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| Boilerpipe Text | In a sudden turnabout, Pfizer and BioNTech today announced they were delaying the application process for an emergency use authorization (EUA) for their vaccine for children ages 6 months to 4 years old, and gathering more information on two and three doses of the vaccine. The announcement comes just days before the Food and Drug Administration (FDA) was set to consider the application, and a day after the Centers for Disease Control and Prevention (CDC) had told pediatric vaccine providers to ready themselves for a Feb 21 delivery date of the mRNA vaccine. "As part of its rolling submission, the company recently notified the agency of additional findings from its ongoing clinical trial," the FDA said in a statement . "Based on the agency's preliminary assessment, and to allow more time to evaluate additional data, we believe additional information regarding the ongoing evaluation of a third dose should be considered as part of our decision-making for potential authorization.” In December, Pfizer released data on two 3-microgram doses of the Pfizer-BioNTech vaccine in children 6 months to 4 years. In children 2 years and older, the reduced doses did not elicit a significant immune response, and the company suggested a third dose may be needed. Today in a statement Pfizer said an ongoing study of a third dose of vaccine administered 2 months after the primary series is "advancing at a rapid pace," and the companies will wait for the three-dose data, which they expect to have by early April , before applying for the EUA. The FDA meeting scheduled for Feb 15 has been delayed until further notice. Data: Protection drops 4 months after third dose Today in Morbidity and Mortality Weekly Report, scientists present new research showing that protection against Omicron hospitalizations and emergency department visits drops significantly by 4 months after a third booster dose but is overall still high. Using data from a multistate analysis of 241,204 emergency department encounters and 93,408 hospitalizations for COVID-19 from Aug 26, 2021, to Jan 22, 2022, the authors found vaccine effectiveness (VE) during the Omicron-predominant period was 87% against emergency department or urgent care (ED/UC) visits and 91% against hospitalization during the 2 months following a booster dose of vaccine. VE dropped to 66% and 78% against COVID-19–associated ED/UC visits and hospitalizations, respectively, at 4 months after a booster dose. The authors said the data mirror what has been seen in Israel. The CDC COVID Data Tracker shows that 64.3% of Americans are fully vaccinated against COVID-19, 75.8% have received at least one dose of vaccine, and 42.6% of fully vaccinated Americans have received a booster dose. In related news, the FDA today granted an EUA to bebtelovimab , Eli Lilly's monoclonal antibody, for the treatment of mild to moderate COVID-19 in adults and pediatric patients. Pediatric patients must be at least 12 years of age. Bebtelovimab is effective against infections caused by the Omicron variant, but it must be administered intravenously. Eli Lilly said yesterday that 600,000 courses of the treatment , worth $720 million, have already been made available for the federal government to distribute. Deaths increase in South The United States reported 147,416 new COVID-19 cases yesterday and 3,179 deaths, according to the Johns Hopkins COVID-19 tracker . The 7-day average of new daily cases is 218,688, with 2,613 daily deaths, according to the Washington Post tracker . Two-week COVID-19 death counts have more than doubled in Florida, Hawaii, Mississippi, South Carolina, and Virginia, according to an NBC News analysis of federal data. Twenty-three states have seen a greater than 25% increase in COVID-19 deaths over the past 2 weeks. UK notes rise in subvariant cases Meanwhile, in its latest update on SARS-CoV-2 variants today, the United Kingdom's Health Security Agency (HAS) said the proportion of BA.2 subvariant cases is increasing compared to the original Omicron variant. The rise is occurring against the backdrop of an overall decrease in cases. As of Feb 6, the proportion of BA.2 cases, as indicated by S-gene target positivity on PCR tests, in England is 18.7%, compared with 5.1% Jan 24, which HAS said suggests the growth rate is substantial. Based on limited sequences sampled, there are no confirmed BA.2 reinfections in those infected with the parent Omicron variant. And contact tracing data suggest the average time from symptom onset from a primary case to contacts is about a half day shorter for BA.2 than BA.1, which the HSA said might be contributing to BA.2's increased growth rate. In other global COVID-19 news: Hong Kong again today reported a record high for cases, with 1,323 more reported. Talks are under way with officials in mainland China about ways it could support Hong Kong's overburdened health system during the surge, according to Reuters . Germany's chancellor said today that the country is nearing the peak of its Omicron surge and that officials will begin lifting some restrictions next week, with an eye toward easing all of them in the spring. Australia's top officials yesterday accepted a recommendation from vaccine advisers that people need to receive booster doses to be considered fully vaccinated . However, it will consider international travelers to be fully vaccinated with a two-dose series. The World Health Organization (WHO) today announced that it has qualified its first monoclonal antibody, tocilizumab, an intravenous drug designed to inhibit the inflammatory response known to be high in critically ill COVID-19 patients. The drug is already authorized to treat arthritis in about 120 countries. The drug is expensive and supplies are short, but the WHO said more manufacturers are entering the market, with talks under way with Roche about easing access for low- and middle-income countries. The global total today climbed to 407,446,539 cases, and 5,785,805 people have died from their infections, according to the Johns Hopkins online dashboard . CIDRAP News Editor Lisa Schnirring contributed to this story. |
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# COVID-19 vaccine for kids under 5 delayed as Pfizer extends trial
Stephanie Soucheray \| News Reporter \| CIDRAP News
February 11, 2022
[COVID-19](https://www.cidrap.umn.edu/covid-19)


> US Navy, Brett McMinoway / Flickr cc
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In a sudden turnabout, Pfizer and BioNTech today announced they were delaying the application process for an emergency use authorization (EUA) for their vaccine for children ages 6 months to 4 years old, and gathering more information on two and three doses of the vaccine.
The announcement comes just days before the Food and Drug Administration (FDA) was set to consider the application, and a day after the Centers for Disease Control and Prevention (CDC) had told pediatric vaccine providers to ready themselves for a Feb 21 delivery date of the mRNA vaccine.
"As part of its rolling submission, the company recently notified the agency of additional findings from its ongoing clinical trial," the FDA said in a [statement](https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-postpones-advisory-committee-meeting-discuss-request-authorization "(opens in a new window)"). "Based on the agency's preliminary assessment, and to allow more time to evaluate additional data, we believe additional information regarding the ongoing evaluation of a third dose should be considered as part of our decision-making for potential authorization.”
In December, Pfizer released data on two 3-microgram doses of the Pfizer-BioNTech vaccine in children 6 months to 4 years. In children 2 years and older, the reduced doses did not elicit a significant immune response, and the company suggested a third dose may be needed.
Today in a statement Pfizer said an ongoing study of a third dose of vaccine administered 2 months after the primary series is "advancing at a rapid pace," and the companies will wait for the three-dose data, which they [expect to have by early April](https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-rolling-submission "(opens in a new window)"), before applying for the EUA.
The FDA meeting scheduled for Feb 15 has been delayed until further notice.
### Data: Protection drops 4 months after third dose
Today in *Morbidity and Mortality Weekly Report,* scientists present new research showing that protection against Omicron hospitalizations and emergency department visits drops significantly by 4 months after a third booster dose but is overall still high.
[Using data](https://www.cdc.gov/mmwr/volumes/71/wr/mm7107e2.htm "(opens in a new window)") from a multistate analysis of 241,204 emergency department encounters and 93,408 hospitalizations for COVID-19 from Aug 26, 2021, to Jan 22, 2022, the authors found vaccine effectiveness (VE) during the Omicron-predominant period was 87% against emergency department or urgent care (ED/UC) visits and 91% against hospitalization during the 2 months following a booster dose of vaccine.
VE dropped to 66% and 78% against COVID-19–associated ED/UC visits and hospitalizations, respectively, at 4 months after a booster dose. The authors said the data mirror what has been seen in Israel.
The CDC [COVID Data Tracker](https://covid.cdc.gov/covid-data-tracker/#vaccinations_vacc-total-admin-rate-total "(opens in a new window)") shows that 64.3% of Americans are fully vaccinated against COVID-19, 75.8% have received at least one dose of vaccine, and 42.6% of fully vaccinated Americans have received a booster dose.
In related news, the FDA today granted an [EUA to bebtelovimab](https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-new-monoclonal-antibody-treatment-covid-19-retains "(opens in a new window)"), Eli Lilly's monoclonal antibody, for the treatment of mild to moderate COVID-19 in adults and pediatric patients. Pediatric patients must be at least 12 years of age.
Bebtelovimab is effective against infections caused by the Omicron variant, but it must be administered intravenously. Eli Lilly said yesterday that [600,000 courses of the treatment](https://investor.lilly.com/news-releases/news-release-details/lilly-will-supply-600000-doses-bebtelovimab-us-government "(opens in a new window)"), worth \$720 million, have already been made available for the federal government to distribute.
### Deaths increase in South
The United States reported 147,416 new COVID-19 cases yesterday and 3,179 deaths, according to the Johns Hopkins COVID-19 [tracker](https://coronavirus.jhu.edu/data/cumulative-cases "(opens in a new window)").
The 7-day average of new daily cases is 218,688, with 2,613 daily deaths, according to the *Washington Post* [tracker](https://www.washingtonpost.com/graphics/2020/national/coronavirus-us-cases-deaths/?itid=hp_pandemic_gfx/?state=US&indicator=reported_cases "(opens in a new window)").
Two-week COVID-19 death counts have more than doubled in Florida, Hawaii, Mississippi, South Carolina, and Virginia, according to an [NBC News](https://www.nbcnews.com/news/all/covid-death-hot-spot-map-n1288947 "(opens in a new window)") analysis of federal data. Twenty-three states have seen a greater than 25% increase in COVID-19 deaths over the past 2 weeks.
### UK notes rise in subvariant cases
Meanwhile, in its latest [update](https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1054357/Technical-Briefing-36-11February2022_v2.pdf "(opens in a new window)") on SARS-CoV-2 variants today, the United Kingdom's Health Security Agency (HAS) said the proportion of BA.2 subvariant cases is increasing compared to the original Omicron variant. The rise is occurring against the backdrop of an overall decrease in cases.
As of Feb 6, the proportion of BA.2 cases, as indicated by S-gene target positivity on PCR tests, in England is 18.7%, compared with 5.1% Jan 24, which HAS said suggests the growth rate is substantial.
Based on limited sequences sampled, there are no confirmed BA.2 reinfections in those infected with the parent Omicron variant. And contact tracing data suggest the average time from symptom onset from a primary case to contacts is about a half day shorter for BA.2 than BA.1, which the HSA said might be contributing to BA.2's increased growth rate.
In other global COVID-19 news:
- Hong Kong again today reported a record high for cases, with [1,323](https://www.info.gov.hk/gia/general/202202/11/P2022021100675.htm?fontSize=1 "(opens in a new window)") more reported. Talks are under way with officials in mainland China about ways it could support Hong Kong's overburdened health system during the surge, according to [Reuters](https://www.reuters.com/world/china/china-pledges-support-hong-kong-amid-covid-surge-2022-02-11/ "(opens in a new window)").
- Germany's chancellor said today that the country is [nearing the peak](https://www.reuters.com/world/europe/germany-lift-some-restrictions-next-week-covid-peak-sight-2022-02-11/ "(opens in a new window)") of its Omicron surge and that officials will begin lifting some restrictions next week, with an eye toward easing all of them in the spring.
- Australia's top officials yesterday accepted a recommendation from vaccine advisers that people need to receive booster doses to be considered [fully vaccinated](https://www.reuters.com/world/asia-pacific/australians-told-get-covid-boosters-be-considered-fully-vaccinated-2022-02-11/ "(opens in a new window)"). However, it will consider international travelers to be fully vaccinated with a two-dose series.
- The World Health Organization (WHO) today [announced](https://www.who.int/news/item/11-02-2022-who-prequalifies-first-monoclonal-antibody---tocilizumab-to-treat-covid-19 "(opens in a new window)") that it has qualified its first monoclonal antibody, tocilizumab, an intravenous drug designed to inhibit the inflammatory response known to be high in critically ill COVID-19 patients. The drug is already authorized to treat arthritis in about 120 countries. The drug is expensive and supplies are short, but the WHO said more manufacturers are entering the market, with talks under way with Roche about easing access for low- and middle-income countries.
- The global total today climbed to 407,446,539 cases, and 5,785,805 people have died from their infections, according to the Johns Hopkins [online dashboard](https://coronavirus.jhu.edu/ "(opens in a new window)").
*CIDRAP News Editor Lisa Schnirring contributed to this story.*
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