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URLhttps://pubmed.ncbi.nlm.nih.gov/37492805/
Last Crawled2025-08-19 01:53:02 (8 months ago)
First Indexednot set
HTTP Status Code200
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Meta TitleCommon Side Effects of Pfizer COVID-19 Vaccine: An Experience From Pakistan
Meta DescriptionIntroduction The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) epidemic spread quickly. Vaccines are now being distributed to stop the infectious spread and halt fatalities. The Pfizer-BioNTech vaccine was the first mRNA-based vaccine introduced to boost immunity against COVID-19; how …
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Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) epidemic spread quickly. Vaccines are now being distributed to stop the infectious spread and halt fatalities. The Pfizer-BioNTech vaccine was the first mRNA-based vaccine introduced to boost immunity against COVID-19; however, it could lead to various adverse reactions. Therefore, the aim of this study was to assess the prevalence of Pfizer vaccine side effects among participants. Methods This was a multicenter cross-sectional study that was performed using a non-probability sampling method. The study period was about six months from March 1, 2022, to August 31, 2022. A total of 1000 participants who received two doses of the Pfizer vaccine met the inclusion criteria. Demographic details of participants, for example, gender, age, comorbidities, Pfizer vaccine with both doses along with booster dose, previous exposure to coronavirus disease 2019 (COVID-19) infection, and the incidence of any local and systemic side effects following the first and second doses of vaccine, were reported. Results The study findings showed that out of 1000 participants, 644 (64.4%) were males and 356 (35.6%) were females; their mean age was 43.06±14.98 years. Among them, 280 (28.0%) had hypertension and 356 (35.6%) had diabetes. Following the first dose of the Pfizer vaccine, burning at the injection site and fever were the most commonly reported side effects in 704 (70.4%) and 700 (70.0%) participants, respectively. Following the second dose of the Pfizer vaccine, muscle pain was the most commonly reported side effect in 628 (62.8%) participants. Conclusion This study concluded that the most frequent adverse effects of the Pfizer vaccine were burning at the injection site, fever, pain at the injection site, muscle pain, swelling at the injection site, and joint pain. Moreover, the first dose was associated with more side effects than the second dose.
Markdown
# Common Side Effects of Pfizer COVID-19 Vaccine: An Experience From Pakistan Cureus. 2023 Jun 23;15(6):e40878. doi: 10.7759/cureus.40878. eCollection 2023 Jun. ### Authors [Syed Muhammad Safi Haider](https://pubmed.ncbi.nlm.nih.gov/?term=Haider+SMS&cauthor_id=37492805) [1](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-1 "Internal Medicine, Hamdard College of Medicine and Dentistry, Karachi, PAK.") , [Shaf Ali Alvi](https://pubmed.ncbi.nlm.nih.gov/?term=Alvi+SA&cauthor_id=37492805) [1](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-1 "Internal Medicine, Hamdard College of Medicine and Dentistry, Karachi, PAK.") , [Hamza Khan](https://pubmed.ncbi.nlm.nih.gov/?term=Khan+H&cauthor_id=37492805) [2](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-2 "General Surgery, Hamdard College of Medicine and Dentistry, Karachi, PAK.") , [Rameen Majeed](https://pubmed.ncbi.nlm.nih.gov/?term=Majeed+R&cauthor_id=37492805) [3](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-3 "Biochemistry, Jinnah Sindh Medical University, Karachi, PAK.") , [Tatheer Syed](https://pubmed.ncbi.nlm.nih.gov/?term=Syed+T&cauthor_id=37492805) [4](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-4 "Public Health, Jinnah Sindh Medical University, Karachi, PAK.") , [Adnan Anwar](https://pubmed.ncbi.nlm.nih.gov/?term=Anwar+A&cauthor_id=37492805) [5](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-5 "Physiology, Hamdard College of Medicine and Dentistry, Karachi, PAK.") [6](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-6 "Internal Medicine, Essa General Hospital, Karachi, PAK.") , [Atif A Hashmi](https://pubmed.ncbi.nlm.nih.gov/?term=Hashmi+AA&cauthor_id=37492805) [7](https://pubmed.ncbi.nlm.nih.gov/37492805/#affiliation-7 "Pathology, Liaquat National Hospital and Medical College, Karachi, PAK.") ### Affiliations - 1 Internal Medicine, Hamdard College of Medicine and Dentistry, Karachi, PAK. - 2 General Surgery, Hamdard College of Medicine and Dentistry, Karachi, PAK. - 3 Biochemistry, Jinnah Sindh Medical University, Karachi, PAK. - 4 Public Health, Jinnah Sindh Medical University, Karachi, PAK. - 5 Physiology, Hamdard College of Medicine and Dentistry, Karachi, PAK. - 6 Internal Medicine, Essa General Hospital, Karachi, PAK. - 7 Pathology, Liaquat National Hospital and Medical College, Karachi, PAK. - PMID: [37492805](https://pubmed.ncbi.nlm.nih.gov/37492805/) - PMCID: [PMC10363686](https://pmc.ncbi.nlm.nih.gov/articles/PMC10363686/) - DOI: [10\.7759/cureus.40878](https://doi.org/10.7759/cureus.40878) ## Abstract Introduction The severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) epidemic spread quickly. Vaccines are now being distributed to stop the infectious spread and halt fatalities. The Pfizer-BioNTech vaccine was the first mRNA-based vaccine introduced to boost immunity against COVID-19; however, it could lead to various adverse reactions. Therefore, the aim of this study was to assess the prevalence of Pfizer vaccine side effects among participants. Methods This was a multicenter cross-sectional study that was performed using a non-probability sampling method. The study period was about six months from March 1, 2022, to August 31, 2022. A total of 1000 participants who received two doses of the Pfizer vaccine met the inclusion criteria. Demographic details of participants, for example, gender, age, comorbidities, Pfizer vaccine with both doses along with booster dose, previous exposure to coronavirus disease 2019 (COVID-19) infection, and the incidence of any local and systemic side effects following the first and second doses of vaccine, were reported. Results The study findings showed that out of 1000 participants, 644 (64.4%) were males and 356 (35.6%) were females; their mean age was 43.06±14.98 years. Among them, 280 (28.0%) had hypertension and 356 (35.6%) had diabetes. Following the first dose of the Pfizer vaccine, burning at the injection site and fever were the most commonly reported side effects in 704 (70.4%) and 700 (70.0%) participants, respectively. Following the second dose of the Pfizer vaccine, muscle pain was the most commonly reported side effect in 628 (62.8%) participants. Conclusion This study concluded that the most frequent adverse effects of the Pfizer vaccine were burning at the injection site, fever, pain at the injection site, muscle pain, swelling at the injection site, and joint pain. Moreover, the first dose was associated with more side effects than the second dose. **Keywords:** burning; covid-19; fever; joint pain; pain; pfizer vaccine; side effects; swelling; vaccine. Copyright © 2023, Haider et al.
Readable Markdownnull
ML Classification
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97.2%
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79.1%
/Health/Public_Health/Health_Policy
77.3%
/Science
29.4%
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29.2%
/Science/Biological_Sciences/Other
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Content Metadata
Languageen
Authornull
Publish Timenot set
Original Publish Time2025-08-19 01:53:02 (8 months ago)
RepublishedNo
Word Count (Total)463
Word Count (Content)296
Links
External Links1
Internal Links9
Technical SEO
Meta NofollowYes
Meta NoarchiveYes
JS RenderedNo
Redirect Targetnull
Performance
Download Time (ms)179
TTFB (ms)177
Download Size (bytes)8,168
Shard129 (laksa)
Root Hash7295144728021232729
Unparsed URLgov,nih!nlm,ncbi,pubmed,/37492805/ s443