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URLhttps://pubmed.ncbi.nlm.nih.gov/35412612/
Last Crawled2025-12-20 04:03:37 (3 months ago)
First Indexed2022-04-13 05:37:37 (3 years ago)
HTTP Status Code200
Meta TitleComparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore
Meta DescriptionCompared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29-2.46) and 1.62 (95% CI, 1.43-1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.4 …
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Clin Infect Dis . 2022 Oct 12;75(8):1442-1445. doi: 10.1093/cid/ciac288. Affiliations 1 Ministry of Health, Singapore. 2 National Centre for Infectious Diseases, Singapore. 3 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. 4 Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 5 Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore. 6 Saw Swee Hock School of Public Health, National University of Singapore, Singapore. PMID: 35412612 PMCID: PMC9047219 DOI: 10.1093/cid/ciac288 Abstract Compared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29-2.46) and 1.62 (95% CI, 1.43-1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.42 (95% CI, 0.25-0.70) times less likely to develop severe disease. Keywords: COVID-19; SARS-CoV-2; inactivated vaccine; mRNA vaccine; vaccines. © The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. MeSH terms COVID-19 Vaccines COVID-19* / prevention & control Humans RNA, Messenger Singapore / epidemiology Vaccines, Inactivated Substances COVID-19 Vaccines RNA, Messenger Vaccines, Inactivated
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# Comparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore Clin Infect Dis. 2022 Oct 12;75(8):1442-1445. doi: 10.1093/cid/ciac288. ### Authors [M Premikha](https://pubmed.ncbi.nlm.nih.gov/?term=Premikha+M&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") , [Calvin J Chiew](https://pubmed.ncbi.nlm.nih.gov/?term=Chiew+CJ&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") , [Wycliffe E Wei](https://pubmed.ncbi.nlm.nih.gov/?term=Wei+WE&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") , [Yee Sin Leo](https://pubmed.ncbi.nlm.nih.gov/?term=Leo+YS&cauthor_id=35412612) [2](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-2 "National Centre for Infectious Diseases, Singapore.") [3](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-3 "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.") [4](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-4 "Yong Loo Lin School of Medicine, National University of Singapore, Singapore.") [5](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-5 "Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.") [6](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-6 "Saw Swee Hock School of Public Health, National University of Singapore, Singapore.") , [Benjamin Ong](https://pubmed.ncbi.nlm.nih.gov/?term=Ong+B&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") [4](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-4 "Yong Loo Lin School of Medicine, National University of Singapore, Singapore.") , [David Chien Lye](https://pubmed.ncbi.nlm.nih.gov/?term=Lye+DC&cauthor_id=35412612) [2](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-2 "National Centre for Infectious Diseases, Singapore.") [3](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-3 "Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.") [4](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-4 "Yong Loo Lin School of Medicine, National University of Singapore, Singapore.") [5](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-5 "Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.") , [Vernon J Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+VJ&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") [6](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-6 "Saw Swee Hock School of Public Health, National University of Singapore, Singapore.") , [Kelvin Bryan Tan](https://pubmed.ncbi.nlm.nih.gov/?term=Tan+KB&cauthor_id=35412612) [1](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-1 "Ministry of Health, Singapore.") [6](https://pubmed.ncbi.nlm.nih.gov/35412612/#affiliation-6 "Saw Swee Hock School of Public Health, National University of Singapore, Singapore.") ### Affiliations - 1 Ministry of Health, Singapore. - 2 National Centre for Infectious Diseases, Singapore. - 3 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. - 4 Yong Loo Lin School of Medicine, National University of Singapore, Singapore. - 5 Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore. - 6 Saw Swee Hock School of Public Health, National University of Singapore, Singapore. - PMID: [35412612](https://pubmed.ncbi.nlm.nih.gov/35412612/) - PMCID: [PMC9047219](https://pmc.ncbi.nlm.nih.gov/articles/PMC9047219/) - DOI: [10\.1093/cid/ciac288](https://doi.org/10.1093/cid/ciac288) ## Abstract Compared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29-2.46) and 1.62 (95% CI, 1.43-1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.42 (95% CI, 0.25-0.70) times less likely to develop severe disease. **Keywords:** COVID-19; SARS-CoV-2; inactivated vaccine; mRNA vaccine; vaccines. © The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. ## MeSH terms - COVID-19 Vaccines - COVID-19\* / prevention & control - Humans - RNA, Messenger - Singapore / epidemiology - Vaccines, Inactivated ## Substances - COVID-19 Vaccines - RNA, Messenger - Vaccines, Inactivated
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