🕷️ Crawler Inspector

 Locations: [Abu Dhabi](https://www.clevelandclinicabudhabi.ae/en)\|[Canada](https://my.clevelandclinic.org/canada)\|[Florida](https://my.clevelandclinic.org/florida)\|[London](https://clevelandcliniclondon.uk/)\|[Nevada](https://my.clevelandclinic.org/locations/nevada)\|[Ohio](https://my.clevelandclinic.org/)\|  [855\.733.3712](tel:8557333712)\|[MyChart](https://my.clevelandclinic.org/online-services/mychart)\|[Need Help?](https://my.clevelandclinic.org/help)\|[Careers](https://jobs.clevelandclinic.org/)\|[Donate Now](https://give.ccf.org/give/187824#!/donation/checkout)\|  [](https://my.clevelandclinic.org/) [Find a Provider](https://my.clevelandclinic.org/providers)[Locations and Directions](https://my.clevelandclinic.org/locations)[Services](https://my.clevelandclinic.org/services)[Patients and Visitors](https://my.clevelandclinic.org/patients)[Health Library](https://my.clevelandclinic.org/health) - [Find a Provider](https://my.clevelandclinic.org/providers) - [Locations and Directions](https://my.clevelandclinic.org/locations) - [Services](https://my.clevelandclinic.org/services) - [Patients and Visitors](https://my.clevelandclinic.org/patients) - [Health Library](https://my.clevelandclinic.org/health) [](https://my.clevelandclinic.org/search) Menu [](https://my.clevelandclinic.org/search)[Appointments](https://my.clevelandclinic.org/patients/information/access) [Home](https://my.clevelandclinic.org/)/ [Health Library](https://my.clevelandclinic.org/health)/ [Symptoms](https://my.clevelandclinic.org/health/symptoms)/ Fatigue Advertisement Advertisement # Fatigue Medically Reviewed. Last updated on 04/13/2023. The definition of fatigue is extreme tiredness. Severe fatigue makes it difficult for you to get up in the morning and make it through your day. Many conditions and lifestyle factors can cause fatigue. You may be able to relieve it by changing your habits. If an underlying condition causes it, a healthcare provider can usually help you manage it. Advertisement Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https://health.clevelandclinic.org/advertising) Care at Cleveland Clinic [Find a Primary Care Provider](https://my.clevelandclinic.org/services/primary-care) [Schedule an Appointment](https://my.clevelandclinic.org/services/primary-care#call-to-action-panel) Contents [Overview](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#overview)[Possible Causes](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#possible-causes)[Care and Treatment](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#care-and-treatment)[When To Call the Doctor](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#when-to-call-the-doctor) Contents [Overview](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#overview)[Possible Causes](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#possible-causes)[Care and Treatment](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#care-and-treatment)[When To Call the Doctor](https://my.clevelandclinic.org/health/symptoms/21206-fatigue#when-to-call-the-doctor) ## Overview ### What is fatigue? Everyone feels tired from time to time. But [fatigue](https://health.clevelandclinic.org/why-am-i-so-tired/) means feeling severely [overtired](https://health.clevelandclinic.org/overtired). Extreme fatigue makes it hard to get up in the morning, go to work, do your usual activities and make it through your day. Fatigue feels like you have an overwhelming urge to sleep, but you may not feel refreshed after you rest or sleep. Advertisement Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. [Policy](https://health.clevelandclinic.org/advertising) Fatigue often occurs along with other symptoms, such as: - [Depression](https://my.clevelandclinic.org/health/diseases/9290-depression) and lack of desire to do the activities you once enjoyed. - Trouble concentrating or focusing. - Very low energy and motivation. - Nervousness, [anxiety](https://my.clevelandclinic.org/health/diseases/9536-anxiety-disorders) and irritability. - [Muscle pain](https://my.clevelandclinic.org/health/symptoms/17669-muscle-pain) and weakness. Other fatigue symptoms include: - Tired eyes. - Tired legs. - Whole body tiredness. - Stiff shoulders. - Malaise (discomfort/uneasiness). - Boredom. - Impatience. ## Possible Causes ### What causes fatigue? Many conditions, disorders, medications and lifestyle factors can cause fatigue. Fatigue can be temporary, or it can be a chronic condition (lasting six months or more). You may be able to quickly fix fatigue by changing your diet, medications, exercise or sleep habits. If an underlying medical condition is causing your fatigue, a healthcare provider can usually treat the condition or help you manage it. Fatigue causes include: #### Lifestyle habits Certain lifestyle factors can contribute to fatigue. These factors may include: - Poor diet. - Excessive [alcohol use](https://my.clevelandclinic.org/health/diseases/3909-alcoholism). - Illegal drug use. - [Stress](https://my.clevelandclinic.org/health/articles/11874-stress). - [Burnout](https://health.clevelandclinic.org/work-stress-and-burnout/). - [Inactive (sedentary) lifestyle](https://health.clevelandclinic.org/sedentary-lifestyle). - [Jet lag](https://my.clevelandclinic.org/health/diseases/12781-jet-lag). #### Sleep disorders Certain sleep disorders can cause long-term exhaustion and extreme fatigue. These may include: - [Insomnia](https://my.clevelandclinic.org/health/diseases/12119-insomnia). - [Sleep apnea](https://my.clevelandclinic.org/health/diseases/8718-sleep-apnea). - [Narcolepsy](https://my.clevelandclinic.org/health/diseases/12147-narcolepsy). - [Shift work sleep disorder](https://my.clevelandclinic.org/health/diseases/12146-shift-work-sleep-disorder). #### Prescription medications and treatments Certain prescription medications can cause fatigue, including: Advertisement - [Benzodiazepines](https://my.clevelandclinic.org/health/treatments/24570-benzodiazepines-benzos). - Sedative-hypnotics. - Antipsychotics. - Anxiolytics. - [Opioids](https://my.clevelandclinic.org/health/articles/21127-opioids). - Anticonvulsants. - [Beta-blockers](https://my.clevelandclinic.org/health/treatments/22318-beta-blockers). #### Other medications and treatments Certain other medications and treatments can cause fatigue, including: - Over-the-counter (OTC) drugs, including [antihistamines](https://my.clevelandclinic.org/health/drugs/21223-antihistamines). - Bone marrow transplants. - [Chemotherapy](https://my.clevelandclinic.org/health/treatments/16859-chemotherapy). ### What medical conditions cause fatigue? Fatigue is a symptom of a wide range of diseases, disorders and deficiencies affecting various parts of your body. Hundreds of conditions and disorders can lead to fatigue. Some of the most common causes of fatigue include: #### Infections Many infections can cause fatigue, including: - [Mononucleosis](https://my.clevelandclinic.org/health/diseases/13974-mononucleosis). - [HIV](https://my.clevelandclinic.org/health/diseases/4251-aids--hiv). - [COVID-19](https://health.clevelandclinic.org/long-covid-symptoms-fatigue-and-breathlessness/). - [Influenza](https://my.clevelandclinic.org/health/diseases/4335-influenza-flu). - [Pneumonia](https://my.clevelandclinic.org/health/diseases/4471-pneumonia). - [Lyme disease](https://my.clevelandclinic.org/health/diseases/11586-lyme-disease). #### Heart and lung problems Fatigue is a common symptom of cardiovascular and lung conditions such as: - [Heart disease](https://my.clevelandclinic.org/health/diseases/24129-heart-disease). - [Postural orthostatic tachycardia syndrome (POTS)](https://health.clevelandclinic.org/why-am-i-so-tired). - [Chronic obstructive pulmonary disease (COPD)](https://my.clevelandclinic.org/health/diseases/8709-chronic-obstructive-pulmonary-disease-copd). - [Emphysema](https://my.clevelandclinic.org/health/diseases/9370-emphysema). - [Congestive heart failure](https://my.clevelandclinic.org/health/diseases/17069-heart-failure-understanding-heart-failure). #### Mental health conditions Fatigue due to certain mental health conditions may make it difficult or impossible to perform daily activities. These conditions may include: - Depression. - Anxiety. - [Post-traumatic stress disorder (PTSD)](https://my.clevelandclinic.org/health/diseases/9545-post-traumatic-stress-disorder-ptsd). #### Autoimmune disorders Fatigue is a symptom of many autoimmune diseases, including: - [Type 1 diabetes](https://my.clevelandclinic.org/health/diseases/21500-type-1-diabetes). - [Lupus](https://my.clevelandclinic.org/health/diseases/4875-lupus). - [Multiple sclerosis (MS).](https://my.clevelandclinic.org/health/diseases/17248-multiple-sclerosis) - [Myasthenia gravis](https://my.clevelandclinic.org/health/diseases/17252-myasthenia-gravis-mg). - [Rheumatoid arthritis](https://my.clevelandclinic.org/health/diseases/4924-rheumatoid-arthritis). - [Sjögren’s syndrome](https://my.clevelandclinic.org/health/diseases/4929-sjogrens-syndrome). #### Hormonal imbalances Problems with your [endocrine system](https://my.clevelandclinic.org/health/articles/21201-endocrine-system) (the glands in your body that make [hormones](https://health.clevelandclinic.org/the-truth-about-adrenal-fatigue/)) can lead to exhaustion. [Hypothyroidism](https://my.clevelandclinic.org/health/diseases/12120-hypothyroidism) is a common cause of fatigue. #### Other chronic conditions Certain chronic conditions can cause severe, long-lasting fatigue. These include: - [Cancer](https://my.clevelandclinic.org/health/diseases/12194-cancer). - [Chronic fatigue syndrome](https://my.clevelandclinic.org/health/diseases/17720-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs) (also called CFS or myalgic encephalomyelitis). - [Fibromyalgia](https://health.clevelandclinic.org/are-you-always-tired-and-achy/). - [Kidney disease](https://my.clevelandclinic.org/health/diseases/15096-kidney-disease-chronic-kidney-disease). - [Type 2 diabetes](https://my.clevelandclinic.org/health/diseases/21501-type-2-diabetes). #### Deficiencies [Anemia](https://my.clevelandclinic.org/health/diseases/3929-anemia) and other vitamin deficiencies (such as [vitamin D](https://my.clevelandclinic.org/health/diseases/15050-vitamin-d-vitamin-d-deficiency) or [vitamin B12](https://my.clevelandclinic.org/health/diseases/22831-vitamin-b12-deficiency)) are often responsible for fatigue. [Dehydration](https://my.clevelandclinic.org/health/treatments/9013-dehydration) can cause fatigue because the body needs plenty of fluids to function. #### Weight issues and eating disorders Certain weight issues and [eating disorders](https://my.clevelandclinic.org/health/diseases/4152-eating-disorders) can lead to fatigue and a range of other symptoms. These may include: - [Anorexia](https://my.clevelandclinic.org/health/diseases/9794-anorexia-nervosa). - [Bulimia](https://my.clevelandclinic.org/health/diseases/9795-bulimia-nervosa). - Overweight/[obesity](https://my.clevelandclinic.org/health/diseases/11209-weight-control-and-obesity). - Underweight. ## Care and Treatment ### How can my healthcare provider help me manage fatigue? To find out what’s causing your fatigue, your healthcare provider will ask questions about your lifestyle and medications. They’ll also conduct a physical examination. They might order some lab tests to check certain levels in your blood and urine. Your provider may also order a pregnancy test. To relieve fatigue, your provider will treat (or help you manage) the condition or disorder that’s causing it. Depending on your health, your treatment plan may include a combination of medication, exercise or therapy. If you’re taking a medication that makes you feel exhausted, talk to your provider about the risks and benefits of stopping the medication or trying a new one. Advertisement #### How can I ease or relieve fatigue at home? If a medical condition isn’t causing your fatigue, lifestyle changes may improve your symptoms. To reduce fatigue, you can: - **[Practice good sleep habits](https://health.clevelandclinic.org/how-to-know-if-your-fatigue-is-normal/):** Aim for seven to nine hours of sleep every night. Don’t drink caffeine, use electronics or exercise right before bed. Try to go to bed and get up at the same time every day. - **Avoid alcohol and substance use:** Don’t use illegal drugs, and drink alcohol in moderation, if at all. - **Eat a healthy diet:** A balanced diet and plenty of water will keep your body nourished and hydrated. - **Manage stress:** [Yoga](https://health.clevelandclinic.org/yoga-for-any-situation/), mindfulness, [meditation](https://my.clevelandclinic.org/health/articles/17906-meditation) and regular exercise can help you relieve stress and gain more energy. - **See your healthcare provider:** Make an appointment to rule out infections, disease, illness, vitamin deficiencies and other health conditions. You should also talk to your provider about the medications you’re taking to see if they’re causing your symptoms. - **Exercise often:** Regular [exercise](https://health.clevelandclinic.org/how-exercise-affects-your-sleep/) is crucial for a healthy lifestyle. Though it might seem counter-intuitive, vigorous exercise can help you feel more energetic once you get used to it. But exercising too much can cause fatigue, so talk to your provider about what’s best for you. - **Reach and maintain a healthy weight:** Talk to your healthcare provider about your ideal weight and try to stay within that range. Advertisement Care at Cleveland Clinic [Find a Primary Care Provider](https://my.clevelandclinic.org/services/primary-care) [Schedule an Appointment](https://my.clevelandclinic.org/services/primary-care#call-to-action-panel) ## When To Call the Doctor ### When should I call my healthcare provider about fatigue? It’s normal to feel tired now and then. Everyone experiences occasional, brief fatigue due to illness, sleep disturbances, travel or changes in diet or medication. But you should talk to your healthcare provider if you’re tired all the time. You should also call your provider if: - Your fatigue lasts longer than a few days. - You’re having a hard time going to work or performing daily activities. - There isn’t a clear reason (such as a recent illness) for your fatigue. - It comes on suddenly. - You’re over the age of 65. - You’ve also been losing weight. Fatigue can be a sign of a serious health condition. You should seek immediate medical attention if you have fatigue along with other symptoms, such as: - [Shortness of breath](https://my.clevelandclinic.org/health/symptoms/16942-dyspnea) or [pain in your chest](https://my.clevelandclinic.org/health/diseases/21489-angina), arm or upper back. - Heartbeat that’s unusually fast ([tachycardia](https://my.clevelandclinic.org/health/diseases/22108-tachycardia)) or slow ([bradycardia](https://my.clevelandclinic.org/health/diseases/17841-bradycardia)). - Heartbeat that’s pounding or fluttering ([heart palpitations](https://my.clevelandclinic.org/health/diseases/17084-heart-palpitations)) or irregular ([arrhythmia](https://my.clevelandclinic.org/health/diseases/16749-arrhythmia)). - Headache or vision problems (especially if you’ve hit your head recently). - [Nausea](https://my.clevelandclinic.org/health/symptoms/nausea), [vomiting](https://my.clevelandclinic.org/health/symptoms/vomiting) or [abdominal pain](https://my.clevelandclinic.org/health/symptoms/4167-abdominal-pain). - Muscle weakness. - [Thoughts of harming yourself](https://my.clevelandclinic.org/health/articles/11352-recognizing-suicidal-behavior) or others. ### A note from Cleveland Clinic Everyone has bouts of tiredness now and again. But fatigue makes it difficult for you to get up in the morning and make it through your day. Many factors can lead to fatigue, including health conditions, medications and lifestyle habits. If you’ve been feeling overly tired for more than a few days, reach out to your healthcare provider. They can help you figure out the underlying reason for your condition and help you treat or manage it. Advertisement [](https://my.clevelandclinic.org/)[](https://my.clevelandclinic.org/) [](https://health.clevelandclinic.org/)  ## Better health starts here Sign up for our Health Essentials emails for expert guidance on nutrition, fitness, sleep, skin care and more. [Example email](https://assets.clevelandclinic.org/transform/2ff943a2-abb1-4a1c-8ede-f8848703e789/HealthEssentials-SampleEmail-2026)[Sign up](https://my.clevelandclinic.org/health-essentials-sign-up) [Sign up](https://my.clevelandclinic.org/health-essentials-sign-up)[Example email](https://assets.clevelandclinic.org/transform/2ff943a2-abb1-4a1c-8ede-f8848703e789/HealthEssentials-SampleEmail-2026) ### Experts You Can Trust Medically Reviewed. Last updated on 04/13/2023. Learn more about the [Health Library](https://my.clevelandclinic.org/health/about) and our [editorial process](https://my.clevelandclinic.org/about/website/editorial-policy). ### References Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards. #### View Sources ### Experts You Can Trust Medically Reviewed. Last updated on 04/13/2023. ### References Cleveland Clinic’s health articles are based on evidence-backed information and review by medical professionals to ensure accuracy, reliability and up-to-date clinical standards. - American Cancer Society. Fatigue and Weakness *(https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/fatigue.html)*. Accessed 4/13/2023. - Merck Manual (Consumer Version). Fatigue *(https://www.merckmanuals.com/home/special-subjects/nonspecific-symptoms/fatigue)*. Accessed 4/13/2023. - U.K. National Health Service. Self-help tips to fight tiredness *(https://www.nhs.uk/live-well/sleep-and-tiredness/self-help-tips-to-fight-fatigue/)*. Accessed 4/13/2023. - U.S. National Cancer Institute. Fatigue (PDQ®) - Patient Version *(https://www.cancer.gov/about-cancer/treatment/side-effects/fatigue/fatigue-pdq)*. Accessed 4/13/2023. - U.S. National Institute on Aging. Fatigue in Older Adults *(https://www.nia.nih.gov/health/fatigue-older-adults)*. Accessed 4/13/2023. - U.S. National Library of Medicine. Fatigue *(https://medlineplus.gov/fatigue.html)*. Accessed 4/13/2023. ### Care at Cleveland Clinic Cleveland Clinic’s primary care providers offer lifelong medical care. From sinus infections and high blood pressure to preventive screening, we’re here for you.  [Find a Primary Care Provider](https://my.clevelandclinic.org/services/primary-care) [Schedule an Appointment](https://my.clevelandclinic.org/services/primary-care#call-to-action-panel) Advertisement Advertisement Ad Questions [216\.444.2538](tel:2164442538) [Appointments & Locations](https://my.clevelandclinic.org/departments/community-care/appointments-locations) [Request an Appointment](https://my.clevelandclinic.org/webappointment/what-to-expect) [Find a Primary Care Provider](https://my.clevelandclinic.org/services/primary-care) [Find a ProviderNeed a primary care doctor or a specialist? Our Find a Provider tool makes it easy to search Cleveland Clinic’s trusted network.](https://my.clevelandclinic.org/providers) [LocationsFind any of our 300+ locations.](https://my.clevelandclinic.org/locations) [AppointmentsGet the in-person or virtual care you need.](https://my.clevelandclinic.org/patients/information/access) ### Subscribe to Cleveland Clinic Health Essentials [Sign Up Today](https://my.clevelandclinic.org/health-essentials-newsletter?utm_medium=email&utm_source=jotform&utm_campaign=he&utm_content=signuppage) ### Actions [Appointments & Access](https://my.clevelandclinic.org/patients/information/access)[Accepted Insurance](https://my.clevelandclinic.org/patients/accepted-insurance)[Events Calendar](https://events.clevelandclinic.org/)[Financial Assistance](https://my.clevelandclinic.org/patients/billing-finance/financial-assistance)[Give to Cleveland Clinic](https://my.clevelandclinic.org/giving)[Pay Your Bill Online](https://my.clevelandclinic.org/patients/billing-finance/payment-options)[Price Transparency](https://my.clevelandclinic.org/patients/billing-finance/comprehensive-hospital-charges)[Refer a Patient](https://my.clevelandclinic.org/professionals/referring)[Phone Directory](https://my.clevelandclinic.org/about/contact/phone-directory)[Virtual Second Opinions](https://my.clevelandclinic.org/online-services/virtual-second-opinions)[Virtual Visits](https://my.clevelandclinic.org/online-services/virtual-visits) ### About Cleveland Clinic [100 Years of Cleveland Clinic](https://my.clevelandclinic.org/about/history)[About Us](https://my.clevelandclinic.org/about)[Locations](https://my.clevelandclinic.org/locations)[Quality & Patient Safety](https://my.clevelandclinic.org/departments/patient-experience/depts/quality-patient-safety)[Patient Experience](https://my.clevelandclinic.org/departments/patient-experience/depts/office-patient-experience)[Research & Innovations](https://my.clevelandclinic.org/research)[Community Commitment](https://my.clevelandclinic.org/about/community)[Careers](https://jobs.clevelandclinic.org/)[For Employees](https://my.clevelandclinic.org/about/for-employees)[Resources for Medical Professionals](https://my.clevelandclinic.org/professionals) ### Subscribe to Cleveland Clinic Health Essentials [Sign Up Today](https://my.clevelandclinic.org/health-essentials-newsletter?utm_medium=email&utm_source=jotform&utm_campaign=he&utm_content=signuppage) Follow Cleveland Clinic [](https://www.facebook.com/ClevelandClinic) [](https://twitter.com/clevelandclinic) [](https://www.youtube.com/user/clevelandclinic) [](https://www.instagram.com/clevelandclinic/) [](https://www.linkedin.com/company/cleveland-clinic) Blog, News & Apps [Consult QD](https://consultqd.clevelandclinic.org/) [Health Essentials](https://health.clevelandclinic.org/) [Newsroom](https://newsroom.clevelandclinic.org/) [MyClevelandClinic](https://my.clevelandclinic.org/mobile-apps/myclevelandclinic) [MyChart](https://my.clevelandclinic.org/online-services/mychart) Site Information & Policies [Send Us Feedback](https://my.clevelandclinic.org/webcontact/webmail) [About this Website](https://my.clevelandclinic.org/about/website) [Advertising Policy](https://health.clevelandclinic.org/advertising) [Social Media Policy](https://my.clevelandclinic.org/about/website/social-media) [Copyright, Reprint & Licensing](https://my.clevelandclinic.org/about/website/reprints-licensing) [Website Terms of Use](https://my.clevelandclinic.org/about/website/terms-of-use) [Privacy Policy](https://my.clevelandclinic.org/about/website/privacy-security) [Notice of Privacy Practices](https://my.clevelandclinic.org/about/website/privacy-practices) [Non-Discrimination and Availability](https://my.clevelandclinic.org/about/website/non-discrimination-notice) [Call: 800\.223.2273](tel:8002232273) \| 9500 Euclid Avenue, Cleveland, Ohio 44195 \| © 2026 Cleveland Clinic. All Rights Reserved.

### What causes fatigue? Many conditions, disorders, medications and lifestyle factors can cause fatigue. Fatigue can be temporary, or it can be a chronic condition (lasting six months or more). You may be able to quickly fix fatigue by changing your diet, medications, exercise or sleep habits. If an underlying medical condition is causing your fatigue, a healthcare provider can usually treat the condition or help you manage it. Fatigue causes include: #### Lifestyle habits Certain lifestyle factors can contribute to fatigue. These factors may include: #### Sleep disorders Certain sleep disorders can cause long-term exhaustion and extreme fatigue. These may include: #### Prescription medications and treatments Certain prescription medications can cause fatigue, including: - [Benzodiazepines](https://my.clevelandclinic.org/health/treatments/24570-benzodiazepines-benzos). - Sedative-hypnotics. - Antipsychotics. - Anxiolytics. - [Opioids](https://my.clevelandclinic.org/health/articles/21127-opioids). - Anticonvulsants. - [Beta-blockers](https://my.clevelandclinic.org/health/treatments/22318-beta-blockers). #### Other medications and treatments Certain other medications and treatments can cause fatigue, including: - Over-the-counter (OTC) drugs, including [antihistamines](https://my.clevelandclinic.org/health/drugs/21223-antihistamines). - Bone marrow transplants. - [Chemotherapy](https://my.clevelandclinic.org/health/treatments/16859-chemotherapy). ### What medical conditions cause fatigue? Fatigue is a symptom of a wide range of diseases, disorders and deficiencies affecting various parts of your body. Hundreds of conditions and disorders can lead to fatigue. Some of the most common causes of fatigue include: #### Infections Many infections can cause fatigue, including: #### Heart and lung problems Fatigue is a common symptom of cardiovascular and lung conditions such as: #### Mental health conditions Fatigue due to certain mental health conditions may make it difficult or impossible to perform daily activities. These conditions may include: #### Autoimmune disorders Fatigue is a symptom of many autoimmune diseases, including: #### Hormonal imbalances Problems with your [endocrine system](https://my.clevelandclinic.org/health/articles/21201-endocrine-system) (the glands in your body that make [hormones](https://health.clevelandclinic.org/the-truth-about-adrenal-fatigue/)) can lead to exhaustion. [Hypothyroidism](https://my.clevelandclinic.org/health/diseases/12120-hypothyroidism) is a common cause of fatigue. #### Other chronic conditions Certain chronic conditions can cause severe, long-lasting fatigue. These include: #### Deficiencies [Anemia](https://my.clevelandclinic.org/health/diseases/3929-anemia) and other vitamin deficiencies (such as [vitamin D](https://my.clevelandclinic.org/health/diseases/15050-vitamin-d-vitamin-d-deficiency) or [vitamin B12](https://my.clevelandclinic.org/health/diseases/22831-vitamin-b12-deficiency)) are often responsible for fatigue. [Dehydration](https://my.clevelandclinic.org/health/treatments/9013-dehydration) can cause fatigue because the body needs plenty of fluids to function. #### Weight issues and eating disorders Certain weight issues and [eating disorders](https://my.clevelandclinic.org/health/diseases/4152-eating-disorders) can lead to fatigue and a range of other symptoms. These may include: - [Anorexia](https://my.clevelandclinic.org/health/diseases/9794-anorexia-nervosa). - [Bulimia](https://my.clevelandclinic.org/health/diseases/9795-bulimia-nervosa). - Overweight/[obesity](https://my.clevelandclinic.org/health/diseases/11209-weight-control-and-obesity). - Underweight.