🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 160 (from laksa042)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa160.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://wexnermedical.osu.edu/our-stories/no-side-effects-from-vaccine\')), getAhrefsUnparsedNoserviceFromURL(\'https://wexnermedical.osu.edu/our-stories/no-side-effects-from-vaccine\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/wexnermedical.osu.edu\/our-stories\/no-side-effects-from-vaccine","crawl_time":1774498474,"first_indexed_time":0,"http_code":200,"src_unparsed":"edu,osu!wexnermedical,\/our-stories\/no-side-effects-from-vaccine s443","src_root_hash":"4014355313726641160","history_drop_reason":null,"meta_title":"No reaction to COVID-19 vaccine? No problem – it’s still working | Ohio State Medical Center","meta_descriptions":["You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working? Learn more from an Ohio State expert."],"attrs_boilerpipe_text":"May 18, 2021\n \nOn Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. \nFind our most recent COVID-19 blog posts here\n.\n You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working?\nThese are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue.\nHow does the vaccine work?\nFor the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells.\nWhy might there not be a reaction?\nIt’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune\/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not.\nCan medication affect side effects?\nBecause reactions after the vaccine are related to an immune response\/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort.\nThe bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all.\nDr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center.\nVisit\nOhio State Health & Discovery\nfor more stories on health, wellness, innovation, research and science news from the experts at Ohio State.\nCheck out health.osu.edu","attrs_markdown":"[Skip to main content](https:\/\/wexnermedical.osu.edu\/our-stories\/no-side-effects-from-vaccine#page-content)\n\nOpen mobile navigation\n\nClose mobile navigation\n\n[![The Ohio State University Wexner Medical Center logo](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/logos\/osuwmclogolargertext2x.png?la=en&hash=5E605FF03C6D5CE8A919C9B589C6B8E7)](https:\/\/wexnermedical.osu.edu\/)\n\n- [Patient Care](https:\/\/wexnermedical.osu.edu\/)\n- [Academics & Research](https:\/\/wexnermedical.osu.edu\/academics-research)\n\n- [Find a Doctor](https:\/\/wexnermedical.osu.edu\/find-a-doctor)\n- [Treatment & Services](https:\/\/wexnermedical.osu.edu\/healthcare-services)\n  Treatment & Services, expand\n  - 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[Nutrition Services](https:\/\/wexnermedical.osu.edu\/nutrition-services)\n    - [Obstetrics & Gynecology](https:\/\/wexnermedical.osu.edu\/obstetrics-gynecology)\n    - [Palliative Care](https:\/\/wexnermedical.osu.edu\/palliative-care)\n    - [Pancreas Care](https:\/\/wexnermedical.osu.edu\/pancreas-care)\n    - [Pharmacy](https:\/\/wexnermedical.osu.edu\/pharmacy)\n    - [Physical Therapy & Rehabilitation](https:\/\/wexnermedical.osu.edu\/physical-therapy-rehabilitation)\n    - [Plastic Surgery](https:\/\/wexnermedical.osu.edu\/plastic-surgery)\n    - [Skin Care Dermatology](https:\/\/wexnermedical.osu.edu\/skin-care-dermatology)\n    - [Sleep Disorders](https:\/\/wexnermedical.osu.edu\/sleep-disorders)\n    - [Substance Use Disorder](https:\/\/wexnermedical.osu.edu\/mental-behavioral\/substance-use-disorder-addiction-treatment)\n    - [Urology](https:\/\/wexnermedical.osu.edu\/urology)\n    - [Weight Management](https:\/\/wexnermedical.osu.edu\/weight-management)\n    - [Wound Healing](https:\/\/wexnermedical.osu.edu\/wound-healing)\n    - [View All](https:\/\/wexnermedical.osu.edu\/healthcare-services)\n- [Locations](https:\/\/wexnermedical.osu.edu\/locations)\n- [Patient & Visitor Guide](https:\/\/wexnermedical.osu.edu\/patient-and-visitor-guide)\n- [Health Equity](https:\/\/wexnermedical.osu.edu\/health-equity)\n  Health Equity, expand\n  - Health Equity\n    Health Equity, expand\n    - [Strategic Approach](https:\/\/wexnermedical.osu.edu\/health-equity\/our-strategic-approach)\n    - [Team and Advisory Board](https:\/\/wexnermedical.osu.edu\/health-equity\/team-and-advisory-board)\n  - Community Programs\n    Community Programs, expand\n    - [Urban Health](https:\/\/wexnermedical.osu.edu\/health-equity\/urban-health)\n    - [Rural and State Health](https:\/\/wexnermedical.osu.edu\/health-equity\/rural-and-state-health)\n    - [National and Global Health](https:\/\/wexnermedical.osu.edu\/health-equity\/national-and-global-health)\n    - [Mental and Behavioral Health and Substance Use Disorder](https:\/\/wexnermedical.osu.edu\/health-equity\/mental-and-behavioral-health-and-substance-use-disorder)\n    - [Maternal and Infant Health](https:\/\/wexnermedical.osu.edu\/health-equity\/maternal-and-infant-health)\n    - [Access to Care](https:\/\/wexnermedical.osu.edu\/health-equity\/access-to-care)\n    - [Nutrition and Food Security](https:\/\/wexnermedical.osu.edu\/health-equity\/nutrition-and-food-security)\n    - [Digital Health Equity](https:\/\/wexnermedical.osu.edu\/health-equity\/digital-health-equity)\n    - [Healthy Community Center](https:\/\/wexnermedical.osu.edu\/health-equity\/healthy-community-center)\n  - Classes and Events\n    Classes and Events, expand\n    - [Weight Management Classes](https:\/\/wexnermedical.osu.edu\/weight-management)\n- [About Us](https:\/\/wexnermedical.osu.edu\/about-us)\n  About Us, expand\n  - Who We Are\n    Who We Are, expand\n    - [Why Choose Us](https:\/\/wexnermedical.osu.edu\/about-us\/why-choose-ohio-state)\n    - [Our Mission](https:\/\/wexnermedical.osu.edu\/about-us\/our-mission)\n    - [Our People](https:\/\/wexnermedical.osu.edu\/about-us\/our-people)\n    - 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[Urgent Care](https:\/\/wexnermedical.osu.edu\/urgent-care)\n  - [Emergency Care](https:\/\/wexnermedical.osu.edu\/emergency-trauma)\n  - [Telehealth](https:\/\/wexnermedical.osu.edu\/telehealth)\n  - [Primary Care](https:\/\/wexnermedical.osu.edu\/primary-care)\n  - [Brain Spine Neuro](https:\/\/wexnermedical.osu.edu\/brain-spine-neuro)\n  - [Cancer](https:\/\/cancer.osu.edu\/)\n  - [Heart & Vascular](https:\/\/wexnermedical.osu.edu\/heart-vascular)\n  - [Laboratory Services](https:\/\/wexnermedical.osu.edu\/laboratory-services)\n  - [Orthopedics](https:\/\/wexnermedical.osu.edu\/orthopedics)\n  - [Sports Medicine](https:\/\/wexnermedical.osu.edu\/orthopedics\/sports-medicine)\n  - [Transplant](https:\/\/wexnermedical.osu.edu\/transplant)\n  - [Second Opinion](https:\/\/wexnermedical.osu.edu\/second-opinion)\n  - [View All](https:\/\/wexnermedical.osu.edu\/healthcare-services)\n  \n  ## Popular Services\n  - [Aesthetics](https:\/\/wexnermedical.osu.edu\/aesthetics)\n  - [Allergy Immunology Care](https:\/\/wexnermedical.osu.edu\/ear-nose-throat\/allergy-immunology-care)\n  - 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We're leading the way.\n  [About Us](https:\/\/wexnermedical.osu.edu\/about-us)\n  \n  ## Who We Are\n  - [Why Choose Us](https:\/\/wexnermedical.osu.edu\/about-us\/why-choose-ohio-state)\n  - [Our Mission](https:\/\/wexnermedical.osu.edu\/about-us\/our-mission)\n  - [Our People](https:\/\/wexnermedical.osu.edu\/about-us\/our-people)\n  - [Our Stories](https:\/\/wexnermedical.osu.edu\/our-stories-redirect)\n  - [Our Facilities](https:\/\/wexnermedical.osu.edu\/about-us\/our-facilities)\n  - [Quality and Safety](https:\/\/wexnermedical.osu.edu\/about-us\/quality-and-safety)\n  - [Rankings and Awards](https:\/\/wexnermedical.osu.edu\/about-us\/rankings-and-awards)\n  - [Sustainability](https:\/\/wexnermedical.osu.edu\/about-us\/sustainability)\n  \n  ## Featured Initiatives\n  - [Strategic Plan](https:\/\/wexnermedical.osu.edu\/about-us\/strategic-plan)\n  - [U.S. News & World Report](https:\/\/wexnermedical.osu.edu\/about-us\/us-news)\n  - [Healthy State Alliance](https:\/\/wexnermedical.osu.edu\/health-equity\/healthy-state-alliance)\n  \n  ## Helpful Resources\n  - [Mobile Apps](https:\/\/wexnermedical.osu.edu\/features\/myhealth)\n  - [Social Media](https:\/\/wexnermedical.osu.edu\/about-us\/social-media)\n  - [Patient Experience](https:\/\/wexnermedical.osu.edu\/about-us\/quality-and-safety)\n  - [Vendor Interactions](https:\/\/wexnermedical.osu.edu\/utility\/footer\/vendor-interaction)\n  - [Contact Us](https:\/\/wexnermedical.osu.edu\/contact-us)\n- [Refer a Patient](https:\/\/wexnermedical.osu.edu\/healthcare-professionals\/refer-a-patient)\n\nOpen Search\n\n# No reaction to COVID-19 vaccine? No problem – it’s still working\nAuthor: [Ashley Lipps, MD](https:\/\/wexnermedical.osu.edu\/our-stories\/#\/author\/Ashley%20Lipps,%20MD)\n\nTopics:\n\n- [Health and Wellness](https:\/\/wexnermedical.osu.edu\/our-stories\/#\/topic\/Health%20and%20Wellness)\n- [Coronavirus](https:\/\/wexnermedical.osu.edu\/our-stories\/#\/topic\/Coronavirus)\n\nMay 18, 2021\n\n![nosideeffects\\_large](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/2021-stories\/05\/no-side-effects-from-vaccine\/nosideeffects_large.jpg)\n\n***On Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. [Find our most recent COVID-19 blog posts here](https:\/\/wexnermedical.osu.edu\/blog#\/topic\/Coronavirus).***\n\nYou’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working?\n\nThese are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue.\n\n## How does the vaccine work?\nFor the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells.\n\n## Why might there not be a reaction?\nIt’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune\/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not.\n\n## Can medication affect side effects?\nBecause reactions after the vaccine are related to an immune response\/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort.  \n   \n The bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all.   \n   \n *Dr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center.*\n\n- [Ready to get vaccinated? We have appointments available as early as today.Get vaccinated](https:\/\/wexnermedical.osu.edu\/infectious-diseases\/covid-19\/schedule-your-vaccine)\n\n## More from Ohio State\n[![U.S. Sen. Sherrod Brown standing with members from the Ohio National Guard and the Ohio State Wexner Medical Center](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/2022-stories\/01\/sen-brown\/sen_brown.jpg) Sen. Brown tours COVID-19 testing site at CAS Sen. Brown talks with members of the Ohio National Guard who’ve joined health care workers across the state on the front lines in the battle against COVID-19.](https:\/\/wexnermedical.osu.edu\/our-stories\/sen-brown-tours-covid-19-testing-site-at-cas)\n\n[![Andrew Thomas, MD](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/2022-stories\/01\/decades-of-leadership-experience\/andy-thomas.jpg) Decades of leadership experience prove vital in the state’s fight against COVID-19 Dr. Andrew Thomas and his decades of leadership experience at The Ohio State University Wexner Medical Center have been vital in the state’s fight against COVID-19.](https:\/\/wexnermedical.osu.edu\/our-stories\/decades-of-leadership-experience-prove-vital)\n\n[![NationalGuard\\_bloglarge](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/2022-stories\/01\/national-guard\/nationalguard_bloglarge.jpg) Ohio National Guard joins frontline staff at The Ohio State University Wexner Medical Center Dozens of other Ohio National Guardsmen have been sent to assist in non-clinical roles, including environmental services, nutrition services and patient transportation. And more are expected in the coming weeks.](https:\/\/wexnermedical.osu.edu\/our-stories\/ohio-national-guard-joins-frontline-staff)\n\n[![HealthDiscoveryLogo](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/healthdiscoverylogo.svg)](https:\/\/health.osu.edu\/)\n\n### Visit [Ohio State Health & Discovery](https:\/\/health.osu.edu\/) for more stories on health, wellness, innovation, research and science news from the experts at Ohio State.\n[Check out health.osu.edu](https:\/\/health.osu.edu\/)\n\n**Subscribe.** Get just the right amount of health and wellness in your inbox.\n\nSubscribe\n\n[![The Ohio State University Wexner Medical Center logo](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/logos\/osuwmclogo-dark.svg?la=en&hash=97FD19BD75A2871BC24312B4DD6F2A71)](https:\/\/wexnermedical.osu.edu\/)\n\n- [Follow us on Facebook](https:\/\/www.facebook.com\/OSUWexnerMedicalCenter)\n- [Follow us on X](https:\/\/twitter.com\/OSUWexMed)\n- [Follow us on Instagram](https:\/\/instagram.com\/osuwexmed\/)\n\n## For Patients\n- [Appointments](https:\/\/wexnermedical.osu.edu\/appointments)\n- [Pay a Bill](https:\/\/wexnermedical.osu.edu\/bill-pay)\n- [MyChart](https:\/\/mychart.osu.edu\/)\n- [Find a Doctor](https:\/\/wexnermedical.osu.edu\/find-a-doctor)\n- [Health Care Services](https:\/\/wexnermedical.osu.edu\/healthcare-services)\n- [Locations](https:\/\/wexnermedical.osu.edu\/locations)\n- [Patient and Visitor Guide](https:\/\/wexnermedical.osu.edu\/patient-and-visitor-guide)\n- [Price Transparency](https:\/\/wexnermedical.osu.edu\/patient-and-visitor-guide\/patient-pricing-lists)\n- [Health and Wellness](https:\/\/wexnermedical.osu.edu\/health-and-wellness)\n- [About Us](https:\/\/wexnermedical.osu.edu\/about-us)\n- [MyHealth](https:\/\/wexnermedical.osu.edu\/features\/myhealth)\n\n## For Providers\n- [Refer a Patient](https:\/\/wexnermedical.osu.edu\/healthcare-professionals\/refer-a-patient)\n- [Ohio State CareLink](https:\/\/wexnermedical.osu.edu\/healthcare-professionals\/ohio-state-carelink)\n- [Departments](https:\/\/wexnermedical.osu.edu\/departments)\n## Helpful Links\n- [Careers](https:\/\/wexnermedical.osu.edu\/careers)\n- [Media Room](https:\/\/wexnermedical.osu.edu\/mediaroom)\n- [Ways To Give](https:\/\/wexnermedical.osu.edu\/ways-to-give)\n- [Quality and Safety](https:\/\/wexnermedical.osu.edu\/about-us\/quality-and-safety)\n- [Contact Us](https:\/\/wexnermedical.osu.edu\/contact-us)\n\n## Related Sites\n- [OSUCCC - James](https:\/\/cancer.osu.edu\/)\n- [College of Medicine](https:\/\/medicine.osu.edu\/)\n- [The Ohio State University](https:\/\/osu.edu\/)\n- [Ohio State Health & Discovery](https:\/\/health.osu.edu\/)\n- [MyChart](https:\/\/mychart.osu.edu\/)\n\n[![Top ranked hospital according to U.S. News & World Report, in 9 specialties for the 2025-2026](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/shared\/components\/badges\/usnwr-badges\/usnewsbadge.png?la=en&hash=54E4C94E8B4205FAF73045BA46890788)](https:\/\/health.usnews.com\/best-hospitals\/area\/oh\/ohio-state-university-wexner-medical-center-6411100)\n\nCopyright © 2026 The Ohio State University Wexner Medical Center\n\n- Review Cookie Settings\n- [Notice of Privacy Practices](https:\/\/wexnermedical.osu.edu\/utility\/footer\/privacy-policy)\n- [Terms of Use](https:\/\/wexnermedical.osu.edu\/utility\/footer\/terms-of-use)\n- [Public Notices](https:\/\/wexnermedical.osu.edu\/utility\/footer\/public-notices)\n- [Disability Access](http:\/\/ada.osu.edu\/)\n- [Vendor Interaction](https:\/\/wexnermedical.osu.edu\/utility\/footer\/vendor-interaction)\n- [Patient Rights](https:\/\/wexnermedical.osu.edu\/utility\/footer\/patient-rights-and-responsibilities)\n- [Notice of Non Discrimination](https:\/\/wexnermedical.osu.edu\/utility\/footer\/notice-of-non-discrimination)\n- [Sitemap](https:\/\/wexnermedical.osu.edu\/utility\/sitemap)\n\nIf you have a disability and experience difficulty accessing this content, contact our webmaster at [webmaster@osumc.edu](mailto:webmaster@osumc.edu).","attrs_readable_markdown":"May 18, 2021\n\n![nosideeffects\\_large](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/2021-stories\/05\/no-side-effects-from-vaccine\/nosideeffects_large.jpg)\n\n***On Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. [Find our most recent COVID-19 blog posts here](https:\/\/wexnermedical.osu.edu\/blog#\/topic\/Coronavirus).***\n\nYou’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working?\n\nThese are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue.\n\n## How does the vaccine work?\nFor the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells.\n\n## Why might there not be a reaction?\nIt’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune\/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not.\n\n## Can medication affect side effects?\nBecause reactions after the vaccine are related to an immune response\/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort.\n\nThe bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all.\n\n*Dr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center.*\n\n[![HealthDiscoveryLogo](https:\/\/wexnermedical.osu.edu\/-\/media\/images\/wexnermedical\/blog\/healthdiscoverylogo.svg)](https:\/\/health.osu.edu\/)\n\n### Visit [Ohio State Health & Discovery](https:\/\/health.osu.edu\/) for more stories on health, wellness, innovation, research and science news from the experts at Ohio State.\n[Check out health.osu.edu](https:\/\/health.osu.edu\/)","meta_canonical":null}

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Meta Title	No reaction to COVID-19 vaccine? No problem – it’s still working \| Ohio State Medical Center
Meta Description	You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working? Learn more from an Ohio State expert.
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Boilerpipe Text	May 18, 2021 On Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. Find our most recent COVID-19 blog posts here . You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working? These are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue. How does the vaccine work? For the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells. Why might there not be a reaction? It’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not. Can medication affect side effects? Because reactions after the vaccine are related to an immune response/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort. The bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all. Dr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center. Visit Ohio State Health & Discovery for more stories on health, wellness, innovation, research and science news from the experts at Ohio State. Check out health.osu.edu
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[Treatments & Services](https://wexnermedical.osu.edu/healthcare-services) ## Featured Services - [Urgent Care](https://wexnermedical.osu.edu/urgent-care) - [Emergency Care](https://wexnermedical.osu.edu/emergency-trauma) - [Telehealth](https://wexnermedical.osu.edu/telehealth) - [Primary Care](https://wexnermedical.osu.edu/primary-care) - [Brain Spine Neuro](https://wexnermedical.osu.edu/brain-spine-neuro) - [Cancer](https://cancer.osu.edu/) - [Heart & Vascular](https://wexnermedical.osu.edu/heart-vascular) - [Laboratory Services](https://wexnermedical.osu.edu/laboratory-services) - [Orthopedics](https://wexnermedical.osu.edu/orthopedics) - [Sports Medicine](https://wexnermedical.osu.edu/orthopedics/sports-medicine) - [Transplant](https://wexnermedical.osu.edu/transplant) - [Second Opinion](https://wexnermedical.osu.edu/second-opinion) - [View All](https://wexnermedical.osu.edu/healthcare-services) ## Popular Services - [Aesthetics](https://wexnermedical.osu.edu/aesthetics) - [Allergy Immunology Care](https://wexnermedical.osu.edu/ear-nose-throat/allergy-immunology-care) - [Arthritis Rheumatology](https://wexnermedical.osu.edu/arthritis-rheumatology) - [Asthma Care](https://wexnermedical.osu.edu/asthma-care) - [Bariatric Surgery](https://wexnermedical.osu.edu/weight-management/bariatric-surgery) - [Burn Care](https://wexnermedical.osu.edu/burn-care) - [Diabetes & Endocrinology](https://wexnermedical.osu.edu/diabetes-endocrinology) - [Digestive Diseases](https://wexnermedical.osu.edu/digestive-diseases) - [Ear Nose Throat](https://wexnermedical.osu.edu/ear-nose-throat) - [Eye Care Ophthalmology](https://wexnermedical.osu.edu/eye-care-ophthalmology) - [Gender-Affirming Care](https://wexnermedical.osu.edu/gender-affirming-care) - [Genetics](https://wexnermedical.osu.edu/genetics) - [Geriatrics](https://wexnermedical.osu.edu/geriatrics) - [Health & Fitness](https://wexnermedical.osu.edu/health-and-fitness) - [Health & Wellness](https://wexnermedical.osu.edu/health-and-wellness) - [Health Screenings](https://wexnermedical.osu.edu/routine-care) - [Imaging](https://wexnermedical.osu.edu/imaging) - [Infectious Diseases](https://wexnermedical.osu.edu/infectious-diseases) - [Integrative Health](https://wexnermedical.osu.edu/integrative-health) - [Intensive Care](https://wexnermedical.osu.edu/intensive-care) - [Kidney Care](https://wexnermedical.osu.edu/kidney-care) - [Liver Diseases](https://wexnermedical.osu.edu/liver-diseases) - [Lung Pulmonary](https://wexnermedical.osu.edu/lung-pulmonary) - [Maternity Center](https://wexnermedical.osu.edu/obstetrics-gynecology/pregnancy/maternity-center) - [Mental Behavioral](https://wexnermedical.osu.edu/mental-behavioral) - [Neurological Institute](https://wexnermedical.osu.edu/neurological-institute) - [Nutrition Services](https://wexnermedical.osu.edu/nutrition-services) - [Obstetrics & Gynecology](https://wexnermedical.osu.edu/obstetrics-gynecology) - [Palliative Care](https://wexnermedical.osu.edu/palliative-care) - [Pancreas Care](https://wexnermedical.osu.edu/pancreas-care) - [Pharmacy](https://wexnermedical.osu.edu/pharmacy) - [Physical Therapy & Rehabilitation](https://wexnermedical.osu.edu/physical-therapy-rehabilitation) - [Plastic Surgery](https://wexnermedical.osu.edu/plastic-surgery) - [Skin Care Dermatology](https://wexnermedical.osu.edu/skin-care-dermatology) - [Sleep Disorders](https://wexnermedical.osu.edu/sleep-disorders) - [Substance Use Disorder](https://wexnermedical.osu.edu/mental-behavioral/substance-use-disorder-addiction-treatment) - [Urology](https://wexnermedical.osu.edu/urology) - [Weight Management](https://wexnermedical.osu.edu/weight-management) - [Wound Healing](https://wexnermedical.osu.edu/wound-healing) - [View All](https://wexnermedical.osu.edu/healthcare-services) - [Locations](https://wexnermedical.osu.edu/locations) - [Patient & Visitor Guide](https://wexnermedical.osu.edu/patient-and-visitor-guide) - [Health Equity](https://wexnermedical.osu.edu/health-equity) Expand Health Equity ## Committed to improving health and wellness in our Ohio communities. [Health Equity](https://wexnermedical.osu.edu/health-equity) ## Health Equity - [Strategic Approach](https://wexnermedical.osu.edu/health-equity/our-strategic-approach) - [Team and Advisory Board](https://wexnermedical.osu.edu/health-equity/team-and-advisory-board) ## Community Programs - [Urban Health](https://wexnermedical.osu.edu/health-equity/urban-health) - [Rural and State Health](https://wexnermedical.osu.edu/health-equity/rural-and-state-health) - [National and Global Health](https://wexnermedical.osu.edu/health-equity/national-and-global-health) - [Mental and Behavioral Health and Substance Use Disorder](https://wexnermedical.osu.edu/health-equity/mental-and-behavioral-health-and-substance-use-disorder) - [Maternal and Infant Health](https://wexnermedical.osu.edu/health-equity/maternal-and-infant-health) - [Access to Care](https://wexnermedical.osu.edu/health-equity/access-to-care) - [Nutrition and Food Security](https://wexnermedical.osu.edu/health-equity/nutrition-and-food-security) - [Digital Health Equity](https://wexnermedical.osu.edu/health-equity/digital-health-equity) - [Healthy Community Center](https://wexnermedical.osu.edu/health-equity/healthy-community-center) ## Classes and Events - [Weight Management Classes](https://wexnermedical.osu.edu/weight-management) - [About Us](https://wexnermedical.osu.edu/about-us) Expand About Us ## The world is changing. Medicine is changing. We're leading the way. [About Us](https://wexnermedical.osu.edu/about-us) ## Who We Are - [Why Choose Us](https://wexnermedical.osu.edu/about-us/why-choose-ohio-state) - [Our Mission](https://wexnermedical.osu.edu/about-us/our-mission) - [Our People](https://wexnermedical.osu.edu/about-us/our-people) - [Our Stories](https://wexnermedical.osu.edu/our-stories-redirect) - [Our Facilities](https://wexnermedical.osu.edu/about-us/our-facilities) - [Quality and Safety](https://wexnermedical.osu.edu/about-us/quality-and-safety) - [Rankings and Awards](https://wexnermedical.osu.edu/about-us/rankings-and-awards) - [Sustainability](https://wexnermedical.osu.edu/about-us/sustainability) ## Featured Initiatives - [Strategic Plan](https://wexnermedical.osu.edu/about-us/strategic-plan) - [U.S. News & World Report](https://wexnermedical.osu.edu/about-us/us-news) - [Healthy State Alliance](https://wexnermedical.osu.edu/health-equity/healthy-state-alliance) ## Helpful Resources - [Mobile Apps](https://wexnermedical.osu.edu/features/myhealth) - [Social Media](https://wexnermedical.osu.edu/about-us/social-media) - [Patient Experience](https://wexnermedical.osu.edu/about-us/quality-and-safety) - [Vendor Interactions](https://wexnermedical.osu.edu/utility/footer/vendor-interaction) - [Contact Us](https://wexnermedical.osu.edu/contact-us) - [Refer a Patient](https://wexnermedical.osu.edu/healthcare-professionals/refer-a-patient) Open Search # No reaction to COVID-19 vaccine? No problem – it’s still working Author: [Ashley Lipps, MD](https://wexnermedical.osu.edu/our-stories/#/author/Ashley%20Lipps,%20MD) Topics: - [Health and Wellness](https://wexnermedical.osu.edu/our-stories/#/topic/Health%20and%20Wellness) - [Coronavirus](https://wexnermedical.osu.edu/our-stories/#/topic/Coronavirus) May 18, 2021 ![nosideeffects\_large](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/2021-stories/05/no-side-effects-from-vaccine/nosideeffects_large.jpg) *On Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. [Find our most recent COVID-19 blog posts here](https://wexnermedical.osu.edu/blog#/topic/Coronavirus).* You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working? These are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue. ## How does the vaccine work? For the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells. ## Why might there not be a reaction? It’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not. ## Can medication affect side effects? Because reactions after the vaccine are related to an immune response/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort. The bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all. Dr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center. - [Ready to get vaccinated? We have appointments available as early as today.Get vaccinated](https://wexnermedical.osu.edu/infectious-diseases/covid-19/schedule-your-vaccine) ## More from Ohio State [![U.S. Sen. Sherrod Brown standing with members from the Ohio National Guard and the Ohio State Wexner Medical Center](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/2022-stories/01/sen-brown/sen_brown.jpg) Sen. Brown tours COVID-19 testing site at CAS Sen. Brown talks with members of the Ohio National Guard who’ve joined health care workers across the state on the front lines in the battle against COVID-19.](https://wexnermedical.osu.edu/our-stories/sen-brown-tours-covid-19-testing-site-at-cas) [![Andrew Thomas, MD](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/2022-stories/01/decades-of-leadership-experience/andy-thomas.jpg) Decades of leadership experience prove vital in the state’s fight against COVID-19 Dr. Andrew Thomas and his decades of leadership experience at The Ohio State University Wexner Medical Center have been vital in the state’s fight against COVID-19.](https://wexnermedical.osu.edu/our-stories/decades-of-leadership-experience-prove-vital) [![NationalGuard\_bloglarge](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/2022-stories/01/national-guard/nationalguard_bloglarge.jpg) Ohio National Guard joins frontline staff at The Ohio State University Wexner Medical Center Dozens of other Ohio National Guardsmen have been sent to assist in non-clinical roles, including environmental services, nutrition services and patient transportation. 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Readable Markdown	May 18, 2021 ![nosideeffects\_large](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/2021-stories/05/no-side-effects-from-vaccine/nosideeffects_large.jpg) *On Aug. 23, 2021, the U.S. Food and Drug Administration approved the Pfizer COVID-19 vaccine for the prevention of COVID-19 disease in people 16 and older. This story has been updated to reflect that approval. As what we know about COVID-19 evolves, so could the information contained in this story. [Find our most recent COVID-19 blog posts here](https://wexnermedical.osu.edu/blog#/topic/Coronavirus).* You’ve heard about the side effects from getting the COVID-19 vaccine. But after you got your shot, you didn’t have a reaction – nothing at all. Should you be concerned? Is the vaccine working? These are questions some patients have asked me after getting their shot. Fortunately, there’s no reason to be worried. Just because you didn’t have a reaction – or not much of one – doesn’t mean your body isn’t mounting a response to the vaccine. The reality is that not everyone has a reaction. As a matter of fact, studies show only about 50% of patients experience side effects. The most common ones are sore arms, fever, chills and fatigue. ## How does the vaccine work? For the Pfizer and Moderna vaccines, mRNA (or messenger RNA) is injected, sending specific instructions for your body to create a piece of the SARS-CoV-2 virus, the virus that causes COVID-19, called the spike protein. Once the spike protein is created, your body’s immune system recognizes this protein as a “foreign invader” and starts to attack. This is when your immune system is stimulated and antibodies produced. But you don’t actually get sick because your body is only exposed to a small portion of the virus and not the intact virus that can cause the disease. The antibodies against the spike protein remain in your body and are available and ready to protect you if you’re exposed to the SARS-CoV-2 virus. With the Johnson and Johnson vaccine, the instructions for making the spike protein are delivered to your cells in the form of DNA (as opposed to mRNA). A type of weakened cold virus (called an adenovirus vector) transports the DNA into your cells. ## Why might there not be a reaction? It’s not entirely clear why some people experience side effects and others don’t. It’s likely related to variations in the immune system and its response, which may be influenced by things like age, genetics or underlying medical conditions. We’re also seeing that women and younger people are more likely to experience reactions after the vaccine. This may be because they tend to mount a more robust immune/inflammatory response but the reasons for this aren’t clear. The immune system is very complex, making it hard to pinpoint exactly what makes someone react or not. ## Can medication affect side effects? Because reactions after the vaccine are related to an immune response/inflammation, there’s concern that taking anti-inflammatory medications (such as ibuprofen) can disrupt the body's natural response to the vaccine. The U.S. Centers for Disease Control and Prevention recommends against taking these anti-inflammatory medications pre-emptively before vaccination. However, it’s OK to use them after the shot if you’re experiencing discomfort. The bottom line is not to worry if you had a strong reaction or not. Studies show a high level of protection for everyone vaccinated – whether there was a strong reaction or none at all. Dr. Ashley Lipps is an infectious diseases physician and assistant professor in the Division of Infectious Diseases at The Ohio State University Wexner Medical Center. [![HealthDiscoveryLogo](https://wexnermedical.osu.edu/-/media/images/wexnermedical/blog/healthdiscoverylogo.svg)](https://health.osu.edu/) ### Visit [Ohio State Health & Discovery](https://health.osu.edu/) for more stories on health, wellness, innovation, research and science news from the experts at Ohio State. [Check out health.osu.edu](https://health.osu.edu/)
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