🕷️ Crawler Inspector

URL Lookup

Direct Parameter Lookup

Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 143 (from laksa135)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa143.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical, ml_categories_json AS ml_categories_json, ml_types_json AS ml_types_json, ml_intent_types_json AS ml_intent_types_json, meta_language AS meta_language, attrs_author AS attrs_author, ifNull(toUnixTimestamp(attrs_publish_time), 0) AS attrs_publish_time, ifNull(toUnixTimestamp(attrs_original_publish_time), 0) AS attrs_original_publish_time, ifNull(attrs_is_republished, 0) AS attrs_is_republished, ifNull(attrs_nr_words, 0) AS attrs_nr_words, ifNull(attrs_boilerpipe_nr_words, 0) AS attrs_boilerpipe_nr_words, ifNull(body_ext_links_number, 0) AS body_ext_links_number, ifNull(body_int_links_number, 0) AS body_int_links_number, ifNull(meta_nofollow, 0) AS meta_nofollow, ifNull(meta_noarchive, 0) AS meta_noarchive, ifNull(props_was_rendered, 0) AS props_was_rendered, ifNull(src_redirect, \'\') AS src_redirect, ifNull(download_time_msec, 0) AS download_time_msec, ifNull(download_ttfb_msec, 0) AS download_ttfb_msec, ifNull(download_size, 0) AS download_size FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://my.clevelandclinic.org/health/treatments/24795-ssri\')), getAhrefsUnparsedNoserviceFromURL(\'https://my.clevelandclinic.org/health/treatments/24795-ssri\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/my.clevelandclinic.org\/health\/treatments\/24795-ssri","crawl_time":1776646871,"first_indexed_time":1678303204,"http_code":200,"src_unparsed":"org,clevelandclinic!my,\/health\/treatments\/24795-ssri s443","src_root_hash":"9889140825964526943","history_drop_reason":null,"meta_title":"Selective Serotonin Reuptake Inhibitors: Uses & Side Effects","meta_descriptions":["SSRIs (selective serotonin reuptake inhibitors) are a class of antidepressants. They help treat depression and anxiety, among other conditions."],"attrs_boilerpipe_text":"What are the potential benefits of SSRIs?\nThese medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with\ntalk therapy\n, like\ncognitive behavioral therapy\n(CBT). SSRIs are generally well tolerated, with mild or minimal side effects.\nSSRI side effects\nCommon side effects may include:\nEach medication has different side effects. Ask your provider or\npharmacist\nfor more information.\nRisks and complications of SSRIs\nWhile these medications are generally safe, they may cause rare but serious complications in some cases, such as:\nAntidepressant discontinuation syndrome\n: Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose.\nQT prolongation\n: A problem with your\nheart’s\nelectrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening.\nSerotonin syndrome\n: This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and\/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms.\nSuicidal thoughts\n: People under 25 may be at higher risk of developing or having worsening suicidal thoughts.\nIf you’re thinking about\nsuicide\n, you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24\/7.\nWhat interacts with SSRIs?\nSome medications may interact with SSRIs, including:\nBlood clot-preventing medication (low-dose\naspirin\n,\nclopidogrel\n)\nHerbal supplements (\nSt. John’s wort\n)\nCertain migraine medicines (\ntriptans\n)\nNSAIDs\n(\nibuprofen\n,\ndiclofenac\n,\nnaproxen\n)\nOver-the-counter cough suppressants (like\ndextromethorphan\n)\nOther antidepressants\nThis isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms.\nCan I drink alcohol while on an SSRI?\nIt’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider.\nCan I take SSRIs if I’m pregnant or thinking of becoming pregnant?\nSSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best.\nStopping treatment with SSRIs\nIf you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer.\nHow long does it take for an SSRI to work?\nSelective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. If you’re not feeling better by then, check in with your provider, who may recommend an adjustment to your treatment plan.","attrs_markdown":"![](https:\/\/zdbb.net\/l\/Dnl1wmWs8xCCpvWNCt9Egf\/?w=16&q=75)\n\nLocations:\n\n[Abu Dhabi](https:\/\/www.clevelandclinicabudhabi.ae\/en)\\|[Canada](https:\/\/my.clevelandclinic.org\/canada)\\|[Florida](https:\/\/my.clevelandclinic.org\/florida)\\|[London](https:\/\/clevelandcliniclondon.uk\/)\\|[Nevada](https:\/\/my.clevelandclinic.org\/locations\/nevada)\\|[Ohio](https:\/\/my.clevelandclinic.org\/)\\|\n\n![Gray gradient](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/gray-gradient-left-16.59910877.svg?w=32&q=75)![Gray gradient](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/gray-gradient-right-32.dd7ce4e5.svg?w=64&q=75)\n\n[855\\.733.3712](tel:8557333712)\\|[MyChart](https:\/\/my.clevelandclinic.org\/online-services\/mychart)\\|[Need Help?](https:\/\/my.clevelandclinic.org\/help)\\|[Careers](https:\/\/jobs.clevelandclinic.org\/)\\|[Donate Now](https:\/\/give.ccf.org\/give\/187824#!\/donation\/checkout)\\|\n\n![Gray gradient](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/gray-gradient-left-16.59910877.svg?w=32&q=75)![Gray gradient](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/gray-gradient-right-32.dd7ce4e5.svg?w=64&q=75)\n\n[![Cleveland Clinic logo](https:\/\/assets.clevelandclinic.org\/transform\/1bc1ff31-3cbc-4976-9ddf-9bc85e0877eb\/Cleveland-Clinic-Logo-Web?w=3840&q=75)](https:\/\/my.clevelandclinic.org\/)\n\n[Find a Provider](https:\/\/my.clevelandclinic.org\/providers)[Locations and Directions](https:\/\/my.clevelandclinic.org\/locations)[Services](https:\/\/my.clevelandclinic.org\/services)[Patients and Visitors](https:\/\/my.clevelandclinic.org\/patients)[Health Library](https:\/\/my.clevelandclinic.org\/health)\n\n- [Find a Provider](https:\/\/my.clevelandclinic.org\/providers)\n- [Locations and Directions](https:\/\/my.clevelandclinic.org\/locations)\n- [Services](https:\/\/my.clevelandclinic.org\/services)\n- [Patients and Visitors](https:\/\/my.clevelandclinic.org\/patients)\n- [Health Library](https:\/\/my.clevelandclinic.org\/health)\n\n[![Search](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/LondonGreenSearchIcon.6d7e718f.svg?w=64&q=75)](https:\/\/my.clevelandclinic.org\/search)\n\nMenu\n\n[![Search](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/LondonGreenSearchIcon.6d7e718f.svg?w=64&q=75)](https:\/\/my.clevelandclinic.org\/search)[Appointments](https:\/\/my.clevelandclinic.org\/patients\/information\/access)\n\n[Home](https:\/\/my.clevelandclinic.org\/)\/\n\n[Health Library](https:\/\/my.clevelandclinic.org\/health)\/\n\n[Medical Treatments](https:\/\/my.clevelandclinic.org\/health\/treatments)\/\n\nSSRIs (Selective Serotonin Reuptake Inhibitors)\n\nAdvertisement\n\nAdvertisement\n# SSRIs (Selective Serotonin Reuptake Inhibitors)\nMedically Reviewed.\n\nLast updated on 09\/26\/2025.\n\nSSRIs (selective serotonin reuptake inhibitors) are FDA-approved antidepressant medications. They help treat several conditions like depression, anxiety and bulimia. They work by keeping a chemical messenger active in your brain. SSRIs are the most commonly prescribed type of antidepressant.\n\nAdvertisement\n\nCleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https:\/\/health.clevelandclinic.org\/advertising)\n\nCare at Cleveland Clinic\n\n[Anxiety Disorders Treatment](https:\/\/my.clevelandclinic.org\/services\/anxiety-disorders-treatment)\n\n[Find a Doctor and Specialists](https:\/\/my.clevelandclinic.org\/services\/anxiety-disorders-treatment#featured-provider-panel)\n\n[Make an Appointment](https:\/\/my.clevelandclinic.org\/webappointment\/what-to-expect)\n\nContents\n\n[What Are SSRIs?](https:\/\/my.clevelandclinic.org\/health\/treatments\/24795-ssri#what-are-ssris)[Risks \/ Benefits](https:\/\/my.clevelandclinic.org\/health\/treatments\/24795-ssri#risks-benefits)\n\nContents\n\n[What Are SSRIs?](https:\/\/my.clevelandclinic.org\/health\/treatments\/24795-ssri#what-are-ssris)[Risks \/ Benefits](https:\/\/my.clevelandclinic.org\/health\/treatments\/24795-ssri#risks-benefits)\n\n## What Are SSRIs?\nSSRIs (selective serotonin reuptake inhibitors) are a common type of antidepressant. They work by changing the activity of serotonin, a chemical that affects your mood, as well as many other bodily and mental functions.\n\nAdvertisement\n\nCleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https:\/\/health.clevelandclinic.org\/advertising)\n\nThese medications are often used to treat [mental health conditions](https:\/\/my.clevelandclinic.org\/health\/diseases\/22295-mental-health-disorders), like depression, anxiety, PTSD and OCD. They can also help manage other conditions and symptoms.\n\nThere are several types of antidepressants, but SSRIs are usually the first choice by healthcare providers. That’s because they tend to cause fewer and milder side effects compared to other options.\n\n### Types of SSRI drugs\nSelective serotonin reuptake inhibitors that providers currently prescribe in the United States include:\n\n- [Citalopram](https:\/\/my.clevelandclinic.org\/health\/drugs\/18726-citalopram-tablets) (Celexa®)\n- [Escitalopram](https:\/\/my.clevelandclinic.org\/health\/drugs\/18917-escitalopram-tablets) (Lexapro®)\n- [Fluoxetine](https:\/\/my.clevelandclinic.org\/health\/drugs\/20119-fluoxetine-capsules-or-tablets-depressionmood-disorders) (Prozac®, Sarafem™)\n- [Fluvoxamine](https:\/\/my.clevelandclinic.org\/health\/drugs\/19625-fluvoxamine-tablets) (Luvox®)\n- [Paroxetine](https:\/\/my.clevelandclinic.org\/health\/drugs\/19762-paroxetine-tablets) (Brisdelle™, Paxil™, Pexeva®)\n- [Sertraline](https:\/\/my.clevelandclinic.org\/health\/drugs\/20089-sertraline-tablets) (Zoloft®)\n- [Vilazodone](https:\/\/my.clevelandclinic.org\/health\/drugs\/20831-vilazodone-tablets) (Viibryd®)\n- [Vortioxetine](https:\/\/my.clevelandclinic.org\/health\/drugs\/19369-vortioxetine-tablets) (Trintillex®)\n### What are SSRIs approved for?\nThe U.S. Food and Drug Administration (FDA) has approved SSRIs to treat the following conditions:\n\n- [Major depressive disorder (MDD)](https:\/\/my.clevelandclinic.org\/health\/diseases\/24481-clinical-depression-major-depressive-disorder)\n- [Generalized anxiety disorder (GAD)](https:\/\/my.clevelandclinic.org\/health\/diseases\/23940-generalized-anxiety-disorder-gad)\n- [Bulimia nervosa](https:\/\/my.clevelandclinic.org\/health\/diseases\/9795-bulimia-nervosa)\n- [Menopause](https:\/\/my.clevelandclinic.org\/health\/diseases\/21841-menopause)\n- [Obsessive-compulsive disorder (OCD)](https:\/\/my.clevelandclinic.org\/health\/diseases\/9490-obsessive-compulsive-disorder)\n- [Panic disorder](https:\/\/my.clevelandclinic.org\/health\/diseases\/4451-panic-disorder)\n- [Premenstrual dysphoric disorder (PMDD)](https:\/\/my.clevelandclinic.org\/health\/articles\/9132-premenstrual-dysphoric-disorder-pmdd)\n- [Post-traumatic stress disorder (PTSD)](https:\/\/my.clevelandclinic.org\/health\/diseases\/9545-post-traumatic-stress-disorder-ptsd)\n- [Social anxiety disorder](https:\/\/my.clevelandclinic.org\/health\/diseases\/22709-social-anxiety) (social phobia)\n\nHealthcare providers sometimes use SSRIs to help with other conditions, too. This is an off-label use. Examples may include:\n\n- [Binge eating disorder](https:\/\/my.clevelandclinic.org\/health\/diseases\/17652-binge-eating-disorder)\n- [Body dysmorphic disorder](https:\/\/my.clevelandclinic.org\/health\/diseases\/9888-body-dysmorphic-disorder)\n- Chronic [pelvic pain](https:\/\/my.clevelandclinic.org\/health\/symptoms\/12106-pelvic-pain) syndrome\n- [Fibromyalgia](https:\/\/my.clevelandclinic.org\/health\/diseases\/4832-fibromyalgia)\n- [Premature ejaculation](https:\/\/my.clevelandclinic.org\/health\/diseases\/15627-premature-ejaculation)\n\nAdvertisement\n\n### How do SSRI antidepressants work?\nSerotonin is a type of [neurotransmitter](https:\/\/my.clevelandclinic.org\/health\/articles\/22513-neurotransmitters), or chemical messenger. Neurotransmitters are molecules that dictate how different regions of your brain communicate with each other. Normally, after serotonin delivers its message, your brain cells reabsorb it. This is a process called reuptake. SSRIs block this reabsorption, allowing serotonin to remain active in your brain for a longer period of time. Serotonin plays a role in the regulation of:\n\n- Appetite\n- [Memory](https:\/\/my.clevelandclinic.org\/health\/articles\/memory)\n- Mood\n- Libido\n- Sleep\n- Social behavior\n\n## Risks \/ Benefits\n![Possible side effects of SSRIs](https:\/\/my.clevelandclinic.org\/-\/scassets\/images\/org\/health\/articles\/selective-serotonin-reuptake-inhibitors)\n\n**Image content:** This image is available to view online.\n\nView image online (https:\/\/my.clevelandclinic.org\/-\/scassets\/images\/org\/health\/articles\/selective-serotonin-reuptake-inhibitors)\n\nYour provider or pharmacist can give you more information about what SSRI side effects to look our for.\n\n### What are the potential benefits of SSRIs?\nThese medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with [talk therapy](https:\/\/my.clevelandclinic.org\/health\/treatments\/23445-psychotherapy), like [cognitive behavioral therapy](https:\/\/my.clevelandclinic.org\/health\/treatments\/21208-cognitive-behavioral-therapy-cbt) (CBT). SSRIs are generally well tolerated, with mild or minimal side effects.\n\n### SSRI side effects\nCommon side effects may include:\n\n- [Dizziness](https:\/\/my.clevelandclinic.org\/health\/symptoms\/6422-dizziness)\n- [Dry mouth](https:\/\/my.clevelandclinic.org\/health\/symptoms\/10902-dry-mouth-xerostomia)\n- Headache\n- Gastrointestinal distress\n- [Sexual dysfunction](https:\/\/my.clevelandclinic.org\/health\/diseases\/9121-sexual-dysfunction)\n- [Sleep disturbances](https:\/\/my.clevelandclinic.org\/health\/diseases\/11429-sleep-disorders)\n- Weight gain\n\nEach medication has different side effects. Ask your provider or [pharmacist](https:\/\/my.clevelandclinic.org\/health\/articles\/24786-pharmacist) for more information.\n\n#### Risks and complications of SSRIs\nWhile these medications are generally safe, they may cause rare but serious complications in some cases, such as:\n\n- [**Antidepressant discontinuation syndrome**](https:\/\/my.clevelandclinic.org\/health\/diseases\/25218-antidepressant-discontinuation-syndrome): Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose.\n- **QT prolongation**: A problem with your [heart’s](https:\/\/my.clevelandclinic.org\/health\/body\/21704-heart) electrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening.\n- [**Serotonin syndrome**](https:\/\/my.clevelandclinic.org\/health\/diseases\/17687-serotonin-syndrome): This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and\/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms.\n- [**Suicidal thoughts**](https:\/\/my.clevelandclinic.org\/health\/symptoms\/suicidal-ideation): People under 25 may be at higher risk of developing or having worsening suicidal thoughts.\n\nIf you’re thinking about [suicide](https:\/\/my.clevelandclinic.org\/health\/articles\/suicide), you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24\/7.\n\n#### What interacts with SSRIs?\nSome medications may interact with SSRIs, including:\n\n- Blood clot-preventing medication (low-dose [aspirin](https:\/\/my.clevelandclinic.org\/health\/drugs\/20592-aspirin-tablets), [clopidogrel](https:\/\/my.clevelandclinic.org\/health\/drugs\/20743-clopidogrel-tablets))\n- Herbal supplements ([St. John’s wort](https:\/\/my.clevelandclinic.org\/health\/drugs\/9304-st--johns-wort))\n- Certain migraine medicines ([triptans](https:\/\/my.clevelandclinic.org\/health\/treatments\/24998-triptans))\n- [NSAIDs](https:\/\/my.clevelandclinic.org\/health\/treatments\/11086-non-steroidal-anti-inflammatory-medicines-nsaids) ([ibuprofen](https:\/\/my.clevelandclinic.org\/health\/drugs\/20168-ibuprofen-capsules-or-tablets), [diclofenac](https:\/\/my.clevelandclinic.org\/health\/drugs\/18737-diclofenac-extended-release-tablets), [naproxen](https:\/\/my.clevelandclinic.org\/health\/drugs\/19747-naproxen-immediate-release-tablets))\n- Over-the-counter cough suppressants (like [dextromethorphan](https:\/\/my.clevelandclinic.org\/health\/drugs\/20631-dextromethorphan-solution))\n- Other antidepressants\n\nThis isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms.\n\n#### Can I drink alcohol while on an SSRI?\nIt’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider.\n\n#### Can I take SSRIs if I’m pregnant or thinking of becoming pregnant?\nSSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best.\n\nAdvertisement\n\n#### Stopping treatment with SSRIs\nIf you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer.\n\n### How long does it take for an SSRI to work?\nSelective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. If you’re not feeling better by then, check in with your provider, who may recommend an adjustment to your treatment plan.\n### A note from Cleveland Clinic\nTaking an antidepressant like an SSRI (selective serotonin reuptake inhibitor) isn’t a sign of personal weakness. These medications are widely used and can make a big difference, both mentally and physically. They can manage conditions beyond depression and anxiety to help you get back to feeling like yourself.\n\nIt’s normal to have questions when your provider recommends starting an SSRI. Don’t hesitate to speak up. Your provider can guide you through the process and make sure your treatment plan works well for you.\n\nAdvertisement\n\n[![Cleveland Clinic logo](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/logo-ccf.1e52a22b.svg?w=3840&q=75)](https:\/\/my.clevelandclinic.org\/)[![Cleveland Clinic icon](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/CCFLogo.000428c6.svg?w=3840&q=75)](https:\/\/my.clevelandclinic.org\/)\n\n[![Health Essentials logo](https:\/\/my.clevelandclinic.org\/_next\/static\/media\/HealthEssentials.b811bb06.svg?w=3840&q=75)](https:\/\/health.clevelandclinic.org\/)\n\n![Subscription icon](https:\/\/assets.clevelandclinic.org\/transform\/482db8cd-aa1e-45b5-a2a4-cf6aa5e5d2d4\/Health-Essentials?w=256&q=75)\n\n## Better health starts here\nSign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more.\n\n[Example email](https:\/\/assets.clevelandclinic.org\/transform\/2ff943a2-abb1-4a1c-8ede-f8848703e789\/HealthEssentials-SampleEmail-2026)[Sign up](https:\/\/my.clevelandclinic.org\/health-essentials-sign-up)\n\n[Sign up](https:\/\/my.clevelandclinic.org\/health-essentials-sign-up)[Example email](https:\/\/assets.clevelandclinic.org\/transform\/2ff943a2-abb1-4a1c-8ede-f8848703e789\/HealthEssentials-SampleEmail-2026)\n\n### Experts You Can Trust\nMedically Reviewed.\n\nLast updated on 09\/26\/2025.\n\nLearn more about the [Health Library](https:\/\/my.clevelandclinic.org\/health\/about) and our [editorial process](https:\/\/my.clevelandclinic.org\/about\/website\/editorial-policy).\n\n### References\nCleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards.\n#### View Sources\n\n### Experts You Can Trust\nMedically Reviewed.\n\nLast updated on 09\/26\/2025.\n\n### References\nCleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards.\n\n- Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors *(https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK554406\/)*. 2023 May 1. In: *StatPearls* \\[Internet\\]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Accessed 9\/26\/2025.\n- National Health Service (U.K.). Cautions - Selective serotonin reuptake inhibitors (SSRIs) *(https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/considerations\/)*. Last reviewed 12\/8\/2021. Accessed 9\/26\/2025.\n- National Health Service (U.K.). Overview – Selective Serotonin Reuptake Inhibitors (SSRIs) *(https:\/\/www.nhs.uk\/mental-health\/talking-therapies-medicine-treatments\/medicines-and-psychiatry\/ssri-antidepressants\/overview\/)*. Last reviewed 12\/8\/2021. Accessed 9\/26\/2025.\n- Skånland SS, Cieślar-Pobuda A. Off-Label Uses of Drugs for Depression *(https:\/\/pubmed.ncbi.nlm.nih.gov\/31622593\/)*. *Eur J Pharmacol.* 2019 Dec:865;172732. Accessed 9\/26\/2025.\n\n### Care at Cleveland Clinic\nAnxiety disorders can affect your life in many ways. Cleveland Clinic mental health experts can help you manage anxiety so you’re back in control.\n\n![Cleveland Clinic doctor consulting a patient.](https:\/\/my.clevelandclinic.org\/-\/scassets\/images\/org\/care-pages\/neuro\/anxiety-disorders-feature.jpg?w=640&q=75)\n\n[Anxiety Disorders Treatment](https:\/\/my.clevelandclinic.org\/services\/anxiety-disorders-treatment)\n\n[Find a Doctor and Specialists](https:\/\/my.clevelandclinic.org\/services\/anxiety-disorders-treatment#featured-provider-panel)\n\n[Make an Appointment](https:\/\/my.clevelandclinic.org\/webappointment\/what-to-expect)\n\nAdvertisement\n\nAdvertisement\n\nAd\n\nAppointments [866\\.588.2264](tel:8665882264)\n\n[Appointments & Locations](https:\/\/my.clevelandclinic.org\/departments\/neurological\/appointments)\n\n[Request an Appointment](https:\/\/my.clevelandclinic.org\/webappointment\/what-to-expect)\n\n[Find a ProviderNeed a primary care doctor or a specialist? 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All Rights Reserved.","attrs_readable_markdown":"### What are the potential benefits of SSRIs?\nThese medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with [talk therapy](https:\/\/my.clevelandclinic.org\/health\/treatments\/23445-psychotherapy), like [cognitive behavioral therapy](https:\/\/my.clevelandclinic.org\/health\/treatments\/21208-cognitive-behavioral-therapy-cbt) (CBT). SSRIs are generally well tolerated, with mild or minimal side effects.\n\n### SSRI side effects\nCommon side effects may include:\n\nEach medication has different side effects. Ask your provider or [pharmacist](https:\/\/my.clevelandclinic.org\/health\/articles\/24786-pharmacist) for more information.\n\n#### Risks and complications of SSRIs\nWhile these medications are generally safe, they may cause rare but serious complications in some cases, such as:\n\n- [**Antidepressant discontinuation syndrome**](https:\/\/my.clevelandclinic.org\/health\/diseases\/25218-antidepressant-discontinuation-syndrome): Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose.\n- **QT prolongation**: A problem with your [heart’s](https:\/\/my.clevelandclinic.org\/health\/body\/21704-heart) electrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening.\n- [**Serotonin syndrome**](https:\/\/my.clevelandclinic.org\/health\/diseases\/17687-serotonin-syndrome): This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and\/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms.\n- [**Suicidal thoughts**](https:\/\/my.clevelandclinic.org\/health\/symptoms\/suicidal-ideation): People under 25 may be at higher risk of developing or having worsening suicidal thoughts.\n\nIf you’re thinking about [suicide](https:\/\/my.clevelandclinic.org\/health\/articles\/suicide), you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24\/7.\n\n#### What interacts with SSRIs?\nSome medications may interact with SSRIs, including:\n\n- Blood clot-preventing medication (low-dose [aspirin](https:\/\/my.clevelandclinic.org\/health\/drugs\/20592-aspirin-tablets), [clopidogrel](https:\/\/my.clevelandclinic.org\/health\/drugs\/20743-clopidogrel-tablets))\n- Herbal supplements ([St. John’s wort](https:\/\/my.clevelandclinic.org\/health\/drugs\/9304-st--johns-wort))\n- Certain migraine medicines ([triptans](https:\/\/my.clevelandclinic.org\/health\/treatments\/24998-triptans))\n- [NSAIDs](https:\/\/my.clevelandclinic.org\/health\/treatments\/11086-non-steroidal-anti-inflammatory-medicines-nsaids) ([ibuprofen](https:\/\/my.clevelandclinic.org\/health\/drugs\/20168-ibuprofen-capsules-or-tablets), [diclofenac](https:\/\/my.clevelandclinic.org\/health\/drugs\/18737-diclofenac-extended-release-tablets), [naproxen](https:\/\/my.clevelandclinic.org\/health\/drugs\/19747-naproxen-immediate-release-tablets))\n- Over-the-counter cough suppressants (like [dextromethorphan](https:\/\/my.clevelandclinic.org\/health\/drugs\/20631-dextromethorphan-solution))\n- Other antidepressants\n\nThis isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms.\n\n#### Can I drink alcohol while on an SSRI?\nIt’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider.\n\n#### Can I take SSRIs if I’m pregnant or thinking of becoming pregnant?\nSSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best.\n\n#### Stopping treatment with SSRIs\nIf you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer.\n\n### How long does it take for an SSRI to work?\nSelective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. 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Selective Serotonin Reuptake Inhibitors: Uses & Side Effects

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SSRIs (selective serotonin reuptake inhibitors) are a class of antidepressants. They help treat depression and anxiety, among other conditions.

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What are the potential benefits of SSRIs? These medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with talk therapy , like cognitive behavioral therapy (CBT). SSRIs are generally well tolerated, with mild or minimal side effects. SSRI side effects Common side effects may include: Each medication has different side effects. Ask your provider or pharmacist for more information. Risks and complications of SSRIs While these medications are generally safe, they may cause rare but serious complications in some cases, such as: Antidepressant discontinuation syndrome : Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose. QT prolongation : A problem with your heart’s electrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening. Serotonin syndrome : This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms. Suicidal thoughts : People under 25 may be at higher risk of developing or having worsening suicidal thoughts. If you’re thinking about suicide , you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24/7. What interacts with SSRIs? Some medications may interact with SSRIs, including: Blood clot-preventing medication (low-dose aspirin , clopidogrel ) Herbal supplements ( St. John’s wort ) Certain migraine medicines ( triptans ) NSAIDs ( ibuprofen , diclofenac , naproxen ) Over-the-counter cough suppressants (like dextromethorphan ) Other antidepressants This isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms. Can I drink alcohol while on an SSRI? It’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider. Can I take SSRIs if I’m pregnant or thinking of becoming pregnant? SSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best. Stopping treatment with SSRIs If you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer. How long does it take for an SSRI to work? Selective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. If you’re not feeling better by then, check in with your provider, who may recommend an adjustment to your treatment plan.

Markdown

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Last updated on 09/26/2025. SSRIs (selective serotonin reuptake inhibitors) are FDA-approved antidepressant medications. They help treat several conditions like depression, anxiety and bulimia. They work by keeping a chemical messenger active in your brain. SSRIs are the most commonly prescribed type of antidepressant. Advertisement Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https://health.clevelandclinic.org/advertising) Care at Cleveland Clinic [Anxiety Disorders Treatment](https://my.clevelandclinic.org/services/anxiety-disorders-treatment) [Find a Doctor and Specialists](https://my.clevelandclinic.org/services/anxiety-disorders-treatment#featured-provider-panel) [Make an Appointment](https://my.clevelandclinic.org/webappointment/what-to-expect) Contents [What Are SSRIs?](https://my.clevelandclinic.org/health/treatments/24795-ssri#what-are-ssris)[Risks / Benefits](https://my.clevelandclinic.org/health/treatments/24795-ssri#risks-benefits) Contents [What Are SSRIs?](https://my.clevelandclinic.org/health/treatments/24795-ssri#what-are-ssris)[Risks / Benefits](https://my.clevelandclinic.org/health/treatments/24795-ssri#risks-benefits) ## What Are SSRIs? SSRIs (selective serotonin reuptake inhibitors) are a common type of antidepressant. They work by changing the activity of serotonin, a chemical that affects your mood, as well as many other bodily and mental functions. Advertisement Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https://health.clevelandclinic.org/advertising) These medications are often used to treat [mental health conditions](https://my.clevelandclinic.org/health/diseases/22295-mental-health-disorders), like depression, anxiety, PTSD and OCD. They can also help manage other conditions and symptoms. There are several types of antidepressants, but SSRIs are usually the first choice by healthcare providers. That’s because they tend to cause fewer and milder side effects compared to other options. ### Types of SSRI drugs Selective serotonin reuptake inhibitors that providers currently prescribe in the United States include: - [Citalopram](https://my.clevelandclinic.org/health/drugs/18726-citalopram-tablets) (Celexa®) - [Escitalopram](https://my.clevelandclinic.org/health/drugs/18917-escitalopram-tablets) (Lexapro®) - [Fluoxetine](https://my.clevelandclinic.org/health/drugs/20119-fluoxetine-capsules-or-tablets-depressionmood-disorders) (Prozac®, Sarafem™) - [Fluvoxamine](https://my.clevelandclinic.org/health/drugs/19625-fluvoxamine-tablets) (Luvox®) - [Paroxetine](https://my.clevelandclinic.org/health/drugs/19762-paroxetine-tablets) (Brisdelle™, Paxil™, Pexeva®) - [Sertraline](https://my.clevelandclinic.org/health/drugs/20089-sertraline-tablets) (Zoloft®) - [Vilazodone](https://my.clevelandclinic.org/health/drugs/20831-vilazodone-tablets) (Viibryd®) - [Vortioxetine](https://my.clevelandclinic.org/health/drugs/19369-vortioxetine-tablets) (Trintillex®) ### What are SSRIs approved for? The U.S. Food and Drug Administration (FDA) has approved SSRIs to treat the following conditions: - [Major depressive disorder (MDD)](https://my.clevelandclinic.org/health/diseases/24481-clinical-depression-major-depressive-disorder) - [Generalized anxiety disorder (GAD)](https://my.clevelandclinic.org/health/diseases/23940-generalized-anxiety-disorder-gad) - [Bulimia nervosa](https://my.clevelandclinic.org/health/diseases/9795-bulimia-nervosa) - [Menopause](https://my.clevelandclinic.org/health/diseases/21841-menopause) - [Obsessive-compulsive disorder (OCD)](https://my.clevelandclinic.org/health/diseases/9490-obsessive-compulsive-disorder) - [Panic disorder](https://my.clevelandclinic.org/health/diseases/4451-panic-disorder) - [Premenstrual dysphoric disorder (PMDD)](https://my.clevelandclinic.org/health/articles/9132-premenstrual-dysphoric-disorder-pmdd) - [Post-traumatic stress disorder (PTSD)](https://my.clevelandclinic.org/health/diseases/9545-post-traumatic-stress-disorder-ptsd) - [Social anxiety disorder](https://my.clevelandclinic.org/health/diseases/22709-social-anxiety) (social phobia) Healthcare providers sometimes use SSRIs to help with other conditions, too. This is an off-label use. Examples may include: - [Binge eating disorder](https://my.clevelandclinic.org/health/diseases/17652-binge-eating-disorder) - [Body dysmorphic disorder](https://my.clevelandclinic.org/health/diseases/9888-body-dysmorphic-disorder) - Chronic [pelvic pain](https://my.clevelandclinic.org/health/symptoms/12106-pelvic-pain) syndrome - [Fibromyalgia](https://my.clevelandclinic.org/health/diseases/4832-fibromyalgia) - [Premature ejaculation](https://my.clevelandclinic.org/health/diseases/15627-premature-ejaculation) Advertisement ### How do SSRI antidepressants work? Serotonin is a type of [neurotransmitter](https://my.clevelandclinic.org/health/articles/22513-neurotransmitters), or chemical messenger. Neurotransmitters are molecules that dictate how different regions of your brain communicate with each other. Normally, after serotonin delivers its message, your brain cells reabsorb it. This is a process called reuptake. SSRIs block this reabsorption, allowing serotonin to remain active in your brain for a longer period of time. Serotonin plays a role in the regulation of: - Appetite - [Memory](https://my.clevelandclinic.org/health/articles/memory) - Mood - Libido - Sleep - Social behavior ## Risks / Benefits ![Possible side effects of SSRIs](https://my.clevelandclinic.org/-/scassets/images/org/health/articles/selective-serotonin-reuptake-inhibitors) **Image content:** This image is available to view online. View image online (https://my.clevelandclinic.org/-/scassets/images/org/health/articles/selective-serotonin-reuptake-inhibitors) Your provider or pharmacist can give you more information about what SSRI side effects to look our for. ### What are the potential benefits of SSRIs? These medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with [talk therapy](https://my.clevelandclinic.org/health/treatments/23445-psychotherapy), like [cognitive behavioral therapy](https://my.clevelandclinic.org/health/treatments/21208-cognitive-behavioral-therapy-cbt) (CBT). SSRIs are generally well tolerated, with mild or minimal side effects. ### SSRI side effects Common side effects may include: - [Dizziness](https://my.clevelandclinic.org/health/symptoms/6422-dizziness) - [Dry mouth](https://my.clevelandclinic.org/health/symptoms/10902-dry-mouth-xerostomia) - Headache - Gastrointestinal distress - [Sexual dysfunction](https://my.clevelandclinic.org/health/diseases/9121-sexual-dysfunction) - [Sleep disturbances](https://my.clevelandclinic.org/health/diseases/11429-sleep-disorders) - Weight gain Each medication has different side effects. Ask your provider or [pharmacist](https://my.clevelandclinic.org/health/articles/24786-pharmacist) for more information. #### Risks and complications of SSRIs While these medications are generally safe, they may cause rare but serious complications in some cases, such as: - [**Antidepressant discontinuation syndrome**](https://my.clevelandclinic.org/health/diseases/25218-antidepressant-discontinuation-syndrome): Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose. - **QT prolongation**: A problem with your [heart’s](https://my.clevelandclinic.org/health/body/21704-heart) electrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening. - [**Serotonin syndrome**](https://my.clevelandclinic.org/health/diseases/17687-serotonin-syndrome): This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms. - [**Suicidal thoughts**](https://my.clevelandclinic.org/health/symptoms/suicidal-ideation): People under 25 may be at higher risk of developing or having worsening suicidal thoughts. If you’re thinking about [suicide](https://my.clevelandclinic.org/health/articles/suicide), you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24/7. #### What interacts with SSRIs? Some medications may interact with SSRIs, including: - Blood clot-preventing medication (low-dose [aspirin](https://my.clevelandclinic.org/health/drugs/20592-aspirin-tablets), [clopidogrel](https://my.clevelandclinic.org/health/drugs/20743-clopidogrel-tablets)) - Herbal supplements ([St. John’s wort](https://my.clevelandclinic.org/health/drugs/9304-st--johns-wort)) - Certain migraine medicines ([triptans](https://my.clevelandclinic.org/health/treatments/24998-triptans)) - [NSAIDs](https://my.clevelandclinic.org/health/treatments/11086-non-steroidal-anti-inflammatory-medicines-nsaids) ([ibuprofen](https://my.clevelandclinic.org/health/drugs/20168-ibuprofen-capsules-or-tablets), [diclofenac](https://my.clevelandclinic.org/health/drugs/18737-diclofenac-extended-release-tablets), [naproxen](https://my.clevelandclinic.org/health/drugs/19747-naproxen-immediate-release-tablets)) - Over-the-counter cough suppressants (like [dextromethorphan](https://my.clevelandclinic.org/health/drugs/20631-dextromethorphan-solution)) - Other antidepressants This isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms. #### Can I drink alcohol while on an SSRI? It’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider. #### Can I take SSRIs if I’m pregnant or thinking of becoming pregnant? SSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best. Advertisement #### Stopping treatment with SSRIs If you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer. ### How long does it take for an SSRI to work? Selective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. If you’re not feeling better by then, check in with your provider, who may recommend an adjustment to your treatment plan. ### A note from Cleveland Clinic Taking an antidepressant like an SSRI (selective serotonin reuptake inhibitor) isn’t a sign of personal weakness. These medications are widely used and can make a big difference, both mentally and physically. They can manage conditions beyond depression and anxiety to help you get back to feeling like yourself. It’s normal to have questions when your provider recommends starting an SSRI. Don’t hesitate to speak up. Your provider can guide you through the process and make sure your treatment plan works well for you. Advertisement [![Cleveland Clinic logo](https://my.clevelandclinic.org/_next/static/media/logo-ccf.1e52a22b.svg?w=3840&q=75)](https://my.clevelandclinic.org/)[![Cleveland Clinic icon](https://my.clevelandclinic.org/_next/static/media/CCFLogo.000428c6.svg?w=3840&q=75)](https://my.clevelandclinic.org/) [![Health Essentials logo](https://my.clevelandclinic.org/_next/static/media/HealthEssentials.b811bb06.svg?w=3840&q=75)](https://health.clevelandclinic.org/) ![Subscription icon](https://assets.clevelandclinic.org/transform/482db8cd-aa1e-45b5-a2a4-cf6aa5e5d2d4/Health-Essentials?w=256&q=75) ## Better health starts here Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more. 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Last updated on 09/26/2025. ### References Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards. - Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors *(https://www.ncbi.nlm.nih.gov/books/NBK554406/)*. 2023 May 1. In: *StatPearls* \[Internet\]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Accessed 9/26/2025. - National Health Service (U.K.). Cautions - Selective serotonin reuptake inhibitors (SSRIs) *(https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/considerations/)*. Last reviewed 12/8/2021. Accessed 9/26/2025. - National Health Service (U.K.). Overview – Selective Serotonin Reuptake Inhibitors (SSRIs) *(https://www.nhs.uk/mental-health/talking-therapies-medicine-treatments/medicines-and-psychiatry/ssri-antidepressants/overview/)*. Last reviewed 12/8/2021. Accessed 9/26/2025. - Skånland SS, Cieślar-Pobuda A. Off-Label Uses of Drugs for Depression *(https://pubmed.ncbi.nlm.nih.gov/31622593/)*. *Eur J Pharmacol.* 2019 Dec:865;172732. Accessed 9/26/2025. ### Care at Cleveland Clinic Anxiety disorders can affect your life in many ways. 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Readable Markdown

### What are the potential benefits of SSRIs? These medications help manage symptoms of depression and anxiety, as well as many other conditions. These medications often work well when paired with [talk therapy](https://my.clevelandclinic.org/health/treatments/23445-psychotherapy), like [cognitive behavioral therapy](https://my.clevelandclinic.org/health/treatments/21208-cognitive-behavioral-therapy-cbt) (CBT). SSRIs are generally well tolerated, with mild or minimal side effects. ### SSRI side effects Common side effects may include: Each medication has different side effects. Ask your provider or [pharmacist](https://my.clevelandclinic.org/health/articles/24786-pharmacist) for more information. #### Risks and complications of SSRIs While these medications are generally safe, they may cause rare but serious complications in some cases, such as: - [**Antidepressant discontinuation syndrome**](https://my.clevelandclinic.org/health/diseases/25218-antidepressant-discontinuation-syndrome): Stopping your medication suddenly may lead to symptoms like dizziness, flu-like aches or anxiety. Always talk to your provider before making changes to your dose. - **QT prolongation**: A problem with your [heart’s](https://my.clevelandclinic.org/health/body/21704-heart) electrical system causes it to take too long to reset between beats. When untreated, a prolonged QT interval could be life-threatening. - [**Serotonin syndrome**](https://my.clevelandclinic.org/health/diseases/17687-serotonin-syndrome): This is when too much serotonin builds up in your body. Warning signs include confusion, a fast heart rate, fever and/or stiff muscles. Contact your doctor or go to the nearest emergency room if you have these symptoms. - [**Suicidal thoughts**](https://my.clevelandclinic.org/health/symptoms/suicidal-ideation): People under 25 may be at higher risk of developing or having worsening suicidal thoughts. If you’re thinking about [suicide](https://my.clevelandclinic.org/health/articles/suicide), you can reach out for help. Contact your provider. You can also call or text 988 (U.S.) to reach the Suicide and Crisis Lifeline. Someone is available to talk to you 24/7. #### What interacts with SSRIs? Some medications may interact with SSRIs, including: - Blood clot-preventing medication (low-dose [aspirin](https://my.clevelandclinic.org/health/drugs/20592-aspirin-tablets), [clopidogrel](https://my.clevelandclinic.org/health/drugs/20743-clopidogrel-tablets)) - Herbal supplements ([St. John’s wort](https://my.clevelandclinic.org/health/drugs/9304-st--johns-wort)) - Certain migraine medicines ([triptans](https://my.clevelandclinic.org/health/treatments/24998-triptans)) - [NSAIDs](https://my.clevelandclinic.org/health/treatments/11086-non-steroidal-anti-inflammatory-medicines-nsaids) ([ibuprofen](https://my.clevelandclinic.org/health/drugs/20168-ibuprofen-capsules-or-tablets), [diclofenac](https://my.clevelandclinic.org/health/drugs/18737-diclofenac-extended-release-tablets), [naproxen](https://my.clevelandclinic.org/health/drugs/19747-naproxen-immediate-release-tablets)) - Over-the-counter cough suppressants (like [dextromethorphan](https://my.clevelandclinic.org/health/drugs/20631-dextromethorphan-solution)) - Other antidepressants This isn’t a complete list. Talk to your healthcare provider about all the medications and supplements you currently take. They’ll let you know if an SSRI is the safest option to manage your symptoms. #### Can I drink alcohol while on an SSRI? It’s best to avoid alcohol while taking antidepressants, including SSRIs. Alcohol is a depressant and might interfere with how well the medication works. It can sometimes make depression symptoms worse. If you have concerns about drinking, talk to your provider. #### Can I take SSRIs if I’m pregnant or thinking of becoming pregnant? SSRIs have been shown to cause some negative effects in a developing fetus. However, stopping these medications during pregnancy also carries risks. Your depression symptoms may worsen without treatment. If you’re pregnant or planning to become pregnant, talk to your provider. They can explain the risks and benefits in detail and help you decide what’s best. #### Stopping treatment with SSRIs If you need or want to stop taking an SSRI, your provider will help you gradually reduce your dose. Quitting abruptly can lead to a group of symptoms known as antidepressant discontinuation syndrome. These symptoms typically happen if you’ve been on the medication for six weeks or longer. ### How long does it take for an SSRI to work? Selective serotonin reuptake inhibitors take time to work, usually between four and six weeks after reaching a therapeutic dose. But they can take even longer (between nine and 12 weeks) in certain individuals. If you’re not feeling better by then, check in with your provider, who may recommend an adjustment to your treatment plan.

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