🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 131 (from laksa014)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa131.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/drug-class/ssri-antidepressants.html\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/drug-class/ssri-antidepressants.html\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html","crawl_time":1775512078,"first_indexed_time":1465495056,"http_code":200,"src_unparsed":"com,drugs!www,\/drug-class\/ssri-antidepressants.html s443","src_root_hash":"1816286668162245731","history_drop_reason":null,"meta_title":"SSRI Drugs - List of Common Brands & Generics - Drugs.com","meta_descriptions":["Browse the full SSRI drugs list of common brands and generics. See how each medication works, review side effects, doses and savings tips."],"attrs_boilerpipe_text":"Other names:\nSSRI, SSRIs\nWhat are SSRI drugs?\nSSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain.\nSerotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that\ndepression\nwas caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case.\nSSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect.\nAntidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants.\nWhat are SSRI antidepressants used for?\nSSRI antidepressants help to relieve symptoms of\ndepression\nsuch as low mood, irritability, feelings of worthlessness, restlessness,\nanxiety\n, and difficulty in sleeping.\nThey are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants.\nIn addition to\ndepression\n, SSRIs may also be used to treat a range of other conditions, for example:\nAnxiety\nBulimia nervosa\nFibromyalgia\nHot flashes\nObsessive-compulsive disorder\nPanic disorder\nPost-Traumatic Stress Disorder\nPremenstrual dysphoric disorder\nSome reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen.\nWhat are the differences between SSRI antidepressants?\nAlthough all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example,\nfluoxetine\n,\nfluvoxamine\n, and\nparoxetine\nare more likely to interact with other medications than\ncitalopram\n,\nescitalopram\nand\nsertraline\n.\nGeneric name\nBrand name examples\ncitalopram\nCelexa\nescitalopram\nLexapro\nfluoxetine\nProzac\n,\nSarafem\nfluvoxamine\nLuvox\nparoxetine\nBrisdelle\n,\nPaxil\n,\nPexeva\nsertraline\nZoloft\nvilazodone\n*\nViibryd\n*Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS. \nAre SSRI antidepressants safe?\nWhen taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as:\nAn increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy\nSerotonin syndrome\n– this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as\ndextromethorphan\n,\ntramadol\n, and\nSt. John's Wort\n). Symptoms include\nagitation\n, confusion,\nsweating\n, tremors, and a rapid heart rate\nAn increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk.\nIn addition, some SSRIs, such as\ncitalopram\nhave been associated with abnormal heart rhythms with higher dosages.\nWhat are the side effects of SSRI antidepressants?\nNot everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include:\nBlurred vision\nDizziness\nDrowsiness\n(fluoxetine is more likely to cause\ninsomnia\n)\nDry mouth\nGastrointestinal upset (such as\nconstipation\n,\ndiarrhea\n, or\nnausea\n)\nHeadache\nSexual dysfunction (such as reduced desire or\nerectile dysfunction\n).\nSeveral SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly.\nFor a complete list of side effects, please refer to the individual drug monographs.\nList of Selective serotonin reuptake inhibitors\nView by:\nGeneric\n•\nBrand\nFilter by\nDrug Name\nAvg. Rating\nReviews\nsertraline systemic\n(\nPro\n)\nBrand name:\nZoloft\n7.3\n4,659 reviews\nescitalopram systemic\n(\nPro\n)\nBrand name:\nLexapro\n7.5\n4,032 reviews\nfluoxetine systemic\n(\nPro\n)\nBrand name:\nProzac\n7.4\n2,277 reviews\ncitalopram systemic\n(\nPro\n)\nBrand name:\nCelexa\n7.4\n2,250 reviews\nparoxetine systemic\n(\nPro\n)\nBrand names:\nPaxil CR\n,\nPaxil\n,\nBrisdelle\n7.1\n1,564 reviews\nfluvoxamine systemic\n(\nPro\n)\n6.8\n391 reviews\nFor ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective).\nFurther information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\nMedical Disclaimer","attrs_markdown":"[Skip to main content](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html#content)\n\n[![Drugs.com - Go to homepage](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo.svg)](https:\/\/www.drugs.com\/)\n\n[Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n\nSite navigation\n\n- [**Upgrade to a Plus Plan** Remove ads and unlock more features.](https:\/\/www.drugs.com\/account\/plan\/?launch=ddc-tier-1)\n- [Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n- [Drugs A-Z](https:\/\/www.drugs.com\/drug_information.html)\n- [Pill Identifier](https:\/\/www.drugs.com\/pill_identification.html)\n- [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html)\n- [Compare Drugs](https:\/\/www.drugs.com\/compare\/)\n- [News](https:\/\/www.drugs.com\/news.html)\n- [Pro Edition](https:\/\/www.drugs.com\/professionals.html)\n- [More Resources](https:\/\/www.drugs.com\/sitemap.html)\n- [Help & Support](https:\/\/www.drugs.com\/support\/)\n\nClose\n\n1. [Home](https:\/\/www.drugs.com\/)\n2. [Drug Classes](https:\/\/www.drugs.com\/drug-classes.html)\n3. [Psychotherapeutic Agents](https:\/\/www.drugs.com\/drug-class\/psychotherapeutic-agents.html)\n4. [Antidepressants](https:\/\/www.drugs.com\/drug-class\/antidepressants.html)\n5. Selective Serotonin Reuptake Inhibitors\n\nPrint\n# SSRI Drugs List\nMedically reviewed by [Carmen Pope, BPharm](https:\/\/www.drugs.com\/support\/editor\/19\/carmen-pope-bpharm.html). Last updated on April 14, 2023.\n\n**Other names:** SSRI, SSRIs\n\n## What are SSRI drugs?\nSSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain.\n\nSerotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that [depression](https:\/\/www.drugs.com\/cg\/depression.html) was caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case.\n\nSSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect.\n\nAntidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants.\n\n## What are SSRI antidepressants used for?\nSSRI antidepressants help to relieve symptoms of [depression](https:\/\/www.drugs.com\/health-guide\/depression.html) such as low mood, irritability, feelings of worthlessness, restlessness, [anxiety](https:\/\/www.drugs.com\/cg\/anxiety.html), and difficulty in sleeping.\n\nThey are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants.\n\nIn addition to [depression](https:\/\/www.drugs.com\/health-guide\/depression.html), SSRIs may also be used to treat a range of other conditions, for example:\n\n- [Anxiety](https:\/\/www.drugs.com\/health-guide\/generalized-anxiety-disorder.html)\n- [Bulimia nervosa](https:\/\/www.drugs.com\/cg\/bulimia.html)\n- [Fibromyalgia](https:\/\/www.drugs.com\/cg\/fibromyalgia.html)\n- [Hot flashes](https:\/\/www.drugs.com\/health-guide\/hot-flashes.html)\n- [Obsessive-compulsive disorder](https:\/\/www.drugs.com\/cg\/obsessive-compulsive-disorder.html)\n- [Panic disorder](https:\/\/www.drugs.com\/cg\/panic-disorder.html)\n- [Post-Traumatic Stress Disorder](https:\/\/www.drugs.com\/cg\/post-traumatic-stress-disorder.html)\n- Premenstrual dysphoric disorder\n\nSome reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen.\n\n## What are the differences between SSRI antidepressants?\nAlthough all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example, [fluoxetine](https:\/\/www.drugs.com\/fluoxetine.html), [fluvoxamine](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html), and [paroxetine](https:\/\/www.drugs.com\/paroxetine.html) are more likely to interact with other medications than [citalopram](https:\/\/www.drugs.com\/citalopram.html), [escitalopram](https:\/\/www.drugs.com\/escitalopram.html) and [sertraline](https:\/\/www.drugs.com\/sertraline.html).\n\n| Generic name | Brand name examples |\n|---|---|\n| [citalopram](https:\/\/www.drugs.com\/citalopram.html) | [Celexa](https:\/\/www.drugs.com\/celexa.html) |\n| [escitalopram](https:\/\/www.drugs.com\/escitalopram.html) | [Lexapro](https:\/\/www.drugs.com\/lexapro.html) |\n| [fluoxetine](https:\/\/www.drugs.com\/fluoxetine.html) | [Prozac](https:\/\/www.drugs.com\/prozac.html), [Sarafem](https:\/\/www.drugs.com\/mtm\/sarafem.html) |\n| [fluvoxamine](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html) | [Luvox](https:\/\/www.drugs.com\/mtm\/luvox.html) |\n| [paroxetine](https:\/\/www.drugs.com\/paroxetine.html) | [Brisdelle](https:\/\/www.drugs.com\/brisdelle.html), [Paxil](https:\/\/www.drugs.com\/paxil.html), [Pexeva](https:\/\/www.drugs.com\/mtm\/pexeva.html) |\n| [sertraline](https:\/\/www.drugs.com\/sertraline.html) | [Zoloft](https:\/\/www.drugs.com\/zoloft.html) |\n| [vilazodone](https:\/\/www.drugs.com\/mtm\/vilazodone.html)\\* | [Viibryd](https:\/\/www.drugs.com\/viibryd.html) |\n\n\\*Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS.\n\n## Are SSRI antidepressants safe?\nWhen taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as:\n\n- An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy\n- [Serotonin syndrome](https:\/\/www.drugs.com\/cg\/serotonin-syndrome.html) – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as [dextromethorphan](https:\/\/www.drugs.com\/dextromethorphan.html), [tramadol](https:\/\/www.drugs.com\/tramadol.html), and [St. John's Wort](https:\/\/www.drugs.com\/mtm\/st-john-s-wort.html)). Symptoms include [agitation](https:\/\/www.drugs.com\/condition\/agitation.html), confusion, [sweating](https:\/\/www.drugs.com\/condition\/hyperhidrosis.html), tremors, and a rapid heart rate\n- An increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk.\n\nIn addition, some SSRIs, such as [citalopram](https:\/\/www.drugs.com\/citalopram.html) have been associated with abnormal heart rhythms with higher dosages.\n\n## What are the side effects of SSRI antidepressants?\nNot everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include:\n\n- Blurred vision\n- Dizziness\n- [Drowsiness](https:\/\/www.drugs.com\/condition\/drowsiness.html) (fluoxetine is more likely to cause [insomnia](https:\/\/www.drugs.com\/cg\/insomnia.html))\n- [Dry mouth](https:\/\/www.drugs.com\/cg\/dry-mouth.html)\n- Gastrointestinal upset (such as [constipation](https:\/\/www.drugs.com\/cg\/constipation.html), [diarrhea](https:\/\/www.drugs.com\/health-guide\/diarrhea.html), or [nausea](https:\/\/www.drugs.com\/health-guide\/nausea.html))\n- [Headache](https:\/\/www.drugs.com\/cg\/tension-headache.html)\n- Sexual dysfunction (such as reduced desire or [erectile dysfunction](https:\/\/www.drugs.com\/cg\/erectile-dysfunction.html)).\n\nSeveral SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly.\n\nFor a complete list of side effects, please refer to the individual drug monographs.\n## List of Selective serotonin reuptake inhibitors\nView by: **Generic** • [Brand](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=0&sort=reviews&order=desc#filterSection)\n\nFilter by\n\n| [Drug Name](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=drug&order=asc#filterSection) | [Avg. Rating](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=rating&order=desc#filterSection) | [Reviews](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=reviews&order=asc#filterSection) |\n|---|---|---|\n| [**sertraline systemic**](https:\/\/www.drugs.com\/sertraline.html \"sertraline systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/sertraline.html \"sertraline systemic for Health Professionals\")) **Brand name:** [Zoloft](https:\/\/www.drugs.com\/zoloft.html) | 7\\.3 | [4,659 reviews](https:\/\/www.drugs.com\/comments\/sertraline\/) |\n| [**escitalopram systemic**](https:\/\/www.drugs.com\/escitalopram.html \"escitalopram systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/escitalopram.html \"escitalopram systemic for Health Professionals\")) **Brand name:** [Lexapro](https:\/\/www.drugs.com\/lexapro.html) | 7\\.5 | [4,032 reviews](https:\/\/www.drugs.com\/comments\/escitalopram\/) |\n| [**fluoxetine systemic**](https:\/\/www.drugs.com\/fluoxetine.html \"fluoxetine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/fluoxetine.html \"fluoxetine systemic for Health Professionals\")) **Brand name:** [Prozac](https:\/\/www.drugs.com\/prozac.html) | 7\\.4 | [2,277 reviews](https:\/\/www.drugs.com\/comments\/fluoxetine\/) |\n| [**citalopram systemic**](https:\/\/www.drugs.com\/citalopram.html \"citalopram systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/citalopram.html \"citalopram systemic for Health Professionals\")) **Brand name:** [Celexa](https:\/\/www.drugs.com\/celexa.html) | 7\\.4 | [2,250 reviews](https:\/\/www.drugs.com\/comments\/citalopram\/) |\n| [**paroxetine systemic**](https:\/\/www.drugs.com\/paroxetine.html \"paroxetine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/paroxetine.html \"paroxetine systemic for Health Professionals\")) **Brand names:** [Paxil CR](https:\/\/www.drugs.com\/mtm\/paxil-cr.html), [Paxil](https:\/\/www.drugs.com\/paxil.html), [Brisdelle](https:\/\/www.drugs.com\/brisdelle.html) | 7\\.1 | [1,564 reviews](https:\/\/www.drugs.com\/comments\/paroxetine\/) |\n| [**fluvoxamine systemic**](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html \"fluvoxamine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/fluvoxamine.html \"fluvoxamine systemic for Health Professionals\")) | 6\\.8 | [391 reviews](https:\/\/www.drugs.com\/comments\/fluvoxamine\/) |\n| For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |   |   |\n\n## See also\nMedical conditions treated or associated with selective serotonin reuptake inhibitors:\n\n- [Anxiety](https:\/\/www.drugs.com\/condition\/anxiety.html)\n- [Anxiety and Stress](https:\/\/www.drugs.com\/condition\/anxiety-stress.html)\n- [Bulimia](https:\/\/www.drugs.com\/condition\/bulimia.html)\n- [Depression](https:\/\/www.drugs.com\/condition\/depression.html)\n- [Generalized Anxiety Disorder](https:\/\/www.drugs.com\/condition\/generalized-anxiety-disorder.html)\n- [Hot Flashes](https:\/\/www.drugs.com\/condition\/hot-flashes.html)\n- [Major Depressive Disorder](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html)\n- [Obsessive Compulsive Disorder](https:\/\/www.drugs.com\/condition\/obsessive-compulsive-disorder.html)\n- [Panic Disorder](https:\/\/www.drugs.com\/condition\/panic-disorder.html)\n- [Post Traumatic Stress Disorder](https:\/\/www.drugs.com\/condition\/post-traumatic-stress-disorder.html)\n- [Postmenopausal Symptoms](https:\/\/www.drugs.com\/condition\/postmenopausal-symptoms.html)\n- [Postpartum Depression](https:\/\/www.drugs.com\/condition\/postpartum-depression.html)\n- [Premature Ejaculation](https:\/\/www.drugs.com\/condition\/premature-ejaculation.html)\n- [Premenstrual Dysphoric Disorder](https:\/\/www.drugs.com\/condition\/premenstrual-dysphoric-disorder.html)\n- [Schizoaffective Disorder](https:\/\/www.drugs.com\/condition\/schizoaffective-disorder.html)\n- [Social Anxiety Disorder](https:\/\/www.drugs.com\/condition\/social-anxiety-disorder.html)\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)\n\n**Drugs.com Mobile App**\n\nAccess drug & treatment information, identify pills, check interactions and set up personal medication records.\n\n[Download the Medication Guide app on iTunes ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/apple-store.png)](https:\/\/apps.apple.com\/us\/app\/drugs-com-medication-guide\/id599471042?platform=iphone)   [Download the Medication Guide app on the Google Play store 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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Mar 31, 2026), Cerner Multum™ (updated Mar 29, 2026), ASHP (updated Mar 10, 2026) and others.\n\n[![Certified by TRUSTe](https:\/\/privacy-policy.truste.com\/privacy-seal\/seal?rid=d18cba4a-afc4-4863-af81-8262bb120271)](https:\/\/privacy.truste.com\/privacy-seal\/validation?rid=d18cba4a-afc4-4863-af81-8262bb120271)  ![Verified by TAG](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/tag-verified.png)  [![This website is certified by AACI. Click to verify.](https:\/\/www.drugs.com\/img\/v-20251028\/logo\/vendor\/trust-mark-logo.png)](https:\/\/aacihealthcare.com\/certificates\/c173-2022-trust-us\/)   [![AdChoices - Ad privacy information](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/adchoices-logomark.png)](https:\/\/www.drugs.com\/support\/privacy\/advertising.html)\n\nCopyright © 2000-2026 Drugs.com. All rights reserved.","attrs_readable_markdown":"**Other names:** SSRI, SSRIs\n\n## What are SSRI drugs?\nSSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain.\n\nSerotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that [depression](https:\/\/www.drugs.com\/cg\/depression.html) was caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case.\n\nSSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect.\n\nAntidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants.\n\n## What are SSRI antidepressants used for?\nSSRI antidepressants help to relieve symptoms of [depression](https:\/\/www.drugs.com\/health-guide\/depression.html) such as low mood, irritability, feelings of worthlessness, restlessness, [anxiety](https:\/\/www.drugs.com\/cg\/anxiety.html), and difficulty in sleeping.\n\nThey are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants.\n\nIn addition to [depression](https:\/\/www.drugs.com\/health-guide\/depression.html), SSRIs may also be used to treat a range of other conditions, for example:\n\n- [Anxiety](https:\/\/www.drugs.com\/health-guide\/generalized-anxiety-disorder.html)\n- [Bulimia nervosa](https:\/\/www.drugs.com\/cg\/bulimia.html)\n- [Fibromyalgia](https:\/\/www.drugs.com\/cg\/fibromyalgia.html)\n- [Hot flashes](https:\/\/www.drugs.com\/health-guide\/hot-flashes.html)\n- [Obsessive-compulsive disorder](https:\/\/www.drugs.com\/cg\/obsessive-compulsive-disorder.html)\n- [Panic disorder](https:\/\/www.drugs.com\/cg\/panic-disorder.html)\n- [Post-Traumatic Stress Disorder](https:\/\/www.drugs.com\/cg\/post-traumatic-stress-disorder.html)\n- Premenstrual dysphoric disorder\n\nSome reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen.\n\n## What are the differences between SSRI antidepressants?\nAlthough all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example, [fluoxetine](https:\/\/www.drugs.com\/fluoxetine.html), [fluvoxamine](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html), and [paroxetine](https:\/\/www.drugs.com\/paroxetine.html) are more likely to interact with other medications than [citalopram](https:\/\/www.drugs.com\/citalopram.html), [escitalopram](https:\/\/www.drugs.com\/escitalopram.html) and [sertraline](https:\/\/www.drugs.com\/sertraline.html).\n\n| Generic name | Brand name examples |\n|---|---|\n| [citalopram](https:\/\/www.drugs.com\/citalopram.html) | [Celexa](https:\/\/www.drugs.com\/celexa.html) |\n| [escitalopram](https:\/\/www.drugs.com\/escitalopram.html) | [Lexapro](https:\/\/www.drugs.com\/lexapro.html) |\n| [fluoxetine](https:\/\/www.drugs.com\/fluoxetine.html) | [Prozac](https:\/\/www.drugs.com\/prozac.html), [Sarafem](https:\/\/www.drugs.com\/mtm\/sarafem.html) |\n| [fluvoxamine](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html) | [Luvox](https:\/\/www.drugs.com\/mtm\/luvox.html) |\n| [paroxetine](https:\/\/www.drugs.com\/paroxetine.html) | [Brisdelle](https:\/\/www.drugs.com\/brisdelle.html), [Paxil](https:\/\/www.drugs.com\/paxil.html), [Pexeva](https:\/\/www.drugs.com\/mtm\/pexeva.html) |\n| [sertraline](https:\/\/www.drugs.com\/sertraline.html) | [Zoloft](https:\/\/www.drugs.com\/zoloft.html) |\n| [vilazodone](https:\/\/www.drugs.com\/mtm\/vilazodone.html)\\* | [Viibryd](https:\/\/www.drugs.com\/viibryd.html) |\n\n\\*Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS.\n\n## Are SSRI antidepressants safe?\nWhen taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as:\n\n- An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy\n- [Serotonin syndrome](https:\/\/www.drugs.com\/cg\/serotonin-syndrome.html) – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as [dextromethorphan](https:\/\/www.drugs.com\/dextromethorphan.html), [tramadol](https:\/\/www.drugs.com\/tramadol.html), and [St. John's Wort](https:\/\/www.drugs.com\/mtm\/st-john-s-wort.html)). Symptoms include [agitation](https:\/\/www.drugs.com\/condition\/agitation.html), confusion, [sweating](https:\/\/www.drugs.com\/condition\/hyperhidrosis.html), tremors, and a rapid heart rate\n- An increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk.\n\nIn addition, some SSRIs, such as [citalopram](https:\/\/www.drugs.com\/citalopram.html) have been associated with abnormal heart rhythms with higher dosages.\n\n## What are the side effects of SSRI antidepressants?\nNot everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include:\n\n- Blurred vision\n- Dizziness\n- [Drowsiness](https:\/\/www.drugs.com\/condition\/drowsiness.html) (fluoxetine is more likely to cause [insomnia](https:\/\/www.drugs.com\/cg\/insomnia.html))\n- [Dry mouth](https:\/\/www.drugs.com\/cg\/dry-mouth.html)\n- Gastrointestinal upset (such as [constipation](https:\/\/www.drugs.com\/cg\/constipation.html), [diarrhea](https:\/\/www.drugs.com\/health-guide\/diarrhea.html), or [nausea](https:\/\/www.drugs.com\/health-guide\/nausea.html))\n- [Headache](https:\/\/www.drugs.com\/cg\/tension-headache.html)\n- Sexual dysfunction (such as reduced desire or [erectile dysfunction](https:\/\/www.drugs.com\/cg\/erectile-dysfunction.html)).\n\nSeveral SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly.\n\nFor a complete list of side effects, please refer to the individual drug monographs.\n## List of Selective serotonin reuptake inhibitors\nView by: **Generic** • [Brand](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=0&sort=reviews&order=desc#filterSection)\n\nFilter by\n\n| [Drug Name](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=drug&order=asc#filterSection) | [Avg. Rating](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=rating&order=desc#filterSection) | [Reviews](https:\/\/www.drugs.com\/drug-class\/ssri-antidepressants.html?condition_id=0&generic=1&sort=reviews&order=asc#filterSection) |\n|---|---|---|\n| [**sertraline systemic**](https:\/\/www.drugs.com\/sertraline.html \"sertraline systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/sertraline.html \"sertraline systemic for Health Professionals\")) **Brand name:** [Zoloft](https:\/\/www.drugs.com\/zoloft.html) | 7\\.3 | [4,659 reviews](https:\/\/www.drugs.com\/comments\/sertraline\/) |\n| [**escitalopram systemic**](https:\/\/www.drugs.com\/escitalopram.html \"escitalopram systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/escitalopram.html \"escitalopram systemic for Health Professionals\")) **Brand name:** [Lexapro](https:\/\/www.drugs.com\/lexapro.html) | 7\\.5 | [4,032 reviews](https:\/\/www.drugs.com\/comments\/escitalopram\/) |\n| [**fluoxetine systemic**](https:\/\/www.drugs.com\/fluoxetine.html \"fluoxetine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/fluoxetine.html \"fluoxetine systemic for Health Professionals\")) **Brand name:** [Prozac](https:\/\/www.drugs.com\/prozac.html) | 7\\.4 | [2,277 reviews](https:\/\/www.drugs.com\/comments\/fluoxetine\/) |\n| [**citalopram systemic**](https:\/\/www.drugs.com\/citalopram.html \"citalopram systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/citalopram.html \"citalopram systemic for Health Professionals\")) **Brand name:** [Celexa](https:\/\/www.drugs.com\/celexa.html) | 7\\.4 | [2,250 reviews](https:\/\/www.drugs.com\/comments\/citalopram\/) |\n| [**paroxetine systemic**](https:\/\/www.drugs.com\/paroxetine.html \"paroxetine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/paroxetine.html \"paroxetine systemic for Health Professionals\")) **Brand names:** [Paxil CR](https:\/\/www.drugs.com\/mtm\/paxil-cr.html), [Paxil](https:\/\/www.drugs.com\/paxil.html), [Brisdelle](https:\/\/www.drugs.com\/brisdelle.html) | 7\\.1 | [1,564 reviews](https:\/\/www.drugs.com\/comments\/paroxetine\/) |\n| [**fluvoxamine systemic**](https:\/\/www.drugs.com\/mtm\/fluvoxamine.html \"fluvoxamine systemic for Consumers\") ([Pro](https:\/\/www.drugs.com\/monograph\/fluvoxamine.html \"fluvoxamine systemic for Health Professionals\")) | 6\\.8 | [391 reviews](https:\/\/www.drugs.com\/comments\/fluvoxamine\/) |\n| For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |   |   |\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)","meta_canonical":null}

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URL	https://www.drugs.com/drug-class/ssri-antidepressants.html
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Boilerpipe Text	Other names: SSRI, SSRIs What are SSRI drugs? SSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain. Serotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that depression was caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case. SSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect. Antidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants. What are SSRI antidepressants used for? SSRI antidepressants help to relieve symptoms of depression such as low mood, irritability, feelings of worthlessness, restlessness, anxiety , and difficulty in sleeping. They are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants. In addition to depression , SSRIs may also be used to treat a range of other conditions, for example: Anxiety Bulimia nervosa Fibromyalgia Hot flashes Obsessive-compulsive disorder Panic disorder Post-Traumatic Stress Disorder Premenstrual dysphoric disorder Some reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen. What are the differences between SSRI antidepressants? Although all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example, fluoxetine , fluvoxamine , and paroxetine are more likely to interact with other medications than citalopram , escitalopram and sertraline . Generic name Brand name examples citalopram Celexa escitalopram Lexapro fluoxetine Prozac , Sarafem fluvoxamine Luvox paroxetine Brisdelle , Paxil , Pexeva sertraline Zoloft vilazodone * Viibryd *Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS. Are SSRI antidepressants safe? When taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as: An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy Serotonin syndrome – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as dextromethorphan , tramadol , and St. John's Wort ). Symptoms include agitation , confusion, sweating , tremors, and a rapid heart rate An increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk. In addition, some SSRIs, such as citalopram have been associated with abnormal heart rhythms with higher dosages. What are the side effects of SSRI antidepressants? Not everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include: Blurred vision Dizziness Drowsiness (fluoxetine is more likely to cause insomnia ) Dry mouth Gastrointestinal upset (such as constipation , diarrhea , or nausea ) Headache Sexual dysfunction (such as reduced desire or erectile dysfunction ). Several SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly. For a complete list of side effects, please refer to the individual drug monographs. List of Selective serotonin reuptake inhibitors View by: Generic • Brand Filter by Drug Name Avg. Rating Reviews sertraline systemic ( Pro ) Brand name: Zoloft 7.3 4,659 reviews escitalopram systemic ( Pro ) Brand name: Lexapro 7.5 4,032 reviews fluoxetine systemic ( Pro ) Brand name: Prozac 7.4 2,277 reviews citalopram systemic ( Pro ) Brand name: Celexa 7.4 2,250 reviews paroxetine systemic ( Pro ) Brand names: Paxil CR , Paxil , Brisdelle 7.1 1,564 reviews fluvoxamine systemic ( Pro ) 6.8 391 reviews For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Medical Disclaimer
Markdown	[Skip to main content](https://www.drugs.com/drug-class/ssri-antidepressants.html#content) [![Drugs.com - Go to homepage](https://www.drugs.com/img/logo/drugscom-logo.svg)](https://www.drugs.com/) [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) Site navigation - [Upgrade to a Plus Plan Remove ads and unlock more features.](https://www.drugs.com/account/plan/?launch=ddc-tier-1) - [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) - [Drugs A-Z](https://www.drugs.com/drug_information.html) - [Pill Identifier](https://www.drugs.com/pill_identification.html) - [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html) - [Compare Drugs](https://www.drugs.com/compare/) - [News](https://www.drugs.com/news.html) - [Pro Edition](https://www.drugs.com/professionals.html) - [More Resources](https://www.drugs.com/sitemap.html) - [Help & Support](https://www.drugs.com/support/) Close 1. [Home](https://www.drugs.com/) 2. [Drug Classes](https://www.drugs.com/drug-classes.html) 3. [Psychotherapeutic Agents](https://www.drugs.com/drug-class/psychotherapeutic-agents.html) 4. [Antidepressants](https://www.drugs.com/drug-class/antidepressants.html) 5. Selective Serotonin Reuptake Inhibitors Print # SSRI Drugs List Medically reviewed by [Carmen Pope, BPharm](https://www.drugs.com/support/editor/19/carmen-pope-bpharm.html). Last updated on April 14, 2023. Other names: SSRI, SSRIs ## What are SSRI drugs? SSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain. Serotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that [depression](https://www.drugs.com/cg/depression.html) was caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case. SSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect. Antidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants. ## What are SSRI antidepressants used for? SSRI antidepressants help to relieve symptoms of [depression](https://www.drugs.com/health-guide/depression.html) such as low mood, irritability, feelings of worthlessness, restlessness, [anxiety](https://www.drugs.com/cg/anxiety.html), and difficulty in sleeping. They are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants. In addition to [depression](https://www.drugs.com/health-guide/depression.html), SSRIs may also be used to treat a range of other conditions, for example: - [Anxiety](https://www.drugs.com/health-guide/generalized-anxiety-disorder.html) - [Bulimia nervosa](https://www.drugs.com/cg/bulimia.html) - [Fibromyalgia](https://www.drugs.com/cg/fibromyalgia.html) - [Hot flashes](https://www.drugs.com/health-guide/hot-flashes.html) - [Obsessive-compulsive disorder](https://www.drugs.com/cg/obsessive-compulsive-disorder.html) - [Panic disorder](https://www.drugs.com/cg/panic-disorder.html) - [Post-Traumatic Stress Disorder](https://www.drugs.com/cg/post-traumatic-stress-disorder.html) - Premenstrual dysphoric disorder Some reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen. ## What are the differences between SSRI antidepressants? Although all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example, [fluoxetine](https://www.drugs.com/fluoxetine.html), [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html), and [paroxetine](https://www.drugs.com/paroxetine.html) are more likely to interact with other medications than [citalopram](https://www.drugs.com/citalopram.html), [escitalopram](https://www.drugs.com/escitalopram.html) and [sertraline](https://www.drugs.com/sertraline.html). \| Generic name \| Brand name examples \| \|---\|---\| \| [citalopram](https://www.drugs.com/citalopram.html) \| [Celexa](https://www.drugs.com/celexa.html) \| \| [escitalopram](https://www.drugs.com/escitalopram.html) \| [Lexapro](https://www.drugs.com/lexapro.html) \| \| [fluoxetine](https://www.drugs.com/fluoxetine.html) \| [Prozac](https://www.drugs.com/prozac.html), [Sarafem](https://www.drugs.com/mtm/sarafem.html) \| \| [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html) \| [Luvox](https://www.drugs.com/mtm/luvox.html) \| \| [paroxetine](https://www.drugs.com/paroxetine.html) \| [Brisdelle](https://www.drugs.com/brisdelle.html), [Paxil](https://www.drugs.com/paxil.html), [Pexeva](https://www.drugs.com/mtm/pexeva.html) \| \| [sertraline](https://www.drugs.com/sertraline.html) \| [Zoloft](https://www.drugs.com/zoloft.html) \| \| [vilazodone](https://www.drugs.com/mtm/vilazodone.html)\* \| [Viibryd](https://www.drugs.com/viibryd.html) \| \Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS. ## Are SSRI antidepressants safe? When taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as: - An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy - [Serotonin syndrome](https://www.drugs.com/cg/serotonin-syndrome.html) – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as [dextromethorphan](https://www.drugs.com/dextromethorphan.html), [tramadol](https://www.drugs.com/tramadol.html), and [St. John's Wort](https://www.drugs.com/mtm/st-john-s-wort.html)). Symptoms include [agitation](https://www.drugs.com/condition/agitation.html), confusion, [sweating](https://www.drugs.com/condition/hyperhidrosis.html), tremors, and a rapid heart rate - An increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk. In addition, some SSRIs, such as [citalopram](https://www.drugs.com/citalopram.html) have been associated with abnormal heart rhythms with higher dosages. ## What are the side effects of SSRI antidepressants? Not everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include: - Blurred vision - Dizziness - [Drowsiness](https://www.drugs.com/condition/drowsiness.html) (fluoxetine is more likely to cause [insomnia](https://www.drugs.com/cg/insomnia.html)) - [Dry mouth](https://www.drugs.com/cg/dry-mouth.html) - Gastrointestinal upset (such as [constipation](https://www.drugs.com/cg/constipation.html), [diarrhea](https://www.drugs.com/health-guide/diarrhea.html), or [nausea](https://www.drugs.com/health-guide/nausea.html)) - [Headache](https://www.drugs.com/cg/tension-headache.html) - Sexual dysfunction (such as reduced desire or [erectile dysfunction](https://www.drugs.com/cg/erectile-dysfunction.html)). Several SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly. For a complete list of side effects, please refer to the individual drug monographs. ## List of Selective serotonin reuptake inhibitors View by: Generic* • [Brand](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=0&sort=reviews&order=desc#filterSection) Filter by \| [Drug Name](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=drug&order=asc#filterSection) \| [Avg. Rating](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=rating&order=desc#filterSection) \| [Reviews](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=reviews&order=asc#filterSection) \| \|---\|---\|---\| \| [sertraline systemic](https://www.drugs.com/sertraline.html "sertraline systemic for Consumers") ([Pro](https://www.drugs.com/monograph/sertraline.html "sertraline systemic for Health Professionals")) Brand name: [Zoloft](https://www.drugs.com/zoloft.html) \| 7\.3 \| [4,659 reviews](https://www.drugs.com/comments/sertraline/) \| \| [escitalopram systemic](https://www.drugs.com/escitalopram.html "escitalopram systemic for Consumers") ([Pro](https://www.drugs.com/monograph/escitalopram.html "escitalopram systemic for Health Professionals")) Brand name: [Lexapro](https://www.drugs.com/lexapro.html) \| 7\.5 \| [4,032 reviews](https://www.drugs.com/comments/escitalopram/) \| \| [fluoxetine systemic](https://www.drugs.com/fluoxetine.html "fluoxetine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/fluoxetine.html "fluoxetine systemic for Health Professionals")) Brand name: [Prozac](https://www.drugs.com/prozac.html) \| 7\.4 \| [2,277 reviews](https://www.drugs.com/comments/fluoxetine/) \| \| [citalopram systemic](https://www.drugs.com/citalopram.html "citalopram systemic for Consumers") ([Pro](https://www.drugs.com/monograph/citalopram.html "citalopram systemic for Health Professionals")) Brand name: [Celexa](https://www.drugs.com/celexa.html) \| 7\.4 \| [2,250 reviews](https://www.drugs.com/comments/citalopram/) \| \| [paroxetine systemic](https://www.drugs.com/paroxetine.html "paroxetine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/paroxetine.html "paroxetine systemic for Health Professionals")) Brand names: [Paxil CR](https://www.drugs.com/mtm/paxil-cr.html), [Paxil](https://www.drugs.com/paxil.html), [Brisdelle](https://www.drugs.com/brisdelle.html) \| 7\.1 \| [1,564 reviews](https://www.drugs.com/comments/paroxetine/) \| \| [fluvoxamine systemic](https://www.drugs.com/mtm/fluvoxamine.html "fluvoxamine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/fluvoxamine.html "fluvoxamine systemic for Health Professionals")) \| 6\.8 \| [391 reviews](https://www.drugs.com/comments/fluvoxamine/) \| \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| \| ## See also Medical conditions treated or associated with selective serotonin reuptake inhibitors: - [Anxiety](https://www.drugs.com/condition/anxiety.html) - [Anxiety and Stress](https://www.drugs.com/condition/anxiety-stress.html) - [Bulimia](https://www.drugs.com/condition/bulimia.html) - [Depression](https://www.drugs.com/condition/depression.html) - [Generalized Anxiety Disorder](https://www.drugs.com/condition/generalized-anxiety-disorder.html) - [Hot Flashes](https://www.drugs.com/condition/hot-flashes.html) - [Major Depressive Disorder](https://www.drugs.com/condition/major-depressive-disorder.html) - [Obsessive Compulsive Disorder](https://www.drugs.com/condition/obsessive-compulsive-disorder.html) - [Panic Disorder](https://www.drugs.com/condition/panic-disorder.html) - [Post Traumatic Stress Disorder](https://www.drugs.com/condition/post-traumatic-stress-disorder.html) - [Postmenopausal Symptoms](https://www.drugs.com/condition/postmenopausal-symptoms.html) - [Postpartum Depression](https://www.drugs.com/condition/postpartum-depression.html) - [Premature Ejaculation](https://www.drugs.com/condition/premature-ejaculation.html) - [Premenstrual Dysphoric Disorder](https://www.drugs.com/condition/premenstrual-dysphoric-disorder.html) - [Schizoaffective Disorder](https://www.drugs.com/condition/schizoaffective-disorder.html) - [Social Anxiety Disorder](https://www.drugs.com/condition/social-anxiety-disorder.html) ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 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Readable Markdown	Other names: SSRI, SSRIs ## What are SSRI drugs? SSRI stands for Selective Serotonin Reuptake Inhibitor. SSRI drugs are a type of antidepressant that have been shown to increase levels of serotonin within the brain. Serotonin is a neurotransmitter that is often referred to as the “feel good hormone”. It carries messages between brain cells and contributes to well-being, good mood, appetite, as well as helping to regulate the body’s sleep-wake cycle and internal clock. Historically, it was thought that [depression](https://www.drugs.com/cg/depression.html) was caused by low levels of serotonin and other neurotransmitters in the brain, although experts now do not think this is the case. SSRIs increase levels of serotonin in the brain by preventing the reuptake of serotonin by nerves. All SSRI drugs have this effect. Antidepressants relieve the symptoms of depression. SSRIs are one type of antidepressant. Other types include tricyclic antidepressants (TCAs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs), monoamine oxidase inhibitors (MAOIs), and the atypical antidepressants. ## What are SSRI antidepressants used for? SSRI antidepressants help to relieve symptoms of [depression](https://www.drugs.com/health-guide/depression.html) such as low mood, irritability, feelings of worthlessness, restlessness, [anxiety](https://www.drugs.com/cg/anxiety.html), and difficulty in sleeping. They are one of the most commonly prescribed antidepressants because they are effective at improving mood with fewer or less severe side effects compared to some other antidepressants. In addition to [depression](https://www.drugs.com/health-guide/depression.html), SSRIs may also be used to treat a range of other conditions, for example: - [Anxiety](https://www.drugs.com/health-guide/generalized-anxiety-disorder.html) - [Bulimia nervosa](https://www.drugs.com/cg/bulimia.html) - [Fibromyalgia](https://www.drugs.com/cg/fibromyalgia.html) - [Hot flashes](https://www.drugs.com/health-guide/hot-flashes.html) - [Obsessive-compulsive disorder](https://www.drugs.com/cg/obsessive-compulsive-disorder.html) - [Panic disorder](https://www.drugs.com/cg/panic-disorder.html) - [Post-Traumatic Stress Disorder](https://www.drugs.com/cg/post-traumatic-stress-disorder.html) - Premenstrual dysphoric disorder Some reduction in symptoms may be noticed within one to two weeks; however, it may take six to eight weeks of treatment before the full effects are seen. ## What are the differences between SSRI antidepressants? Although all SSRI antidepressants are thought to act in the same way, there are differences between individual SSRIs with regards to how long they remain in the body, how they are metabolized, and how much they interact with other medications. For example, [fluoxetine](https://www.drugs.com/fluoxetine.html), [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html), and [paroxetine](https://www.drugs.com/paroxetine.html) are more likely to interact with other medications than [citalopram](https://www.drugs.com/citalopram.html), [escitalopram](https://www.drugs.com/escitalopram.html) and [sertraline](https://www.drugs.com/sertraline.html). \| Generic name \| Brand name examples \| \|---\|---\| \| [citalopram](https://www.drugs.com/citalopram.html) \| [Celexa](https://www.drugs.com/celexa.html) \| \| [escitalopram](https://www.drugs.com/escitalopram.html) \| [Lexapro](https://www.drugs.com/lexapro.html) \| \| [fluoxetine](https://www.drugs.com/fluoxetine.html) \| [Prozac](https://www.drugs.com/prozac.html), [Sarafem](https://www.drugs.com/mtm/sarafem.html) \| \| [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html) \| [Luvox](https://www.drugs.com/mtm/luvox.html) \| \| [paroxetine](https://www.drugs.com/paroxetine.html) \| [Brisdelle](https://www.drugs.com/brisdelle.html), [Paxil](https://www.drugs.com/paxil.html), [Pexeva](https://www.drugs.com/mtm/pexeva.html) \| \| [sertraline](https://www.drugs.com/sertraline.html) \| [Zoloft](https://www.drugs.com/zoloft.html) \| \| [vilazodone](https://www.drugs.com/mtm/vilazodone.html)\* \| [Viibryd](https://www.drugs.com/viibryd.html) \| \Vilazodone is considered a serotonin modulator. Exactly how it works for depression is unknown but it does appear to potentiate serotonergic activity in the CNS. ## Are SSRI antidepressants safe? When taken at the recommended dosage, SSRI antidepressants are considered safe. However, they have been associated with a few serious, potentially fatal, severe side effects such as: - An increase in suicidal thoughts and behaviors, particularly in children and young adults under the age of 25 years. This is most likely to occur when starting therapy - [Serotonin syndrome](https://www.drugs.com/cg/serotonin-syndrome.html) – this is caused by excessive levels of serotonin in the body and is more likely to occur with higher dosages of SSRIs or when SSRIs are administered with other medications that also release serotonin (such as [dextromethorphan](https://www.drugs.com/dextromethorphan.html), [tramadol](https://www.drugs.com/tramadol.html), and [St. John's Wort](https://www.drugs.com/mtm/st-john-s-wort.html)). Symptoms include [agitation](https://www.drugs.com/condition/agitation.html), confusion, [sweating](https://www.drugs.com/condition/hyperhidrosis.html), tremors, and a rapid heart rate - An increase in the risk of bleeding, especially if used with other medications that also increase bleeding risk. In addition, some SSRIs, such as [citalopram](https://www.drugs.com/citalopram.html) have been associated with abnormal heart rhythms with higher dosages. ## What are the side effects of SSRI antidepressants? Not everybody experiences side effects with SSRIs antidepressants. Some of the more commonly reported side effects include: - Blurred vision - Dizziness - [Drowsiness](https://www.drugs.com/condition/drowsiness.html) (fluoxetine is more likely to cause [insomnia](https://www.drugs.com/cg/insomnia.html)) - [Dry mouth](https://www.drugs.com/cg/dry-mouth.html) - Gastrointestinal upset (such as [constipation](https://www.drugs.com/cg/constipation.html), [diarrhea](https://www.drugs.com/health-guide/diarrhea.html), or [nausea](https://www.drugs.com/health-guide/nausea.html)) - [Headache](https://www.drugs.com/cg/tension-headache.html) - Sexual dysfunction (such as reduced desire or [erectile dysfunction](https://www.drugs.com/cg/erectile-dysfunction.html)). Several SSRIs have been associated with a discontinuation syndrome when they have been stopped suddenly. For this reason, it is best to withdraw all antidepressants slowly. For a complete list of side effects, please refer to the individual drug monographs. ## List of Selective serotonin reuptake inhibitors View by: Generic* • [Brand](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=0&sort=reviews&order=desc#filterSection) Filter by \| [Drug Name](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=drug&order=asc#filterSection) \| [Avg. Rating](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=rating&order=desc#filterSection) \| [Reviews](https://www.drugs.com/drug-class/ssri-antidepressants.html?condition_id=0&generic=1&sort=reviews&order=asc#filterSection) \| \|---\|---\|---\| \| [sertraline systemic](https://www.drugs.com/sertraline.html "sertraline systemic for Consumers") ([Pro](https://www.drugs.com/monograph/sertraline.html "sertraline systemic for Health Professionals")) Brand name: [Zoloft](https://www.drugs.com/zoloft.html) \| 7\.3 \| [4,659 reviews](https://www.drugs.com/comments/sertraline/) \| \| [escitalopram systemic](https://www.drugs.com/escitalopram.html "escitalopram systemic for Consumers") ([Pro](https://www.drugs.com/monograph/escitalopram.html "escitalopram systemic for Health Professionals")) Brand name: [Lexapro](https://www.drugs.com/lexapro.html) \| 7\.5 \| [4,032 reviews](https://www.drugs.com/comments/escitalopram/) \| \| [fluoxetine systemic](https://www.drugs.com/fluoxetine.html "fluoxetine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/fluoxetine.html "fluoxetine systemic for Health Professionals")) Brand name: [Prozac](https://www.drugs.com/prozac.html) \| 7\.4 \| [2,277 reviews](https://www.drugs.com/comments/fluoxetine/) \| \| [citalopram systemic](https://www.drugs.com/citalopram.html "citalopram systemic for Consumers") ([Pro](https://www.drugs.com/monograph/citalopram.html "citalopram systemic for Health Professionals")) Brand name: [Celexa](https://www.drugs.com/celexa.html) \| 7\.4 \| [2,250 reviews](https://www.drugs.com/comments/citalopram/) \| \| [paroxetine systemic](https://www.drugs.com/paroxetine.html "paroxetine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/paroxetine.html "paroxetine systemic for Health Professionals")) Brand names: [Paxil CR](https://www.drugs.com/mtm/paxil-cr.html), [Paxil](https://www.drugs.com/paxil.html), [Brisdelle](https://www.drugs.com/brisdelle.html) \| 7\.1 \| [1,564 reviews](https://www.drugs.com/comments/paroxetine/) \| \| [fluvoxamine systemic](https://www.drugs.com/mtm/fluvoxamine.html "fluvoxamine systemic for Consumers") ([Pro](https://www.drugs.com/monograph/fluvoxamine.html "fluvoxamine systemic for Health Professionals")) \| 6\.8 \| [391 reviews](https://www.drugs.com/comments/fluvoxamine/) \| \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| \| ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [Medical Disclaimer](https://www.drugs.com/support/disclaimer.html)
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