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URLhttps://www.cepheid.com/en-US/solutions/knowing-more-matters/pcr-vs-antigen.html
Last Crawled2026-04-20 13:31:09 (2 days ago)
First Indexed2024-09-10 22:44:18 (1 year ago)
HTTP Status Code200
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Meta TitlePCR Tests vs. Antigen Tests
Meta DescriptionA PCR or polymerase chain reaction test detects genetic material from an organism by copying a small portion of the genetic material in a process called amplification. Learn how PCR tests differ from antigen tests.
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A PCR (polymerase chain reaction) test detects genetic material from an organism (i.e. bacteria or a virus) by copying a small portion of the genetic material in a process called amplification. Amplification allows for easier detection and identification of pathogens (disease-causing organisms) — sometimes even prior to symptoms surfacing — thus helping to prevent the transmission of infection and halt further disease spread. Tests that do not use amplification, such as antigen tests, might not achieve early detection because there are not enough viruses, bacteria, or other pathogens present in a patient’s sample. 1. A patient gives a sample A healthcare provider takes a sample of blood, saliva, mucus, or tissue. This sample contains DNA or RNA (genetic material). 2. The sample is placed into a machine 
where PCR amplification occurs A chemical reaction causes the sample to make billions of copies 
of the genetic sequence. 3. The test is complete The machine determines if pathogens are present in the amplified sample. 
A healthcare professional examines the results to develop a treatment plan. What is the Difference Between PCR and Antigen Testing? Throughout the COVID-19 pandemic, both PCR and rapid antigen testing emerged as integral to slowing the spread of the virus. However, PCR has been recognized as the gold standard for respiratory virus testing. PCR Tests PCR tests are more sensitive than antigen tests. PCR tests amplify genetic material from the virus; therefore, they can detect very small amounts of virus in a sample Antigen Tests Antigen tests detect viral proteins directly from a sample without amplification; therefore, false negatives may occur if there is a low or moderate amount of virus present
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' for "' : ''}}{{searchText}}{{searchText ? '"' : ''}} What are PCR Tests? ![]() [Learn more about our fight to End TB and our Global Access program](https://www.cepheid.com/en-US/solutions/global-access.html) A PCR (polymerase chain reaction) test detects genetic material from an organism (i.e. bacteria or a virus) by copying a small portion of the genetic material in a process called amplification. Amplification allows for easier detection and identification of pathogens (disease-causing organisms) — sometimes even prior to symptoms surfacing — thus helping to prevent the transmission of infection and halt further disease spread. Tests that do not use amplification, such as antigen tests, might not achieve early detection because there are not enough viruses, bacteria, or other pathogens present in a patient’s sample. ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Knowing%20More%20Matters%20Banner%20PCR%20Use.png) ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Mobile%20PCR%20vs%20Antigen.png) ## How Does PCR Testing Work?2 ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon1PCR.png) **1\. A patient gives a sample** A healthcare provider takes a sample of blood, saliva, mucus, or tissue. This sample contains DNA or RNA (genetic material). ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon2PCR.png) **2\. The sample is placed into a machine where PCR amplification occurs** A chemical reaction causes the sample to make billions of copies of the genetic sequence. ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon3PCR.png) **3\. The test is complete** The machine determines if pathogens are present in the amplified sample. A healthcare professional examines the results to develop a treatment plan. What is the Difference Between PCR and Antigen Testing? Throughout the COVID-19 pandemic, both PCR and rapid antigen testing emerged as integral to slowing the spread of the virus. However, PCR has been recognized as the gold standard for respiratory virus testing. ![dna](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Cepheid-Icon-DNA-Molecule-Blue_1.png) **PCR Tests** PCR tests are more sensitive than antigen tests. PCR tests amplify genetic material from the virus; therefore, they can detect very small amounts of virus in a sample ![icon molecule](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Cepheid-Icon-Molecule_1.png) **Antigen Tests** Antigen tests detect viral proteins directly from a sample without amplification; therefore, false negatives may occur if there is a low or moderate amount of virus present ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Knowing%20More%20Matters%20Banner.png) ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Mobile%20Knowing%20More%20Banner%20.png) Time to result and intended use environment may vary, refer to individual test package insert for details. 1 Medline Plus: PCR Tests. Accessed 10/1/2022. <https://medlineplus.gov/lab-tests/pcr-tests/> 2 Cleveland Clinic: COVID-19 and PCR Testing. 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Readable Markdown
A PCR (polymerase chain reaction) test detects genetic material from an organism (i.e. bacteria or a virus) by copying a small portion of the genetic material in a process called amplification. Amplification allows for easier detection and identification of pathogens (disease-causing organisms) — sometimes even prior to symptoms surfacing — thus helping to prevent the transmission of infection and halt further disease spread. Tests that do not use amplification, such as antigen tests, might not achieve early detection because there are not enough viruses, bacteria, or other pathogens present in a patient’s sample. ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon1PCR.png) **1\. A patient gives a sample** A healthcare provider takes a sample of blood, saliva, mucus, or tissue. This sample contains DNA or RNA (genetic material). ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon2PCR.png) **2\. The sample is placed into a machine where PCR amplification occurs** A chemical reaction causes the sample to make billions of copies of the genetic sequence. ![](https://www.cepheid.com/content/dam/www-cepheid-com/images/-default-upload-bucket/icon3PCR.png) **3\. The test is complete** The machine determines if pathogens are present in the amplified sample. A healthcare professional examines the results to develop a treatment plan. What is the Difference Between PCR and Antigen Testing? Throughout the COVID-19 pandemic, both PCR and rapid antigen testing emerged as integral to slowing the spread of the virus. However, PCR has been recognized as the gold standard for respiratory virus testing. ![dna](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Cepheid-Icon-DNA-Molecule-Blue_1.png) **PCR Tests** PCR tests are more sensitive than antigen tests. PCR tests amplify genetic material from the virus; therefore, they can detect very small amounts of virus in a sample ![icon molecule](https://www.cepheid.com/content/dam/www-cepheid-com/images/knowing-more-matters/Cepheid-Icon-Molecule_1.png) **Antigen Tests** Antigen tests detect viral proteins directly from a sample without amplification; therefore, false negatives may occur if there is a low or moderate amount of virus present
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