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| History drop | PASS | isNull(history_drop_reason) | No drop reason |
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| Property | Value |
|---|---|
| URL | https://www.aarp.org/health/drugs-supplements/paxlovid-covid-treatment-side-effects/ |
| Last Crawled | 2026-03-15 17:49:12 (1 month ago) |
| First Indexed | 2025-03-14 18:29:58 (1 year ago) |
| HTTP Status Code | 200 |
| Meta Title | What Are the Side Effects of Taking Paxlovid for COVID? |
| Meta Description | Many have turned to the pill Paxlovid to help keep a case of COVID-19 from progressing to a severe infection. Learn about the side effects of Paxlovid. |
| Meta Canonical | null |
| Boilerpipe Text | Millions of Americans have turned to the
prescription pill Paxlovid
to help keep a case of COVID-19 from progressing to a severe infection. And researchers say the oral antiviral has saved thousands of lives â as many as 1,500 each week in the U.S., according to a March estimate from the Food and Drug Administration (FDA). Â
While doctors say Paxlovid is well-tolerated by patients, some people can experience side effects when taking it, as is the case with
any medication
. The most common side effectï»żs of Paxlovid include an impaired sense of taste (often a metallic taste) and diarrhea, the FDA reports. People can also experience muscle aches or nausea when taking Paxlovid, says Bruce Farber, M.D., chief of public health and epidemiology at Northwell Health in New Hyde Park, New York.
âBut these [side effects] donât affect everyone,â Farber says. âThereâs probably a very large percentage of people who have no trouble taking it.â
Plus, when you stop taking the medication, which is a five-day course, the side effects subside. And keep in mind that many of these symptoms â change in taste, stomach upset and muscle aches â are among the ones you might see when fighting a case of
COVID-19
anyway, says Nicholas A. Turner, M.D., an infectious disease specialist at Duke Health.
Who Should Take Paxlovid?
According to the Centers for Disease Control and Prevention, COVID-19 treatment is recommended for people who are more likely to get very sick from the virus, including:
Adults age 50 and older (risk increases with age).
People who are unvaccinated or are not up to date on their COVID-19 vaccines.
People with certain medical conditions, such as chronic lung disease, heart disease or a weakened immune system.
If you test positive for COVID-19 and fall into any of these categories, talk to your doctor about treatment options. Time is of the essence: The antivirals work best when started within five days of symptom onset.
The difference is, when youâre taking Paxlovid, youâre significantly less likely to experience some of the more serious symptoms of COVID-19 that could put you in the hospital, such as difficulty breathing. âIt can really make a dramatic difference, and certainly youâd rather have a metallic taste in your mouth than be sick in the hospital,â Farber says.
Does Paxlovid interact with other medications?ï»ż
Where you run into the risk of experiencing more
side effects
, and potentially serious ones, is if youâre already taking a medication that interacts with Paxlovid â and several do, including
common blood pressure
and blood-thinning medications. (See the
full list
on this FDA fact sheet.)
A big reason: Paxlovid, which stops the coronavirus from replicating in the bodyâs cells, can slow down the way your body gets rid of other medicines, Turner says. âIf you cannot clear out another medicine as fast as the body might normally do, you could effectively get an overdose on one of your other medications,â he says.
The key, says Camille Kotton, M.D., clinical director for transplant and immunocompromised host infectious diseases at Massachusetts General Hospital in Boston, is to make sure your health care provider is aware of all the medications you take. âThey should carefully review them for potential, even severe, drug interactions,â she says.
If you are taking a medication that interacts with Paxlovid, that doesnât preclude you from getting the treatment. Your doctor may be able to adjust the dosage of that drug while youâre taking the treatment, or have you temporarily stop it, Turner says.
There are also other antiviral treatments for COVID infections that can be considered, too, including remdesivir, which is administered by IV, and the antiviral pill molnupiravir (Lagevrio), which health officials say can be used if the other two therapies are not good options. |
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# What Are the Side Effects of Paxlovid?
## Hereâs what to expect when you take the prescription COVID-19 treatment
***
By
Rachel Nania,
AARP
11
Comments
[En español](https://www.aarp.org/espanol/salud/farmacos-y-suplementos/info-2023/efectos-secundarios-paxlovid-covid.html)
Published December 01, 2023


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Millions of Americans have turned to the [prescription pill Paxlovid](https://www.aarp.org/health/conditions-treatments/paxlovid-covid-treatment/ "paxlovid for covid treatment") to help keep a case of COVID-19 from progressing to a severe infection. And researchers say the oral antiviral has saved thousands of lives â as many as 1,500 each week in the U.S., according to a March estimate from the Food and Drug Administration (FDA).
While doctors say Paxlovid is well-tolerated by patients, some people can experience side effects when taking it, as is the case with [any medication](https://www.aarp.org/health/drugs-supplements/otc-medications-risky-after-50/ "risky medications after 50"). The most common side effectï»żs of Paxlovid include an impaired sense of taste (often a metallic taste) and diarrhea, the FDA reports. People can also experience muscle aches or nausea when taking Paxlovid, says Bruce Farber, M.D., chief of public health and epidemiology at Northwell Health in New Hyde Park, New York.
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âBut these \[side effects\] donât affect everyone,â Farber says. âThereâs probably a very large percentage of people who have no trouble taking it.â
Plus, when you stop taking the medication, which is a five-day course, the side effects subside. And keep in mind that many of these symptoms â change in taste, stomach upset and muscle aches â are among the ones you might see when fighting a case of [COVID-19](https://www.aarp.org/health/conditions-treatments/coronavirus-facts/ "covid faq") anyway, says Nicholas A. Turner, M.D., an infectious disease specialist at Duke Health.
#### **Who Should Take Paxlovid?**
According to the Centers for Disease Control and Prevention, COVID-19 treatment is recommended for people who are more likely to get very sick from the virus, including:
- Adults age 50 and older (risk increases with age).
- People who are unvaccinated or are not up to date on their COVID-19 vaccines.
- People with certain medical conditions, such as chronic lung disease, heart disease or a weakened immune system.
If you test positive for COVID-19 and fall into any of these categories, talk to your doctor about treatment options. Time is of the essence: The antivirals work best when started within five days of symptom onset.
The difference is, when youâre taking Paxlovid, youâre significantly less likely to experience some of the more serious symptoms of COVID-19 that could put you in the hospital, such as difficulty breathing. âIt can really make a dramatic difference, and certainly youâd rather have a metallic taste in your mouth than be sick in the hospital,â Farber says.
### **Does Paxlovid interact with other medications?ï»ż**
Where you run into the risk of experiencing more [side effects](https://www.aarp.org/health/drugs-supplements/pills-that-raise-blood-pressure/), and potentially serious ones, is if youâre already taking a medication that interacts with Paxlovid â and several do, including [common blood pressure](https://www.aarp.org/health/conditions-treatments/natural-blood-pressure-remedies/ "high blood pressure remedies") and blood-thinning medications. (See the [full list](https://www.fda.gov/media/155050/download "paxlovid medication interaction") on this FDA fact sheet.)
A big reason: Paxlovid, which stops the coronavirus from replicating in the bodyâs cells, can slow down the way your body gets rid of other medicines, Turner says. âIf you cannot clear out another medicine as fast as the body might normally do, you could effectively get an overdose on one of your other medications,â he says.
The key, says Camille Kotton, M.D., clinical director for transplant and immunocompromised host infectious diseases at Massachusetts General Hospital in Boston, is to make sure your health care provider is aware of all the medications you take. âThey should carefully review them for potential, even severe, drug interactions,â she says.
If you are taking a medication that interacts with Paxlovid, that doesnât preclude you from getting the treatment. Your doctor may be able to adjust the dosage of that drug while youâre taking the treatment, or have you temporarily stop it, Turner says.
There are also other antiviral treatments for COVID infections that can be considered, too, including remdesivir, which is administered by IV, and the antiviral pill molnupiravir (Lagevrio), which health officials say can be used if the other two therapies are not good options.


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### **What about Paxlovid rebound?**
Another effect that has been linked to Paxlovid is a phenomenon known as rebound. This is when COVID-19 symptoms abate, only to return a few days later. (Rebound symptoms are almost always brief and mild, health experts stress.)
Rebound doesnât happen to everybody who takes Paxlovid, Turner says, and in fact, research shows it can even happen to people who donât take it.
Kotton says a fear of COVID rebound has kept many people from taking Paxlovid. âBut for me, theyâre missing the bigger picture,â she says, which is that they could get better faster, and significantly lower the likelihood that COVID symptoms turn severe.
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### **Treating your side effects**
To avoid any potentially serious side effects from drug interactions, be sure to tell your doctor all of the medications youâre taking â including [over-the-counter supplements](https://www.aarp.org/health/drugs-supplements/dietary-supplement-side-effects/ "supplement side effects"). (For example, St. Johnâs wort is included on [the list](https://www.fda.gov/media/155050/download "list of potential medical interactions with paxlovid") of medications that interact with Paxlovid.) ï»ż
### Find COVID-19 Vaccines in Your State
AARP's [53 state and territory COVID-19 vaccine guides](https://www.aarp.org/health/conditions-treatments/covid-vaccine-state-guides/ "how and where to get the COVID vaccine in your state") can help you find vaccines near you and provide the latest answers to common questions about costs, eligibility and availability.
If you experience the unpleasant taste in your mouth (âPaxlovid mouth,â as some people call it), try sucking on hard candies, mints or cough drops for the few days youâre taking the medication, Kotton suggests. âAnything that can give a different flavor in your mouth can sometimes be useful,â she says.
And any muscle aches or headaches that come on can be handled with over-the-counter pain relievers, Farber says, though itâs important to check in with your doctor before taking them.
Another tip: Keep the benefits of the treatment in mind. âEvery medicine that we have has its benefits and has its risks. The big benefit for Paxlovid is to prevent what is otherwise an outpatient disease from becoming bad enough to require a hospitalization,â Turner says.
Plus, in addition to lowering the likelihood of hospitalization and death, Paxlovid has been [linked to lower risks for long COVID](https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2802878 "paxlovid long covid"), studies show; itâs even being investigated as a potential treatment for the puzzling condition.
[%{postComment}%](https://www.aarp.org/health/drugs-supplements/paxlovid-covid-treatment-side-effects/#comments_widget_id)
*Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments.*
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[The coronavirus strain is now dominant in the U.S.](https://www.aarp.org/health/conditions-treatments/new-covid-variant-hv-1/)
[ ](https://www.aarp.org/health/drugs-supplements/are-paxlovid-covid-treatments-still-free/ "Are COVID Treatments Still Free?")
[Are COVID Treatments Still Free?](https://www.aarp.org/health/drugs-supplements/are-paxlovid-covid-treatments-still-free/)
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1. #### Comment by ClaudiaB561355.
Cl
ClaudiaB561355
December 7, 2023
I took Paxlovid and it did not work well with my asthma. I had trouble breathing after the first dose, then felt better, took the second dose and had breathing issues. I called my doctor and he didn't think it was the Paxlovid but the Covid, However I felt better again and took a third dose and could not breathe. I stopped taking it. I haven't seen this listed as a side effect, but I wasn't willing to keep on with it.
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2. #### Comment by davidd906936.
da
davidd906936
December 6, 2023
I got Covid on a Cruise in July 2022 and when I got home took PAX--it was a rough 2 weeks that first Covid, but no hospital and no side effects. For our next cruise in Jan 2023, I asked my Doctor to give me PAX to have on hand to take right away if needed. Got my second Covid on that cruise, started PAX on the cruise, was drained about 3 nights, but did not miss any activities and was fine by the time the cruise ended after 10 days. No side effects. Going to take another cruise soon and don't know whether to have more PAX on hand? What are your thoughts?
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- #### Reply by j643476m.
j6
j643476m
December 7, 2023
Reply to davidd906936
Maybe you should stop cruising. It's known that COVID causes organ damage & increases risk of diabetes, among other issues. Is it really worth it? You didn't miss any activities. Are you sure you were no longer contagious when you exposed yourself to others on the cruise?
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3. #### Comment by JerryB154414.
Je
JerryB154414
December 6, 2023
No med. is safe 100%---As long is saving my life that is a big plus for me...
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4. #### Comment by jonjon8566.
jo
jonjon8566
December 6, 2023
I was told early on that I should not take Paxlovid as I have Stage 3 Kidney disease. (I have had it, and it has been stable, for a good twenty-five years.) I did have Covid about two years ago but fortunately it was a relatively mild case and resolved by itself. Looking at the very lengthy FDA drug interaction list together with the FDA statement of various contraindications, it is abundantly clear that you should consult with your doctor before even considering taking Paxlovid.
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5. #### Comment by MichaelW373089.
Mi
MichaelW373089
December 6, 2023
OHhhh forget to say, Covid left me with a gift for 6 weeks...Chest pains which mysteriously disappeared as they appeared. I'm fine now.
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| Readable Markdown | Millions of Americans have turned to the [prescription pill Paxlovid](https://www.aarp.org/health/conditions-treatments/paxlovid-covid-treatment/ "paxlovid for covid treatment") to help keep a case of COVID-19 from progressing to a severe infection. And researchers say the oral antiviral has saved thousands of lives â as many as 1,500 each week in the U.S., according to a March estimate from the Food and Drug Administration (FDA).
While doctors say Paxlovid is well-tolerated by patients, some people can experience side effects when taking it, as is the case with [any medication](https://www.aarp.org/health/drugs-supplements/otc-medications-risky-after-50/ "risky medications after 50"). The most common side effectï»żs of Paxlovid include an impaired sense of taste (often a metallic taste) and diarrhea, the FDA reports. People can also experience muscle aches or nausea when taking Paxlovid, says Bruce Farber, M.D., chief of public health and epidemiology at Northwell Health in New Hyde Park, New York.
âBut these \[side effects\] donât affect everyone,â Farber says. âThereâs probably a very large percentage of people who have no trouble taking it.â
Plus, when you stop taking the medication, which is a five-day course, the side effects subside. And keep in mind that many of these symptoms â change in taste, stomach upset and muscle aches â are among the ones you might see when fighting a case of [COVID-19](https://www.aarp.org/health/conditions-treatments/coronavirus-facts/ "covid faq") anyway, says Nicholas A. Turner, M.D., an infectious disease specialist at Duke Health.
#### **Who Should Take Paxlovid?**
According to the Centers for Disease Control and Prevention, COVID-19 treatment is recommended for people who are more likely to get very sick from the virus, including:
- Adults age 50 and older (risk increases with age).
- People who are unvaccinated or are not up to date on their COVID-19 vaccines.
- People with certain medical conditions, such as chronic lung disease, heart disease or a weakened immune system.
If you test positive for COVID-19 and fall into any of these categories, talk to your doctor about treatment options. Time is of the essence: The antivirals work best when started within five days of symptom onset.
The difference is, when youâre taking Paxlovid, youâre significantly less likely to experience some of the more serious symptoms of COVID-19 that could put you in the hospital, such as difficulty breathing. âIt can really make a dramatic difference, and certainly youâd rather have a metallic taste in your mouth than be sick in the hospital,â Farber says.
### **Does Paxlovid interact with other medications?ï»ż**
Where you run into the risk of experiencing more [side effects](https://www.aarp.org/health/drugs-supplements/pills-that-raise-blood-pressure/), and potentially serious ones, is if youâre already taking a medication that interacts with Paxlovid â and several do, including [common blood pressure](https://www.aarp.org/health/conditions-treatments/natural-blood-pressure-remedies/ "high blood pressure remedies") and blood-thinning medications. (See the [full list](https://www.fda.gov/media/155050/download "paxlovid medication interaction") on this FDA fact sheet.)
A big reason: Paxlovid, which stops the coronavirus from replicating in the bodyâs cells, can slow down the way your body gets rid of other medicines, Turner says. âIf you cannot clear out another medicine as fast as the body might normally do, you could effectively get an overdose on one of your other medications,â he says.
The key, says Camille Kotton, M.D., clinical director for transplant and immunocompromised host infectious diseases at Massachusetts General Hospital in Boston, is to make sure your health care provider is aware of all the medications you take. âThey should carefully review them for potential, even severe, drug interactions,â she says.
If you are taking a medication that interacts with Paxlovid, that doesnât preclude you from getting the treatment. Your doctor may be able to adjust the dosage of that drug while youâre taking the treatment, or have you temporarily stop it, Turner says.
There are also other antiviral treatments for COVID infections that can be considered, too, including remdesivir, which is administered by IV, and the antiviral pill molnupiravir (Lagevrio), which health officials say can be used if the other two therapies are not good options. |
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