🕷️ Crawler Inspector

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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 19 (from laksa106)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa019.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/\')), getAhrefsUnparsedNoserviceFromURL(\'https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/","crawl_time":1775694221,"first_indexed_time":1772539474,"http_code":200,"src_unparsed":"com,scitechdaily!\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/ s443","src_root_hash":"8068689860169301019","history_drop_reason":null,"meta_title":"Even Mild COVID-19 Can Leave Lasting Brain Damage, Study Finds","meta_descriptions":["A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade."],"attrs_boilerpipe_text":"New research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock\nA new study suggests that recovery from\nCOVID-19\nmay not end when respiratory symptoms fade.\nA mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from\nTulane University\nsuggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months.\nThe research team found that both viruses can cause lasting damage in the lungs. However, only infection with\nSARS-CoV-2\nwas linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the\nvirus\ncould no longer be detected. The study, published in\nFrontiers in Immunology\n, offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems.\n“Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center.\nComparing the Lingering Effects of Two Viruses\nTo determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared.\nIn lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses.\nA closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly.\nPersistent Brain Changes After COVID-19\nThe most striking differences appeared in the brain.\nNeither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate\nserotonin\nand\ndopamine\n, which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza.\n“In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.”\nThe study was supported by an\nAmerican Heart Association award\nQin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms.\nBy identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact.\nReference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026,\nFrontiers in Immunology\n.\nDOI: 10.3389\/fimmu.2026.1755141\nThis research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the\nNational Institutes of Health\n, including P51OD011104-62 and R01HL165265, and institutional funding.\nNever miss a breakthrough:\nJoin the SciTechDaily newsletter.\nFollow us on\nGoogle\nand\nGoogle News\n.","attrs_markdown":"[Close Menu](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/)\n\n[Facebook](https:\/\/www.facebook.com\/scitechdaily)   [X (Twitter)](https:\/\/twitter.com\/SciTechDaily1)   [Instagram](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/)\n\n[![SciTechDaily](https:\/\/scitechdaily.com\/images\/scitechdaily-logo-flat-40.png)](https:\/\/scitechdaily.com\/ \"SciTechDaily\")\n\n- [Biology](https:\/\/scitechdaily.com\/news\/biology\/)\n- 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Finds\n\n[Health](https:\/\/scitechdaily.com\/news\/health\/)\n\n# Even Mild COVID-19 Can Leave Lasting Brain Damage, Study Finds\nBy Tulane University\n\nMarch 3, 2026\n\n[6 Comments](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comments)4 Mins Read\n\n[Facebook](https:\/\/www.facebook.com\/sharer.php?u=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F \"Share on Facebook\")   [Twitter](https:\/\/twitter.com\/intent\/tweet?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&text=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds \"Share on X (Twitter)\")   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Coronavirus Paritcles](https:\/\/scitechdaily.com\/images\/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles-777x518.jpg)](https:\/\/scitechdaily.com\/images\/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg)\n\nNew research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock\n### A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade.\nA mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from [Tulane University](https:\/\/scitechdaily.com\/tag\/tulane-university\/) suggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months.\n\nThe research team found that both viruses can cause lasting damage in the lungs. However, only infection with SARS-CoV-2 was linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the virus could no longer be detected. The study, published in *Frontiers in Immunology*, offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems.\n\n“Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center.\n\n#### Comparing the Lingering Effects of Two Viruses\nTo determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared.\n\nIn lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses.\n\nA closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly.\n\n#### Persistent Brain Changes After COVID-19\nThe most striking differences appeared in the brain.\n\nNeither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate serotonin and dopamine, which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza.\n\n“In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.”\n\nThe study was supported by an [American Heart Association award](https:\/\/medicine.tulane.edu\/news\/tulane-researchers-receive-american-heart-association-grant-study-covid%E2%80%99s-vascular-effects) Qin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms.\n\nBy identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact.\n\nReference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026, *Frontiers in Immunology*.  \n [DOI: 10.3389\/fimmu.2026.1755141](https:\/\/doi.org\/10.3389\/fimmu.2026.1755141)\n\nThis research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the National Institutes of Health, including P51OD011104-62 and R01HL165265, and institutional funding.\n\n**Never miss a breakthrough: [Join the SciTechDaily newsletter.](https:\/\/scitechdaily.com\/newsletter\/)**  \n**Follow us on [Google](https:\/\/www.google.com\/preferences\/source?q=scitechdaily.com) and [Google News](https:\/\/news.google.com\/publications\/CAAqLAgKIiZDQklTRmdnTWFoSUtFSE5qYVhSbFkyaGtZV2xzZVM1amIyMG9BQVAB?hl=en-US&gl=US&ceid=US%3Aen).**\n\n[COVID-19](https:\/\/scitechdaily.com\/tag\/covid-19\/) [Infectious Diseases](https:\/\/scitechdaily.com\/tag\/infectious-diseases\/) [Long COVID](https:\/\/scitechdaily.com\/tag\/long-covid\/) [Neurology](https:\/\/scitechdaily.com\/tag\/neurology\/) [Tulane University](https:\/\/scitechdaily.com\/tag\/tulane-university\/)\n\nShare.   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I never took the Covid shots, had Covid twice and fully recovered w\/o any after effects.\n   \n   These researchers need to find out what causes some to suffer more than others.\n   \n   [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=976240#respond)\n2. ![](https:\/\/secure.gravatar.com\/avatar\/d743a1e38dbb2be34c73d62de7fa6e7e355297815dddf23d4b2bf7c47cd8624f?s=45&d=identicon&r=pg)\n   \n   Keith Kinsmore on\n   \n   [March 3, 2026 1:09 pm](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comment-976259 \"March 3, 2026 at 1:09 pm\")\n   \n   Covid19 resulting from isocyanate poisioning, destroying oxygen salts just the beginning, toxicity destroying oxygen internally and atmospherically no exceptions.\n   \n   [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=976259#respond)\n3. ![](https:\/\/secure.gravatar.com\/avatar\/?s=45&d=identicon&r=pg)\n   \n   Boba on\n   \n   [March 4, 2026 1:28 am](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comment-976517 \"March 4, 2026 at 1:28 am\")\n   \n   Well, covid sure made a lot of people fascists, so…\n   \n   [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=976517#respond)\n4. ![](https:\/\/secure.gravatar.com\/avatar\/acec376517dc10ca271fec8edad063dd33a89c9d04efe5b8dd989ed9ee219df6?s=45&d=identicon&r=pg)\n   \n   Eric M. Jones on\n   \n   [March 4, 2026 7:16 am](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comment-976583 \"March 4, 2026 at 7:16 am\")\n   \n   So many people avoided the vaccines and voted for Trump. Coincidence? Maybe not.\n   \n   [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=976583#respond)\n   - ![](https:\/\/secure.gravatar.com\/avatar\/c96d829edb46801c89d1975adc0ced79a92590fe4e5b59a4caaecb3c491423af?s=45&d=identicon&r=pg)\n     \n     TJ on\n     \n     [March 11, 2026 8:31 am](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comment-981340 \"March 11, 2026 at 8:31 am\")\n     \n     Just keep taking your boosters and everything will be okay 😉\n     \n     [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=981340#respond)\n5. ![](https:\/\/secure.gravatar.com\/avatar\/c96d829edb46801c89d1975adc0ced79a92590fe4e5b59a4caaecb3c491423af?s=45&d=identicon&r=pg)\n   \n   TJ on\n   \n   [March 11, 2026 8:31 am](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#comment-981339 \"March 11, 2026 at 8:31 am\")\n   \n   Just keep taking your boosters and everything will be okay 😉\n   \n   [Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/?replytocom=981339#respond)\n\nLeave A Reply\n\n[Cancel Reply](https:\/\/scitechdaily.com\/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds\/#respond)\n\n- [Facebook](https:\/\/www.facebook.com\/scitechdaily)\n- [Twitter](https:\/\/twitter.com\/SciTechDaily1)\n- [Pinterest](https:\/\/www.pinterest.com\/scitechdaily\/)\n- [YouTube](https:\/\/www.youtube.com\/@SciTechDaily)\n\n### Don't Miss a Discovery\nSubscribe for the Latest in Science & Tech\\!\n\n##### Trending News\n#### [Even Occasional Binge Drinking May Triple Liver Damage Risk](https:\/\/scitechdaily.com\/even-occasional-binge-drinking-may-triple-liver-damage-risk\/)\n#### [Liftoff! 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All Rights Reserved.\n\n- [Science News](https:\/\/scitechdaily.com\/ \"Science and Technology News\")\n- [About](https:\/\/scitechdaily.com\/about-us\/ \"About SciTechDaily\")\n- [Contact](https:\/\/scitechdaily.com\/contact\/ \"Contact SciTechDaily.com\")\n- [Editorial Board](https:\/\/scitechdaily.com\/editorial-board\/ \"SciTechDaily Editorial Board\")\n- [Privacy Policy](https:\/\/scitechdaily.com\/privacy-policy\/)\n- [Terms of Use](https:\/\/scitechdaily.com\/terms\/)","attrs_readable_markdown":"[![Senior Man COVID Face Mask Coronavirus Paritcles](https:\/\/scitechdaily.com\/images\/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles-777x518.jpg)](https:\/\/scitechdaily.com\/images\/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg)\n\nNew research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock\n### A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade.\nA mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from [Tulane University](https:\/\/scitechdaily.com\/tag\/tulane-university\/) suggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months.\n\nThe research team found that both viruses can cause lasting damage in the lungs. However, only infection with SARS-CoV-2 was linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the virus could no longer be detected. The study, published in *Frontiers in Immunology*, offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems.\n\n“Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center.\n\n#### Comparing the Lingering Effects of Two Viruses\nTo determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared.\n\nIn lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses.\n\nA closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly.\n\n#### Persistent Brain Changes After COVID-19\nThe most striking differences appeared in the brain.\n\nNeither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate serotonin and dopamine, which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza.\n\n“In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.”\n\nThe study was supported by an [American Heart Association award](https:\/\/medicine.tulane.edu\/news\/tulane-researchers-receive-american-heart-association-grant-study-covid%E2%80%99s-vascular-effects) Qin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms.\n\nBy identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact.\n\nReference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026, *Frontiers in Immunology*.  \n [DOI: 10.3389\/fimmu.2026.1755141](https:\/\/doi.org\/10.3389\/fimmu.2026.1755141)\n\nThis research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the National Institutes of Health, including P51OD011104-62 and R01HL165265, and institutional funding.\n\n**Never miss a breakthrough: [Join the SciTechDaily newsletter.](https:\/\/scitechdaily.com\/newsletter\/)**  \n**Follow us on [Google](https:\/\/www.google.com\/preferences\/source?q=scitechdaily.com) and [Google News](https:\/\/news.google.com\/publications\/CAAqLAgKIiZDQklTRmdnTWFoSUtFSE5qYVhSbFkyaGtZV2xzZVM1amIyMG9BQVAB?hl=en-US&gl=US&ceid=US%3Aen).**","meta_canonical":null}

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Boilerpipe Text	New research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade. A mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from Tulane University suggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months. The research team found that both viruses can cause lasting damage in the lungs. However, only infection with SARS-CoV-2 was linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the virus could no longer be detected. The study, published in Frontiers in Immunology , offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems. “Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center. Comparing the Lingering Effects of Two Viruses To determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared. In lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses. A closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly. Persistent Brain Changes After COVID-19 The most striking differences appeared in the brain. Neither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate serotonin and dopamine , which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza. “In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.” The study was supported by an American Heart Association award Qin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms. By identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact. Reference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026, Frontiers in Immunology . DOI: 10.3389/fimmu.2026.1755141 This research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the National Institutes of Health , including P51OD011104-62 and R01HL165265, and institutional funding. Never miss a breakthrough: Join the SciTechDaily newsletter. Follow us on Google and Google News .
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Even Mild COVID-19 Can Leave Lasting Brain Damage, Study Finds By Tulane University March 3, 2026 [6 Comments](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comments)4 Mins Read [Facebook](https://www.facebook.com/sharer.php?u=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F "Share on Facebook") [Twitter](https://twitter.com/intent/tweet?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&text=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Share on X (Twitter)") [Pinterest](https://pinterest.com/pin/create/button/?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&media=https%3A%2F%2Fscitechdaily.com%2Fimages%2FSenior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg&description=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Share on Pinterest") [Telegram](https://t.me/share/url?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&title=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Share on Telegram") [LinkedIn](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F "Share on LinkedIn") [WhatsApp](https://wa.me/?text=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds%20https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F "Share on WhatsApp") [Email](https://scitechdaily.com/cdn-cgi/l/email-protection#744b0701161e111700493102111a514644391d1810514644373b223d3059454d51464437151a5146443811150211514644381507001d1a135146443606151d1a514644301519151311514637514644270001100d514644321d1a1007525744474c4f161b100d491c0000040751473551463251463207171d0011171c10151d180d5a171b195146321102111a59191d181059171b021d1059454d5917151a59181115021159181507001d1a13591606151d1a5910151915131159070001100d59121d1a1007514632 "Share via Email") [Reddit](https://www.reddit.com/submit?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&title=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Share on Reddit") Share [Facebook](https://www.facebook.com/sharer.php?u=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F "Facebook") [Twitter](https://twitter.com/intent/tweet?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&text=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Twitter") [LinkedIn](https://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F "LinkedIn") [Pinterest](https://pinterest.com/pin/create/button/?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&media=https%3A%2F%2Fscitechdaily.com%2Fimages%2FSenior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg&description=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Pinterest") [Telegram](https://t.me/share/url?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&title=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Telegram") [Email](https://scitechdaily.com/cdn-cgi/l/email-protection#4e713d3b2c242b2d3a730b382b206b7c7e0327222a6b7c7e0d0118070a637f776b7c7e0d2f206b7c7e022b2f382b6b7c7e022f3d3a2720296b7c7e0c3c2f27206b7c7e0a2f232f292b6b7c0d6b7c7e1d3a3b2a376b7c7e0827202a3d682c212a3773263a3a3e3d6b7d0f6b7c086b7c083d2d273a2b2d262a2f272237602d21236b7c082b382b20632327222a632d2138272a637f77632d2f2063222b2f382b63222f3d3a272029632c3c2f2720632a2f232f292b633d3a3b2a37632827202a3d6b7c08 "Email") [Reddit](https://www.reddit.com/submit?url=https%3A%2F%2Fscitechdaily.com%2Feven-mild-covid-19-can-leave-lasting-brain-damage-study-finds%2F&title=Even%20Mild%20COVID-19%20Can%20Leave%20Lasting%20Brain%20Damage%2C%20Study%20Finds "Reddit") [![Senior Man COVID Face Mask Coronavirus Paritcles](https://scitechdaily.com/images/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles-777x518.jpg)](https://scitechdaily.com/images/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg) New research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock ### A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade. A mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from [Tulane University](https://scitechdaily.com/tag/tulane-university/) suggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months. The research team found that both viruses can cause lasting damage in the lungs. However, only infection with SARS-CoV-2 was linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the virus could no longer be detected. The study, published in Frontiers in Immunology, offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems. “Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center. #### Comparing the Lingering Effects of Two Viruses To determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared. In lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses. A closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly. #### Persistent Brain Changes After COVID-19 The most striking differences appeared in the brain. Neither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate serotonin and dopamine, which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza. “In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.” The study was supported by an [American Heart Association award](https://medicine.tulane.edu/news/tulane-researchers-receive-american-heart-association-grant-study-covid%E2%80%99s-vascular-effects) Qin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms. By identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact. Reference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026, Frontiers in Immunology. [DOI: 10.3389/fimmu.2026.1755141](https://doi.org/10.3389/fimmu.2026.1755141) This research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the National Institutes of Health, including P51OD011104-62 and R01HL165265, and institutional funding. Never miss a breakthrough: [Join the SciTechDaily newsletter.](https://scitechdaily.com/newsletter/) Follow us on [Google](https://www.google.com/preferences/source?q=scitechdaily.com) and [Google News](https://news.google.com/publications/CAAqLAgKIiZDQklTRmdnTWFoSUtFSE5qYVhSbFkyaGtZV2xzZVM1amIyMG9BQVAB?hl=en-US&gl=US&ceid=US%3Aen). [COVID-19](https://scitechdaily.com/tag/covid-19/) [Infectious Diseases](https://scitechdaily.com/tag/infectious-diseases/) [Long COVID](https://scitechdaily.com/tag/long-covid/) [Neurology](https://scitechdaily.com/tag/neurology/) [Tulane University](https://scitechdaily.com/tag/tulane-university/) Share. 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I never took the Covid shots, had Covid twice and fully recovered w/o any after effects. These researchers need to find out what causes some to suffer more than others. [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=976240#respond) 2. ![](https://secure.gravatar.com/avatar/d743a1e38dbb2be34c73d62de7fa6e7e355297815dddf23d4b2bf7c47cd8624f?s=45&d=identicon&r=pg) Keith Kinsmore on [March 3, 2026 1:09 pm](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comment-976259 "March 3, 2026 at 1:09 pm") Covid19 resulting from isocyanate poisioning, destroying oxygen salts just the beginning, toxicity destroying oxygen internally and atmospherically no exceptions. [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=976259#respond) 3. ![](https://secure.gravatar.com/avatar/?s=45&d=identicon&r=pg) Boba on [March 4, 2026 1:28 am](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comment-976517 "March 4, 2026 at 1:28 am") Well, covid sure made a lot of people fascists, so… [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=976517#respond) 4. ![](https://secure.gravatar.com/avatar/acec376517dc10ca271fec8edad063dd33a89c9d04efe5b8dd989ed9ee219df6?s=45&d=identicon&r=pg) Eric M. Jones on [March 4, 2026 7:16 am](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comment-976583 "March 4, 2026 at 7:16 am") So many people avoided the vaccines and voted for Trump. Coincidence? Maybe not. [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=976583#respond) - ![](https://secure.gravatar.com/avatar/c96d829edb46801c89d1975adc0ced79a92590fe4e5b59a4caaecb3c491423af?s=45&d=identicon&r=pg) TJ on [March 11, 2026 8:31 am](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comment-981340 "March 11, 2026 at 8:31 am") Just keep taking your boosters and everything will be okay 😉 [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=981340#respond) 5. ![](https://secure.gravatar.com/avatar/c96d829edb46801c89d1975adc0ced79a92590fe4e5b59a4caaecb3c491423af?s=45&d=identicon&r=pg) TJ on [March 11, 2026 8:31 am](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#comment-981339 "March 11, 2026 at 8:31 am") Just keep taking your boosters and everything will be okay 😉 [Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/?replytocom=981339#respond) Leave A Reply [Cancel Reply](https://scitechdaily.com/even-mild-covid-19-can-leave-lasting-brain-damage-study-finds/#respond) - [Facebook](https://www.facebook.com/scitechdaily) - [Twitter](https://twitter.com/SciTechDaily1) - [Pinterest](https://www.pinterest.com/scitechdaily/) - [YouTube](https://www.youtube.com/@SciTechDaily) ### Don't Miss a Discovery Subscribe for the Latest in Science & Tech\! ##### Trending News #### [Even Occasional Binge Drinking May Triple Liver Damage Risk](https://scitechdaily.com/even-occasional-binge-drinking-may-triple-liver-damage-risk/) #### [Liftoff! 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Readable Markdown	[![Senior Man COVID Face Mask Coronavirus Paritcles](https://scitechdaily.com/images/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles-777x518.jpg)](https://scitechdaily.com/images/Senior-Man-COVID-Face-Mask-Coronavirus-Paritcles.jpg) New research reveals that even mild respiratory infections can leave lasting biological changes. However, COVID-19 stands apart, with unique effects on the brain that may help explain long COVID. Credit: Shutterstock ### A new study suggests that recovery from COVID-19 may not end when respiratory symptoms fade. A mild bout of COVID-19 or influenza may have effects that continue long after obvious symptoms such as fever and coughing disappear. New research from [Tulane University](https://scitechdaily.com/tag/tulane-university/) suggests these hidden changes could help explain why some people do not feel fully recovered for weeks or even months. The research team found that both viruses can cause lasting damage in the lungs. However, only infection with SARS-CoV-2 was linked to ongoing inflammation in the brain and injury to tiny blood vessels, even after the virus could no longer be detected. The study, published in Frontiers in Immunology, offers insight into why long COVID is often marked by brain-related symptoms such as brain fog, fatigue, and mood changes, while influenza is more frequently associated with breathing problems. “Influenza and COVID-19 affect large populations worldwide and carry a significant public health toll, yet the mechanisms behind their long-term effects remain poorly understood,” said Dr. Xuebin Qin, lead author and professor of microbiology and immunology at the Tulane National Biomedical Research Center. #### Comparing the Lingering Effects of Two Viruses To determine which aftereffects are shared by serious respiratory infections and which are specific to COVID-19, the scientists used a mouse model. They analyzed lung and brain tissue after the infections had fully cleared. In lung tissue, the two viruses produced similar long-term patterns. Immune cells remained active instead of returning to a resting state, and collagen levels increased. Collagen is a structural protein linked to scar formation. Its buildup can stiffen lung tissue and make breathing more difficult. This may help explain why some people experience prolonged shortness of breath after respiratory illnesses. A closer look revealed an important difference. After influenza infection, the lungs appeared to begin a structured repair process. Specialized cells moved into damaged regions to rebuild the airway lining. This recovery response was largely absent following SARS-CoV-2 infection, suggesting that COVID-19 may disrupt the lungs’ ability to heal properly. #### Persistent Brain Changes After COVID-19 The most striking differences appeared in the brain. Neither virus was detected in brain tissue. However, mice that had recovered from COVID-19 showed signs of ongoing brain inflammation weeks later. Researchers also observed small areas of bleeding. An analysis of gene activity showed continued inflammatory signaling and disturbances in pathways that regulate serotonin and dopamine, which play key roles in mood, thinking, and energy. These changes were mostly absent in animals that had influenza. “In both infections, we observed lasting lung injury,” Qin said. “But long-term effects in the brain were unique to SARS-CoV-2. That distinction is critical to understanding long COVID.” The study was supported by an [American Heart Association award](https://medicine.tulane.edu/news/tulane-researchers-receive-american-heart-association-grant-study-covid%E2%80%99s-vascular-effects) Qin received as part of a national effort to understand the long-term cardiovascular and cerebrovascular effects of COVID-19. The results provide new evidence that changes in blood vessels and immune responses may contribute to ongoing neurological symptoms. By identifying these biological patterns, the researchers hope to improve how patients are monitored after infection and guide the development of treatments that could limit lasting harm. As persistent symptoms continue to affect many people, clarifying the underlying causes remains essential to reducing the long-term health impact. Reference: “Characterization of subchronic lung and brain consequences caused by mouse-adapted SARS-CoV-2 and influenza A infection of C57BL6 mice” by Joshua Currey, Chenxiao Wang, Meredith G. Mayer, Yilin Chen, Ana Karina Nisperuza Vidal, Michaela J. Allen, Mst Shamima Khatun, Calder R. Ellsworth, Mohammad Islamuddin, Jefferson Evangelista, Skye M. Minor, Nadia Golden, Kevin J. Zwezdaryk, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Derek A. Pociask, Tracy Fischer and Xuebin Qin, 23 January 2026, Frontiers in Immunology. [DOI: 10.3389/fimmu.2026.1755141](https://doi.org/10.3389/fimmu.2026.1755141) This research was supported by the American Heart Association Long COVID Impact Project (AHA962950), the National Institutes of Health, including P51OD011104-62 and R01HL165265, and institutional funding. Never miss a breakthrough: [Join the SciTechDaily newsletter.](https://scitechdaily.com/newsletter/) Follow us on [Google](https://www.google.com/preferences/source?q=scitechdaily.com) and [Google News](https://news.google.com/publications/CAAqLAgKIiZDQklTRmdnTWFoSUtFSE5qYVhSbFkyaGtZV2xzZVM1amIyMG9BQVAB?hl=en-US&gl=US&ceid=US%3Aen).
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