🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 131 (from laksa165)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa131.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/condition/major-depressive-disorder.html\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/condition/major-depressive-disorder.html\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html","crawl_time":1775541938,"first_indexed_time":1465941867,"http_code":200,"src_unparsed":"com,drugs!www,\/condition\/major-depressive-disorder.html s443","src_root_hash":"1816286668162245731","history_drop_reason":null,"meta_title":"List of 60 Major Depressive Disorder Medications Compared","meta_descriptions":["Compare risks and benefits of common medications used for Major Depressive Disorder. Find the most popular drugs, view ratings and user reviews."],"attrs_boilerpipe_text":"Other names:\nClinical Depression; MDD; Unipolar Depression\nDrugs used  to treat Major Depressive Disorder\nThe medications listed below are related to or used in the treatment of this condition.\nSelect drug class\nBrands and Generics\nInclude off-label drugs\nRx and OTC\nDrug name\nRating\nReviews\nActivity\n�\nRx\/OTC\nPreg\nnancy\nCSA\nAlcohol\nCaplyta\nNew approval\n7.0\n6 reviews\nfor Caplyta to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\nlumateperone systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nNovember 6, 2025\nWellbutrin XL\n7.4\n131 reviews\nfor Wellbutrin XL to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nbupropion systemic\nDrug class:\nmiscellaneous antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nbupropion\n6.9\n452 reviews\nfor bupropion to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nbupropion systemic\nBrand names:\nWellbutrin XL,\nWellbutrin SR,\nAplenzin,\nBudeprion SR,\nForfivo XL\nDrug class:\nmiscellaneous antidepressants\n,\nsmoking cessation agents\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nTrintellix\n6.2\n499 reviews\nfor Trintellix to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nvortioxetine systemic\nDrug class:\nmiscellaneous antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nSeptember 30, 2013\nZoloft\n6.7\n146 reviews\nfor Zoloft to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nsertraline systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nProzac\n6.5\n105 reviews\nfor Prozac to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nfluoxetine systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nLexapro\n6.5\n122 reviews\nfor Lexapro to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nescitalopram systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nAugust 15, 2002\nRexulti\n6.6\n261 reviews\nfor Rexulti to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\nbrexpiprazole systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nJuly 10, 2015\nsertraline\n6.8\n237 reviews\nfor sertraline to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nsertraline systemic\nBrand name:\nZoloft\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nAuvelity\n8.4\n164 reviews\nfor Auvelity to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\nbupropion \/ dextromethorphan systemic\nDrug class:\npsychotherapeutic combinations\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nAugust 20, 2022\nCymbalta\n6.2\n124 reviews\nfor Cymbalta to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nduloxetine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nAugust 4, 2004\nvortioxetine\n6.3\n642 reviews\nfor vortioxetine to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nvortioxetine systemic\nBrand name:\nTrintellix\nDrug class:\nmiscellaneous antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\nVraylar\n7.0\n72 reviews\nfor Vraylar to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\ncariprazine systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nDecember 16, 2022\nAbilify\n6.1\n142 reviews\nfor Abilify to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\naripiprazole systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nNovember 6, 2007\nPristiq\n6.3\n164 reviews\nfor Pristiq to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\ndesvenlafaxine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nMarch 3, 2008\ntrazodone\n6.4\n35 reviews\nfor trazodone to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\ntrazodone systemic\nBrand name:\nRaldesy\nDrug class:\nphenylpiperazine antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nbupropion \/ dextromethorphan\n8.4\n167 reviews\nfor bupropion \/ dextromethorphan to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\nbupropion \/ dextromethorphan systemic\nBrand name:\nAuvelity\nDrug class:\npsychotherapeutic combinations\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\nEffexor XR\n6.6\n122 reviews\nfor Effexor XR to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nvenlafaxine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nbrexpiprazole\n6.5\n273 reviews\nfor brexpiprazole to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\nbrexpiprazole systemic\nBrand name:\nRexulti\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nfluoxetine\n6.7\n145 reviews\nfor fluoxetine to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nfluoxetine systemic\nBrand name:\nProzac\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nvenlafaxine\n6.5\n269 reviews\nfor venlafaxine to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nvenlafaxine systemic\nBrand names:\nEffexor XR,\nEffexor\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\ncariprazine\n7.0\n77 reviews\nfor cariprazine to treat Major Depressive Disorder\nRx\nN\n✕\nGeneric name:\ncariprazine systemic\nBrand name:\nVraylar\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\nduloxetine\n6.2\n157 reviews\nfor duloxetine to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nduloxetine systemic\nBrand names:\nCymbalta,\nIrenka\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nescitalopram\n6.6\n176 reviews\nfor escitalopram to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nescitalopram systemic\nBrand name:\nLexapro\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nmirtazapine\n7.0\n198 reviews\nfor mirtazapine to treat Major Depressive Disorder\nRx\nC\nN\n✕\nGeneric name:\nmirtazapine systemic\nBrand names:\nRemeron,\nRemeron SolTab\nDrug class:\ntetracyclic antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\n1\n2\n3\nNext\nView all\nresults on one page\nFrequently asked questions\nHow to sleep while taking Cymbalta?\nWhat is Exxua?\nHow long do venlafaxine withdrawal symptoms last?\nHow long does Zoloft (sertraline) take to work?\nWhy does Lexapro (escitalopram) cause weight gain? Complete Patient Guide\nWhen's the best time to take Lexapro (escitalopram) - Morning or Night?\nCan I stop taking Wellbutrin suddenly or should I taper off?\n8 Cymbalta Side Effects: Should I be Concerned?\nLexapro vs Zoloft: How do they compare?\nView more FAQ\nLegend\nRating\nFor ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective).\nActivity\nActivity is based on recent site visitor activity relative to other medications in the list.\nRx\nAvailable for purchase by prescription only.\nOTC\nAvailable for purchase over-the-counter.\nRx\/OTC\nAvailable for purchase by prescription or over-the-counter.\nAlcohol\nThe medication interacts with alcohol (if marked with \"✕\").\nNew approval\nThe FDA has approved this medication within the past year.\nOff-label\nThe FDA may not approve this medication for the treatment of this condition.\nEUA\nAn Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.\nExpanded access\nExpanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.\nPregnancy Category\nA\nAdequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).\nB\nAnimal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.\nC\nAnimal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.\nD\nThere is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.\n✕\nStudies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.\nN\nFDA has not classified the drug.\nControlled Substances Act (CSA) Schedule\nM\nThe drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.\nU\nCSA Schedule is unknown.\nN\nIs not subject to the Controlled Substances Act.\n1\nHas a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.\n2\nHas a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.\n3\nHas a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.\n4\nHas a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.\n5\nHas a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.\nBrowse treatment options\nA\nB\nC\nD\nE\nF\nG\nH\nI\nJ\nK\nL\nM\nN\nO\nP\nQ\nR\nS\nT\nU\nV\nW\nX\nY\nZ\nFurther information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\nMedical Disclaimer","attrs_markdown":"[Skip to main content](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html#content)\n\n[![Drugs.com - Go to homepage](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo.svg)](https:\/\/www.drugs.com\/)\n\n[Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n\nSite navigation\n\n- [**Upgrade to a Plus Plan** Remove ads and unlock more features.](https:\/\/www.drugs.com\/account\/plan\/?launch=ddc-tier-1)\n- [Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n- [Drugs A-Z](https:\/\/www.drugs.com\/drug_information.html)\n- [Pill Identifier](https:\/\/www.drugs.com\/pill_identification.html)\n- [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html)\n- [Compare Drugs](https:\/\/www.drugs.com\/compare\/)\n- [News](https:\/\/www.drugs.com\/news.html)\n- [Pro Edition](https:\/\/www.drugs.com\/professionals.html)\n- [More Resources](https:\/\/www.drugs.com\/sitemap.html)\n- [Help & Support](https:\/\/www.drugs.com\/support\/)\n\nClose\n\n1. [Home](https:\/\/www.drugs.com\/)\n2. [Treatments](https:\/\/www.drugs.com\/medical_conditions.html)\n3. [Psychiatric Disorders](https:\/\/www.drugs.com\/condition\/history-psychiatric-disorder.html)\n4. [Depression](https:\/\/www.drugs.com\/condition\/depression.html)\n5. Major Depressive Disorder\n\nPrint\n# Medications for Major Depressive Disorder\n**Other names:** Clinical Depression; MDD; Unipolar Depression\n\nSeveral types of drugs can help manage major depressive disorder, each with its strengths and weaknesses. Examples include\n\n- Selective serotonin reuptake inhibitors (SSRIs) such as [fluoxetine](https:\/\/www.drugs.com\/fluoxetine.html) ([Prozac](https:\/\/www.drugs.com\/prozac.html)), [sertraline](https:\/\/www.drugs.com\/sertraline.html) ([Zoloft](https:\/\/www.drugs.com\/zoloft.html)), [citalopram](https:\/\/www.drugs.com\/citalopram.html) ([Celexa](https:\/\/www.drugs.com\/celexa.html)), [escitalopram](https:\/\/www.drugs.com\/escitalopram.html) ([Lexapro](https:\/\/www.drugs.com\/lexapro.html))\n- Tricyclic antidepressants (TCAs) such as [amitriptyline](https:\/\/www.drugs.com\/amitriptyline.html), [imipramine](https:\/\/www.drugs.com\/mtm\/imipramine.html) ([Tofranil](https:\/\/www.drugs.com\/mtm\/tofranil.html)), [clomipramine](https:\/\/www.drugs.com\/mtm\/clomipramine.html) ([Anafranil](https:\/\/www.drugs.com\/mtm\/anafranil.html))\n- [Venlafaxine](https:\/\/www.drugs.com\/venlafaxine.html) ([Effexor](https:\/\/www.drugs.com\/effexor.html))\n- [Duloxetine](https:\/\/www.drugs.com\/duloxetine.html) ([Cymbalta](https:\/\/www.drugs.com\/cymbalta.html))\n- Cognitive behavioral therapy\n- Interpersonal therapy\n- Problem-solving therapy\n- Monoamine oxidase inhibitors (MAOIs) such as [phenelzine](https:\/\/www.drugs.com\/mtm\/phenelzine.html) ([Nardil](https:\/\/www.drugs.com\/mtm\/nardil.html)), [tranylcypromine](https:\/\/www.drugs.com\/mtm\/tranylcypromine.html) ([Parnate](https:\/\/www.drugs.com\/mtm\/parnate.html)), or [isocarboxazid](https:\/\/www.drugs.com\/mtm\/isocarboxazid.html) ([Marplan](https:\/\/www.drugs.com\/mtm\/marplan.html)) may also be used when other treatments have been ineffective.\n## Drugs used to treat Major Depressive Disorder\nThe medications listed below are related to or used in the treatment of this condition.\n\n| [Drug name](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=drug&order=asc) | [Rating](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=rating&order=desc) | [Reviews](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=reviews&order=desc) | [Activity](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=popularity&order=asc)  [�](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html#medication-table-activity) | Rx\/OTC | Pregnancy | CSA | Alcohol |\n|---|---|---|---|---|---|---|---|\n| Expand current row for information about Caplyta [Caplyta](https:\/\/www.drugs.com\/caplyta.html) New approval |   |   |   |   |   |   |   |\n\n- 1\n- [2](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=2)\n- [3](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=3)\n- [**Next**](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=2)\n- [View all results on one page](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_all=1)\n## Frequently asked questions\n- [How to sleep while taking Cymbalta?](https:\/\/www.drugs.com\/medical-answers\/sleep-taking-cymbalta-3565234\/)\n- [What is Exxua?](https:\/\/www.drugs.com\/medical-answers\/what-exxua-3574145\/)\n- [How long do venlafaxine withdrawal symptoms last?](https:\/\/www.drugs.com\/medical-answers\/long-venlafaxine-withdrawal-symptoms-3573466\/)\n- [How long does Zoloft (sertraline) take to work?](https:\/\/www.drugs.com\/medical-answers\/long-zoloft-sertraline-work-3565128\/)\n- [Why does Lexapro (escitalopram) cause weight gain? Complete Patient Guide](https:\/\/www.drugs.com\/medical-answers\/lexapro-weight-gain-3571754\/)\n- [When's the best time to take Lexapro (escitalopram) - Morning or Night?](https:\/\/www.drugs.com\/medical-answers\/best-time-lexapro-3571761\/)\n- [Can I stop taking Wellbutrin suddenly or should I taper off?](https:\/\/www.drugs.com\/medical-answers\/stop-taking-wellbutrin-suddenly-taper-3574885\/)\n- [8 Cymbalta Side Effects: Should I be Concerned?](https:\/\/www.drugs.com\/medical-answers\/8-cymbalta-side-effects-concerned-3573726\/)\n- [Lexapro vs Zoloft: How do they compare?](https:\/\/www.drugs.com\/medical-answers\/difference-between-lexapro-zoloft-3507675\/)\n\n[View more FAQ](https:\/\/www.drugs.com\/answers\/support-group\/major-depressive-disorder\/questions\/?status=faq)\n\n## Learn more about Major Depressive Disorder\n- [What is a Boxed Warning?](https:\/\/www.drugs.com\/article\/what-are-boxed-warnings.html)\n#### Care guides\n- [Depression](https:\/\/www.drugs.com\/cg\/depression.html)\n- [Depression in Children](https:\/\/www.drugs.com\/cg\/depression-in-children.html)\n- [Seasonal Affective Disorder](https:\/\/www.drugs.com\/cg\/seasonal-affective-disorder.html)\n\n#### Legend\n|   |   |\n|---|---|\n| Rating | For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |\n| Activity | Activity is based on recent site visitor activity relative to other medications in the list. |\n| Rx | Available for purchase by prescription only. |\n| OTC | Available for purchase over-the-counter. |\n| Rx\/OTC | Available for purchase by prescription or over-the-counter. |\n| Alcohol | The medication interacts with alcohol (if marked with \"✕\"). |\n| New approval | The FDA has approved this medication within the past year. |\n| Off-label | The FDA may not approve this medication for the treatment of this condition. |\n| EUA | An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. |\n| Expanded access | Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. |\n\n| Pregnancy Category |   |\n|---|---|\n| A | Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). |\n| B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. |\n| C | Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| ✕ | Studies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. |\n| N | FDA has not classified the drug. |\n\n| Controlled Substances Act (CSA) Schedule |   |\n|---|---|\n| M | The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. |\n| U | CSA Schedule is unknown. |\n| N | Is not subject to the Controlled Substances Act. |\n| 1 | Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |\n| 2 | Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |\n| 3 | Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |\n| 4 | Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |\n| 5 | Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |\n\n### Browse treatment options\n- [A](https:\/\/www.drugs.com\/condition\/a.html)\n- [B](https:\/\/www.drugs.com\/condition\/b.html)\n- [C](https:\/\/www.drugs.com\/condition\/c.html)\n- [D](https:\/\/www.drugs.com\/condition\/d.html)\n- [E](https:\/\/www.drugs.com\/condition\/e.html)\n- [F](https:\/\/www.drugs.com\/condition\/f.html)\n- [G](https:\/\/www.drugs.com\/condition\/g.html)\n- [H](https:\/\/www.drugs.com\/condition\/h.html)\n- [I](https:\/\/www.drugs.com\/condition\/i.html)\n- [J](https:\/\/www.drugs.com\/condition\/j.html)\n- [K](https:\/\/www.drugs.com\/condition\/k.html)\n- [L](https:\/\/www.drugs.com\/condition\/l.html)\n- [M](https:\/\/www.drugs.com\/condition\/m.html)\n- [N](https:\/\/www.drugs.com\/condition\/n.html)\n- [O](https:\/\/www.drugs.com\/condition\/o.html)\n- [P](https:\/\/www.drugs.com\/condition\/p.html)\n- [Q](https:\/\/www.drugs.com\/condition\/q.html)\n- [R](https:\/\/www.drugs.com\/condition\/r.html)\n- [S](https:\/\/www.drugs.com\/condition\/s.html)\n- [T](https:\/\/www.drugs.com\/condition\/t.html)\n- [U](https:\/\/www.drugs.com\/condition\/u.html)\n- [V](https:\/\/www.drugs.com\/condition\/v.html)\n- [W](https:\/\/www.drugs.com\/condition\/w.html)\n- [X](https:\/\/www.drugs.com\/condition\/x.html)\n- [Y](https:\/\/www.drugs.com\/condition\/y.html)\n- [Z](https:\/\/www.drugs.com\/condition\/z.html)\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)\n\nLatest FDA Approvals for Major Depressive Disorder\n\n- [Exxua](https:\/\/www.drugs.com\/newdrugs\/fda-approves-exxua-gepirone-major-depressive-disorder-adults-6102.html)\n- [Auvelity](https:\/\/www.drugs.com\/newdrugs\/fda-approves-auvelity-dextromethorphan-bupropion-major-depressive-disorder-adults-5879.html)\n- [Caplyta](https:\/\/www.drugs.com\/newdrugs\/intra-cellular-therapies-announces-fda-approval-new-caplyta-lumateperone-specific-patient-5822.html)\n\n**Drugs.com Mobile App**\n\nAccess drug & treatment information, identify pills, check interactions and set up personal medication records.\n\n[Download the Medication Guide app on iTunes ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/apple-store.png)](https:\/\/apps.apple.com\/us\/app\/drugs-com-medication-guide\/id599471042?platform=iphone)   [Download the Medication Guide app on the Google Play store ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/google-play.png)](https:\/\/play.google.com\/store\/apps\/details?id=com.drugscom.app)\n\n![Drugs.com mobile app](https:\/\/www.drugs.com\/img\/v-20250709\/apps\/promo-uberapp.png)\n\n[Drugs.com ![](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo-mark.svg)](https:\/\/www.drugs.com\/)\n\n**About**\n\n- [About Drugs.com](https:\/\/www.drugs.com\/support\/about.html)\n- [Advertising policy](https:\/\/www.drugs.com\/support\/advertising.html)\n- [Attribution & citations](https:\/\/www.drugs.com\/support\/citations.html)\n- [Drugs.com Podcast](https:\/\/podcasts.drugs.com\/)\n\n**Terms & privacy**\n\n- [Terms of use](https:\/\/www.drugs.com\/support\/terms.html)\n- [Editorial policy](https:\/\/www.drugs.com\/support\/editorial-policy.html)\n- [Privacy policy](https:\/\/www.drugs.com\/support\/privacy.html)\n- [Privacy settings](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html)\n\n**Support**\n\n- [Help center](https:\/\/www.drugs.com\/support\/)\n- [Sitemap](https:\/\/www.drugs.com\/sitemap.html)\n- [Contact us](https:\/\/www.drugs.com\/support\/contact.html)\n- [Accessibility](https:\/\/www.drugs.com\/support\/accessibility.html)\n\n- [Subscribe to Drugs.com newsletters](https:\/\/www.drugs.com\/newsletters\/)\n- [Follow Drugs.com on Facebook](https:\/\/www.facebook.com\/Drugscom)\n- [Follow Drugs.com on X (Twitter)](https:\/\/x.com\/drugscom)\n- [Follow Drugs.com on Instagram](https:\/\/www.instagram.com\/drugs.com_official\/)\n- [Follow Drugs.com on YouTube](https:\/\/www.youtube.com\/user\/drugscom)\n- [Follow Drugs.com on Pinterest](https:\/\/www.pinterest.com\/drugscom\/)\n\n[Subscribe to our newsletter](https:\/\/www.drugs.com\/newsletters\/) for the latest medication news, new drug approvals and FDA alerts.\n\n**Drugs.com** provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Mar 31, 2026), Cerner Multum™ (updated Mar 29, 2026), ASHP (updated Mar 10, 2026) and others.\n\n[![Certified by TRUSTe](https:\/\/privacy-policy.truste.com\/privacy-seal\/seal?rid=d18cba4a-afc4-4863-af81-8262bb120271)](https:\/\/privacy.truste.com\/privacy-seal\/validation?rid=d18cba4a-afc4-4863-af81-8262bb120271)  ![Verified by TAG](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/tag-verified.png)  [![This website is certified by AACI. Click to verify.](https:\/\/www.drugs.com\/img\/v-20251028\/logo\/vendor\/trust-mark-logo.png)](https:\/\/aacihealthcare.com\/certificates\/c173-2022-trust-us\/)   [![AdChoices - Ad privacy information](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/adchoices-logomark.png)](https:\/\/www.drugs.com\/support\/privacy\/advertising.html)\n\nCopyright © 2000-2026 Drugs.com. All rights reserved.","attrs_readable_markdown":"**Other names:** Clinical Depression; MDD; Unipolar Depression\n\n## Drugs used to treat Major Depressive Disorder\nThe medications listed below are related to or used in the treatment of this condition.\n\n| [Drug name](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=drug&order=asc) | [Rating](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=rating&order=desc) | [Reviews](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=reviews&order=desc) | [Activity](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?sort=popularity&order=asc)  [�](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html#medication-table-activity) | Rx\/OTC | Pregnancy | CSA | Alcohol |\n|---|---|---|---|---|---|---|---|\n| [Caplyta](https:\/\/www.drugs.com\/caplyta.html) New approval |   |   |   |   |   |   |   |\n\n- 1\n- [2](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=2)\n- [3](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=3)\n- [**Next**](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_number=2)\n- [View all results on one page](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html?page_all=1)\n## Frequently asked questions\n- [How to sleep while taking Cymbalta?](https:\/\/www.drugs.com\/medical-answers\/sleep-taking-cymbalta-3565234\/)\n- [What is Exxua?](https:\/\/www.drugs.com\/medical-answers\/what-exxua-3574145\/)\n- [How long do venlafaxine withdrawal symptoms last?](https:\/\/www.drugs.com\/medical-answers\/long-venlafaxine-withdrawal-symptoms-3573466\/)\n- [How long does Zoloft (sertraline) take to work?](https:\/\/www.drugs.com\/medical-answers\/long-zoloft-sertraline-work-3565128\/)\n- [Why does Lexapro (escitalopram) cause weight gain? Complete Patient Guide](https:\/\/www.drugs.com\/medical-answers\/lexapro-weight-gain-3571754\/)\n- [When's the best time to take Lexapro (escitalopram) - Morning or Night?](https:\/\/www.drugs.com\/medical-answers\/best-time-lexapro-3571761\/)\n- [Can I stop taking Wellbutrin suddenly or should I taper off?](https:\/\/www.drugs.com\/medical-answers\/stop-taking-wellbutrin-suddenly-taper-3574885\/)\n- [8 Cymbalta Side Effects: Should I be Concerned?](https:\/\/www.drugs.com\/medical-answers\/8-cymbalta-side-effects-concerned-3573726\/)\n- [Lexapro vs Zoloft: How do they compare?](https:\/\/www.drugs.com\/medical-answers\/difference-between-lexapro-zoloft-3507675\/)\n\n[View more FAQ](https:\/\/www.drugs.com\/answers\/support-group\/major-depressive-disorder\/questions\/?status=faq)\n\n#### Legend\n|   |   |\n|---|---|\n| Rating | For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |\n| Activity | Activity is based on recent site visitor activity relative to other medications in the list. |\n| Rx | Available for purchase by prescription only. |\n| OTC | Available for purchase over-the-counter. |\n| Rx\/OTC | Available for purchase by prescription or over-the-counter. |\n| Alcohol | The medication interacts with alcohol (if marked with \"✕\"). |\n| New approval | The FDA has approved this medication within the past year. |\n| Off-label | The FDA may not approve this medication for the treatment of this condition. |\n| EUA | An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. |\n| Expanded access | Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. |\n\n| Pregnancy Category |   |\n|---|---|\n| A | Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). |\n| B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. |\n| C | Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| ✕ | Studies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. |\n| N | FDA has not classified the drug. |\n\n| Controlled Substances Act (CSA) Schedule |   |\n|---|---|\n| M | The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. |\n| U | CSA Schedule is unknown. |\n| N | Is not subject to the Controlled Substances Act. |\n| 1 | Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |\n| 2 | Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |\n| 3 | Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |\n| 4 | Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |\n| 5 | Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |\n\n### Browse treatment options\n- [A](https:\/\/www.drugs.com\/condition\/a.html)\n- [B](https:\/\/www.drugs.com\/condition\/b.html)\n- [C](https:\/\/www.drugs.com\/condition\/c.html)\n- [D](https:\/\/www.drugs.com\/condition\/d.html)\n- [E](https:\/\/www.drugs.com\/condition\/e.html)\n- [F](https:\/\/www.drugs.com\/condition\/f.html)\n- [G](https:\/\/www.drugs.com\/condition\/g.html)\n- [H](https:\/\/www.drugs.com\/condition\/h.html)\n- [I](https:\/\/www.drugs.com\/condition\/i.html)\n- [J](https:\/\/www.drugs.com\/condition\/j.html)\n- [K](https:\/\/www.drugs.com\/condition\/k.html)\n- [L](https:\/\/www.drugs.com\/condition\/l.html)\n- [M](https:\/\/www.drugs.com\/condition\/m.html)\n- [N](https:\/\/www.drugs.com\/condition\/n.html)\n- [O](https:\/\/www.drugs.com\/condition\/o.html)\n- [P](https:\/\/www.drugs.com\/condition\/p.html)\n- [Q](https:\/\/www.drugs.com\/condition\/q.html)\n- [R](https:\/\/www.drugs.com\/condition\/r.html)\n- [S](https:\/\/www.drugs.com\/condition\/s.html)\n- [T](https:\/\/www.drugs.com\/condition\/t.html)\n- [U](https:\/\/www.drugs.com\/condition\/u.html)\n- [V](https:\/\/www.drugs.com\/condition\/v.html)\n- [W](https:\/\/www.drugs.com\/condition\/w.html)\n- [X](https:\/\/www.drugs.com\/condition\/x.html)\n- [Y](https:\/\/www.drugs.com\/condition\/y.html)\n- [Z](https:\/\/www.drugs.com\/condition\/z.html)\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)","meta_canonical":null}

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URL	https://www.drugs.com/condition/major-depressive-disorder.html
Last Crawled	2026-04-07 06:05:38 (4 days ago)
First Indexed	2016-06-14 22:04:27 (9 years ago)
HTTP Status Code	200
Meta Title	List of 60 Major Depressive Disorder Medications Compared
Meta Description	Compare risks and benefits of common medications used for Major Depressive Disorder. Find the most popular drugs, view ratings and user reviews.
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Boilerpipe Text	Other names: Clinical Depression; MDD; Unipolar Depression Drugs used to treat Major Depressive Disorder The medications listed below are related to or used in the treatment of this condition. Select drug class Brands and Generics Include off-label drugs Rx and OTC Drug name Rating Reviews Activity � Rx/OTC Preg nancy CSA Alcohol Caplyta New approval 7.0 6 reviews for Caplyta to treat Major Depressive Disorder Rx N ✕ Generic name: lumateperone systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: November 6, 2025 Wellbutrin XL 7.4 131 reviews for Wellbutrin XL to treat Major Depressive Disorder Rx C N ✕ Generic name: bupropion systemic Drug class: miscellaneous antidepressants For consumers: dosage , interactions , side effects For professionals: Prescribing Information bupropion 6.9 452 reviews for bupropion to treat Major Depressive Disorder Rx C N ✕ Generic name: bupropion systemic Brand names: Wellbutrin XL, Wellbutrin SR, Aplenzin, Budeprion SR, Forfivo XL Drug class: miscellaneous antidepressants , smoking cessation agents For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Trintellix 6.2 499 reviews for Trintellix to treat Major Depressive Disorder Rx C N ✕ Generic name: vortioxetine systemic Drug class: miscellaneous antidepressants For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: September 30, 2013 Zoloft 6.7 146 reviews for Zoloft to treat Major Depressive Disorder Rx C N ✕ Generic name: sertraline systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information Prozac 6.5 105 reviews for Prozac to treat Major Depressive Disorder Rx C N ✕ Generic name: fluoxetine systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information Lexapro 6.5 122 reviews for Lexapro to treat Major Depressive Disorder Rx C N ✕ Generic name: escitalopram systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: August 15, 2002 Rexulti 6.6 261 reviews for Rexulti to treat Major Depressive Disorder Rx N ✕ Generic name: brexpiprazole systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: July 10, 2015 sertraline 6.8 237 reviews for sertraline to treat Major Depressive Disorder Rx C N ✕ Generic name: sertraline systemic Brand name: Zoloft Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Auvelity 8.4 164 reviews for Auvelity to treat Major Depressive Disorder Rx N ✕ Generic name: bupropion / dextromethorphan systemic Drug class: psychotherapeutic combinations For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: August 20, 2022 Cymbalta 6.2 124 reviews for Cymbalta to treat Major Depressive Disorder Rx C N ✕ Generic name: duloxetine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: August 4, 2004 vortioxetine 6.3 642 reviews for vortioxetine to treat Major Depressive Disorder Rx C N ✕ Generic name: vortioxetine systemic Brand name: Trintellix Drug class: miscellaneous antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph Vraylar 7.0 72 reviews for Vraylar to treat Major Depressive Disorder Rx N ✕ Generic name: cariprazine systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: December 16, 2022 Abilify 6.1 142 reviews for Abilify to treat Major Depressive Disorder Rx C N ✕ Generic name: aripiprazole systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: November 6, 2007 Pristiq 6.3 164 reviews for Pristiq to treat Major Depressive Disorder Rx C N ✕ Generic name: desvenlafaxine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: March 3, 2008 trazodone 6.4 35 reviews for trazodone to treat Major Depressive Disorder Rx C N ✕ Generic name: trazodone systemic Brand name: Raldesy Drug class: phenylpiperazine antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information bupropion / dextromethorphan 8.4 167 reviews for bupropion / dextromethorphan to treat Major Depressive Disorder Rx N ✕ Generic name: bupropion / dextromethorphan systemic Brand name: Auvelity Drug class: psychotherapeutic combinations For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph Effexor XR 6.6 122 reviews for Effexor XR to treat Major Depressive Disorder Rx C N ✕ Generic name: venlafaxine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information brexpiprazole 6.5 273 reviews for brexpiprazole to treat Major Depressive Disorder Rx N ✕ Generic name: brexpiprazole systemic Brand name: Rexulti Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information fluoxetine 6.7 145 reviews for fluoxetine to treat Major Depressive Disorder Rx C N ✕ Generic name: fluoxetine systemic Brand name: Prozac Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information venlafaxine 6.5 269 reviews for venlafaxine to treat Major Depressive Disorder Rx C N ✕ Generic name: venlafaxine systemic Brand names: Effexor XR, Effexor Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information cariprazine 7.0 77 reviews for cariprazine to treat Major Depressive Disorder Rx N ✕ Generic name: cariprazine systemic Brand name: Vraylar Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph duloxetine 6.2 157 reviews for duloxetine to treat Major Depressive Disorder Rx C N ✕ Generic name: duloxetine systemic Brand names: Cymbalta, Irenka Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information escitalopram 6.6 176 reviews for escitalopram to treat Major Depressive Disorder Rx C N ✕ Generic name: escitalopram systemic Brand name: Lexapro Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information mirtazapine 7.0 198 reviews for mirtazapine to treat Major Depressive Disorder Rx C N ✕ Generic name: mirtazapine systemic Brand names: Remeron, Remeron SolTab Drug class: tetracyclic antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information 1 2 3 Next View all results on one page Frequently asked questions How to sleep while taking Cymbalta? What is Exxua? How long do venlafaxine withdrawal symptoms last? How long does Zoloft (sertraline) take to work? Why does Lexapro (escitalopram) cause weight gain? Complete Patient Guide When's the best time to take Lexapro (escitalopram) - Morning or Night? Can I stop taking Wellbutrin suddenly or should I taper off? 8 Cymbalta Side Effects: Should I be Concerned? Lexapro vs Zoloft: How do they compare? View more FAQ Legend Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Activity Activity is based on recent site visitor activity relative to other medications in the list. Rx Available for purchase by prescription only. OTC Available for purchase over-the-counter. Rx/OTC Available for purchase by prescription or over-the-counter. Alcohol The medication interacts with alcohol (if marked with "✕"). New approval The FDA has approved this medication within the past year. Off-label The FDA may not approve this medication for the treatment of this condition. EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. Expanded access Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. Pregnancy Category A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. ✕ Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. N FDA has not classified the drug. Controlled Substances Act (CSA) Schedule M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. U CSA Schedule is unknown. N Is not subject to the Controlled Substances Act. 1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. 2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. 3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. 4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. 5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. Browse treatment options A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Medical Disclaimer
Markdown	[Skip to main content](https://www.drugs.com/condition/major-depressive-disorder.html#content) [![Drugs.com - Go to homepage](https://www.drugs.com/img/logo/drugscom-logo.svg)](https://www.drugs.com/) [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) Site navigation - [Upgrade to a Plus Plan Remove ads and unlock more features.](https://www.drugs.com/account/plan/?launch=ddc-tier-1) - [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) - [Drugs A-Z](https://www.drugs.com/drug_information.html) - [Pill Identifier](https://www.drugs.com/pill_identification.html) - [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html) - [Compare Drugs](https://www.drugs.com/compare/) - [News](https://www.drugs.com/news.html) - [Pro Edition](https://www.drugs.com/professionals.html) - [More Resources](https://www.drugs.com/sitemap.html) - [Help & Support](https://www.drugs.com/support/) Close 1. [Home](https://www.drugs.com/) 2. [Treatments](https://www.drugs.com/medical_conditions.html) 3. [Psychiatric Disorders](https://www.drugs.com/condition/history-psychiatric-disorder.html) 4. [Depression](https://www.drugs.com/condition/depression.html) 5. Major Depressive Disorder Print # Medications for Major Depressive Disorder Other names: Clinical Depression; MDD; Unipolar Depression Several types of drugs can help manage major depressive disorder, each with its strengths and weaknesses. Examples include - Selective serotonin reuptake inhibitors (SSRIs) such as [fluoxetine](https://www.drugs.com/fluoxetine.html) ([Prozac](https://www.drugs.com/prozac.html)), [sertraline](https://www.drugs.com/sertraline.html) ([Zoloft](https://www.drugs.com/zoloft.html)), [citalopram](https://www.drugs.com/citalopram.html) ([Celexa](https://www.drugs.com/celexa.html)), [escitalopram](https://www.drugs.com/escitalopram.html) ([Lexapro](https://www.drugs.com/lexapro.html)) - Tricyclic antidepressants (TCAs) such as [amitriptyline](https://www.drugs.com/amitriptyline.html), [imipramine](https://www.drugs.com/mtm/imipramine.html) ([Tofranil](https://www.drugs.com/mtm/tofranil.html)), [clomipramine](https://www.drugs.com/mtm/clomipramine.html) ([Anafranil](https://www.drugs.com/mtm/anafranil.html)) - [Venlafaxine](https://www.drugs.com/venlafaxine.html) ([Effexor](https://www.drugs.com/effexor.html)) - [Duloxetine](https://www.drugs.com/duloxetine.html) ([Cymbalta](https://www.drugs.com/cymbalta.html)) - Cognitive behavioral therapy - Interpersonal therapy - Problem-solving therapy - Monoamine oxidase inhibitors (MAOIs) such as [phenelzine](https://www.drugs.com/mtm/phenelzine.html) ([Nardil](https://www.drugs.com/mtm/nardil.html)), [tranylcypromine](https://www.drugs.com/mtm/tranylcypromine.html) ([Parnate](https://www.drugs.com/mtm/parnate.html)), or [isocarboxazid](https://www.drugs.com/mtm/isocarboxazid.html) ([Marplan](https://www.drugs.com/mtm/marplan.html)) may also be used when other treatments have been ineffective. ## Drugs used to treat Major Depressive Disorder The medications listed below are related to or used in the treatment of this condition. \| [Drug name](https://www.drugs.com/condition/major-depressive-disorder.html?sort=drug&order=asc) \| [Rating](https://www.drugs.com/condition/major-depressive-disorder.html?sort=rating&order=desc) \| [Reviews](https://www.drugs.com/condition/major-depressive-disorder.html?sort=reviews&order=desc) \| [Activity](https://www.drugs.com/condition/major-depressive-disorder.html?sort=popularity&order=asc) [�](https://www.drugs.com/condition/major-depressive-disorder.html#medication-table-activity) \| Rx/OTC \| Pregnancy \| CSA \| Alcohol \| \|---\|---\|---\|---\|---\|---\|---\|---\| \| Expand current row for information about Caplyta [Caplyta](https://www.drugs.com/caplyta.html) New approval \| \| \| \| \| \| \| \| - 1 - [2](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=2) - [3](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=3) - [Next](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=2) - [View all results on one page](https://www.drugs.com/condition/major-depressive-disorder.html?page_all=1) ## Frequently asked questions - [How to sleep while taking Cymbalta?](https://www.drugs.com/medical-answers/sleep-taking-cymbalta-3565234/) - [What is Exxua?](https://www.drugs.com/medical-answers/what-exxua-3574145/) - [How long do venlafaxine withdrawal symptoms last?](https://www.drugs.com/medical-answers/long-venlafaxine-withdrawal-symptoms-3573466/) - [How long does Zoloft (sertraline) take to work?](https://www.drugs.com/medical-answers/long-zoloft-sertraline-work-3565128/) - [Why does Lexapro (escitalopram) cause weight gain? Complete Patient Guide](https://www.drugs.com/medical-answers/lexapro-weight-gain-3571754/) - [When's the best time to take Lexapro (escitalopram) - Morning or Night?](https://www.drugs.com/medical-answers/best-time-lexapro-3571761/) - [Can I stop taking Wellbutrin suddenly or should I taper off?](https://www.drugs.com/medical-answers/stop-taking-wellbutrin-suddenly-taper-3574885/) - [8 Cymbalta Side Effects: Should I be Concerned?](https://www.drugs.com/medical-answers/8-cymbalta-side-effects-concerned-3573726/) - [Lexapro vs Zoloft: How do they compare?](https://www.drugs.com/medical-answers/difference-between-lexapro-zoloft-3507675/) [View more FAQ](https://www.drugs.com/answers/support-group/major-depressive-disorder/questions/?status=faq) ## Learn more about Major Depressive Disorder - [What is a Boxed Warning?](https://www.drugs.com/article/what-are-boxed-warnings.html) #### Care guides - [Depression](https://www.drugs.com/cg/depression.html) - [Depression in Children](https://www.drugs.com/cg/depression-in-children.html) - [Seasonal Affective Disorder](https://www.drugs.com/cg/seasonal-affective-disorder.html) #### Legend \| \| \| \|---\|---\| \| Rating \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| Activity \| Activity is based on recent site visitor activity relative to other medications in the list. \| \| Rx \| Available for purchase by prescription only. \| \| OTC \| Available for purchase over-the-counter. \| \| Rx/OTC \| Available for purchase by prescription or over-the-counter. \| \| Alcohol \| The medication interacts with alcohol (if marked with "✕"). \| \| New approval \| The FDA has approved this medication within the past year. \| \| Off-label \| The FDA may not approve this medication for the treatment of this condition. \| \| EUA \| An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. \| \| Expanded access \| Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. \| \| Pregnancy Category \| \| \|---\|---\| \| A \| Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). \| \| B \| Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. \| \| C \| Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| D \| There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| ✕ \| Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. \| \| N \| FDA has not classified the drug. \| \| Controlled Substances Act (CSA) Schedule \| \| \|---\|---\| \| M \| The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. \| \| U \| CSA Schedule is unknown. \| \| N \| Is not subject to the Controlled Substances Act. \| \| 1 \| Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. \| \| 2 \| Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. \| \| 3 \| Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. \| \| 4 \| Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. \| \| 5 \| Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. \| ### Browse treatment options - [A](https://www.drugs.com/condition/a.html) - [B](https://www.drugs.com/condition/b.html) - [C](https://www.drugs.com/condition/c.html) - [D](https://www.drugs.com/condition/d.html) - [E](https://www.drugs.com/condition/e.html) - [F](https://www.drugs.com/condition/f.html) - [G](https://www.drugs.com/condition/g.html) - [H](https://www.drugs.com/condition/h.html) - [I](https://www.drugs.com/condition/i.html) - [J](https://www.drugs.com/condition/j.html) - [K](https://www.drugs.com/condition/k.html) - [L](https://www.drugs.com/condition/l.html) - [M](https://www.drugs.com/condition/m.html) - [N](https://www.drugs.com/condition/n.html) - [O](https://www.drugs.com/condition/o.html) - [P](https://www.drugs.com/condition/p.html) - [Q](https://www.drugs.com/condition/q.html) - [R](https://www.drugs.com/condition/r.html) - [S](https://www.drugs.com/condition/s.html) - [T](https://www.drugs.com/condition/t.html) - [U](https://www.drugs.com/condition/u.html) - [V](https://www.drugs.com/condition/v.html) - [W](https://www.drugs.com/condition/w.html) - [X](https://www.drugs.com/condition/x.html) - [Y](https://www.drugs.com/condition/y.html) - [Z](https://www.drugs.com/condition/z.html) ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [Medical Disclaimer](https://www.drugs.com/support/disclaimer.html) Latest FDA Approvals for Major Depressive Disorder - [Exxua](https://www.drugs.com/newdrugs/fda-approves-exxua-gepirone-major-depressive-disorder-adults-6102.html) - [Auvelity](https://www.drugs.com/newdrugs/fda-approves-auvelity-dextromethorphan-bupropion-major-depressive-disorder-adults-5879.html) - [Caplyta](https://www.drugs.com/newdrugs/intra-cellular-therapies-announces-fda-approval-new-caplyta-lumateperone-specific-patient-5822.html) Drugs.com Mobile App Access drug & treatment information, identify pills, check interactions and set up personal medication records. 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Readable Markdown	Other names: Clinical Depression; MDD; Unipolar Depression ## Drugs used to treat Major Depressive Disorder The medications listed below are related to or used in the treatment of this condition. \| [Drug name](https://www.drugs.com/condition/major-depressive-disorder.html?sort=drug&order=asc) \| [Rating](https://www.drugs.com/condition/major-depressive-disorder.html?sort=rating&order=desc) \| [Reviews](https://www.drugs.com/condition/major-depressive-disorder.html?sort=reviews&order=desc) \| [Activity](https://www.drugs.com/condition/major-depressive-disorder.html?sort=popularity&order=asc) [�](https://www.drugs.com/condition/major-depressive-disorder.html#medication-table-activity) \| Rx/OTC \| Pregnancy \| CSA \| Alcohol \| \|---\|---\|---\|---\|---\|---\|---\|---\| \| [Caplyta](https://www.drugs.com/caplyta.html) New approval \| \| \| \| \| \| \| \| - 1 - [2](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=2) - [3](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=3) - [Next](https://www.drugs.com/condition/major-depressive-disorder.html?page_number=2) - [View all results on one page](https://www.drugs.com/condition/major-depressive-disorder.html?page_all=1) ## Frequently asked questions - [How to sleep while taking Cymbalta?](https://www.drugs.com/medical-answers/sleep-taking-cymbalta-3565234/) - [What is Exxua?](https://www.drugs.com/medical-answers/what-exxua-3574145/) - [How long do venlafaxine withdrawal symptoms last?](https://www.drugs.com/medical-answers/long-venlafaxine-withdrawal-symptoms-3573466/) - [How long does Zoloft (sertraline) take to work?](https://www.drugs.com/medical-answers/long-zoloft-sertraline-work-3565128/) - [Why does Lexapro (escitalopram) cause weight gain? Complete Patient Guide](https://www.drugs.com/medical-answers/lexapro-weight-gain-3571754/) - [When's the best time to take Lexapro (escitalopram) - Morning or Night?](https://www.drugs.com/medical-answers/best-time-lexapro-3571761/) - [Can I stop taking Wellbutrin suddenly or should I taper off?](https://www.drugs.com/medical-answers/stop-taking-wellbutrin-suddenly-taper-3574885/) - [8 Cymbalta Side Effects: Should I be Concerned?](https://www.drugs.com/medical-answers/8-cymbalta-side-effects-concerned-3573726/) - [Lexapro vs Zoloft: How do they compare?](https://www.drugs.com/medical-answers/difference-between-lexapro-zoloft-3507675/) [View more FAQ](https://www.drugs.com/answers/support-group/major-depressive-disorder/questions/?status=faq) #### Legend \| \| \| \|---\|---\| \| Rating \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| Activity \| Activity is based on recent site visitor activity relative to other medications in the list. \| \| Rx \| Available for purchase by prescription only. \| \| OTC \| Available for purchase over-the-counter. \| \| Rx/OTC \| Available for purchase by prescription or over-the-counter. \| \| Alcohol \| The medication interacts with alcohol (if marked with "✕"). \| \| New approval \| The FDA has approved this medication within the past year. \| \| Off-label \| The FDA may not approve this medication for the treatment of this condition. \| \| EUA \| An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. \| \| Expanded access \| Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. \| \| Pregnancy Category \| \| \|---\|---\| \| A \| Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). \| \| B \| Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. \| \| C \| Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| D \| There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| ✕ \| Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. \| \| N \| FDA has not classified the drug. \| \| Controlled Substances Act (CSA) Schedule \| \| \|---\|---\| \| M \| The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. \| \| U \| CSA Schedule is unknown. \| \| N \| Is not subject to the Controlled Substances Act. \| \| 1 \| Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. \| \| 2 \| Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. \| \| 3 \| Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. \| \| 4 \| Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. \| \| 5 \| Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. \| ### Browse treatment options - [A](https://www.drugs.com/condition/a.html) - [B](https://www.drugs.com/condition/b.html) - [C](https://www.drugs.com/condition/c.html) - [D](https://www.drugs.com/condition/d.html) - [E](https://www.drugs.com/condition/e.html) - [F](https://www.drugs.com/condition/f.html) - [G](https://www.drugs.com/condition/g.html) - [H](https://www.drugs.com/condition/h.html) - [I](https://www.drugs.com/condition/i.html) - [J](https://www.drugs.com/condition/j.html) - [K](https://www.drugs.com/condition/k.html) - [L](https://www.drugs.com/condition/l.html) - [M](https://www.drugs.com/condition/m.html) - [N](https://www.drugs.com/condition/n.html) - [O](https://www.drugs.com/condition/o.html) - [P](https://www.drugs.com/condition/p.html) - [Q](https://www.drugs.com/condition/q.html) - [R](https://www.drugs.com/condition/r.html) - [S](https://www.drugs.com/condition/s.html) - [T](https://www.drugs.com/condition/t.html) - [U](https://www.drugs.com/condition/u.html) - [V](https://www.drugs.com/condition/v.html) - [W](https://www.drugs.com/condition/w.html) - [X](https://www.drugs.com/condition/x.html) - [Y](https://www.drugs.com/condition/y.html) - [Z](https://www.drugs.com/condition/z.html) ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 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