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| Meta Title | Can Melatonin Help You Sleep? And Is It Safe? |
| Meta Description | More people use the supplement as a sleep aid, but it doesnât work the same for all and can come with risks including headaches, fatigue and fever. |
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| Boilerpipe Text | Filmstax / Getty Images
A good nightâs sleep is about more than beauty rest. Itâs been linked toÂ
better brain
, heart, and mental health, as well as a lower risk for certain cancers. Yet research suggests that an increasing number of AmericansÂ
are struggling to get those all-important zâs
.
In a 2022 study, researchers tracked a fivefold increase in melatonin use among U.S. adults in the past few decades. Published inÂ
JAMA
, the study found that people take higher doses of the over-the-counter supplement than whatâs typically recommended â despite scant evidence that melatonin works for your run-of-the-mill shut-eye issues, including insomnia.
âWe know that melatonin is often used as a sleep aid, but itâs actually misused as a sleep aid because itâs not a sleep aid,â says Naima Covassin, a coauthor of the study and a sleep disorder expert at Mayo Clinic.
Popping a melatonin pill or gummy before bedtime may help you fall asleep a few minutes faster, Covassin says, but it wonât make much of a difference in the number of times you wake up at night or how many total hours you get. âThereâs actually very little improvement in all of these parameters,â she says.
When does melatonin work?
To understand when melatonin can be beneficial, itâs important to know more about its role in the sleep-wake cycle.
Many consumers are familiar with the bottled version of melatonin â around 6 million U.S. adults reach for it. But melatonin is a naturally occurring hormone the brain produces in response to darkness to help our bodies know when itâs time to go to sleep and when itâs time to be awake.
Side Effects of Melatonin
Short-term use of melatonin may cause mild side effects, including:
Headaches
Dizziness
Nausea
Drowsiness
Less common side effects include:
Short-term feelings of depression
Mild tremor
Mild anxiety
Abdominal cramps
Irritability
Reduced alertness
Confusion or disorientation
Source: Mayo Clinic
When melatonin hits the bloodstream (typically a few hours before bedtime), it reduces alertness and âfacilitates our ability to fall asleep,â explains Dr. David Neubauer, associate professor of psychiatry and behavioral sciences at Johns Hopkins Medicine. It also helps cool off the brain and the body, âwhich helps you sleep better,â says James K. Wyatt, director of the Section of Sleep Disorders and Sleep-Wake Research at Rush University in Chicago. Â
Because melatonin doesnât have the sameÂ
sedating effect
 that many sleep aids provide, taking it in pill form is less helpful on those nights when you canât seem to fall asleep or stay asleep.
Video: 5 Things to Know About Getting Better Sleep
It can work in instances when you want to adjust your biological sleep clock â say, to overcome
jet lag
after traveling through several time zones or to shift your schedule entirely so youâre going to bed a few hours earlier. ï»ż
Melatonin supplements can benefit shift workers who need to sleep during the day, when the bodyâs melatonin levels are naturally low. Thatâs when supplementing with melatonin is âactually quite effective,â Covassin says. ï»ż
In older adults, it may be able to prolong sleep when taken for an extended period, though more research is needed. AÂ
small study
 from researchers at Brigham and Womenâs Hospital in Boston found that when adults ages 55 to 78 took 5 milligrams of melatonin for two weeks, they increased their sleep time by at least 15 minutes, compared with those who took a placebo.Â
Is melatonin safe?
5 tips for getting a better nightâs sleep
 Â
Be consistent: Go to bed at the same time each night, even on weekends.
Make sure your bedroom is quiet, dark, relaxing and at a comfortable temperature.
Remove electronic devices from the bedroom.
Avoid large meals, caffeine and alcohol before bedtime.
Get some exercise: Being active during the day can help you fall asleep at night.
Source: Centers for Disease Control and Prevention ï»ż
Melatonin is generally safe and well-tolerated. But just because itâs available in the U.S. without a prescription and sold alongside multivitamins and probiotics doesnât mean itâs risk-free. (In many countries it can be purchased only by prescription.)
âWe think since itâs available over the counter that itâs harmless, but it may not necessarily be true,â Covassin says. Short-term use of melatonin supplements can come with a list of side effects, especially when taken in high doses, including headaches, dizziness, nausea, fatigue and daytime sleepiness. Vivid dreams and nightmares have also been reported. âThese are mild, but they can also affect your daytime function; think about if you have to drive or if you have to operate machinery,â Covassin points out. ï»ż
The National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health notes that melatonin may remain active in older adults for longer periods, which could lead to daytime drowsiness.Â
More serious, albeit rare, reactions have been linked to melatonin supplements, including changes in heart rate andÂ
blood pressure
, temporaryÂ
feelings of depressionï»ż,
ï»żï»ż seizures and confusion or disorientation. A
new study
, which has not yet been peer reviewed but is being presented at the American Heart Associationâs Scientific Sessions 2025, found that long-term melatonin use was associated with a higher risk of heart failure diagnosis and heart failure hospitalization, though experts say more research is needed to better understand the possible link.
Melatonin has also been shown to affect glucose tolerance, or the bodyâs ability to handle sugar. There are drug interactions to consider, too. Melatonin can increase bleeding risks among people taking anticoagulants and antiplatelet drugs; it can worsen blood pressure in those taking blood pressure medications, and it can stimulate immune function and interfere with immunosuppressive therapy, according to Mayo Clinic.
âSo, obviously, this should be taken with caution,â Covassin says. âAnd thatâs my main recommendation. If you are thinking [about taking melatonin] or if you are already taking melatonin, talk with your provider to determine whether itâs actually appropriate for you.â
Itâs important to know that, as with all dietary supplements in the U.S., federal regulations are less strict for melatonin than they are for over-the-counter medicines and prescription drugs.Â
A 2017 study
 published in theÂ
Journal of Clinical Sleep Medicine
 found that the contents of the majority of melatonin products didnât match what was listed on the label â their concentrations ranged, and so did the presence of other ingredients. ï»ż
Adding to the evidence, a
 study
 published in 2023 in
JAMA
looked at melatonin quantities in 25 sleepÂ
gummy products
, often marketed to children, and found that 22 of them contained different amounts of melatonin than what was declared on the label. The actual quantity of melatonin ranged from 74 percent to 347 percent of the labeled amount; only three products had melatonin levels within 10 percent of the declared quantity.
The American Academy of Sleep Medicine offers a tip: When comparing supplement labels, look for the âUSP Verifiedâ mark, which indicates that the formulation meets the requirements of the U.S. Pharmacopeial Convention.
What can you do if you have trouble sleeping?
Interested in making adjustments to your sleep schedule? Before you reach for a pill, Neubauer recommends trying natural methods. You can do this by getting outside and staying active during the day. âJust getting light makes your circadian rhythm more robust, and the more active you are in the daytime, the better chance you have of sleeping more at nighttime,â he says. Because light suppresses the production of melatonin, keep levels low at night â this means limiting the use of your phone, tablet, computer and TV an hour or two before bed.
If you have trouble sleeping more generally, talk with a doctor to figure out the cause, Wyatt says. âItâs rare when sleep goes bad just on its own and itâs not because of other things, like the side effects of a different medication orÂ
stress or anxiety or depression
 or a pain disorder thatâs insufficiently treated â there are all sorts of things.â
A third of U.S. adults report that they usually get less than the recommended amount of sleep (seven or more hours per night for adults), according to the Centers for Disease Control and Prevention. The good news: ï»żThere are treatments for insomnia,Â
and a successful one
, cognitive behavioral therapy, doesnât come in pill form.
âWeâre starting to realize treating insomnia is not just about getting a better nightâs sleep,â Wyatt says. âItâs to significantly reduce risk for some of these negative health outcomes that could come years to decades later.â Â ï»ż
Melatonin and ChildrenÂ
Melatonin use isnât just increasing among adults â more children are taking it as well.
In fact, the number of pediatric melatonin ingestions increased 530 percent from 2012 to 2021, with the largest yearly increase (about 38 percent) occurring from 2019 to 2020,Â
a recent report
 from the Centers for Disease Control and Prevention (CDC) finds. In 2020, the supplement became the most frequently ingested substance among children reported to national poison control centers â some of these cases required hospitalization.Â
The authors of the CDC report point out that melatonin has become widely available in the U.S. â some childrenâs varieties are even sold in âgummyâ form. Itâs considered a dietary supplement and is subject to less regulatory oversight than other over-the-counter (OTC) medications.Â
âIncreasing use of OTC melatonin in various formulations, lack of robust manufacturing regulations, and varied dosing recommendations can place children at risk for potential adverse events,â the authors write. They call for more research into the causes of increased melatonin ingestions among children and for public health initiatives to raise awareness. âChild-resistant packaging for this supplement should be considered, and health care providers should warn parents about potential toxic consequences of melatonin exposure,â they say.ï»ż
Editorâs note: This article, originally published June 6, 2022, has been updated to reflect new information.
Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments. |
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[Cautionary Tales of Today's Biggest Scams](https://www.aarp.org/podcasts/the-perfect-scam/)
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Healthy Sleep Advice
[Go to Series Main Page](https://www.aarp.org/health/healthy-living/better-sleep-for-better-health/)
- [ Causes of Sleeplessness Health Conditions Linked to Poor Sleep Trouble sleeping can signal serious problems](https://www.aarp.org/health/conditions-treatments/causes-of-sleeplessness/)
- [ Side or Back Whatâs the Best Sleeping Position for Your Health? How you snooze can affect sleep quality, plus brain, heart and stomach health](https://www.aarp.org/health/healthy-living/best-sleeping-position/)
- [ Afternoon Rest 7 Napping Tips for a Refreshing Snooze Happy, healthy napping is just a few bits of advice away](https://www.aarp.org/home-family/your-home/info-2024/napping-tips.html)
- [ Sleep Aids Can Melatonin Help You Sleep? Plus, what you need to know about safety](https://www.aarp.org/health/drugs-supplements/melatonin-and-sleep/)
- [ Deficit Woes Why Missing Sleep Is Worse for Women Than Men Not only do females get less sleep than males, their health suffers more from it](https://www.aarp.org/health/healthy-living/why-sleep-matters-more-for-women/)
- [ Home & Living 7 Napping Tips for a Refreshing Snooze A power nap, a cat nap, an afternoon snooze. Whatever you call it, the concept of a nap is nothing new. But is a quick bit of shut-eye good for you? And when and how often should you take one? For National Napping Day, we talked to the experts to find out.](https://www.aarp.org/home-living/napping-tips/)
- [ Health Smart Sleep Tips for a Refreshing Morning 43 tips to help you fight those restless, endless nights and get the slumber you need](https://www.aarp.org/health/healthy-living/smart-guide-sleep/)
- [ Tossing and Turning Suddenly Canât Sleep? Hereâs What May Be Causing Your Insomnia 14 surprising factors that can sabotage your shut-eye](https://www.aarp.org/health/conditions-treatments/have-trouble-sleeping/)
- [ Hello Darkness Light Can Affect Your Sleep and Health You should not be able to see your hand in your bedroom, experts say](https://www.aarp.org/health/healthy-living/light-affects-sleep-health/)
- [ Sleep Meds 10 Medications That Can Mess With Your Sleep Trouble sleeping? These drugs may be to blame](https://www.aarp.org/health/drugs-supplements/medications-that-can-cause-insomnia/)
- [ Shuteye on Trips 6 Tips for Getting Better Sleep While Traveling A good nightâs sleep on vacation can start before you leave home](https://www.aarp.org/travel/travel-tips/lodging/info-2023/tips-for-better-sleep-while-on-vacation.html)
- [ Sleep Hygiene How to Create a Sleep Sanctuary and Other Tips for a Good Night's Sleep 13 habits to give your body the rest it needs](https://www.aarp.org/health/healthy-living/good-sleeping-habits/)
- [ Staying Sharp 3 Things to Know About Sleep and Your Brain Why a good nightâs rest is good medicine](https://stayingsharp.aarp.org/articles/sleep-deprivation-loss/)
- [ Stay Asleep 6 Simple Strategies for Sleeping Through the Night Tips for getting the deep sleep you need. Plus, how to get back to sleep if you wake in the wee hours](https://www.aarp.org/health/healthy-living/how-to-sleep-through-the-night/)
- [ Sweet Dreams What Goes On in the Brain When We Dream? Plus, when they happen during sleep and how they evolve as we age](https://www.aarp.org/health/healthy-living/what-happens-when-we-dream/)
- [ The Right Amount Can You Get Too Much Sleep? Researchers say seven hours per night is ideal](https://www.aarp.org/health/healthy-living/healthy-sleeping-tips/)
- [ Side Effects 3 Reasons to Avoid Sleeping Pills Sleep medication use is on the rise, especially in older adults](https://www.aarp.org/health/conditions-treatments/reasons-to-avoid-sleeping-pills/)
- [ Staying Sharp Make Sleep Your Superpower Learn how to overcome the barriers to a good night's rest with our new sleep challenge](https://stayingsharp.aarp.org/themes/sleep/)
- [ Staying Sharp A Healthy Diet May Be Linked to Better Sleep More fruits and veggies â and fewer sugary drinks â could help you catch your 40 winks](https://stayingsharp.aarp.org/articles/healthy-diet-better-sleep/)
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- [ Staying Sharp Too Stressed for Sleep? Here's What May Help Studies suggest losing good slumber may take a toll on the brain and body](https://stayingsharp.aarp.org/articles/stressed-sleep/)
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# Melatonin for Sleep: Does It Work, and Is It Safe?
## The popular supplement comes with side effects ï»żand questions about its effectiveness
***
By
Rachel Nania,
Updated November 05, 2025
AARP
Comments
[En español](https://www.aarp.org/espanol/salud/farmacos-y-suplementos/info-2022/melatonina-para-dormir.html)
Published June 05, 2022
/ Updated November 05, 2025


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A good nightâs sleep is about more than beauty rest. Itâs been linked to [better brain](https://www.aarp.org/health/brain-health/), heart, and mental health, as well as a lower risk for certain cancers. Yet research suggests that an increasing number of Americans [are struggling to get those all-important zâs](https://jamanetwork.com/journals/jama/fullarticle/2788539 "americans trouble sleeping").
In a 2022 study, researchers tracked a fivefold increase in melatonin use among U.S. adults in the past few decades. Published in *JAMA*, the study found that people take higher doses of the over-the-counter supplement than whatâs typically recommended â despite scant evidence that melatonin works for your run-of-the-mill shut-eye issues, including insomnia.
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âWe know that melatonin is often used as a sleep aid, but itâs actually misused as a sleep aid because itâs not a sleep aid,â says Naima Covassin, a coauthor of the study and a sleep disorder expert at Mayo Clinic.
Popping a melatonin pill or gummy before bedtime may help you fall asleep a few minutes faster, Covassin says, but it wonât make much of a difference in the number of times you wake up at night or how many total hours you get. âThereâs actually very little improvement in all of these parameters,â she says.
### **When does melatonin work?**
To understand when melatonin can be beneficial, itâs important to know more about its role in the sleep-wake cycle.
Many consumers are familiar with the bottled version of melatonin â around 6 million U.S. adults reach for it. But melatonin is a naturally occurring hormone the brain produces in response to darkness to help our bodies know when itâs time to go to sleep and when itâs time to be awake.
#### **Side Effects of Melatonin**
Short-term use of melatonin may cause mild side effects, including:
- Headaches
- Dizziness
- Nausea
- Drowsiness
Less common side effects include:
- Short-term feelings of depression
- Mild tremor
- Mild anxiety
- Abdominal cramps
- Irritability
- Reduced alertness
- Confusion or disorientation
*Source: Mayo Clinic*
When melatonin hits the bloodstream (typically a few hours before bedtime), it reduces alertness and âfacilitates our ability to fall asleep,â explains Dr. David Neubauer, associate professor of psychiatry and behavioral sciences at Johns Hopkins Medicine. It also helps cool off the brain and the body, âwhich helps you sleep better,â says James K. Wyatt, director of the Section of Sleep Disorders and Sleep-Wake Research at Rush University in Chicago.
Because melatonin doesnât have the same [sedating effect](https://www.aarp.org/health/conditions-treatments/reasons-to-avoid-sleeping-pills/) that many sleep aids provide, taking it in pill form is less helpful on those nights when you canât seem to fall asleep or stay asleep.


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5 Things to Know About Getting Better Sleep
Sleep is vital for the overall health of older adults but it can get harder with age. Here are some tips to help your nighttime slumber.
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Video: 5 Things to Know About Getting Better Sleep
It can work in instances when you want to adjust your biological sleep clock â say, to overcome [jet lag](https://www.aarp.org/travel/travel-tips/lodging/tips-for-better-sleep-while-on-vacation/ "better sleep on vacation") after traveling through several time zones or to shift your schedule entirely so youâre going to bed a few hours earlier. ï»ż
Melatonin supplements can benefit shift workers who need to sleep during the day, when the bodyâs melatonin levels are naturally low. Thatâs when supplementing with melatonin is âactually quite effective,â Covassin says. ï»ż
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In older adults, it may be able to prolong sleep when taken for an extended period, though more research is needed. A [small study](https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12801) from researchers at Brigham and Womenâs Hospital in Boston found that when adults ages 55 to 78 took 5 milligrams of melatonin for two weeks, they increased their sleep time by at least 15 minutes, compared with those who took a placebo.
### **Is melatonin safe?**
#### **5 tips for getting a better nightâs sleep**
- Be consistent: Go to bed at the same time each night, even on weekends.
- Make sure your bedroom is quiet, dark, relaxing and at a comfortable temperature.
- Remove electronic devices from the bedroom.
- Avoid large meals, caffeine and alcohol before bedtime.
- Get some exercise: Being active during the day can help you fall asleep at night.
*Source: Centers for Disease Control and Prevention ï»ż*
Melatonin is generally safe and well-tolerated. But just because itâs available in the U.S. without a prescription and sold alongside multivitamins and probiotics doesnât mean itâs risk-free. (In many countries it can be purchased only by prescription.)
âWe think since itâs available over the counter that itâs harmless, but it may not necessarily be true,â Covassin says. Short-term use of melatonin supplements can come with a list of side effects, especially when taken in high doses, including headaches, dizziness, nausea, fatigue and daytime sleepiness. Vivid dreams and nightmares have also been reported. âThese are mild, but they can also affect your daytime function; think about if you have to drive or if you have to operate machinery,â Covassin points out. ï»ż
The National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health notes that melatonin may remain active in older adults for longer periods, which could lead to daytime drowsiness.
More serious, albeit rare, reactions have been linked to melatonin supplements, including changes in heart rate and [blood pressure](https://www.aarp.org/health/conditions-treatments/high-blood-pressure-symptoms-and-causes/), temporary [feelings of depressionï»ż,](https://www.aarp.org/health/conditions-treatments/depression-facts/)ï»żï»ż seizures and confusion or disorientation. A [new study](https://newsroom.heart.org/news/long-term-use-of-melatonin-supplements-to-support-sleep-may-have-negative-health-effects), which has not yet been peer reviewed but is being presented at the American Heart Associationâs Scientific Sessions 2025, found that long-term melatonin use was associated with a higher risk of heart failure diagnosis and heart failure hospitalization, though experts say more research is needed to better understand the possible link.
Melatonin has also been shown to affect glucose tolerance, or the bodyâs ability to handle sugar. There are drug interactions to consider, too. Melatonin can increase bleeding risks among people taking anticoagulants and antiplatelet drugs; it can worsen blood pressure in those taking blood pressure medications, and it can stimulate immune function and interfere with immunosuppressive therapy, according to Mayo Clinic.
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âSo, obviously, this should be taken with caution,â Covassin says. âAnd thatâs my main recommendation. If you are thinking \[about taking melatonin\] or if you are already taking melatonin, talk with your provider to determine whether itâs actually appropriate for you.â
Itâs important to know that, as with all dietary supplements in the U.S., federal regulations are less strict for melatonin than they are for over-the-counter medicines and prescription drugs. [A 2017 study](https://jcsm.aasm.org/doi/10.5664/jcsm.6462) published in the *Journal of Clinical Sleep Medicine* found that the contents of the majority of melatonin products didnât match what was listed on the label â their concentrations ranged, and so did the presence of other ingredients. ï»ż
Adding to the evidence, a [study](https://jamanetwork.com/journals/jama/fullarticle/2804077) published in 2023 in *JAMA* looked at melatonin quantities in 25 sleep [gummy products](https://www.aarp.org/health/drugs-supplements/melatonin-gummies-may-have-dangerous-level-of-hormone/), often marketed to children, and found that 22 of them contained different amounts of melatonin than what was declared on the label. The actual quantity of melatonin ranged from 74 percent to 347 percent of the labeled amount; only three products had melatonin levels within 10 percent of the declared quantity.
The American Academy of Sleep Medicine offers a tip: When comparing supplement labels, look for the âUSP Verifiedâ mark, which indicates that the formulation meets the requirements of the U.S. Pharmacopeial Convention.
### **What can you do if you have trouble sleeping?**
Interested in making adjustments to your sleep schedule? Before you reach for a pill, Neubauer recommends trying natural methods. You can do this by getting outside and staying active during the day. âJust getting light makes your circadian rhythm more robust, and the more active you are in the daytime, the better chance you have of sleeping more at nighttime,â he says. Because light suppresses the production of melatonin, keep levels low at night â this means limiting the use of your phone, tablet, computer and TV an hour or two before bed.
If you have trouble sleeping more generally, talk with a doctor to figure out the cause, Wyatt says. âItâs rare when sleep goes bad just on its own and itâs not because of other things, like the side effects of a different medication or [stress or anxiety or depression](https://www.aarp.org/health/brain-health/anxiety-and-depression/#anxiety-and-depression//) or a pain disorder thatâs insufficiently treated â there are all sorts of things.â
A third of U.S. adults report that they usually get less than the recommended amount of sleep (seven or more hours per night for adults), according to the Centers for Disease Control and Prevention. The good news: ï»żThere are treatments for insomnia, [and a successful one](https://www.aarp.org/health/conditions-treatments/talk-therapy-for-insomnia/), cognitive behavioral therapy, doesnât come in pill form.
âWeâre starting to realize treating insomnia is not just about getting a better nightâs sleep,â Wyatt says. âItâs to significantly reduce risk for some of these negative health outcomes that could come years to decades later.â ï»ż
#### **Melatonin and Children**
Melatonin use isnât just increasing among adults â more children are taking it as well.
In fact, the number of pediatric melatonin ingestions increased 530 percent from 2012 to 2021, with the largest yearly increase (about 38 percent) occurring from 2019 to 2020, [a recent report](https://www.cdc.gov/mmwr/volumes/71/wr/mm7122a1.htm "melatonin and poisonings") from the Centers for Disease Control and Prevention (CDC) finds. In 2020, the supplement became the most frequently ingested substance among children reported to national poison control centers â some of these cases required hospitalization.
The authors of the CDC report point out that melatonin has become widely available in the U.S. â some childrenâs varieties are even sold in âgummyâ form. Itâs considered a dietary supplement and is subject to less regulatory oversight than other over-the-counter (OTC) medications.
âIncreasing use of OTC melatonin in various formulations, lack of robust manufacturing regulations, and varied dosing recommendations can place children at risk for potential adverse events,â the authors write. They call for more research into the causes of increased melatonin ingestions among children and for public health initiatives to raise awareness. âChild-resistant packaging for this supplement should be considered, and health care providers should warn parents about potential toxic consequences of melatonin exposure,â they say.ï»ż
*Editorâs note: This article, originally published June 6, 2022, has been updated to reflect new information.*
[%{postComment}%](https://www.aarp.org/health/drugs-supplements/melatonin-and-sleep/#comments_widget_id)
*Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments.*
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| Readable Markdown | 

Filmstax / Getty Images
A good nightâs sleep is about more than beauty rest. Itâs been linked to [better brain](https://www.aarp.org/health/brain-health/), heart, and mental health, as well as a lower risk for certain cancers. Yet research suggests that an increasing number of Americans [are struggling to get those all-important zâs](https://jamanetwork.com/journals/jama/fullarticle/2788539 "americans trouble sleeping").
In a 2022 study, researchers tracked a fivefold increase in melatonin use among U.S. adults in the past few decades. Published in *JAMA*, the study found that people take higher doses of the over-the-counter supplement than whatâs typically recommended â despite scant evidence that melatonin works for your run-of-the-mill shut-eye issues, including insomnia.
âWe know that melatonin is often used as a sleep aid, but itâs actually misused as a sleep aid because itâs not a sleep aid,â says Naima Covassin, a coauthor of the study and a sleep disorder expert at Mayo Clinic.
Popping a melatonin pill or gummy before bedtime may help you fall asleep a few minutes faster, Covassin says, but it wonât make much of a difference in the number of times you wake up at night or how many total hours you get. âThereâs actually very little improvement in all of these parameters,â she says.
### **When does melatonin work?**
To understand when melatonin can be beneficial, itâs important to know more about its role in the sleep-wake cycle.
Many consumers are familiar with the bottled version of melatonin â around 6 million U.S. adults reach for it. But melatonin is a naturally occurring hormone the brain produces in response to darkness to help our bodies know when itâs time to go to sleep and when itâs time to be awake.
#### **Side Effects of Melatonin**
Short-term use of melatonin may cause mild side effects, including:
- Headaches
- Dizziness
- Nausea
- Drowsiness
Less common side effects include:
- Short-term feelings of depression
- Mild tremor
- Mild anxiety
- Abdominal cramps
- Irritability
- Reduced alertness
- Confusion or disorientation
*Source: Mayo Clinic*
When melatonin hits the bloodstream (typically a few hours before bedtime), it reduces alertness and âfacilitates our ability to fall asleep,â explains Dr. David Neubauer, associate professor of psychiatry and behavioral sciences at Johns Hopkins Medicine. It also helps cool off the brain and the body, âwhich helps you sleep better,â says James K. Wyatt, director of the Section of Sleep Disorders and Sleep-Wake Research at Rush University in Chicago.
Because melatonin doesnât have the same [sedating effect](https://www.aarp.org/health/conditions-treatments/reasons-to-avoid-sleeping-pills/) that many sleep aids provide, taking it in pill form is less helpful on those nights when you canât seem to fall asleep or stay asleep.
Video: 5 Things to Know About Getting Better Sleep
It can work in instances when you want to adjust your biological sleep clock â say, to overcome [jet lag](https://www.aarp.org/travel/travel-tips/lodging/tips-for-better-sleep-while-on-vacation/ "better sleep on vacation") after traveling through several time zones or to shift your schedule entirely so youâre going to bed a few hours earlier. ï»ż
Melatonin supplements can benefit shift workers who need to sleep during the day, when the bodyâs melatonin levels are naturally low. Thatâs when supplementing with melatonin is âactually quite effective,â Covassin says. ï»ż
In older adults, it may be able to prolong sleep when taken for an extended period, though more research is needed. A [small study](https://onlinelibrary.wiley.com/doi/full/10.1111/jpi.12801) from researchers at Brigham and Womenâs Hospital in Boston found that when adults ages 55 to 78 took 5 milligrams of melatonin for two weeks, they increased their sleep time by at least 15 minutes, compared with those who took a placebo.
### **Is melatonin safe?**
#### **5 tips for getting a better nightâs sleep**
- Be consistent: Go to bed at the same time each night, even on weekends.
- Make sure your bedroom is quiet, dark, relaxing and at a comfortable temperature.
- Remove electronic devices from the bedroom.
- Avoid large meals, caffeine and alcohol before bedtime.
- Get some exercise: Being active during the day can help you fall asleep at night.
*Source: Centers for Disease Control and Prevention ï»ż*
Melatonin is generally safe and well-tolerated. But just because itâs available in the U.S. without a prescription and sold alongside multivitamins and probiotics doesnât mean itâs risk-free. (In many countries it can be purchased only by prescription.)
âWe think since itâs available over the counter that itâs harmless, but it may not necessarily be true,â Covassin says. Short-term use of melatonin supplements can come with a list of side effects, especially when taken in high doses, including headaches, dizziness, nausea, fatigue and daytime sleepiness. Vivid dreams and nightmares have also been reported. âThese are mild, but they can also affect your daytime function; think about if you have to drive or if you have to operate machinery,â Covassin points out. ï»ż
The National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health notes that melatonin may remain active in older adults for longer periods, which could lead to daytime drowsiness.
More serious, albeit rare, reactions have been linked to melatonin supplements, including changes in heart rate and [blood pressure](https://www.aarp.org/health/conditions-treatments/high-blood-pressure-symptoms-and-causes/), temporary [feelings of depressionï»ż,](https://www.aarp.org/health/conditions-treatments/depression-facts/)ï»żï»ż seizures and confusion or disorientation. A [new study](https://newsroom.heart.org/news/long-term-use-of-melatonin-supplements-to-support-sleep-may-have-negative-health-effects), which has not yet been peer reviewed but is being presented at the American Heart Associationâs Scientific Sessions 2025, found that long-term melatonin use was associated with a higher risk of heart failure diagnosis and heart failure hospitalization, though experts say more research is needed to better understand the possible link.
Melatonin has also been shown to affect glucose tolerance, or the bodyâs ability to handle sugar. There are drug interactions to consider, too. Melatonin can increase bleeding risks among people taking anticoagulants and antiplatelet drugs; it can worsen blood pressure in those taking blood pressure medications, and it can stimulate immune function and interfere with immunosuppressive therapy, according to Mayo Clinic.
âSo, obviously, this should be taken with caution,â Covassin says. âAnd thatâs my main recommendation. If you are thinking \[about taking melatonin\] or if you are already taking melatonin, talk with your provider to determine whether itâs actually appropriate for you.â
Itâs important to know that, as with all dietary supplements in the U.S., federal regulations are less strict for melatonin than they are for over-the-counter medicines and prescription drugs. [A 2017 study](https://jcsm.aasm.org/doi/10.5664/jcsm.6462) published in the *Journal of Clinical Sleep Medicine* found that the contents of the majority of melatonin products didnât match what was listed on the label â their concentrations ranged, and so did the presence of other ingredients. ï»ż
Adding to the evidence, a [study](https://jamanetwork.com/journals/jama/fullarticle/2804077) published in 2023 in *JAMA* looked at melatonin quantities in 25 sleep [gummy products](https://www.aarp.org/health/drugs-supplements/melatonin-gummies-may-have-dangerous-level-of-hormone/), often marketed to children, and found that 22 of them contained different amounts of melatonin than what was declared on the label. The actual quantity of melatonin ranged from 74 percent to 347 percent of the labeled amount; only three products had melatonin levels within 10 percent of the declared quantity.
The American Academy of Sleep Medicine offers a tip: When comparing supplement labels, look for the âUSP Verifiedâ mark, which indicates that the formulation meets the requirements of the U.S. Pharmacopeial Convention.
### **What can you do if you have trouble sleeping?**
Interested in making adjustments to your sleep schedule? Before you reach for a pill, Neubauer recommends trying natural methods. You can do this by getting outside and staying active during the day. âJust getting light makes your circadian rhythm more robust, and the more active you are in the daytime, the better chance you have of sleeping more at nighttime,â he says. Because light suppresses the production of melatonin, keep levels low at night â this means limiting the use of your phone, tablet, computer and TV an hour or two before bed.
If you have trouble sleeping more generally, talk with a doctor to figure out the cause, Wyatt says. âItâs rare when sleep goes bad just on its own and itâs not because of other things, like the side effects of a different medication or [stress or anxiety or depression](https://www.aarp.org/health/brain-health/anxiety-and-depression/#anxiety-and-depression//) or a pain disorder thatâs insufficiently treated â there are all sorts of things.â
A third of U.S. adults report that they usually get less than the recommended amount of sleep (seven or more hours per night for adults), according to the Centers for Disease Control and Prevention. The good news: ï»żThere are treatments for insomnia, [and a successful one](https://www.aarp.org/health/conditions-treatments/talk-therapy-for-insomnia/), cognitive behavioral therapy, doesnât come in pill form.
âWeâre starting to realize treating insomnia is not just about getting a better nightâs sleep,â Wyatt says. âItâs to significantly reduce risk for some of these negative health outcomes that could come years to decades later.â ï»ż
#### **Melatonin and Children**
Melatonin use isnât just increasing among adults â more children are taking it as well.
In fact, the number of pediatric melatonin ingestions increased 530 percent from 2012 to 2021, with the largest yearly increase (about 38 percent) occurring from 2019 to 2020, [a recent report](https://www.cdc.gov/mmwr/volumes/71/wr/mm7122a1.htm "melatonin and poisonings") from the Centers for Disease Control and Prevention (CDC) finds. In 2020, the supplement became the most frequently ingested substance among children reported to national poison control centers â some of these cases required hospitalization.
The authors of the CDC report point out that melatonin has become widely available in the U.S. â some childrenâs varieties are even sold in âgummyâ form. Itâs considered a dietary supplement and is subject to less regulatory oversight than other over-the-counter (OTC) medications.
âIncreasing use of OTC melatonin in various formulations, lack of robust manufacturing regulations, and varied dosing recommendations can place children at risk for potential adverse events,â the authors write. They call for more research into the causes of increased melatonin ingestions among children and for public health initiatives to raise awareness. âChild-resistant packaging for this supplement should be considered, and health care providers should warn parents about potential toxic consequences of melatonin exposure,â they say.ï»ż
*Editorâs note: This article, originally published June 6, 2022, has been updated to reflect new information.*
*Rachel Nania is an award-winning health editor and writer at AARP.org, who covers a range of topics including diseases and treatments.* |
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