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Amitriptyline
Pronunciation:
a-mee-TRIP-ti-leen
Brand names:
Elavil
, Endep,
Vanatrip
Dosage form:
tablets (10mg, 25mg, 50mg, 75mg, 100mg, 150mg)
Drug class:
Tricyclic antidepressants
Uses
Side effects
Warnings
Before taking
Dosage
Interactions
FAQ
What is amitriptyline?
Amitriptyline is a tricyclic
antidepressant
used to treat
depression
and used off-label for
insomnia
,
migraine prevention
, ADHD, eating disorders, bipolar disorder, anxiety, psychotic disorders, and
nerve pain
. Amitriptyline works by increasing serotonin and norepinephrine, natural chemicals in the brain that help regulate mood, pain, and symptoms of other conditions.Â
Amitriptyline is from the drug class
tricyclic antidepressants
(TCA).
Amitriptyline brand names were Elavil, Vanatrip, and Endep, which have been discontinued. Amitriptyline is now available as a generic medication. Amitriptyline is available in combination with chlordiazepoxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.Â
Amitriptyline side effects
Common amitriptyline side effects
Common amitriptyline side effects may include dry mouth, vision changes, sleepiness (sedation), tiredness, appetite or weight changes, constipation,
diarrhea
, nausea,
vomiting
,
upset stomach
, mouth pain, unusual taste, black tongue, urinating less than usual, breast swelling (in men or women), lower sex drive,
impotence
, or difficulty having an orgasm.
Serious amitriptyline side effects
Allergic reactions: Get emergency medical help if you have signs of an allergic reaction to amitriptyline, including difficulty breathing, hives, or swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as mood or behavior changes,
anxiety
,
panic attacks
, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Amitriptyline can cause other serious side effects. Call your doctor at once if you have:
signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg;
unusual thoughts or behavior;
a light-headed feeling, like you might pass out;
chest pain or pressure, pain spreading to your jaw or shoulder,
nausea
, sweating;
pounding heartbeats or fluttering in your chest;
confusion, hallucinations;
a seizure (convulsions);
painful or difficult urination;
severe
constipation
;
easy bruising, unusual bleeding, or
fever, chills,
sore throat
, and mouth sores.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Warnings
Boxed warning for suicidality. Antidepressants may increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18â24 years of age) with major depressive disorder and other psychiatric disorders. It is important to balance this risk with clinical need. Amitriptyline is not approved for use in pediatric patients less than 12 years of age. You may have thoughts about suicide when you first start taking an antidepressant such as amitriptyline, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. For full Boxed Warning details see the
Prescribing Information.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
You should not use amitriptyline if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days, such as
isocarboxazid
,
linezolid
,
methylene blue
injection,
phenelzine
,
rasagiline
,
selegiline
, or
tranylcypromine
.
Amitriptyline may trigger an angle closure glaucoma attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
Before taking this medicine
You should not use this medicine if you are allergic to amitriptyline or any of the inactive ingredients or:
if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as
citalopram
,
escitalopram
,
fluoxetine
(
Prozac
),
fluvoxamine
,
paroxetine
,
sertraline
(
Zoloft
),
trazodone
, or
vilazodone
.
To make sure amitriptyline is safe for you, tell your doctor if you have ever had:
bipolar disorder
(manic-depression) or
schizophrenia
;
mental illness or psychosis;
liver disease;
heart disease;
a heart attack, stroke, or
seizures
;
diabetes (amitriptyline may raise or lower blood sugar);
glaucoma
; or
problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
Amitriptyline is not approved for use by anyone younger than 12 years old.
How should I take amitriptyline?
Take amitriptyline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
If you need surgery, tell your surgeon you currently use amitriptyline. You may need to stop for a short time.
Do not stop using amitriptyline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using amitriptyline.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Amitriptyline dosing information
Usual Adult Amitriptyline Dose for Depression:
Outpatients:Â
Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed)
Maintenance dose: 40 to 100 mg orally per day
Maximum dose: 150 mg/day
Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day
Inpatients:
Initial dose: 100 mg orally per day
Maintenance dose: 40 to 100 mg orally as a single dose at bedtime
Maximum dose: 300 mg/day
Comments:
Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect.
The full therapeutic effect may take as long as 30 days to develop.
Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained.
Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse.
Usual Geriatric Dose for Depression:
Dose:
10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
Comments:
The full therapeutic effect may take as long as 30 days to develop.
Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate.
Dose adjustments should be made according to clinical response.
Usual Pediatric Dose for Depression:
Aimitripyline dose 12 years or older:
10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
Comments:
The full therapeutic effect may take as long as 30 days to develop.
Dose adjustments should be made according to clinical response.
Available as
amitriptyline 10mg tablets, amitriptyline 25mg tablets, 50mg tablets, 75mg tablets 100mg tablets and 150mg tablets.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
An overdose of amitriptyline can be fatal.
Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.
What to avoid
Do not drink alcohol.
Dangerous side effects or death can occur when alcohol is combined with amitriptyline.
Avoid driving or hazardous activity until you know how amitriptyline will affect you. Your reactions could be impaired.
Avoid exposure to sunlight or tanning beds. Amitriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
What other drugs will affect amitriptyline?
Taking amitriptyline with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking amitriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your other medicines, especially:
other
antidepressants
;
medicine to treat depression, anxiety, mood disorders, or mental illness;
cold or allergy medicine (Benadryl and others);
medicine to treat
Parkinson's disease
;
medicine to treat stomach problems,
motion sickness
, or
irritable bowel syndrome
;
medicine to treat
overactive bladder
; or
bronchodilator
asthma
medication.
This list is not complete. Other drugs may affect amitriptyline, including prescription and over-the-counter medicines,
vitamins
, and
herbal products
. Not all possible drug interactions are listed here.
Does Amitriptyline interact with my other drugs?
Enter medications to view a detailed interaction report using our
Drug Interaction Checker
.
Storage
Store at 20-25ÂșC (68 -77ÂșF); excursions permitted to 15-30 ÂșC (59-86 ÂșF). [See USP Controlled Room Temperature].
Popular FAQ
What drugs can cause serotonin syndrome?
Common drug classes that can cause serotonin syndrome include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and opioids like tramadol.
Continue reading
How long does amitriptyline take to work?
It typically takes 2-4 weeks for amitriptyline to work. However, the time it takes for the medication to work depends on what condition it's being used to treat and other factors. Amitriptyline is a prescription medication commonly used to treat depression, chronic pain, migraines, and several other conditions.
Continue reading
Does amitriptyline cause weight gain?
Yes, weight gain has been reported as a common side effect with amitriptyline and may occur in 1% to 10% of patients. Amitriptyline is a tricyclic antidepressant (TCA) and other drugs in this class have been associated with weight gain. TCAs block histamine receptors which may be responsible for increased appetite and weight gain.
Continue reading
How long does amitriptyline stay in your system?
Amitriptyline can stay in your system for about 2 to 6 days after your last dose. Factors like your age, liver function, metabolism, and how long youâve been taking it can affect exactly how quickly it clears.
Continue reading
Does amitriptyline cause high blood pressure?
Yes, amitriptyline can cause high blood pressure (hypertension), but it is more commonly associated with causing low blood pressure (orthostatic hypotension). This is thought to be related to its mechanism of action, which involves increasing the levels of certain chemicals in the brain and nervous system.
Continue reading
Is amitriptyline addictive?
Amitriptyline is not addictive or habit-forming, but it may cause sudden withdrawal symptoms if you stop treatment abruptly. Side effects from rapid withdrawal can include headache, nausea, trouble sleeping, abnormal dreams, irritability, and restlessness. Talk to your doctor about the best way to stop treatment.
Continue reading
More FAQ
What are some common side effects of antidepressants?
View more FAQ
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amitriptyline only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Copyright 1996-2026 Cerner Multum, Inc. Version: 12.01. |
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# Amitriptyline
Play pronunciation
**Pronunciation:** *a-mee-TRIP-ti-leen*
**Brand names:** [Elavil](https://www.drugs.com/elavil.html), Endep, [Vanatrip](https://www.drugs.com/cons/vanatrip.html)
**Dosage form:** tablets (10mg, 25mg, 50mg, 75mg, 100mg, 150mg)
**Drug class:** [Tricyclic antidepressants](https://www.drugs.com/drug-class/tricyclic-antidepressants.html)
Medically reviewed by [Melisa Puckey, BPharm](https://www.drugs.com/support/editor/21/melisa-puckey-bpharm.html). Last updated on July 14, 2025.
- [Uses](https://www.drugs.com/amitriptyline.html#uses)
- [Side effects](https://www.drugs.com/amitriptyline.html#side-effects)
- [Warnings](https://www.drugs.com/amitriptyline.html#warnings)
- [Before taking](https://www.drugs.com/amitriptyline.html#before-taking)
- [Dosage](https://www.drugs.com/amitriptyline.html#dosage)
- [Interactions](https://www.drugs.com/amitriptyline.html#interactions)
- [FAQ](https://www.drugs.com/amitriptyline.html#faq)
## What is amitriptyline?
Amitriptyline is a tricyclic [antidepressant](https://www.drugs.com/drug-class/antidepressants.html) used to treat [depression](https://www.drugs.com/condition/depression.html) and used off-label for [insomnia](https://www.drugs.com/condition/insomnia.html), [migraine prevention](https://www.drugs.com/condition/migraine-prophylaxis.html), ADHD, eating disorders, bipolar disorder, anxiety, psychotic disorders, and [nerve pain](https://www.drugs.com/condition/neuralgia.html). Amitriptyline works by increasing serotonin and norepinephrine, natural chemicals in the brain that help regulate mood, pain, and symptoms of other conditions.
Amitriptyline is from the drug class [tricyclic antidepressants](https://www.drugs.com/drug-class/tricyclic-antidepressants.html) (TCA).
Amitriptyline brand names were Elavil, Vanatrip, and Endep, which have been discontinued. Amitriptyline is now available as a generic medication. Amitriptyline is available in combination with chlordiazepoxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
## Amitriptyline side effects
### Common amitriptyline side effects
Common amitriptyline side effects may include dry mouth, vision changes, sleepiness (sedation), tiredness, appetite or weight changes, constipation, [diarrhea](https://www.drugs.com/cg/acute-diarrhea.html), nausea, [vomiting](https://www.drugs.com/cg/acute-nausea-and-vomiting.html), [upset stomach](https://www.drugs.com/cg/acute-nausea-and-vomiting.html), mouth pain, unusual taste, black tongue, urinating less than usual, breast swelling (in men or women), lower sex drive, [impotence](https://www.drugs.com/cg/erectile-dysfunction.html), or difficulty having an orgasm.
### Serious amitriptyline side effects
Allergic reactions: Get emergency medical help if you have signs of an allergic reaction to amitriptyline, including difficulty breathing, hives, or swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as mood or behavior changes, [anxiety](https://www.drugs.com/cg/anxiety.html), [panic attacks](https://www.drugs.com/cg/panic-disorder.html), trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Amitriptyline can cause other serious side effects. Call your doctor at once if you have:
- signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg;
- unusual thoughts or behavior;
- a light-headed feeling, like you might pass out;
- chest pain or pressure, pain spreading to your jaw or shoulder, [nausea](https://www.drugs.com/health-guide/nausea.html), sweating;
- pounding heartbeats or fluttering in your chest;
- confusion, hallucinations;
- a seizure (convulsions);
- painful or difficult urination;
- severe [constipation](https://www.drugs.com/cg/constipation.html);
- easy bruising, unusual bleeding, or
- fever, chills, [sore throat](https://www.drugs.com/cg/sore-throat-in-children.html), and mouth sores.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
[Amitriptyline side effects](https://www.drugs.com/sfx/amitriptyline-side-effects.html) (more detail)
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## Warnings
Boxed warning for suicidality. Antidepressants may increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18â24 years of age) with major depressive disorder and other psychiatric disorders. It is important to balance this risk with clinical need. Amitriptyline is not approved for use in pediatric patients less than 12 years of age. You may have thoughts about suicide when you first start taking an antidepressant such as amitriptyline, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. For full Boxed Warning details see the [Prescribing Information.](https://www.drugs.com/pro/amitriptyline.html)
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
You should not use amitriptyline if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days, such as [isocarboxazid](https://www.drugs.com/mtm/isocarboxazid.html), [linezolid](https://www.drugs.com/mtm/linezolid-oral-injection.html), [methylene blue](https://www.drugs.com/mtm/methylene-blue-injection.html) injection, [phenelzine](https://www.drugs.com/mtm/phenelzine.html), [rasagiline](https://www.drugs.com/mtm/rasagiline.html), [selegiline](https://www.drugs.com/mtm/selegiline.html), or [tranylcypromine](https://www.drugs.com/mtm/tranylcypromine.html).
Amitriptyline may trigger an angle closure glaucoma attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
[Starting Amitriptyline? Read this first](https://www.drugs.com/tips/amitriptyline-patient-tips)
## Before taking this medicine
You should not use this medicine if you are allergic to amitriptyline or any of the inactive ingredients or:
- if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as [citalopram](https://www.drugs.com/citalopram.html), [escitalopram](https://www.drugs.com/escitalopram.html), [fluoxetine](https://www.drugs.com/fluoxetine.html) ([Prozac](https://www.drugs.com/prozac.html)), [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html), [paroxetine](https://www.drugs.com/paroxetine.html), [sertraline](https://www.drugs.com/sertraline.html) ([Zoloft](https://www.drugs.com/zoloft.html)), [trazodone](https://www.drugs.com/trazodone.html), or [vilazodone](https://www.drugs.com/mtm/vilazodone.html).
To make sure amitriptyline is safe for you, tell your doctor if you have ever had:
- [bipolar disorder](https://www.drugs.com/cg/bipolar-disorder.html) (manic-depression) or [schizophrenia](https://www.drugs.com/cg/schizophrenia.html);
- mental illness or psychosis;
- liver disease;
- heart disease;
- a heart attack, stroke, or [seizures](https://www.drugs.com/cg/frontal-lobe-seizures.html);
- diabetes (amitriptyline may raise or lower blood sugar);
- [glaucoma](https://www.drugs.com/cg/glaucoma.html); or
- problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
Amitriptyline is not approved for use by anyone younger than 12 years old.
[Amitriptyline pregnancy and breastfeeding warnings](https://www.drugs.com/pregnancy/amitriptyline.html) (more detail)
## How should I take amitriptyline?
Take amitriptyline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
If you need surgery, tell your surgeon you currently use amitriptyline. You may need to stop for a short time.
Do not stop using amitriptyline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using amitriptyline.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
## Amitriptyline dosing information
### Usual Adult Amitriptyline Dose for Depression:
**Outpatients:**
- Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed)
- Maintenance dose: 40 to 100 mg orally per day
- Maximum dose: 150 mg/day
- Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day
**Inpatients:**
- Initial dose: 100 mg orally per day
- Maintenance dose: 40 to 100 mg orally as a single dose at bedtime
- Maximum dose: 300 mg/day
**Comments:**
- Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect.
- The full therapeutic effect may take as long as 30 days to develop.
- Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained.
- Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse.
### Usual Geriatric Dose for Depression:
**Dose:** 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
**Comments:**
- The full therapeutic effect may take as long as 30 days to develop.
- Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate.
- Dose adjustments should be made according to clinical response.
### Usual Pediatric Dose for Depression:
**Aimitripyline dose 12 years or older:** 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
**Comments:**
- The full therapeutic effect may take as long as 30 days to develop.
- Dose adjustments should be made according to clinical response.
**Available as** amitriptyline 10mg tablets, amitriptyline 25mg tablets, 50mg tablets, 75mg tablets 100mg tablets and 150mg tablets.
[Detailed Amitriptyline dosage information](https://www.drugs.com/dosage/amitriptyline.html)
## What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
## What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. **An overdose of amitriptyline can be fatal.**
Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.
## What to avoid
**Do not drink alcohol.** Dangerous side effects or death can occur when alcohol is combined with amitriptyline.
Avoid driving or hazardous activity until you know how amitriptyline will affect you. Your reactions could be impaired.
Avoid exposure to sunlight or tanning beds. Amitriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
## What other drugs will affect amitriptyline?
Taking amitriptyline with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking amitriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your other medicines, especially:
- other [antidepressants](https://www.drugs.com/drug-class/antidepressants.html);
- medicine to treat depression, anxiety, mood disorders, or mental illness;
- cold or allergy medicine (Benadryl and others);
- medicine to treat [Parkinson's disease](https://www.drugs.com/cg/parkinson-disease.html);
- medicine to treat stomach problems, [motion sickness](https://www.drugs.com/cg/motion-sickness.html), or [irritable bowel syndrome](https://www.drugs.com/cg/irritable-bowel-syndrome.html);
- medicine to treat [overactive bladder](https://www.drugs.com/cg/overactive-bladder.html); or
- bronchodilator [asthma](https://www.drugs.com/cg/asthma.html) medication.
This list is not complete. Other drugs may affect amitriptyline, including prescription and over-the-counter medicines, [vitamins](https://www.drugs.com/drug-class/vitamins.html), and [herbal products](https://www.drugs.com/drug-class/herbal-products.html). Not all possible drug interactions are listed here.
[Amitriptyline drug interactions](https://www.drugs.com/drug-interactions/amitriptyline.html) (more detail)
### Does Amitriptyline interact with my other drugs?
Enter medications to view a detailed interaction report using our [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html).
## Storage
Store at 20-25ÂșC (68 -77ÂșF); excursions permitted to 15-30 ÂșC (59-86 ÂșF). \[See USP Controlled Room Temperature\].
## Popular FAQ
What drugs can cause serotonin syndrome?
Common drug classes that can cause serotonin syndrome include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and opioids like tramadol.
[Continue reading](https://www.drugs.com/medical-answers/what-drugs-cause-serotonin-syndrome-3580100/)
How long does amitriptyline take to work?
It typically takes 2-4 weeks for amitriptyline to work. However, the time it takes for the medication to work depends on what condition it's being used to treat and other factors. Amitriptyline is a prescription medication commonly used to treat depression, chronic pain, migraines, and several other conditions.
[Continue reading](https://www.drugs.com/medical-answers/long-amitriptyline-work-3568883/)
Does amitriptyline cause weight gain?
Yes, weight gain has been reported as a common side effect with amitriptyline and may occur in 1% to 10% of patients. Amitriptyline is a tricyclic antidepressant (TCA) and other drugs in this class have been associated with weight gain. TCAs block histamine receptors which may be responsible for increased appetite and weight gain.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-weight-gain-3567907/)
How long does amitriptyline stay in your system?
Amitriptyline can stay in your system for about 2 to 6 days after your last dose. Factors like your age, liver function, metabolism, and how long youâve been taking it can affect exactly how quickly it clears.
[Continue reading](https://www.drugs.com/medical-answers/long-amitriptyline-stay-system-3569063/)
Does amitriptyline cause high blood pressure?
Yes, amitriptyline can cause high blood pressure (hypertension), but it is more commonly associated with causing low blood pressure (orthostatic hypotension). This is thought to be related to its mechanism of action, which involves increasing the levels of certain chemicals in the brain and nervous system.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-high-blood-pressure-3568740/)
Is amitriptyline addictive?
Amitriptyline is not addictive or habit-forming, but it may cause sudden withdrawal symptoms if you stop treatment abruptly. Side effects from rapid withdrawal can include headache, nausea, trouble sleeping, abnormal dreams, irritability, and restlessness. Talk to your doctor about the best way to stop treatment.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-addictive-3571356/)
### More FAQ
- [What are some common side effects of antidepressants?](https://www.drugs.com/medical-answers/common-side-effects-antidepressants-3440087/)
[View more FAQ](https://www.drugs.com/answers/support-group/amitriptyline/questions/?status=faq)
## References
1. [Amitriptyline Hydrochloride tablets](https://www.accessdata.fda.gov/spl/data/0f12f50f-7087-46e7-a2e6-356b4c566c9f/0f12f50f-7087-46e7-a2e6-356b4c566c9f.xml)
2. [Amitriptyline Medication Guide](https://www.risingpharma.com/Medguides/AmitriptylineTabletsUSPMG.pdf)
## More about amitriptyline
- [Check interactions](https://www.drugs.com/drug-interactions/amitriptyline.html)
- [Compare alternatives](https://www.drugs.com/compare/amitriptyline)
- [Pricing & coupons](https://www.drugs.com/price-guide/amitriptyline)
- [Reviews (1,827)](https://www.drugs.com/comments/amitriptyline/)
- [Drug images](https://www.drugs.com/image/amitriptyline-images.html)
- [Side effects](https://www.drugs.com/sfx/amitriptyline-side-effects.html)
- [Dosage information](https://www.drugs.com/dosage/amitriptyline.html)
- [Patient tips](https://www.drugs.com/tips/amitriptyline-patient-tips)
- [During pregnancy](https://www.drugs.com/pregnancy/amitriptyline.html)
- [Support group](https://www.drugs.com/answers/support-group/amitriptyline/)
- [Drug class: tricyclic antidepressants](https://www.drugs.com/drug-class/tricyclic-antidepressants.html)
- [Breastfeeding](https://www.drugs.com/breastfeeding/amitriptyline.html)
- [En español](https://www.drugs.com/mtm_esp/amitriptyline.html)
### Patient resources
#### Other brands
[Elavil](https://www.drugs.com/elavil.html), [Vanatrip](https://www.drugs.com/cons/vanatrip.html)
### Professional resources
- [Amitriptyline monograph](https://www.drugs.com/monograph/amitriptyline.html)
- [Amitriptyline (FDA)](https://www.drugs.com/pro/amitriptyline.html)
#### Other brands
[Elavil](https://www.drugs.com/pro/elavil.html)
### Related treatment guides
- [Chronic Pain](https://www.drugs.com/condition/chronic-pain.html)
- [Anxiety and Stress](https://www.drugs.com/condition/anxiety-stress.html)
- [Chronic Myofascial Pain](https://www.drugs.com/condition/chronic-myofascial-pain.html)
- [Burning Mouth Syndrome](https://www.drugs.com/condition/burning-mouth-syndrome.html)
## Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amitriptyline only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
[Medical Disclaimer](https://www.drugs.com/support/disclaimer.html)
Copyright 1996-2026 Cerner Multum, Inc. Version: 12.01.
**Drug Status**
**Availability** Prescription only Rx
[**Pregnancy & Lactation**](https://www.drugs.com/pregnancy/amitriptyline.html) Risk data available
**CSA Schedule\*** Not a controlled drug N/A
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**Approval History** Drug history at FDA
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User Reviews & Ratings
7\.5 / 10
[1,827 Reviews](https://www.drugs.com/comments/amitriptyline/)
Images
[ Amitriptyline Hydrochloride 25 mg (U 420)](https://www.drugs.com/imprints/u-420-31730.html "View larger image")
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| Readable Markdown | 1. [Home](https://www.drugs.com/)
2. Amitriptyline
**Pronunciation:** *a-mee-TRIP-ti-leen*
**Brand names:** [Elavil](https://www.drugs.com/elavil.html), Endep, [Vanatrip](https://www.drugs.com/cons/vanatrip.html)
**Dosage form:** tablets (10mg, 25mg, 50mg, 75mg, 100mg, 150mg)
**Drug class:** [Tricyclic antidepressants](https://www.drugs.com/drug-class/tricyclic-antidepressants.html)
- [Uses](https://www.drugs.com/amitriptyline.html#uses)
- [Side effects](https://www.drugs.com/amitriptyline.html#side-effects)
- [Warnings](https://www.drugs.com/amitriptyline.html#warnings)
- [Before taking](https://www.drugs.com/amitriptyline.html#before-taking)
- [Dosage](https://www.drugs.com/amitriptyline.html#dosage)
- [Interactions](https://www.drugs.com/amitriptyline.html#interactions)
- [FAQ](https://www.drugs.com/amitriptyline.html#faq)
## What is amitriptyline?
Amitriptyline is a tricyclic [antidepressant](https://www.drugs.com/drug-class/antidepressants.html) used to treat [depression](https://www.drugs.com/condition/depression.html) and used off-label for [insomnia](https://www.drugs.com/condition/insomnia.html), [migraine prevention](https://www.drugs.com/condition/migraine-prophylaxis.html), ADHD, eating disorders, bipolar disorder, anxiety, psychotic disorders, and [nerve pain](https://www.drugs.com/condition/neuralgia.html). Amitriptyline works by increasing serotonin and norepinephrine, natural chemicals in the brain that help regulate mood, pain, and symptoms of other conditions.
Amitriptyline is from the drug class [tricyclic antidepressants](https://www.drugs.com/drug-class/tricyclic-antidepressants.html) (TCA).
Amitriptyline brand names were Elavil, Vanatrip, and Endep, which have been discontinued. Amitriptyline is now available as a generic medication. Amitriptyline is available in combination with chlordiazepoxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
## Amitriptyline side effects
### Common amitriptyline side effects
Common amitriptyline side effects may include dry mouth, vision changes, sleepiness (sedation), tiredness, appetite or weight changes, constipation, [diarrhea](https://www.drugs.com/cg/acute-diarrhea.html), nausea, [vomiting](https://www.drugs.com/cg/acute-nausea-and-vomiting.html), [upset stomach](https://www.drugs.com/cg/acute-nausea-and-vomiting.html), mouth pain, unusual taste, black tongue, urinating less than usual, breast swelling (in men or women), lower sex drive, [impotence](https://www.drugs.com/cg/erectile-dysfunction.html), or difficulty having an orgasm.
### Serious amitriptyline side effects
Allergic reactions: Get emergency medical help if you have signs of an allergic reaction to amitriptyline, including difficulty breathing, hives, or swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as mood or behavior changes, [anxiety](https://www.drugs.com/cg/anxiety.html), [panic attacks](https://www.drugs.com/cg/panic-disorder.html), trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Amitriptyline can cause other serious side effects. Call your doctor at once if you have:
- signs of a blood clot - sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg;
- unusual thoughts or behavior;
- a light-headed feeling, like you might pass out;
- chest pain or pressure, pain spreading to your jaw or shoulder, [nausea](https://www.drugs.com/health-guide/nausea.html), sweating;
- pounding heartbeats or fluttering in your chest;
- confusion, hallucinations;
- a seizure (convulsions);
- painful or difficult urination;
- severe [constipation](https://www.drugs.com/cg/constipation.html);
- easy bruising, unusual bleeding, or
- fever, chills, [sore throat](https://www.drugs.com/cg/sore-throat-in-children.html), and mouth sores.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
## Warnings
Boxed warning for suicidality. Antidepressants may increase the risk of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults (18â24 years of age) with major depressive disorder and other psychiatric disorders. It is important to balance this risk with clinical need. Amitriptyline is not approved for use in pediatric patients less than 12 years of age. You may have thoughts about suicide when you first start taking an antidepressant such as amitriptyline, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment. For full Boxed Warning details see the [Prescribing Information.](https://www.drugs.com/pro/amitriptyline.html)
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
You should not use amitriptyline if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days, such as [isocarboxazid](https://www.drugs.com/mtm/isocarboxazid.html), [linezolid](https://www.drugs.com/mtm/linezolid-oral-injection.html), [methylene blue](https://www.drugs.com/mtm/methylene-blue-injection.html) injection, [phenelzine](https://www.drugs.com/mtm/phenelzine.html), [rasagiline](https://www.drugs.com/mtm/rasagiline.html), [selegiline](https://www.drugs.com/mtm/selegiline.html), or [tranylcypromine](https://www.drugs.com/mtm/tranylcypromine.html).
Amitriptyline may trigger an angle closure glaucoma attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
## Before taking this medicine
You should not use this medicine if you are allergic to amitriptyline or any of the inactive ingredients or:
- if you have recently had a heart attack.
Do not use amitriptyline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as [citalopram](https://www.drugs.com/citalopram.html), [escitalopram](https://www.drugs.com/escitalopram.html), [fluoxetine](https://www.drugs.com/fluoxetine.html) ([Prozac](https://www.drugs.com/prozac.html)), [fluvoxamine](https://www.drugs.com/mtm/fluvoxamine.html), [paroxetine](https://www.drugs.com/paroxetine.html), [sertraline](https://www.drugs.com/sertraline.html) ([Zoloft](https://www.drugs.com/zoloft.html)), [trazodone](https://www.drugs.com/trazodone.html), or [vilazodone](https://www.drugs.com/mtm/vilazodone.html).
To make sure amitriptyline is safe for you, tell your doctor if you have ever had:
- [bipolar disorder](https://www.drugs.com/cg/bipolar-disorder.html) (manic-depression) or [schizophrenia](https://www.drugs.com/cg/schizophrenia.html);
- mental illness or psychosis;
- liver disease;
- heart disease;
- a heart attack, stroke, or [seizures](https://www.drugs.com/cg/frontal-lobe-seizures.html);
- diabetes (amitriptyline may raise or lower blood sugar);
- [glaucoma](https://www.drugs.com/cg/glaucoma.html); or
- problems with urination.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Tell your doctor if you are pregnant or breastfeeding.
Amitriptyline is not approved for use by anyone younger than 12 years old.
## How should I take amitriptyline?
Take amitriptyline exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
If you need surgery, tell your surgeon you currently use amitriptyline. You may need to stop for a short time.
Do not stop using amitriptyline suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using amitriptyline.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
## Amitriptyline dosing information
### Usual Adult Amitriptyline Dose for Depression:
**Outpatients:**
- Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed)
- Maintenance dose: 40 to 100 mg orally per day
- Maximum dose: 150 mg/day
- Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day
**Inpatients:**
- Initial dose: 100 mg orally per day
- Maintenance dose: 40 to 100 mg orally as a single dose at bedtime
- Maximum dose: 300 mg/day
**Comments:**
- Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect.
- The full therapeutic effect may take as long as 30 days to develop.
- Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained.
- Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse.
### Usual Geriatric Dose for Depression:
**Dose:** 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
**Comments:**
- The full therapeutic effect may take as long as 30 days to develop.
- Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate.
- Dose adjustments should be made according to clinical response.
### Usual Pediatric Dose for Depression:
**Aimitripyline dose 12 years or older:** 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime
**Comments:**
- The full therapeutic effect may take as long as 30 days to develop.
- Dose adjustments should be made according to clinical response.
**Available as** amitriptyline 10mg tablets, amitriptyline 25mg tablets, 50mg tablets, 75mg tablets 100mg tablets and 150mg tablets.
## What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
## What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. **An overdose of amitriptyline can be fatal.**
Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.
## What to avoid
**Do not drink alcohol.** Dangerous side effects or death can occur when alcohol is combined with amitriptyline.
Avoid driving or hazardous activity until you know how amitriptyline will affect you. Your reactions could be impaired.
Avoid exposure to sunlight or tanning beds. Amitriptyline can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
## What other drugs will affect amitriptyline?
Taking amitriptyline with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking amitriptyline with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your other medicines, especially:
- other [antidepressants](https://www.drugs.com/drug-class/antidepressants.html);
- medicine to treat depression, anxiety, mood disorders, or mental illness;
- cold or allergy medicine (Benadryl and others);
- medicine to treat [Parkinson's disease](https://www.drugs.com/cg/parkinson-disease.html);
- medicine to treat stomach problems, [motion sickness](https://www.drugs.com/cg/motion-sickness.html), or [irritable bowel syndrome](https://www.drugs.com/cg/irritable-bowel-syndrome.html);
- medicine to treat [overactive bladder](https://www.drugs.com/cg/overactive-bladder.html); or
- bronchodilator [asthma](https://www.drugs.com/cg/asthma.html) medication.
This list is not complete. Other drugs may affect amitriptyline, including prescription and over-the-counter medicines, [vitamins](https://www.drugs.com/drug-class/vitamins.html), and [herbal products](https://www.drugs.com/drug-class/herbal-products.html). Not all possible drug interactions are listed here.
### Does Amitriptyline interact with my other drugs?
Enter medications to view a detailed interaction report using our [Drug Interaction Checker](https://www.drugs.com/drug_interactions.html).
## Storage
Store at 20-25ÂșC (68 -77ÂșF); excursions permitted to 15-30 ÂșC (59-86 ÂșF). \[See USP Controlled Room Temperature\].
## Popular FAQ
What drugs can cause serotonin syndrome?
Common drug classes that can cause serotonin syndrome include selective serotonin reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), and opioids like tramadol.
[Continue reading](https://www.drugs.com/medical-answers/what-drugs-cause-serotonin-syndrome-3580100/)
How long does amitriptyline take to work?
It typically takes 2-4 weeks for amitriptyline to work. However, the time it takes for the medication to work depends on what condition it's being used to treat and other factors. Amitriptyline is a prescription medication commonly used to treat depression, chronic pain, migraines, and several other conditions.
[Continue reading](https://www.drugs.com/medical-answers/long-amitriptyline-work-3568883/)
Does amitriptyline cause weight gain?
Yes, weight gain has been reported as a common side effect with amitriptyline and may occur in 1% to 10% of patients. Amitriptyline is a tricyclic antidepressant (TCA) and other drugs in this class have been associated with weight gain. TCAs block histamine receptors which may be responsible for increased appetite and weight gain.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-weight-gain-3567907/)
How long does amitriptyline stay in your system?
Amitriptyline can stay in your system for about 2 to 6 days after your last dose. Factors like your age, liver function, metabolism, and how long youâve been taking it can affect exactly how quickly it clears.
[Continue reading](https://www.drugs.com/medical-answers/long-amitriptyline-stay-system-3569063/)
Does amitriptyline cause high blood pressure?
Yes, amitriptyline can cause high blood pressure (hypertension), but it is more commonly associated with causing low blood pressure (orthostatic hypotension). This is thought to be related to its mechanism of action, which involves increasing the levels of certain chemicals in the brain and nervous system.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-high-blood-pressure-3568740/)
Is amitriptyline addictive?
Amitriptyline is not addictive or habit-forming, but it may cause sudden withdrawal symptoms if you stop treatment abruptly. Side effects from rapid withdrawal can include headache, nausea, trouble sleeping, abnormal dreams, irritability, and restlessness. Talk to your doctor about the best way to stop treatment.
[Continue reading](https://www.drugs.com/medical-answers/amitriptyline-addictive-3571356/)
### More FAQ
- [What are some common side effects of antidepressants?](https://www.drugs.com/medical-answers/common-side-effects-antidepressants-3440087/)
[View more FAQ](https://www.drugs.com/answers/support-group/amitriptyline/questions/?status=faq)
## Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amitriptyline only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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