🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 45 (from laksa005)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa045.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://twin-cities.umn.edu/news-events/study-uncovers-basis-covid-19-related-brain-fog\')), getAhrefsUnparsedNoserviceFromURL(\'https://twin-cities.umn.edu/news-events/study-uncovers-basis-covid-19-related-brain-fog\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/twin-cities.umn.edu\/news-events\/study-uncovers-basis-covid-19-related-brain-fog","crawl_time":1760925964,"first_indexed_time":1724191531,"http_code":200,"src_unparsed":"edu,umn!twin-cities,\/news-events\/study-uncovers-basis-covid-19-related-brain-fog s443","src_root_hash":"1624480930799954845","history_drop_reason":null,"meta_title":"Study uncovers the basis of COVID-19-related brain fog | University of Minnesota","meta_descriptions":["Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.”"],"attrs_boilerpipe_text":"Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.”  Published in  Frontiers in Microbiology , the researchers examined the specific ways the virus impacts the brain, developing a preclinical model to accurately mimic the effects of COVID-19 on humans to explore the impact of age and sex on the brain-related impacts of the disease.  The study was led by Maxim Cheeran in the College of Veterinary Medicine, Ling Li in the College of Pharmacy and Walter Low in the Medical School. The findings include: SARS-CoV-2 infection triggered a neuroinflammatory response, despite the lack of detectable virus in the brain.  Older age males showed a higher viral load and more pronounced symptoms.  Older age also led to increased neurological inflammation.  The researchers also found several biological pathways that the virus impacts in the brain, including overactive or misdirected immune response, disruption to the protective blood-brain barrier, damage to cells lining blood vessels, and impacts to how nerve cells are formed and function. These impacts can impair brain function and may even lead to permanent damage. “There are still things we don’t know about how coronavirus infection affects the brain, and our research is beginning to unravel the mystery,” said Cheeran. “We now know that viral infection in the lungs can cause inflammatory changes in the brain, affected by the age and sex of the patient. With this model, we can further examine the connections between the infected lung and the brain, and start development on targeted treatments to mitigate the impact of COVID-19 on the brain.” In addition to new targeted therapies, these findings allow for more accurate vaccine development and continued research. The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss. This work was supported in part by grants from the National Institutes of Health\/National Institute on Aging and the SURRGE award program of the University of Minnesota’s College of Pharmacy. -30- About the College of Veterinary Medicine The University of Minnesota College of Veterinary Medicine affects the lives of animals and people every day through educational, research, service, and outreach programs. Established in 1947, the University of Minnesota College of Veterinary Medicine is Minnesota’s only veterinary college. Fully accredited, the college has graduated over 4,000 veterinarians and hundreds of scientists. The college is also home to the Veterinary Medical Center, the Veterinary Diagnostic Laboratory, the Leatherdale Equine Center and The Raptor Center. Learn more at vetmed.umn.edu. About the College of Pharmacy Founded in 1892, the University of Minnesota College of Pharmacy is the only pharmacy school in Minnesota, with campuses in the Twin Cities and in Duluth. The College of Pharmacy improves health through innovative education, pioneering research and interdisciplinary practice development that attends to the diverse needs of the people of Minnesota and the world. Learn more at pharmacy.umn.edu. About the Medical School The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. Learn more at med.umn.edu.","attrs_markdown":"![](https:\/\/www.facebook.com\/tr?id=399614574009910&ev=PageView&noscript=1)  [Skip to main content](https:\/\/twin-cities.umn.edu\/news-events\/study-uncovers-basis-covid-19-related-brain-fog#main-content)\n\n[Wordmark of the University of Minnesota Twin Cities](https:\/\/twin-cities.umn.edu\/ \"Wordmark of the University of Minnesota Twin Cities\")\n\n[News and Events](https:\/\/twin-cities.umn.edu\/news-events\/)\n\n## Utility Menu\n- [MyU](https:\/\/myu.umn.edu\/ \"MyU\")\n- [One Stop](https:\/\/onestop.umn.edu\/)\n- [Jobs](https:\/\/humanresources.umn.edu\/content\/find-job)\n- [Give](https:\/\/give.umn.edu\/giveto\/mission)\n\n- Search\n- Menu\n\n- Search\n- Menu\n\nClose search area\n\n## Common Search Terms\n- [Housing](https:\/\/housing.umn.edu\/)\n- [Libraries](https:\/\/lib.umn.edu\/)\n- [Bookstore](https:\/\/bookstores.umn.edu\/)\n- [Tuition Cost](https:\/\/admissions.tc.umn.edu\/costsaid\/index.html)\n- [Academic Calendar](https:\/\/onestop.umn.edu\/dates-and-deadlines)\n\n## News Section Menu\n- [Topics](https:\/\/twin-cities.umn.edu\/news-events)\n- [All News](https:\/\/twin-cities.umn.edu\/news-events\/all-news)\n- [For Journalists](https:\/\/twin-cities.umn.edu\/news-events\/for-journalists)\n- [Events](https:\/\/events.tc.umn.edu\/)\n\n## Task List\n- [MyU](https:\/\/myu.umn.edu\/)\n- [One Stop](https:\/\/onestop.umn.edu\/)\n- [Jobs](https:\/\/humanresources.umn.edu\/content\/find-job)\n- [Give](https:\/\/give.umn.edu\/giveto\/mission)\n\n- [Topics](https:\/\/twin-cities.umn.edu\/news-events)\n  - [Agriculture & Environment](https:\/\/twin-cities.umn.edu\/news-events\/topic\/agriculture-environment)\n  - [Architecture & Design](https:\/\/twin-cities.umn.edu\/news-events\/topic\/architecture-design)\n  - [Arts & Humanities](https:\/\/twin-cities.umn.edu\/news-events\/topic\/arts-humanities)\n  - [Business & Management](https:\/\/twin-cities.umn.edu\/news-events\/topic\/business-management)\n  - [Campus Affairs](https:\/\/twin-cities.umn.edu\/news-events\/topic\/campus-affairs)\n  - [Education](https:\/\/twin-cities.umn.edu\/news-events\/topic\/education)\n  - [Health](https:\/\/twin-cities.umn.edu\/news-events\/topic\/health)\n  - [Law & Policy](https:\/\/twin-cities.umn.edu\/news-events\/topic\/law-policy)\n  - [Science & Technology](https:\/\/twin-cities.umn.edu\/news-events\/topic\/science-technology)\n  - [Social Sciences](https:\/\/twin-cities.umn.edu\/news-events\/topic\/social-sciences)\n  - [Sports & Recreation](https:\/\/twin-cities.umn.edu\/news-events\/topic\/sports-recreation)\n- [All News](https:\/\/twin-cities.umn.edu\/news-events\/all-news)\n- [For Journalists](https:\/\/twin-cities.umn.edu\/news-events\/for-journalists)\n- [Events](https:\/\/events.tc.umn.edu\/)\n\n## Breadcrumb\n1. [Home](https:\/\/twin-cities.umn.edu\/)\n2. [News & Events](https:\/\/twin-cities.umn.edu\/news-events)\n3. Study uncovers the basis of COVID-19-related brain fog\n\n[Research Brief](https:\/\/twin-cities.umn.edu\/news-events\/story-archive?type=731)\n\n# Study uncovers the basis of COVID-19-related brain fog\nAugust 19, 2024\n\n![Microscopic view of the virus that causes COVID-19.\" Image size: 900x600 for web; 75% scale in email](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/Unews%20Image%20Templates%203_2%20%281%29.jpg)\n\nNew U of M research examines the specific ways SARS-CoV-2 impacts the brain. Credit: University of Minnesota\n\nNeurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.”   \n  \nPublished in [Frontiers in Microbiology](https:\/\/www.frontiersin.org\/journals\/microbiology\/articles\/10.3389\/fmicb.2024.1404312\/full?utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field&journalName=Frontiers_in_Microbiology&id=1404312), the researchers examined the specific ways the virus impacts the brain, developing a preclinical model to accurately mimic the effects of COVID-19 on humans to explore the impact of age and sex on the brain-related impacts of the disease.\n\nThe study was led by Maxim Cheeran in the College of Veterinary Medicine, Ling Li in the College of Pharmacy and Walter Low in the Medical School. The findings include:\n\n- SARS-CoV-2 infection triggered a neuroinflammatory response, despite the lack of detectable virus in the brain.\n- Older age males showed a higher viral load and more pronounced symptoms.\n- Older age also led to increased neurological inflammation.\n\nThe researchers also found several biological pathways that the virus impacts in the brain, including overactive or misdirected immune response, disruption to the protective blood-brain barrier, damage to cells lining blood vessels, and impacts to how nerve cells are formed and function. These impacts can impair brain function and may even lead to permanent damage.\n\n“There are still things we don’t know about how coronavirus infection affects the brain, and our research is beginning to unravel the mystery,” said Cheeran. “We now know that viral infection in the lungs can cause inflammatory changes in the brain, affected by the age and sex of the patient. With this model, we can further examine the connections between the infected lung and the brain, and start development on targeted treatments to mitigate the impact of COVID-19 on the brain.”\n\nIn addition to new targeted therapies, these findings allow for more accurate vaccine development and continued research. The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss.\n\nThis work was supported in part by grants from the National Institutes of Health\/National Institute on Aging and the SURRGE award program of the University of Minnesota’s College of Pharmacy.\n\n\\-30-\n\n**About the College of Veterinary Medicine** The University of Minnesota College of Veterinary Medicine affects the lives of animals and people every day through educational, research, service, and outreach programs. Established in 1947, the University of Minnesota College of Veterinary Medicine is Minnesota’s only veterinary college. Fully accredited, the college has graduated over 4,000 veterinarians and hundreds of scientists. The college is also home to the Veterinary Medical Center, the Veterinary Diagnostic Laboratory, the Leatherdale Equine Center and The Raptor Center. Learn more at vetmed.umn.edu.  \n **About the College of Pharmacy** Founded in 1892, the University of Minnesota College of Pharmacy is the only pharmacy school in Minnesota, with campuses in the Twin Cities and in Duluth. The College of Pharmacy improves health through innovative education, pioneering research and interdisciplinary practice development that attends to the diverse needs of the people of Minnesota and the world. Learn more at pharmacy.umn.edu.\n\n**About the Medical School**  \nThe University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. Learn more at med.umn.edu.\n\n- Categories:\n- [Health](https:\/\/twin-cities.umn.edu\/news-events\/topic\/health)\n- [COVID-19](https:\/\/twin-cities.umn.edu\/news-events\/topic\/covid-19)\n\nShare this story\n\n- [Link to share current story on Twitter](https:\/\/twitter.com\/intent\/tweet?text=%26nbsp%3BNeurological%20symptoms%20have%20been%20widely%20observed%20in%20COVID-19%20patients%2C%20with%20many%20survivors%20exhibiting%20persistent%20neurological%20and%20cognitive%20impairment.%20New%20research%20from%20the%20University%20of%20Minnesota%20found%20that%20COVID-19%20triggers%20inflammation%20in%20the%20brain%2C%20which%20is%20linked%20to%20many%20COVID-related%20symptoms%20such%20as%20fatigue%20and%20%E2%80%9Cbrain%20fog.%E2%80%9D%20https%3A%2F%2Ftwin-cities.umn.edu%2Fnews-events%2Fstudy-uncovers-basis-covid-19-related-brain-fog)\n- [Link to share current story on Facebook](https:\/\/www.facebook.com\/sharer\/sharer.php?u=https:\/\/twin-cities.umn.edu\/news-events\/study-uncovers-basis-covid-19-related-brain-fog)\n- [Link to share current story via email](mailto:?subject=Study%20uncovers%20the%20basis%20of%20COVID-19-related%20brain%20fog&body=%26nbsp%3BNeurological%20symptoms%20have%20been%20widely%20observed%20in%20COVID-19%20patients%2C%20with%20many%20survivors%20exhibiting%20persistent%20neurological%20and%20cognitive%20impairment.%20New%20research%20from%20the%20University%20of%20Minnesota%20found%20that%20COVID-19%20triggers%20inflammation%20in%20the%20brain%2C%20which%20is%20linked%20to%20many%20COVID-related%20symptoms%20such%20as%20fatigue%20and%20%E2%80%9Cbrain%20fog.%E2%80%9D%0Ahttps:\/\/twin-cities.umn.edu\/news-events\/study-uncovers-basis-covid-19-related-brain-fog)\n\n## Media Contacts\n### Rachel Cain\nUniversity Public Relations\n\n[rcain@umn.edu](mailto:rcain@umn.edu)\n\n## More stories in [Health](https:\/\/twin-cities.umn.edu\/news-events\/topic\/health)\n[![A young woman doing a breast ultrasound for preventive breast cancer care.](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/styles\/crop_to_333px\/public\/Breast%20cancer%20900x600.jpg?itok=He85Zb1g)](https:\/\/twin-cities.umn.edu\/news-events\/talking-breast-cancer-university-minnesota)\n\nTalking with University of Minnesota\n\n### [Talking breast cancer with University of Minnesota](https:\/\/twin-cities.umn.edu\/news-events\/talking-breast-cancer-university-minnesota)\nDr. Stuart Bloom discusses breast cancer for Breast Cancer Awareness Month in October.\n\n[![Headshot images of Ann Marcelle Lewandowski and Peter Calow](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/styles\/crop_to_333px\/public\/Unews%20Image%20Templates%203_2_14.jpg?itok=Sd3D21-R)](https:\/\/twin-cities.umn.edu\/news-events\/talking-safe-drinking-water-university-minnesota)\n\nTalking with University of Minnesota\n\n### [Talking safe drinking water with University of Minnesota](https:\/\/twin-cities.umn.edu\/news-events\/talking-safe-drinking-water-university-minnesota)\nDrinking water is one of the most important factors in our day-to-day health. Yet, many Minnesotans rarely think about it, thanks to our abundant water supplies, strong protections and well-coordinated network of water professionals at the state and local levels.\n\n## Editor's picks\n[![Karen Guise with a fruit in a Hawaiian forest](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/styles\/crop_to_333px\/public\/karen-guise.jpg?itok=XJ7bw8Wl)](https:\/\/twin-cities.umn.edu\/news-events\/student-taps-unique-perspectives-through-immersive-study-away-program)\n\nFeature\n\n### [Student taps into unique perspectives through immersive study-away program](https:\/\/twin-cities.umn.edu\/news-events\/student-taps-unique-perspectives-through-immersive-study-away-program)\nPolitical science student Karen Guise studied at the University of Hawai'i at Hilo for a semester through National Student Exchange.\n\nFeature\n\n### [His students’ writings reach a global audience](https:\/\/twin-cities.umn.edu\/news-events\/his-students-writings-reach-global-audience)\nJim Cotner’s biology students fortify Wikipedia articles with durable evidence-based science writing.\n\n[![Minnesota Carlson graduate Sakthika Vijay poses with her arms crossed inside of a hallway.](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/styles\/crop_to_333px\/public\/sakthika-900x600.png?itok=lGIA4kGH)](https:\/\/twin-cities.umn.edu\/news-events\/how-minnesota-carlson-shaped-young-adult-fiction-author)\n\nFeature\n\n### [How Minnesota Carlson shaped a young-adult fiction author](https:\/\/twin-cities.umn.edu\/news-events\/how-minnesota-carlson-shaped-young-adult-fiction-author)\nRecent graduate Sakthika Vijay released her second book earlier this month, and her Minnesota Carlson degree helped her get there.\n\n[![Zayna Amanat](https:\/\/twin-cities.umn.edu\/sites\/twin-cities.umn.edu\/files\/styles\/crop_to_333px\/public\/zayna-amanat-netflix-intern.jpg?itok=Kvt-anNX)](https:\/\/twin-cities.umn.edu\/news-events\/behind-screens-insights-netflix-internship)\n\nFeature\n\n### [Behind the screens: Insights from a Netflix internship](https:\/\/twin-cities.umn.edu\/news-events\/behind-screens-insights-netflix-internship)\nA blockbuster internship with Netflix helped recent graduate Zayna Amanat put her education to work.\n\n[See all stories](https:\/\/twin-cities.umn.edu\/news-events\/story-archive)\n\n[UMN Crookston](https:\/\/crk.umn.edu\/ \"University of Minnesota Crookston\")\n\n[UMN Morris](https:\/\/www4.morris.umn.edu\/ \"University of Minnesota Morris\")\n\n[UMN Duluth](https:\/\/d.umn.edu\/ \"University of Minnesota Duluth\")\n\n[UMN Twin Cities](https:\/\/twin-cities.umn.edu\/ \"University of Minnesota Twin Cities\")\n\n[UMN Rochester](https:\/\/r.umn.edu\/ \"University of Minnesota Rochester\")\n\n## Campuses\n- [System Website](https:\/\/system.umn.edu\/)\n- [Crookston](https:\/\/www.crk.umn.edu\/)\n- [Duluth](https:\/\/www.d.umn.edu\/)\n- [Morris](https:\/\/morris.umn.edu\/)\n- [Rochester](https:\/\/r.umn.edu\/)\n- [Twin Cities](https:\/\/twin-cities.umn.edu\/)\n\n## For Journalists\n- [Find an Expert](https:\/\/twin-cities.umn.edu\/news-events\/expert-search)\n- [For Journalists](https:\/\/twin-cities.umn.edu\/news-events\/for-journalists)\n- [Guidelines for Journalists](https:\/\/twin-cities.umn.edu\/news-events\/guidelines-journalists)\n- [Meet the PR Team](https:\/\/twin-cities.umn.edu\/news-events\/meet-twin-cities-public-relations-team)\n\n## Contact\n[unews@umn.edu](mailto:unews@umn.edu) [612-624-5551](tel:612-624-5551)\n\nHealthier.   \nHere, There, and Everywhere.\n\n[Healthier Campaign](https:\/\/system.umn.edu\/healthier)\n\n## Connect with us\n- [Link to U of M's Facebook page](https:\/\/www.facebook.com\/UofMN)\n- [Link to U of M's Instagram page](https:\/\/www.instagram.com\/umntwincities)\n- [Link to U of M's LinkedIn page](https:\/\/www.linkedin.com\/company\/university-of-minnesota)\n- [Link to U of M's Tiktok account](https:\/\/www.tiktok.com\/@umntwincities)\n- [Link to U of M's Twitter page](https:\/\/twitter.com\/umnews)\n- [Link to U of M's Youtube page](https:\/\/www.youtube.com\/user\/UniversityofMinn)\n- [Link to U of M's Threads Account](https:\/\/www.threads.net\/@umntwincities)\n\n[Wordmark of the University of Minnesota Twin Cities](https:\/\/twin-cities.umn.edu\/ \"Wordmark of the University of Minnesota Twin Cities\")\n\n- [Crookston](https:\/\/www.crk.umn.edu\/)\n- [Duluth](https:\/\/www.d.umn.edu\/)\n- [Morris](https:\/\/morris.umn.edu\/)\n- [Rochester](https:\/\/r.umn.edu\/)\n- [Twin Cities](https:\/\/twin-cities.umn.edu\/)\n\n© 2025 Regents of the University of Minnesota. All rights reserved.  \n The University of Minnesota is an equal opportunity educator and employer.\n\n[Privacy Statement](https:\/\/twin-cities.umn.edu\/node\/25811) \\| [Report Digital Accessibility Issue](https:\/\/z.umn.edu\/report-accessibility-issue)\n\n[Website Feedback](https:\/\/umn.qualtrics.com\/SE\/?SID=SV_6fGtBWZDtU4LHxj&page=study-uncovers-the-basis-of-covid-19-related-brain-fog)","attrs_readable_markdown":null,"meta_canonical":null}

3. Robots.txt Check

Query:

Response:

4. Spam/Ban Check

Query:

Response:

5. Seen Status Check

ℹ️ Skipped - page is already crawled

📄

INDEXABLE

✅

CRAWLED

5 months ago

🤖

ROBOTS ALLOWED

Page Info Filters

Filter	Status	Condition	Details
HTTP status	PASS	`download_http_code = 200`	HTTP 200
Age cutoff	PASS	`download_stamp > now() - 6 MONTH`	5.9 months ago
History drop	PASS	`isNull(history_drop_reason)`	No drop reason
Spam/ban	PASS	`fh_dont_index != 1 AND ml_spam_score = 0`	ml_spam_score=0
Canonical	PASS	`meta_canonical IS NULL OR = '' OR = src_unparsed`	Not set

Page Details

Property	Value
URL	https://twin-cities.umn.edu/news-events/study-uncovers-basis-covid-19-related-brain-fog
Last Crawled	2025-10-20 02:06:04 (5 months ago)
First Indexed	2024-08-20 22:05:31 (1 year ago)
HTTP Status Code	200
Meta Title	Study uncovers the basis of COVID-19-related brain fog \| University of Minnesota
Meta Description	Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.”
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Boilerpipe Text	Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.” Published in Frontiers in Microbiology , the researchers examined the specific ways the virus impacts the brain, developing a preclinical model to accurately mimic the effects of COVID-19 on humans to explore the impact of age and sex on the brain-related impacts of the disease. The study was led by Maxim Cheeran in the College of Veterinary Medicine, Ling Li in the College of Pharmacy and Walter Low in the Medical School. The findings include: SARS-CoV-2 infection triggered a neuroinflammatory response, despite the lack of detectable virus in the brain. Older age males showed a higher viral load and more pronounced symptoms. Older age also led to increased neurological inflammation. The researchers also found several biological pathways that the virus impacts in the brain, including overactive or misdirected immune response, disruption to the protective blood-brain barrier, damage to cells lining blood vessels, and impacts to how nerve cells are formed and function. These impacts can impair brain function and may even lead to permanent damage. “There are still things we don’t know about how coronavirus infection affects the brain, and our research is beginning to unravel the mystery,” said Cheeran. “We now know that viral infection in the lungs can cause inflammatory changes in the brain, affected by the age and sex of the patient. With this model, we can further examine the connections between the infected lung and the brain, and start development on targeted treatments to mitigate the impact of COVID-19 on the brain.” In addition to new targeted therapies, these findings allow for more accurate vaccine development and continued research. The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss. This work was supported in part by grants from the National Institutes of Health/National Institute on Aging and the SURRGE award program of the University of Minnesota’s College of Pharmacy. -30- About the College of Veterinary Medicine The University of Minnesota College of Veterinary Medicine affects the lives of animals and people every day through educational, research, service, and outreach programs. Established in 1947, the University of Minnesota College of Veterinary Medicine is Minnesota’s only veterinary college. Fully accredited, the college has graduated over 4,000 veterinarians and hundreds of scientists. The college is also home to the Veterinary Medical Center, the Veterinary Diagnostic Laboratory, the Leatherdale Equine Center and The Raptor Center. Learn more at vetmed.umn.edu. About the College of Pharmacy Founded in 1892, the University of Minnesota College of Pharmacy is the only pharmacy school in Minnesota, with campuses in the Twin Cities and in Duluth. The College of Pharmacy improves health through innovative education, pioneering research and interdisciplinary practice development that attends to the diverse needs of the people of Minnesota and the world. Learn more at pharmacy.umn.edu. About the Medical School The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. Learn more at med.umn.edu.
Markdown	![](https://www.facebook.com/tr?id=399614574009910&ev=PageView&noscript=1) [Skip to main content](https://twin-cities.umn.edu/news-events/study-uncovers-basis-covid-19-related-brain-fog#main-content) [Wordmark of the University of Minnesota Twin Cities](https://twin-cities.umn.edu/ "Wordmark of the University of Minnesota Twin Cities") [News and Events](https://twin-cities.umn.edu/news-events/) ## Utility Menu - [MyU](https://myu.umn.edu/ "MyU") - [One Stop](https://onestop.umn.edu/) - [Jobs](https://humanresources.umn.edu/content/find-job) - [Give](https://give.umn.edu/giveto/mission) - Search - Menu - Search - Menu Close search area ## Common Search Terms - [Housing](https://housing.umn.edu/) - [Libraries](https://lib.umn.edu/) - [Bookstore](https://bookstores.umn.edu/) - [Tuition Cost](https://admissions.tc.umn.edu/costsaid/index.html) - [Academic Calendar](https://onestop.umn.edu/dates-and-deadlines) ## News Section Menu - [Topics](https://twin-cities.umn.edu/news-events) - [All News](https://twin-cities.umn.edu/news-events/all-news) - [For Journalists](https://twin-cities.umn.edu/news-events/for-journalists) - [Events](https://events.tc.umn.edu/) ## Task List - [MyU](https://myu.umn.edu/) - [One Stop](https://onestop.umn.edu/) - [Jobs](https://humanresources.umn.edu/content/find-job) - [Give](https://give.umn.edu/giveto/mission) - [Topics](https://twin-cities.umn.edu/news-events) - [Agriculture & Environment](https://twin-cities.umn.edu/news-events/topic/agriculture-environment) - [Architecture & Design](https://twin-cities.umn.edu/news-events/topic/architecture-design) - [Arts & Humanities](https://twin-cities.umn.edu/news-events/topic/arts-humanities) - [Business & Management](https://twin-cities.umn.edu/news-events/topic/business-management) - [Campus Affairs](https://twin-cities.umn.edu/news-events/topic/campus-affairs) - [Education](https://twin-cities.umn.edu/news-events/topic/education) - [Health](https://twin-cities.umn.edu/news-events/topic/health) - [Law & Policy](https://twin-cities.umn.edu/news-events/topic/law-policy) - [Science & Technology](https://twin-cities.umn.edu/news-events/topic/science-technology) - [Social Sciences](https://twin-cities.umn.edu/news-events/topic/social-sciences) - [Sports & Recreation](https://twin-cities.umn.edu/news-events/topic/sports-recreation) - [All News](https://twin-cities.umn.edu/news-events/all-news) - [For Journalists](https://twin-cities.umn.edu/news-events/for-journalists) - [Events](https://events.tc.umn.edu/) ## Breadcrumb 1. [Home](https://twin-cities.umn.edu/) 2. [News & Events](https://twin-cities.umn.edu/news-events) 3. Study uncovers the basis of COVID-19-related brain fog [Research Brief](https://twin-cities.umn.edu/news-events/story-archive?type=731) # Study uncovers the basis of COVID-19-related brain fog August 19, 2024 ![Microscopic view of the virus that causes COVID-19." Image size: 900x600 for web; 75% scale in email](https://twin-cities.umn.edu/sites/twin-cities.umn.edu/files/Unews%20Image%20Templates%203_2%20%281%29.jpg) New U of M research examines the specific ways SARS-CoV-2 impacts the brain. Credit: University of Minnesota Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and “brain fog.” Published in [Frontiers in Microbiology](https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1404312/full?utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field&journalName=Frontiers_in_Microbiology&id=1404312), the researchers examined the specific ways the virus impacts the brain, developing a preclinical model to accurately mimic the effects of COVID-19 on humans to explore the impact of age and sex on the brain-related impacts of the disease. The study was led by Maxim Cheeran in the College of Veterinary Medicine, Ling Li in the College of Pharmacy and Walter Low in the Medical School. The findings include: - SARS-CoV-2 infection triggered a neuroinflammatory response, despite the lack of detectable virus in the brain. - Older age males showed a higher viral load and more pronounced symptoms. - Older age also led to increased neurological inflammation. The researchers also found several biological pathways that the virus impacts in the brain, including overactive or misdirected immune response, disruption to the protective blood-brain barrier, damage to cells lining blood vessels, and impacts to how nerve cells are formed and function. These impacts can impair brain function and may even lead to permanent damage. “There are still things we don’t know about how coronavirus infection affects the brain, and our research is beginning to unravel the mystery,” said Cheeran. “We now know that viral infection in the lungs can cause inflammatory changes in the brain, affected by the age and sex of the patient. With this model, we can further examine the connections between the infected lung and the brain, and start development on targeted treatments to mitigate the impact of COVID-19 on the brain.” In addition to new targeted therapies, these findings allow for more accurate vaccine development and continued research. The research team has a study underway that could shed light on the persistence of these symptoms in individuals experiencing long COVID, including the long-term impacts on neurocognitive behavior and memory loss. This work was supported in part by grants from the National Institutes of Health/National Institute on Aging and the SURRGE award program of the University of Minnesota’s College of Pharmacy. \-30- About the College of Veterinary Medicine The University of Minnesota College of Veterinary Medicine affects the lives of animals and people every day through educational, research, service, and outreach programs. Established in 1947, the University of Minnesota College of Veterinary Medicine is Minnesota’s only veterinary college. Fully accredited, the college has graduated over 4,000 veterinarians and hundreds of scientists. The college is also home to the Veterinary Medical Center, the Veterinary Diagnostic Laboratory, the Leatherdale Equine Center and The Raptor Center. Learn more at vetmed.umn.edu. About the College of Pharmacy Founded in 1892, the University of Minnesota College of Pharmacy is the only pharmacy school in Minnesota, with campuses in the Twin Cities and in Duluth. The College of Pharmacy improves health through innovative education, pioneering research and interdisciplinary practice development that attends to the diverse needs of the people of Minnesota and the world. Learn more at pharmacy.umn.edu. About the Medical School The University of Minnesota Medical School is at the forefront of learning and discovery, transforming medical care and educating the next generation of physicians. Our graduates and faculty produce high-impact biomedical research and advance the practice of medicine. We acknowledge that the U of M Medical School is located on traditional, ancestral and contemporary lands of the Dakota and the Ojibwe, and scores of other Indigenous people, and we affirm our commitment to tribal communities and their sovereignty as we seek to improve and strengthen our relations with tribal nations. 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