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Meta TitleCOVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C) | Nemours KidsHealth
Meta DescriptionCOVID-19 usually causes a mild infection in kids. But some develop more serious symptoms later on called multisystem inflammatory syndrome in children (MIS-C). Learn more here.
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Also called: Pediatric Multisystem Inflammatory Syndrome (PMIS); Pediatric Inflammatory Multisystem Syndrome (PIMS) What Is Multisystem Inflammatory Syndrome in Children (MIS-C)? COVID-19  usually causes a mild infection in kids. But some children develop more serious symptoms several weeks after being infected with the virus. This condition is called  multisystem inflammatory syndrome in children (MIS-C) . What Are the Signs of Multisystem Inflammatory Syndrome in Children (MIS-C)? MIS-C causes symptoms that are due to  inflammation  throughout the body. This may include: fever belly pain vomiting or diarrhea rash red, cracked lips red (bloodshot) eyes red or swollen hands or feet If your child has ongoing fever and any of these symptoms, call your doctor. Kids with this inflammatory syndrome may quickly get worse. Go to the ER right away if your child looks very sick, has trouble breathing, chest pain, bad belly pain, looks bluish in the lips or face, or is very sleepy or confused. Tell the doctor if your child had COVID-19 or has been exposed to someone who had it. What Problems Can Happen? MIS-C can cause different problems in different kids. The inflammation can affect the heart, blood cells, blood vessels, skin, digestive system, or eyes. Sometimes, this can damage the organs, especially the heart. How Is MIS-C Diagnosed? MIS-C symptoms can be similar to those caused by other illnesses, such as Kawasaki disease or toxic shock syndrome . If a doctor thinks a child might have MIS-C, they will do a COVID-19 test and other tests that look for signs of inflammation in the body. They will also do tests to look for damage to organs in the body. These can include: blood tests and urine (pee) tests chest X-ray tests to look at the heart, such as ECG (electrocardiogram) and echocardiogram (ultrasound of the heart) abdominal ultrasound The doctor might talk with a team of specialists who can help diagnose and treat MIS-C. They can include experts in infectious disease, cardiology (heart), rheumatology (bones, joints, and immune system), hematology  (blood), and critical care. Treatment & Care How Is MIS-C Treated? How doctors treat MIS-C depends on a child's symptoms and test results. They can give oxygen, medicines, and intravenous (IV) fluids to reduce inflammation, prevent excessive blood clotting, or protect the affected organs from more problems. Some children might need treatment in the ICU (intensive care unit). Most kids with MIS-C get better after being treated in the hospital. But some can have lasting problems and need care from specialists after they go home. For example, kids who develop heart problems due to MIS-C will need regular visits with a cardiologist . They may have to avoid exercise or sports for a while, until the cardiologist says it's OK. Kids who get some kinds of medicines (like steroids for easing inflammation) will see a specialist, such as a rheumatologist or endocrinologist , who can help them adjust their medicines as needed. What Else Should I Know? MIS-C is very rare. The best way to prevent it is to prevent COVID-19. Safe and effective  COVID-19 vaccines  help protect kids from COVID-19. This is especially important for those who are at high risk, including all kids between 6 months and 23 months. Talk to the doctor to see if your child is due for a vaccine. To help prevent the spread of germs, it’s always a good idea to: Wash hands well and often. Wash for at least 20 seconds with soap and water or use hand sanitizer with at least 60% alcohol. Avoid people who appear sick. Clean things that get touched a lot (like doorknobs, counters, phones, etc.). Try to breathe in cleaner air (by bringing in more fresh air from outside, purifying indoor air, or gathering outdoors).
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We've been providing trusted health information for 30 years. Learn More](https://kidshealth.org/en/parents/celebrating-30-years.html) - [Teens Home](https://kidshealth.org/en/teens/) - [Sitio para adolescentes](https://kidshealth.org/es/teens/) - [All Categories](https://kidshealth.org/en/teens/all-categories.html) - [All Wellness Centers](https://kidshealth.org/en/teens/centers/center.html) - [KidsHealth](https://kidshealth.org/) - [Parents](https://kidshealth.org/en/parents/) - COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C) # COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C) en español: [COVID-19 y el síndrome inflamatorio multisistémico en niños](https://kidshealth.org/es/parents/pmis.html) Medically reviewed by: [Larissa Hirsch, MDThis link opens in a new tab](https://www.nemours.org/about/kidshealth-medical-editors.html) [Learn About Cardiology (Heart Care) at Nemours Children's HealthThis link opens in a new tab](https://www.nemours.org/services/pediatric-cardiology.html) - [Listen](https://app-na.readspeaker.com/cgi-bin/rsent?customerid=5202&lang=en_us&readid=khcontent_article&url=kidshealth.org/en/parents/pmis.html "Listen to this page using ReadSpeaker") Play Stop Volume [mp3](https://app-na.readspeaker.com/cgi-bin/rsent?customerid=5202&lang=en_us&readid=khcontent_article&url=kidshealth.org/en/parents/pmis.html&audiofilename=KidsHealth_&save=1 "mp3") Settings Close Player - Larger text size Large text size Regular text size - [Print]() **Also called: Pediatric Multisystem Inflammatory Syndrome (PMIS); Pediatric Inflammatory Multisystem Syndrome (PIMS)** ## What Is Multisystem Inflammatory Syndrome in Children (MIS-C)? [COVID-19](https://kidshealth.org/en/parents/coronavirus.html) usually causes a mild infection in kids. But some children develop more serious symptoms several weeks after being infected with the virus. This condition is called **multisystem inflammatory** **syndrome in children (MIS-C)**. ## What Are the Signs of Multisystem Inflammatory Syndrome in Children (MIS-C)? MIS-C causes symptoms that are due to [inflammation](https://kidshealth.org/en/parents/inflammation.html) throughout the body. This may include: - [fever](https://kidshealth.org/en/parents/fever.html) - belly pain - vomiting or diarrhea - rash - red, cracked lips - red (bloodshot) eyes - red or swollen hands or feet If your child has ongoing fever and any of these symptoms, call your doctor. Kids with this inflammatory syndrome may quickly get worse. **[Go to the ER](https://kidshealth.org/en/parents/emergency-room.html) right away** if your child looks very sick, has trouble breathing, chest pain, bad belly pain, looks bluish in the lips or face, or is very sleepy or confused. Tell the doctor if your child had COVID-19 or has been exposed to someone who had it. ### What Problems Can Happen? MIS-C can cause different problems in different kids. The inflammation can affect the heart, blood cells, blood vessels, skin, digestive system, or eyes. Sometimes, this can damage the organs, especially the heart. ## How Is MIS-C Diagnosed? MIS-C symptoms can be similar to those caused by other illnesses, such as [Kawasaki disease](https://kidshealth.org/en/parents/kawasaki.html) or [toxic shock syndrome](https://kidshealth.org/en/parents/toxic-shock.html). If a doctor thinks a child might have MIS-C, they will do a [COVID-19 test](https://kidshealth.org/en/parents/coronavirus-tests.html) and other tests that look for signs of inflammation in the body. They will also do tests to look for damage to organs in the body. These can include: - blood tests and urine (pee) tests - [chest X-ray](https://kidshealth.org/en/parents/xray-exam-chest.html) - tests to look at the heart, such as [ECG (electrocardiogram)](https://kidshealth.org/en/parents/ekg.html) and [echocardiogram](https://kidshealth.org/en/parents/echo.html) (ultrasound of the heart) - [abdominal ultrasound](https://kidshealth.org/en/parents/ultrasound-abdomen.html) The doctor might talk with a team of specialists who can help diagnose and treat MIS-C. They can include experts in infectious disease, cardiology (heart), rheumatology (bones, joints, and immune system), [hematology](https://kidshealth.org/en/parents/hcp-hematology.html) (blood), and critical care. ## Treatment & Care ### How Is MIS-C Treated? How doctors treat MIS-C depends on a child's symptoms and test results. They can give oxygen, medicines, and [intravenous (IV)](https://kidshealth.org/en/parents/intravenous-line.html) fluids to reduce inflammation, prevent excessive blood clotting, or protect the affected organs from more problems. Some children might need treatment in the ICU (intensive care unit). Most kids with MIS-C get better after being treated in the hospital. But some can have lasting problems and need care from specialists after they go home. For example, kids who develop heart problems due to MIS-C will need regular visits with a [cardiologist](https://kidshealth.org/en/parents/hcp-cardiology.html). They may have to avoid exercise or sports for a while, until the cardiologist says it's OK. Kids who get some kinds of medicines (like steroids for easing inflammation) will see a specialist, such as a [rheumatologist](https://kidshealth.org/en/parents/hcp-rheumatology.html) or [endocrinologist](https://kidshealth.org/en/parents/hcp-endocrinology.html), who can help them adjust their medicines as needed. ## What Else Should I Know? MIS-C is very rare. The best way to prevent it is to prevent COVID-19. Safe and effective [COVID-19 vaccines](https://kidshealth.org/en/parents/covid-vaccines.html) help protect kids from COVID-19. This is especially important for those who are at high risk, including all kids between 6 months and 23 months. Talk to the doctor to see if your child is due for a vaccine. To help prevent the spread of germs, it’s always a good idea to: - [Wash hands](https://kidshealth.org/en/parents/hand-washing.html) well and often. Wash for at least 20 seconds with soap and water or use hand sanitizer with at least 60% alcohol. - Avoid people who appear sick. - Clean things that get touched a lot (like doorknobs, counters, phones, etc.). - Try to breathe in cleaner air (by bringing in more fresh air from outside, purifying indoor air, or gathering outdoors). **Medically reviewed by:** [Larissa Hirsch, MDThis link opens in a new tab](https://www.nemours.org/about/kidshealth-medical-editors.html) Date reviewed: October 2025 ## More on this topic for: - Parents ## More on this topic For Parents - [The COVID-19 Vaccine (Topic Center)](https://kidshealth.org/en/parents/center/vaccine.html) - [Understanding COVID-19](https://kidshealth.org/en/parents/coronavirus-landing-page.html) - [COVID-19: Questions & Answers About Vaccines](https://kidshealth.org/en/parents/covid-vaccines.html) - [Fever (High Temperature) In Kids](https://kidshealth.org/en/parents/fever.html) - [Taking Your Child's Temperature](https://kidshealth.org/en/parents/take-temperature.html) View more Share: - Share to Facebook - Share to Twitter - Share to Pinterest ## RELATED CATEGORIES - [Arthritis & Rheumatologic Conditions](https://kidshealth.org/en/parents/medical/arthritis.html) - [Bacterial & Viral Infections](https://kidshealth.org/en/parents/infections/bacterial-viral.html) - [Allergies & the Immune System](https://kidshealth.org/en/parents/medical/allergies.html) /content/kidshealth/misc/medicalcodes/parents/articles/pmis ##### Who We Are - [About Us](https://kidshealth.org/en/parents/about.html) ##### Working With Us - [Partners](https://kidshealth.org/en/parents/partners.html) - [Editorial Policy](https://kidshealth.org/en/parents/editorial-policy.html) - [Permissions Guidelines](https://kidshealth.org/en/parents/permissions-guidelines.html) - [Media Requests This link opens in a new tab](https://nemours.mediaroom.com/journalist-resources) - [Contact Us](https://kidshealth.org/en/parents/general-information/contact-us) ##### Legal & Privacy - [Privacy Policy & Terms of Use](https://kidshealth.org/en/parents/policy.html) - [Notice of Nondiscrimination](https://kidshealth.org/en/parents/nondiscrimination.html) ##### All Categories - [For Parents](https://kidshealth.org/en/parents/all-categories.html) - [For Kids](https://kidshealth.org/en/kids/all-categories.html) - [For Teens](https://kidshealth.org/en/teens/all-categories.html) ##### Wellness Centers - [For Parents](https://kidshealth.org/en/parents/centers/center.html) - [For Kids](https://kidshealth.org/en/kids/centers/center.html) - [For Teens](https://kidshealth.org/en/teens/centers/center.html) - [![Nemours KidsHealth on Facebook](https://kidshealth.org/content/dam/kh-reskin/iconFacebookWhite.svg)](https://www.facebook.com/nemourskidshealth/) - [![Nemours KidsHealth on X](https://kidshealth.org/content/dam/kh-reskin/iconTwitterWhite.svg)](https://x.com/nemours) - [![Nemours KidsHealth on YouTube](https://kidshealth.org/content/dam/kh-reskin/iconYoutubeWhite.svg)](https://www.youtube.com/@NemoursKidsHealth) [![Nemours](https://kidshealth.org/content/dam/kidshealth/logo-nemours_KidsHealth.svg)](https://www.nemours.org/?external_id=RE2350803010600) Note: All information on Nemours KidsHealth® is for educational purposes only. For specific medical advice, diagnoses, and treatment, consult your doctor. © 1995-2026. The Nemours Foundation. Nemours Children's Health®, Nemours KidsHealth®, KidsHealth®, and Well Beyond Medicine® are registered trademarks of The Nemours Foundation. All rights reserved. Images sourced by The Nemours Foundation and Getty Images.
Readable Markdown
**Also called: Pediatric Multisystem Inflammatory Syndrome (PMIS); Pediatric Inflammatory Multisystem Syndrome (PIMS)** ## What Is Multisystem Inflammatory Syndrome in Children (MIS-C)? [COVID-19](https://kidshealth.org/en/parents/coronavirus.html) usually causes a mild infection in kids. But some children develop more serious symptoms several weeks after being infected with the virus. This condition is called **multisystem inflammatory** **syndrome in children (MIS-C)**. ## What Are the Signs of Multisystem Inflammatory Syndrome in Children (MIS-C)? MIS-C causes symptoms that are due to [inflammation](https://kidshealth.org/en/parents/inflammation.html) throughout the body. This may include: - [fever](https://kidshealth.org/en/parents/fever.html) - belly pain - vomiting or diarrhea - rash - red, cracked lips - red (bloodshot) eyes - red or swollen hands or feet If your child has ongoing fever and any of these symptoms, call your doctor. Kids with this inflammatory syndrome may quickly get worse. **[Go to the ER](https://kidshealth.org/en/parents/emergency-room.html) right away** if your child looks very sick, has trouble breathing, chest pain, bad belly pain, looks bluish in the lips or face, or is very sleepy or confused. Tell the doctor if your child had COVID-19 or has been exposed to someone who had it. ### What Problems Can Happen? MIS-C can cause different problems in different kids. The inflammation can affect the heart, blood cells, blood vessels, skin, digestive system, or eyes. Sometimes, this can damage the organs, especially the heart. ## How Is MIS-C Diagnosed? MIS-C symptoms can be similar to those caused by other illnesses, such as [Kawasaki disease](https://kidshealth.org/en/parents/kawasaki.html) or [toxic shock syndrome](https://kidshealth.org/en/parents/toxic-shock.html). If a doctor thinks a child might have MIS-C, they will do a [COVID-19 test](https://kidshealth.org/en/parents/coronavirus-tests.html) and other tests that look for signs of inflammation in the body. They will also do tests to look for damage to organs in the body. These can include: - blood tests and urine (pee) tests - [chest X-ray](https://kidshealth.org/en/parents/xray-exam-chest.html) - tests to look at the heart, such as [ECG (electrocardiogram)](https://kidshealth.org/en/parents/ekg.html) and [echocardiogram](https://kidshealth.org/en/parents/echo.html) (ultrasound of the heart) - [abdominal ultrasound](https://kidshealth.org/en/parents/ultrasound-abdomen.html) The doctor might talk with a team of specialists who can help diagnose and treat MIS-C. They can include experts in infectious disease, cardiology (heart), rheumatology (bones, joints, and immune system), [hematology](https://kidshealth.org/en/parents/hcp-hematology.html) (blood), and critical care. ## Treatment & Care ### How Is MIS-C Treated? How doctors treat MIS-C depends on a child's symptoms and test results. They can give oxygen, medicines, and [intravenous (IV)](https://kidshealth.org/en/parents/intravenous-line.html) fluids to reduce inflammation, prevent excessive blood clotting, or protect the affected organs from more problems. Some children might need treatment in the ICU (intensive care unit). Most kids with MIS-C get better after being treated in the hospital. But some can have lasting problems and need care from specialists after they go home. For example, kids who develop heart problems due to MIS-C will need regular visits with a [cardiologist](https://kidshealth.org/en/parents/hcp-cardiology.html). They may have to avoid exercise or sports for a while, until the cardiologist says it's OK. Kids who get some kinds of medicines (like steroids for easing inflammation) will see a specialist, such as a [rheumatologist](https://kidshealth.org/en/parents/hcp-rheumatology.html) or [endocrinologist](https://kidshealth.org/en/parents/hcp-endocrinology.html), who can help them adjust their medicines as needed. ## What Else Should I Know? MIS-C is very rare. The best way to prevent it is to prevent COVID-19. Safe and effective [COVID-19 vaccines](https://kidshealth.org/en/parents/covid-vaccines.html) help protect kids from COVID-19. This is especially important for those who are at high risk, including all kids between 6 months and 23 months. Talk to the doctor to see if your child is due for a vaccine. To help prevent the spread of germs, it’s always a good idea to: - [Wash hands](https://kidshealth.org/en/parents/hand-washing.html) well and often. Wash for at least 20 seconds with soap and water or use hand sanitizer with at least 60% alcohol. - Avoid people who appear sick. - Clean things that get touched a lot (like doorknobs, counters, phones, etc.). - Try to breathe in cleaner air (by bringing in more fresh air from outside, purifying indoor air, or gathering outdoors).
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