🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 47 (from laksa161)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa047.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://www.addictioncenter.com/antidepressants/\')), getAhrefsUnparsedNoserviceFromURL(\'https://www.addictioncenter.com/antidepressants/\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/www.addictioncenter.com\/antidepressants\/","crawl_time":1775923361,"first_indexed_time":1720338825,"http_code":200,"src_unparsed":"com,addictioncenter!www,\/antidepressants\/ s443","src_root_hash":"6417406535851876647","history_drop_reason":null,"meta_title":"Antidepressants","meta_descriptions":["Antidepressants change the brain’s makeup to treat mood disorders. As with any drug, side-effects and discontinuation symptoms can occur."],"attrs_boilerpipe_text":"What Are Antidepressants?\nAntidepressants are prescription medications used to treat moderate to severe\ndepression\nand other\nmental health conditions\n, including\nobsessive-compulsive disorder (OCD)\n,\npost-traumatic stress disorder (PTSD)\n, and\ngeneralized anxiety disorder\n.\nThe most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).\nCommon antidepressants include:\nFluoxetine (Prozac)\nEscitalopram (Lexapro)\nParoxetine (Paxil)\nSertraline (\nZoloft\n)\nDuloxetine (\nCymbalta\n)\nStudies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%).\nHow Do Antidepressants Work?\nAntidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention.\nBecause it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially.\nIt is essential to be patient and not quit taking your medication because you are not feeling the desired results right away.\nPaid Advertising. We receive advertising fees from purchases through BetterHelp links.\nOnline Counseling, Insurance Accepted.\nGet professional help from an online addiction and mental health counselor from BetterHelp.\nStart receiving support via phone, video, or live-chat.\nTypes Of Antidepressants\nSSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects.\nSSRIs include:\nFluoxetine (Prozac)\nSertraline (Zoloft)\nParoxetine (Paxil)\nFluvoxamine (Luvox)\nCitalopram (Celexa)\nEscitalopram (Lexapro)\nSNRIs\nSerotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain.\nSNRIs include:\nDesvenlafaxine (Pristiq, Khedezla)\nDuloxetine (Cymbalta, Irenka)\nLevomilnacipran (Fetzima)\nMilnacipran (Savella)\nVenlafaxine (Effexor XR)\nTCAs\nTricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an\noverdose\noccurs. They also cause more unpleasant side effects than SSRIs and SNRIs.\nHowever, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD,\nbipolar disorder\n, and nerve pain.\nTCA antidepressants include:\nAmitriptyline\nAmoxapine\nDesipramine (Norpramin)\nDoxepin\nImipramine (Tofranil)\nNortriptyline (Pamelor)\nProtriptyline\nTrimipramine\nWellbutrin\nWellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication.\nExplore These Featured Centers\nWhat Are The Side Effects Of Antidepressants?\nCommon side effects of SSRIs and SNRIs include:\nFeeling agitated, shaky, or anxious\nIndigestion and stomach aches\nDiarrhea or constipation\nLoss of appetite\nDizziness\nFatigue or difficulty sleeping\nHeadaches\nDecreased sex drive\nDifficulties achieving orgasm\nDifficulties obtaining or maintaining an erection\nCommon side effects of TCAs include:\nDry mouth\nBlurring of vision\nConstipation\nProblems urinating\nDrowsiness\nDizziness\nWeight gain\nHeart palpitations or fast heartbeat\nThese side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor.\nHow Are Antidepressants Taken?\nAntidepressants are usually taken in tablet form and often take 2-4 weeks to work.\nMost prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you.\nTypical Doses Of Antidepressants\nThere is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal.\nHowever, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor.\nCare That's Covered by Insurance\nAddiction Center is not affiliated with any insurance.\nWhat Is Antidepressant Discontinuation Syndrome?\nOften, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge.\nIf you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome.\nComing off antidepressant medication can cause\nantidepressant withdrawal\nand can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse.\nAbout 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse.\nDiscontinuation syndrome also includes physical symptoms such as:\nFlu-like symptoms\nInsomnia\nNausea\nDizziness\nAbnormal sensations such as tingling and shock-like feeling\nHyperarousal symptoms such as irritability, aggression, and reactivity\nDiscontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away.\nIn contrast, a\nrelapse\n:\nHappens a few weeks after stopping antidepressants\nLasts over one month\nResults in worsened depression symptoms\nHaving discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount.\nAlternative Options To Antidepressants\nAntidepressants, regardless of the class, do carry side effects, and each person reacts differently.\nSome people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication.\nIf you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression.\nOnline therapy\nprovides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as\nCBT\nand\nDBT\n, to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our\nonline therapy directory\ntoday.","attrs_markdown":"[Addiction Center](https:\/\/www.addictioncenter.com\/)\n\nSearch   Search By:   Rehab, Treatment, Location, Drug ...\n\nSearch\n\nMenu\n\n- [Find Treatment](https:\/\/www.addictioncenter.com\/rehabs\/)\n- [Online Therapy](https:\/\/www.addictioncenter.com\/online-therapy\/)\n- [Check Insurance Coverage](https:\/\/www.addictioncenter.com\/find-rehab-by-insurance-provider\/)\n- [Alcohol Assessment](https:\/\/www.addictioncenter.com\/alcohol\/assessment\/)\n\n- Addiction\n  - [Addiction](https:\/\/www.addictioncenter.com\/addiction\/)\n  - [Is Addiction A Disease?](https:\/\/www.addictioncenter.com\/addiction\/is-addiction-disease\/)\n  - [Substance Dependence](https:\/\/www.addictioncenter.com\/addiction\/dependence\/)\n  - [Addiction Vs. 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[Home](https:\/\/www.addictioncenter.com\/)\n2. Antidepressants\n# Antidepressants\nAntidepressants are the most commonly prescribed medication used to treat mental health disorders, particularly depression and anxiety.\n\n![Photo of Kristen Fuller, MD](https:\/\/www.addictioncenter.com\/app\/uploads\/2025\/08\/Dr.-Fuller-white-background-150x150.png)\n\nAuthor   [Kristen Fuller, MD](https:\/\/www.addictioncenter.com\/community\/author\/kristenfuller\/)\n\n## What Are Antidepressants?\nAntidepressants are prescription medications used to treat moderate to severe [depression](https:\/\/www.addictioncenter.com\/addiction\/depression-and-addiction\/) and other [mental health conditions](https:\/\/www.addictioncenter.com\/mental-health\/), including [obsessive-compulsive disorder (OCD)](https:\/\/www.addictioncenter.com\/addiction\/obsessive-compulsive-disorder\/), [post-traumatic stress disorder (PTSD)](https:\/\/www.addictioncenter.com\/addiction\/post-traumatic-stress-disorder\/), and [generalized anxiety disorder](https:\/\/www.addictioncenter.com\/addiction\/generalized-anxiety-disorder-addiction\/).\n\nThe most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).\n\nCommon antidepressants include:\n\n- Fluoxetine (Prozac)\n- Escitalopram (Lexapro)\n- Paroxetine (Paxil)\n- Sertraline ([Zoloft](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/zoloft-addiction-abuse\/))\n- Duloxetine ([Cymbalta](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/cymbalta-addiction-abuse\/))\n\nStudies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%).\n\nFind a Treatment Center Near You\n\nDiscover affordable rehab centers near you, offering easy access and convenience. Stay close to family and friends while getting the support you need.\n\n- Detox\n- Inpatient Rehab\n- Outpatient Rehab\n\n***\nOr\n\nAd\n\nStart Your Recovery Now\n\nExplore your options with Guardian Recovery.\n\n[![](https:\/\/www.addictioncenter.com\/app\/uploads\/2026\/03\/gr-logo-full.svg)](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\n[(855) 502-4871](tel:8555024871)\n\n[Learn More](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\nStart Your Recovery Now\n\n![](https:\/\/www.addictioncenter.com\/app\/uploads\/2025\/12\/rr-logo-full.svg)\n\n[(870) 515-8609](tel:8705158609)\n\n[Learn More](https:\/\/www.addictioncenter.com\/about\/refine-recovery\/)\n## How Do Antidepressants Work?\nAntidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention.\n\nBecause it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially.\n\nIt is essential to be patient and not quit taking your medication because you are not feeling the desired results right away.\n\nPaid Advertising. We receive advertising fees from purchases through BetterHelp links.\n\nOnline Counseling, Insurance Accepted.\n\nGet professional help from an online addiction and mental health counselor from BetterHelp.\n\nStart receiving support via phone, video, or live-chat.\n\n[Take the Quiz.](https:\/\/impact.betterhelp.com\/c\/3816442\/3769750\/39552)\n\nGet Matched\n\nBegin Therapy\n\n- Tailored Matching\n- Easy Online Scheduling\n- 30,000+ Licensed Therapists\n\n[TAKE ASSESSMENT START THE QUIZ](https:\/\/impact.betterhelp.com\/c\/3816442\/3769750\/39552)\n\n- Tailored Matching\n- Easy Online Scheduling\n- 30,000+ Licensed Therapists\n## Types Of Antidepressants\n### SSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects.\n\nSSRIs include:\n\n- Fluoxetine (Prozac)\n- Sertraline (Zoloft)\n- Paroxetine (Paxil)\n\n- Fluvoxamine (Luvox)\n- Citalopram (Celexa)\n- Escitalopram (Lexapro)\n### SNRIs\nSerotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain.\n\nSNRIs include:\n\n- Desvenlafaxine (Pristiq, Khedezla)\n- Duloxetine (Cymbalta, Irenka)\n- Levomilnacipran (Fetzima)\n- Milnacipran (Savella)\n- Venlafaxine (Effexor XR)\n### TCAs\nTricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an [overdose](https:\/\/www.addictioncenter.com\/drugs\/overdose\/) occurs. They also cause more unpleasant side effects than SSRIs and SNRIs.\n\nHowever, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD, [bipolar disorder](https:\/\/www.addictioncenter.com\/addiction\/bipolar-disorder\/), and nerve pain.\n\nTCA antidepressants include:\n\n- Amitriptyline\n- Amoxapine\n- Desipramine (Norpramin)\n- Doxepin\n\n- Imipramine (Tofranil)\n- Nortriptyline (Pamelor)\n- Protriptyline\n- Trimipramine\n### Wellbutrin\nWellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication.\n\nExplore These Featured Centers\n\n[Browse Treatment Centers](https:\/\/www.addictioncenter.com\/rehabs\/)\n\n## What Are The Side Effects Of Antidepressants?\nCommon side effects of SSRIs and SNRIs include:\n\n- Feeling agitated, shaky, or anxious\n- Indigestion and stomach aches\n- Diarrhea or constipation\n- Loss of appetite\n- Dizziness\n\n- Fatigue or difficulty sleeping\n- Headaches\n- Decreased sex drive\n- Difficulties achieving orgasm\n- Difficulties obtaining or maintaining an erection\n\nCommon side effects of TCAs include:\n\n- Dry mouth\n- Blurring of vision\n- Constipation\n- Problems urinating\n\n- Drowsiness\n- Dizziness\n- Weight gain\n- Heart palpitations or fast heartbeat\n\nThese side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor.\n\n## How Are Antidepressants Taken?\nAntidepressants are usually taken in tablet form and often take 2-4 weeks to work.\n\nMost prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you.\n\n## Typical Doses Of Antidepressants\nThere is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal.\n\nHowever, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor.\n\nCare That's Covered by Insurance\n\nExplore rehabs that accept your insurance today! Start your recovery journey with peace of mind, knowing your care is covered.\n\n[Find Rehab by Insurance Provider](https:\/\/www.addictioncenter.com\/find-rehab-by-insurance-provider\/)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/aetna_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=aetna-insurance-for-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2022\/11\/cigna_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=cigna-insurance-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2022\/11\/bluecrossblueshield_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=bluecross-blueshield-insurance-for-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/unitedhealthcare_logo.svg)](http:\/\/addictioncenter.com\/rehabs\/results\/?payments=united-healthcare-insurance-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/tricare_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=tricare-insurance)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/humana_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=humana-health-insurance-addiction-treatment)\n\nAddiction Center is not affiliated with any insurance.\n## What Is Antidepressant Discontinuation Syndrome?\nOften, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge.\n\nIf you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome.\n\nComing off antidepressant medication can cause [antidepressant withdrawal](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/withdrawal-detox\/) and can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse.\n\nAbout 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse.\n\nDiscontinuation syndrome also includes physical symptoms such as:\n\n- Flu-like symptoms\n- [Insomnia](https:\/\/www.addictioncenter.com\/addiction\/dual-diagnosis\/insomnia\/)\n- Nausea\n- Dizziness\n- Abnormal sensations such as tingling and shock-like feeling\n- Hyperarousal symptoms such as irritability, aggression, and reactivity\n\nDiscontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away.\n\nIn contrast, a [relapse](https:\/\/www.addictioncenter.com\/treatment\/chronic-relapse\/):\n\n- Happens a few weeks after stopping antidepressants\n- Lasts over one month\n- Results in worsened depression symptoms\n\nHaving discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount.\n\n## Alternative Options To Antidepressants\nAntidepressants, regardless of the class, do carry side effects, and each person reacts differently.\n\nSome people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication.\n\nIf you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression.\n\n[Online therapy](https:\/\/www.addictioncenter.com\/online-therapy\/) provides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as [CBT](https:\/\/www.addictioncenter.com\/treatment\/cognitive-behavioral-therapy\/) and [DBT](https:\/\/www.addictioncenter.com\/treatment\/dialectical-behavior-therapy\/), to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our [online therapy directory](https:\/\/www.addictioncenter.com\/online-therapy\/) today.\n\nLast Updated: December 15, 2025\n\nSources\n\n1. Centers For Disease Control and Prevention (2020). Antidepressant Use Among Adults: United States, 2015-2018. Retrieved on March 6, 2024, from  <https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db377.htm>\n2. Chu A, Wadhwa R. (2023). Selective Serotonin Reuptake Inhibitors. In: StatPearls \\[Internet\\]: StatPearls Publishing. Retrieved on March 6, 2024, from  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554406\/>\n3. Ferguson JM. (2001). SSRI Antidepressant Medications: Adverse Effects and Tolerability. The Primary Care Companion To The Journal Of Clinical Psychiatry, 3(1), 22-27. Retrieved on March 6, 2024, from  <https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC181155\/>\n4. Gabrial M, Sharma V. (2017). Antidepressant discontinuation syndrome. Canadian Medical Association Journal, 189(21), E747. Retrieved on March 6, 2024, from   [https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449237\/\\#:~:text=The%20mnemonic%20FINISH%20summarizes%20the,disturbances%20](https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5449237\/#:~:text=The%20mnemonic%20FINISH%20summarizes%20the,disturbances%20)\n5. Hieronymus F. (2019). Which antidepressant doses are optional? Retrieved on March 6, 2024, from  <https:\/\/www.thelancet.com\/journals\/lanpsy\/article\/PIIS2215-0366(19)30221-4\/fulltext>\n6. Moraczewski J, Awosika AO, Aedma KK. (2023). Tricyclic Antidepressants. In: StatPearls \\[Internet\\]: StatPearls Publishing. Retrieved on March 7, 2024, from  <https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557791\/>\n\nRelated Articles\n\n- [Signs Of Antidepressant Abuse](https:\/\/www.addictioncenter.com\/antidepressants\/symptoms-signs\/)\n- [Antidepressant Withdrawal And Detox](https:\/\/www.addictioncenter.com\/antidepressants\/withdrawal-detox\/)\n- [Antidepressant Treatment And Rehab](https:\/\/www.addictioncenter.com\/antidepressants\/treatment\/)\n\nFurther Reading\n\n- [Inpatient Drug And Alcohol Rehab](https:\/\/www.addictioncenter.com\/treatment\/inpatient-rehab\/)\n- [Drug And Alcohol Detox](https:\/\/www.addictioncenter.com\/treatment\/drug-and-alcohol-detox\/)\n- [How Do I Pay For Addiction Treatment?](https:\/\/www.addictioncenter.com\/rehab-questions\/paying-for-treatment\/)\n\n- Related Topics\n\n- [Signs Of Antidepressant Abuse](https:\/\/www.addictioncenter.com\/antidepressants\/symptoms-signs\/)\n- [Antidepressant Withdrawal And Detox](https:\/\/www.addictioncenter.com\/antidepressants\/withdrawal-detox\/)\n- [Tianeptine Addiction And Abuse](https:\/\/www.addictioncenter.com\/antidepressants\/tianeptine\/)\n- [Antidepressant Treatment And Rehab](https:\/\/www.addictioncenter.com\/antidepressants\/treatment\/)\n- [Cymbalta](https:\/\/www.addictioncenter.com\/antidepressants\/cymbalta\/)\n- [Flexeril](https:\/\/www.addictioncenter.com\/antidepressants\/flexeril\/)\n- [Elavil](https:\/\/www.addictioncenter.com\/antidepressants\/elavil\/)\n- [Remeron Addiction And Abuse](https:\/\/www.addictioncenter.com\/antidepressants\/remeron\/)\n- [Zoloft](https:\/\/www.addictioncenter.com\/antidepressants\/zoloft\/)\n- [Trazodone](https:\/\/www.addictioncenter.com\/antidepressants\/trazodone\/)\n\nAd\n\nAd\n\n[![](https:\/\/www.addictioncenter.com\/app\/uploads\/2026\/03\/gr-logo-full.svg)](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\nStart the road to recovery\n\n- Free and confidential\n- Available 24\/7\n- Discover your treatment options\n\n[(855) 502-4871](tel:8555024871)\n\n[Learn More](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\nAd\n\n![](https:\/\/www.addictioncenter.com\/app\/uploads\/2025\/12\/rr-logo-full.svg)\n\nStart the road to recovery\n\n- Free and confidential\n- Available 24\/7\n- Discover your treatment options\n\n[(870) 515-8609](tel:8705158609)\n\n[Learn More](https:\/\/www.addictioncenter.com\/about\/refine-recovery\/)\n\nFind a Treatment Center\n\n\\[Or\\]\n\n[View All Rehab Options](https:\/\/www.addictioncenter.com\/rehabs\/)\n\n- [Rehabs](https:\/\/www.addictioncenter.com\/rehabs\/)\n- [Browse By Location](https:\/\/www.addictioncenter.com\/find-rehab-by-location\/)\n- [Check Insurance Coverage](https:\/\/www.addictioncenter.com\/find-rehab-by-insurance-provider\/)\n- [Online Therapy](https:\/\/www.addictioncenter.com\/online-therapy\/)\n- [Alcohol Assessment](https:\/\/www.addictioncenter.com\/alcohol\/assessment\/)\n\n- [Treatment Options](https:\/\/www.addictioncenter.com\/treatment\/)\n- - 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The treatment centers found on the Addiction Center site are paid advertisers. Addiction Center does not endorse any treatment facility advertising on our site and does not guarantee the quality of care provided, or the results to be achieved, by any treatment facility. The information provided by Addiction Center is not a substitute for professional treatment advice.\n\nCopyright © 2026 Addiction Center  \nAddiction Center is owned and operated by [Recovery Worldwide, LLC](https:\/\/www.recoveryworldwide.com\/)\n\nAd\n\nCall   ![](https:\/\/www.addictioncenter.com\/app\/uploads\/2026\/03\/gr-logo-full.svg)\n\n[(855) 502-4871](tel:8555024871)\n\n[Learn More](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\n[(870) 515-8609](tel:8705158609)\n\nCall      now or    [learn more](https:\/\/www.addictioncenter.com\/about\/refine-recovery\/)\n\nRehab Options\n\n[Find Rehab Near You](https:\/\/www.addictioncenter.com\/rehabs\/results\/)\n\n[Travel For Rehab](https:\/\/www.addictioncenter.com\/rehabs\/results\/?location=travel)\n\nFeatured Center\n\nAd\n\n[![](https:\/\/www.addictioncenter.com\/app\/uploads\/2026\/03\/gr-logo-full.svg)](https:\/\/www.addictioncenter.com\/about\/guardian-recovery\/)\n\nExplore Guardian Recovery’s network of 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[![Aetna](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/aetna.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=aetna-insurance-for-addiction-treatment)\n- [![Blue Cross Blue Shield](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/bluecross_blueshield.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=bluecross-blueshield-insurance-for-addiction-treatment)\n- [![Cigna](https:\/\/www.addictioncenter.com\/app\/uploads\/2016\/01\/cigna-logo-e1484232014596.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=cigna-insurance-addiction-treatment)\n- [![Humana](https:\/\/www.addictioncenter.com\/app\/uploads\/2018\/04\/humana-logo.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=humana-health-insurance-addiction-treatment)\n- [![Magellan Health](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/06\/Magellan.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=magellan-health-addiction-treatment)\n- [![Beacon](https:\/\/www.addictioncenter.com\/app\/uploads\/2018\/04\/beacon-logo.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=beacon-health-options-insurance-for-addiction-treatment)\n- [![Anthem](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/Anthem.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=anthem)\n- [![Health Net](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/Health-Net-Logo.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=healthnet)\n- [![Optum](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/Optum-Logo.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=optum)\n- [![ComPsych](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/07\/partner-logo-compsych.png)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=compsych)\n- [![TRICARE](https:\/\/www.addictioncenter.com\/app\/uploads\/2020\/06\/TRICARE.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=tricare-insurance)\n\nSubstances\n\n- [Alcohol](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=alcohol)\n- [Opioids](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=opiates)\n- [Benzodiazepines](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=benzodiazepines)\n- [Cocaine](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=cocaine)\n- [Methamphetamine](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=methamphetamine)\n- [Prescription Drugs](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=prescription-drugs)\n- [Marijuana](https:\/\/www.addictioncenter.com\/rehabs\/results\/?substances=marijuana)\n\nRehab FAQs\n\n- [How Much Does Rehab Cost?](https:\/\/www.addictioncenter.com\/rehab-questions\/cost-of-drug-and-alcohol-treatment\/)\n- [How Do I Pay For Rehab?](https:\/\/www.addictioncenter.com\/rehab-questions\/paying-for-treatment\/)\n- [Will I Lose My Job If I Go To Rehab?](https:\/\/www.addictioncenter.com\/rehab-questions\/can-i-get-my-job-back\/)\n- [What Is A Typical Day In Rehab Like?](https:\/\/www.addictioncenter.com\/rehab-questions\/typical-day-rehab\/)\n- [How Do I Prepare For Rehab?](https:\/\/www.addictioncenter.com\/rehab-questions\/how-do-i-prepare-for-rehab\/)\n- [How To Stage An Intervention](https:\/\/www.addictioncenter.com\/treatment\/stage-intervention\/step-by-step-guide\/)\n\nAd","attrs_readable_markdown":"## What Are Antidepressants?\nAntidepressants are prescription medications used to treat moderate to severe [depression](https:\/\/www.addictioncenter.com\/addiction\/depression-and-addiction\/) and other [mental health conditions](https:\/\/www.addictioncenter.com\/mental-health\/), including [obsessive-compulsive disorder (OCD)](https:\/\/www.addictioncenter.com\/addiction\/obsessive-compulsive-disorder\/), [post-traumatic stress disorder (PTSD)](https:\/\/www.addictioncenter.com\/addiction\/post-traumatic-stress-disorder\/), and [generalized anxiety disorder](https:\/\/www.addictioncenter.com\/addiction\/generalized-anxiety-disorder-addiction\/).\n\nThe most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).\n\nCommon antidepressants include:\n\n- Fluoxetine (Prozac)\n- Escitalopram (Lexapro)\n- Paroxetine (Paxil)\n- Sertraline ([Zoloft](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/zoloft-addiction-abuse\/))\n- Duloxetine ([Cymbalta](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/cymbalta-addiction-abuse\/))\n\nStudies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%).\n\n## How Do Antidepressants Work?\nAntidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention.\n\nBecause it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially.\n\nIt is essential to be patient and not quit taking your medication because you are not feeling the desired results right away.\n\nPaid Advertising. We receive advertising fees from purchases through BetterHelp links.\n\nOnline Counseling, Insurance Accepted.\n\nGet professional help from an online addiction and mental health counselor from BetterHelp.\n\nStart receiving support via phone, video, or live-chat.\n## Types Of Antidepressants\n### SSRIs\nSelective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects.\n\nSSRIs include:\n\n- Fluoxetine (Prozac)\n- Sertraline (Zoloft)\n- Paroxetine (Paxil)\n\n- Fluvoxamine (Luvox)\n- Citalopram (Celexa)\n- Escitalopram (Lexapro)\n### SNRIs\nSerotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain.\n\nSNRIs include:\n\n- Desvenlafaxine (Pristiq, Khedezla)\n- Duloxetine (Cymbalta, Irenka)\n- Levomilnacipran (Fetzima)\n- Milnacipran (Savella)\n- Venlafaxine (Effexor XR)\n### TCAs\nTricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an [overdose](https:\/\/www.addictioncenter.com\/drugs\/overdose\/) occurs. They also cause more unpleasant side effects than SSRIs and SNRIs.\n\nHowever, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD, [bipolar disorder](https:\/\/www.addictioncenter.com\/addiction\/bipolar-disorder\/), and nerve pain.\n\nTCA antidepressants include:\n\n- Amitriptyline\n- Amoxapine\n- Desipramine (Norpramin)\n- Doxepin\n\n- Imipramine (Tofranil)\n- Nortriptyline (Pamelor)\n- Protriptyline\n- Trimipramine\n### Wellbutrin\nWellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication.\n\nExplore These Featured Centers\n\n## What Are The Side Effects Of Antidepressants?\nCommon side effects of SSRIs and SNRIs include:\n\n- Feeling agitated, shaky, or anxious\n- Indigestion and stomach aches\n- Diarrhea or constipation\n- Loss of appetite\n- Dizziness\n\n- Fatigue or difficulty sleeping\n- Headaches\n- Decreased sex drive\n- Difficulties achieving orgasm\n- Difficulties obtaining or maintaining an erection\n\nCommon side effects of TCAs include:\n\n- Dry mouth\n- Blurring of vision\n- Constipation\n- Problems urinating\n\n- Drowsiness\n- Dizziness\n- Weight gain\n- Heart palpitations or fast heartbeat\n\nThese side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor.\n\n## How Are Antidepressants Taken?\nAntidepressants are usually taken in tablet form and often take 2-4 weeks to work.\n\nMost prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you.\n\n## Typical Doses Of Antidepressants\nThere is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal.\n\nHowever, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor.\n\nCare That's Covered by Insurance\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/aetna_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=aetna-insurance-for-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2022\/11\/cigna_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=cigna-insurance-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2022\/11\/bluecrossblueshield_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=bluecross-blueshield-insurance-for-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/unitedhealthcare_logo.svg)](http:\/\/addictioncenter.com\/rehabs\/results\/?payments=united-healthcare-insurance-addiction-treatment)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/tricare_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=tricare-insurance)\n\n[![Insurance Logo](https:\/\/www.addictioncenter.com\/app\/uploads\/2021\/03\/humana_logo.svg)](https:\/\/www.addictioncenter.com\/rehabs\/results\/?payments=humana-health-insurance-addiction-treatment)\n\nAddiction Center is not affiliated with any insurance.\n## What Is Antidepressant Discontinuation Syndrome?\nOften, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge.\n\nIf you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome.\n\nComing off antidepressant medication can cause [antidepressant withdrawal](https:\/\/www.addictioncenter.com\/stimulants\/antidepressants\/withdrawal-detox\/) and can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse.\n\nAbout 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse.\n\nDiscontinuation syndrome also includes physical symptoms such as:\n\n- Flu-like symptoms\n- [Insomnia](https:\/\/www.addictioncenter.com\/addiction\/dual-diagnosis\/insomnia\/)\n- Nausea\n- Dizziness\n- Abnormal sensations such as tingling and shock-like feeling\n- Hyperarousal symptoms such as irritability, aggression, and reactivity\n\nDiscontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away.\n\nIn contrast, a [relapse](https:\/\/www.addictioncenter.com\/treatment\/chronic-relapse\/):\n\n- Happens a few weeks after stopping antidepressants\n- Lasts over one month\n- Results in worsened depression symptoms\n\nHaving discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount.\n\n## Alternative Options To Antidepressants\nAntidepressants, regardless of the class, do carry side effects, and each person reacts differently.\n\nSome people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication.\n\nIf you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression.\n\n[Online therapy](https:\/\/www.addictioncenter.com\/online-therapy\/) provides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as [CBT](https:\/\/www.addictioncenter.com\/treatment\/cognitive-behavioral-therapy\/) and [DBT](https:\/\/www.addictioncenter.com\/treatment\/dialectical-behavior-therapy\/), to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our [online therapy directory](https:\/\/www.addictioncenter.com\/online-therapy\/) today.","meta_canonical":null}

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Meta Description	Antidepressants change the brain’s makeup to treat mood disorders. As with any drug, side-effects and discontinuation symptoms can occur.
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Boilerpipe Text	What Are Antidepressants? Antidepressants are prescription medications used to treat moderate to severe depression and other mental health conditions , including obsessive-compulsive disorder (OCD) , post-traumatic stress disorder (PTSD) , and generalized anxiety disorder . The most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Common antidepressants include: Fluoxetine (Prozac) Escitalopram (Lexapro) Paroxetine (Paxil) Sertraline ( Zoloft ) Duloxetine ( Cymbalta ) Studies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%). How Do Antidepressants Work? Antidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention. Because it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially. It is essential to be patient and not quit taking your medication because you are not feeling the desired results right away. Paid Advertising. We receive advertising fees from purchases through BetterHelp links. Online Counseling, Insurance Accepted. Get professional help from an online addiction and mental health counselor from BetterHelp. Start receiving support via phone, video, or live-chat. Types Of Antidepressants SSRIs Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects. SSRIs include: Fluoxetine (Prozac) Sertraline (Zoloft) Paroxetine (Paxil) Fluvoxamine (Luvox) Citalopram (Celexa) Escitalopram (Lexapro) SNRIs Serotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain. SNRIs include: Desvenlafaxine (Pristiq, Khedezla) Duloxetine (Cymbalta, Irenka) Levomilnacipran (Fetzima) Milnacipran (Savella) Venlafaxine (Effexor XR) TCAs Tricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an overdose occurs. They also cause more unpleasant side effects than SSRIs and SNRIs. However, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD, bipolar disorder , and nerve pain. TCA antidepressants include: Amitriptyline Amoxapine Desipramine (Norpramin) Doxepin Imipramine (Tofranil) Nortriptyline (Pamelor) Protriptyline Trimipramine Wellbutrin Wellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication. Explore These Featured Centers What Are The Side Effects Of Antidepressants? Common side effects of SSRIs and SNRIs include: Feeling agitated, shaky, or anxious Indigestion and stomach aches Diarrhea or constipation Loss of appetite Dizziness Fatigue or difficulty sleeping Headaches Decreased sex drive Difficulties achieving orgasm Difficulties obtaining or maintaining an erection Common side effects of TCAs include: Dry mouth Blurring of vision Constipation Problems urinating Drowsiness Dizziness Weight gain Heart palpitations or fast heartbeat These side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor. How Are Antidepressants Taken? Antidepressants are usually taken in tablet form and often take 2-4 weeks to work. Most prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you. Typical Doses Of Antidepressants There is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal. However, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor. Care That's Covered by Insurance Addiction Center is not affiliated with any insurance. What Is Antidepressant Discontinuation Syndrome? Often, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge. If you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome. Coming off antidepressant medication can cause antidepressant withdrawal and can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse. About 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse. Discontinuation syndrome also includes physical symptoms such as: Flu-like symptoms Insomnia Nausea Dizziness Abnormal sensations such as tingling and shock-like feeling Hyperarousal symptoms such as irritability, aggression, and reactivity Discontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away. In contrast, a relapse : Happens a few weeks after stopping antidepressants Lasts over one month Results in worsened depression symptoms Having discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount. Alternative Options To Antidepressants Antidepressants, regardless of the class, do carry side effects, and each person reacts differently. Some people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication. If you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression. Online therapy provides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as CBT and DBT , to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our online therapy directory today.
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[Home](https://www.addictioncenter.com/) 2. Antidepressants # Antidepressants Antidepressants are the most commonly prescribed medication used to treat mental health disorders, particularly depression and anxiety. ![Photo of Kristen Fuller, MD](https://www.addictioncenter.com/app/uploads/2025/08/Dr.-Fuller-white-background-150x150.png) Author [Kristen Fuller, MD](https://www.addictioncenter.com/community/author/kristenfuller/) ## What Are Antidepressants? Antidepressants are prescription medications used to treat moderate to severe [depression](https://www.addictioncenter.com/addiction/depression-and-addiction/) and other [mental health conditions](https://www.addictioncenter.com/mental-health/), including [obsessive-compulsive disorder (OCD)](https://www.addictioncenter.com/addiction/obsessive-compulsive-disorder/), [post-traumatic stress disorder (PTSD)](https://www.addictioncenter.com/addiction/post-traumatic-stress-disorder/), and [generalized anxiety disorder](https://www.addictioncenter.com/addiction/generalized-anxiety-disorder-addiction/). The most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Common antidepressants include: - Fluoxetine (Prozac) - Escitalopram (Lexapro) - Paroxetine (Paxil) - Sertraline ([Zoloft](https://www.addictioncenter.com/stimulants/antidepressants/zoloft-addiction-abuse/)) - Duloxetine ([Cymbalta](https://www.addictioncenter.com/stimulants/antidepressants/cymbalta-addiction-abuse/)) Studies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%). Find a Treatment Center Near You Discover affordable rehab centers near you, offering easy access and convenience. Stay close to family and friends while getting the support you need. - Detox - Inpatient Rehab - Outpatient Rehab *** Or Ad Start Your Recovery Now Explore your options with Guardian Recovery. [![](https://www.addictioncenter.com/app/uploads/2026/03/gr-logo-full.svg)](https://www.addictioncenter.com/about/guardian-recovery/) [(855) 502-4871](tel:8555024871) [Learn More](https://www.addictioncenter.com/about/guardian-recovery/) Start Your Recovery Now ![](https://www.addictioncenter.com/app/uploads/2025/12/rr-logo-full.svg) [(870) 515-8609](tel:8705158609) [Learn More](https://www.addictioncenter.com/about/refine-recovery/) ## How Do Antidepressants Work? Antidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention. Because it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially. It is essential to be patient and not quit taking your medication because you are not feeling the desired results right away. Paid Advertising. We receive advertising fees from purchases through BetterHelp links. Online Counseling, Insurance Accepted. Get professional help from an online addiction and mental health counselor from BetterHelp. Start receiving support via phone, video, or live-chat. [Take the Quiz.](https://impact.betterhelp.com/c/3816442/3769750/39552) Get Matched Begin Therapy - Tailored Matching - Easy Online Scheduling - 30,000+ Licensed Therapists [TAKE ASSESSMENT START THE QUIZ](https://impact.betterhelp.com/c/3816442/3769750/39552) - Tailored Matching - Easy Online Scheduling - 30,000+ Licensed Therapists ## Types Of Antidepressants ### SSRIs Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects. SSRIs include: - Fluoxetine (Prozac) - Sertraline (Zoloft) - Paroxetine (Paxil) - Fluvoxamine (Luvox) - Citalopram (Celexa) - Escitalopram (Lexapro) ### SNRIs Serotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain. SNRIs include: - Desvenlafaxine (Pristiq, Khedezla) - Duloxetine (Cymbalta, Irenka) - Levomilnacipran (Fetzima) - Milnacipran (Savella) - Venlafaxine (Effexor XR) ### TCAs Tricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an [overdose](https://www.addictioncenter.com/drugs/overdose/) occurs. They also cause more unpleasant side effects than SSRIs and SNRIs. However, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD, [bipolar disorder](https://www.addictioncenter.com/addiction/bipolar-disorder/), and nerve pain. TCA antidepressants include: - Amitriptyline - Amoxapine - Desipramine (Norpramin) - Doxepin - Imipramine (Tofranil) - Nortriptyline (Pamelor) - Protriptyline - Trimipramine ### Wellbutrin Wellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication. Explore These Featured Centers [Browse Treatment Centers](https://www.addictioncenter.com/rehabs/) ## What Are The Side Effects Of Antidepressants? Common side effects of SSRIs and SNRIs include: - Feeling agitated, shaky, or anxious - Indigestion and stomach aches - Diarrhea or constipation - Loss of appetite - Dizziness - Fatigue or difficulty sleeping - Headaches - Decreased sex drive - Difficulties achieving orgasm - Difficulties obtaining or maintaining an erection Common side effects of TCAs include: - Dry mouth - Blurring of vision - Constipation - Problems urinating - Drowsiness - Dizziness - Weight gain - Heart palpitations or fast heartbeat These side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor. ## How Are Antidepressants Taken? Antidepressants are usually taken in tablet form and often take 2-4 weeks to work. Most prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you. ## Typical Doses Of Antidepressants There is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal. However, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor. Care That's Covered by Insurance Explore rehabs that accept your insurance today! Start your recovery journey with peace of mind, knowing your care is covered. [Find Rehab by Insurance Provider](https://www.addictioncenter.com/find-rehab-by-insurance-provider/) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/aetna_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=aetna-insurance-for-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2022/11/cigna_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=cigna-insurance-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2022/11/bluecrossblueshield_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=bluecross-blueshield-insurance-for-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/unitedhealthcare_logo.svg)](http://addictioncenter.com/rehabs/results/?payments=united-healthcare-insurance-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/tricare_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=tricare-insurance) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/humana_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=humana-health-insurance-addiction-treatment) Addiction Center is not affiliated with any insurance. ## What Is Antidepressant Discontinuation Syndrome? Often, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge. If you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome. Coming off antidepressant medication can cause [antidepressant withdrawal](https://www.addictioncenter.com/stimulants/antidepressants/withdrawal-detox/) and can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse. About 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse. Discontinuation syndrome also includes physical symptoms such as: - Flu-like symptoms - [Insomnia](https://www.addictioncenter.com/addiction/dual-diagnosis/insomnia/) - Nausea - Dizziness - Abnormal sensations such as tingling and shock-like feeling - Hyperarousal symptoms such as irritability, aggression, and reactivity Discontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away. In contrast, a [relapse](https://www.addictioncenter.com/treatment/chronic-relapse/): - Happens a few weeks after stopping antidepressants - Lasts over one month - Results in worsened depression symptoms Having discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount. ## Alternative Options To Antidepressants Antidepressants, regardless of the class, do carry side effects, and each person reacts differently. Some people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication. If you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression. [Online therapy](https://www.addictioncenter.com/online-therapy/) provides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as [CBT](https://www.addictioncenter.com/treatment/cognitive-behavioral-therapy/) and [DBT](https://www.addictioncenter.com/treatment/dialectical-behavior-therapy/), to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our [online therapy directory](https://www.addictioncenter.com/online-therapy/) today. Last Updated: December 15, 2025 Sources 1. Centers For Disease Control and Prevention (2020). Antidepressant Use Among Adults: United States, 2015-2018. Retrieved on March 6, 2024, from <https://www.cdc.gov/nchs/products/databriefs/db377.htm> 2. Chu A, Wadhwa R. (2023). Selective Serotonin Reuptake Inhibitors. In: StatPearls \[Internet\]: StatPearls Publishing. Retrieved on March 6, 2024, from <https://www.ncbi.nlm.nih.gov/books/NBK554406/> 3. Ferguson JM. (2001). SSRI Antidepressant Medications: Adverse Effects and Tolerability. The Primary Care Companion To The Journal Of Clinical Psychiatry, 3(1), 22-27. Retrieved on March 6, 2024, from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181155/> 4. Gabrial M, Sharma V. (2017). Antidepressant discontinuation syndrome. Canadian Medical Association Journal, 189(21), E747. Retrieved on March 6, 2024, from [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449237/\#:~:text=The%20mnemonic%20FINISH%20summarizes%20the,disturbances%20](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449237/#:~:text=The%20mnemonic%20FINISH%20summarizes%20the,disturbances%20) 5. Hieronymus F. (2019). Which antidepressant doses are optional? Retrieved on March 6, 2024, from <https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30221-4/fulltext> 6. Moraczewski J, Awosika AO, Aedma KK. (2023). Tricyclic Antidepressants. In: StatPearls \[Internet\]: StatPearls Publishing. Retrieved on March 7, 2024, from <https://www.ncbi.nlm.nih.gov/books/NBK557791/> Related Articles - [Signs Of Antidepressant Abuse](https://www.addictioncenter.com/antidepressants/symptoms-signs/) - [Antidepressant Withdrawal And Detox](https://www.addictioncenter.com/antidepressants/withdrawal-detox/) - [Antidepressant Treatment And Rehab](https://www.addictioncenter.com/antidepressants/treatment/) Further Reading - [Inpatient Drug And Alcohol Rehab](https://www.addictioncenter.com/treatment/inpatient-rehab/) - [Drug And Alcohol Detox](https://www.addictioncenter.com/treatment/drug-and-alcohol-detox/) - [How Do I Pay For Addiction Treatment?](https://www.addictioncenter.com/rehab-questions/paying-for-treatment/) - Related Topics - [Signs Of Antidepressant Abuse](https://www.addictioncenter.com/antidepressants/symptoms-signs/) - [Antidepressant Withdrawal And Detox](https://www.addictioncenter.com/antidepressants/withdrawal-detox/) - [Tianeptine Addiction And Abuse](https://www.addictioncenter.com/antidepressants/tianeptine/) - 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Readable Markdown	## What Are Antidepressants? Antidepressants are prescription medications used to treat moderate to severe [depression](https://www.addictioncenter.com/addiction/depression-and-addiction/) and other [mental health conditions](https://www.addictioncenter.com/mental-health/), including [obsessive-compulsive disorder (OCD)](https://www.addictioncenter.com/addiction/obsessive-compulsive-disorder/), [post-traumatic stress disorder (PTSD)](https://www.addictioncenter.com/addiction/post-traumatic-stress-disorder/), and [generalized anxiety disorder](https://www.addictioncenter.com/addiction/generalized-anxiety-disorder-addiction/). The most common forms of antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Common antidepressants include: - Fluoxetine (Prozac) - Escitalopram (Lexapro) - Paroxetine (Paxil) - Sertraline ([Zoloft](https://www.addictioncenter.com/stimulants/antidepressants/zoloft-addiction-abuse/)) - Duloxetine ([Cymbalta](https://www.addictioncenter.com/stimulants/antidepressants/cymbalta-addiction-abuse/)) Studies show that in the US, in 2018, 13.2% of adults aged 18 and older had used antidepressant medications in the past 30 days. Use was higher among women (17.7%) than men (8.4%). ## How Do Antidepressants Work? Antidepressants work by increasing specific chemicals in the brain, known as neurotransmitters. Serotonin and norepinephrine are the two primary neurotransmitters that affect mood and happiness. Serotonin significantly regulates mood and is often called the “happy hormone,” while norepinephrine plays a role in mood, arousal, and attention. Because it takes a while to increase and build up the amounts of these neurotransmitters in the brain, it can take 4-6 weeks before a person starts to feel the effects of their medication initially. It is essential to be patient and not quit taking your medication because you are not feeling the desired results right away. Paid Advertising. We receive advertising fees from purchases through BetterHelp links. Online Counseling, Insurance Accepted. Get professional help from an online addiction and mental health counselor from BetterHelp. Start receiving support via phone, video, or live-chat. ## Types Of Antidepressants ### SSRIs Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed type of antidepressant. As their name suggests, they regulate the amount of serotonin in the brain by preventing it from metabolizing, thereby increasing the amount. They are usually preferred over other antidepressants because they have fewer side effects. SSRIs include: - Fluoxetine (Prozac) - Sertraline (Zoloft) - Paroxetine (Paxil) - Fluvoxamine (Luvox) - Citalopram (Celexa) - Escitalopram (Lexapro) ### SNRIs Serotonin-norepinephrine reuptake inhibitors (SNRIs) similarly boost mood by interacting with serotonin and norepinephrine in the brain. SNRIs include: - Desvenlafaxine (Pristiq, Khedezla) - Duloxetine (Cymbalta, Irenka) - Levomilnacipran (Fetzima) - Milnacipran (Savella) - Venlafaxine (Effexor XR) ### TCAs Tricyclic antidepressants (TCAs) inhibit the reuptake of serotonin and norepinephrine. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an [overdose](https://www.addictioncenter.com/drugs/overdose/) occurs. They also cause more unpleasant side effects than SSRIs and SNRIs. However, TCAs are sometimes used for people with severe depression who fail to respond to other treatments. TCAs may also be recommended for other mental health conditions, such as OCD, [bipolar disorder](https://www.addictioncenter.com/addiction/bipolar-disorder/), and nerve pain. TCA antidepressants include: - Amitriptyline - Amoxapine - Desipramine (Norpramin) - Doxepin - Imipramine (Tofranil) - Nortriptyline (Pamelor) - Protriptyline - Trimipramine ### Wellbutrin Wellbutrin (bupropion) belongs to a class of medications called aminoketones. It works by increasing your levels of dopamine and norepinephrine. Unlike SSRIs and SNRIs, it does not act on serotonin and does not contribute to antidepressant discontinuation syndrome, which occurs when a person suddenly stops taking their medication. Explore These Featured Centers ## What Are The Side Effects Of Antidepressants? Common side effects of SSRIs and SNRIs include: - Feeling agitated, shaky, or anxious - Indigestion and stomach aches - Diarrhea or constipation - Loss of appetite - Dizziness - Fatigue or difficulty sleeping - Headaches - Decreased sex drive - Difficulties achieving orgasm - Difficulties obtaining or maintaining an erection Common side effects of TCAs include: - Dry mouth - Blurring of vision - Constipation - Problems urinating - Drowsiness - Dizziness - Weight gain - Heart palpitations or fast heartbeat These side effects often improve within a few weeks, so if you are experiencing some of these side effects, you should not stop taking the medication. Instead, talk with your doctor. ## How Are Antidepressants Taken? Antidepressants are usually taken in tablet form and often take 2-4 weeks to work. Most prescribers will follow the general rule of starting with the lowest possible dose thought necessary to improve your symptoms. Still, if you are not feeling any improvement in mood after four weeks, your doctor may recommend increasing the dose or trying a different medication. Sometimes, it takes a couple of tries to determine the correct dosage and medication that works best for you. ## Typical Doses Of Antidepressants There is no “typical dose” as each antidepressant is different, and each person will react differently to different dosages and different medications. Therefore, dosages often vary. For example, 20mg of citalopram can be considered an optimal daily dose, whereas 50mg of sertraline can be considered optimal. However, the efficacy of the antidepressant can max out, meaning that you are on the highest dose for the most benefits. It is possible to add another antidepressant from a different class to your current antidepressant regimen, but this is done with careful consideration and monitoring from your doctor. Care That's Covered by Insurance [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/aetna_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=aetna-insurance-for-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2022/11/cigna_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=cigna-insurance-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2022/11/bluecrossblueshield_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=bluecross-blueshield-insurance-for-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/unitedhealthcare_logo.svg)](http://addictioncenter.com/rehabs/results/?payments=united-healthcare-insurance-addiction-treatment) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/tricare_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=tricare-insurance) [![Insurance Logo](https://www.addictioncenter.com/app/uploads/2021/03/humana_logo.svg)](https://www.addictioncenter.com/rehabs/results/?payments=humana-health-insurance-addiction-treatment) Addiction Center is not affiliated with any insurance. ## What Is Antidepressant Discontinuation Syndrome? Often, people will be on antidepressants long-term (for years) and tolerate some side effects. However, if you want to stop taking antidepressants, it should not be done prematurely or without a thorough discussion with your doctor because your depression can re-emerge. If you and your doctor agree to stop antidepressants, your doctor may slowly wean you off the medication to prevent discontinuation syndrome. Coming off antidepressant medication can cause [antidepressant withdrawal](https://www.addictioncenter.com/stimulants/antidepressants/withdrawal-detox/) and can set you up for a relapse of depression. However, there is a difference between withdrawal (also called antidepressant discontinuation syndrome) and depression relapse. About 20% of people develop antidepressant discontinuation syndrome following an abrupt stoppage of or marked reduction in the dose of an antidepressant after taking it for one month. Discontinuation symptoms can include anxiety and depression, which mimics depression relapse. Discontinuation syndrome also includes physical symptoms such as: - Flu-like symptoms - [Insomnia](https://www.addictioncenter.com/addiction/dual-diagnosis/insomnia/) - Nausea - Dizziness - Abnormal sensations such as tingling and shock-like feeling - Hyperarousal symptoms such as irritability, aggression, and reactivity Discontinuation syndrome happens days to weeks after stopping the antidepressant, and symptoms eventually go away. In contrast, a [relapse](https://www.addictioncenter.com/treatment/chronic-relapse/): - Happens a few weeks after stopping antidepressants - Lasts over one month - Results in worsened depression symptoms Having discontinuation symptoms doesn’t mean you’re addicted to your antidepressant. A person who is addicted craves the drug and often needs increasingly higher doses. Few people who take antidepressants develop a craving or feel a need to increase the amount. ## Alternative Options To Antidepressants Antidepressants, regardless of the class, do carry side effects, and each person reacts differently. Some people switch to another antidepressant with a longer half-life to gradually lower the dosage before stopping medication completely. While this works for some, it’s important to note that only certain practitioners, like psychiatrists and primary care physicians, can prescribe medication. If you are struggling with depression and choose not to use antidepressants or would like to taper off of medication completely, psychotherapy can be an equivalent option, depending on your symptoms and severity. Psychotherapy is often the first-line, non-pharmacological treatment for depression. [Online therapy](https://www.addictioncenter.com/online-therapy/) provides support for those struggling with depression by connecting them with licensed therapists, who utilize different psychotherapy approaches, such as [CBT](https://www.addictioncenter.com/treatment/cognitive-behavioral-therapy/) and [DBT](https://www.addictioncenter.com/treatment/dialectical-behavior-therapy/), to address and treat depressive symptoms. Many people benefit from this form of treatment. If you are interested in the options available to you, explore our [online therapy directory](https://www.addictioncenter.com/online-therapy/) today.
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