🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 131 (from laksa186)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa131.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/condition/depression.html\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.drugs.com/condition/depression.html\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.drugs.com\/condition\/depression.html","crawl_time":1776359877,"first_indexed_time":1465941705,"http_code":200,"src_unparsed":"com,drugs!www,\/condition\/depression.html s443","src_root_hash":"1816286668162245731","history_drop_reason":null,"meta_title":"List of 90 Depression Medications Compared","meta_descriptions":["Compare risks and benefits of common medications used for Depression. Find the most popular drugs, view ratings and user reviews."],"attrs_boilerpipe_text":"Depression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression.\nWhat Causes Depression?\nExperts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression.\nThe risk of developing depression is higher in women and people:\nAged 45 to 64 years of age or the elderly\nWith chronic or acute health conditions\nWho are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse\nWith severe grief due to the death of a loved one\nTaking prescription drugs that may cause a low mood\nAbusing alcohol or drugs.\nWhat are the Symptoms of Depression?\nDepression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities.\nSymptoms may vary depending on how severe a person’s depression is but may include:\nA prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks\nIrritability\nAnxiety\nAgitation or restlessness\nAvoidance or refusal to participate in activities that were previously enjoyed\nWithdrawal socially, from family, friends, and relationships\nChanges in sleeping or eating habits\nUnexplained physical problems, such as back pain or headaches\nAlcohol, drug, or substance abuse\nEngaging in risky or destructive behaviors\nSelf-harm or attempts at suicide.\nIn children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school.\nIn older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue.\nHow is Depression Diagnosed?\nIf your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist.\nYou can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http:\/\/suicidepreventionlifeline.org\/). All information is confidential and free.\nHow is Depression Treated?\nDepression is treatable with high rates of success. Treatments may include:\nPsychotherapy\nAntidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs).\nResponses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them.\nThere are several things you can do to help with your symptoms as well, such as:\nSetting realistic and daily goals\nDeveloping strategies to work through crises situations\nDeveloping coping and problem-solving skills\nLearning how to develop positive relationships\nReplacing negative thoughts with positive ones.\nDrugs used  to treat Depression\nThe medications listed below are related to or used in the treatment of this condition.\nSelect drug class\nBrands and Generics\nInclude off-label drugs\nRx and OTC\nDrug name\nRating\nReviews\nActivity\n�\nRx\/OTC\nPreg\nnancy\nCSA\nAlcohol\nbupropion\n7.0\n1400 reviews\nfor bupropion to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nbupropion systemic\nBrand names:\nWellbutrin XL,\nWellbutrin SR,\nForfivo XL,\nBudeprion SR,\nAplenzin\nDrug class:\nmiscellaneous antidepressants\n,\nsmoking cessation agents\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nsertraline\n6.9\n1290 reviews\nfor sertraline to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nsertraline systemic\nBrand name:\nZoloft\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nCymbalta\n6.3\n619 reviews\nfor Cymbalta to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nduloxetine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nAugust 4, 2004\nLexapro\n7.2\n632 reviews\nfor Lexapro to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nescitalopram systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nAugust 15, 2002\nZoloft\n6.9\n632 reviews\nfor Zoloft to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nsertraline systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nfluoxetine\n7.0\n745 reviews\nfor fluoxetine to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nfluoxetine systemic\nBrand name:\nProzac\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\ncitalopram\n7.2\n736 reviews\nfor citalopram to treat Depression\nRx\nC\nN\n✕\nGeneric name:\ncitalopram systemic\nBrand name:\nCelexa\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nWellbutrin XL\n7.4\n311 reviews\nfor Wellbutrin XL to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nbupropion systemic\nDrug class:\nmiscellaneous antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nescitalopram\n7.1\n951 reviews\nfor escitalopram to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nescitalopram systemic\nBrand name:\nLexapro\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nProzac\n7.0\n443 reviews\nfor Prozac to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nfluoxetine systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nvenlafaxine\n6.1\n1038 reviews\nfor venlafaxine to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nvenlafaxine systemic\nBrand names:\nEffexor XR,\nEffexor\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nduloxetine\n6.3\n765 reviews\nfor duloxetine to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nduloxetine systemic\nBrand names:\nCymbalta,\nIrenka\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nCelexa\n7.1\n365 reviews\nfor Celexa to treat Depression\nRx\nC\nN\n✕\nGeneric name:\ncitalopram systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nAbilify\n6.4\n347 reviews\nfor Abilify to treat Depression\nRx\nC\nN\n✕\nGeneric name:\naripiprazole systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nNovember 6, 2007\nRexulti\n6.9\n169 reviews\nfor Rexulti to treat Depression\nRx\nN\n✕\nGeneric name:\nbrexpiprazole systemic\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nJuly 10, 2015\narmodafinil\nOff-label\n8.2\n47 reviews\nfor armodafinil to treat Depression\nRx\nC\n4\nGeneric name:\narmodafinil systemic\nDrug class:\nCNS stimulants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nOff-label:\nYes\nbrexpiprazole\n6.9\n184 reviews\nfor brexpiprazole to treat Depression\nRx\nN\n✕\nGeneric name:\nbrexpiprazole systemic\nBrand name:\nRexulti\nDrug class:\natypical antipsychotics\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nEffexor XR\n6.5\n362 reviews\nfor Effexor XR to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nvenlafaxine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\ntrazodone\n6.7\n144 reviews\nfor trazodone to treat Depression\nRx\nC\nN\n✕\nGeneric name:\ntrazodone systemic\nBrand name:\nRaldesy\nDrug class:\nphenylpiperazine antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nmirtazapine\n6.7\n669 reviews\nfor mirtazapine to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nmirtazapine systemic\nBrand names:\nRemeron,\nRemeron SolTab\nDrug class:\ntetracyclic antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nPristiq\n6.9\n800 reviews\nfor Pristiq to treat Depression\nRx\nC\nN\n✕\nGeneric name:\ndesvenlafaxine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\nFDA approval date:\nMarch 3, 2008\nEffexor\n5.5\n342 reviews\nfor Effexor to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nvenlafaxine systemic\nDrug class:\nserotonin-norepinephrine reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\namitriptyline\n8.1\n143 reviews\nfor amitriptyline to treat Depression\nRx\nC\nN\n✕\nGeneric name:\namitriptyline systemic\nDrug class:\ntricyclic antidepressants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nlamotrigine\nOff-label\n7.2\n188 reviews\nfor lamotrigine to treat Depression\nRx\nC\nN\n✕\nGeneric name:\nlamotrigine systemic\nDrug class:\ntriazine anticonvulsants\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nAHFS DI Monograph\n,\nPrescribing Information\nOff-label:\nYes\nPaxil\n6.4\n196 reviews\nfor Paxil to treat Depression\nRx\nD\nN\n✕\nGeneric name:\nparoxetine systemic\nDrug class:\nselective serotonin reuptake inhibitors\nFor consumers:\ndosage\n,\ninteractions\n,\nside effects\nFor professionals:\nPrescribing Information\n1\n2\n3\n4\nNext\nView all\nresults on one page\nFrequently asked questions\nHow to sleep while taking Cymbalta?\nWhat is Exxua?\nCan depression cause headaches?\nSSRIs vs SNRIs - What's the difference between them?\nHow long do venlafaxine withdrawal symptoms last?\nHow long does Xanax last for \/ stay in your system?\nWhat does Prozac feel like when it starts working?\nKlonopin vs Xanax - How are they different?\nHow long does Zoloft (sertraline) take to work?\nView more FAQ\nTopics under Depression\nDepressive Psychosis\n(2 drugs)\nMajor Depressive Disorder\n(60 drugs)\nMajor Depressive Disorder with Acute Suicidal Ideation\n(1 drug)\nPersistent Depressive Disorder\n(10 drugs in 2 topics)\nPostpartum Depression\n(14 drugs)\nSeasonal Affective Disorder\n(2 drugs)\nSexual Dysfunction, SSRI Induced\n(6 drugs)\nAlternative treatments for Depression\nThe following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy\n\t\tmay not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical,\n\t\tcultural or anecdotal evidence linking their use to the treatment of Depression.\n5-HTP Mood and Stress\nGotu kola\nNatrol SAMe\nSt. John's wort\nTryptophan\nValerian\nLegend\nRating\nFor ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective).\nActivity\nActivity is based on recent site visitor activity relative to other medications in the list.\nRx\nAvailable for purchase by prescription only.\nOTC\nAvailable for purchase over-the-counter.\nRx\/OTC\nAvailable for purchase by prescription or over-the-counter.\nAlcohol\nThe medication interacts with alcohol (if marked with \"✕\").\nNew approval\nThe FDA has approved this medication within the past year.\nOff-label\nThe FDA may not approve this medication for the treatment of this condition.\nEUA\nAn Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.\nExpanded access\nExpanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.\nPregnancy Category\nA\nAdequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).\nB\nAnimal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.\nC\nAnimal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.\nD\nThere is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.\n✕\nStudies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.\nN\nFDA has not classified the drug.\nControlled Substances Act (CSA) Schedule\nM\nThe drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.\nU\nCSA Schedule is unknown.\nN\nIs not subject to the Controlled Substances Act.\n1\nHas a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.\n2\nHas a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.\n3\nHas a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.\n4\nHas a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.\n5\nHas a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.\nBrowse treatment options\nA\nB\nC\nD\nE\nF\nG\nH\nI\nJ\nK\nL\nM\nN\nO\nP\nQ\nR\nS\nT\nU\nV\nW\nX\nY\nZ\nFurther information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\nMedical Disclaimer","attrs_markdown":"[Skip to main content](https:\/\/www.drugs.com\/condition\/depression.html#content)\n\n[![Drugs.com - Go to homepage](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo.svg)](https:\/\/www.drugs.com\/)\n\n[Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n\nSite navigation\n\n- [**Upgrade to a Plus Plan** Remove ads and unlock more features.](https:\/\/www.drugs.com\/account\/plan\/?launch=ddc-tier-1)\n- [Register](https:\/\/www.drugs.com\/account\/register\/) [Sign in](https:\/\/www.drugs.com\/account\/login\/)\n- [Drugs A-Z](https:\/\/www.drugs.com\/drug_information.html)\n- [Pill Identifier](https:\/\/www.drugs.com\/pill_identification.html)\n- [Drug Interaction Checker](https:\/\/www.drugs.com\/drug_interactions.html)\n- [Compare Drugs](https:\/\/www.drugs.com\/compare\/)\n- [News](https:\/\/www.drugs.com\/news.html)\n- [Pro Edition](https:\/\/www.drugs.com\/professionals.html)\n- [More Resources](https:\/\/www.drugs.com\/sitemap.html)\n- [Help & Support](https:\/\/www.drugs.com\/support\/)\n\nClose\n\n1. [Home](https:\/\/www.drugs.com\/)\n2. [Treatments](https:\/\/www.drugs.com\/medical_conditions.html)\n3. [Psychiatric Disorders](https:\/\/www.drugs.com\/condition\/history-psychiatric-disorder.html)\n4. Depression\n\nPrint\n# Medications for Depression\nDepression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression.\n\n## What Causes Depression?\nExperts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression.\n\nThe risk of developing depression is higher in women and people:\n\n- Aged 45 to 64 years of age or the elderly\n- With chronic or acute health conditions\n- Who are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse\n- With severe grief due to the death of a loved one\n- Taking prescription drugs that may cause a low mood\n- Abusing alcohol or drugs.\n## What are the Symptoms of Depression?\nDepression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities.\n\nSymptoms may vary depending on how severe a person’s depression is but may include:\n\n- A prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks\n- Irritability\n- Anxiety\n- Agitation or restlessness\n- Avoidance or refusal to participate in activities that were previously enjoyed\n- Withdrawal socially, from family, friends, and relationships\n- Changes in sleeping or eating habits\n- Unexplained physical problems, such as back pain or headaches\n- Alcohol, drug, or substance abuse\n- Engaging in risky or destructive behaviors\n- Self-harm or attempts at suicide.\n\nIn children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school.\n\nIn older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue.\n\n## How is Depression Diagnosed?\nIf your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist.\n\nYou can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http:\/\/suicidepreventionlifeline.org\/). All information is confidential and free.\n\n## How is Depression Treated?\nDepression is treatable with high rates of success. Treatments may include:\n\n- Psychotherapy\n- Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs).\n\nResponses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them.\n\nThere are several things you can do to help with your symptoms as well, such as:\n\n- Setting realistic and daily goals\n- Developing strategies to work through crises situations\n- Developing coping and problem-solving skills\n- Learning how to develop positive relationships\n- Replacing negative thoughts with positive ones.\n## Drugs used to treat Depression\nThe medications listed below are related to or used in the treatment of this condition.\n\n| [Drug name](https:\/\/www.drugs.com\/condition\/depression.html?sort=drug&order=asc) | [Rating](https:\/\/www.drugs.com\/condition\/depression.html?sort=rating&order=desc) | [Reviews](https:\/\/www.drugs.com\/condition\/depression.html?sort=reviews&order=desc) | [Activity](https:\/\/www.drugs.com\/condition\/depression.html?sort=popularity&order=asc)  [�](https:\/\/www.drugs.com\/condition\/depression.html#medication-table-activity) | Rx\/OTC | Pregnancy | CSA | Alcohol |\n|---|---|---|---|---|---|---|---|\n| Expand current row for information about bupropion [bupropion](https:\/\/www.drugs.com\/bupropion.html) |   |   |   |   |   |   |   |\n\n- 1\n- [2](https:\/\/www.drugs.com\/condition\/depression.html?page_number=2)\n- [3](https:\/\/www.drugs.com\/condition\/depression.html?page_number=3)\n- [4](https:\/\/www.drugs.com\/condition\/depression.html?page_number=4)\n- [**Next**](https:\/\/www.drugs.com\/condition\/depression.html?page_number=2)\n- [View all results on one page](https:\/\/www.drugs.com\/condition\/depression.html?page_all=1)\n## Frequently asked questions\n- [How to sleep while taking Cymbalta?](https:\/\/www.drugs.com\/medical-answers\/sleep-taking-cymbalta-3565234\/)\n- [What is Exxua?](https:\/\/www.drugs.com\/medical-answers\/what-exxua-3574145\/)\n- [Can depression cause headaches?](https:\/\/www.drugs.com\/medical-answers\/depression-headaches-3557778\/)\n- [SSRIs vs SNRIs - What's the difference between them?](https:\/\/www.drugs.com\/medical-answers\/difference-between-ssris-snris-3504539\/)\n- [How long do venlafaxine withdrawal symptoms last?](https:\/\/www.drugs.com\/medical-answers\/long-venlafaxine-withdrawal-symptoms-3573466\/)\n- [How long does Xanax last for \/ stay in your system?](https:\/\/www.drugs.com\/medical-answers\/long-xanax-3510962\/)\n- [What does Prozac feel like when it starts working?](https:\/\/www.drugs.com\/medical-answers\/prozac-feel-starts-working-3571159\/)\n- [Klonopin vs Xanax - How are they different?](https:\/\/www.drugs.com\/medical-answers\/klonopin-vs-xanax-3030557\/)\n- [How long does Zoloft (sertraline) take to work?](https:\/\/www.drugs.com\/medical-answers\/long-zoloft-sertraline-work-3565128\/)\n\n[View more FAQ](https:\/\/www.drugs.com\/answers\/support-group\/depression\/questions\/?status=faq)\n\n## Topics under Depression\n- [Depressive Psychosis](https:\/\/www.drugs.com\/condition\/depressive-psychosis.html)  (2 drugs)\n- [Major Depressive Disorder](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html)  (60 drugs)\n- [Major Depressive Disorder with Acute Suicidal Ideation](https:\/\/www.drugs.com\/condition\/depressive-disorder-other.html)  (1 drug)\n- [Persistent Depressive Disorder](https:\/\/www.drugs.com\/condition\/dysthymia.html)  (10 drugs in 2 topics)\n- [Postpartum Depression](https:\/\/www.drugs.com\/condition\/postpartum-depression.html)  (14 drugs)\n- [Seasonal Affective Disorder](https:\/\/www.drugs.com\/condition\/seasonal-affective-disorder.html)  (2 drugs)\n- [Sexual Dysfunction, SSRI Induced](https:\/\/www.drugs.com\/condition\/sexual-dysfunction-ssri-induced.html)  (6 drugs)\n\n## Alternative treatments for Depression\nThe following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression.\n\n- [5-HTP Mood and Stress](https:\/\/www.drugs.com\/mtm\/5-htp-mood-and-stress.html)\n- [Gotu kola](https:\/\/www.drugs.com\/mtm\/gotu-kola.html)\n- [Natrol SAMe](https:\/\/www.drugs.com\/mtm\/natrol-same.html)\n- [St. John's wort](https:\/\/www.drugs.com\/mtm\/st-john-s-wort.html)\n- [Tryptophan](https:\/\/www.drugs.com\/tryptophan.html)\n- [Valerian](https:\/\/www.drugs.com\/mtm\/valerian.html)\n\n## Learn more about Depression\n- [Antidepressants: Options, Advantages, and Precautions](https:\/\/www.drugs.com\/article\/antidepressants.html)\n- [Mixing Alcohol & Antidepressants: Cause for Concern?](https:\/\/www.drugs.com\/article\/antidepressant-medications-alcohol.html)\n#### Care guides\n- [Depression](https:\/\/www.drugs.com\/cg\/depression.html)\n- [Depression Management for Adolescents](https:\/\/www.drugs.com\/cg\/depression-management-for-adolescents.html)\n- [Depression after Spinal Cord Injury](https:\/\/www.drugs.com\/cg\/depression-after-spinal-cord-injury.html)\n#### Symptoms and treatments\n- [Depression](https:\/\/www.drugs.com\/health-guide\/depression.html)\n#### Medicine.com guides (external)\n- [Depression Guide](https:\/\/medicine.com\/guide\/depression)\n\n#### Legend\n|   |   |\n|---|---|\n| Rating | For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |\n| Activity | Activity is based on recent site visitor activity relative to other medications in the list. |\n| Rx | Available for purchase by prescription only. |\n| OTC | Available for purchase over-the-counter. |\n| Rx\/OTC | Available for purchase by prescription or over-the-counter. |\n| Alcohol | The medication interacts with alcohol (if marked with \"✕\"). |\n| New approval | The FDA has approved this medication within the past year. |\n| Off-label | The FDA may not approve this medication for the treatment of this condition. |\n| EUA | An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. |\n| Expanded access | Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. |\n\n| Pregnancy Category |   |\n|---|---|\n| A | Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). |\n| B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. |\n| C | Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| ✕ | Studies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. |\n| N | FDA has not classified the drug. |\n\n| Controlled Substances Act (CSA) Schedule |   |\n|---|---|\n| M | The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. |\n| U | CSA Schedule is unknown. |\n| N | Is not subject to the Controlled Substances Act. |\n| 1 | Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |\n| 2 | Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |\n| 3 | Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |\n| 4 | Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |\n| 5 | Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |\n\n### Browse treatment options\n- [A](https:\/\/www.drugs.com\/condition\/a.html)\n- [B](https:\/\/www.drugs.com\/condition\/b.html)\n- [C](https:\/\/www.drugs.com\/condition\/c.html)\n- [D](https:\/\/www.drugs.com\/condition\/d.html)\n- [E](https:\/\/www.drugs.com\/condition\/e.html)\n- [F](https:\/\/www.drugs.com\/condition\/f.html)\n- [G](https:\/\/www.drugs.com\/condition\/g.html)\n- [H](https:\/\/www.drugs.com\/condition\/h.html)\n- [I](https:\/\/www.drugs.com\/condition\/i.html)\n- [J](https:\/\/www.drugs.com\/condition\/j.html)\n- [K](https:\/\/www.drugs.com\/condition\/k.html)\n- [L](https:\/\/www.drugs.com\/condition\/l.html)\n- [M](https:\/\/www.drugs.com\/condition\/m.html)\n- [N](https:\/\/www.drugs.com\/condition\/n.html)\n- [O](https:\/\/www.drugs.com\/condition\/o.html)\n- [P](https:\/\/www.drugs.com\/condition\/p.html)\n- [Q](https:\/\/www.drugs.com\/condition\/q.html)\n- [R](https:\/\/www.drugs.com\/condition\/r.html)\n- [S](https:\/\/www.drugs.com\/condition\/s.html)\n- [T](https:\/\/www.drugs.com\/condition\/t.html)\n- [U](https:\/\/www.drugs.com\/condition\/u.html)\n- [V](https:\/\/www.drugs.com\/condition\/v.html)\n- [W](https:\/\/www.drugs.com\/condition\/w.html)\n- [X](https:\/\/www.drugs.com\/condition\/x.html)\n- [Y](https:\/\/www.drugs.com\/condition\/y.html)\n- [Z](https:\/\/www.drugs.com\/condition\/z.html)\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)\n\nLatest FDA Approvals for Depression\n\n- [Spravato](https:\/\/www.drugs.com\/newdrugs\/spravato-esketamine-approved-u-s-first-only-monotherapy-adults-resistant-depression-6440.html)\n- [Abilify MyCite](https:\/\/www.drugs.com\/newdrugs\/fda-approves-abilify-mycite-aripiprazole-pill-sensor-digitally-track-if-patients-have-ingested-their-4632.html)\n- [Trintellix](https:\/\/www.drugs.com\/newdrugs\/fda-approves-brintellix-major-depressive-disorder-3918.html)\n\n**Drugs.com Mobile App**\n\nAccess drug & treatment information, identify pills, check interactions and set up personal medication records.\n\n[Download the Medication Guide app on iTunes ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/apple-store.png)](https:\/\/apps.apple.com\/us\/app\/drugs-com-medication-guide\/id599471042?platform=iphone)   [Download the Medication Guide app on the Google Play store ![](https:\/\/www.drugs.com\/img\/v-20250930\/apps\/google-play.png)](https:\/\/play.google.com\/store\/apps\/details?id=com.drugscom.app)\n\n![Drugs.com mobile app](https:\/\/www.drugs.com\/img\/v-20250709\/apps\/promo-uberapp.png)\n\n[Drugs.com ![](https:\/\/www.drugs.com\/img\/logo\/drugscom-logo-mark.svg)](https:\/\/www.drugs.com\/)\n\n**About**\n\n- [About Drugs.com](https:\/\/www.drugs.com\/support\/about.html)\n- [Advertising policy](https:\/\/www.drugs.com\/support\/advertising.html)\n- [Attribution & citations](https:\/\/www.drugs.com\/support\/citations.html)\n- [Drugs.com Podcast](https:\/\/podcasts.drugs.com\/)\n\n**Terms & privacy**\n\n- [Terms of use](https:\/\/www.drugs.com\/support\/terms.html)\n- [Editorial policy](https:\/\/www.drugs.com\/support\/editorial-policy.html)\n- [Privacy policy](https:\/\/www.drugs.com\/support\/privacy.html)\n- [Privacy settings](https:\/\/www.drugs.com\/condition\/depression.html)\n\n**Support**\n\n- [Help center](https:\/\/www.drugs.com\/support\/)\n- [Sitemap](https:\/\/www.drugs.com\/sitemap.html)\n- [Contact us](https:\/\/www.drugs.com\/support\/contact.html)\n- [Accessibility](https:\/\/www.drugs.com\/support\/accessibility.html)\n\n- [Subscribe to Drugs.com newsletters](https:\/\/www.drugs.com\/newsletters\/)\n- [Follow Drugs.com on Facebook](https:\/\/www.facebook.com\/Drugscom)\n- [Follow Drugs.com on X (Twitter)](https:\/\/x.com\/drugscom)\n- [Follow Drugs.com on Instagram](https:\/\/www.instagram.com\/drugs.com_official\/)\n- [Follow Drugs.com on YouTube](https:\/\/www.youtube.com\/user\/drugscom)\n- [Follow Drugs.com on Pinterest](https:\/\/www.pinterest.com\/drugscom\/)\n\n[Subscribe to our newsletter](https:\/\/www.drugs.com\/newsletters\/) for the latest medication news, new drug approvals and FDA alerts.\n\n**Drugs.com** provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated Mar 31, 2026), Cerner Multum™ (updated Apr 12, 2026), ASHP (updated Mar 10, 2026) and others.\n\n[![Certified by TRUSTe](https:\/\/privacy-policy.truste.com\/privacy-seal\/seal?rid=d18cba4a-afc4-4863-af81-8262bb120271)](https:\/\/privacy.truste.com\/privacy-seal\/validation?rid=d18cba4a-afc4-4863-af81-8262bb120271)  ![Verified by TAG](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/tag-verified.png)  [![This website is certified by AACI. Click to verify.](https:\/\/www.drugs.com\/img\/v-20251028\/logo\/vendor\/trust-mark-logo.png)](https:\/\/aacihealthcare.com\/certificates\/c173-2022-trust-us\/)   [![AdChoices - Ad privacy information](https:\/\/www.drugs.com\/img\/v-20240725\/logo\/vendor\/adchoices-logomark.png)](https:\/\/www.drugs.com\/support\/privacy\/advertising.html)\n\nCopyright © 2000-2026 Drugs.com. All rights reserved.","attrs_readable_markdown":"Depression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression.\n\n## What Causes Depression?\nExperts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression.\n\nThe risk of developing depression is higher in women and people:\n\n- Aged 45 to 64 years of age or the elderly\n- With chronic or acute health conditions\n- Who are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse\n- With severe grief due to the death of a loved one\n- Taking prescription drugs that may cause a low mood\n- Abusing alcohol or drugs.\n## What are the Symptoms of Depression?\nDepression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities.\n\nSymptoms may vary depending on how severe a person’s depression is but may include:\n\n- A prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks\n- Irritability\n- Anxiety\n- Agitation or restlessness\n- Avoidance or refusal to participate in activities that were previously enjoyed\n- Withdrawal socially, from family, friends, and relationships\n- Changes in sleeping or eating habits\n- Unexplained physical problems, such as back pain or headaches\n- Alcohol, drug, or substance abuse\n- Engaging in risky or destructive behaviors\n- Self-harm or attempts at suicide.\n\nIn children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school.\n\nIn older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue.\n\n## How is Depression Diagnosed?\nIf your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist.\n\nYou can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http:\/\/suicidepreventionlifeline.org\/). All information is confidential and free.\n\n## How is Depression Treated?\nDepression is treatable with high rates of success. Treatments may include:\n\n- Psychotherapy\n- Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs).\n\nResponses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them.\n\nThere are several things you can do to help with your symptoms as well, such as:\n\n- Setting realistic and daily goals\n- Developing strategies to work through crises situations\n- Developing coping and problem-solving skills\n- Learning how to develop positive relationships\n- Replacing negative thoughts with positive ones.\n## Drugs used to treat Depression\nThe medications listed below are related to or used in the treatment of this condition.\n\n| [Drug name](https:\/\/www.drugs.com\/condition\/depression.html?sort=drug&order=asc) | [Rating](https:\/\/www.drugs.com\/condition\/depression.html?sort=rating&order=desc) | [Reviews](https:\/\/www.drugs.com\/condition\/depression.html?sort=reviews&order=desc) | [Activity](https:\/\/www.drugs.com\/condition\/depression.html?sort=popularity&order=asc)  [�](https:\/\/www.drugs.com\/condition\/depression.html#medication-table-activity) | Rx\/OTC | Pregnancy | CSA | Alcohol |\n|---|---|---|---|---|---|---|---|\n| [bupropion](https:\/\/www.drugs.com\/bupropion.html) |   |   |   |   |   |   |   |\n\n- 1\n- [2](https:\/\/www.drugs.com\/condition\/depression.html?page_number=2)\n- [3](https:\/\/www.drugs.com\/condition\/depression.html?page_number=3)\n- [4](https:\/\/www.drugs.com\/condition\/depression.html?page_number=4)\n- [**Next**](https:\/\/www.drugs.com\/condition\/depression.html?page_number=2)\n- [View all results on one page](https:\/\/www.drugs.com\/condition\/depression.html?page_all=1)\n## Frequently asked questions\n- [How to sleep while taking Cymbalta?](https:\/\/www.drugs.com\/medical-answers\/sleep-taking-cymbalta-3565234\/)\n- [What is Exxua?](https:\/\/www.drugs.com\/medical-answers\/what-exxua-3574145\/)\n- [Can depression cause headaches?](https:\/\/www.drugs.com\/medical-answers\/depression-headaches-3557778\/)\n- [SSRIs vs SNRIs - What's the difference between them?](https:\/\/www.drugs.com\/medical-answers\/difference-between-ssris-snris-3504539\/)\n- [How long do venlafaxine withdrawal symptoms last?](https:\/\/www.drugs.com\/medical-answers\/long-venlafaxine-withdrawal-symptoms-3573466\/)\n- [How long does Xanax last for \/ stay in your system?](https:\/\/www.drugs.com\/medical-answers\/long-xanax-3510962\/)\n- [What does Prozac feel like when it starts working?](https:\/\/www.drugs.com\/medical-answers\/prozac-feel-starts-working-3571159\/)\n- [Klonopin vs Xanax - How are they different?](https:\/\/www.drugs.com\/medical-answers\/klonopin-vs-xanax-3030557\/)\n- [How long does Zoloft (sertraline) take to work?](https:\/\/www.drugs.com\/medical-answers\/long-zoloft-sertraline-work-3565128\/)\n\n[View more FAQ](https:\/\/www.drugs.com\/answers\/support-group\/depression\/questions\/?status=faq)\n\n## Topics under Depression\n- [Depressive Psychosis](https:\/\/www.drugs.com\/condition\/depressive-psychosis.html)  (2 drugs)\n- [Major Depressive Disorder](https:\/\/www.drugs.com\/condition\/major-depressive-disorder.html)  (60 drugs)\n- [Major Depressive Disorder with Acute Suicidal Ideation](https:\/\/www.drugs.com\/condition\/depressive-disorder-other.html)  (1 drug)\n- [Persistent Depressive Disorder](https:\/\/www.drugs.com\/condition\/dysthymia.html)  (10 drugs in 2 topics)\n- [Postpartum Depression](https:\/\/www.drugs.com\/condition\/postpartum-depression.html)  (14 drugs)\n- [Seasonal Affective Disorder](https:\/\/www.drugs.com\/condition\/seasonal-affective-disorder.html)  (2 drugs)\n- [Sexual Dysfunction, SSRI Induced](https:\/\/www.drugs.com\/condition\/sexual-dysfunction-ssri-induced.html)  (6 drugs)\n\n## Alternative treatments for Depression\nThe following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression.\n\n- [5-HTP Mood and Stress](https:\/\/www.drugs.com\/mtm\/5-htp-mood-and-stress.html)\n- [Gotu kola](https:\/\/www.drugs.com\/mtm\/gotu-kola.html)\n- [Natrol SAMe](https:\/\/www.drugs.com\/mtm\/natrol-same.html)\n- [St. John's wort](https:\/\/www.drugs.com\/mtm\/st-john-s-wort.html)\n- [Tryptophan](https:\/\/www.drugs.com\/tryptophan.html)\n- [Valerian](https:\/\/www.drugs.com\/mtm\/valerian.html)\n\n#### Legend\n|   |   |\n|---|---|\n| Rating | For ratings, users were asked how effective they found the medicine while considering positive\/adverse effects and ease of use (1 = not effective, 10 = most effective). |\n| Activity | Activity is based on recent site visitor activity relative to other medications in the list. |\n| Rx | Available for purchase by prescription only. |\n| OTC | Available for purchase over-the-counter. |\n| Rx\/OTC | Available for purchase by prescription or over-the-counter. |\n| Alcohol | The medication interacts with alcohol (if marked with \"✕\"). |\n| New approval | The FDA has approved this medication within the past year. |\n| Off-label | The FDA may not approve this medication for the treatment of this condition. |\n| EUA | An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. |\n| Expanded access | Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. |\n\n| Pregnancy Category |   |\n|---|---|\n| A | Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). |\n| B | Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. |\n| C | Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |\n| ✕ | Studies in animals or humans have demonstrated fetal abnormalities and\/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. |\n| N | FDA has not classified the drug. |\n\n| Controlled Substances Act (CSA) Schedule |   |\n|---|---|\n| M | The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. |\n| U | CSA Schedule is unknown. |\n| N | Is not subject to the Controlled Substances Act. |\n| 1 | Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |\n| 2 | Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. |\n| 3 | Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. |\n| 4 | Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. |\n| 5 | Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. |\n\n### Browse treatment options\n- [A](https:\/\/www.drugs.com\/condition\/a.html)\n- [B](https:\/\/www.drugs.com\/condition\/b.html)\n- [C](https:\/\/www.drugs.com\/condition\/c.html)\n- [D](https:\/\/www.drugs.com\/condition\/d.html)\n- [E](https:\/\/www.drugs.com\/condition\/e.html)\n- [F](https:\/\/www.drugs.com\/condition\/f.html)\n- [G](https:\/\/www.drugs.com\/condition\/g.html)\n- [H](https:\/\/www.drugs.com\/condition\/h.html)\n- [I](https:\/\/www.drugs.com\/condition\/i.html)\n- [J](https:\/\/www.drugs.com\/condition\/j.html)\n- [K](https:\/\/www.drugs.com\/condition\/k.html)\n- [L](https:\/\/www.drugs.com\/condition\/l.html)\n- [M](https:\/\/www.drugs.com\/condition\/m.html)\n- [N](https:\/\/www.drugs.com\/condition\/n.html)\n- [O](https:\/\/www.drugs.com\/condition\/o.html)\n- [P](https:\/\/www.drugs.com\/condition\/p.html)\n- [Q](https:\/\/www.drugs.com\/condition\/q.html)\n- [R](https:\/\/www.drugs.com\/condition\/r.html)\n- [S](https:\/\/www.drugs.com\/condition\/s.html)\n- [T](https:\/\/www.drugs.com\/condition\/t.html)\n- [U](https:\/\/www.drugs.com\/condition\/u.html)\n- [V](https:\/\/www.drugs.com\/condition\/v.html)\n- [W](https:\/\/www.drugs.com\/condition\/w.html)\n- [X](https:\/\/www.drugs.com\/condition\/x.html)\n- [Y](https:\/\/www.drugs.com\/condition\/y.html)\n- [Z](https:\/\/www.drugs.com\/condition\/z.html)\n## Further information\nAlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.\n\n[Medical Disclaimer](https:\/\/www.drugs.com\/support\/disclaimer.html)","meta_canonical":null}

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Meta Title	List of 90 Depression Medications Compared
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Boilerpipe Text	Depression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression. What Causes Depression? Experts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression. The risk of developing depression is higher in women and people: Aged 45 to 64 years of age or the elderly With chronic or acute health conditions Who are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse With severe grief due to the death of a loved one Taking prescription drugs that may cause a low mood Abusing alcohol or drugs. What are the Symptoms of Depression? Depression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities. Symptoms may vary depending on how severe a person’s depression is but may include: A prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks Irritability Anxiety Agitation or restlessness Avoidance or refusal to participate in activities that were previously enjoyed Withdrawal socially, from family, friends, and relationships Changes in sleeping or eating habits Unexplained physical problems, such as back pain or headaches Alcohol, drug, or substance abuse Engaging in risky or destructive behaviors Self-harm or attempts at suicide. In children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school. In older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue. How is Depression Diagnosed? If your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist. You can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http://suicidepreventionlifeline.org/). All information is confidential and free. How is Depression Treated? Depression is treatable with high rates of success. Treatments may include: Psychotherapy Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs). Responses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them. There are several things you can do to help with your symptoms as well, such as: Setting realistic and daily goals Developing strategies to work through crises situations Developing coping and problem-solving skills Learning how to develop positive relationships Replacing negative thoughts with positive ones. Drugs used to treat Depression The medications listed below are related to or used in the treatment of this condition. Select drug class Brands and Generics Include off-label drugs Rx and OTC Drug name Rating Reviews Activity � Rx/OTC Preg nancy CSA Alcohol bupropion 7.0 1400 reviews for bupropion to treat Depression Rx C N ✕ Generic name: bupropion systemic Brand names: Wellbutrin XL, Wellbutrin SR, Forfivo XL, Budeprion SR, Aplenzin Drug class: miscellaneous antidepressants , smoking cessation agents For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information sertraline 6.9 1290 reviews for sertraline to treat Depression Rx C N ✕ Generic name: sertraline systemic Brand name: Zoloft Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Cymbalta 6.3 619 reviews for Cymbalta to treat Depression Rx C N ✕ Generic name: duloxetine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: August 4, 2004 Lexapro 7.2 632 reviews for Lexapro to treat Depression Rx C N ✕ Generic name: escitalopram systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: August 15, 2002 Zoloft 6.9 632 reviews for Zoloft to treat Depression Rx C N ✕ Generic name: sertraline systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information fluoxetine 7.0 745 reviews for fluoxetine to treat Depression Rx C N ✕ Generic name: fluoxetine systemic Brand name: Prozac Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information citalopram 7.2 736 reviews for citalopram to treat Depression Rx C N ✕ Generic name: citalopram systemic Brand name: Celexa Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Wellbutrin XL 7.4 311 reviews for Wellbutrin XL to treat Depression Rx C N ✕ Generic name: bupropion systemic Drug class: miscellaneous antidepressants For consumers: dosage , interactions , side effects For professionals: Prescribing Information escitalopram 7.1 951 reviews for escitalopram to treat Depression Rx C N ✕ Generic name: escitalopram systemic Brand name: Lexapro Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Prozac 7.0 443 reviews for Prozac to treat Depression Rx C N ✕ Generic name: fluoxetine systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information venlafaxine 6.1 1038 reviews for venlafaxine to treat Depression Rx C N ✕ Generic name: venlafaxine systemic Brand names: Effexor XR, Effexor Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information duloxetine 6.3 765 reviews for duloxetine to treat Depression Rx C N ✕ Generic name: duloxetine systemic Brand names: Cymbalta, Irenka Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Celexa 7.1 365 reviews for Celexa to treat Depression Rx C N ✕ Generic name: citalopram systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information Abilify 6.4 347 reviews for Abilify to treat Depression Rx C N ✕ Generic name: aripiprazole systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: November 6, 2007 Rexulti 6.9 169 reviews for Rexulti to treat Depression Rx N ✕ Generic name: brexpiprazole systemic Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: July 10, 2015 armodafinil Off-label 8.2 47 reviews for armodafinil to treat Depression Rx C 4 Generic name: armodafinil systemic Drug class: CNS stimulants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Off-label: Yes brexpiprazole 6.9 184 reviews for brexpiprazole to treat Depression Rx N ✕ Generic name: brexpiprazole systemic Brand name: Rexulti Drug class: atypical antipsychotics For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Effexor XR 6.5 362 reviews for Effexor XR to treat Depression Rx C N ✕ Generic name: venlafaxine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information trazodone 6.7 144 reviews for trazodone to treat Depression Rx C N ✕ Generic name: trazodone systemic Brand name: Raldesy Drug class: phenylpiperazine antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information mirtazapine 6.7 669 reviews for mirtazapine to treat Depression Rx C N ✕ Generic name: mirtazapine systemic Brand names: Remeron, Remeron SolTab Drug class: tetracyclic antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Pristiq 6.9 800 reviews for Pristiq to treat Depression Rx C N ✕ Generic name: desvenlafaxine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information FDA approval date: March 3, 2008 Effexor 5.5 342 reviews for Effexor to treat Depression Rx C N ✕ Generic name: venlafaxine systemic Drug class: serotonin-norepinephrine reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information amitriptyline 8.1 143 reviews for amitriptyline to treat Depression Rx C N ✕ Generic name: amitriptyline systemic Drug class: tricyclic antidepressants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information lamotrigine Off-label 7.2 188 reviews for lamotrigine to treat Depression Rx C N ✕ Generic name: lamotrigine systemic Drug class: triazine anticonvulsants For consumers: dosage , interactions , side effects For professionals: AHFS DI Monograph , Prescribing Information Off-label: Yes Paxil 6.4 196 reviews for Paxil to treat Depression Rx D N ✕ Generic name: paroxetine systemic Drug class: selective serotonin reuptake inhibitors For consumers: dosage , interactions , side effects For professionals: Prescribing Information 1 2 3 4 Next View all results on one page Frequently asked questions How to sleep while taking Cymbalta? What is Exxua? Can depression cause headaches? SSRIs vs SNRIs - What's the difference between them? How long do venlafaxine withdrawal symptoms last? How long does Xanax last for / stay in your system? What does Prozac feel like when it starts working? Klonopin vs Xanax - How are they different? How long does Zoloft (sertraline) take to work? View more FAQ Topics under Depression Depressive Psychosis (2 drugs) Major Depressive Disorder (60 drugs) Major Depressive Disorder with Acute Suicidal Ideation (1 drug) Persistent Depressive Disorder (10 drugs in 2 topics) Postpartum Depression (14 drugs) Seasonal Affective Disorder (2 drugs) Sexual Dysfunction, SSRI Induced (6 drugs) Alternative treatments for Depression The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression. 5-HTP Mood and Stress Gotu kola Natrol SAMe St. John's wort Tryptophan Valerian Legend Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Activity Activity is based on recent site visitor activity relative to other medications in the list. Rx Available for purchase by prescription only. OTC Available for purchase over-the-counter. Rx/OTC Available for purchase by prescription or over-the-counter. Alcohol The medication interacts with alcohol (if marked with "✕"). New approval The FDA has approved this medication within the past year. Off-label The FDA may not approve this medication for the treatment of this condition. EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. Expanded access Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. Pregnancy Category A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. ✕ Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. N FDA has not classified the drug. Controlled Substances Act (CSA) Schedule M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. U CSA Schedule is unknown. N Is not subject to the Controlled Substances Act. 1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. 2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. 3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. 4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. 5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. Browse treatment options A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Medical Disclaimer
Markdown	[Skip to main content](https://www.drugs.com/condition/depression.html#content) [![Drugs.com - Go to homepage](https://www.drugs.com/img/logo/drugscom-logo.svg)](https://www.drugs.com/) [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) Site navigation - [Upgrade to a Plus Plan Remove ads and unlock more features.](https://www.drugs.com/account/plan/?launch=ddc-tier-1) - [Register](https://www.drugs.com/account/register/) [Sign in](https://www.drugs.com/account/login/) - [Drugs A-Z](https://www.drugs.com/drug_information.html) - [Pill Identifier](https://www.drugs.com/pill_identification.html) - [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html) - [Compare Drugs](https://www.drugs.com/compare/) - [News](https://www.drugs.com/news.html) - [Pro Edition](https://www.drugs.com/professionals.html) - [More Resources](https://www.drugs.com/sitemap.html) - [Help & Support](https://www.drugs.com/support/) Close 1. [Home](https://www.drugs.com/) 2. [Treatments](https://www.drugs.com/medical_conditions.html) 3. [Psychiatric Disorders](https://www.drugs.com/condition/history-psychiatric-disorder.html) 4. Depression Print # Medications for Depression Depression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression. ## What Causes Depression? Experts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression. The risk of developing depression is higher in women and people: - Aged 45 to 64 years of age or the elderly - With chronic or acute health conditions - Who are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse - With severe grief due to the death of a loved one - Taking prescription drugs that may cause a low mood - Abusing alcohol or drugs. ## What are the Symptoms of Depression? Depression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities. Symptoms may vary depending on how severe a person’s depression is but may include: - A prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks - Irritability - Anxiety - Agitation or restlessness - Avoidance or refusal to participate in activities that were previously enjoyed - Withdrawal socially, from family, friends, and relationships - Changes in sleeping or eating habits - Unexplained physical problems, such as back pain or headaches - Alcohol, drug, or substance abuse - Engaging in risky or destructive behaviors - Self-harm or attempts at suicide. In children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school. In older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue. ## How is Depression Diagnosed? If your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist. You can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http://suicidepreventionlifeline.org/). All information is confidential and free. ## How is Depression Treated? Depression is treatable with high rates of success. Treatments may include: - Psychotherapy - Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs). Responses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them. There are several things you can do to help with your symptoms as well, such as: - Setting realistic and daily goals - Developing strategies to work through crises situations - Developing coping and problem-solving skills - Learning how to develop positive relationships - Replacing negative thoughts with positive ones. ## Drugs used to treat Depression The medications listed below are related to or used in the treatment of this condition. \| [Drug name](https://www.drugs.com/condition/depression.html?sort=drug&order=asc) \| [Rating](https://www.drugs.com/condition/depression.html?sort=rating&order=desc) \| [Reviews](https://www.drugs.com/condition/depression.html?sort=reviews&order=desc) \| [Activity](https://www.drugs.com/condition/depression.html?sort=popularity&order=asc) [�](https://www.drugs.com/condition/depression.html#medication-table-activity) \| Rx/OTC \| Pregnancy \| CSA \| Alcohol \| \|---\|---\|---\|---\|---\|---\|---\|---\| \| Expand current row for information about bupropion [bupropion](https://www.drugs.com/bupropion.html) \| \| \| \| \| \| \| \| - 1 - [2](https://www.drugs.com/condition/depression.html?page_number=2) - [3](https://www.drugs.com/condition/depression.html?page_number=3) - [4](https://www.drugs.com/condition/depression.html?page_number=4) - [Next](https://www.drugs.com/condition/depression.html?page_number=2) - [View all results on one page](https://www.drugs.com/condition/depression.html?page_all=1) ## Frequently asked questions - [How to sleep while taking Cymbalta?](https://www.drugs.com/medical-answers/sleep-taking-cymbalta-3565234/) - [What is Exxua?](https://www.drugs.com/medical-answers/what-exxua-3574145/) - [Can depression cause headaches?](https://www.drugs.com/medical-answers/depression-headaches-3557778/) - [SSRIs vs SNRIs - What's the difference between them?](https://www.drugs.com/medical-answers/difference-between-ssris-snris-3504539/) - [How long do venlafaxine withdrawal symptoms last?](https://www.drugs.com/medical-answers/long-venlafaxine-withdrawal-symptoms-3573466/) - [How long does Xanax last for / stay in your system?](https://www.drugs.com/medical-answers/long-xanax-3510962/) - [What does Prozac feel like when it starts working?](https://www.drugs.com/medical-answers/prozac-feel-starts-working-3571159/) - [Klonopin vs Xanax - How are they different?](https://www.drugs.com/medical-answers/klonopin-vs-xanax-3030557/) - [How long does Zoloft (sertraline) take to work?](https://www.drugs.com/medical-answers/long-zoloft-sertraline-work-3565128/) [View more FAQ](https://www.drugs.com/answers/support-group/depression/questions/?status=faq) ## Topics under Depression - [Depressive Psychosis](https://www.drugs.com/condition/depressive-psychosis.html) (2 drugs) - [Major Depressive Disorder](https://www.drugs.com/condition/major-depressive-disorder.html) (60 drugs) - [Major Depressive Disorder with Acute Suicidal Ideation](https://www.drugs.com/condition/depressive-disorder-other.html) (1 drug) - [Persistent Depressive Disorder](https://www.drugs.com/condition/dysthymia.html) (10 drugs in 2 topics) - [Postpartum Depression](https://www.drugs.com/condition/postpartum-depression.html) (14 drugs) - [Seasonal Affective Disorder](https://www.drugs.com/condition/seasonal-affective-disorder.html) (2 drugs) - [Sexual Dysfunction, SSRI Induced](https://www.drugs.com/condition/sexual-dysfunction-ssri-induced.html) (6 drugs) ## Alternative treatments for Depression The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression. - [5-HTP Mood and Stress](https://www.drugs.com/mtm/5-htp-mood-and-stress.html) - [Gotu kola](https://www.drugs.com/mtm/gotu-kola.html) - [Natrol SAMe](https://www.drugs.com/mtm/natrol-same.html) - [St. John's wort](https://www.drugs.com/mtm/st-john-s-wort.html) - [Tryptophan](https://www.drugs.com/tryptophan.html) - [Valerian](https://www.drugs.com/mtm/valerian.html) ## Learn more about Depression - [Antidepressants: Options, Advantages, and Precautions](https://www.drugs.com/article/antidepressants.html) - [Mixing Alcohol & Antidepressants: Cause for Concern?](https://www.drugs.com/article/antidepressant-medications-alcohol.html) #### Care guides - [Depression](https://www.drugs.com/cg/depression.html) - [Depression Management for Adolescents](https://www.drugs.com/cg/depression-management-for-adolescents.html) - [Depression after Spinal Cord Injury](https://www.drugs.com/cg/depression-after-spinal-cord-injury.html) #### Symptoms and treatments - [Depression](https://www.drugs.com/health-guide/depression.html) #### Medicine.com guides (external) - [Depression Guide](https://medicine.com/guide/depression) #### Legend \| \| \| \|---\|---\| \| Rating \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| Activity \| Activity is based on recent site visitor activity relative to other medications in the list. \| \| Rx \| Available for purchase by prescription only. \| \| OTC \| Available for purchase over-the-counter. \| \| Rx/OTC \| Available for purchase by prescription or over-the-counter. \| \| Alcohol \| The medication interacts with alcohol (if marked with "✕"). \| \| New approval \| The FDA has approved this medication within the past year. \| \| Off-label \| The FDA may not approve this medication for the treatment of this condition. \| \| EUA \| An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. \| \| Expanded access \| Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. \| \| Pregnancy Category \| \| \|---\|---\| \| A \| Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). \| \| B \| Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. \| \| C \| Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| D \| There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| ✕ \| Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. \| \| N \| FDA has not classified the drug. \| \| Controlled Substances Act (CSA) Schedule \| \| \|---\|---\| \| M \| The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. \| \| U \| CSA Schedule is unknown. \| \| N \| Is not subject to the Controlled Substances Act. \| \| 1 \| Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. \| \| 2 \| Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. \| \| 3 \| Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. \| \| 4 \| Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. \| \| 5 \| Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. \| ### Browse treatment options - [A](https://www.drugs.com/condition/a.html) - [B](https://www.drugs.com/condition/b.html) - [C](https://www.drugs.com/condition/c.html) - [D](https://www.drugs.com/condition/d.html) - [E](https://www.drugs.com/condition/e.html) - [F](https://www.drugs.com/condition/f.html) - [G](https://www.drugs.com/condition/g.html) - [H](https://www.drugs.com/condition/h.html) - [I](https://www.drugs.com/condition/i.html) - [J](https://www.drugs.com/condition/j.html) - [K](https://www.drugs.com/condition/k.html) - [L](https://www.drugs.com/condition/l.html) - [M](https://www.drugs.com/condition/m.html) - [N](https://www.drugs.com/condition/n.html) - [O](https://www.drugs.com/condition/o.html) - [P](https://www.drugs.com/condition/p.html) - [Q](https://www.drugs.com/condition/q.html) - [R](https://www.drugs.com/condition/r.html) - [S](https://www.drugs.com/condition/s.html) - [T](https://www.drugs.com/condition/t.html) - [U](https://www.drugs.com/condition/u.html) - [V](https://www.drugs.com/condition/v.html) - [W](https://www.drugs.com/condition/w.html) - [X](https://www.drugs.com/condition/x.html) - [Y](https://www.drugs.com/condition/y.html) - [Z](https://www.drugs.com/condition/z.html) ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. [Medical Disclaimer](https://www.drugs.com/support/disclaimer.html) Latest FDA Approvals for Depression - [Spravato](https://www.drugs.com/newdrugs/spravato-esketamine-approved-u-s-first-only-monotherapy-adults-resistant-depression-6440.html) - [Abilify MyCite](https://www.drugs.com/newdrugs/fda-approves-abilify-mycite-aripiprazole-pill-sensor-digitally-track-if-patients-have-ingested-their-4632.html) - [Trintellix](https://www.drugs.com/newdrugs/fda-approves-brintellix-major-depressive-disorder-3918.html) Drugs.com Mobile App Access drug & treatment information, identify pills, check interactions and set up personal medication records. 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Readable Markdown	Depression is a mood condition characterized by persistent and overwhelming feelings of sadness that can affect your day-to-day activities and how you think, feel, and behave. Sometimes it can affect your outlook on life and make you feel that life isn’t worth living. Depression may also be called major depressive disorder or clinical depression. ## What Causes Depression? Experts aren’t exactly sure what causes depression but believe it is due to a combination of different factors, such as genetic vulnerability, faulty mood regulation by the brain, stress, chemicals in the brain, medications, or medical problems, that all interact together to bring on depression. The risk of developing depression is higher in women and people: - Aged 45 to 64 years of age or the elderly - With chronic or acute health conditions - Who are undergoing a major life event, such as a job loss, divorce, workplace stress, or physical or mental abuse - With severe grief due to the death of a loved one - Taking prescription drugs that may cause a low mood - Abusing alcohol or drugs. ## What are the Symptoms of Depression? Depression is not just feeling blue occasionally. It affects daily feelings, thoughts, and actions over a longer period. (MDD), can result in difficulties with family life, work, and social activities. Symptoms may vary depending on how severe a person’s depression is but may include: - A prolonged and persistent low mood, tearfulness, or a sense of hopelessness that has lasted for at least 2 weeks - Irritability - Anxiety - Agitation or restlessness - Avoidance or refusal to participate in activities that were previously enjoyed - Withdrawal socially, from family, friends, and relationships - Changes in sleeping or eating habits - Unexplained physical problems, such as back pain or headaches - Alcohol, drug, or substance abuse - Engaging in risky or destructive behaviors - Self-harm or attempts at suicide. In children and teens, symptoms may include clinginess, worry, aches and pain, and refusal to go to school. In older adults, symptoms may be less obvious and include memory difficulties or personality changes, physical aches and pains, and fatigue. ## How is Depression Diagnosed? If your mood has been low for a while and you are having difficulty coping with day to day activities, talk to your doctor or a trusted professional. Your doctor will ask you questions about your symptoms and your medical history and may ask you to complete a questionnaire that may help to diagnose depression or refer you to a psychiatrist. You can also call the National Suicide Prevention Hotline at 1-800-273-8255, 24 hours a day, 7 days a week, or have an online chat (http://suicidepreventionlifeline.org/). All information is confidential and free. ## How is Depression Treated? Depression is treatable with high rates of success. Treatments may include: - Psychotherapy - Antidepressants, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin Norepinephrine Reuptake Inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs). Responses to antidepressants vary, and most antidepressants take 4 to 6 weeks for full effect. About 50% of patients respond to the first treatment, whereas others may have to try a few different types of antidepressants before they find the best one for them. There are several things you can do to help with your symptoms as well, such as: - Setting realistic and daily goals - Developing strategies to work through crises situations - Developing coping and problem-solving skills - Learning how to develop positive relationships - Replacing negative thoughts with positive ones. ## Drugs used to treat Depression The medications listed below are related to or used in the treatment of this condition. \| [Drug name](https://www.drugs.com/condition/depression.html?sort=drug&order=asc) \| [Rating](https://www.drugs.com/condition/depression.html?sort=rating&order=desc) \| [Reviews](https://www.drugs.com/condition/depression.html?sort=reviews&order=desc) \| [Activity](https://www.drugs.com/condition/depression.html?sort=popularity&order=asc) [�](https://www.drugs.com/condition/depression.html#medication-table-activity) \| Rx/OTC \| Pregnancy \| CSA \| Alcohol \| \|---\|---\|---\|---\|---\|---\|---\|---\| \| [bupropion](https://www.drugs.com/bupropion.html) \| \| \| \| \| \| \| \| - 1 - [2](https://www.drugs.com/condition/depression.html?page_number=2) - [3](https://www.drugs.com/condition/depression.html?page_number=3) - [4](https://www.drugs.com/condition/depression.html?page_number=4) - [Next](https://www.drugs.com/condition/depression.html?page_number=2) - [View all results on one page](https://www.drugs.com/condition/depression.html?page_all=1) ## Frequently asked questions - [How to sleep while taking Cymbalta?](https://www.drugs.com/medical-answers/sleep-taking-cymbalta-3565234/) - [What is Exxua?](https://www.drugs.com/medical-answers/what-exxua-3574145/) - [Can depression cause headaches?](https://www.drugs.com/medical-answers/depression-headaches-3557778/) - [SSRIs vs SNRIs - What's the difference between them?](https://www.drugs.com/medical-answers/difference-between-ssris-snris-3504539/) - [How long do venlafaxine withdrawal symptoms last?](https://www.drugs.com/medical-answers/long-venlafaxine-withdrawal-symptoms-3573466/) - [How long does Xanax last for / stay in your system?](https://www.drugs.com/medical-answers/long-xanax-3510962/) - [What does Prozac feel like when it starts working?](https://www.drugs.com/medical-answers/prozac-feel-starts-working-3571159/) - [Klonopin vs Xanax - How are they different?](https://www.drugs.com/medical-answers/klonopin-vs-xanax-3030557/) - [How long does Zoloft (sertraline) take to work?](https://www.drugs.com/medical-answers/long-zoloft-sertraline-work-3565128/) [View more FAQ](https://www.drugs.com/answers/support-group/depression/questions/?status=faq) ## Topics under Depression - [Depressive Psychosis](https://www.drugs.com/condition/depressive-psychosis.html) (2 drugs) - [Major Depressive Disorder](https://www.drugs.com/condition/major-depressive-disorder.html) (60 drugs) - [Major Depressive Disorder with Acute Suicidal Ideation](https://www.drugs.com/condition/depressive-disorder-other.html) (1 drug) - [Persistent Depressive Disorder](https://www.drugs.com/condition/dysthymia.html) (10 drugs in 2 topics) - [Postpartum Depression](https://www.drugs.com/condition/postpartum-depression.html) (14 drugs) - [Seasonal Affective Disorder](https://www.drugs.com/condition/seasonal-affective-disorder.html) (2 drugs) - [Sexual Dysfunction, SSRI Induced](https://www.drugs.com/condition/sexual-dysfunction-ssri-induced.html) (6 drugs) ## Alternative treatments for Depression The following products are considered to be alternative treatments or natural remedies for Depression. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However, there may be historical, cultural or anecdotal evidence linking their use to the treatment of Depression. - [5-HTP Mood and Stress](https://www.drugs.com/mtm/5-htp-mood-and-stress.html) - [Gotu kola](https://www.drugs.com/mtm/gotu-kola.html) - [Natrol SAMe](https://www.drugs.com/mtm/natrol-same.html) - [St. John's wort](https://www.drugs.com/mtm/st-john-s-wort.html) - [Tryptophan](https://www.drugs.com/tryptophan.html) - [Valerian](https://www.drugs.com/mtm/valerian.html) #### Legend \| \| \| \|---\|---\| \| Rating \| For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). \| \| Activity \| Activity is based on recent site visitor activity relative to other medications in the list. \| \| Rx \| Available for purchase by prescription only. \| \| OTC \| Available for purchase over-the-counter. \| \| Rx/OTC \| Available for purchase by prescription or over-the-counter. \| \| Alcohol \| The medication interacts with alcohol (if marked with "✕"). \| \| New approval \| The FDA has approved this medication within the past year. \| \| Off-label \| The FDA may not approve this medication for the treatment of this condition. \| \| EUA \| An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives. \| \| Expanded access \| Expanded access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available. \| \| Pregnancy Category \| \| \|---\|---\| \| A \| Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters). \| \| B \| Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. \| \| C \| Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| D \| There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. \| \| ✕ \| Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits. \| \| N \| FDA has not classified the drug. \| \| Controlled Substances Act (CSA) Schedule \| \| \|---\|---\| \| M \| The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication. \| \| U \| CSA Schedule is unknown. \| \| N \| Is not subject to the Controlled Substances Act. \| \| 1 \| Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. \| \| 2 \| Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence. \| \| 3 \| Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence. \| \| 4 \| Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3. \| \| 5 \| Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4. \| ### Browse treatment options - [A](https://www.drugs.com/condition/a.html) - [B](https://www.drugs.com/condition/b.html) - [C](https://www.drugs.com/condition/c.html) - [D](https://www.drugs.com/condition/d.html) - [E](https://www.drugs.com/condition/e.html) - [F](https://www.drugs.com/condition/f.html) - [G](https://www.drugs.com/condition/g.html) - [H](https://www.drugs.com/condition/h.html) - [I](https://www.drugs.com/condition/i.html) - [J](https://www.drugs.com/condition/j.html) - [K](https://www.drugs.com/condition/k.html) - [L](https://www.drugs.com/condition/l.html) - [M](https://www.drugs.com/condition/m.html) - [N](https://www.drugs.com/condition/n.html) - [O](https://www.drugs.com/condition/o.html) - [P](https://www.drugs.com/condition/p.html) - [Q](https://www.drugs.com/condition/q.html) - [R](https://www.drugs.com/condition/r.html) - [S](https://www.drugs.com/condition/s.html) - [T](https://www.drugs.com/condition/t.html) - [U](https://www.drugs.com/condition/u.html) - [V](https://www.drugs.com/condition/v.html) - [W](https://www.drugs.com/condition/w.html) - [X](https://www.drugs.com/condition/x.html) - [Y](https://www.drugs.com/condition/y.html) - [Z](https://www.drugs.com/condition/z.html) ## Further information Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. 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