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| Meta Title | About MIS | MIS | CDC |
| Meta Description | Multisystem inflammatory syndrome (MIS) can affect children (MIS-C) and adults (MIS-A). |
| Meta Canonical | null |
| Boilerpipe Text | Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different body parts become inflamed.
(MIS) can affect children (MIS-C) and adults (MIS-A).
What it is
Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different internal and external body parts become inflamed, including:
heart
lungs
kidneys
brain
skin
eyes
gastrointestinal tract
MIS can affect children (MIS-C) and adults (MIS-A). Although both are rare, MIS-C is more common than MIS-A. Most children with MIS-C appear to recover quickly from heart-related complications and have no lasting symptoms.
1
2
Risk factors
The main risk factor for developing MIS is being infected with SARS-CoV-2, the virus that causes COVID-19, within the previous 2-6 weeks.
Many children with MIS-C have had no or few symptoms of COVID-19.
Most children with MIS-C do not have any reported underlying medical conditions.
Most children with MIS-C are 5-11 years old, although it can occur in younger and older age groups.
Of the children with MIS-C who do report an underlying medical condition, obesity is the most common.
Prevention
Based on what we know now, the best way to prevent MIS-C or MIS-A is to take action to
protect yourself
from getting infected with SARS-CoV-2, including COVID-19, including getting an updated
COVID-19 vaccination
.
Quick facts
MIS-C has become much less common since the start of the pandemic. The number of reported MIS-C cases greatly decreased from 2020 through 2022 and have continued to decrease.
During the COVID-19 pandemic, peaks in MIS cases generally followed peaks in COVID-19 cases by about a month. Since then, rare cases continue to occur sporadically.
MIS-C cases tend to be higher among younger children aged 5-11 years compared with older adolescents, but cases have been reported across all age groups.
Most children recover from MIS-C without any long-term symptoms.
3
Poor heart function and enlarged arteries from MIS-C usually resolve quickly with treatment, generally within 6 months.
Some children with MIS-C, especially those who were severely ill in the intensive care unit, may have trouble with mental processing such as planning, focusing, and organizing.
Some children may have mental processing problems for several months after MIS-C but most recover by 2 years after illness.
What CDC is doing
Since May 2020, CDC has been tracking case reports of MIS-C. Data in this visualization are reported voluntarily to CDC by each jurisdiction's health department. CDC encourages all jurisdictions to report the most complete and accurate information that best represents the data available in their jurisdiction.
Sept. 8, 2025
Sources |
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# About MIS
Sept. 8, 2025
[Español](https://www.cdc.gov/mis/es/about/acerca-del-sindrome-inflamatorio-multisistemico.html)
## At a glance
- Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different body parts become inflamed.
- (MIS) can affect children (MIS-C) and adults (MIS-A).

## What it is
Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different internal and external body parts become inflamed, including:
- heart
- lungs
- kidneys
- brain
- skin
- eyes
- gastrointestinal tract
MIS can affect children (MIS-C) and adults (MIS-A). Although both are rare, MIS-C is more common than MIS-A. Most children with MIS-C appear to recover quickly from heart-related complications and have no lasting symptoms.[1](https://www.cdc.gov/mis/about/index.html#cdcreference_1)[2](https://www.cdc.gov/mis/about/index.html#cdcreference_2)
## Risk factors
- The main risk factor for developing MIS is being infected with SARS-CoV-2, the virus that causes COVID-19, within the previous 2-6 weeks.
- Many children with MIS-C have had no or few symptoms of COVID-19.
- Most children with MIS-C do not have any reported underlying medical conditions.
- Most children with MIS-C are 5-11 years old, although it can occur in younger and older age groups.
- Of the children with MIS-C who do report an underlying medical condition, obesity is the most common.
## Prevention
Based on what we know now, the best way to prevent MIS-C or MIS-A is to take action to [protect yourself](https://www.cdc.gov/respiratory-viruses/prevention/index.html) from getting infected with SARS-CoV-2, including COVID-19, including getting an updated [COVID-19 vaccination](https://www.cdc.gov/covid/vaccines/stay-up-to-date.html).
## Quick facts
- MIS-C has become much less common since the start of the pandemic. The number of reported MIS-C cases greatly decreased from 2020 through 2022 and have continued to decrease.
- During the COVID-19 pandemic, peaks in MIS cases generally followed peaks in COVID-19 cases by about a month. Since then, rare cases continue to occur sporadically.
- MIS-C cases tend to be higher among younger children aged 5-11 years compared with older adolescents, but cases have been reported across all age groups.
- Most children recover from MIS-C without any long-term symptoms.[3](https://www.cdc.gov/mis/about/index.html#cdcreference_3)
- Poor heart function and enlarged arteries from MIS-C usually resolve quickly with treatment, generally within 6 months.
- Some children with MIS-C, especially those who were severely ill in the intensive care unit, may have trouble with mental processing such as planning, focusing, and organizing.
- Some children may have mental processing problems for several months after MIS-C but most recover by 2 years after illness.
## What CDC is doing
Since May 2020, CDC has been tracking case reports of MIS-C. Data in this visualization are reported voluntarily to CDC by each jurisdiction's health department. CDC encourages all jurisdictions to report the most complete and accurate information that best represents the data available in their jurisdiction.
## On This Page
- [What it is](https://www.cdc.gov/mis/about/index.html#cdc_disease_basics_overview-what-it-is "What it is")
- [Risk factors](https://www.cdc.gov/mis/about/index.html#cdc_disease_basics_risk-risk-factors "Risk factors")
- [Prevention](https://www.cdc.gov/mis/about/index.html#cdc_disease_basics_prevention-prevention "Prevention")
- [Quick facts](https://www.cdc.gov/mis/about/index.html#cdc_disease_basics_quick_facts_callout_callout-quick-facts "Quick facts")
- [What CDC is doing](https://www.cdc.gov/mis/about/index.html#cdc_disease_basics_what_cdc_is_doing-what-cdc-is-doing "What CDC is doing")
Sept. 8, 2025
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References
1. [Neurological and Psychological Sequelae Associated With Multisystem Inflammatory Syndrome in Children \| Neurology \| JAMA Network Open \| JAMA Network](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2807432)
2. [Neurologic and Psychological Outcomes 2 Years After Multisystem Inflammatory Syndrome in Children \| Critical Care Medicine \| JAMA Network Open \| JAMA Network](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834756)
3. [Outcomes in the Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children Study - PubMed](https://pubmed.ncbi.nlm.nih.gov/39804656/)
Sources
- [Immunization and Respiratory Diseases (NCIRD) Home \| CDC](https://www.cdc.gov/ncird/index.html)
- [Neurologic and Psychological Outcomes 2 Years After Multisystem Inflammatory Syndrome in Children \| Critical Care Medicine \| JAMA Network Open \| JAMA Network](https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2834756)
- [Six-Month Outcomes in the Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children Study - PubMed](https://pubmed.ncbi.nlm.nih.gov/39804656/)
- [Six-month cardiac outcomes in children with multisystem inflammatory syndrome in children - PubMed](https://pubmed.ncbi.nlm.nih.gov/37114296/)[Six-Month Outcomes in the Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children Study - PubMed](https://pubmed.ncbi.nlm.nih.gov/39804656/)
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| Readable Markdown | - Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different body parts become inflamed.
- (MIS) can affect children (MIS-C) and adults (MIS-A).

## What it is
Multisystem inflammatory syndrome (MIS) is a rare but serious condition associated with SARS-CoV-2, the virus that causes COVID-19, in which different internal and external body parts become inflamed, including:
- heart
- lungs
- kidneys
- brain
- skin
- eyes
- gastrointestinal tract
MIS can affect children (MIS-C) and adults (MIS-A). Although both are rare, MIS-C is more common than MIS-A. Most children with MIS-C appear to recover quickly from heart-related complications and have no lasting symptoms.[1](https://www.cdc.gov/mis/about/index.html#cdcreference_1)[2](https://www.cdc.gov/mis/about/index.html#cdcreference_2)
## Risk factors
- The main risk factor for developing MIS is being infected with SARS-CoV-2, the virus that causes COVID-19, within the previous 2-6 weeks.
- Many children with MIS-C have had no or few symptoms of COVID-19.
- Most children with MIS-C do not have any reported underlying medical conditions.
- Most children with MIS-C are 5-11 years old, although it can occur in younger and older age groups.
- Of the children with MIS-C who do report an underlying medical condition, obesity is the most common.
## Prevention
Based on what we know now, the best way to prevent MIS-C or MIS-A is to take action to [protect yourself](https://www.cdc.gov/respiratory-viruses/prevention/index.html) from getting infected with SARS-CoV-2, including COVID-19, including getting an updated [COVID-19 vaccination](https://www.cdc.gov/covid/vaccines/stay-up-to-date.html).
## Quick facts
- MIS-C has become much less common since the start of the pandemic. The number of reported MIS-C cases greatly decreased from 2020 through 2022 and have continued to decrease.
- During the COVID-19 pandemic, peaks in MIS cases generally followed peaks in COVID-19 cases by about a month. Since then, rare cases continue to occur sporadically.
- MIS-C cases tend to be higher among younger children aged 5-11 years compared with older adolescents, but cases have been reported across all age groups.
- Most children recover from MIS-C without any long-term symptoms.[3](https://www.cdc.gov/mis/about/index.html#cdcreference_3)
- Poor heart function and enlarged arteries from MIS-C usually resolve quickly with treatment, generally within 6 months.
- Some children with MIS-C, especially those who were severely ill in the intensive care unit, may have trouble with mental processing such as planning, focusing, and organizing.
- Some children may have mental processing problems for several months after MIS-C but most recover by 2 years after illness.
## What CDC is doing
Since May 2020, CDC has been tracking case reports of MIS-C. Data in this visualization are reported voluntarily to CDC by each jurisdiction's health department. CDC encourages all jurisdictions to report the most complete and accurate information that best represents the data available in their jurisdiction.
Sept. 8, 2025
Sources |
| Shard | 5 (laksa) |
| Root Hash | 17308952984333333205 |
| Unparsed URL | gov,cdc!www,/mis/about/index.html s443 |