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| Last Crawled | 2026-04-14 18:40:29 (3 days ago) |
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| Meta Title | Is It Dangerous to Keep Getting COVID-19? |
| Meta Description | Common as they are, reinfections may come with lasting impacts. |
| Meta Canonical | null |
| Boilerpipe Text | Getting COVID-19 today is much less scary and more common than it was three years ago. By now, many people have had it not just once, but two, three, or even more times. Most of the time, repeat infections aren't as severe as they were the first time, leading to a sense of complacency about getting COVID-19 over and over.
But reinfections aren't harmless. As cases continue to rise and more
variants arrive on the scene
, infectious-disease experts are warning that repeat infections could have cumulative, lasting effects.
âThere is some early evidence starting to show that if you had COVID-19, there can be all sorts of problems after getting infectedâ and reinfected, says Dr. Robert Murphy, professor of medicine and executive director of the Havey Institute for Global Health at Northwesternâs Feinberg School of Medicine. âWe are just at the beginning of learning about them.â
A higher risk of Long COVID
Dr. Ziyad Al-Aly, clinical epidemiologist at Washington University in St. Louis,
studies Long COVID
: a condition marked by health effects that linger after infection. âReinfection remains consequential,â he says.
In a
paper published in Nature Medicine
in 2022, he found that people who had gotten COVID-19 at least twice experienced higher rates of short- and long-term health effects, including heart, lung, and brain issues, compared to those who were only infected once.
More From TIME
But why? Dr. Davey Smith, a virologist and head of infectious diseases at University of California San Diego, says that certain characteristicsâsuch as older ageâmay make people more vulnerable to complications after repeat bouts. âThe older you get, the worse you do with viruses in general, but specifically with SARS-CoV-2,â he says. âEvery time you get COVID-19 again and again, you increase the likelihood of having a worse infection just based on age."
Underlying health conditions that people may not necessarily be aware ofâlike prediabetes or increased inflammationâcould also put them at higher risk after each infection. âFor somebody who is already on the edge of developing diabetes and then gets COVID-19, that could damage the pancreas and the endocrine system enough to change things,â Smith says. Similarly, having high rates of inflammation before COVID-19 could raise the risk of heart events such as stroke or a heart attack after an infection.
Regardless of a person's health status, each COVID-19 infection can raise the risk of developing blood clots, which can travel to the brain or lungs. Thatâs why Smith believes anyone who is eligible for antiviral drugs such as
Paxlovid
should take them, since controlling the virus as quickly as possible can reduce any potential long-term or lingering effects an infection can have on the body.
COVID-19 may alter the immune response
At this point, many people view COVID-19 as relatively benign. But even if you've already recovered from a mild case, there's no guarantee that next time will go as smoothly. "Just because you did okay with it last year doesnât mean youâll do okay with it this year,â Smith says.
âThere is a mischaracterization in the public understanding that you can get an acute infection with fever, cough, malaise, and fatigue, get over it after a few days or a week or so, then bounce back, and itâs gone,â says Al-Aly.
âThe data are showing that [some] people still display increased risk of problems even two years after an infection.â
Thatâs what he found in his study. People who had multiple infections were three times more likely to be hospitalized for their infection up to six months later than those who only got COVID-19 once, and were also more likely to have problems with clotting, gastrointestinal disorders, kidney, and mental-health symptoms. The risks appeared to increase the more infections people experienced.
Understanding why SARS-CoV-2 has a uniquely lasting effect on the body remains a challenge. Historically, when the immune system meets a new pathogen like a virus, it generates novel defenses and remembers the intruder, so it has a head start if the virus returns. Thatâs certainly the case with SARS-CoV-2âwhich is why vaccines work, and why getting reinfected generally leads to milder symptoms.
But there is also growing evidence that in some people, getting COVID-19 the first time may compromise the immune response in a way that makes the body less likely to respond effectively the next time it sees the virus. That could leave certain organs and body systems, such as the
brain
, weaker for months after infectionâand subsequent ones. âItâs the balance of these two opposing forcesâthe immune system learning from the past and knowing how to deal with a virus and do a better job the second and third time around, and the idea that a first encounter with a virus might alter the immune system in some way that it becomes less efficientâthat could explain why some people get Long COVID,â says Al-Aly.
Data also continue to show that even vaccinated people can get Long COVIDâalthough the risk may be lowerâsince the protection provided by vaccines wanes over time, just as it does from infections. Vaccines are therefore a strong but not absolute barrier to the virus.
Preventing reinfections
âEach time you get hit, it does impact your body, so letâs try not to get it too many times,â says Smith. Thatâs easier said than done, since after three years, people are tired of taking precautions such as wearing masks and avoiding crowded public spaces. âWeâve lost the public-health battle; there is no appetite for public masking or stringent public health measures,â says Al-Aly.
That means other strategies need to become available, including universal vaccines that can protect against multiple variants and
nasal spray vaccines
that stand guard at the nose, which is where SARS-CoV-2 generally enters. Researchers are currently testing these next generation shots, so while âthe good news is that these technologies do exist, they need to be accelerated and brought to market as soon as possible to protect the public,â says Al-Aly.
In the meantime, Smith says itâs important for people to understand that they still need to do everything they can to avoid getting COVID-19. That means staying up to date with vaccinations and taking some basic precautions, such as wearing
high-quality masks
indoors when cases are high, especially in crowded places and on public transportation.
âI wish we lived in a world where getting repeat infections doesnât matter," says Al-Aly, "but the reality is thatâs not the case." |
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# Is It Dangerous to Keep Getting COVID-19?
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by
[Alice Park](https://time.com/author/alice-park/)
Senior Correspondent
Updated:
Jan 19, 2026 9:58 AM CUT
Published:
Jan 10, 2024 3:19 PM CUT

Close-up of a hand holding a positive antigen test for COVID-19. SARS-CoV-2 antigen rapid test kit.
Close-up of a hand holding a positive antigen test for COVID-19. SARS-CoV-2 antigen rapid test kit.Getty Images

by
[Alice Park](https://time.com/author/alice-park/)
Senior Correspondent
Updated:
Jan 19, 2026 9:58 AM CUT
Published:
Jan 10, 2024 3:19 PM CUT
Getting COVID-19 today is much less scary and more common than it was three years ago. By now, many people have had it not just once, but two, three, or even more times. Most of the time, repeat infections aren't as severe as they were the first time, leading to a sense of complacency about getting COVID-19 over and over.
But reinfections aren't harmless. As cases continue to rise and more [variants arrive on the scene](https://covid.cdc.gov/covid-data-tracker/#variant-summary "undefined"), infectious-disease experts are warning that repeat infections could have cumulative, lasting effects.
âThere is some early evidence starting to show that if you had COVID-19, there can be all sorts of problems after getting infectedâ and reinfected, says Dr. Robert Murphy, professor of medicine and executive director of the Havey Institute for Global Health at Northwesternâs Feinberg School of Medicine. âWe are just at the beginning of learning about them.â
## A higher risk of Long COVID
Dr. Ziyad Al-Aly, clinical epidemiologist at Washington University in St. Louis, [studies Long COVID](https://time.com/6232103/covid-19-reinfections-effects/ "undefined"): a condition marked by health effects that linger after infection. âReinfection remains consequential,â he says.
In a [paper published in Nature Medicine](https://pubmed.ncbi.nlm.nih.gov/36357676/ "undefined") in 2022, he found that people who had gotten COVID-19 at least twice experienced higher rates of short- and long-term health effects, including heart, lung, and brain issues, compared to those who were only infected once.
### More From TIME
Advertisement
But why? Dr. Davey Smith, a virologist and head of infectious diseases at University of California San Diego, says that certain characteristicsâsuch as older ageâmay make people more vulnerable to complications after repeat bouts. âThe older you get, the worse you do with viruses in general, but specifically with SARS-CoV-2,â he says. âEvery time you get COVID-19 again and again, you increase the likelihood of having a worse infection just based on age."
Underlying health conditions that people may not necessarily be aware ofâlike prediabetes or increased inflammationâcould also put them at higher risk after each infection. âFor somebody who is already on the edge of developing diabetes and then gets COVID-19, that could damage the pancreas and the endocrine system enough to change things,â Smith says. Similarly, having high rates of inflammation before COVID-19 could raise the risk of heart events such as stroke or a heart attack after an infection.
Advertisement
Regardless of a person's health status, each COVID-19 infection can raise the risk of developing blood clots, which can travel to the brain or lungs. Thatâs why Smith believes anyone who is eligible for antiviral drugs such as [Paxlovid](https://time.com/6553027/paxlovid-for-young-healthy-adults/ "undefined") should take them, since controlling the virus as quickly as possible can reduce any potential long-term or lingering effects an infection can have on the body.
## COVID-19 may alter the immune response
At this point, many people view COVID-19 as relatively benign. But even if you've already recovered from a mild case, there's no guarantee that next time will go as smoothly. "Just because you did okay with it last year doesnât mean youâll do okay with it this year,â Smith says.
âThere is a mischaracterization in the public understanding that you can get an acute infection with fever, cough, malaise, and fatigue, get over it after a few days or a week or so, then bounce back, and itâs gone,â says Al-Aly.âThe data are showing that \[some\] people still display increased risk of problems even two years after an infection.â
Advertisement
Thatâs what he found in his study. People who had multiple infections were three times more likely to be hospitalized for their infection up to six months later than those who only got COVID-19 once, and were also more likely to have problems with clotting, gastrointestinal disorders, kidney, and mental-health symptoms. The risks appeared to increase the more infections people experienced.
Understanding why SARS-CoV-2 has a uniquely lasting effect on the body remains a challenge. Historically, when the immune system meets a new pathogen like a virus, it generates novel defenses and remembers the intruder, so it has a head start if the virus returns. Thatâs certainly the case with SARS-CoV-2âwhich is why vaccines work, and why getting reinfected generally leads to milder symptoms.
But there is also growing evidence that in some people, getting COVID-19 the first time may compromise the immune response in a way that makes the body less likely to respond effectively the next time it sees the virus. That could leave certain organs and body systems, such as the [brain](https://www.abstractsonline.com/pp8/#!/10619/presentation/69863 "undefined"), weaker for months after infectionâand subsequent ones. âItâs the balance of these two opposing forcesâthe immune system learning from the past and knowing how to deal with a virus and do a better job the second and third time around, and the idea that a first encounter with a virus might alter the immune system in some way that it becomes less efficientâthat could explain why some people get Long COVID,â says Al-Aly.
Advertisement
Data also continue to show that even vaccinated people can get Long COVIDâalthough the risk may be lowerâsince the protection provided by vaccines wanes over time, just as it does from infections. Vaccines are therefore a strong but not absolute barrier to the virus.
## Preventing reinfections
âEach time you get hit, it does impact your body, so letâs try not to get it too many times,â says Smith. Thatâs easier said than done, since after three years, people are tired of taking precautions such as wearing masks and avoiding crowded public spaces. âWeâve lost the public-health battle; there is no appetite for public masking or stringent public health measures,â says Al-Aly.
That means other strategies need to become available, including universal vaccines that can protect against multiple variants and [nasal spray vaccines](https://time.com/6226356/nasal-vaccine-covid-19-us-update/ "undefined") that stand guard at the nose, which is where SARS-CoV-2 generally enters. Researchers are currently testing these next generation shots, so while âthe good news is that these technologies do exist, they need to be accelerated and brought to market as soon as possible to protect the public,â says Al-Aly.
Advertisement
In the meantime, Smith says itâs important for people to understand that they still need to do everything they can to avoid getting COVID-19. That means staying up to date with vaccinations and taking some basic precautions, such as wearing [high-quality masks](https://time.com/6139169/n95-best-mask-omicron-covid-19/ "undefined") indoors when cases are high, especially in crowded places and on public transportation.
âI wish we lived in a world where getting repeat infections doesnât matter," says Al-Aly, "but the reality is thatâs not the case."
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- [Starmer Says He's 'Fed Up' With Trump as Europe Splinters From U.S. Over Iran War](https://time.com/article/2026/04/10/european-leaders-criticize-trump-over-iran-war-starmer-energy-prices/?utm_rs=IL_GNBazf4RR9GSs3N-N37Btw)
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| Readable Markdown | Getting COVID-19 today is much less scary and more common than it was three years ago. By now, many people have had it not just once, but two, three, or even more times. Most of the time, repeat infections aren't as severe as they were the first time, leading to a sense of complacency about getting COVID-19 over and over.
But reinfections aren't harmless. As cases continue to rise and more [variants arrive on the scene](https://covid.cdc.gov/covid-data-tracker/#variant-summary "undefined"), infectious-disease experts are warning that repeat infections could have cumulative, lasting effects.
âThere is some early evidence starting to show that if you had COVID-19, there can be all sorts of problems after getting infectedâ and reinfected, says Dr. Robert Murphy, professor of medicine and executive director of the Havey Institute for Global Health at Northwesternâs Feinberg School of Medicine. âWe are just at the beginning of learning about them.â
A higher risk of Long COVID
Dr. Ziyad Al-Aly, clinical epidemiologist at Washington University in St. Louis, [studies Long COVID](https://time.com/6232103/covid-19-reinfections-effects/ "undefined"): a condition marked by health effects that linger after infection. âReinfection remains consequential,â he says.
In a [paper published in Nature Medicine](https://pubmed.ncbi.nlm.nih.gov/36357676/ "undefined") in 2022, he found that people who had gotten COVID-19 at least twice experienced higher rates of short- and long-term health effects, including heart, lung, and brain issues, compared to those who were only infected once.
More From TIME
But why? Dr. Davey Smith, a virologist and head of infectious diseases at University of California San Diego, says that certain characteristicsâsuch as older ageâmay make people more vulnerable to complications after repeat bouts. âThe older you get, the worse you do with viruses in general, but specifically with SARS-CoV-2,â he says. âEvery time you get COVID-19 again and again, you increase the likelihood of having a worse infection just based on age."
Underlying health conditions that people may not necessarily be aware ofâlike prediabetes or increased inflammationâcould also put them at higher risk after each infection. âFor somebody who is already on the edge of developing diabetes and then gets COVID-19, that could damage the pancreas and the endocrine system enough to change things,â Smith says. Similarly, having high rates of inflammation before COVID-19 could raise the risk of heart events such as stroke or a heart attack after an infection.
Regardless of a person's health status, each COVID-19 infection can raise the risk of developing blood clots, which can travel to the brain or lungs. Thatâs why Smith believes anyone who is eligible for antiviral drugs such as [Paxlovid](https://time.com/6553027/paxlovid-for-young-healthy-adults/ "undefined") should take them, since controlling the virus as quickly as possible can reduce any potential long-term or lingering effects an infection can have on the body.
COVID-19 may alter the immune response
At this point, many people view COVID-19 as relatively benign. But even if you've already recovered from a mild case, there's no guarantee that next time will go as smoothly. "Just because you did okay with it last year doesnât mean youâll do okay with it this year,â Smith says.
âThere is a mischaracterization in the public understanding that you can get an acute infection with fever, cough, malaise, and fatigue, get over it after a few days or a week or so, then bounce back, and itâs gone,â says Al-Aly.âThe data are showing that \[some\] people still display increased risk of problems even two years after an infection.â
Thatâs what he found in his study. People who had multiple infections were three times more likely to be hospitalized for their infection up to six months later than those who only got COVID-19 once, and were also more likely to have problems with clotting, gastrointestinal disorders, kidney, and mental-health symptoms. The risks appeared to increase the more infections people experienced.
Understanding why SARS-CoV-2 has a uniquely lasting effect on the body remains a challenge. Historically, when the immune system meets a new pathogen like a virus, it generates novel defenses and remembers the intruder, so it has a head start if the virus returns. Thatâs certainly the case with SARS-CoV-2âwhich is why vaccines work, and why getting reinfected generally leads to milder symptoms.
But there is also growing evidence that in some people, getting COVID-19 the first time may compromise the immune response in a way that makes the body less likely to respond effectively the next time it sees the virus. That could leave certain organs and body systems, such as the [brain](https://www.abstractsonline.com/pp8/#!/10619/presentation/69863 "undefined"), weaker for months after infectionâand subsequent ones. âItâs the balance of these two opposing forcesâthe immune system learning from the past and knowing how to deal with a virus and do a better job the second and third time around, and the idea that a first encounter with a virus might alter the immune system in some way that it becomes less efficientâthat could explain why some people get Long COVID,â says Al-Aly.
Data also continue to show that even vaccinated people can get Long COVIDâalthough the risk may be lowerâsince the protection provided by vaccines wanes over time, just as it does from infections. Vaccines are therefore a strong but not absolute barrier to the virus.
Preventing reinfections
âEach time you get hit, it does impact your body, so letâs try not to get it too many times,â says Smith. Thatâs easier said than done, since after three years, people are tired of taking precautions such as wearing masks and avoiding crowded public spaces. âWeâve lost the public-health battle; there is no appetite for public masking or stringent public health measures,â says Al-Aly.
That means other strategies need to become available, including universal vaccines that can protect against multiple variants and [nasal spray vaccines](https://time.com/6226356/nasal-vaccine-covid-19-us-update/ "undefined") that stand guard at the nose, which is where SARS-CoV-2 generally enters. Researchers are currently testing these next generation shots, so while âthe good news is that these technologies do exist, they need to be accelerated and brought to market as soon as possible to protect the public,â says Al-Aly.
In the meantime, Smith says itâs important for people to understand that they still need to do everything they can to avoid getting COVID-19. That means staying up to date with vaccinations and taking some basic precautions, such as wearing [high-quality masks](https://time.com/6139169/n95-best-mask-omicron-covid-19/ "undefined") indoors when cases are high, especially in crowded places and on public transportation.
âI wish we lived in a world where getting repeat infections doesnât matter," says Al-Aly, "but the reality is thatâs not the case." |
| Shard | 39 (laksa) |
| Root Hash | 9797552172251460839 |
| Unparsed URL | com,time!/6553340/covid-19-reinfection-risk/ s443 |