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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 157 (from laksa182)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa157.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics","crawl_time":1773958411,"first_indexed_time":1642799332,"http_code":200,"src_unparsed":"com,foxnews!www,\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics s443","src_root_hash":"1511671639469378157","history_drop_reason":null,"meta_title":"COVID-19 lingering loss of taste or smell may be explained by genetics, study finds | Fox News","meta_descriptions":["The mystery of why people infected with COVID-19 lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature Genetics."],"attrs_boilerpipe_text":"The mystery of why people infected with\nCOVID-19\nlose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature\nGenetics\n.\n\"How we get from infection to smell loss remains unclear,\" said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt\nUniversity\nin\nNashville, Tenn.\n, who was not part of the\nstudy.\nResearchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the\nUnited States\nand\nUnited Kingdom\nwho took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not.\nAmong those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the\nstudy.\nFILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. \n(AP Photo\/Kyle Green, File)\nCOVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT \nThe study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of\nEuropean\nancestry\n.\nThe research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19.\nEven though past\nanimal\nstudies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they \" … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to\nsmell\n.\"\nDespite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants\n,\nand the inability to \"disentangle\" the loss of taste with smell because both were included in a single survey question.\n\"Notably, the [gene] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection,\" the authors\nsaid\n.\nFILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo\/Jae C. Hong, File) \n(AP)\nCLICK HERE TO GET THE FOX NEWS APP\nPrevious research has shown the loss of taste and smell is related to a \"failure to protect the sensory cells of the nose and tongue from viral infection,\" said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the\nstudy\n.\n\"This study suggests a different direction,\" she noted. \"The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell.","attrs_markdown":"- Fox News Media\n- [Fox News Media](https:\/\/www.foxnews.com\/)\n- [Fox Business](https:\/\/www.foxbusiness.com\/)\n- [Fox Nation](https:\/\/nation.foxnews.com\/)\n- [Fox News Audio](https:\/\/radio.foxnews.com\/)\n- [Fox Weather](https:\/\/www.foxweather.com\/)\n- [Outkick](https:\/\/www.outkick.com\/)\n- [Fox Noticias](https:\/\/noticias.foxnews.com\/)\n- [Books](https:\/\/www.foxnews.com\/books)\n\n[Fox News](https:\/\/www.foxnews.com\/ \"Breaking News Today Fox News\")\n\n- [U.S.](https:\/\/www.foxnews.com\/us)\n  - [Blue City Crime](https:\/\/www.foxnews.com\/category\/us\/blue-city-crime)\n  - [Campus Radicals](https:\/\/www.foxnews.com\/category\/us\/campus-radicals)\n  - 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reported in major city: ‘Life-threatening’](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-in-hospital-getting-treatment.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/first-case-severe-mpox-disease-reported-major-city-life-threatening)\n  [First case of severe mpox disease reported in major city: ‘Life-threatening’](https:\/\/www.foxnews.com\/health\/first-case-severe-mpox-disease-reported-major-city-life-threatening)\n- [![Patient in Canada waits over 12 hours in hospital emergency room: 'I'd rather pay’](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/patient-waiting-canada-hospital.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/patient-canada-waits-over-12-hours-hospital-emergency-room-id-rather-pay)\n  [Patient in Canada waits over 12 hours in hospital emergency room: 'I'd rather pay’](https:\/\/www.foxnews.com\/health\/patient-canada-waits-over-12-hours-hospital-emergency-room-id-rather-pay)\n- [![Common vitamin could bring relief from long COVID symptoms, study suggests](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-holding-supplements-hand.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/common-vitamin-could-bring-relief-from-long-covid-symptoms-study-suggests)\n  [Common vitamin could bring relief from long COVID symptoms, study suggests](https:\/\/www.foxnews.com\/health\/common-vitamin-could-bring-relief-from-long-covid-symptoms-study-suggests)\n- [![The real reason for sagging jowls, and what will and won't help, according to an expert](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-sagging-jowls-mirror.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/real-reason-sagging-jowls-what-wont-help-according-expert)\n  [The real reason for sagging jowls, and what will and won't help, according to an expert](https:\/\/www.foxnews.com\/health\/real-reason-sagging-jowls-what-wont-help-according-expert)\n- [![Cigarette smoking in America plummets to historic single-digit low, new study finds](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/snuffing-out-cigarette-butt.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/smoking-rate-america-has-plummeted-record-low)\n  [Cigarette smoking in America plummets to historic single-digit low, new study finds](https:\/\/www.foxnews.com\/health\/smoking-rate-america-has-plummeted-record-low)\n- [![Woman's alarming cancer symptoms blamed on pregnancy for years before Stage 3 diagnosis](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/marisa-peters-colorectal-cancer-flags.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/womans-alarming-cancer-symptoms-blamed-pregnancy-years-before-stage-3-diagnosis)\n  [Woman's alarming cancer symptoms blamed on pregnancy for years before Stage 3 diagnosis](https:\/\/www.foxnews.com\/health\/womans-alarming-cancer-symptoms-blamed-pregnancy-years-before-stage-3-diagnosis)\n- [![Sleep remedy dubbed ‘nature’s Valium’ sparks debate among experts](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/hands-holding-valerian-flower.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/sleep-remedy-dubbed-natures-valium-sparks-debate-among-experts)\n  [Sleep remedy dubbed ‘nature’s Valium’ sparks debate among experts](https:\/\/www.foxnews.com\/health\/sleep-remedy-dubbed-natures-valium-sparks-debate-among-experts)\n- [![Sugary drinks linked to higher anxiety risk in certain age group, study finds](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-holding-sugar-sweetened-drink.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/sugary-drinks-linked-higher-anxiety-risk-certain-age-group-study-finds)\n  [Sugary drinks linked to higher anxiety risk in certain age group, study finds](https:\/\/www.foxnews.com\/health\/sugary-drinks-linked-higher-anxiety-risk-certain-age-group-study-finds)\n- [![Toxic people in your life may have a hidden health impact, study suggests](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/older-couple-arguing-toxic-relationships.png?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/toxic-people-your-life-may-have-hidden-health-impact-study-suggests)\n  [Toxic people in your life may have a hidden health impact, study suggests](https:\/\/www.foxnews.com\/health\/toxic-people-your-life-may-have-hidden-health-impact-study-suggests)\n- [![Aging could slow down with one common daily habit: 'Live longer and better'](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-shopping-for-vitamins.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/aging-could-slow-down-one-common-daily-habit-live-longer-better)\n  [Aging could slow down with one common daily habit: 'Live longer and better'](https:\/\/www.foxnews.com\/health\/aging-could-slow-down-one-common-daily-habit-live-longer-better)\n- [![Red flags for colorectal cancer that warrant screenings before 45 years of age](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/man-holding-stomach-colon-cancer-sign.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/red-flags-colorectal-cancer-warrant-screenings-before-45-years-age)\n  [Red flags for colorectal cancer that warrant screenings before 45 years of age](https:\/\/www.foxnews.com\/health\/red-flags-colorectal-cancer-warrant-screenings-before-45-years-age)\n- [![Nearly half of seniors improve with age — and researchers think they know why](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/older-woman.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/nearly-half-seniors-improve-age-researchers-think-know-why)\n  [Nearly half of seniors improve with age — and researchers think they know why](https:\/\/www.foxnews.com\/health\/nearly-half-seniors-improve-age-researchers-think-know-why)\n- [![Male fertility rates crash as doctors reveal health threats: 'Something very wrong'](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/couple-holding-hands-fertility-doctor.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/male-fertility-rates-crash-doctors-reveal-health-threats-something-very-wrong)\n  [Male fertility rates crash as doctors reveal health threats: 'Something very wrong'](https:\/\/www.foxnews.com\/health\/male-fertility-rates-crash-doctors-reveal-health-threats-something-very-wrong)\n- [![Lurking dementia risk exposed by breakthrough test 25 years before symptoms](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2026\/03\/320\/180\/woman-looking-concerned-dementia-risk.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/health\/lurking-dementia-risk-exposed-breakthrough-test-25-years-before-symptoms)\n  [Lurking dementia risk exposed by breakthrough test 25 years before symptoms](https:\/\/www.foxnews.com\/health\/lurking-dementia-risk-exposed-breakthrough-test-25-years-before-symptoms)\n\nRight Arrow\n\nLeft Arrow\n\n- [![Father claims court ignored autism diagnosis in ruling on 11-year-old son’s sex change](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/5f954b29-d2dc-4201-a3ea-1156cf813c46\/d0870b9d-70f4-4951-b815-955851ddedc9\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391194223112)\n  [Father claims court ignored autism diagnosis in ruling on 11-year-old son’s sex change](https:\/\/www.foxnews.com\/video\/6391194223112)\n- [![Wim Hof breaks down his three-pillar method for more energy, less stress](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/e8667ab3-ea56-4664-915c-6c51221eb038\/39ceb95f-f5b0-43b4-8c57-a8d9bca44d0a\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391178641112)\n  [Wim Hof breaks down his three-pillar method for more energy, less stress](https:\/\/www.foxnews.com\/video\/6391178641112)\n- [![Wim Hof shares how cold training can help the body heal from chronic stress](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/625b095c-5aa1-42ee-9d63-7e3acceadc28\/cae1c025-d181-4c2a-8b76-3cb4acd590b2\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391150798112)\n  [Wim Hof shares how cold training can help the body heal from chronic stress](https:\/\/www.foxnews.com\/video\/6391150798112)\n- [![Medicaid spending surges as Trump administration tightens oversight](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/b83408de-c4c2-47ad-bf13-4bcb7bb03ac1\/8ddb419d-9f17-4434-9c42-d4af54a14c43\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391137543112)\n  [Medicaid spending surges as Trump administration tightens oversight](https:\/\/www.foxnews.com\/video\/6391137543112)\n- [![Wellness businesses skyrocket as Americans prioritize health](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/87eb272d-0b46-4cc9-9512-7adf45c8077e\/e6744e0a-d3a5-40f4-8b1f-0e96e412d90a\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391118999112)\n  [Wellness businesses skyrocket as Americans prioritize health](https:\/\/www.foxnews.com\/video\/6391118999112)\n- [![Mom with stage 4 colorectal cancer credits uncommon surgery for her survival](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/411a3a51-1164-4dec-a677-7a2e6617a12a\/b0e158be-cfff-4d30-915b-3c893ed796d6\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391107318112)\n  [Mom with stage 4 colorectal cancer credits uncommon surgery for her survival](https:\/\/www.foxnews.com\/video\/6391107318112)\n- [![Trump chief of staff Susie Wiles announces breast cancer diagnosis](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/13e30560-239f-4f2a-a80a-20287de61677\/92e5c163-d8de-4edd-9a34-818cf50f300e\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391026477112)\n  [Trump chief of staff Susie Wiles announces breast cancer diagnosis](https:\/\/www.foxnews.com\/video\/6391026477112)\n- [![Trump hails 'fantastic' Susie Wiles after cancer diagnosis](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/d537c682-35ce-468b-bb64-a13aed168448\/ff7d759f-4146-4a57-9a04-081557f57aba\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391023048112)\n  [Trump hails 'fantastic' Susie Wiles after cancer diagnosis](https:\/\/www.foxnews.com\/video\/6391023048112)\n- [![BREAKING: Susie Wiles diagnosed with early stage breast cancer](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/6d8c32bc-bb44-45dd-917f-a077f81d8ef1\/9d54e310-ff4a-4d57-81f5-e0ca608daaf3\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391022822112)\n  [BREAKING: Susie Wiles diagnosed with early stage breast cancer](https:\/\/www.foxnews.com\/video\/6391022822112)\n- [![US cigarette smoking drops to record low, vaping and nicotine pouch use surges](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/55068c5e-e8a1-448c-ad5c-4c3e788e6c70\/1c15e0d4-bc48-4897-904f-b758942963ed\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6391013339112)\n  [US cigarette smoking drops to record low, vaping and nicotine pouch use surges](https:\/\/www.foxnews.com\/video\/6391013339112)\n- [![Canadian patients left waiting 15+ hours in emergency room, video shows](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/9b5cf515-2651-4426-8c0e-a6ca7a4f6565\/4a04f419-4708-4abe-9aae-14c5264e92b7\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390395644112)\n  [Canadian patients left waiting 15+ hours in emergency room, video shows](https:\/\/www.foxnews.com\/video\/6390395644112)\n- [![Dermatologist reveals why sagging jowls appear seemingly overnight and what causes them](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/48f5d367-7666-42b0-b9e9-b27541e1a000\/898423ac-993e-45ac-a836-349e927688e1\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390508471112)\n  [Dermatologist reveals why sagging jowls appear seemingly overnight and what causes them](https:\/\/www.foxnews.com\/video\/6390508471112)\n- [![Welcome to Medicaid’s biggest fraud](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/3c9bd547-2a3c-44ab-a20e-f0c10f8d268d\/8cabcff5-6b06-4901-95d6-20fd20414ac5\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390940516112)\n  [Welcome to Medicaid’s biggest fraud](https:\/\/www.foxnews.com\/video\/6390940516112)\n- [![New Bostonian phone booth lets you 'CALL A BOOMER'](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/d35eefed-f46b-4d84-b6ec-16c82ad39a8c\/d74a652b-dffb-4f1a-9d91-63639df9e131\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390924766112)\n  [New Bostonian phone booth lets you 'CALL A BOOMER'](https:\/\/www.foxnews.com\/video\/6390924766112)\n- [![White House advisor calls for food pyramid reform to lower healthcare costs](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/55d750cb-eef9-45f9-8c8f-cc734d6126ba\/fbfb258a-f0c6-4b94-92d7-c93bb6e4ea11\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390921039112)\n  [White House advisor calls for food pyramid reform to lower healthcare costs](https:\/\/www.foxnews.com\/video\/6390921039112)\n- [![Colorectal cancer survivor says symptoms were dismissed for years before diagnosis](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/7ad02810-3c13-4bb2-a913-7e94eea61523\/fe32f015-dce8-4655-bb5c-9e74681ba2be\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390882116112)\n  [Colorectal cancer survivor says symptoms were dismissed for years before diagnosis](https:\/\/www.foxnews.com\/video\/6390882116112)\n- [![NJ teen desperately seeking help to find kidney donor](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/989f4cbb-3fb9-4eb4-af89-df7907ebb35d\/50ca65f7-59b1-4ac3-9e0a-e036ec6e3bf3\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390783489112)\n  [NJ teen desperately seeking help to find kidney donor](https:\/\/www.foxnews.com\/video\/6390783489112)\n- [![President Trump touts plan to lower drug prices for working families](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/7acb8721-dd03-46b1-96a4-bb56842ebfab\/d424d9e0-fa39-4030-8a10-e24ad1b805f3\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390749746112)\n  [President Trump touts plan to lower drug prices for working families](https:\/\/www.foxnews.com\/video\/6390749746112)\n- [![Childhood obesity surges across US, experts point to ultra-processed food](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/e39f1b5d-0d51-4a1a-94ac-4cbdd538cf6a\/d92eaef6-178f-4767-b38e-ef0637ad0eb3\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390626105112)\n  [Childhood obesity surges across US, experts point to ultra-processed food](https:\/\/www.foxnews.com\/video\/6390626105112)\n- [![California firefighter shares tips for living longer amid job hazards](https:\/\/a57.foxnews.com\/cf-images.us-east-1.prod.boltdns.net\/v1\/static\/694940094001\/b0dfe245-bdd2-4c2e-961c-9065e5fc0cd9\/3eb1e58c-3ed4-4a95-8836-9169cae1d3ad\/1280x720\/match\/320\/180\/image.jpg?ve=1&tl=1)](https:\/\/www.foxnews.com\/video\/6390614897112)\n  [California firefighter shares tips for living longer amid job hazards](https:\/\/www.foxnews.com\/video\/6390614897112)\n\nRight Arrow\n\n[Coronavirus](https:\/\/www.foxnews.com\/category\/health\/infectious-disease\/coronavirus)\n\n# COVID-19 lingering loss of taste or smell may be explained by genetics, study finds\n## Research from 23andme found that female respondents were 11% more likely to lose their sense of taste and smell out of almost 70,000 people\n\nBy [Shiv Sudhakar](https:\/\/www.foxnews.com\/person\/s\/shiv-sudhakar)  [Fox News](https:\/\/www.foxnews.com\/)\n\nPublished\n\n[January 21, 2022 4:05pm EST](https:\/\/www.foxnews.com\/html-sitemap\/2022\/january\/21)\n\n- [Facebook](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n- [Twitter](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n- [Threads](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n- [Flipboard](https:\/\/share.flipboard.com\/bookmarklet\/popout?v=2&title=COVID-19%20lingering%20loss%20of%20taste%20or%20smell%20may%20be%20explained%20by%20genetics%2C%20study%20finds%20%7C%20Fox%20News&url=https%3A%2F%2Fwww.foxnews.com%2Fhealth%2Fcovid-19-sequalae-loss-taste-smell-explained-genetics&t=1773958413385&utm_campaign=tools&utm_medium=article-share&utm_source=www.foxnews.com)\n- [Comments](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n- [Print](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics.print)\n- [Email](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n- [Add Fox News on Google](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n\n[close](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n\n#### [Va. governor's decision to lift COVID mask mandate will 'confirm that parents matter': Jason Miyares](https:\/\/www.foxnews.com\/video\/6292959021001)\nVirginia attorney general gives his take on Gov. Glenn Youngkin allowing a mask mandate opt-out on 'America Reports.'\n\nThe mystery of why people infected with [COVID-19](https:\/\/www.foxnews.com\/category\/health\/infectious-disease\/coronavirus) lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature [Genetics](https:\/\/www.nature.com\/articles\/s41588-021-00986-w).\n\n\"How we get from infection to smell loss remains unclear,\" said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt [University](https:\/\/www.foxnews.com\/category\/us\/education) in [Nashville, Tenn.](https:\/\/www.foxnews.com\/category\/us\/nashville), who was not part of the [study.](https:\/\/www.mdedge.com\/hematology-oncology\/article\/250852\/covid-19-updates\/study-finds-genetic-factor-covid-smell-and-taste)\n\nResearchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the [United States](https:\/\/www.foxnews.com\/us) and [United Kingdom](https:\/\/www.foxnews.com\/category\/world\/world-regions\/united-kingdom) who took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not.\n\nAmong those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the [study.](https:\/\/www.nature.com\/articles\/s41588-021-00986-w\/tables\/1)\n\n![FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. ](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2021\/09\/1200\/675\/Coronavirus-Ventilator.jpg?ve=1&tl=1)\n\nFILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021.  (AP Photo\/Kyle Green, File)\n\n[**COVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT**](https:\/\/www.foxnews.com\/world\/covid-19-russia-high-infections-omicron-variant)\n\nThe study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of [European](https:\/\/www.foxnews.com\/category\/world\/world-regions\/europe) [ancestry](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\n\nThe research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19.\n\nEven though past [animal](https:\/\/www.foxnews.com\/us\/wild-animals) studies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they \" … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to [smell](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\"\n\nDespite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants[,](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1) and the inability to \"disentangle\" the loss of taste with smell because both were included in a single survey question.\n\n\"Notably, the \\[gene\\] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection,\" the authors [said](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\n\n![FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo\/Jae C. Hong, File) ](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2022\/01\/1200\/675\/Los-Angeles-COVID-patient.jpg?ve=1&tl=1)\n\nFILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo\/Jae C. Hong, File)  (AP)\n\n[**CLICK HERE TO GET THE FOX NEWS APP**](https:\/\/www.foxnews.com\/apps-products)\n\nPrevious research has shown the loss of taste and smell is related to a \"failure to protect the sensory cells of the nose and tongue from viral infection,\" said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the [study](https:\/\/www.mdedge.com\/hematology-oncology\/article\/250852\/covid-19-updates\/study-finds-genetic-factor-covid-smell-and-taste).\n\n\"This study suggests a different direction,\" she noted. \"The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell.\n\n## Related Topics\n- [Coronavirus](https:\/\/www.foxnews.com\/category\/health\/infectious-disease\/coronavirus)\n- [HEALTH](https:\/\/www.foxnews.com\/category\/health)\n- [INFECTIOUS DISEASE](https:\/\/www.foxnews.com\/category\/health\/infectious-disease)\n- [Vaccine](https:\/\/www.foxnews.com\/category\/health\/infectious-disease\/vaccines)\n\n![Fox News Health](https:\/\/static.foxnews.com\/foxnews.com\/content\/uploads\/2022\/11\/NEWSLETTER_HEALTH-532x120.png)\n\n### Fox News Health\nStay up-to-date on the biggest health and wellness news with our weekly recap.\n\nArrives Weekly\n\nBy entering your email and clicking the Subscribe button, you agree to the Fox News [Privacy Policy](https:\/\/www.foxnews.com\/privacy-policy) and [Terms of Use](https:\/\/www.foxnews.com\/terms-of-use), and agree to receive content and promotional communications from Fox News. 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All rights reserved. Quotes displayed in real-time or delayed by at least 15 minutes. Market data provided by [Factset](https:\/\/www.factset.com\/). Powered and implemented by [FactSet Digital Solutions](https:\/\/www.factset.com\/solutions\/business-needs\/digital-solutions). [Legal Statement](https:\/\/www.factset.com\/privacy). Mutual Fund and ETF data provided by [LSEG](https:\/\/lipperalpha.refinitiv.com\/).\n\n[![Close modal](https:\/\/static.foxnews.com\/static\/orion\/styles\/img\/core\/s\/icons\/close.svg)]()\n\n[Continue](https:\/\/www.foxnews.com\/health\/covid-19-sequalae-loss-taste-smell-explained-genetics)\n\n![](https:\/\/pix.pub\/t.png?l=foxnews-pix-fox-news-reach-and-frequency-062d298b-c587-4c31-a1b7-81d0d182403b&t=795049.3256952916)","attrs_readable_markdown":"The mystery of why people infected with [COVID-19](https:\/\/www.foxnews.com\/category\/health\/infectious-disease\/coronavirus) lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature [Genetics](https:\/\/www.nature.com\/articles\/s41588-021-00986-w).\n\n\"How we get from infection to smell loss remains unclear,\" said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt [University](https:\/\/www.foxnews.com\/category\/us\/education) in [Nashville, Tenn.](https:\/\/www.foxnews.com\/category\/us\/nashville), who was not part of the [study.](https:\/\/www.mdedge.com\/hematology-oncology\/article\/250852\/covid-19-updates\/study-finds-genetic-factor-covid-smell-and-taste)\n\nResearchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the [United States](https:\/\/www.foxnews.com\/us) and [United Kingdom](https:\/\/www.foxnews.com\/category\/world\/world-regions\/united-kingdom) who took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not.\n\nAmong those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the [study.](https:\/\/www.nature.com\/articles\/s41588-021-00986-w\/tables\/1)\n\n![FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. ](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2021\/09\/1200\/675\/Coronavirus-Ventilator.jpg?ve=1&tl=1)\n\nFILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021.  (AP Photo\/Kyle Green, File)\n\n[**COVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT**](https:\/\/www.foxnews.com\/world\/covid-19-russia-high-infections-omicron-variant)\n\nThe study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of [European](https:\/\/www.foxnews.com\/category\/world\/world-regions\/europe) [ancestry](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\n\nThe research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19.\n\nEven though past [animal](https:\/\/www.foxnews.com\/us\/wild-animals) studies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they \" … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to [smell](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\"\n\nDespite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants[,](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1) and the inability to \"disentangle\" the loss of taste with smell because both were included in a single survey question.\n\n\"Notably, the \\[gene\\] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection,\" the authors [said](https:\/\/www.nature.com\/articles\/s41588-021-00986-w#Tab1).\n\n![FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo\/Jae C. Hong, File) ](https:\/\/a57.foxnews.com\/static.foxnews.com\/foxnews.com\/content\/uploads\/2022\/01\/1200\/675\/Los-Angeles-COVID-patient.jpg?ve=1&tl=1)\n\nFILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo\/Jae C. Hong, File)  (AP)\n\n[**CLICK HERE TO GET THE FOX NEWS APP**](https:\/\/www.foxnews.com\/apps-products)\n\nPrevious research has shown the loss of taste and smell is related to a \"failure to protect the sensory cells of the nose and tongue from viral infection,\" said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the [study](https:\/\/www.mdedge.com\/hematology-oncology\/article\/250852\/covid-19-updates\/study-finds-genetic-factor-covid-smell-and-taste).\n\n\"This study suggests a different direction,\" she noted. \"The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell.","meta_canonical":null}

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URL	https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics
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Meta Title	COVID-19 lingering loss of taste or smell may be explained by genetics, study finds \| Fox News
Meta Description	The mystery of why people infected with COVID-19 lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature Genetics.
Meta Canonical	null
Boilerpipe Text	The mystery of why people infected with COVID-19 lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature Genetics . "How we get from infection to smell loss remains unclear," said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt University in Nashville, Tenn. , who was not part of the study. Researchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the United States and United Kingdom who took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not. Among those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the study. FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. (AP Photo/Kyle Green, File) COVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT The study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of European ancestry . The research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19. Even though past animal studies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they " … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to smell ." Despite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants , and the inability to "disentangle" the loss of taste with smell because both were included in a single survey question. "Notably, the [gene] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection," the authors said . FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo/Jae C. Hong, File) (AP) CLICK HERE TO GET THE FOX NEWS APP Previous research has shown the loss of taste and smell is related to a "failure to protect the sensory cells of the nose and tongue from viral infection," said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the study . "This study suggests a different direction," she noted. "The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell.
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[![Welcome to Medicaid’s biggest fraud](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/3c9bd547-2a3c-44ab-a20e-f0c10f8d268d/8cabcff5-6b06-4901-95d6-20fd20414ac5/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390940516112) [Welcome to Medicaid’s biggest fraud](https://www.foxnews.com/video/6390940516112) - [![New Bostonian phone booth lets you 'CALL A BOOMER'](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/d35eefed-f46b-4d84-b6ec-16c82ad39a8c/d74a652b-dffb-4f1a-9d91-63639df9e131/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390924766112) [New Bostonian phone booth lets you 'CALL A BOOMER'](https://www.foxnews.com/video/6390924766112) - [![White House advisor calls for food pyramid reform to lower healthcare costs](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/55d750cb-eef9-45f9-8c8f-cc734d6126ba/fbfb258a-f0c6-4b94-92d7-c93bb6e4ea11/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390921039112) [White House advisor calls for food pyramid reform to lower healthcare costs](https://www.foxnews.com/video/6390921039112) - [![Colorectal cancer survivor says symptoms were dismissed for years before diagnosis](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/7ad02810-3c13-4bb2-a913-7e94eea61523/fe32f015-dce8-4655-bb5c-9e74681ba2be/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390882116112) [Colorectal cancer survivor says symptoms were dismissed for years before diagnosis](https://www.foxnews.com/video/6390882116112) - [![NJ teen desperately seeking help to find kidney donor](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/989f4cbb-3fb9-4eb4-af89-df7907ebb35d/50ca65f7-59b1-4ac3-9e0a-e036ec6e3bf3/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390783489112) [NJ teen desperately seeking help to find kidney donor](https://www.foxnews.com/video/6390783489112) - [![President Trump touts plan to lower drug prices for working families](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/7acb8721-dd03-46b1-96a4-bb56842ebfab/d424d9e0-fa39-4030-8a10-e24ad1b805f3/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390749746112) [President Trump touts plan to lower drug prices for working families](https://www.foxnews.com/video/6390749746112) - [![Childhood obesity surges across US, experts point to ultra-processed food](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/e39f1b5d-0d51-4a1a-94ac-4cbdd538cf6a/d92eaef6-178f-4767-b38e-ef0637ad0eb3/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390626105112) [Childhood obesity surges across US, experts point to ultra-processed food](https://www.foxnews.com/video/6390626105112) - [![California firefighter shares tips for living longer amid job hazards](https://a57.foxnews.com/cf-images.us-east-1.prod.boltdns.net/v1/static/694940094001/b0dfe245-bdd2-4c2e-961c-9065e5fc0cd9/3eb1e58c-3ed4-4a95-8836-9169cae1d3ad/1280x720/match/320/180/image.jpg?ve=1&tl=1)](https://www.foxnews.com/video/6390614897112) [California firefighter shares tips for living longer amid job hazards](https://www.foxnews.com/video/6390614897112) Right Arrow [Coronavirus](https://www.foxnews.com/category/health/infectious-disease/coronavirus) # COVID-19 lingering loss of taste or smell may be explained by genetics, study finds ## Research from 23andme found that female respondents were 11% more likely to lose their sense of taste and smell out of almost 70,000 people By [Shiv Sudhakar](https://www.foxnews.com/person/s/shiv-sudhakar) [Fox News](https://www.foxnews.com/) Published [January 21, 2022 4:05pm EST](https://www.foxnews.com/html-sitemap/2022/january/21) - [Facebook](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) - [Twitter](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) - [Threads](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) - [Flipboard](https://share.flipboard.com/bookmarklet/popout?v=2&title=COVID-19%20lingering%20loss%20of%20taste%20or%20smell%20may%20be%20explained%20by%20genetics%2C%20study%20finds%20%7C%20Fox%20News&url=https%3A%2F%2Fwww.foxnews.com%2Fhealth%2Fcovid-19-sequalae-loss-taste-smell-explained-genetics&t=1773958413385&utm_campaign=tools&utm_medium=article-share&utm_source=www.foxnews.com) - [Comments](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) - [Print](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics.print) - [Email](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) - [Add Fox News on Google](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) [close](https://www.foxnews.com/health/covid-19-sequalae-loss-taste-smell-explained-genetics) #### [Va. governor's decision to lift COVID mask mandate will 'confirm that parents matter': Jason Miyares](https://www.foxnews.com/video/6292959021001) Virginia attorney general gives his take on Gov. Glenn Youngkin allowing a mask mandate opt-out on 'America Reports.' The mystery of why people infected with [COVID-19](https://www.foxnews.com/category/health/infectious-disease/coronavirus) lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature [Genetics](https://www.nature.com/articles/s41588-021-00986-w). "How we get from infection to smell loss remains unclear," said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt [University](https://www.foxnews.com/category/us/education) in [Nashville, Tenn.](https://www.foxnews.com/category/us/nashville), who was not part of the [study.](https://www.mdedge.com/hematology-oncology/article/250852/covid-19-updates/study-finds-genetic-factor-covid-smell-and-taste) Researchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the [United States](https://www.foxnews.com/us) and [United Kingdom](https://www.foxnews.com/category/world/world-regions/united-kingdom) who took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not. Among those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the [study.](https://www.nature.com/articles/s41588-021-00986-w/tables/1) ![FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. ](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2021/09/1200/675/Coronavirus-Ventilator.jpg?ve=1&tl=1) FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. (AP Photo/Kyle Green, File) [COVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT](https://www.foxnews.com/world/covid-19-russia-high-infections-omicron-variant) The study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of [European](https://www.foxnews.com/category/world/world-regions/europe) [ancestry](https://www.nature.com/articles/s41588-021-00986-w#Tab1). The research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19. Even though past [animal](https://www.foxnews.com/us/wild-animals) studies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they " … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to [smell](https://www.nature.com/articles/s41588-021-00986-w#Tab1)." Despite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants[,](https://www.nature.com/articles/s41588-021-00986-w#Tab1) and the inability to "disentangle" the loss of taste with smell because both were included in a single survey question. "Notably, the \[gene\] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection," the authors [said](https://www.nature.com/articles/s41588-021-00986-w#Tab1). ![FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo/Jae C. Hong, File) ](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2022/01/1200/675/Los-Angeles-COVID-patient.jpg?ve=1&tl=1) FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo/Jae C. Hong, File) (AP) [CLICK HERE TO GET THE FOX NEWS APP](https://www.foxnews.com/apps-products) Previous research has shown the loss of taste and smell is related to a "failure to protect the sensory cells of the nose and tongue from viral infection," said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the [study](https://www.mdedge.com/hematology-oncology/article/250852/covid-19-updates/study-finds-genetic-factor-covid-smell-and-taste). "This study suggests a different direction," she noted. "The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell. ## Related Topics - [Coronavirus](https://www.foxnews.com/category/health/infectious-disease/coronavirus) - [HEALTH](https://www.foxnews.com/category/health) - [INFECTIOUS DISEASE](https://www.foxnews.com/category/health/infectious-disease) - [Vaccine](https://www.foxnews.com/category/health/infectious-disease/vaccines) ![Fox News Health](https://static.foxnews.com/foxnews.com/content/uploads/2022/11/NEWSLETTER_HEALTH-532x120.png) ### Fox News Health Stay up-to-date on the biggest health and wellness news with our weekly recap. Arrives Weekly By entering your email and clicking the Subscribe button, you agree to the Fox News [Privacy Policy](https://www.foxnews.com/privacy-policy) and [Terms of Use](https://www.foxnews.com/terms-of-use), and agree to receive content and promotional communications from Fox News. 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Readable Markdown	The mystery of why people infected with [COVID-19](https://www.foxnews.com/category/health/infectious-disease/coronavirus) lose their taste or smell may lie in a genetic risk factor, according to a recent study published in Nature [Genetics](https://www.nature.com/articles/s41588-021-00986-w). "How we get from infection to smell loss remains unclear," said Dr. Justin Turner, an associate professor of otolaryngology at Vanderbilt [University](https://www.foxnews.com/category/us/education) in [Nashville, Tenn.](https://www.foxnews.com/category/us/nashville), who was not part of the [study.](https://www.mdedge.com/hematology-oncology/article/250852/covid-19-updates/study-finds-genetic-factor-covid-smell-and-taste) Researchers from 23andMe, a genomics and biotechnology company, analyzed data from 69,841 individuals in the [United States](https://www.foxnews.com/us) and [United Kingdom](https://www.foxnews.com/category/world/world-regions/united-kingdom) who took online surveys after having a positive COVID-19 test, comparing those who reported a loss of taste or smell with those who did not. Among those who tested positive for COVID-19, 68% participants reported a loss of taste or smell, the female respondents were 11% more likely than men to report the symptoms and approximately 73% were ages 26-35, per the [study.](https://www.nature.com/articles/s41588-021-00986-w/tables/1) ![FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. ](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2021/09/1200/675/Coronavirus-Ventilator.jpg?ve=1&tl=1) FILE - In this Aug. 31, 2021, file photo, Jack Kingsley R.N. attends to a COVID-19 patient in the Medical Intensive care unit (MICU) at St. Luke's Boise Medical Center in Boise, Idaho. The summer that was supposed to mark America’s independence from COVID-19 is instead drawing to a close with the U.S. more firmly under the tyranny of the virus, with deaths per day back up to where they were in March 2021. (AP Photo/Kyle Green, File) [COVID-19: RUSSIA HITS ALL-TIME HIGH INFECTIONS, BLAMES OMICRON VARIANT](https://www.foxnews.com/world/covid-19-russia-high-infections-omicron-variant) The study also found the loss of taste or smell was more common among those with a COVID-19 test compared to those who tested negative but reported cold-flu like symptoms, noting those of East Asian or African American ancestry were significantly less likely to report the loss of smell or taste compared to individuals of [European](https://www.foxnews.com/category/world/world-regions/europe) [ancestry](https://www.nature.com/articles/s41588-021-00986-w#Tab1). The research team compared the genetic differences of those who reported a loss of taste or smell with those who didn’t, finding a location near two genes, UGT2A1 and UGT2A2, to be related to the sense of smell that is associated with the loss of taste and smell after being infected with COVID-19. Even though past [animal](https://www.foxnews.com/us/wild-animals) studies showed these genes, which are expressed in the tissue in our nose, are involved in the elimination of ‘odorants’ and previous experimental studies suggest the loss of smell is related to tissue damage along the lining of the nose, the authors concede it’s unclear how the genes are actually involved, only that they " … may play a role in the physiology of infected cells and the resulting functional impairment that contributes to loss of ability to [smell](https://www.nature.com/articles/s41588-021-00986-w#Tab1)." Despite the research being a large scale study, it did have several limitations, including a bias toward European ancestry participants, relying only on self-report surveys without any clinical evaluations of the participants[,](https://www.nature.com/articles/s41588-021-00986-w#Tab1) and the inability to "disentangle" the loss of taste with smell because both were included in a single survey question. "Notably, the \[gene\] variant identified in this study also appears to be associated with general ability to smell, which may suggest that those with heightened smell or taste sensitivity may be more prone to notice a loss of these senses resulting from a SARS-CoV-2 infection," the authors [said](https://www.nature.com/articles/s41588-021-00986-w#Tab1). ![FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo/Jae C. Hong, File) ](https://a57.foxnews.com/static.foxnews.com/foxnews.com/content/uploads/2022/01/1200/675/Los-Angeles-COVID-patient.jpg?ve=1&tl=1) FILE - Registered nurse Emily Yu, left, talks to Paul Altamirano, a 50-year-old COVID-19 patient, at Providence Holy Cross Medical Center in Los Angeles, Dec. 13, 2021. Hospitals across the U.S. are feeling the wrath of the omicron variant and getting thrown into disarray that is different from earlier COVID-19 surges. (AP Photo/Jae C. Hong, File) (AP) [CLICK HERE TO GET THE FOX NEWS APP](https://www.foxnews.com/apps-products) Previous research has shown the loss of taste and smell is related to a "failure to protect the sensory cells of the nose and tongue from viral infection," said Danielle Reed, PhD, associate director of Philadelphia’s Monell Chemical Senses Center. Reed studies the person-to-person differences in the loss of taste and smell as a result of COVID-19, but was not part of the [study](https://www.mdedge.com/hematology-oncology/article/250852/covid-19-updates/study-finds-genetic-factor-covid-smell-and-taste). "This study suggests a different direction," she noted. "The pathways that break down the chemicals that cause taste and smell in the first place might be over or underactive, reducing or distorting the ability to taste and smell.
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