around longer\nin your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called\ndiscontinuation syndrome\n).\nInteractions:\nFluoxetine can\ninterfere with\nhow your body breaks down other medications, resulting in several\nsignificant interactions\n. And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose.\nUse in pregnancy:\nSSRIs are generally considered the\nsafer antidepressant options\nto take during pregnancy. But fluoxetine\nhas been linked\nto an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant.\nSertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for:\nRead more like this\nExplore these related articles, suggested for readers like you.\nView more\nSertraline is\navailable as\ntablets, capsules, and an oral solution.\nSide effects\n: Sertraline may be more likely to\ncause diarrhea\nthan other SSRIs, though this usually goes away within a few weeks. \nUse during pregnancy\n: Of the SSRs, sertraline may be\none of the safest\nto take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation.\nParoxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension.\nPexeva is another\nform of paroxetine\nthat’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet.\nBrisdelle\nis a lower-dose paroxetine capsule that’s specifically approved to\ntreat hot flashes\nin menopausal women.\nSide effects\n: Paroxetine tends to cause\nmore side effects\nthan other SSRIs. These can include\nweight gain\n,\nsexual side effects\n, and drowsiness. Paxil is also\nmore likely\nto cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you\nstop taking it\ntoo quickly. But side effects like weight gain and decreased libido\nmay be less likely\nif you’re taking Brisdelle.\nInteractions:\nParoxetine has several of the\nsame interactions\nas fluoxetine. And unlike other SSRIs, paroxetine can\nbuild up in your body\nif you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower\ndosage\n.\nUse during pregnancy\n: Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But\nseveral birth defects\nhave been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment.\nCitalopram\n(Celexa) is only approved to treat depression. But it’s used off-label to treat\nseveral other\nmental health conditions. It’s available as a tablet, capsule, and oral solution.\nSide effects:\nCompared to other SSRIs, citalopram is associated with a\nhigher risk\nof abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking\ncertain medications\nthat interact with citalopram.\nInteractions:\nCompared to other SSRIs, citalopram may be\nless likely\nto interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above,\ninteractions are still possible\n.\nEscitalopram\n(Lexapro) is approved to treat MDD and\ngeneralized anxiety disorder\n(GAD). It’s available as a tablet and oral solution.\nEscitalopram and citalopram\nare similar, but they’re\nnot the same\n. Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also\nmore specific\nto serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram.\nSide effects\n: Escitalopram may also have a risk of abnormal heart rhythms, especially if you\ntake doses\nthat are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram.\nInteractions:\nSimilar to citalopram, escitalopram may have fewer interactions than other SSRIs.\nFluvoxamine\n(Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules.\nSide effects\n: All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these\nside effects\nmore often. And in some clinical studies, more people\nstopped taking fluvoxamine\ndue to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly.\nInteractions:\nFluvoxamine also has an\nincreased risk\nof interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can\ninterfere with\nhow caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it.\nVilazodone\n(Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD. \nVilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants.\nResearchers do think\nthis difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure.\nHow you take it:\nTaking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone\nshould be\ntaken with food. If you take it on an empty stomach, it may not work as well.\nThe best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider. \nA few considerations may include:\nCan you swallow pills?\nIf you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions.\nDo you take other medications?\nCertain SSRIs, including paroxetine and fluoxetine, have a higher\nrisk of interactions\n. If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred.\nDo you have any other health conditions?\nYour medical history could also influence your choice of SSRI. For example, citalopram\nmay be avoided\nif you’ve recently had a heart attack.\nAre you having side effects?\nSome side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it.\nWhat symptoms are bothering you?\nSometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation.\nHave you taken an SSRI before?\nIf you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again.\nAre you pregnant?\nIf you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the\nsafer SSRIs\nto use during pregnancy. \nKeep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you.\nThere are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts,\ncopay savings cards\n, and\npatient assistance programs\n. You can find SSRIs\nas low as $5\nwith a free GoodRx discount.\nFor many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of\n$250\n.\nThe bottom line\nThere are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one.\nAlex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy.\nSarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.\nAmy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California.\nGoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our\neditorial guidelines\n.","attrs_markdown":"[Skip to main content](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#skip-to-content)\n\nAre you a healthcare professional? [Join GoodRx for HCPs](https:\/\/www.goodrx.com\/hcp\/join?redirectTo=%2Fclasses%2Fssris%2Fssri-list)\n\n- [Prescription savingsSavings](https:\/\/www.goodrx.com\/)\n  Prescription savings\n  \n  Stop paying too much for your prescriptions. 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[Home](https:\/\/www.goodrx.com\/health)\n2. [Drug Classes](https:\/\/www.goodrx.com\/classes)\n3. [SSRIs](https:\/\/www.goodrx.com\/classes\/ssris)\n\nSSRIs\n\n# Zoloft, Prozac, and More: A List of 7 SSRIs and How They All Compare\n\n[![Alex Evans, PharmD, MBA](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/1hUSCabcoMdzEp7FxKLLyN\/f08190e47cb3ea4bbd8c8716413a4729\/alex_evans_goodrx.jpg?w=96&q=85&fm=webp)](https:\/\/www.goodrx.com\/about\/bio\/alex-evans)[![Sarah Gupta, MD](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/1ljb93nV7dT0ERWToKD94t\/d26c54bf4ca8373dabe7240a31e39923\/Sarah-Gupta.webp?w=96&q=85&fm=webp)](https:\/\/www.goodrx.com\/about\/bio\/sarah-gupta)\n\nWritten by [Alex Evans, PharmD, MBA](https:\/\/www.goodrx.com\/about\/bio\/alex-evans) \\| Reviewed by [Sarah Gupta, MD](https:\/\/www.goodrx.com\/about\/bio\/sarah-gupta), [Amy B. Gragnolati, PharmD, BCPS](https:\/\/www.goodrx.com\/about\/bio\/amy-gragnolati)\n\nPublished on March 10, 2023\n\n![star](https:\/\/www.grxstatic.com\/images\/star-with-circle.svg)![A woman discusses treatment options with a counselor.](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3MQ0Ga0AMhypEoSj7tZDTv\/13c98a93b76b34b256877df376d0d2c2\/counselor_discussion_1150732827.jpg?w=3840&q=99&fm=webp)\n\nFatCamera\/E+ + via Getty Images\n\n[Fluoxetine](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#fluoxetine)[Sertraline](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#sertraline)[Paroxetine](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#paroxetine)[Citalopram](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#citalopram)[Escitalopram](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#escitalopram)[Fluvoxamine](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#fluvoxamine)[Vilazodone](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#vilazodone)[Considerations](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#considerations)[How to save](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#how-to-save)[Bottom line](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#bottom-line)[References](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#references)\n\n## Key takeaways:\n- Selective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil).\n- Your medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you.\n- There are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription [more affordable](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#how-to-save).\n\n#### Save on related medications\nPromotional Disclosure\n\n[prozac](https:\/\/www.goodrx.com\/prozac \"prozac cost and coupons\")[fluoxetine](https:\/\/www.goodrx.com\/fluoxetine \"fluoxetine cost and coupons\")[escitalopram](https:\/\/www.goodrx.com\/escitalopram \"escitalopram cost and coupons\")[lexapro](https:\/\/www.goodrx.com\/lexapro \"lexapro cost and coupons\")\n\n[Selective serotonin reuptake inhibitors (SSRIs)](https:\/\/www.goodrx.com\/classes\/ssris) are a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re [thought to work](https:\/\/www.goodrx.com\/classes\/ssris\/how-ssris-work) by increasing availability of a chemical in the brain called [serotonin](https:\/\/www.goodrx.com\/health-topic\/hormones\/serotonin). Common examples of SSRIs include [fluoxetine](https:\/\/www.goodrx.com\/prozac\/what-is) (Prozac), [sertraline](https:\/\/www.goodrx.com\/zoloft\/what-is) (Zoloft), and [paroxetine](https:\/\/www.goodrx.com\/paroxetine\/what-is) (Paxil).\n\nBut with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs.\n\n## 1\\. Fluoxetine\nFluoxetine (Prozac) was [approved in 1987](https:\/\/meridian.allenpress.com\/mhc\/article\/4\/1\/11\/37061\/Antidepressant-medications-The-FDA-approval), making it the oldest SSRI available in the U.S. It’s [approved to treat:](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55)\n\n- [Major depressive disorder](https:\/\/www.goodrx.com\/conditions\/depression) (MDD)\n- [Obsessive-compulsive disorder](https:\/\/www.goodrx.com\/conditions\/obsessive-compulsive-disorder) (OCD)\n- [Bulimia](https:\/\/www.goodrx.com\/conditions\/eating-disorders\/bulimia)\n- [Panic disorder](https:\/\/www.goodrx.com\/conditions\/panic-disorder)\n- Depression in [bipolar 1 disorder](https:\/\/www.goodrx.com\/conditions\/bipolar-disorder\/bipolar-1-vs-2-differences)\n- [Premenstrual dysphoric disorder](https:\/\/www.goodrx.com\/conditions\/pmdd) (PMDD)\n\nFluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The [DR capsules](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5), which can be taken once weekly, are only approved to treat MDD.\n\n### Key differences\n**Side effects:** SSRIs can make some people feel [drowsy](https:\/\/www.goodrx.com\/drugs\/side-effects\/prescription-make-you-tired). But fluoxetine can be more “[activating](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\/),” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take [your dose](https:\/\/www.goodrx.com\/prozac\/dosage) in the morning. Fluoxetine also [sticks around longer](https:\/\/www.goodrx.com\/prozac\/missed-dose-of-prozac) in your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called [discontinuation syndrome](https:\/\/www.goodrx.com\/classes\/atypical-antidepressants\/antidepressant-discontinuation-syndrome)).\n\n**Interactions:** Fluoxetine can [interfere with](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181142\/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20\$Table%202\$.) how your body breaks down other medications, resulting in several [significant interactions](https:\/\/www.goodrx.com\/fluoxetine\/interactions). And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose.\n\n**Use in pregnancy:** SSRIs are generally considered the [safer antidepressant options](https:\/\/www.goodrx.com\/conditions\/depression\/safest-antidepressant-in-pregnancy) to take during pregnancy. But fluoxetine [has been linked](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html) to an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant.\n\n## 2\\. Sertraline\nSertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for:\n\n- Panic disorder\n- [Post-traumatic stress disorder](https:\/\/www.goodrx.com\/conditions\/ptsd) (PTSD)\n- [Social anxiety disorder](https:\/\/www.goodrx.com\/conditions\/social-anxiety-disorder)\n\n![Goodrx logo](https:\/\/www.grxstatic.com\/images\/goodrx-logo.svg)\n\n### Read more like this\n#### Explore these related articles, suggested for readers like you.\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/50AN3uQ5xDRCgRBmafPlz9\/cef5b2ddfb33b724dcf1127f8e29dcfe\/cropped_portrait_sad_middle_aged_man-672278426.jpg?w=256&q=100&fm=webp)\n\n[Can Antidepressants and Anti-Anxiety Drugs Cause Erectile Dysfunction?](https:\/\/www.goodrx.com\/drugs\/side-effects\/antidepressants-anti-anxiety-drugs-erectile-dysfunction-side-effect)\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3n87MtK6CgCp796X2IK914\/9e5a9a0fc376d293174f3b3953915f34\/closeup_man_drinking_wine_label_1128467471.jpg?w=256&q=100&fm=webp)\n\n[Can You Mix Zoloft and Alcohol? The Risks of Drinking with SSRI Antidepressants](https:\/\/www.goodrx.com\/classes\/ssris\/can-i-drink-alcohol-while-taking-zoloft)\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/4G3YczsIjg6VY6KLo6ed8I\/66f71dd48647878d77ae8085b4a91b35\/woman_reading_Rx_bottle_1289796290.jpg?w=256&q=100&fm=webp)\n\n[10 Things to Know Before Starting an SNRI Like Cymbalta](https:\/\/www.goodrx.com\/classes\/snris\/snri-side-effects)\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/1dZU4vt4qhwSasrHbPms8s\/31360330085c813c1e5b28e7d5ae9bf3\/tired_in_bed_512896520.webp?w=256&q=100&fm=webp)\n\n[10 Paroxetine (Paxil) Side Effects You Should Know About](https:\/\/www.goodrx.com\/paroxetine\/paroxetine-side-effects)\n\nView more\n\nSertraline is [available as](https:\/\/www.goodrx.com\/zoloft\/zoloft-dosage) tablets, capsules, and an oral solution.\n\n### Key differences\n**Side effects**: Sertraline may be more likely to [cause diarrhea](https:\/\/www.goodrx.com\/sertraline\/common-side-effects) than other SSRIs, though this usually goes away within a few weeks.\n\n**Use during pregnancy**: Of the SSRs, sertraline may be [one of the safest](https:\/\/www.goodrx.com\/conditions\/pregnancy\/antidepressants-like-zoloft-prozac) to take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation.\n\n## 3\\. Paroxetine\nParoxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension.\n\nPexeva is another [form of paroxetine](https:\/\/www.goodrx.com\/classes\/ssris\/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better) that’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet. [Brisdelle](https:\/\/www.goodrx.com\/brisdelle\/what-is) is a lower-dose paroxetine capsule that’s specifically approved to [treat hot flashes](https:\/\/www.goodrx.com\/conditions\/menopause\/antidepressants-for-menopause) in menopausal women.\n\n### Key differences\n**Side effects**: Paroxetine tends to cause [more side effects](https:\/\/www.goodrx.com\/paroxetine\/paroxetine-side-effects) than other SSRIs. These can include [weight gain](https:\/\/www.goodrx.com\/paroxetine\/paroxetine-weight-gain), [sexual side effects](https:\/\/www.goodrx.com\/conditions\/erectile-dysfunction\/antidepressants-without-sexual-side-effects), and drowsiness. Paxil is also [more likely](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526022\/) to cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you [stop taking it](https:\/\/www.goodrx.com\/conditions\/depression\/how-to-get-off-antidepressants) too quickly. But side effects like weight gain and decreased libido [may be less likely](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4175016\/) if you’re taking Brisdelle.\n\n**Interactions:** Paroxetine has several of the [same interactions](http:\/\/www.eurekaselect.com\/article\/9390) as fluoxetine. And unlike other SSRIs, paroxetine can [build up in your body](https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468024916300845) if you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower [dosage](https:\/\/www.goodrx.com\/paxil\/dosage).\n\n**Use during pregnancy**: Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But [several birth defects](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html) have been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment.\n\n## 4\\. Citalopram\n[Citalopram](https:\/\/www.goodrx.com\/citalopram\/what-is) (Celexa) is only approved to treat depression. But it’s used off-label to treat [several other](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482222\/) mental health conditions. It’s available as a tablet, capsule, and oral solution.\n\n### Key differences\n**Side effects:** Compared to other SSRIs, citalopram is associated with a [higher risk](https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.) of abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking [certain medications](https:\/\/www.goodrx.com\/citalopram\/interactions) that interact with citalopram.\n\n**Interactions:** Compared to other SSRIs, citalopram may be [less likely](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38) to interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above, [interactions are still possible](https:\/\/www.goodrx.com\/citalopram\/interactions).\n\n## 5\\. Escitalopram\n[Escitalopram](https:\/\/www.goodrx.com\/lexapro\/what-is) (Lexapro) is approved to treat MDD and [generalized anxiety disorder](https:\/\/www.goodrx.com\/conditions\/generalized-anxiety-disorder) (GAD). It’s available as a tablet and oral solution.\n\n[Escitalopram and citalopram](https:\/\/www.goodrx.com\/classes\/ssris\/celexa-vs-lexapro) are similar, but they’re [not the same](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38). Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also [more specific](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC315490\/) to serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram.\n\n### Key differences\n**Side effects**: Escitalopram may also have a risk of abnormal heart rhythms, especially if you [take doses](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15) that are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram.\n\n**Interactions:** Similar to citalopram, escitalopram may have fewer interactions than other SSRIs.\n\n## 6\\. Fluvoxamine\n[Fluvoxamine](https:\/\/www.goodrx.com\/fluvoxamine\/what-is) (Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules.\n\n### Key differences\n**Side effects**: All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these [side effects](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/) more often. And in some clinical studies, more people [stopped taking fluvoxamine](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/#:~:text=Fluvoxamine%20is%20associated%20with%20the,and%20sertraline%20\$40%25\$.) due to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly.\n\n**Interactions:** Fluvoxamine also has an [increased risk](https:\/\/www.uspharmacist.com\/article\/overview-of-drugdrug-interactions-with-ssris) of interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can [interfere with](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1884944\/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.) how caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it.\n\n## 7\\. Vilazodone\n[Vilazodone](https:\/\/www.goodrx.com\/viibryd\/what-is) (Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD.\n\nVilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants. [Researchers do think](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9206504\/) this difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure.\n\n### Key differences\n**How you take it:** Taking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone *should be* taken with food. If you take it on an empty stomach, it may not work as well.\n\n## How do I find out which SSRI is right for me?\nThe best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider.\n\nA few considerations may include:\n\n- **Can you swallow pills?** If you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions.\n- **Do you take other medications?** Certain SSRIs, including paroxetine and fluoxetine, have a higher [risk of interactions](https:\/\/www.goodrx.com\/classes\/ssris\/interactions). If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred.\n- **Do you have any other health conditions?** Your medical history could also influence your choice of SSRI. For example, citalopram [may be avoided](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8) if you’ve recently had a heart attack.\n- **Are you having side effects?** Some side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it.\n- **What symptoms are bothering you?** Sometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation.\n- **Have you taken an SSRI before?** If you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again.\n- **Are you pregnant?** If you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the [safer SSRIs](https:\/\/www.uptodate.com\/contents\/depression-treatment-options-for-adults-beyond-the-basics#H3044082849) to use during pregnancy.\n\nKeep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you.\n\n## How to save on SSRIs\nThere are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts, [copay savings cards](https:\/\/www.goodrx.com\/drugs\/savings\/what-are-manufacturer-copay-cards), and [patient assistance programs](https:\/\/www.goodrx.com\/healthcare-access\/patient-advocacy\/what-are-patient-assistance-programs). You can find SSRIs [as low as \\$5](https:\/\/www.goodrx.com\/classes\/ssris) with a free GoodRx discount.\n\nFor many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of [\\$250](https:\/\/www.goodrx.com\/zoloft?label_override=zoloft).\n\n## The bottom line\nThere are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one.\n\n![why trust our exports reliability shield](https:\/\/www.grxstatic.com\/images\/reliability.svg)\n\n## Why trust our experts?\n\n![Alex Evans, PharmD, MBA](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1hUSCabcoMdzEp7FxKLLyN\/f08190e47cb3ea4bbd8c8716413a4729\/alex_evans_goodrx.jpg)\n\n![Alex Evans, PharmD, MBA](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1hUSCabcoMdzEp7FxKLLyN\/f08190e47cb3ea4bbd8c8716413a4729\/alex_evans_goodrx.jpg)\n\nWritten by:\n\n[Alex Evans, PharmD, MBA](https:\/\/www.goodrx.com\/about\/bio\/alex-evans)\n\nAlex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy.\n\n![Sarah Gupta, MD](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1ljb93nV7dT0ERWToKD94t\/d26c54bf4ca8373dabe7240a31e39923\/Sarah-Gupta.webp)\n\n![Sarah Gupta, MD](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1ljb93nV7dT0ERWToKD94t\/d26c54bf4ca8373dabe7240a31e39923\/Sarah-Gupta.webp)\n\nReviewed by:\n\n[Sarah Gupta, MD](https:\/\/www.goodrx.com\/about\/bio\/sarah-gupta)\n\nSarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.\n\n![Amy B. Gragnolati, PharmD, BCPS](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/5q7aMo8XCWrAzU6I3J4FbK\/01ec68b4535a0858aefcae788642d08d\/Amy_Gragnolati.webp)\n\n![Amy B. Gragnolati, PharmD, BCPS](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/5q7aMo8XCWrAzU6I3J4FbK\/01ec68b4535a0858aefcae788642d08d\/Amy_Gragnolati.webp)\n\nReviewed by:\n\n[Amy B. Gragnolati, PharmD, BCPS](https:\/\/www.goodrx.com\/about\/bio\/amy-gragnolati)\n\nAmy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California.\n\n![Green trust check mark](https:\/\/www.grxstatic.com\/images\/green-check-mark.svg)[Our editorial standards](https:\/\/www.goodrx.com\/about\/editorial-guidelines)\n\n![Green trust check mark](https:\/\/www.grxstatic.com\/images\/green-check-mark.svg)[Meet our experts](https:\/\/www.goodrx.com\/about\/health#meet-our-healthcare-experts)\n\n## References\nBrown, C. H. (2008). [Overview of drug-drug interactions with SSRIs](https:\/\/www.uspharmacist.com\/article\/overview-of-drugdrug-interactions-with-ssris). U.S. Pharmacist.\n\nCenters for Disease Control and Prevention. (2020). [Key findings—a closer look at the link between specific SSRIs and birth defects](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html).\n\n### View All References (19)\nChauhan, M., et al. (2022). [Vilazodone for major Depression in Adults: Pharmacological profile and an updated review for clinical practice](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9206504\/). *Neuropsychiatric Disease and Treatment*.\n\nCulm-Merdek, K. E., et al. (2005). [Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1884944\/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.). *British Journal of Clinical Pharmacology*.\n\nCulpepper, L. (2002). [Escitalopram: A new SSRI for the treatment of depression in primary care](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC315490\/). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nDailyMed. (2021). [Escitalopram](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15).\n\nDailyMed. (2021). [Fluoxetine hydrochloride](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5).\n\nDailyMed. (2022). [Citalopram](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8).\n\nDailyMed. (2023). [Fluoxetine](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55).\n\nEdinoff, A. N., et al. (2021). [Selective serotonin reuptake inhibitors and adverse effects: A narrative review](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38). *Neurology International*.\n\nFerguson, J. M. (2001). [SSRI Antidepressant Medications: Adverse Effects and Tolerability](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nHanrahan, C., et al. (2014). [Antidepressant medications: The FDA-approval process and the need for updates](https:\/\/meridian.allenpress.com\/mhc\/article\/4\/1\/11\/37061\/Antidepressant-medications-The-FDA-approval). *Mental Health Clinician.*\n\nHemeryck, A., et al. (2002). [Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update](https:\/\/www.eurekaselect.com\/article\/9390). *Current Drug Metabolism*.\n\nMarken, P. A., et al. (2000). [Selecting a selective serotonin reuptake inhibitor: Clinically important distinguishing features](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181142\/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20\$Table%202\$.). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nPortman, D. J., et al. (2014). [Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4175016\/). *Menopause*.\n\nRush, A. J. (2023). [Patient education: Depression treatment options for adults (beyond the basics)](https:\/\/www.uptodate.com\/contents\/depression-treatment-options-for-adults-beyond-the-basics#H3044082849). UpToDate.\n\nShirazian, S., et al. (2017). [Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management](https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468024916300845). *Kidney International Reports.*\n\nShoar, N. S., et al. (2021). [Citalopram](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482222\/). StatPearls.\n\nShrestha, P., et al. (2022). [Paroxetine](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526022\/). StatPearls.\n\nSohel, A. J., et al. (2022). [Fluoxetine](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\/). StatPearls.\n\nU.S. Food and Drug Administration. (2017). [FDA drug safety communication: Revised recommendations for celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses](https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.).\n\nGoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https:\/\/www.goodrx.com\/about\/editorial-guidelines).\n\nBrown, C. H. (2008). [Overview of drug-drug interactions with SSRIs](https:\/\/www.uspharmacist.com\/article\/overview-of-drugdrug-interactions-with-ssris). U.S. Pharmacist.\n\nCenters for Disease Control and Prevention. (2020). [Key findings—a closer look at the link between specific SSRIs and birth defects](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html).\n\nChauhan, M., et al. (2022). [Vilazodone for major Depression in Adults: Pharmacological profile and an updated review for clinical practice](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9206504\/). *Neuropsychiatric Disease and Treatment*.\n\nCulm-Merdek, K. E., et al. (2005). [Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1884944\/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.). *British Journal of Clinical Pharmacology*.\n\nCulpepper, L. (2002). [Escitalopram: A new SSRI for the treatment of depression in primary care](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC315490\/). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nDailyMed. (2021). [Escitalopram](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15).\n\nDailyMed. (2021). [Fluoxetine hydrochloride](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5).\n\nDailyMed. (2022). [Citalopram](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8).\n\nDailyMed. (2023). [Fluoxetine](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55).\n\nEdinoff, A. N., et al. (2021). [Selective serotonin reuptake inhibitors and adverse effects: A narrative review](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38). *Neurology International*.\n\nFerguson, J. M. (2001). [SSRI Antidepressant Medications: Adverse Effects and Tolerability](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nHanrahan, C., et al. (2014). [Antidepressant medications: The FDA-approval process and the need for updates](https:\/\/meridian.allenpress.com\/mhc\/article\/4\/1\/11\/37061\/Antidepressant-medications-The-FDA-approval). *Mental Health Clinician.*\n\nHemeryck, A., et al. (2002). [Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update](https:\/\/www.eurekaselect.com\/article\/9390). *Current Drug Metabolism*.\n\nMarken, P. A., et al. (2000). [Selecting a selective serotonin reuptake inhibitor: Clinically important distinguishing features](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181142\/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20\$Table%202\$.). *Primary Care Companion to the Journal of Clinical Psychiatry*.\n\nPortman, D. J., et al. (2014). [Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4175016\/). *Menopause*.\n\nRush, A. J. (2023). [Patient education: Depression treatment options for adults (beyond the basics)](https:\/\/www.uptodate.com\/contents\/depression-treatment-options-for-adults-beyond-the-basics#H3044082849). UpToDate.\n\nShirazian, S., et al. (2017). [Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management](https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468024916300845). *Kidney International Reports.*\n\nShoar, N. S., et al. (2021). [Citalopram](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482222\/). StatPearls.\n\nShrestha, P., et al. (2022). [Paroxetine](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526022\/). StatPearls.\n\nSohel, A. J., et al. (2022). [Fluoxetine](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\/). StatPearls.\n\nU.S. Food and Drug Administration. (2017). [FDA drug safety communication: Revised recommendations for celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses](https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.).\n\n![Newsletter Subscription](https:\/\/www.grxstatic.com\/images\/notification-email-female.svg)\n\n#### Subscribe and save\nGet prescription saving tips and more from GoodRx Health. Enter your email to sign up\n\n### Latest articles\n[![Health: SSRIs: closeup man drinking wine label 1128467471](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3n87MtK6CgCp796X2IK914\/9e5a9a0fc376d293174f3b3953915f34\/closeup_man_drinking_wine_label_1128467471.jpg?w=640&q=85&fm=webp) SSRIs Can You Mix Zoloft and Alcohol? The Risks of Drinking with SSRI Antidepressants Written by Christina Aungst, PharmDUpdated on Sep 12, 2025 by Christina Aungst, PharmD • Sep 12, 2025](https:\/\/www.goodrx.com\/classes\/ssris\/can-i-drink-alcohol-while-taking-zoloft)\n\n[![SSRIs: closeup hand with pills 1463754712](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/10bTOkjqS16EuSEnhAfYMJ\/e0b3882b49659b3c111001e43490eaa0\/closeup_hand_with_pills_1463754712.jpg?w=640&q=85&fm=webp) SSRIs Which SSRI Antidepressants Have the Least Side Effects? How to Find the Right One for You Written by Tegan Smedley, PharmD, APhUpdated on Aug 22, 2025 by Tegan Smedley, PharmD, APh • Aug 22, 2025](https:\/\/www.goodrx.com\/classes\/ssris\/least-side-effects)\n\n[![Depression: Zoloft or Lexapro: sad woman beanie coffee shop 1094194856](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/5HEMWIGLK5Ci07Z4BJf9MX\/48ff02a4839b0ed6fbfae97fbf37605f\/sad_woman_beanie_coffee_shop-1094194856.jpg?w=640&q=85&fm=webp) SSRIs Zoloft vs. Lexapro for Depression: 5 Key Differences, from Dosages to Side Effects Written by Jennifer Gershman, PharmD, CPh, PACSUpdated on Feb 6, 2025 by Jennifer Gershman, PharmD, CPh, PACS • Feb 6, 2025](https:\/\/www.goodrx.com\/classes\/ssris\/zoloft-vs-lexapro)\n\n[![SSRIS: woman researching medication on smart phone 1466976251](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/HYv1tdCoZLmxwXTMKzZnR\/df600f18bdcd58c042269805aa283934\/woman_researching_medication_on_smart_phone_1466976251.jpg?w=640&q=85&fm=webp) SSRIs Celexa vs. Zoloft: The Top 5 Differences Between These SSRI Antidepressants Written by Jenna Clayton, PharmDPublished on Jan 6, 2025 by Jenna Clayton, PharmD • Jan 6, 2025](https:\/\/www.goodrx.com\/classes\/ssris\/celexa-vs-zoloft)\n\n[![SSRIs: drug interaction ssri](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/609w6D7YfoJ1HzC1L24bGJ\/7cec0faddfa077ace1179c3c14776983\/drug_interaction_ssri.png?w=640&q=85&fm=webp) SSRIs 9 SSRI Interactions: Blood Thinners, Ibuprofen, and More Written by Brian Leonard, PharmD, BCACP, BCGPPublished on Feb 1, 2024 by Brian Leonard, PharmD, BCACP, BCGP • Feb 1, 2024](https:\/\/www.goodrx.com\/classes\/ssris\/interactions)\n\n[![Health: SSRIs: woman consulting doctor on medication 1310664428](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3dDkoK6u7DDVCNLvpyYFG7\/ab2bcffb74f89bb207785f0aeead2e29\/woman_consulting_doctor_on_medication-1310664428.jpg?w=640&q=85&fm=webp) SSRIs How Do SSRIs Work? The Mechanism Behind Zoloft, Lexapro, and More Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMPUpdated on Oct 10, 2023 by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP • Oct 10, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/how-ssris-work)\n\n[![Health: Health Insurance: GettyImages 674796452](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/6EumQkAk4hmSL7NzkJu7ph\/7a4b39e3f7ad33af44696312ecc6e8a8\/GettyImages-674796452.jpeg?w=640&q=85&fm=webp) SSRIs Serotonin Syndrome: What You Need to Know If You Take SSRIs Written by Sameer Hassamal, MDUpdated on Aug 25, 2023 by Sameer Hassamal, MD • Aug 25, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/what-is-serotonin-syndrome)\n\n[![Health: SSRIS: side effects ssri](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/2MC7HBNoxw1CGlYB6nAuia\/6f4ff71f8d193d1fb04b0dfbbcf026f0\/side_effects_ssri.png?w=640&q=85&fm=webp) SSRIs 11 Possible Side Effects of SSRIs Written by Stacia Woodcock, PharmDUpdated on Jul 5, 2023 by Stacia Woodcock, PharmD • Jul 5, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/ssris-what-you-should-know-side-effects)\n\n[![atypical antidepressants: withdrawal: sad person looking out window 1201429767](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/249BzvNBMV3fYpG8lLwwZD\/0388a24d21dcc951abe35b50ad831c9e\/sad_person_looking_out_window-1201429767.jpg?w=640&q=85&fm=webp) SSRIs What Is Antidepressant Discontinuation Syndrome? Withdrawal from Antidepressants Explained Written by Kevin Le, PharmD, BCPS, BCPPSUpdated on May 10, 2023 by Kevin Le, PharmD, BCPS, BCPPS • May 10, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/antidepressant-discontinuation-syndrome)\n\n[![Health: Class: GettyImages 1282217910](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3UqroJwceoQOqiLx5pUgcN\/a9762afdbfc6a9f3ff282abf83d15e61\/GettyImages-1282217910.jpg?w=640&q=85&fm=webp) SSRIs Zoloft, Wellbutrin, and More: Are Antidepressants Safe for Breastfeeding? Written by Nidhi Gandhi-Patel, PharmD, BSUpdated on Apr 14, 2023 by Nidhi Gandhi-Patel, PharmD, BS • Apr 14, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/are-zoloft-prozac-ssris-safe-while-breastfeeding)\n\n[![SSRIs: cropped doctor patient discussing two pill bottles 1397290480](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/4Ml2PlcBUrjkbA8DnQVo1c\/9a043aabfbfc47bc7226b34e41040955\/cropped_doctor_patient_discussing_two_pill_bottles_1397290480.jpg?w=640&q=85&fm=webp) SSRIs Paxil vs. Pexeva for Depression: Which Is Best? Written by Christina Aungst, PharmDUpdated on Jan 18, 2023 by Christina Aungst, PharmD • Jan 18, 2023](https:\/\/www.goodrx.com\/classes\/ssris\/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better)\n\n[![SSRIS: Celexa vs Lexapro: sad woman looking out window-1319976569](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/2AslvnphS0swYu3mHBKPiu\/cb9208c652eef4d69491d9d0e1712c09\/sad_woman_looking_out_window-1319976569.jpg?w=640&q=85&fm=webp) SSRIs Celexa vs. Lexapro for Depression Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMPPublished on Jun 10, 2022 by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP • Jun 10, 2022](https:\/\/www.goodrx.com\/classes\/ssris\/celexa-vs-lexapro)\n\nView more\n\n##### Subscribe and save\nGet prescription saving tips and more from GoodRx Health. 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If you are having difficulty accessing this website, please call or email us at [1-855-268-2822](<tel: +18552682822>) or [ada@goodrx.com](<mailto: ada@goodrx.com>) so that we can provide you with the services you require through alternative means.\n\nCopyright ©2011–2026 GoodRx, Inc.\n\n[![LegitScript Logo, opens in a new window](https:\/\/static.legitscript.com\/seals\/338276.png?width=256&quality=85&auto=webp)](https:\/\/www.legitscript.com\/websites\/?checker_keywords=goodrx.com)[![National Association of Boards of Pharmacy Logo, opens in a new window](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/7BflV93nkrARWlhjT0OpL3\/41f2d7661bc44e0b14eac2269c92bd0b\/6e174cd343d6b3b47288ee3ea13a61ab.png?format=png&auto=webp&width=182?w=384&q=85&fm=webp)](https:\/\/safe.pharmacy\/buy-safely\/)[![Better Business Bureau Logo, opens in a new window](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/xXC4tWf17QuV268j1yOiR\/4d2427d015a8d78f83af07b8c9a9ba3f\/2dea00a13eeceedf6c458d97e3bc9163.png?format=png&auto=webp&width=121?w=256&q=85&fm=webp)](https:\/\/www.bbb.org\/us\/ca\/santa-monica\/profile\/online-pharmacy\/goodrx-1216-351397#bbbseal)\n\n![](https:\/\/sync.graph.bluecava.com\/p.png?p=ddb38364-ed0e-11ec-8ee0-4201ac10000b&segment=732bbede0eedec11834342010a78800a&uid=undefined&event=page_view&rn=1775047852853)\n\n![](https:\/\/sb.scorecardresearch.com\/p?c1=2&c2=33256513&cs_ucfr=1)\n\n![](https:\/\/match.prod.bidr.io\/cookie-sync\/goodrx?buyer_user_id=undefined&env=prod)\n\n![](https:\/\/cnv.event.prod.bidr.io\/log\/cnv?tag_id=6&buzz_key=goodrx&value=1&segment_key=&account_id=4&ord=705663452)","attrs_readable_markdown":"## Key takeaways:\n- Selective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil).\n- Your medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you.\n- There are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription [more affordable](https:\/\/www.goodrx.com\/classes\/ssris\/ssri-list#how-to-save).\n\n[Selective serotonin reuptake inhibitors (SSRIs)](https:\/\/www.goodrx.com\/classes\/ssris) are a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re [thought to work](https:\/\/www.goodrx.com\/classes\/ssris\/how-ssris-work) by increasing availability of a chemical in the brain called [serotonin](https:\/\/www.goodrx.com\/health-topic\/hormones\/serotonin). Common examples of SSRIs include [fluoxetine](https:\/\/www.goodrx.com\/prozac\/what-is) (Prozac), [sertraline](https:\/\/www.goodrx.com\/zoloft\/what-is) (Zoloft), and [paroxetine](https:\/\/www.goodrx.com\/paroxetine\/what-is) (Paxil).\n\nBut with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs.\n\nFluoxetine (Prozac) was [approved in 1987](https:\/\/meridian.allenpress.com\/mhc\/article\/4\/1\/11\/37061\/Antidepressant-medications-The-FDA-approval), making it the oldest SSRI available in the U.S. It’s [approved to treat:](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55)\n\nFluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The [DR capsules](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5), which can be taken once weekly, are only approved to treat MDD.\n\n**Side effects:** SSRIs can make some people feel [drowsy](https:\/\/www.goodrx.com\/drugs\/side-effects\/prescription-make-you-tired). But fluoxetine can be more “[activating](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\/),” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take [your dose](https:\/\/www.goodrx.com\/prozac\/dosage) in the morning. Fluoxetine also [sticks around longer](https:\/\/www.goodrx.com\/prozac\/missed-dose-of-prozac) in your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called [discontinuation syndrome](https:\/\/www.goodrx.com\/classes\/atypical-antidepressants\/antidepressant-discontinuation-syndrome)).\n\n**Interactions:** Fluoxetine can [interfere with](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181142\/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20\$Table%202\$.) how your body breaks down other medications, resulting in several [significant interactions](https:\/\/www.goodrx.com\/fluoxetine\/interactions). And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose.\n\n**Use in pregnancy:** SSRIs are generally considered the [safer antidepressant options](https:\/\/www.goodrx.com\/conditions\/depression\/safest-antidepressant-in-pregnancy) to take during pregnancy. But fluoxetine [has been linked](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html) to an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant.\n\nSertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for:\n\n![Goodrx logo](https:\/\/www.grxstatic.com\/images\/goodrx-logo.svg)\n\nRead more like thisExplore these related articles, suggested for readers like you.\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/50AN3uQ5xDRCgRBmafPlz9\/cef5b2ddfb33b724dcf1127f8e29dcfe\/cropped_portrait_sad_middle_aged_man-672278426.jpg?w=256&q=100&fm=webp)\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/3n87MtK6CgCp796X2IK914\/9e5a9a0fc376d293174f3b3953915f34\/closeup_man_drinking_wine_label_1128467471.jpg?w=256&q=100&fm=webp)\n\n![](https:\/\/www.grxstatic.com\/4f3rgqwzdznj\/4G3YczsIjg6VY6KLo6ed8I\/66f71dd48647878d77ae8085b4a91b35\/woman_reading_Rx_bottle_1289796290.jpg?w=256&q=100&fm=webp)\n\nView more\n\nSertraline is [available as](https:\/\/www.goodrx.com\/zoloft\/zoloft-dosage) tablets, capsules, and an oral solution.\n\n**Side effects**: Sertraline may be more likely to [cause diarrhea](https:\/\/www.goodrx.com\/sertraline\/common-side-effects) than other SSRIs, though this usually goes away within a few weeks.\n\n**Use during pregnancy**: Of the SSRs, sertraline may be [one of the safest](https:\/\/www.goodrx.com\/conditions\/pregnancy\/antidepressants-like-zoloft-prozac) to take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation.\n\nParoxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension.\n\nPexeva is another [form of paroxetine](https:\/\/www.goodrx.com\/classes\/ssris\/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better) that’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet. [Brisdelle](https:\/\/www.goodrx.com\/brisdelle\/what-is) is a lower-dose paroxetine capsule that’s specifically approved to [treat hot flashes](https:\/\/www.goodrx.com\/conditions\/menopause\/antidepressants-for-menopause) in menopausal women.\n\n**Side effects**: Paroxetine tends to cause [more side effects](https:\/\/www.goodrx.com\/paroxetine\/paroxetine-side-effects) than other SSRIs. These can include [weight gain](https:\/\/www.goodrx.com\/paroxetine\/paroxetine-weight-gain), [sexual side effects](https:\/\/www.goodrx.com\/conditions\/erectile-dysfunction\/antidepressants-without-sexual-side-effects), and drowsiness. Paxil is also [more likely](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK526022\/) to cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you [stop taking it](https:\/\/www.goodrx.com\/conditions\/depression\/how-to-get-off-antidepressants) too quickly. But side effects like weight gain and decreased libido [may be less likely](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4175016\/) if you’re taking Brisdelle.\n\n**Interactions:** Paroxetine has several of the [same interactions](http:\/\/www.eurekaselect.com\/article\/9390) as fluoxetine. And unlike other SSRIs, paroxetine can [build up in your body](https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2468024916300845) if you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower [dosage](https:\/\/www.goodrx.com\/paxil\/dosage).\n\n**Use during pregnancy**: Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But [several birth defects](https:\/\/www.cdc.gov\/pregnancy\/meds\/treatingfortwo\/features\/ssrisandbirthdefects.html) have been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment.\n\n[Citalopram](https:\/\/www.goodrx.com\/citalopram\/what-is) (Celexa) is only approved to treat depression. But it’s used off-label to treat [several other](https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482222\/) mental health conditions. It’s available as a tablet, capsule, and oral solution.\n\n**Side effects:** Compared to other SSRIs, citalopram is associated with a [higher risk](https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.) of abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking [certain medications](https:\/\/www.goodrx.com\/citalopram\/interactions) that interact with citalopram.\n\n**Interactions:** Compared to other SSRIs, citalopram may be [less likely](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38) to interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above, [interactions are still possible](https:\/\/www.goodrx.com\/citalopram\/interactions).\n\n[Escitalopram](https:\/\/www.goodrx.com\/lexapro\/what-is) (Lexapro) is approved to treat MDD and [generalized anxiety disorder](https:\/\/www.goodrx.com\/conditions\/generalized-anxiety-disorder) (GAD). It’s available as a tablet and oral solution.\n\n[Escitalopram and citalopram](https:\/\/www.goodrx.com\/classes\/ssris\/celexa-vs-lexapro) are similar, but they’re [not the same](https:\/\/www.mdpi.com\/2035-8377\/13\/3\/38). Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also [more specific](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC315490\/) to serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram.\n\n**Side effects**: Escitalopram may also have a risk of abnormal heart rhythms, especially if you [take doses](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15) that are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram.\n\n**Interactions:** Similar to citalopram, escitalopram may have fewer interactions than other SSRIs.\n\n[Fluvoxamine](https:\/\/www.goodrx.com\/fluvoxamine\/what-is) (Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules.\n\n**Side effects**: All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these [side effects](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/) more often. And in some clinical studies, more people [stopped taking fluvoxamine](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/#:~:text=Fluvoxamine%20is%20associated%20with%20the,and%20sertraline%20\$40%25\$.) due to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly.\n\n**Interactions:** Fluvoxamine also has an [increased risk](https:\/\/www.uspharmacist.com\/article\/overview-of-drugdrug-interactions-with-ssris) of interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can [interfere with](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1884944\/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.) how caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it.\n\n[Vilazodone](https:\/\/www.goodrx.com\/viibryd\/what-is) (Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD.\n\nVilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants. [Researchers do think](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9206504\/) this difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure.\n\n**How you take it:** Taking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone *should be* taken with food. If you take it on an empty stomach, it may not work as well.\n\nThe best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider.\n\nA few considerations may include:\n\n- **Can you swallow pills?** If you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions.\n- **Do you take other medications?** Certain SSRIs, including paroxetine and fluoxetine, have a higher [risk of interactions](https:\/\/www.goodrx.com\/classes\/ssris\/interactions). If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred.\n- **Do you have any other health conditions?** Your medical history could also influence your choice of SSRI. For example, citalopram [may be avoided](https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8) if you’ve recently had a heart attack.\n- **Are you having side effects?** Some side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it.\n- **What symptoms are bothering you?** Sometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation.\n- **Have you taken an SSRI before?** If you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again.\n- **Are you pregnant?** If you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the [safer SSRIs](https:\/\/www.uptodate.com\/contents\/depression-treatment-options-for-adults-beyond-the-basics#H3044082849) to use during pregnancy.\n\nKeep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you.\n\nThere are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts, [copay savings cards](https:\/\/www.goodrx.com\/drugs\/savings\/what-are-manufacturer-copay-cards), and [patient assistance programs](https:\/\/www.goodrx.com\/healthcare-access\/patient-advocacy\/what-are-patient-assistance-programs). You can find SSRIs [as low as \\$5](https:\/\/www.goodrx.com\/classes\/ssris) with a free GoodRx discount.\n\nFor many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of [\\$250](https:\/\/www.goodrx.com\/zoloft?label_override=zoloft).\n\n## The bottom line\nThere are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one.\n\n![why trust our exports reliability shield](https:\/\/www.grxstatic.com\/images\/reliability.svg)\n\n![Alex Evans, PharmD, MBA](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1hUSCabcoMdzEp7FxKLLyN\/f08190e47cb3ea4bbd8c8716413a4729\/alex_evans_goodrx.jpg)\n\n![Alex Evans, PharmD, MBA](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1hUSCabcoMdzEp7FxKLLyN\/f08190e47cb3ea4bbd8c8716413a4729\/alex_evans_goodrx.jpg)\n\nAlex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy.\n\n![Sarah Gupta, MD](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1ljb93nV7dT0ERWToKD94t\/d26c54bf4ca8373dabe7240a31e39923\/Sarah-Gupta.webp)\n\n![Sarah Gupta, MD](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/1ljb93nV7dT0ERWToKD94t\/d26c54bf4ca8373dabe7240a31e39923\/Sarah-Gupta.webp)\n\nSarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology.\n\n![Amy B. Gragnolati, PharmD, BCPS](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/5q7aMo8XCWrAzU6I3J4FbK\/01ec68b4535a0858aefcae788642d08d\/Amy_Gragnolati.webp)\n\n![Amy B. Gragnolati, PharmD, BCPS](https:\/\/images.ctfassets.net\/4f3rgqwzdznj\/5q7aMo8XCWrAzU6I3J4FbK\/01ec68b4535a0858aefcae788642d08d\/Amy_Gragnolati.webp)\n\nAmy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California.\n\nGoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https:\/\/www.goodrx.com\/about\/editorial-guidelines).","meta_canonical":null}

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URL	https://www.goodrx.com/classes/ssris/ssri-list
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Meta Title	List of 7 SSRIs (Selective Serotonin Reuptake Inhibitors) - GoodRx
Meta Description	Selective serotonin reuptake inhibitors (SSRIs) are a first-line treatment for anxiety and depression. See a list of SSRIs and their differences to make the best choice for you.
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Boilerpipe Text	Key takeaways: Selective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil). Your medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you. There are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription more affordable . Selective serotonin reuptake inhibitors (SSRIs) are a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re thought to work by increasing availability of a chemical in the brain called serotonin . Common examples of SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil). But with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs. Fluoxetine (Prozac) was approved in 1987 , making it the oldest SSRI available in the U.S. It’s approved to treat: Fluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The DR capsules , which can be taken once weekly, are only approved to treat MDD. Side effects: SSRIs can make some people feel drowsy . But fluoxetine can be more “ activating ,” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take your dose in the morning. Fluoxetine also sticks around longer in your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called discontinuation syndrome ). Interactions: Fluoxetine can interfere with how your body breaks down other medications, resulting in several significant interactions . And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose. Use in pregnancy: SSRIs are generally considered the safer antidepressant options to take during pregnancy. But fluoxetine has been linked to an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant. Sertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for: Read more like this Explore these related articles, suggested for readers like you. View more Sertraline is available as tablets, capsules, and an oral solution. Side effects : Sertraline may be more likely to cause diarrhea than other SSRIs, though this usually goes away within a few weeks. Use during pregnancy : Of the SSRs, sertraline may be one of the safest to take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation. Paroxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension. Pexeva is another form of paroxetine that’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet. Brisdelle is a lower-dose paroxetine capsule that’s specifically approved to treat hot flashes in menopausal women. Side effects : Paroxetine tends to cause more side effects than other SSRIs. These can include weight gain , sexual side effects , and drowsiness. Paxil is also more likely to cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you stop taking it too quickly. But side effects like weight gain and decreased libido may be less likely if you’re taking Brisdelle. Interactions: Paroxetine has several of the same interactions as fluoxetine. And unlike other SSRIs, paroxetine can build up in your body if you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower dosage . Use during pregnancy : Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But several birth defects have been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment. Citalopram (Celexa) is only approved to treat depression. But it’s used off-label to treat several other mental health conditions. It’s available as a tablet, capsule, and oral solution. Side effects: Compared to other SSRIs, citalopram is associated with a higher risk of abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking certain medications that interact with citalopram. Interactions: Compared to other SSRIs, citalopram may be less likely to interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above, interactions are still possible . Escitalopram (Lexapro) is approved to treat MDD and generalized anxiety disorder (GAD). It’s available as a tablet and oral solution. Escitalopram and citalopram are similar, but they’re not the same . Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also more specific to serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram. Side effects : Escitalopram may also have a risk of abnormal heart rhythms, especially if you take doses that are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram. Interactions: Similar to citalopram, escitalopram may have fewer interactions than other SSRIs. Fluvoxamine (Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules. Side effects : All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these side effects more often. And in some clinical studies, more people stopped taking fluvoxamine due to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly. Interactions: Fluvoxamine also has an increased risk of interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can interfere with how caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it. Vilazodone (Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD. Vilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants. Researchers do think this difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure. How you take it: Taking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone should be taken with food. If you take it on an empty stomach, it may not work as well. The best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider. A few considerations may include: Can you swallow pills? If you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions. Do you take other medications? Certain SSRIs, including paroxetine and fluoxetine, have a higher risk of interactions . If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred. Do you have any other health conditions? Your medical history could also influence your choice of SSRI. For example, citalopram may be avoided if you’ve recently had a heart attack. Are you having side effects? Some side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it. What symptoms are bothering you? Sometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation. Have you taken an SSRI before? If you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again. Are you pregnant? If you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the safer SSRIs to use during pregnancy. Keep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you. There are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts, copay savings cards , and patient assistance programs . You can find SSRIs as low as $5 with a free GoodRx discount. For many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of $250 . The bottom line There are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one. Alex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy. Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. Amy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines .
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[SSRIs](https://www.goodrx.com/classes/ssris) SSRIs # Zoloft, Prozac, and More: A List of 7 SSRIs and How They All Compare [![Alex Evans, PharmD, MBA](https://www.grxstatic.com/4f3rgqwzdznj/1hUSCabcoMdzEp7FxKLLyN/f08190e47cb3ea4bbd8c8716413a4729/alex_evans_goodrx.jpg?w=96&q=85&fm=webp)](https://www.goodrx.com/about/bio/alex-evans)[![Sarah Gupta, MD](https://www.grxstatic.com/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp?w=96&q=85&fm=webp)](https://www.goodrx.com/about/bio/sarah-gupta) Written by [Alex Evans, PharmD, MBA](https://www.goodrx.com/about/bio/alex-evans) \\| Reviewed by [Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta), [Amy B. Gragnolati, PharmD, BCPS](https://www.goodrx.com/about/bio/amy-gragnolati) Published on March 10, 2023 ![star](https://www.grxstatic.com/images/star-with-circle.svg)![A woman discusses treatment options with a counselor.](https://www.grxstatic.com/4f3rgqwzdznj/3MQ0Ga0AMhypEoSj7tZDTv/13c98a93b76b34b256877df376d0d2c2/counselor_discussion_1150732827.jpg?w=3840&q=99&fm=webp) FatCamera/E+ + via Getty Images [Fluoxetine](https://www.goodrx.com/classes/ssris/ssri-list#fluoxetine)[Sertraline](https://www.goodrx.com/classes/ssris/ssri-list#sertraline)[Paroxetine](https://www.goodrx.com/classes/ssris/ssri-list#paroxetine)[Citalopram](https://www.goodrx.com/classes/ssris/ssri-list#citalopram)[Escitalopram](https://www.goodrx.com/classes/ssris/ssri-list#escitalopram)[Fluvoxamine](https://www.goodrx.com/classes/ssris/ssri-list#fluvoxamine)[Vilazodone](https://www.goodrx.com/classes/ssris/ssri-list#vilazodone)[Considerations](https://www.goodrx.com/classes/ssris/ssri-list#considerations)[How to save](https://www.goodrx.com/classes/ssris/ssri-list#how-to-save)[Bottom line](https://www.goodrx.com/classes/ssris/ssri-list#bottom-line)[References](https://www.goodrx.com/classes/ssris/ssri-list#references) ## Key takeaways: - Selective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil). - Your medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you. - There are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription [more affordable](https://www.goodrx.com/classes/ssris/ssri-list#how-to-save). #### Save on related medications Promotional Disclosure [prozac](https://www.goodrx.com/prozac "prozac cost and coupons")[fluoxetine](https://www.goodrx.com/fluoxetine "fluoxetine cost and coupons")[escitalopram](https://www.goodrx.com/escitalopram "escitalopram cost and coupons")[lexapro](https://www.goodrx.com/lexapro "lexapro cost and coupons") [Selective serotonin reuptake inhibitors (SSRIs)](https://www.goodrx.com/classes/ssris) are a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re [thought to work](https://www.goodrx.com/classes/ssris/how-ssris-work) by increasing availability of a chemical in the brain called [serotonin](https://www.goodrx.com/health-topic/hormones/serotonin). Common examples of SSRIs include [fluoxetine](https://www.goodrx.com/prozac/what-is) (Prozac), [sertraline](https://www.goodrx.com/zoloft/what-is) (Zoloft), and [paroxetine](https://www.goodrx.com/paroxetine/what-is) (Paxil). But with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs. ## 1\. Fluoxetine Fluoxetine (Prozac) was [approved in 1987](https://meridian.allenpress.com/mhc/article/4/1/11/37061/Antidepressant-medications-The-FDA-approval), making it the oldest SSRI available in the U.S. It’s [approved to treat:](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55) - [Major depressive disorder](https://www.goodrx.com/conditions/depression) (MDD) - [Obsessive-compulsive disorder](https://www.goodrx.com/conditions/obsessive-compulsive-disorder) (OCD) - [Bulimia](https://www.goodrx.com/conditions/eating-disorders/bulimia) - [Panic disorder](https://www.goodrx.com/conditions/panic-disorder) - Depression in [bipolar 1 disorder](https://www.goodrx.com/conditions/bipolar-disorder/bipolar-1-vs-2-differences) - [Premenstrual dysphoric disorder](https://www.goodrx.com/conditions/pmdd) (PMDD) Fluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The [DR capsules](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5), which can be taken once weekly, are only approved to treat MDD. ### Key differences Side effects: SSRIs can make some people feel [drowsy](https://www.goodrx.com/drugs/side-effects/prescription-make-you-tired). But fluoxetine can be more “[activating](https://www.ncbi.nlm.nih.gov/books/NBK459223/),” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take [your dose](https://www.goodrx.com/prozac/dosage) in the morning. Fluoxetine also [sticks around longer](https://www.goodrx.com/prozac/missed-dose-of-prozac) in your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called [discontinuation syndrome](https://www.goodrx.com/classes/atypical-antidepressants/antidepressant-discontinuation-syndrome)). Interactions: Fluoxetine can [interfere with](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20$Table%202$.) how your body breaks down other medications, resulting in several [significant interactions](https://www.goodrx.com/fluoxetine/interactions). And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose. Use in pregnancy: SSRIs are generally considered the [safer antidepressant options](https://www.goodrx.com/conditions/depression/safest-antidepressant-in-pregnancy) to take during pregnancy. But fluoxetine [has been linked](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html) to an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant. ## 2\. Sertraline Sertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for: - Panic disorder - [Post-traumatic stress disorder](https://www.goodrx.com/conditions/ptsd) (PTSD) - [Social anxiety disorder](https://www.goodrx.com/conditions/social-anxiety-disorder) ![Goodrx logo](https://www.grxstatic.com/images/goodrx-logo.svg) ### Read more like this #### Explore these related articles, suggested for readers like you. ![](https://www.grxstatic.com/4f3rgqwzdznj/50AN3uQ5xDRCgRBmafPlz9/cef5b2ddfb33b724dcf1127f8e29dcfe/cropped_portrait_sad_middle_aged_man-672278426.jpg?w=256&q=100&fm=webp) [Can Antidepressants and Anti-Anxiety Drugs Cause Erectile Dysfunction?](https://www.goodrx.com/drugs/side-effects/antidepressants-anti-anxiety-drugs-erectile-dysfunction-side-effect) ![](https://www.grxstatic.com/4f3rgqwzdznj/3n87MtK6CgCp796X2IK914/9e5a9a0fc376d293174f3b3953915f34/closeup_man_drinking_wine_label_1128467471.jpg?w=256&q=100&fm=webp) [Can You Mix Zoloft and Alcohol? The Risks of Drinking with SSRI Antidepressants](https://www.goodrx.com/classes/ssris/can-i-drink-alcohol-while-taking-zoloft) ![](https://www.grxstatic.com/4f3rgqwzdznj/4G3YczsIjg6VY6KLo6ed8I/66f71dd48647878d77ae8085b4a91b35/woman_reading_Rx_bottle_1289796290.jpg?w=256&q=100&fm=webp) [10 Things to Know Before Starting an SNRI Like Cymbalta](https://www.goodrx.com/classes/snris/snri-side-effects) ![](https://www.grxstatic.com/4f3rgqwzdznj/1dZU4vt4qhwSasrHbPms8s/31360330085c813c1e5b28e7d5ae9bf3/tired_in_bed_512896520.webp?w=256&q=100&fm=webp) [10 Paroxetine (Paxil) Side Effects You Should Know About](https://www.goodrx.com/paroxetine/paroxetine-side-effects) View more Sertraline is [available as](https://www.goodrx.com/zoloft/zoloft-dosage) tablets, capsules, and an oral solution. ### Key differences Side effects: Sertraline may be more likely to [cause diarrhea](https://www.goodrx.com/sertraline/common-side-effects) than other SSRIs, though this usually goes away within a few weeks. Use during pregnancy: Of the SSRs, sertraline may be [one of the safest](https://www.goodrx.com/conditions/pregnancy/antidepressants-like-zoloft-prozac) to take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation. ## 3\. Paroxetine Paroxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension. Pexeva is another [form of paroxetine](https://www.goodrx.com/classes/ssris/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better) that’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet. [Brisdelle](https://www.goodrx.com/brisdelle/what-is) is a lower-dose paroxetine capsule that’s specifically approved to [treat hot flashes](https://www.goodrx.com/conditions/menopause/antidepressants-for-menopause) in menopausal women. ### Key differences Side effects: Paroxetine tends to cause [more side effects](https://www.goodrx.com/paroxetine/paroxetine-side-effects) than other SSRIs. These can include [weight gain](https://www.goodrx.com/paroxetine/paroxetine-weight-gain), [sexual side effects](https://www.goodrx.com/conditions/erectile-dysfunction/antidepressants-without-sexual-side-effects), and drowsiness. Paxil is also [more likely](https://www.ncbi.nlm.nih.gov/books/NBK526022/) to cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you [stop taking it](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants) too quickly. But side effects like weight gain and decreased libido [may be less likely](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175016/) if you’re taking Brisdelle. Interactions: Paroxetine has several of the [same interactions](http://www.eurekaselect.com/article/9390) as fluoxetine. And unlike other SSRIs, paroxetine can [build up in your body](https://www.sciencedirect.com/science/article/pii/S2468024916300845) if you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower [dosage](https://www.goodrx.com/paxil/dosage). Use during pregnancy: Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But [several birth defects](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html) have been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment. ## 4\. Citalopram [Citalopram](https://www.goodrx.com/citalopram/what-is) (Celexa) is only approved to treat depression. But it’s used off-label to treat [several other](https://www.ncbi.nlm.nih.gov/books/NBK482222/) mental health conditions. It’s available as a tablet, capsule, and oral solution. ### Key differences Side effects: Compared to other SSRIs, citalopram is associated with a [higher risk](https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.) of abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking [certain medications](https://www.goodrx.com/citalopram/interactions) that interact with citalopram. Interactions: Compared to other SSRIs, citalopram may be [less likely](https://www.mdpi.com/2035-8377/13/3/38) to interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above, [interactions are still possible](https://www.goodrx.com/citalopram/interactions). ## 5\. Escitalopram [Escitalopram](https://www.goodrx.com/lexapro/what-is) (Lexapro) is approved to treat MDD and [generalized anxiety disorder](https://www.goodrx.com/conditions/generalized-anxiety-disorder) (GAD). It’s available as a tablet and oral solution. [Escitalopram and citalopram](https://www.goodrx.com/classes/ssris/celexa-vs-lexapro) are similar, but they’re [not the same](https://www.mdpi.com/2035-8377/13/3/38). Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also [more specific](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315490/) to serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram. ### Key differences Side effects: Escitalopram may also have a risk of abnormal heart rhythms, especially if you [take doses](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15) that are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram. Interactions: Similar to citalopram, escitalopram may have fewer interactions than other SSRIs. ## 6\. Fluvoxamine [Fluvoxamine](https://www.goodrx.com/fluvoxamine/what-is) (Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules. ### Key differences Side effects: All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these [side effects](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/) more often. And in some clinical studies, more people [stopped taking fluvoxamine](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/#:~:text=Fluvoxamine%20is%20associated%20with%20the,and%20sertraline%20$40%25$.) due to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly. Interactions: Fluvoxamine also has an [increased risk](https://www.uspharmacist.com/article/overview-of-drugdrug-interactions-with-ssris) of interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can [interfere with](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884944/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.) how caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it. ## 7\. Vilazodone [Vilazodone](https://www.goodrx.com/viibryd/what-is) (Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD. Vilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants. [Researchers do think](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206504/) this difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure. ### Key differences How you take it: Taking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone should be taken with food. If you take it on an empty stomach, it may not work as well. ## How do I find out which SSRI is right for me? The best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider. A few considerations may include: - Can you swallow pills? If you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions. - Do you take other medications? Certain SSRIs, including paroxetine and fluoxetine, have a higher [risk of interactions](https://www.goodrx.com/classes/ssris/interactions). If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred. - Do you have any other health conditions? Your medical history could also influence your choice of SSRI. For example, citalopram [may be avoided](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8) if you’ve recently had a heart attack. - Are you having side effects? Some side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it. - What symptoms are bothering you? Sometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation. - Have you taken an SSRI before? If you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again. - Are you pregnant? If you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the [safer SSRIs](https://www.uptodate.com/contents/depression-treatment-options-for-adults-beyond-the-basics#H3044082849) to use during pregnancy. Keep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you. ## How to save on SSRIs There are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts, [copay savings cards](https://www.goodrx.com/drugs/savings/what-are-manufacturer-copay-cards), and [patient assistance programs](https://www.goodrx.com/healthcare-access/patient-advocacy/what-are-patient-assistance-programs). You can find SSRIs [as low as \$5](https://www.goodrx.com/classes/ssris) with a free GoodRx discount. For many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of [\$250](https://www.goodrx.com/zoloft?label_override=zoloft). ## The bottom line There are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one. ![why trust our exports reliability shield](https://www.grxstatic.com/images/reliability.svg) ## Why trust our experts? ![Alex Evans, PharmD, MBA](https://images.ctfassets.net/4f3rgqwzdznj/1hUSCabcoMdzEp7FxKLLyN/f08190e47cb3ea4bbd8c8716413a4729/alex_evans_goodrx.jpg) ![Alex Evans, PharmD, MBA](https://images.ctfassets.net/4f3rgqwzdznj/1hUSCabcoMdzEp7FxKLLyN/f08190e47cb3ea4bbd8c8716413a4729/alex_evans_goodrx.jpg) Written by: [Alex Evans, PharmD, MBA](https://www.goodrx.com/about/bio/alex-evans) Alex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy. ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) Reviewed by: [Sarah Gupta, MD](https://www.goodrx.com/about/bio/sarah-gupta) Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. ![Amy B. Gragnolati, PharmD, BCPS](https://images.ctfassets.net/4f3rgqwzdznj/5q7aMo8XCWrAzU6I3J4FbK/01ec68b4535a0858aefcae788642d08d/Amy_Gragnolati.webp) ![Amy B. Gragnolati, PharmD, BCPS](https://images.ctfassets.net/4f3rgqwzdznj/5q7aMo8XCWrAzU6I3J4FbK/01ec68b4535a0858aefcae788642d08d/Amy_Gragnolati.webp) Reviewed by: [Amy B. Gragnolati, PharmD, BCPS](https://www.goodrx.com/about/bio/amy-gragnolati) Amy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California. ![Green trust check mark](https://www.grxstatic.com/images/green-check-mark.svg)[Our editorial standards](https://www.goodrx.com/about/editorial-guidelines) ![Green trust check mark](https://www.grxstatic.com/images/green-check-mark.svg)[Meet our experts](https://www.goodrx.com/about/health#meet-our-healthcare-experts) ## References Brown, C. H. (2008). [Overview of drug-drug interactions with SSRIs](https://www.uspharmacist.com/article/overview-of-drugdrug-interactions-with-ssris). U.S. Pharmacist. Centers for Disease Control and Prevention. (2020). [Key findings—a closer look at the link between specific SSRIs and birth defects](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html). ### View All References (19) Chauhan, M., et al. (2022). [Vilazodone for major Depression in Adults: Pharmacological profile and an updated review for clinical practice](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206504/). Neuropsychiatric Disease and Treatment. Culm-Merdek, K. E., et al. (2005). [Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884944/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.). British Journal of Clinical Pharmacology. Culpepper, L. (2002). [Escitalopram: A new SSRI for the treatment of depression in primary care](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315490/). Primary Care Companion to the Journal of Clinical Psychiatry. DailyMed. (2021). [Escitalopram](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15). DailyMed. (2021). [Fluoxetine hydrochloride](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5). DailyMed. (2022). [Citalopram](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8). DailyMed. (2023). [Fluoxetine](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55). Edinoff, A. N., et al. (2021). [Selective serotonin reuptake inhibitors and adverse effects: A narrative review](https://www.mdpi.com/2035-8377/13/3/38). Neurology International. Ferguson, J. M. (2001). [SSRI Antidepressant Medications: Adverse Effects and Tolerability](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/). Primary Care Companion to the Journal of Clinical Psychiatry. Hanrahan, C., et al. (2014). [Antidepressant medications: The FDA-approval process and the need for updates](https://meridian.allenpress.com/mhc/article/4/1/11/37061/Antidepressant-medications-The-FDA-approval). Mental Health Clinician. Hemeryck, A., et al. (2002). [Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update](https://www.eurekaselect.com/article/9390). Current Drug Metabolism. Marken, P. A., et al. (2000). [Selecting a selective serotonin reuptake inhibitor: Clinically important distinguishing features](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20$Table%202$.). Primary Care Companion to the Journal of Clinical Psychiatry. Portman, D. J., et al. (2014). [Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175016/). Menopause. Rush, A. J. (2023). [Patient education: Depression treatment options for adults (beyond the basics)](https://www.uptodate.com/contents/depression-treatment-options-for-adults-beyond-the-basics#H3044082849). UpToDate. Shirazian, S., et al. (2017). [Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management](https://www.sciencedirect.com/science/article/pii/S2468024916300845). Kidney International Reports. Shoar, N. S., et al. (2021). [Citalopram](https://www.ncbi.nlm.nih.gov/books/NBK482222/). StatPearls. Shrestha, P., et al. (2022). [Paroxetine](https://www.ncbi.nlm.nih.gov/books/NBK526022/). StatPearls. Sohel, A. J., et al. (2022). [Fluoxetine](https://www.ncbi.nlm.nih.gov/books/NBK459223/). StatPearls. U.S. Food and Drug Administration. (2017). [FDA drug safety communication: Revised recommendations for celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses](https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.). GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines). Brown, C. H. (2008). [Overview of drug-drug interactions with SSRIs](https://www.uspharmacist.com/article/overview-of-drugdrug-interactions-with-ssris). U.S. Pharmacist. Centers for Disease Control and Prevention. (2020). [Key findings—a closer look at the link between specific SSRIs and birth defects](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html). Chauhan, M., et al. (2022). [Vilazodone for major Depression in Adults: Pharmacological profile and an updated review for clinical practice](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206504/). Neuropsychiatric Disease and Treatment. Culm-Merdek, K. E., et al. (2005). [Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884944/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.). British Journal of Clinical Pharmacology. Culpepper, L. (2002). [Escitalopram: A new SSRI for the treatment of depression in primary care](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315490/). Primary Care Companion to the Journal of Clinical Psychiatry. DailyMed. (2021). [Escitalopram](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15). DailyMed. (2021). [Fluoxetine hydrochloride](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5). DailyMed. (2022). [Citalopram](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8). DailyMed. (2023). [Fluoxetine](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55). Edinoff, A. N., et al. (2021). [Selective serotonin reuptake inhibitors and adverse effects: A narrative review](https://www.mdpi.com/2035-8377/13/3/38). Neurology International. Ferguson, J. M. (2001). [SSRI Antidepressant Medications: Adverse Effects and Tolerability](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/). Primary Care Companion to the Journal of Clinical Psychiatry. Hanrahan, C., et al. (2014). [Antidepressant medications: The FDA-approval process and the need for updates](https://meridian.allenpress.com/mhc/article/4/1/11/37061/Antidepressant-medications-The-FDA-approval). Mental Health Clinician. Hemeryck, A., et al. (2002). [Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update](https://www.eurekaselect.com/article/9390). Current Drug Metabolism. Marken, P. A., et al. (2000). [Selecting a selective serotonin reuptake inhibitor: Clinically important distinguishing features](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20$Table%202$.). Primary Care Companion to the Journal of Clinical Psychiatry. Portman, D. J., et al. (2014). [Effects of low-dose paroxetine 7.5 mg on weight and sexual function during treatment of vasomotor symptoms associated with menopause](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175016/). Menopause. Rush, A. J. (2023). [Patient education: Depression treatment options for adults (beyond the basics)](https://www.uptodate.com/contents/depression-treatment-options-for-adults-beyond-the-basics#H3044082849). UpToDate. Shirazian, S., et al. (2017). [Depression in chronic kidney disease and end-stage renal disease: Similarities and differences in diagnosis, epidemiology, and management](https://www.sciencedirect.com/science/article/pii/S2468024916300845). Kidney International Reports. Shoar, N. S., et al. (2021). [Citalopram](https://www.ncbi.nlm.nih.gov/books/NBK482222/). StatPearls. Shrestha, P., et al. (2022). [Paroxetine](https://www.ncbi.nlm.nih.gov/books/NBK526022/). StatPearls. Sohel, A. J., et al. (2022). [Fluoxetine](https://www.ncbi.nlm.nih.gov/books/NBK459223/). StatPearls. U.S. Food and Drug Administration. (2017). [FDA drug safety communication: Revised recommendations for celexa (citalopram hydrobromide) related to a potential risk of abnormal heart rhythms with high doses](https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.). ![Newsletter Subscription](https://www.grxstatic.com/images/notification-email-female.svg) #### Subscribe and save Get prescription saving tips and more from GoodRx Health. Enter your email to sign up ### Latest articles [![Health: SSRIs: closeup man drinking wine label 1128467471](https://www.grxstatic.com/4f3rgqwzdznj/3n87MtK6CgCp796X2IK914/9e5a9a0fc376d293174f3b3953915f34/closeup_man_drinking_wine_label_1128467471.jpg?w=640&q=85&fm=webp) SSRIs Can You Mix Zoloft and Alcohol? 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Written by Nidhi Gandhi-Patel, PharmD, BSUpdated on Apr 14, 2023 by Nidhi Gandhi-Patel, PharmD, BS • Apr 14, 2023](https://www.goodrx.com/classes/ssris/are-zoloft-prozac-ssris-safe-while-breastfeeding) [![SSRIs: cropped doctor patient discussing two pill bottles 1397290480](https://www.grxstatic.com/4f3rgqwzdznj/4Ml2PlcBUrjkbA8DnQVo1c/9a043aabfbfc47bc7226b34e41040955/cropped_doctor_patient_discussing_two_pill_bottles_1397290480.jpg?w=640&q=85&fm=webp) SSRIs Paxil vs. Pexeva for Depression: Which Is Best? Written by Christina Aungst, PharmDUpdated on Jan 18, 2023 by Christina Aungst, PharmD • Jan 18, 2023](https://www.goodrx.com/classes/ssris/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better) [![SSRIS: Celexa vs Lexapro: sad woman looking out window-1319976569](https://www.grxstatic.com/4f3rgqwzdznj/2AslvnphS0swYu3mHBKPiu/cb9208c652eef4d69491d9d0e1712c09/sad_woman_looking_out_window-1319976569.jpg?w=640&q=85&fm=webp) SSRIs Celexa vs. Lexapro for Depression Written by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMPPublished on Jun 10, 2022 by Nicole E. Cieri-Hutcherson, PharmD, BCPS, NCMP • Jun 10, 2022](https://www.goodrx.com/classes/ssris/celexa-vs-lexapro) View more ##### Subscribe and save Get prescription saving tips and more from GoodRx Health. 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Readable Markdown	## Key takeaways: - Selective serotonin reuptake inhibitors (SSRIs) are common medications used to treat mental health conditions, like depression and anxiety. Examples include sertraline (Zoloft), fluoxetine (Prozac), and paroxetine (Paxil). - Your medical history, other medications you’re taking, and side effects are a few considerations when choosing the right SSRI for you. - There are many ways to save on your SSRI medication. Many options are available as lower-cost generics or have copay savings opportunities. GoodRx can help make your prescription [more affordable](https://www.goodrx.com/classes/ssris/ssri-list#how-to-save). [Selective serotonin reuptake inhibitors (SSRIs)](https://www.goodrx.com/classes/ssris) are a class of medications commonly used to treat depression, anxiety, and other mood disorders. They’re [thought to work](https://www.goodrx.com/classes/ssris/how-ssris-work) by increasing availability of a chemical in the brain called [serotonin](https://www.goodrx.com/health-topic/hormones/serotonin). Common examples of SSRIs include [fluoxetine](https://www.goodrx.com/prozac/what-is) (Prozac), [sertraline](https://www.goodrx.com/zoloft/what-is) (Zoloft), and [paroxetine](https://www.goodrx.com/paroxetine/what-is) (Paxil). But with several SSRIs available, how do you choose? Ultimately, the right SSRI for you depends on your symptoms, side effects, and other factors. And in some cases, you may need to try more than one. Below we highlight a few of the key differences between SSRIs. Fluoxetine (Prozac) was [approved in 1987](https://meridian.allenpress.com/mhc/article/4/1/11/37061/Antidepressant-medications-The-FDA-approval), making it the oldest SSRI available in the U.S. It’s [approved to treat:](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6b9c2d73-866b-44c4-8718-e7e4a9a0fb55) Fluoxetine is available as an immediate-release (IR) and delayed-release (DR) capsule. You can also find it as an IR tablet and oral solution. The [DR capsules](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=887fc670-db67-4cfe-967b-46b38375dae5), which can be taken once weekly, are only approved to treat MDD. Side effects: SSRIs can make some people feel [drowsy](https://www.goodrx.com/drugs/side-effects/prescription-make-you-tired). But fluoxetine can be more “[activating](https://www.ncbi.nlm.nih.gov/books/NBK459223/),” meaning you may feel anxious and have difficulty sleeping. If it’s keeping you awake at night, you may be told to take [your dose](https://www.goodrx.com/prozac/dosage) in the morning. Fluoxetine also [sticks around longer](https://www.goodrx.com/prozac/missed-dose-of-prozac) in your body than other SSRIs. So, there’s a lower risk of withdrawal symptoms (called [discontinuation syndrome](https://www.goodrx.com/classes/atypical-antidepressants/antidepressant-discontinuation-syndrome)). Interactions: Fluoxetine can [interfere with](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181142/#:~:text=All%20of%20the%20SSRIs%20are,of%20the%20major%20P450%20enzymes.&text=Therefore%2C%20these%20agents%20have%20the,of%20medications%20$Table%202$.) how your body breaks down other medications, resulting in several [significant interactions](https://www.goodrx.com/fluoxetine/interactions). And since fluoxetine lasts longer in your body, some interactions can still be an issue for several weeks after your last dose. Use in pregnancy: SSRIs are generally considered the [safer antidepressant options](https://www.goodrx.com/conditions/depression/safest-antidepressant-in-pregnancy) to take during pregnancy. But fluoxetine [has been linked](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html) to an increased risk of certain birth defects. However, the overall risk of these birth defects is very low. Talk to your healthcare provider about your options if you become pregnant or if you’re trying to get pregnant. Sertraline (Zoloft) is used to treat several of the same mental health conditions as Prozac. In addition to MDD, OCD, and PMDD, sertraline is approved for: ![Goodrx logo](https://www.grxstatic.com/images/goodrx-logo.svg) Read more like thisExplore these related articles, suggested for readers like you. ![](https://www.grxstatic.com/4f3rgqwzdznj/50AN3uQ5xDRCgRBmafPlz9/cef5b2ddfb33b724dcf1127f8e29dcfe/cropped_portrait_sad_middle_aged_man-672278426.jpg?w=256&q=100&fm=webp) ![](https://www.grxstatic.com/4f3rgqwzdznj/3n87MtK6CgCp796X2IK914/9e5a9a0fc376d293174f3b3953915f34/closeup_man_drinking_wine_label_1128467471.jpg?w=256&q=100&fm=webp) ![](https://www.grxstatic.com/4f3rgqwzdznj/4G3YczsIjg6VY6KLo6ed8I/66f71dd48647878d77ae8085b4a91b35/woman_reading_Rx_bottle_1289796290.jpg?w=256&q=100&fm=webp) View more Sertraline is [available as](https://www.goodrx.com/zoloft/zoloft-dosage) tablets, capsules, and an oral solution. Side effects: Sertraline may be more likely to [cause diarrhea](https://www.goodrx.com/sertraline/common-side-effects) than other SSRIs, though this usually goes away within a few weeks. Use during pregnancy: Of the SSRs, sertraline may be [one of the safest](https://www.goodrx.com/conditions/pregnancy/antidepressants-like-zoloft-prozac) to take during pregnancy. Even so, it’s not without potential risks. Your healthcare provider can help you determine if it’s best for your situation. Paroxetine (Paxil, Paxil CR) is approved to treat most of the conditions we’ve covered so far. It’s available as IR and ER tablets, and as an oral suspension. Pexeva is another [form of paroxetine](https://www.goodrx.com/classes/ssris/paxil-vs-pexeva-which-paroxetine-antidepressant-is-better) that’s approved to treat many of the same conditions as Paxil. It’s only available as an IR tablet. [Brisdelle](https://www.goodrx.com/brisdelle/what-is) is a lower-dose paroxetine capsule that’s specifically approved to [treat hot flashes](https://www.goodrx.com/conditions/menopause/antidepressants-for-menopause) in menopausal women. Side effects: Paroxetine tends to cause [more side effects](https://www.goodrx.com/paroxetine/paroxetine-side-effects) than other SSRIs. These can include [weight gain](https://www.goodrx.com/paroxetine/paroxetine-weight-gain), [sexual side effects](https://www.goodrx.com/conditions/erectile-dysfunction/antidepressants-without-sexual-side-effects), and drowsiness. Paxil is also [more likely](https://www.ncbi.nlm.nih.gov/books/NBK526022/) to cause discontinuation syndrome (withdrawal) than other SSRIs — especially if you [stop taking it](https://www.goodrx.com/conditions/depression/how-to-get-off-antidepressants) too quickly. But side effects like weight gain and decreased libido [may be less likely](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175016/) if you’re taking Brisdelle. Interactions: Paroxetine has several of the [same interactions](http://www.eurekaselect.com/article/9390) as fluoxetine. And unlike other SSRIs, paroxetine can [build up in your body](https://www.sciencedirect.com/science/article/pii/S2468024916300845) if you have mild to severe kidney disease. Depending on your kidney function, you may need to take a lower [dosage](https://www.goodrx.com/paxil/dosage). Use during pregnancy: Overall, the risks associated with taking SSRIs during pregnancy appear to be low. But [several birth defects](https://www.cdc.gov/pregnancy/meds/treatingfortwo/features/ssrisandbirthdefects.html) have been linked to paroxetine in particular. Your healthcare provider can help you weigh the pros and cons of continuing, stopping, or switching treatment. [Citalopram](https://www.goodrx.com/citalopram/what-is) (Celexa) is only approved to treat depression. But it’s used off-label to treat [several other](https://www.ncbi.nlm.nih.gov/books/NBK482222/) mental health conditions. It’s available as a tablet, capsule, and oral solution. Side effects: Compared to other SSRIs, citalopram is associated with a [higher risk](https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-revised-recommendations-celexa-citalopram-hydrobromide-related#:~:text=Citalopram%20causes%20dose-dependent%20QT,and%20confer%20no%20additional%20benefit.) of abnormal heart rhythms, especially if you’re taking higher doses. Because of this, certain people may need to take a lower dosage. Examples include adults over age 60, people with liver problems, and those taking [certain medications](https://www.goodrx.com/citalopram/interactions) that interact with citalopram. Interactions: Compared to other SSRIs, citalopram may be [less likely](https://www.mdpi.com/2035-8377/13/3/38) to interfere with how your body breaks down other medications. So, citalopram may have fewer interactions than other SSRIs. But as mentioned above, [interactions are still possible](https://www.goodrx.com/citalopram/interactions). [Escitalopram](https://www.goodrx.com/lexapro/what-is) (Lexapro) is approved to treat MDD and [generalized anxiety disorder](https://www.goodrx.com/conditions/generalized-anxiety-disorder) (GAD). It’s available as a tablet and oral solution. [Escitalopram and citalopram](https://www.goodrx.com/classes/ssris/celexa-vs-lexapro) are similar, but they’re [not the same](https://www.mdpi.com/2035-8377/13/3/38). Citalopram is made of two parts: an active compound and an inactive compound. Escitalopram only contains the active compound. Its effects are also [more specific](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC315490/) to serotonin. In theory, this is thought to lower the risk of certain side effects normally associated with taking citalopram. Side effects: Escitalopram may also have a risk of abnormal heart rhythms, especially if you [take doses](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a98f0040-e8e4-464e-a6fb-1ece98213497#s15) that are higher than recommended. But the risk of abnormal heart rhythms appears to be much lower than citalopram. Interactions: Similar to citalopram, escitalopram may have fewer interactions than other SSRIs. [Fluvoxamine](https://www.goodrx.com/fluvoxamine/what-is) (Luvox) is an SSRI medication approved for OCD. It’s available as IR tablets and ER capsules. Side effects: All SSRIs can cause nausea and diarrhea. But fluvoxamine tends to cause these [side effects](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/) more often. And in some clinical studies, more people [stopped taking fluvoxamine](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/#:~:text=Fluvoxamine%20is%20associated%20with%20the,and%20sertraline%20$40%25$.) due to side effects than with other SSRIs. And, like paroxetine, it’s one of the SSRIs that’s more likely to cause discontinuation syndrome if you stop it abruptly. Interactions: Fluvoxamine also has an [increased risk](https://www.uspharmacist.com/article/overview-of-drugdrug-interactions-with-ssris) of interactions. This includes a few that may be different from other SSRIs. For example, fluvoxamine can [interfere with](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884944/#:~:text=Coadministration%20of%20fluvoxamine%20impairs%20the,inhibition%20of%20CYP1A2%20by%20fluvoxamine.) how caffeine is broken down in your body. So, you may need to be cautious with your caffeine intake while taking it. [Vilazodone](https://www.goodrx.com/viibryd/what-is) (Viibryd) is the most recent SSRI to be approved in the U.S. It’s available as an oral tablet that’s approved to treat MDD. Vilazodone is the only SSRI on this list that affects serotonin in two different ways to relieve depression symptoms. Though, we still don’t know if this difference makes it work better than other antidepressants. [Researchers do think](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206504/) this difference might lessen certain side effects — like sexual effects and weight gain — but more research is needed to know for sure. How you take it: Taking your SSRI with food can help with side effects like nausea. But for most SSRIs, you can take your dose with or without food. However, vilazodone should be taken with food. If you take it on an empty stomach, it may not work as well. The best SSRI for you often comes down to several factors. Side effects, interactions, and medical history are a few things your healthcare provider may consider. A few considerations may include: - Can you swallow pills? If you have difficulty swallowing pills, most SSRIs are available as a liquid. Fluvoxamine and vilazodone are two exceptions. - Do you take other medications? Certain SSRIs, including paroxetine and fluoxetine, have a higher [risk of interactions](https://www.goodrx.com/classes/ssris/interactions). If you’re taking several medications, other SSRIs like citalopram or escitalopram may be preferred. - Do you have any other health conditions? Your medical history could also influence your choice of SSRI. For example, citalopram [may be avoided](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2632b547-2e13-447f-ac85-c774e437d6a8) if you’ve recently had a heart attack. - Are you having side effects? Some side effects may be more likely with certain SSRIs. If a particular side effect starts affecting your quality of life, there may be another SSRI that’s less likely to cause it. - What symptoms are bothering you? Sometimes an SSRI is chosen because its side effects may help your symptoms. For example, a more sedating SSRI may be helpful if you’re experiencing agitation. - Have you taken an SSRI before? If you’ve taken an SSRI in the past, and it’s helped you, your provider might recommend trying the same one again. - Are you pregnant? If you’re pregnant or trying to conceive, your provider might recommend sertraline or citalopram. Experts consider these to be two of the [safer SSRIs](https://www.uptodate.com/contents/depression-treatment-options-for-adults-beyond-the-basics#H3044082849) to use during pregnancy. Keep in mind that SSRIs affect everyone differently. And you may need to try more than one before finding the best fit for you. There are many ways to save on your SSRI medication. GoodRx can help you navigate your options, which may include GoodRx discounts, [copay savings cards](https://www.goodrx.com/drugs/savings/what-are-manufacturer-copay-cards), and [patient assistance programs](https://www.goodrx.com/healthcare-access/patient-advocacy/what-are-patient-assistance-programs). You can find SSRIs [as low as \$5](https://www.goodrx.com/classes/ssris) with a free GoodRx discount. For many people, filling a generic SSRI is the most affordable option. But savings on certain brand-name products are also available. For instance, anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of brand-name Zoloft at an exclusive cash price of [\$250](https://www.goodrx.com/zoloft?label_override=zoloft). ## The bottom line There are several SSRI options available. Examples include fluoxetine, paroxetine, and sertraline. The right one for you can depend on your specific symptoms, health history, and other factors. If one SSRI isn’t a good fit, you may find success with a different one. ![why trust our exports reliability shield](https://www.grxstatic.com/images/reliability.svg) ![Alex Evans, PharmD, MBA](https://images.ctfassets.net/4f3rgqwzdznj/1hUSCabcoMdzEp7FxKLLyN/f08190e47cb3ea4bbd8c8716413a4729/alex_evans_goodrx.jpg) ![Alex Evans, PharmD, MBA](https://images.ctfassets.net/4f3rgqwzdznj/1hUSCabcoMdzEp7FxKLLyN/f08190e47cb3ea4bbd8c8716413a4729/alex_evans_goodrx.jpg) Alex Evans, PharmD, MBA, has been a pharmacist for 12 years. His first job was floating in a community chain pharmacy. ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) ![Sarah Gupta, MD](https://images.ctfassets.net/4f3rgqwzdznj/1ljb93nV7dT0ERWToKD94t/d26c54bf4ca8373dabe7240a31e39923/Sarah-Gupta.webp) Sarah Gupta, MD, is a licensed physician with a special interest in mental health, sex and gender, eating disorders, and the human microbiome. She is currently board certified by the American Board of Psychiatry and Neurology. ![Amy B. Gragnolati, PharmD, BCPS](https://images.ctfassets.net/4f3rgqwzdznj/5q7aMo8XCWrAzU6I3J4FbK/01ec68b4535a0858aefcae788642d08d/Amy_Gragnolati.webp) ![Amy B. Gragnolati, PharmD, BCPS](https://images.ctfassets.net/4f3rgqwzdznj/5q7aMo8XCWrAzU6I3J4FbK/01ec68b4535a0858aefcae788642d08d/Amy_Gragnolati.webp) Amy Gragnolati, PharmD, BCPS, is a pharmacy editor for GoodRx. Amy currently holds her pharmacist license in Georgia and California. GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our [editorial guidelines](https://www.goodrx.com/about/editorial-guidelines).
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