🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 131 (from laksa153)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa131.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html","crawl_time":1774280769,"first_indexed_time":1725904198,"http_code":200,"src_unparsed":"com,drugs!www,\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html s443","src_root_hash":"1816286668162245731","history_drop_reason":null,"meta_title":"COVID-19 MRNA (Pfizer) Vaccine Side Effects: Common, Severe, Long Term","meta_descriptions":["Learn about the side effects of COVID-19 mRNA (Pfizer) vaccine, from common to rare, for consumers and healthcare professionals."],"attrs_boilerpipe_text":"Medically reviewed\nby Drugs.com. Last updated on Sep 15, 2025.\nSerious side effects\nOther side effects\nProfessional info\nFAQ\nApplies to\nCOVID-19 mRNA (Pfizer) vaccine\n:\nintramuscular suspension\n.\nIntramuscular route (suspension)\nAlthough the licensed vaccine (\nComirnaty\n®) is FDA-approved in patients aged 16 or older for 2 doses ,\nPfizer-BioNTech COVID-19 vaccine\nis an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid\norgan transplant\nrecipients or have an equivalent level of immunocompromise.\nPrecautions\nBe sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine.\nFainting\nmay occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting.\nThis vaccine may cause serious allergic reactions, including\nanaphylaxis\n, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a\nfast heartbeat\n, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine.\nThis vaccine may increase your risk of serious heart problems (eg, myocarditis,\npericarditis\n), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness.\nThis vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19.\nDo not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.\nSerious side effects\nAlong with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\nCheck with your doctor or nurse immediately\nif any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine:\nMore common side effects\nchills\ndiarrhea\nfever\nheadache\nirritability\njoint or\nmuscle pain\nswollen, painful, or tender lymph glands in the neck, armpit, or groin\nunusual tiredness or weakness\nLess common side effects\nRare side effects\ndecreased appetite\ngeneral feeling of discomfort or illness\npain in the arms\nrash\nIncidence not known\nanxiety\nblue or pale skin\nchest discomfort or tightness\nchest pain, possible moving to the left arm, neck, or shoulder\ncough\ndifficulty swallowing\ndizziness\nfast heartbeat\nfainting\nlarge, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs\npuffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\ntrouble breathing\nOther side effects\nSome side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually\ndo not need medical attention\n. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.\nCheck with your health care professional if any of the following side effects\ncontinue or are bothersome\nor if you have any questions about them:\nMore common side effects\npain, redness, or swelling at the injection site\nFor healthcare professionals\nApplies to COVID-19 mRNA (Pfizer) vaccine:\nintramuscular suspension\n.\nGeneral adverse events\nThe most commonly reported side effects included injection site pain, fatigue, and headache.\n[\nRef\n]\nCardiovascular\nPostmarketing reports\n: Myocarditis, pericarditis\n[\nRef\n]\nDermatologic\nFrequency not reported\n: Hyperhidrosis, night sweats\nPostmarketing reports\n:\nPruritus\n, rash,\nurticaria\n[\nRef\n]\nGastrointestinal\nVery common\n(10% or more): Diarrhea (up to 11.1%)\nCommon\n(1% to 10%): Vomiting\nFrequency not reported\n: Nausea\n[\nRef\n]\nHematologic\nCommon\n(1% to 10%):\nLymphadenopathy\n[\nRef\n]\nHypersensitivity\nPostmarketing reports\n: Anaphylaxis,\nangioedema\n, other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions\n[\nRef\n]\nLocal\nVery common\n(10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%)\nPostmarketing reports\n: Extremity (arm) pain\n[\nRef\n]\nMetabolic\nFrequency not reported\n: Decreased appetite\n[\nRef\n]\nMusculoskeletal\nVery common\n(10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new\/worsened muscle pain (up to 39.3%),\njoint pain\n(up to 27.5%), new\/worsened joint pain (up to 23.8%)\n[\nRef\n]\nNervous system\nVery common\n(10% or more): Headache (up to 75.5%)\nFrequency not reported\n: Bell's palsy\/facial paralysis,\nlethargy\nPostmarketing reports\n: Dizziness,\nsyncope\n[\nRef\n]\nOther\nVery common\n(10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%)\nFrequency not reported\n: Asthenia, malaise, febrile seizures\n[\nRef\n]\nReferences\n1. (2023) \"Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\"\nPfizer U.S. Pharmaceuticals Group\n2. (2024) \"Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\"\nPfizer U.S. Pharmaceuticals Group\n3. (2025) \"Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\"\nPfizer Inc.\nDoes COVID-19 mRNA (Pfizer) vaccine interact with my other drugs?\nEnter medications to view a detailed interaction report using our\nDrug Interaction Checker\n.\nFrequently asked questions\nCan you become immune to COVID-19?\nCOVID-19 vaccines and variants: What you should know\nFurther information\nCOVID-19 mRNA (Pfizer) vaccine\nside effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\nNote:\nMedication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following\nthis guide\n.\nMedical Disclaimer","attrs_markdown":"[Skip to main content](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#content)\n\n[![Drugs.com - Go to homepage](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo.svg)](https:\/\/www.drugs.com\/)\n\n[Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n\nSite navigation\n\n- [**Upgrade to a Plus Plan** Remove ads and unlock more features.](https:\/\/www.drugs.com\/account\/plan\/?launch=ddc-tier-1)\n- [Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n- [Drugs A-Z](https:\/\/www.drugs.com\/drug_information.html)\n- [Pill Identifier](https:\/\/www.drugs.com\/pill_identification.html)\n- [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html)\n- [Compare Drugs](https:\/\/www.drugs.com\/compare\/)\n- [News](https:\/\/www.drugs.com\/news.html)\n- [Pro Edition](https:\/\/www.drugs.com\/professionals.html)\n- [More Resources](https:\/\/www.drugs.com\/sitemap.html)\n- [Help & Support](https:\/\/www.drugs.com\/support\/)\n\nClose\n\n1. [Home](https:\/\/www.drugs.com\/)\n2. [COVID-19 mRNA (Pfizer) vaccine](https:\/\/www.drugs.com\/cons\/sars-cov-2-covid-19-vaccine-mrna-pfizer.html)\n3. Side Effects\n\nPrint\n\nSave\n# COVID-19 MRNA (Pfizer) Vaccine Side Effects\n[Medically reviewed](https:\/\/www.drugs.com\/support\/editorial-policy.html#editorial-staff) by Drugs.com. Last updated on Sep 15, 2025.\n\n- [Serious side effects](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#serious-side-effects)\n- [Other side effects](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#other-side-effects)\n- [Professional info](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#professional-info)\n- [FAQ](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#faq)\n\nApplies to [COVID-19 mRNA (Pfizer) vaccine](https:\/\/www.drugs.com\/cons\/sars-cov-2-covid-19-vaccine-mrna-pfizer.html): **intramuscular suspension**.\n\n## **Important warnings** This medicine can cause some serious health issues\nIntramuscular route (suspension)\n\nAlthough the licensed vaccine ([Comirnaty](https:\/\/www.drugs.com\/comirnaty.html)®) is FDA-approved in patients aged 16 or older for 2 doses , [Pfizer-BioNTech COVID-19 vaccine](https:\/\/www.drugs.com\/pfizer-biontech-covid-19-vaccine.html) is an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid [organ transplant](https:\/\/www.drugs.com\/cg\/liver-transplant-discharge-care.html) recipients or have an equivalent level of immunocompromise.\n## Precautions\nBe sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine.\n\n[Fainting](https:\/\/www.drugs.com\/cg\/syncope.html) may occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting.\n\nThis vaccine may cause serious allergic reactions, including [anaphylaxis](https:\/\/www.drugs.com\/cg\/anaphylaxis.html), which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a [fast heartbeat](https:\/\/www.drugs.com\/cg\/tachycardia.html), trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine.\n\nThis vaccine may increase your risk of serious heart problems (eg, myocarditis, [pericarditis](https:\/\/www.drugs.com\/health-guide\/pericarditis.html)), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness.\n\nThis vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19.\n\nDo not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter \\[OTC\\]) medicines and herbal or vitamin supplements.\n\n## Serious side effects\nAlong with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\n\n*Check with your doctor or nurse immediately* if any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine:\n\n### More common side effects\n- chills\n- [diarrhea](https:\/\/www.drugs.com\/health-guide\/diarrhea.html)\n- fever\n- [headache](https:\/\/www.drugs.com\/cg\/tension-headache.html)\n- irritability\n- joint or [muscle pain](https:\/\/www.drugs.com\/cg\/ankle-sprain.html)\n- swollen, painful, or tender lymph glands in the neck, armpit, or groin\n- unusual tiredness or weakness\n\n### Less common side effects\n- nausea\n- [vomiting](https:\/\/www.drugs.com\/health-guide\/nausea.html)\n\n### Rare side effects\n- decreased appetite\n- general feeling of discomfort or illness\n- pain in the arms\n- rash\n\n### Incidence not known\n- anxiety\n- blue or pale skin\n- chest discomfort or tightness\n- chest pain, possible moving to the left arm, neck, or shoulder\n- cough\n- [difficulty swallowing](https:\/\/www.drugs.com\/cg\/dysphagia.html)\n- dizziness\n- fast heartbeat\n- fainting\n- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs\n- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\n- trouble breathing\n## Other side effects\nSome side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually **do not need medical attention**. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.\n\nCheck with your health care professional if any of the following side effects **continue or are bothersome** or if you have any questions about them:\n\n### More common side effects\n- pain, redness, or swelling at the injection site\n## See also:\n### [Abrysvo](https:\/\/www.drugs.com\/abrysvo.html)\nAbrysvo is a vaccine used to prevent respiratory syncytial virus (RSV) lower respiratory tract ...\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=4475&brand_name_id=20398&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/abrysvo.html)\n\n### [ACAM2000](https:\/\/www.drugs.com\/acam2000.html)\nACAM2000 vaccine may be used to prevent smallpox and mpox disease in people of any age at high risk ...\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=4089&brand_name_id=20846&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/acam2000.html)\n\nFeatured\n\n### [Ubrelvy](https:\/\/www.drugs.com\/ubrelvy.html)\nUbrelvy (ubrogepant) tablets are used for the acute treatment of migraine. Includes Ubrelvy side ...\n\n**Reviews & ratings**\n\n6\\.7 \/ 10\n\n[306 Reviews](https:\/\/www.drugs.com\/comments\/ubrogepant\/ubrelvy.html)\n\n[View more](https:\/\/www.drugs.com\/ubrelvy.html)\n\n### [Afluria](https:\/\/www.drugs.com\/afluria.html)\nAfluria is a vaccine used to prevent infection caused by influenza virus. Learn about side effects ...\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=1337&brand_name_id=12150&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/afluria.html)\n\n### [Afluria Preservative-Free Pediatric Quadrivalent](https:\/\/www.drugs.com\/mtm\/afluria-pf-pediatric-quadrivalent-2021-2022-injection.html)\nAfluria Preservative-Free Pediatric Quadrivalent is used for influenza prophylaxis\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=1337&brand_name_id=19551&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/mtm\/afluria-pf-pediatric-quadrivalent-2021-2022-injection.html)\n\n### [Afluria Preservative-Free Quadrivalent](https:\/\/www.drugs.com\/mtm\/afluria-pf-quadrivalent-2021-2022-injection.html)\nAfluria Preservative-Free Quadrivalent is used for influenza prophylaxis\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=1337&brand_name_id=19552&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/mtm\/afluria-pf-quadrivalent-2021-2022-injection.html)\n\n### [Afluria Quadrivalent](https:\/\/www.drugs.com\/mtm\/afluria-quadrivalent-2021-2022-injection.html)\nAfluria Quadrivalent is used for influenza prophylaxis\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=1337&brand_name_id=18164&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/mtm\/afluria-quadrivalent-2021-2022-injection.html)\n\n### [Arexvy](https:\/\/www.drugs.com\/arexvy.html)\nArexvy is a vaccine used to prevent respiratory syncytial virus (RSV) lower respiratory tract ...\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=4531&brand_name_id=20556&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/arexvy.html)\n\n### [Audenz](https:\/\/www.drugs.com\/cons\/audenz.html)\nAudenz is used for influenza prophylaxis\n\n**Reviews & ratings**\n\n[Add a review](https:\/\/www.drugs.com\/members_comments_add\/?ddc_id=2755&brand_name_id=19386&condition_id=0)\n\n[View more](https:\/\/www.drugs.com\/cons\/audenz.html)\n\n### [Comirnaty](https:\/\/www.drugs.com\/comirnaty.html)\nComirnaty (made by Pfizer-BioNTech) is an mRNA COVID-19 vaccine that can be given to adults aged 65 ...\n\n**Reviews & ratings**\n\n[1 Review](https:\/\/www.drugs.com\/comments\/covid-19-mrna-pfizer-vaccine\/comirnaty.html)\n\n[View more](https:\/\/www.drugs.com\/comirnaty.html)\n\n[Managing side effects](https:\/\/www.drugs.com\/article\/drug-side-effects.html) (general information)\n\n## For healthcare professionals\nApplies to COVID-19 mRNA (Pfizer) vaccine: **intramuscular suspension**.\n\n### General adverse events\nThe most commonly reported side effects included injection site pain, fatigue, and headache.\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n\n### Cardiovascular\n- **Postmarketing reports**: Myocarditis, pericarditis\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Dermatologic\n- **Frequency not reported**: Hyperhidrosis, night sweats\n- **Postmarketing reports**: [Pruritus](https:\/\/www.drugs.com\/cg\/itchy-skin.html), rash, [urticaria](https:\/\/www.drugs.com\/cg\/urticaria.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Gastrointestinal\n- **Very common** (10% or more): Diarrhea (up to 11.1%)\n- **Common** (1% to 10%): Vomiting\n- **Frequency not reported**: Nausea\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Hematologic\n- **Common** (1% to 10%): [Lymphadenopathy](https:\/\/www.drugs.com\/cg\/lymphadenopathy.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Hypersensitivity\n- **Postmarketing reports**: Anaphylaxis, [angioedema](https:\/\/www.drugs.com\/cg\/angioedema.html), other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Local\n- **Very common** (10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%)\n- **Postmarketing reports**: Extremity (arm) pain\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Metabolic\n- **Frequency not reported**: Decreased appetite\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Musculoskeletal\n- **Very common** (10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new\/worsened muscle pain (up to 39.3%), [joint pain](https:\/\/www.drugs.com\/cg\/osteoarthritis.html) (up to 27.5%), new\/worsened joint pain (up to 23.8%)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Nervous system\n- **Very common** (10% or more): Headache (up to 75.5%)\n- **Frequency not reported**: Bell's palsy\/facial paralysis, [lethargy](https:\/\/www.drugs.com\/cg\/fatigue.html)\n- **Postmarketing reports**: Dizziness, [syncope](https:\/\/www.drugs.com\/cg\/syncope.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Other\n- **Very common** (10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%)\n- **Frequency not reported**: Asthenia, malaise, febrile seizures\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n\n#### References\n1\\. (2023) \"Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer U.S. Pharmaceuticals Group*\n\n2\\. (2024) \"Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer U.S. Pharmaceuticals Group*\n\n3\\. (2025) \"Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer Inc.*\n\n### Does COVID-19 mRNA (Pfizer) vaccine interact with my other drugs?\nEnter medications to view a detailed interaction report using our [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html).\n## Frequently asked questions\n- [Can you become immune to COVID-19?](https:\/\/www.drugs.com\/medical-answers\/you-immune-covid-19-3537185\/)\n- [COVID-19 vaccines and variants: What you should know](https:\/\/www.drugs.com\/medical-answers\/coronavirus-mutate-3535321\/)\n\n## More about COVID-19 mRNA (Pfizer) vaccine\n- [Check interactions](https:\/\/www.drugs.com\/drug-interactions\/covid-19-mrna-pfizer-vaccine.html)\n- [Compare alternatives](https:\/\/www.drugs.com\/compare\/covid-19-mrna-pfizer-vaccine)\n- [Reviews (18)](https:\/\/www.drugs.com\/comments\/covid-19-mrna-pfizer-vaccine\/for-covid-19.html)\n- [Latest FDA alerts (1)](https:\/\/www.drugs.com\/fda-alerts\/4638-0.html)\n- [Dosage information](https:\/\/www.drugs.com\/dosage\/covid-19-mrna-pfizer-vaccine.html)\n- [During pregnancy](https:\/\/www.drugs.com\/pregnancy\/covid-19-mrna-pfizer-vaccine.html)\n- [Drug class: viral vaccines](https:\/\/www.drugs.com\/drug-class\/viral-vaccines.html)\n### Patient resources\n- [Sars-cov-2 (covid-19) vaccine, mrna (pfizer) advanced reading](https:\/\/www.drugs.com\/cons\/sars-cov-2-covid-19-vaccine-mrna-pfizer.html)\n#### Other brands\n[Comirnaty](https:\/\/www.drugs.com\/comirnaty.html), [Pfizer-BioNTech COVID-19 Vaccine](https:\/\/www.drugs.com\/pfizer-biontech-covid-19-vaccine.html)\n\n### Professional resources\n- [COVID-19 Vaccine, mRNA (Pfizer-BioNTech) (2025-2026 Formula) monograph](https:\/\/www.drugs.com\/monograph\/covid-19-vaccine-mrna-pfizer-biontech-2025-2026-formula.html)\n- [Covid-19 Vaccine Pfizer (FDA)](https:\/\/www.drugs.com\/pro\/covid-19-vaccine-pfizer.html)\n- [Covid-19 Vaccine Pfizer, Bivalent (FDA)](https:\/\/www.drugs.com\/pro\/covid-19-vaccine-pfizer-bivalent.html)\n- [Covid-19 Vaccine Pfizer, Monovalent, 6 mo-4 yr (FDA)](https:\/\/www.drugs.com\/pro\/covid-19-vaccine-pfizer-monovalent-6-mo-4-yr.html)\n- [Covid-19 Vaccine Pfizer, Monovalent,5 yr to 11 yr (FDA)](https:\/\/www.drugs.com\/pro\/covid-19-vaccine-pfizer-monovalent-5-yr-to-11-yr.html)\n- [Pfizer-BioNTech Vaccine (FDA)](https:\/\/www.drugs.com\/pro\/pfizer-biontech-vaccine.html)\n#### Other brands\n[Comirnaty](https:\/\/www.drugs.com\/pro\/comirnaty.html)\n\n### Related treatment guides\n- [COVID-19](https:\/\/www.drugs.com\/condition\/covid-19.html)\n## Further information\n**COVID-19 mRNA (Pfizer) vaccine** side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n**Note:** Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following [this guide](https:\/\/www.drugs.com\/fda-consumer\/your-guide-to-reporting-problems-to-fda-71.html).\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)\n\n**Drug Status**\n\n**Availability** Prescription only Rx\n\n[**Pregnancy & Lactation**](https:\/\/www.drugs.com\/pregnancy\/covid-19-mrna-pfizer-vaccine.html)  Risk data available\n\n**CSA Schedule\\*** Not a controlled drug N\/A\n\nLoading...\n\nUser Reviews & Ratings\n\n7\\.2 \/ 10\n\n[18 Reviews](https:\/\/www.drugs.com\/comments\/covid-19-mrna-pfizer-vaccine\/)\n\n**Drugs.com Mobile App**\n\nAccess drug & treatment information, identify pills, check interactions and set up personal medication records.\n\n[Download the Medication Guide app on iTunes ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/apple-store.png)](https:\/\/apps.apple.com\/us\/app\/drugs-com-medication-guide\/id599471042?platform=iphone)   [Download the Medication Guide app on the Google Play store ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/google-play.png)](https:\/\/play.google.com\/store\/apps\/details?id=com.drugscom.app)\n\n![Drugs.com mobile app](https:\/\/www.drugs.com\/img\/v-20250709\/apps\/promo-uberapp.png)\n\n[Drugs.com ![](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo-mark.svg)](https:\/\/www.drugs.com\/)\n\n**About**\n\n- [About Drugs.com](https:\/\/www.drugs.com\/support\/about.html)\n- [Advertising policy](https:\/\/www.drugs.com\/support\/advertising.html)\n- [Attribution & citations](https:\/\/www.drugs.com\/support\/citations.html)\n- [Drugs.com Podcast](https:\/\/podcasts.drugs.com\/)\n\n**Terms & privacy**\n\n- [Terms of use](https:\/\/www.drugs.com\/support\/terms.html)\n- [Editorial policy](https:\/\/www.drugs.com\/support\/editorial-policy.html)\n- [Privacy policy](https:\/\/www.drugs.com\/support\/privacy.html)\n- [Privacy settings](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html)\n\n**Support**\n\n- [Help center](https:\/\/www.drugs.com\/support\/)\n- [Sitemap](https:\/\/www.drugs.com\/sitemap.html)\n- [Contact us](https:\/\/www.drugs.com\/support\/contact.html)\n- [Accessibility](https:\/\/www.drugs.com\/support\/accessibility.html)\n\n- [Subscribe to Drugs.com newsletters](https:\/\/www.drugs.com\/newsletters\/)\n- [Follow Drugs.com on Facebook](https:\/\/www.facebook.com\/Drugscom)\n- [Follow Drugs.com on X (Twitter)](https:\/\/x.com\/drugscom)\n- [Follow Drugs.com on Instagram](https:\/\/www.instagram.com\/drugs.com_official\/)\n- [Follow Drugs.com on YouTube](https:\/\/www.youtube.com\/user\/drugscom)\n- [Follow Drugs.com on Pinterest](https:\/\/www.pinterest.com\/drugscom\/)\n\n[Subscribe to our newsletter](https:\/\/www.drugs.com\/newsletters\/) for the latest medication news, new drug approvals and FDA alerts.\n\n**Drugs.com** provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Mar 4, 2026), Cerner Multum™ (updated Mar 22, 2026), ASHP (updated Mar 10, 2026) and others.\n\n[![Certified by TRUSTe](https:\/\/privacy-policy.truste.com\/privacy-seal\/seal?rid=d18cba4a-afc4-4863-af81-8262bb120271)](https:\/\/privacy.truste.com\/privacy-seal\/validation?rid=d18cba4a-afc4-4863-af81-8262bb120271)  ![Verified by TAG](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/tag-verified.png)  [![This website is certified by AACI. Click to verify.](https:\/\/www.drugs.com\/img\/v-20251028\/logo\/vendor\/trust-mark-logo.png)](https:\/\/aacihealthcare.com\/certificates\/c173-2022-trust-us\/)   [![AdChoices - Ad privacy information](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/adchoices-logomark.png)](https:\/\/www.drugs.com\/support\/privacy\/advertising.html)\n\nCopyright © 2000-2026 Drugs.com. All rights reserved.","attrs_readable_markdown":"[Medically reviewed](https:\/\/www.drugs.com\/support\/editorial-policy.html#editorial-staff) by Drugs.com. Last updated on Sep 15, 2025.\n\n- [Serious side effects](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#serious-side-effects)\n- [Other side effects](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#other-side-effects)\n- [Professional info](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#professional-info)\n- [FAQ](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#faq)\n\nApplies to [COVID-19 mRNA (Pfizer) vaccine](https:\/\/www.drugs.com\/cons\/sars-cov-2-covid-19-vaccine-mrna-pfizer.html): **intramuscular suspension**.\n\nIntramuscular route (suspension)\n\nAlthough the licensed vaccine ([Comirnaty](https:\/\/www.drugs.com\/comirnaty.html)®) is FDA-approved in patients aged 16 or older for 2 doses , [Pfizer-BioNTech COVID-19 vaccine](https:\/\/www.drugs.com\/pfizer-biontech-covid-19-vaccine.html) is an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid [organ transplant](https:\/\/www.drugs.com\/cg\/liver-transplant-discharge-care.html) recipients or have an equivalent level of immunocompromise.\n## Precautions\nBe sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine.\n\n[Fainting](https:\/\/www.drugs.com\/cg\/syncope.html) may occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting.\n\nThis vaccine may cause serious allergic reactions, including [anaphylaxis](https:\/\/www.drugs.com\/cg\/anaphylaxis.html), which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a [fast heartbeat](https:\/\/www.drugs.com\/cg\/tachycardia.html), trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine.\n\nThis vaccine may increase your risk of serious heart problems (eg, myocarditis, [pericarditis](https:\/\/www.drugs.com\/health-guide\/pericarditis.html)), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness.\n\nThis vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19.\n\nDo not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter \\[OTC\\]) medicines and herbal or vitamin supplements.\n\n## Serious side effects\nAlong with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.\n\n*Check with your doctor or nurse immediately* if any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine:\n\n### More common side effects\n- chills\n- [diarrhea](https:\/\/www.drugs.com\/health-guide\/diarrhea.html)\n- fever\n- [headache](https:\/\/www.drugs.com\/cg\/tension-headache.html)\n- irritability\n- joint or [muscle pain](https:\/\/www.drugs.com\/cg\/ankle-sprain.html)\n- swollen, painful, or tender lymph glands in the neck, armpit, or groin\n- unusual tiredness or weakness\n### Less common side effects\n### Rare side effects\n- decreased appetite\n- general feeling of discomfort or illness\n- pain in the arms\n- rash\n\n### Incidence not known\n- anxiety\n- blue or pale skin\n- chest discomfort or tightness\n- chest pain, possible moving to the left arm, neck, or shoulder\n- cough\n- [difficulty swallowing](https:\/\/www.drugs.com\/cg\/dysphagia.html)\n- dizziness\n- fast heartbeat\n- fainting\n- large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs\n- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue\n- trouble breathing\n## Other side effects\nSome side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually **do not need medical attention**. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.\n\nCheck with your health care professional if any of the following side effects **continue or are bothersome** or if you have any questions about them:\n\n### More common side effects\n- pain, redness, or swelling at the injection site\n## For healthcare professionals\nApplies to COVID-19 mRNA (Pfizer) vaccine: **intramuscular suspension**.\n\n### General adverse events\nThe most commonly reported side effects included injection site pain, fatigue, and headache.\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n\n### Cardiovascular\n- **Postmarketing reports**: Myocarditis, pericarditis\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Dermatologic\n- **Frequency not reported**: Hyperhidrosis, night sweats\n- **Postmarketing reports**: [Pruritus](https:\/\/www.drugs.com\/cg\/itchy-skin.html), rash, [urticaria](https:\/\/www.drugs.com\/cg\/urticaria.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Gastrointestinal\n- **Very common** (10% or more): Diarrhea (up to 11.1%)\n- **Common** (1% to 10%): Vomiting\n- **Frequency not reported**: Nausea\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Hematologic\n- **Common** (1% to 10%): [Lymphadenopathy](https:\/\/www.drugs.com\/cg\/lymphadenopathy.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Hypersensitivity\n- **Postmarketing reports**: Anaphylaxis, [angioedema](https:\/\/www.drugs.com\/cg\/angioedema.html), other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Local\n- **Very common** (10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%)\n- **Postmarketing reports**: Extremity (arm) pain\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Metabolic\n- **Frequency not reported**: Decreased appetite\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Musculoskeletal\n- **Very common** (10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new\/worsened muscle pain (up to 39.3%), [joint pain](https:\/\/www.drugs.com\/cg\/osteoarthritis.html) (up to 27.5%), new\/worsened joint pain (up to 23.8%)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Nervous system\n- **Very common** (10% or more): Headache (up to 75.5%)\n- **Frequency not reported**: Bell's palsy\/facial paralysis, [lethargy](https:\/\/www.drugs.com\/cg\/fatigue.html)\n- **Postmarketing reports**: Dizziness, [syncope](https:\/\/www.drugs.com\/cg\/syncope.html)\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n### Other\n- **Very common** (10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%)\n- **Frequency not reported**: Asthenia, malaise, febrile seizures\\[[Ref](https:\/\/www.drugs.com\/sfx\/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\\]\n\n#### References\n1\\. (2023) \"Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer U.S. Pharmaceuticals Group*\n\n2\\. (2024) \"Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer U.S. Pharmaceuticals Group*\n\n3\\. (2025) \"Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309)).\" *Pfizer Inc.*\n\n### Does COVID-19 mRNA (Pfizer) vaccine interact with my other drugs?\nEnter medications to view a detailed interaction report using our [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html).\n## Frequently asked questions\n- [Can you become immune to COVID-19?](https:\/\/www.drugs.com\/medical-answers\/you-immune-covid-19-3537185\/)\n- [COVID-19 vaccines and variants: What you should know](https:\/\/www.drugs.com\/medical-answers\/coronavirus-mutate-3535321\/)\n## Further information\n**COVID-19 mRNA (Pfizer) vaccine** side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n**Note:** Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following [this guide](https:\/\/www.drugs.com\/fda-consumer\/your-guide-to-reporting-problems-to-fda-71.html).\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)","meta_canonical":null}

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Meta Title	COVID-19 MRNA (Pfizer) Vaccine Side Effects: Common, Severe, Long Term
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Boilerpipe Text	Medically reviewed by Drugs.com. Last updated on Sep 15, 2025. Serious side effects Other side effects Professional info FAQ Applies to COVID-19 mRNA (Pfizer) vaccine : intramuscular suspension . Intramuscular route (suspension) Although the licensed vaccine ( Comirnaty ®) is FDA-approved in patients aged 16 or older for 2 doses , Pfizer-BioNTech COVID-19 vaccine is an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid organ transplant recipients or have an equivalent level of immunocompromise. Precautions Be sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine. Fainting may occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting. This vaccine may cause serious allergic reactions, including anaphylaxis , which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a fast heartbeat , trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine. This vaccine may increase your risk of serious heart problems (eg, myocarditis, pericarditis ), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness. This vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Serious side effects Along with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine: More common side effects chills diarrhea fever headache irritability joint or muscle pain swollen, painful, or tender lymph glands in the neck, armpit, or groin unusual tiredness or weakness Less common side effects Rare side effects decreased appetite general feeling of discomfort or illness pain in the arms rash Incidence not known anxiety blue or pale skin chest discomfort or tightness chest pain, possible moving to the left arm, neck, or shoulder cough difficulty swallowing dizziness fast heartbeat fainting large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue trouble breathing Other side effects Some side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually do not need medical attention . These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common side effects pain, redness, or swelling at the injection site For healthcare professionals Applies to COVID-19 mRNA (Pfizer) vaccine: intramuscular suspension . General adverse events The most commonly reported side effects included injection site pain, fatigue, and headache. [ Ref ] Cardiovascular Postmarketing reports : Myocarditis, pericarditis [ Ref ] Dermatologic Frequency not reported : Hyperhidrosis, night sweats Postmarketing reports : Pruritus , rash, urticaria [ Ref ] Gastrointestinal Very common (10% or more): Diarrhea (up to 11.1%) Common (1% to 10%): Vomiting Frequency not reported : Nausea [ Ref ] Hematologic Common (1% to 10%): Lymphadenopathy [ Ref ] Hypersensitivity Postmarketing reports : Anaphylaxis, angioedema , other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions [ Ref ] Local Very common (10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%) Postmarketing reports : Extremity (arm) pain [ Ref ] Metabolic Frequency not reported : Decreased appetite [ Ref ] Musculoskeletal Very common (10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new/worsened muscle pain (up to 39.3%), joint pain (up to 27.5%), new/worsened joint pain (up to 23.8%) [ Ref ] Nervous system Very common (10% or more): Headache (up to 75.5%) Frequency not reported : Bell's palsy/facial paralysis, lethargy Postmarketing reports : Dizziness, syncope [ Ref ] Other Very common (10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%) Frequency not reported : Asthenia, malaise, febrile seizures [ Ref ] References 1. (2023) "Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 2. (2024) "Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 3. (2025) "Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer Inc. Does COVID-19 mRNA (Pfizer) vaccine interact with my other drugs? Enter medications to view a detailed interaction report using our Drug Interaction Checker . Frequently asked questions Can you become immune to COVID-19? COVID-19 vaccines and variants: What you should know Further information COVID-19 mRNA (Pfizer) vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide . Medical Disclaimer
Markdown	[Skip to main content](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#content) [![Drugs.com - Go to homepage](https://www.drugs.com/img/logo/drugscom-logo.svg)](https://www.drugs.com/) [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) Site navigation - [Upgrade to a Plus Plan Remove ads and unlock more features.](https://www.drugs.com/account/plan/?launch=ddc-tier-1) - [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) - [Drugs A-Z](https://www.drugs.com/drug_information.html) - [Pill Identifier](https://www.drugs.com/pill_identification.html) - [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html) - [Compare Drugs](https://www.drugs.com/compare/) - [News](https://www.drugs.com/news.html) - [Pro Edition](https://www.drugs.com/professionals.html) - [More Resources](https://www.drugs.com/sitemap.html) - [Help & Support](https://www.drugs.com/support/) Close 1. [Home](https://www.drugs.com/) 2. [COVID-19 mRNA (Pfizer) vaccine](https://www.drugs.com/cons/sars-cov-2-covid-19-vaccine-mrna-pfizer.html) 3. Side Effects Print Save # COVID-19 MRNA (Pfizer) Vaccine Side Effects [Medically reviewed](https://www.drugs.com/support/editorial-policy.html#editorial-staff) by Drugs.com. Last updated on Sep 15, 2025. - [Serious side effects](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#serious-side-effects) - [Other side effects](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#other-side-effects) - [Professional info](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#professional-info) - [FAQ](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#faq) Applies to [COVID-19 mRNA (Pfizer) vaccine](https://www.drugs.com/cons/sars-cov-2-covid-19-vaccine-mrna-pfizer.html): intramuscular suspension. ## Important warnings This medicine can cause some serious health issues Intramuscular route (suspension) Although the licensed vaccine ([Comirnaty](https://www.drugs.com/comirnaty.html)®) is FDA-approved in patients aged 16 or older for 2 doses , [Pfizer-BioNTech COVID-19 vaccine](https://www.drugs.com/pfizer-biontech-covid-19-vaccine.html) is an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid [organ transplant](https://www.drugs.com/cg/liver-transplant-discharge-care.html) recipients or have an equivalent level of immunocompromise. ## Precautions Be sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine. [Fainting](https://www.drugs.com/cg/syncope.html) may occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting. This vaccine may cause serious allergic reactions, including [anaphylaxis](https://www.drugs.com/cg/anaphylaxis.html), which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a [fast heartbeat](https://www.drugs.com/cg/tachycardia.html), trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine. This vaccine may increase your risk of serious heart problems (eg, myocarditis, [pericarditis](https://www.drugs.com/health-guide/pericarditis.html)), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness. This vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter \[OTC\]) medicines and herbal or vitamin supplements. ## Serious side effects Along with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine: ### More common side effects - chills - [diarrhea](https://www.drugs.com/health-guide/diarrhea.html) - fever - [headache](https://www.drugs.com/cg/tension-headache.html) - irritability - joint or [muscle pain](https://www.drugs.com/cg/ankle-sprain.html) - swollen, painful, or tender lymph glands in the neck, armpit, or groin - unusual tiredness or weakness ### Less common side effects - nausea - [vomiting](https://www.drugs.com/health-guide/nausea.html) ### Rare side effects - decreased appetite - general feeling of discomfort or illness - pain in the arms - rash ### Incidence not known - anxiety - blue or pale skin - chest discomfort or tightness - chest pain, possible moving to the left arm, neck, or shoulder - cough - [difficulty swallowing](https://www.drugs.com/cg/dysphagia.html) - dizziness - fast heartbeat - fainting - large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs - puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue - trouble breathing ## Other side effects Some side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: ### More common side effects - pain, redness, or swelling at the injection site ## See also: ### [Abrysvo](https://www.drugs.com/abrysvo.html) Abrysvo is a vaccine used to prevent respiratory syncytial virus (RSV) lower respiratory tract ... Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=4475&brand_name_id=20398&condition_id=0) [View more](https://www.drugs.com/abrysvo.html) ### [ACAM2000](https://www.drugs.com/acam2000.html) ACAM2000 vaccine may be used to prevent smallpox and mpox disease in people of any age at high risk ... Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=4089&brand_name_id=20846&condition_id=0) [View more](https://www.drugs.com/acam2000.html) Featured ### [Ubrelvy](https://www.drugs.com/ubrelvy.html) Ubrelvy (ubrogepant) tablets are used for the acute treatment of migraine. Includes Ubrelvy side ... Reviews & ratings 6\.7 / 10 [306 Reviews](https://www.drugs.com/comments/ubrogepant/ubrelvy.html) [View more](https://www.drugs.com/ubrelvy.html) ### [Afluria](https://www.drugs.com/afluria.html) Afluria is a vaccine used to prevent infection caused by influenza virus. Learn about side effects ... Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=1337&brand_name_id=12150&condition_id=0) [View more](https://www.drugs.com/afluria.html) ### [Afluria Preservative-Free Pediatric Quadrivalent](https://www.drugs.com/mtm/afluria-pf-pediatric-quadrivalent-2021-2022-injection.html) Afluria Preservative-Free Pediatric Quadrivalent is used for influenza prophylaxis Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=1337&brand_name_id=19551&condition_id=0) [View more](https://www.drugs.com/mtm/afluria-pf-pediatric-quadrivalent-2021-2022-injection.html) ### [Afluria Preservative-Free Quadrivalent](https://www.drugs.com/mtm/afluria-pf-quadrivalent-2021-2022-injection.html) Afluria Preservative-Free Quadrivalent is used for influenza prophylaxis Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=1337&brand_name_id=19552&condition_id=0) [View more](https://www.drugs.com/mtm/afluria-pf-quadrivalent-2021-2022-injection.html) ### [Afluria Quadrivalent](https://www.drugs.com/mtm/afluria-quadrivalent-2021-2022-injection.html) Afluria Quadrivalent is used for influenza prophylaxis Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=1337&brand_name_id=18164&condition_id=0) [View more](https://www.drugs.com/mtm/afluria-quadrivalent-2021-2022-injection.html) ### [Arexvy](https://www.drugs.com/arexvy.html) Arexvy is a vaccine used to prevent respiratory syncytial virus (RSV) lower respiratory tract ... Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=4531&brand_name_id=20556&condition_id=0) [View more](https://www.drugs.com/arexvy.html) ### [Audenz](https://www.drugs.com/cons/audenz.html) Audenz is used for influenza prophylaxis Reviews & ratings [Add a review](https://www.drugs.com/members_comments_add/?ddc_id=2755&brand_name_id=19386&condition_id=0) [View more](https://www.drugs.com/cons/audenz.html) ### [Comirnaty](https://www.drugs.com/comirnaty.html) Comirnaty (made by Pfizer-BioNTech) is an mRNA COVID-19 vaccine that can be given to adults aged 65 ... Reviews & ratings [1 Review](https://www.drugs.com/comments/covid-19-mrna-pfizer-vaccine/comirnaty.html) [View more](https://www.drugs.com/comirnaty.html) [Managing side effects](https://www.drugs.com/article/drug-side-effects.html) (general information) ## For healthcare professionals Applies to COVID-19 mRNA (Pfizer) vaccine: intramuscular suspension. ### General adverse events The most commonly reported side effects included injection site pain, fatigue, and headache.\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Cardiovascular - Postmarketing reports: Myocarditis, pericarditis\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Dermatologic - Frequency not reported: Hyperhidrosis, night sweats - Postmarketing reports: [Pruritus](https://www.drugs.com/cg/itchy-skin.html), rash, [urticaria](https://www.drugs.com/cg/urticaria.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Gastrointestinal - Very common (10% or more): Diarrhea (up to 11.1%) - Common (1% to 10%): Vomiting - Frequency not reported: Nausea\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Hematologic - Common (1% to 10%): [Lymphadenopathy](https://www.drugs.com/cg/lymphadenopathy.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Hypersensitivity - Postmarketing reports: Anaphylaxis, [angioedema](https://www.drugs.com/cg/angioedema.html), other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Local - Very common (10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%) - Postmarketing reports: Extremity (arm) pain\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Metabolic - Frequency not reported: Decreased appetite\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Musculoskeletal - Very common (10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new/worsened muscle pain (up to 39.3%), [joint pain](https://www.drugs.com/cg/osteoarthritis.html) (up to 27.5%), new/worsened joint pain (up to 23.8%)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Nervous system - Very common (10% or more): Headache (up to 75.5%) - Frequency not reported: Bell's palsy/facial paralysis, [lethargy](https://www.drugs.com/cg/fatigue.html) - Postmarketing reports: Dizziness, [syncope](https://www.drugs.com/cg/syncope.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Other - Very common (10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%) - Frequency not reported: Asthenia, malaise, febrile seizures\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] #### References 1\. (2023) "Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 2\. (2024) "Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 3\. (2025) "Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer Inc. ### Does COVID-19 mRNA (Pfizer) vaccine interact with my other drugs? Enter medications to view a detailed interaction report using our [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html). ## Frequently asked questions - [Can you become immune to COVID-19?](https://www.drugs.com/medical-answers/you-immune-covid-19-3537185/) - [COVID-19 vaccines and variants: What you should know](https://www.drugs.com/medical-answers/coronavirus-mutate-3535321/) ## More about COVID-19 mRNA (Pfizer) vaccine - [Check interactions](https://www.drugs.com/drug-interactions/covid-19-mrna-pfizer-vaccine.html) - [Compare alternatives](https://www.drugs.com/compare/covid-19-mrna-pfizer-vaccine) - [Reviews (18)](https://www.drugs.com/comments/covid-19-mrna-pfizer-vaccine/for-covid-19.html) - [Latest FDA alerts (1)](https://www.drugs.com/fda-alerts/4638-0.html) - [Dosage information](https://www.drugs.com/dosage/covid-19-mrna-pfizer-vaccine.html) - [During pregnancy](https://www.drugs.com/pregnancy/covid-19-mrna-pfizer-vaccine.html) - [Drug class: viral vaccines](https://www.drugs.com/drug-class/viral-vaccines.html) ### Patient resources - [Sars-cov-2 (covid-19) vaccine, mrna (pfizer) advanced reading](https://www.drugs.com/cons/sars-cov-2-covid-19-vaccine-mrna-pfizer.html) #### Other brands [Comirnaty](https://www.drugs.com/comirnaty.html), [Pfizer-BioNTech COVID-19 Vaccine](https://www.drugs.com/pfizer-biontech-covid-19-vaccine.html) ### Professional resources - [COVID-19 Vaccine, mRNA (Pfizer-BioNTech) (2025-2026 Formula) monograph](https://www.drugs.com/monograph/covid-19-vaccine-mrna-pfizer-biontech-2025-2026-formula.html) - [Covid-19 Vaccine Pfizer (FDA)](https://www.drugs.com/pro/covid-19-vaccine-pfizer.html) - [Covid-19 Vaccine Pfizer, Bivalent (FDA)](https://www.drugs.com/pro/covid-19-vaccine-pfizer-bivalent.html) - [Covid-19 Vaccine Pfizer, Monovalent, 6 mo-4 yr (FDA)](https://www.drugs.com/pro/covid-19-vaccine-pfizer-monovalent-6-mo-4-yr.html) - [Covid-19 Vaccine Pfizer, Monovalent,5 yr to 11 yr (FDA)](https://www.drugs.com/pro/covid-19-vaccine-pfizer-monovalent-5-yr-to-11-yr.html) - [Pfizer-BioNTech Vaccine (FDA)](https://www.drugs.com/pro/pfizer-biontech-vaccine.html) #### Other brands [Comirnaty](https://www.drugs.com/pro/comirnaty.html) ### Related treatment guides - [COVID-19](https://www.drugs.com/condition/covid-19.html) ## Further information COVID-19 mRNA (Pfizer) vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following [this guide](https://www.drugs.com/fda-consumer/your-guide-to-reporting-problems-to-fda-71.html). [Medical Disclaimer](https://www.drugs.com/support/disclaimer.html) Drug Status Availability Prescription only Rx [Pregnancy & Lactation](https://www.drugs.com/pregnancy/covid-19-mrna-pfizer-vaccine.html) Risk data available CSA Schedule\* Not a controlled drug N/A Loading... User Reviews & Ratings 7\.2 / 10 [18 Reviews](https://www.drugs.com/comments/covid-19-mrna-pfizer-vaccine/) Drugs.com Mobile App Access drug & treatment information, identify pills, check interactions and set up personal medication records. 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Readable Markdown	[Medically reviewed](https://www.drugs.com/support/editorial-policy.html#editorial-staff) by Drugs.com. Last updated on Sep 15, 2025. - [Serious side effects](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#serious-side-effects) - [Other side effects](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#other-side-effects) - [Professional info](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#professional-info) - [FAQ](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#faq) Applies to [COVID-19 mRNA (Pfizer) vaccine](https://www.drugs.com/cons/sars-cov-2-covid-19-vaccine-mrna-pfizer.html): intramuscular suspension. Intramuscular route (suspension) Although the licensed vaccine ([Comirnaty](https://www.drugs.com/comirnaty.html)®) is FDA-approved in patients aged 16 or older for 2 doses , [Pfizer-BioNTech COVID-19 vaccine](https://www.drugs.com/pfizer-biontech-covid-19-vaccine.html) is an unapproved product authorized for emergency use in individuals aged 12 through 15 years and to provide a third dose to individuals aged 12 years or older who are solid [organ transplant](https://www.drugs.com/cg/liver-transplant-discharge-care.html) recipients or have an equivalent level of immunocompromise. ## Precautions Be sure to notify your doctor of any side effects (eg, feeling faint, especially in teenagers) that occur after you receive this vaccine. [Fainting](https://www.drugs.com/cg/syncope.html) may occur after you receive this vaccine. Your doctor may want you to be observed after you get the injection to prevent and manage fainting. This vaccine may cause serious allergic reactions, including [anaphylaxis](https://www.drugs.com/cg/anaphylaxis.html), which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, a [fast heartbeat](https://www.drugs.com/cg/tachycardia.html), trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the vaccine. This vaccine may increase your risk of serious heart problems (eg, myocarditis, [pericarditis](https://www.drugs.com/health-guide/pericarditis.html)), especially after you receive the second dose. Check with your doctor right away if you have anxiety, blue or pale skin, chest pain, possibly moving to the left arm, neck, or shoulder, fever, chills, a fast heartbeat, trouble breathing, or unusual tiredness or weakness. This vaccine may not protect everyone who receives it. This vaccine will not treat symptoms of COVID-19 infection if you already have the disease. It is very important that you take precautions to reduce the risk of COVID-19. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter \[OTC\]) medicines and herbal or vitamin supplements. ## Serious side effects Along with its needed effects, COVID-19 mRNA (Pfizer) vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur while taking COVID-19 mRNA (Pfizer) vaccine: ### More common side effects - chills - [diarrhea](https://www.drugs.com/health-guide/diarrhea.html) - fever - [headache](https://www.drugs.com/cg/tension-headache.html) - irritability - joint or [muscle pain](https://www.drugs.com/cg/ankle-sprain.html) - swollen, painful, or tender lymph glands in the neck, armpit, or groin - unusual tiredness or weakness ### Less common side effects ### Rare side effects - decreased appetite - general feeling of discomfort or illness - pain in the arms - rash ### Incidence not known - anxiety - blue or pale skin - chest discomfort or tightness - chest pain, possible moving to the left arm, neck, or shoulder - cough - [difficulty swallowing](https://www.drugs.com/cg/dysphagia.html) - dizziness - fast heartbeat - fainting - large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs - puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue - trouble breathing ## Other side effects Some side effects of COVID-19 mRNA (Pfizer) vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: ### More common side effects - pain, redness, or swelling at the injection site ## For healthcare professionals Applies to COVID-19 mRNA (Pfizer) vaccine: intramuscular suspension. ### General adverse events The most commonly reported side effects included injection site pain, fatigue, and headache.\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Cardiovascular - Postmarketing reports: Myocarditis, pericarditis\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Dermatologic - Frequency not reported: Hyperhidrosis, night sweats - Postmarketing reports: [Pruritus](https://www.drugs.com/cg/itchy-skin.html), rash, [urticaria](https://www.drugs.com/cg/urticaria.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Gastrointestinal - Very common (10% or more): Diarrhea (up to 11.1%) - Common (1% to 10%): Vomiting - Frequency not reported: Nausea\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Hematologic - Common (1% to 10%): [Lymphadenopathy](https://www.drugs.com/cg/lymphadenopathy.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Hypersensitivity - Postmarketing reports: Anaphylaxis, [angioedema](https://www.drugs.com/cg/angioedema.html), other hypersensitivity reactions (e.g., pruritus, rash, urticaria), severe allergic reactions\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Local - Very common (10% or more): Injection site pain (up to 90.5%), injection site swelling (up to 11.8%), injection site redness (up to 10.4%) - Postmarketing reports: Extremity (arm) pain\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Metabolic - Frequency not reported: Decreased appetite\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Musculoskeletal - Very common (10% or more): Chills (up to 49.2%), muscle pain (up to 45.5%), new/worsened muscle pain (up to 39.3%), [joint pain](https://www.drugs.com/cg/osteoarthritis.html) (up to 27.5%), new/worsened joint pain (up to 23.8%)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Nervous system - Very common (10% or more): Headache (up to 75.5%) - Frequency not reported: Bell's palsy/facial paralysis, [lethargy](https://www.drugs.com/cg/fatigue.html) - Postmarketing reports: Dizziness, [syncope](https://www.drugs.com/cg/syncope.html)\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] ### Other - Very common (10% or more): Fatigue (up to 77.5%), use of antipyretic or pain medication (up to 50.8%), fever (up to 24.3%) - Frequency not reported: Asthenia, malaise, febrile seizures\[[Ref](https://www.drugs.com/sfx/covid-19-mrna-pfizer-vaccine-side-effects.html#refs)\] #### References 1\. (2023) "Product Information. Comirnaty (2023-2024) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 2\. (2024) "Product Information. Comirnaty (2024-2025) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer U.S. Pharmaceuticals Group 3\. (2025) "Product Information. Comirnaty (2025-2026) PF (cvx 309) (SARS-CoV-2 (COVID-19) mRNA-LNP vaccine (cvx 309))." Pfizer Inc. ### Does COVID-19 mRNA (Pfizer) vaccine interact with my other drugs? Enter medications to view a detailed interaction report using our [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html). ## Frequently asked questions - [Can you become immune to COVID-19?](https://www.drugs.com/medical-answers/you-immune-covid-19-3537185/) - [COVID-19 vaccines and variants: What you should know](https://www.drugs.com/medical-answers/coronavirus-mutate-3535321/) ## Further information COVID-19 mRNA (Pfizer) vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following [this guide](https://www.drugs.com/fda-consumer/your-guide-to-reporting-problems-to-fda-71.html). [Medical Disclaimer](https://www.drugs.com/support/disclaimer.html)
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