🕷️ Crawler Inspector

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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 132 (from laksa100)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa132.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://healthify.nz/medicines-a-z/a/antidepressants\')), getAhrefsUnparsedNoserviceFromURL(\'https://healthify.nz/medicines-a-z/a/antidepressants\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants","crawl_time":1776087505,"first_indexed_time":1740958373,"http_code":200,"src_unparsed":"nz,healthify!\/medicines-a-z\/a\/antidepressants s443","src_root_hash":"10202082698416572132","history_drop_reason":null,"meta_title":"Antidepressants | Healthify","meta_descriptions":["Antidepressants are a group of medicines used to treat moderate to severe depression, when psychological therapy and lifestyle changes have not been enough for the depression to be managed."],"attrs_boilerpipe_text":"Key points about antidepressants\nAntidepressants are a group of medicines used to treat moderate to severe depression.\nAntidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes.\nRead about how to take antidepressants safely and possible side effects.\nAntidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about\ntreating depression\n. \nAntidepressants are not usually needed, and are often not very effective for mild depression.\nCBT\n, \ntalking\n \ntherapy\n and regular exercise work better for mild depression.\nAntidepressants are also used to treat other conditions such as\ngeneralised anxiety disorder (GAD)\n, \neating disorders\n,\nobsessive-compulsive disorder\nand\npost-traumatic stress disorder\n. They are also sometimes used to treat people with long-term (chronic) pain.\nImage credit: 123RF\nIf you need help or want to talk to somebody about your mental health, you can get support from any of the following:\nFree call or text 1737\n any time for support from a trained counsellor\nLifeline\n 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP)\nSuicide Crisis Helpline\n 0508 828 865 (0508 TAUTOKO)\nHealthline\n 0800 611 116\nSamaritans\n 0800 726 666.\nThere are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on:\nthe severity and type of your illness\nwhether you have other medical conditions\nother medicines you might be taking\nyour response to antidepressant medicines in the past\npossible side effects. \n \nAntidepressants available in Aotearoa New Zealand\nSelective serotonin reuptake inhibitors (SSRIs)\nExamples include\nfluoxetine\n, \nsertraline\n, \nparoxetine\n,\ncitalopram\n and\nescitalopram\n.\nSSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants.\nRead more about\nSSRIs.\nSerotonin and noradrenaline reuptake inhibitors (SNRIs)\nAn example is \nvenlafaxine.\nVenlafaxine is often used when SSRIs haven't been successful.\nTricyclic antidepressants (TCAs)\nExamples include \namitriptyline\n, clomipramine, dosulepin, \nimipramine\n, and\n \nnortriptyline. \nTCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as\nneuropathic pain\n and anxiety. \nMonoamine-oxidase inhibitors\n \nExamples are moclobemide and tranylcypromine.\nMAOIs are rarely used due to their side effects and the number of interactions with medicines and foods.\nOther antidepressants\nMirtazapine\nSome people find that herbal products like\nSt John's Wort\ncan be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking.\nWe don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion.\nWhile depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. S\nome people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you.  \nNeurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain.\nAntidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work.\nHow long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working.\nIf you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more.\nSome people get withdrawal symptoms when they try to reduce or stop taking an antidepressant. \nWithdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more.\nIf you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg,\n \namitriptyline, clomipramine, paroxetine and venlafaxine.\nTalk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about\n \nstopping antidepressants.\n(external link)\n \nTalk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns.\nLike all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy.\nAt the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine.\nRead more about\nmedicines and side effects\nand\nreporting a reaction you think might be a side effect\n.\nIf you suspect you, or someone you know, might be suffering from depression, read more from our\ndepression section\nor visit\nthelowdown.co.nz\n(external link)\nor\ndepression.org.nz\n(external link)\nfor helpful information, including a self-test. \nThe following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations.\nTreatments\n(external link)\nDepression.org.nz\nAntidepressants\n(external link)\nRoyal College of Psychiatrists, UK \nAntidepressants\n(external link)\n \nPatient Info, UK\nAntidepressants – selecting one that's right for you\n(external link)\n Mayo Clinic, US\nDepression – treatment options\n(external link)\nOption Grid\nResources\nStopping antidepressants: be cautious and go slow\n(external link)\n \nMedsafe and Ministry of Health, NZ, 2023\n5 questions to ask about your medications\n(external link)\n Health Quality and Safety Commission, NZ, 2019 \nEnglish\n(external link)\n,\nte reo Māori\n(external link)\nReferences\nThe role of medicines in the management of depression in primary care\n(external link)\nBPAC, NZ, 2021\nAntidepressant drugs\n(external link)\nNZ Formulary\nBrochures\n5 questions to ask about your medications\nHealth Quality and Safety Commission, NZ, 2019\nEnglish\nTe reo Māori\nFree helplines\nCredits:\nSandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.\nReviewed by:\nAngela Lambie, Pharmacist, Auckland\nLast reviewed:\n16 Oct 2022\nPage last updated:\n04 Dec 2022","attrs_markdown":"[Skip to main content](https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants#main)\n\n- [Healthify on Youtube](https:\/\/www.youtube.com\/@HealthifyNZ \"Watch us on Youtube\")\n- [Healthify on Instagram](https:\/\/www.instagram.com\/healthify.nz \"Follow us on Instagram\")\n- [Healthify on Facebook](https:\/\/facebook.com\/healthifyhepunawaiora \"Follow us on Facebook\")\n\n![logo black](https:\/\/healthify.nz\/assets\/Uploads\/logo-black.png)\n\n[![logo orange v2](https:\/\/healthify.nz\/assets\/Uploads\/logo-orange-v2.png)](https:\/\/healthify.nz\/)\n\n- [Health A–Z](https:\/\/healthify.nz\/health-a-z)\n  Show submenu for Health A–Z\n- - [A](https:\/\/healthify.nz\/health-a-z\/a)\n  - [B](https:\/\/healthify.nz\/health-a-z\/b)\n  - [C](https:\/\/healthify.nz\/health-a-z\/c)\n  - 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) **[Adopt a Page](https:\/\/adopt.healthify.nz\/)** on Healthify is coming back – relaunching soon\\!\n\n×\n\n1. [Home](https:\/\/healthify.nz\/)\n2. [Medicines A–Z](https:\/\/healthify.nz\/medicines-a-z)\n3. [A](https:\/\/healthify.nz\/medicines-a-z\/a)\n# Antidepressants\n\n### Key points about antidepressants\n- Antidepressants are a group of medicines used to treat moderate to severe depression.\n- Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes.\n- Read about how to take antidepressants safely and possible side effects.\n\n![HN 0789 female pharmacist working in dispensary of community pharmacy 1](https:\/\/healthify.nz\/assets\/Health-A-Z\/Medicines\/HN-0789-female-pharmacist-working-in-dispensary-of-community-pharmacy-1.jpg)\n\nQR Code\n\nPrint\n\nOpen all\n\nClose all\n\n#### What are antidepressants?\nAntidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about [treating depression](https:\/\/healthify.nz\/health-a-z\/d\/depression-overview).   \n  \nAntidepressants are not usually needed, and are often not very effective for mild depression. [CBT](https:\/\/healthify.nz\/health-a-z\/c\/cognitive-behavioural-therapy), talking therapy and regular exercise work better for mild depression.  \n  \nAntidepressants are also used to treat other conditions such as [generalised anxiety disorder (GAD)](https:\/\/healthify.nz\/health-a-z\/a\/anxiety \"Anxiety\"), [eating disorders](https:\/\/healthify.nz\/health-a-z\/e\/eating-disorders \"Eating disorders\"), [obsessive-compulsive disorder](https:\/\/healthify.nz\/health-a-z\/o\/obsessive-compulsive-disorder \"Obsessive compulsive disorder\") and [post-traumatic stress disorder](https:\/\/healthify.nz\/health-a-z\/p\/post-traumatic-stress-disorder-ptsd \"Post-traumatic stress disorder (PTSD)\"). They are also sometimes used to treat people with long-term (chronic) pain.\n\n![Young man talking to GP ](https:\/\/healthify.nz\/assets\/Card-Images\/woman-talking-to-gp-665x443-1-v2.jpg)   \n*Image credit: 123RF*\n\n#### I need help with my mental health\n**If you need help or want to talk to somebody about your mental health, you can get support from any of the following:**\n\n- **Free call or text 1737** any time for support from a trained counsellor\n- **Lifeline** 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP)\n- **Suicide Crisis Helpline** 0508 828 865 (0508 TAUTOKO)\n- **Healthline** 0800 611 116\n- **Samaritans** 0800 726 666.\n\n#### What to consider when choosing an antidepressant\nThere are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on:\n\n- the severity and type of your illness\n- whether you have other medical conditions\n- other medicines you might be taking\n- your response to antidepressant medicines in the past\n- possible side effects.\n\n| **Antidepressants available in Aotearoa New Zealand** |\n|---|\n| **Selective serotonin reuptake inhibitors (SSRIs)** Examples include [fluoxetine](https:\/\/healthify.nz\/medicines-a-z\/f\/fluoxetine \"Fluoxetine\"), [sertraline](https:\/\/healthify.nz\/medicines-a-z\/s\/sertraline \"Sertraline\"), [paroxetine](https:\/\/healthify.nz\/medicines-a-z\/p\/paroxetine \"Paroxetine\"), [citalopram](https:\/\/healthify.nz\/medicines-a-z\/c\/citalopram \"Citalopram\") and [escitalopram](https:\/\/healthify.nz\/medicines-a-z\/e\/escitalopram \"Escitalopram\"). SSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants. Read more about [SSRIs.](https:\/\/healthify.nz\/medicines-a-z\/s\/ssri-antidepressants \"SSRI antidepressants\") |\n| **Serotonin and noradrenaline reuptake inhibitors (SNRIs)** An example is [venlafaxine.](https:\/\/healthify.nz\/medicines-a-z\/v\/venlafaxine \"Venlafaxine\") Venlafaxine is often used when SSRIs haven't been successful. |\n| **Tricyclic antidepressants (TCAs)** Examples include [amitriptyline](https:\/\/healthify.nz\/medicines-a-z\/a\/amitriptyline \"Amitriptyline\"), clomipramine, dosulepin, [imipramine](https:\/\/healthify.nz\/medicines-a-z\/i\/imipramine \"Imipramine\"), and nortriptyline. TCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as [neuropathic pain](https:\/\/healthify.nz\/health-a-z\/n\/nerve-pain \"Nerve pain\") and anxiety. |\n| **Monoamine-oxidase inhibitors** Examples are moclobemide and tranylcypromine. MAOIs are rarely used due to their side effects and the number of interactions with medicines and foods. |\n| **Other antidepressants** [Mirtazapine](https:\/\/healthify.nz\/medicines-a-z\/m\/mirtazapine \"Mirtazapine\") |\n\n#### Can I use herbal supplements when taking antidepressants?\nSome people find that herbal products like [St John's Wort](https:\/\/healthify.nz\/medicines-a-z\/s\/st-john-s-wort \"St John’s wort\") can be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking.\n\n#### How do antidepressants work?\nWe don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion.  \n  \nWhile depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. Some people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you.   \n  \nNeurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain.\n\n#### How long will I need to take antidepressants for?\nAntidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work.   \n  \nHow long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working.\n\n#### Don't stop taking your antidepressant medicine suddenly\nIf you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more.\n\n- Some people get withdrawal symptoms when they try to reduce or stop taking an antidepressant.\n- Withdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more.\n- If you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg, amitriptyline, clomipramine, paroxetine and venlafaxine.\n\nTalk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about [stopping antidepressants.(external link)](https:\/\/www.medsafe.govt.nz\/Consumers\/educational-material\/Stopping-Antidepressant-medicines.pdf \"Open external link\")\n\nTalk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns.\n\n#### What to know about the side effects of antidepressants\nLike all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy.  \n  \nAt the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine.\n\nRead more about [medicines and side effects](https:\/\/healthify.nz\/medicines-a-z\/s\/side-effects-medicines) and [reporting a reaction you think might be a side effect](https:\/\/healthify.nz\/medicines-a-z\/s\/side-effects-reporting).\n\n#### Related topics on Healthify\n[Depression \\| Mate pāpouri](https:\/\/healthify.nz\/health-a-z\/d\/depression-overview\/ \"Depression | Mate pāpouri\")  \n[Perinatal depression](https:\/\/healthify.nz\/health-a-z\/d\/depression-perinatal\/ \"Perinatal depression\")  \n[Antidepressants in pregnancy](https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants-in-pregnancy)  \n[How to support a child or teenager with depression](https:\/\/healthify.nz\/health-a-z\/d\/depression-children-and-teenagers\/ \"How to support a child or teenager with depression\")  \n[Depression in later life](https:\/\/healthify.nz\/health-a-z\/d\/depression-later-life\/ \"Depression in later life\")  \n[Anxiety \\| Mate māharahara](https:\/\/healthify.nz\/health-a-z\/a\/anxiety\/ \"Anxiety | Mate māharahara\")  \n[Cognitive behavioural therapy (CBT)](https:\/\/healthify.nz\/health-a-z\/c\/cognitive-behavioural-therapy)  \n[Nerve pain](https:\/\/healthify.nz\/health-a-z\/n\/nerve-pain\/ \"Nerve pain\")  \n[Obsessive compulsive disorder (OCD)](https:\/\/healthify.nz\/health-a-z\/o\/obsessive-compulsive-disorder\/ \"Obsessive compulsive disorder (OCD)\")\n\n#### More information\nIf you suspect you, or someone you know, might be suffering from depression, read more from our [depression section](https:\/\/healthify.nz\/health-a-z\/d\/depression-overview \"Depression\") or visit [thelowdown.co.nz(external link)](http:\/\/thelowdown.co.nz\/#\/home\/ \"Open external link\") or [depression.org.nz(external link)](http:\/\/www.depression.org.nz\/ \"Open external link\") for helpful information, including a self-test.\n\nThe following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations.\n\n[Treatments(external link)](https:\/\/depression.org.nz\/get-better\/treatments\/ \"Open external link\") Depression.org.nz  \n[Antidepressants(external link)](https:\/\/www.rcpsych.ac.uk\/expertadvice\/treatmentswellbeing\/antidepressants.aspx \"Open external link\") Royal College of Psychiatrists, UK   \n[Antidepressants(external link)](https:\/\/patient.info\/mental-health\/depression-leaflet\/antidepressants \"Open external link\") Patient Info, UK  \n[Antidepressants – selecting one that's right for you(external link)](http:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046273 \"Open external link\") Mayo Clinic, US  \n[Depression – treatment options(external link)](https:\/\/www.optiongrid.org\/option-grids\/grid-landing\/92\/ \"Open external link\") Option Grid\n\n#### Resources\n[Stopping antidepressants: be cautious and go slow(external link)](https:\/\/www.medsafe.govt.nz\/Consumers\/educational-material\/Stopping-Antidepressant-medicines.pdf \"Open external link\") Medsafe and Ministry of Health, NZ, 2023  \n[5 questions to ask about your medications(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"Open external link\") Health Quality and Safety Commission, NZ, 2019 [English(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"Open external link\"), [te reo Māori(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf \"Open external link\")\n\n#### References\n1. [The role of medicines in the management of depression in primary care(external link)](https:\/\/bpac.org.nz\/2021\/depression.aspx \"Open external link\") BPAC, NZ, 2021\n2. [Antidepressant drugs(external link)](http:\/\/nzf.org.nz\/nzf_2225 \"Open external link\") NZ Formulary\n\n## Brochures\n![](https:\/\/healthify.nz\/assets\/Brochures\/stopping-antidepressants-be-cautious-and-go-slow-medsafe__ResizedImageWzEwOCwxNTdd.png) [Stopping antidepressants: be cautious and go slow](https:\/\/www.medsafe.govt.nz\/Consumers\/educational-material\/Stopping-Antidepressant-medicines.pdf) Medsafe NZ and Ministry of Health, NZ, 2023\n\n![](https:\/\/healthify.nz\/assets\/Brochures\/Healthify-Resources\/medicine-side-effects__ResizedImageWzIwMCwxNDBd.jpg)\n\n[Medicines and side effects](https:\/\/healthify.nz\/assets\/Brochures\/Healthify-Resources\/Medicines-side-effects-FINAL.pdf)  \nHealthify He Puna Waiora, NZ, 2024\n\n![Image not found](https:\/\/healthify.nz\/assets\/5-questions-to-ask-about-your-medications.jpg)   \n5 questions to ask about your medications  \nHealth Quality and Safety Commission, NZ, 2019\n\n[English](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"English\")  \n[Te reo Māori](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf \"Te reo Māori\")\n\n## Free helplines\n[![Healthline logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Healthline-Supporters-Block__ResizedImageWzMwMCwxNTBd.png)](https:\/\/www.healthy.org.nz\/ \"Contact Healthline \")\n\n[![Text 1737 Helpline logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Need-to-talk-1737-logo-800x400__ResizedImageWzMwMCwxNTBd.png)](https:\/\/1737.org.nz\/ \"Contact 1737\")\n\n[![Healthpoint logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Health-Point-logo__ResizedImageWzMwMCwxNTBd.png)](https:\/\/www.healthpoint.co.nz\/ \"Healthpoint website\")\n\n[Share on facebook](https:\/\/facebook.com\/sharer\/sharer.php?u=https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants)\n\n[Email](https:\/\/healthify.nz\/cdn-cgi\/l\/email-protection#407f3335222a2523347d012e342924253032253333212e3433603c600825212c342829263966212d307b222f24397d65700465700165700465700128343430337a6f6f2825212c34282926396e2e3a6f2d25242923292e25336d216d3a6f216f212e342924253032253333212e34336e)\n\n[Share on Linked In](https:\/\/www.linkedin.com\/sharing\/share-offsite\/?url=https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants)\n\nCredits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.\n\nReviewed by: Angela Lambie, Pharmacist, Auckland\n\nLast reviewed: 16 Oct 2022\n\nPage last updated: 04 Dec 2022\n\nScan the QR code to view the full page:   \n https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants\n\n![image](https:\/\/healthify.nz\/assets\/Uploads\/image.png)\n\n[![Healthify He Puna Waiora logo in orange](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Healthify-Logo-Orange__ResizedImageWzI1MSwxMjRd.png)](https:\/\/healthify.nz\/)\n\n[![](https:\/\/healthify.nz\/assets\/Affiliate-Images\/HNCT-logo-for-footer.jpg)](https:\/\/www.hnct.nz\/)\n\n[![](https:\/\/healthify.nz\/assets\/Affiliate-Images\/zerodata-logo-rgb-supplied__ResizedImageWzE1OCw3NV0.jpg)](https:\/\/portal.zero.govt.nz\/28f2e4000bd5a26366ede8abb548f277 \"Link to Healthify using ZeroData\")\n\n**[Home](https:\/\/healthify.nz\/)**\n\n[Health A–Z](https:\/\/healthify.nz\/health-a-z)\n\n[Medicines A–Z](https:\/\/healthify.nz\/medicines-a-z)\n\n[Hauora Wellbeing](https:\/\/healthify.nz\/hauora-wellbeing)\n\n[Care & Support](https:\/\/healthify.nz\/care-and-support)\n\n[App Library](https:\/\/healthify.nz\/app-library)\n\n[Tools](https:\/\/healthify.nz\/tools)\n\n[News](https:\/\/healthify.nz\/news)\n\n[Newsletters](https:\/\/healthify.nz\/newsletters-sign-up \"Sign up to our newsletters\")\n\n[Leave a review](https:\/\/socialjuice.io\/p\/healthify \"Link to provide feedback about our site\")\n\n**[About Healthify](https:\/\/healthify.nz\/about-healthify)**\n\n[Testimonials](https:\/\/healthify.nz\/testimonials)\n\n[About Health Navigator Charitable Trust](https:\/\/www.hnct.nz\/)\n\n[Volunteer \/ Work with us](https:\/\/healthify.nz\/about-healthify\/volunteer)\n\n[Accessibility](https:\/\/healthify.nz\/about-healthify\/our-policies#accessibility)\n\n[Privacy & Cookies Policy](https:\/\/healthify.nz\/about-healthify\/our-policies#privacy-cookies)\n\n[Disclaimer](https:\/\/healthify.nz\/about-healthify\/our-policies#disclaimer)\n\n[Contact](https:\/\/healthify.nz\/contact)\n\n[Donate](https:\/\/donate.healthify.nz\/?utm_source=Healthify&utm_medium=footer_link)\n\n**[For Healthcare Providers](https:\/\/healthify.nz\/healthcare-providers)**\n\n[Resources](https:\/\/healthify.nz\/about-healthify\/resources)\n\n[Journey to Wellbeing \\| Huarahi Ora](https:\/\/www.journeytowellbeing.nz\/)\n\n[Translations](https:\/\/healthify.nz\/translations)\n\n[Medicine factsheets & videos](https:\/\/healthify.nz\/medicines-a-z\/m\/medicine-brand-changes-factsheets-and-videos)\n\n[Te Kete Haerenga](https:\/\/healthify.nz\/tools\/t\/te-kete-haerenga-wellness-toolkit)\n\n[![RNZCGP logo showing endorsement of Healthify](https:\/\/healthify.nz\/assets\/Affiliate-Images\/RNZCGP-Endorsed-GUIDANCE-logo-Exp-31-Mar-2027__ResizedImageWzE3MCwxNzBd.png)](https:\/\/healthify.nz\/about-healthify\/why-you-can-trust-us \"rnzcgp-endorsement\")\n\nScroll to Top\n\n[![shielded](https:\/\/healthify.nz\/_resources\/themes\/catalyst-starter\/dist\/img\/shielded_site_logo.png?m=1736474156)](https:\/\/healthify.nz\/medicines-a-z\/a\/antidepressants)\n\n© 2026 Health Navigator Charitable Trust CC36318. All rights reserved.","attrs_readable_markdown":"### Key points about antidepressants\n- Antidepressants are a group of medicines used to treat moderate to severe depression.\n- Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes.\n- Read about how to take antidepressants safely and possible side effects.\n\n![HN 0789 female pharmacist working in dispensary of community pharmacy 1](https:\/\/healthify.nz\/assets\/Health-A-Z\/Medicines\/HN-0789-female-pharmacist-working-in-dispensary-of-community-pharmacy-1.jpg)\n\nAntidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about [treating depression](https:\/\/healthify.nz\/health-a-z\/d\/depression-overview).\n\nAntidepressants are not usually needed, and are often not very effective for mild depression. [CBT](https:\/\/healthify.nz\/health-a-z\/c\/cognitive-behavioural-therapy), talking therapy and regular exercise work better for mild depression.\n\nAntidepressants are also used to treat other conditions such as [generalised anxiety disorder (GAD)](https:\/\/healthify.nz\/health-a-z\/a\/anxiety \"Anxiety\"), [eating disorders](https:\/\/healthify.nz\/health-a-z\/e\/eating-disorders \"Eating disorders\"), [obsessive-compulsive disorder](https:\/\/healthify.nz\/health-a-z\/o\/obsessive-compulsive-disorder \"Obsessive compulsive disorder\") and [post-traumatic stress disorder](https:\/\/healthify.nz\/health-a-z\/p\/post-traumatic-stress-disorder-ptsd \"Post-traumatic stress disorder (PTSD)\"). They are also sometimes used to treat people with long-term (chronic) pain.\n\n![Young man talking to GP ](https:\/\/healthify.nz\/assets\/Card-Images\/woman-talking-to-gp-665x443-1-v2.jpg)   \n*Image credit: 123RF*\n\n**If you need help or want to talk to somebody about your mental health, you can get support from any of the following:**\n\n- **Free call or text 1737** any time for support from a trained counsellor\n- **Lifeline** 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP)\n- **Suicide Crisis Helpline** 0508 828 865 (0508 TAUTOKO)\n- **Healthline** 0800 611 116\n- **Samaritans** 0800 726 666.\n\nThere are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on:\n\n- the severity and type of your illness\n- whether you have other medical conditions\n- other medicines you might be taking\n- your response to antidepressant medicines in the past\n- possible side effects.\n\n| **Antidepressants available in Aotearoa New Zealand** |\n|---|\n| **Selective serotonin reuptake inhibitors (SSRIs)** Examples include [fluoxetine](https:\/\/healthify.nz\/medicines-a-z\/f\/fluoxetine \"Fluoxetine\"), [sertraline](https:\/\/healthify.nz\/medicines-a-z\/s\/sertraline \"Sertraline\"), [paroxetine](https:\/\/healthify.nz\/medicines-a-z\/p\/paroxetine \"Paroxetine\"), [citalopram](https:\/\/healthify.nz\/medicines-a-z\/c\/citalopram \"Citalopram\") and [escitalopram](https:\/\/healthify.nz\/medicines-a-z\/e\/escitalopram \"Escitalopram\"). SSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants. Read more about [SSRIs.](https:\/\/healthify.nz\/medicines-a-z\/s\/ssri-antidepressants \"SSRI antidepressants\") |\n| **Serotonin and noradrenaline reuptake inhibitors (SNRIs)** An example is [venlafaxine.](https:\/\/healthify.nz\/medicines-a-z\/v\/venlafaxine \"Venlafaxine\") Venlafaxine is often used when SSRIs haven't been successful. |\n| **Tricyclic antidepressants (TCAs)** Examples include [amitriptyline](https:\/\/healthify.nz\/medicines-a-z\/a\/amitriptyline \"Amitriptyline\"), clomipramine, dosulepin, [imipramine](https:\/\/healthify.nz\/medicines-a-z\/i\/imipramine \"Imipramine\"), and nortriptyline. TCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as [neuropathic pain](https:\/\/healthify.nz\/health-a-z\/n\/nerve-pain \"Nerve pain\") and anxiety. |\n| **Monoamine-oxidase inhibitors** Examples are moclobemide and tranylcypromine. MAOIs are rarely used due to their side effects and the number of interactions with medicines and foods. |\n| **Other antidepressants** [Mirtazapine](https:\/\/healthify.nz\/medicines-a-z\/m\/mirtazapine \"Mirtazapine\") |\n\nSome people find that herbal products like [St John's Wort](https:\/\/healthify.nz\/medicines-a-z\/s\/st-john-s-wort \"St John’s wort\") can be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking.\n\nWe don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion.\n\nWhile depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. Some people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you.\n\nNeurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain.\n\nAntidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work.\n\nHow long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working.\n\nIf you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more.\n\n- Some people get withdrawal symptoms when they try to reduce or stop taking an antidepressant.\n- Withdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more.\n- If you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg, amitriptyline, clomipramine, paroxetine and venlafaxine.\n\nTalk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about [stopping antidepressants.(external link)](https:\/\/www.medsafe.govt.nz\/Consumers\/educational-material\/Stopping-Antidepressant-medicines.pdf \"Open external link\")\n\nTalk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns.\n\nLike all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy.\n\nAt the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine.\n\nRead more about [medicines and side effects](https:\/\/healthify.nz\/medicines-a-z\/s\/side-effects-medicines) and [reporting a reaction you think might be a side effect](https:\/\/healthify.nz\/medicines-a-z\/s\/side-effects-reporting).\n\nIf you suspect you, or someone you know, might be suffering from depression, read more from our [depression section](https:\/\/healthify.nz\/health-a-z\/d\/depression-overview \"Depression\") or visit [thelowdown.co.nz(external link)](http:\/\/thelowdown.co.nz\/#\/home\/ \"Open external link\") or [depression.org.nz(external link)](http:\/\/www.depression.org.nz\/ \"Open external link\") for helpful information, including a self-test.\n\nThe following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations.\n\n[Treatments(external link)](https:\/\/depression.org.nz\/get-better\/treatments\/ \"Open external link\") Depression.org.nz  \n[Antidepressants(external link)](https:\/\/www.rcpsych.ac.uk\/expertadvice\/treatmentswellbeing\/antidepressants.aspx \"Open external link\") Royal College of Psychiatrists, UK   \n[Antidepressants(external link)](https:\/\/patient.info\/mental-health\/depression-leaflet\/antidepressants \"Open external link\") Patient Info, UK  \n[Antidepressants – selecting one that's right for you(external link)](http:\/\/www.mayoclinic.org\/diseases-conditions\/depression\/in-depth\/antidepressants\/art-20046273 \"Open external link\") Mayo Clinic, US  \n[Depression – treatment options(external link)](https:\/\/www.optiongrid.org\/option-grids\/grid-landing\/92\/ \"Open external link\") Option Grid\n\n#### Resources\n[Stopping antidepressants: be cautious and go slow(external link)](https:\/\/www.medsafe.govt.nz\/Consumers\/educational-material\/Stopping-Antidepressant-medicines.pdf \"Open external link\") Medsafe and Ministry of Health, NZ, 2023  \n[5 questions to ask about your medications(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"Open external link\") Health Quality and Safety Commission, NZ, 2019 [English(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"Open external link\"), [te reo Māori(external link)](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf \"Open external link\")\n\n#### References\n1. [The role of medicines in the management of depression in primary care(external link)](https:\/\/bpac.org.nz\/2021\/depression.aspx \"Open external link\") BPAC, NZ, 2021\n2. [Antidepressant drugs(external link)](http:\/\/nzf.org.nz\/nzf_2225 \"Open external link\") NZ Formulary\n\nBrochures\n\n![Image not found](https:\/\/healthify.nz\/assets\/5-questions-to-ask-about-your-medications.jpg)   \n5 questions to ask about your medications  \nHealth Quality and Safety Commission, NZ, 2019\n\n[English](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf \"English\")  \n[Te reo Māori](https:\/\/www.hqsc.govt.nz\/assets\/Our-work\/System-safety\/Reducing-harm\/Medicines\/Publications-resources\/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf \"Te reo Māori\")\n\nFree helplines\n\n[![Healthline logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Healthline-Supporters-Block__ResizedImageWzMwMCwxNTBd.png)](https:\/\/www.healthy.org.nz\/ \"Contact Healthline \")\n\n[![Text 1737 Helpline logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Need-to-talk-1737-logo-800x400__ResizedImageWzMwMCwxNTBd.png)](https:\/\/1737.org.nz\/ \"Contact 1737\")\n\n[![Healthpoint logo](https:\/\/healthify.nz\/assets\/Affiliate-Images\/Health-Point-logo__ResizedImageWzMwMCwxNTBd.png)](https:\/\/www.healthpoint.co.nz\/ \"Healthpoint website\")\n\nCredits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust.\n\nReviewed by: Angela Lambie, Pharmacist, Auckland\n\nLast reviewed: 16 Oct 2022\n\nPage last updated: 04 Dec 2022","meta_canonical":null}

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Last Crawled	2026-04-13 13:38:25 (56 minutes ago)
First Indexed	2025-03-02 23:32:53 (1 year ago)
HTTP Status Code	200
Meta Title	Antidepressants \| Healthify
Meta Description	Antidepressants are a group of medicines used to treat moderate to severe depression, when psychological therapy and lifestyle changes have not been enough for the depression to be managed.
Meta Canonical	null
Boilerpipe Text	Key points about antidepressants Antidepressants are a group of medicines used to treat moderate to severe depression. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read about how to take antidepressants safely and possible side effects. Antidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about treating depression . Antidepressants are not usually needed, and are often not very effective for mild depression. CBT , talking therapy and regular exercise work better for mild depression. Antidepressants are also used to treat other conditions such as generalised anxiety disorder (GAD) , eating disorders , obsessive-compulsive disorder and post-traumatic stress disorder . They are also sometimes used to treat people with long-term (chronic) pain. Image credit: 123RF If you need help or want to talk to somebody about your mental health, you can get support from any of the following: Free call or text 1737 any time for support from a trained counsellor Lifeline 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP) Suicide Crisis Helpline 0508 828 865 (0508 TAUTOKO) Healthline 0800 611 116 Samaritans 0800 726 666. There are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on: the severity and type of your illness whether you have other medical conditions other medicines you might be taking your response to antidepressant medicines in the past possible side effects. Antidepressants available in Aotearoa New Zealand Selective serotonin reuptake inhibitors (SSRIs) Examples include fluoxetine , sertraline , paroxetine , citalopram and escitalopram . SSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants. Read more about SSRIs. Serotonin and noradrenaline reuptake inhibitors (SNRIs) An example is venlafaxine. Venlafaxine is often used when SSRIs haven't been successful. Tricyclic antidepressants (TCAs) Examples include amitriptyline , clomipramine, dosulepin, imipramine , and nortriptyline. TCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as neuropathic pain and anxiety. Monoamine-oxidase inhibitors Examples are moclobemide and tranylcypromine. MAOIs are rarely used due to their side effects and the number of interactions with medicines and foods. Other antidepressants Mirtazapine Some people find that herbal products like St John's Wort can be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking. We don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion. While depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. S ome people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you. Neurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain. Antidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work. How long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working. If you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more. Some people get withdrawal symptoms when they try to reduce or stop taking an antidepressant. Withdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more. If you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg, amitriptyline, clomipramine, paroxetine and venlafaxine. Talk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about stopping antidepressants. (external link) Talk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns. Like all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy. At the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine. Read more about medicines and side effects and reporting a reaction you think might be a side effect . If you suspect you, or someone you know, might be suffering from depression, read more from our depression section or visit thelowdown.co.nz (external link) or depression.org.nz (external link) for helpful information, including a self-test. The following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations. Treatments (external link) Depression.org.nz Antidepressants (external link) Royal College of Psychiatrists, UK Antidepressants (external link) Patient Info, UK Antidepressants – selecting one that's right for you (external link) Mayo Clinic, US Depression – treatment options (external link) Option Grid Resources Stopping antidepressants: be cautious and go slow (external link) Medsafe and Ministry of Health, NZ, 2023 5 questions to ask about your medications (external link) Health Quality and Safety Commission, NZ, 2019 English (external link) , te reo Māori (external link) References The role of medicines in the management of depression in primary care (external link) BPAC, NZ, 2021 Antidepressant drugs (external link) NZ Formulary Brochures 5 questions to ask about your medications Health Quality and Safety Commission, NZ, 2019 English Te reo Māori Free helplines Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust. Reviewed by: Angela Lambie, Pharmacist, Auckland Last reviewed: 16 Oct 2022 Page last updated: 04 Dec 2022
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) [Adopt a Page](https://adopt.healthify.nz/) on Healthify is coming back – relaunching soon\! × 1. [Home](https://healthify.nz/) 2. [Medicines A–Z](https://healthify.nz/medicines-a-z) 3. [A](https://healthify.nz/medicines-a-z/a) # Antidepressants ### Key points about antidepressants - Antidepressants are a group of medicines used to treat moderate to severe depression. - Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. - Read about how to take antidepressants safely and possible side effects. ![HN 0789 female pharmacist working in dispensary of community pharmacy 1](https://healthify.nz/assets/Health-A-Z/Medicines/HN-0789-female-pharmacist-working-in-dispensary-of-community-pharmacy-1.jpg) QR Code Print Open all Close all #### What are antidepressants? Antidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about [treating depression](https://healthify.nz/health-a-z/d/depression-overview). Antidepressants are not usually needed, and are often not very effective for mild depression. [CBT](https://healthify.nz/health-a-z/c/cognitive-behavioural-therapy), talking therapy and regular exercise work better for mild depression. Antidepressants are also used to treat other conditions such as [generalised anxiety disorder (GAD)](https://healthify.nz/health-a-z/a/anxiety "Anxiety"), [eating disorders](https://healthify.nz/health-a-z/e/eating-disorders "Eating disorders"), [obsessive-compulsive disorder](https://healthify.nz/health-a-z/o/obsessive-compulsive-disorder "Obsessive compulsive disorder") and [post-traumatic stress disorder](https://healthify.nz/health-a-z/p/post-traumatic-stress-disorder-ptsd "Post-traumatic stress disorder (PTSD)"). They are also sometimes used to treat people with long-term (chronic) pain. ![Young man talking to GP ](https://healthify.nz/assets/Card-Images/woman-talking-to-gp-665x443-1-v2.jpg) Image credit: 123RF #### I need help with my mental health If you need help or want to talk to somebody about your mental health, you can get support from any of the following: - Free call or text 1737 any time for support from a trained counsellor - Lifeline 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP) - Suicide Crisis Helpline 0508 828 865 (0508 TAUTOKO) - Healthline 0800 611 116 - Samaritans 0800 726 666. #### What to consider when choosing an antidepressant There are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on: - the severity and type of your illness - whether you have other medical conditions - other medicines you might be taking - your response to antidepressant medicines in the past - possible side effects. \| Antidepressants available in Aotearoa New Zealand \| \|---\| \| Selective serotonin reuptake inhibitors (SSRIs) Examples include [fluoxetine](https://healthify.nz/medicines-a-z/f/fluoxetine "Fluoxetine"), [sertraline](https://healthify.nz/medicines-a-z/s/sertraline "Sertraline"), [paroxetine](https://healthify.nz/medicines-a-z/p/paroxetine "Paroxetine"), [citalopram](https://healthify.nz/medicines-a-z/c/citalopram "Citalopram") and [escitalopram](https://healthify.nz/medicines-a-z/e/escitalopram "Escitalopram"). SSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants. Read more about [SSRIs.](https://healthify.nz/medicines-a-z/s/ssri-antidepressants "SSRI antidepressants") \| \| Serotonin and noradrenaline reuptake inhibitors (SNRIs) An example is [venlafaxine.](https://healthify.nz/medicines-a-z/v/venlafaxine "Venlafaxine") Venlafaxine is often used when SSRIs haven't been successful. \| \| Tricyclic antidepressants (TCAs) Examples include [amitriptyline](https://healthify.nz/medicines-a-z/a/amitriptyline "Amitriptyline"), clomipramine, dosulepin, [imipramine](https://healthify.nz/medicines-a-z/i/imipramine "Imipramine"), and nortriptyline. TCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as [neuropathic pain](https://healthify.nz/health-a-z/n/nerve-pain "Nerve pain") and anxiety. \| \| Monoamine-oxidase inhibitors Examples are moclobemide and tranylcypromine. MAOIs are rarely used due to their side effects and the number of interactions with medicines and foods. \| \| Other antidepressants [Mirtazapine](https://healthify.nz/medicines-a-z/m/mirtazapine "Mirtazapine") \| #### Can I use herbal supplements when taking antidepressants? Some people find that herbal products like [St John's Wort](https://healthify.nz/medicines-a-z/s/st-john-s-wort "St John’s wort") can be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking. #### How do antidepressants work? We don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion. While depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. Some people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you. Neurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain. #### How long will I need to take antidepressants for? Antidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work. How long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working. #### Don't stop taking your antidepressant medicine suddenly If you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more. - Some people get withdrawal symptoms when they try to reduce or stop taking an antidepressant. - Withdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more. - If you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg, amitriptyline, clomipramine, paroxetine and venlafaxine. Talk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about [stopping antidepressants.(external link)](https://www.medsafe.govt.nz/Consumers/educational-material/Stopping-Antidepressant-medicines.pdf "Open external link") Talk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns. #### What to know about the side effects of antidepressants Like all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy. At the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine. Read more about [medicines and side effects](https://healthify.nz/medicines-a-z/s/side-effects-medicines) and [reporting a reaction you think might be a side effect](https://healthify.nz/medicines-a-z/s/side-effects-reporting). #### Related topics on Healthify [Depression \\| Mate pāpouri](https://healthify.nz/health-a-z/d/depression-overview/ "Depression \| Mate pāpouri") [Perinatal depression](https://healthify.nz/health-a-z/d/depression-perinatal/ "Perinatal depression") [Antidepressants in pregnancy](https://healthify.nz/medicines-a-z/a/antidepressants-in-pregnancy) [How to support a child or teenager with depression](https://healthify.nz/health-a-z/d/depression-children-and-teenagers/ "How to support a child or teenager with depression") [Depression in later life](https://healthify.nz/health-a-z/d/depression-later-life/ "Depression in later life") [Anxiety \\| Mate māharahara](https://healthify.nz/health-a-z/a/anxiety/ "Anxiety \| Mate māharahara") [Cognitive behavioural therapy (CBT)](https://healthify.nz/health-a-z/c/cognitive-behavioural-therapy) [Nerve pain](https://healthify.nz/health-a-z/n/nerve-pain/ "Nerve pain") [Obsessive compulsive disorder (OCD)](https://healthify.nz/health-a-z/o/obsessive-compulsive-disorder/ "Obsessive compulsive disorder (OCD)") #### More information If you suspect you, or someone you know, might be suffering from depression, read more from our [depression section](https://healthify.nz/health-a-z/d/depression-overview "Depression") or visit [thelowdown.co.nz(external link)](http://thelowdown.co.nz/#/home/ "Open external link") or [depression.org.nz(external link)](http://www.depression.org.nz/ "Open external link") for helpful information, including a self-test. The following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations. [Treatments(external link)](https://depression.org.nz/get-better/treatments/ "Open external link") Depression.org.nz [Antidepressants(external link)](https://www.rcpsych.ac.uk/expertadvice/treatmentswellbeing/antidepressants.aspx "Open external link") Royal College of Psychiatrists, UK [Antidepressants(external link)](https://patient.info/mental-health/depression-leaflet/antidepressants "Open external link") Patient Info, UK [Antidepressants – selecting one that's right for you(external link)](http://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273 "Open external link") Mayo Clinic, US [Depression – treatment options(external link)](https://www.optiongrid.org/option-grids/grid-landing/92/ "Open external link") Option Grid #### Resources [Stopping antidepressants: be cautious and go slow(external link)](https://www.medsafe.govt.nz/Consumers/educational-material/Stopping-Antidepressant-medicines.pdf "Open external link") Medsafe and Ministry of Health, NZ, 2023 [5 questions to ask about your medications(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "Open external link") Health Quality and Safety Commission, NZ, 2019 [English(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "Open external link"), [te reo Māori(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf "Open external link") #### References 1. [The role of medicines in the management of depression in primary care(external link)](https://bpac.org.nz/2021/depression.aspx "Open external link") BPAC, NZ, 2021 2. [Antidepressant drugs(external link)](http://nzf.org.nz/nzf_2225 "Open external link") NZ Formulary ## Brochures ![](https://healthify.nz/assets/Brochures/stopping-antidepressants-be-cautious-and-go-slow-medsafe__ResizedImageWzEwOCwxNTdd.png) [Stopping antidepressants: be cautious and go slow](https://www.medsafe.govt.nz/Consumers/educational-material/Stopping-Antidepressant-medicines.pdf) Medsafe NZ and Ministry of Health, NZ, 2023 ![](https://healthify.nz/assets/Brochures/Healthify-Resources/medicine-side-effects__ResizedImageWzIwMCwxNDBd.jpg) [Medicines and side effects](https://healthify.nz/assets/Brochures/Healthify-Resources/Medicines-side-effects-FINAL.pdf) Healthify He Puna Waiora, NZ, 2024 ![Image not found](https://healthify.nz/assets/5-questions-to-ask-about-your-medications.jpg) 5 questions to ask about your medications Health Quality and Safety Commission, NZ, 2019 [English](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "English") [Te reo Māori](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf "Te reo Māori") ## Free helplines [![Healthline logo](https://healthify.nz/assets/Affiliate-Images/Healthline-Supporters-Block__ResizedImageWzMwMCwxNTBd.png)](https://www.healthy.org.nz/ "Contact Healthline ") [![Text 1737 Helpline logo](https://healthify.nz/assets/Affiliate-Images/Need-to-talk-1737-logo-800x400__ResizedImageWzMwMCwxNTBd.png)](https://1737.org.nz/ "Contact 1737") [![Healthpoint logo](https://healthify.nz/assets/Affiliate-Images/Health-Point-logo__ResizedImageWzMwMCwxNTBd.png)](https://www.healthpoint.co.nz/ "Healthpoint website") [Share on facebook](https://facebook.com/sharer/sharer.php?u=https://healthify.nz/medicines-a-z/a/antidepressants) [Email](https://healthify.nz/cdn-cgi/l/email-protection#407f3335222a2523347d012e342924253032253333212e3433603c600825212c342829263966212d307b222f24397d65700465700165700465700128343430337a6f6f2825212c34282926396e2e3a6f2d25242923292e25336d216d3a6f216f212e342924253032253333212e34336e) [Share on Linked In](https://www.linkedin.com/sharing/share-offsite/?url=https://healthify.nz/medicines-a-z/a/antidepressants) Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust. Reviewed by: Angela Lambie, Pharmacist, Auckland Last reviewed: 16 Oct 2022 Page last updated: 04 Dec 2022 Scan the QR code to view the full page: https://healthify.nz/medicines-a-z/a/antidepressants ![image](https://healthify.nz/assets/Uploads/image.png) [![Healthify He Puna Waiora logo in orange](https://healthify.nz/assets/Affiliate-Images/Healthify-Logo-Orange__ResizedImageWzI1MSwxMjRd.png)](https://healthify.nz/) [![](https://healthify.nz/assets/Affiliate-Images/HNCT-logo-for-footer.jpg)](https://www.hnct.nz/) [![](https://healthify.nz/assets/Affiliate-Images/zerodata-logo-rgb-supplied__ResizedImageWzE1OCw3NV0.jpg)](https://portal.zero.govt.nz/28f2e4000bd5a26366ede8abb548f277 "Link to Healthify using ZeroData") [Home](https://healthify.nz/) [Health A–Z](https://healthify.nz/health-a-z) [Medicines A–Z](https://healthify.nz/medicines-a-z) [Hauora Wellbeing](https://healthify.nz/hauora-wellbeing) [Care & Support](https://healthify.nz/care-and-support) [App Library](https://healthify.nz/app-library) [Tools](https://healthify.nz/tools) [News](https://healthify.nz/news) [Newsletters](https://healthify.nz/newsletters-sign-up "Sign up to our newsletters") [Leave a review](https://socialjuice.io/p/healthify "Link to provide feedback about our site") [About Healthify](https://healthify.nz/about-healthify) [Testimonials](https://healthify.nz/testimonials) [About Health Navigator Charitable Trust](https://www.hnct.nz/) [Volunteer / Work with us](https://healthify.nz/about-healthify/volunteer) [Accessibility](https://healthify.nz/about-healthify/our-policies#accessibility) [Privacy & Cookies Policy](https://healthify.nz/about-healthify/our-policies#privacy-cookies) [Disclaimer](https://healthify.nz/about-healthify/our-policies#disclaimer) [Contact](https://healthify.nz/contact) [Donate](https://donate.healthify.nz/?utm_source=Healthify&utm_medium=footer_link) [For Healthcare Providers](https://healthify.nz/healthcare-providers) [Resources](https://healthify.nz/about-healthify/resources) [Journey to Wellbeing \\| Huarahi Ora](https://www.journeytowellbeing.nz/) [Translations](https://healthify.nz/translations) [Medicine factsheets & videos](https://healthify.nz/medicines-a-z/m/medicine-brand-changes-factsheets-and-videos) [Te Kete Haerenga](https://healthify.nz/tools/t/te-kete-haerenga-wellness-toolkit) [![RNZCGP logo showing endorsement of Healthify](https://healthify.nz/assets/Affiliate-Images/RNZCGP-Endorsed-GUIDANCE-logo-Exp-31-Mar-2027__ResizedImageWzE3MCwxNzBd.png)](https://healthify.nz/about-healthify/why-you-can-trust-us "rnzcgp-endorsement") Scroll to Top [![shielded](https://healthify.nz/_resources/themes/catalyst-starter/dist/img/shielded_site_logo.png?m=1736474156)](https://healthify.nz/medicines-a-z/a/antidepressants) © 2026 Health Navigator Charitable Trust CC36318. 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Readable Markdown	### Key points about antidepressants - Antidepressants are a group of medicines used to treat moderate to severe depression. - Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. - Read about how to take antidepressants safely and possible side effects. ![HN 0789 female pharmacist working in dispensary of community pharmacy 1](https://healthify.nz/assets/Health-A-Z/Medicines/HN-0789-female-pharmacist-working-in-dispensary-of-community-pharmacy-1.jpg) Antidepressants are medicines that are mainly used to treat moderate to severe depression. They can help improve mood and increase motivation for people who may have lost interest in activities they once enjoyed. They can also help with sleep, thinking and concentration. Antidepressants work best when they are used together with psychological therapies, like CBT (cognitive behavioural therapy) and lifestyle changes. Read more about [treating depression](https://healthify.nz/health-a-z/d/depression-overview). Antidepressants are not usually needed, and are often not very effective for mild depression. [CBT](https://healthify.nz/health-a-z/c/cognitive-behavioural-therapy), talking therapy and regular exercise work better for mild depression. Antidepressants are also used to treat other conditions such as [generalised anxiety disorder (GAD)](https://healthify.nz/health-a-z/a/anxiety "Anxiety"), [eating disorders](https://healthify.nz/health-a-z/e/eating-disorders "Eating disorders"), [obsessive-compulsive disorder](https://healthify.nz/health-a-z/o/obsessive-compulsive-disorder "Obsessive compulsive disorder") and [post-traumatic stress disorder](https://healthify.nz/health-a-z/p/post-traumatic-stress-disorder-ptsd "Post-traumatic stress disorder (PTSD)"). They are also sometimes used to treat people with long-term (chronic) pain. ![Young man talking to GP ](https://healthify.nz/assets/Card-Images/woman-talking-to-gp-665x443-1-v2.jpg) Image credit: 123RF If you need help or want to talk to somebody about your mental health, you can get support from any of the following: - Free call or text 1737 any time for support from a trained counsellor - Lifeline 0800 543 354 (0800 LIFELINE) or free text 4357 (HELP) - Suicide Crisis Helpline 0508 828 865 (0508 TAUTOKO) - Healthline 0800 611 116 - Samaritans 0800 726 666. There are many types of antidepressants. Different medicines suit different people. The choice of antidepressant medicine will depend on: - the severity and type of your illness - whether you have other medical conditions - other medicines you might be taking - your response to antidepressant medicines in the past - possible side effects. \| Antidepressants available in Aotearoa New Zealand \| \|---\| \| Selective serotonin reuptake inhibitors (SSRIs) Examples include [fluoxetine](https://healthify.nz/medicines-a-z/f/fluoxetine "Fluoxetine"), [sertraline](https://healthify.nz/medicines-a-z/s/sertraline "Sertraline"), [paroxetine](https://healthify.nz/medicines-a-z/p/paroxetine "Paroxetine"), [citalopram](https://healthify.nz/medicines-a-z/c/citalopram "Citalopram") and [escitalopram](https://healthify.nz/medicines-a-z/e/escitalopram "Escitalopram"). SSRIs are usually the preferred antidepressant for moderate to severe depression. Overall they have fewer side effects than the other types of antidepressants. Read more about [SSRIs.](https://healthify.nz/medicines-a-z/s/ssri-antidepressants "SSRI antidepressants") \| \| Serotonin and noradrenaline reuptake inhibitors (SNRIs) An example is [venlafaxine.](https://healthify.nz/medicines-a-z/v/venlafaxine "Venlafaxine") Venlafaxine is often used when SSRIs haven't been successful. \| \| Tricyclic antidepressants (TCAs) Examples include [amitriptyline](https://healthify.nz/medicines-a-z/a/amitriptyline "Amitriptyline"), clomipramine, dosulepin, [imipramine](https://healthify.nz/medicines-a-z/i/imipramine "Imipramine"), and nortriptyline. TCAs aren't usually used for their antidepressant effects due to their side effects. They're most often used for other conditions such as [neuropathic pain](https://healthify.nz/health-a-z/n/nerve-pain "Nerve pain") and anxiety. \| \| Monoamine-oxidase inhibitors Examples are moclobemide and tranylcypromine. MAOIs are rarely used due to their side effects and the number of interactions with medicines and foods. \| \| Other antidepressants [Mirtazapine](https://healthify.nz/medicines-a-z/m/mirtazapine "Mirtazapine") \| Some people find that herbal products like [St John's Wort](https://healthify.nz/medicines-a-z/s/st-john-s-wort "St John’s wort") can be useful for depression but it can interact with antidepressant medicines and other medicines. Before taking herbal supplements, ask your doctor or pharmacist if they interact with the medicine you are taking. We don't know for certain, but researchers think that antidepressants work by increasing the activity of certain chemicals working in our brains called neurotransmitters. Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion. While depression is not simply a deficiency of these chemicals, we do know that antidepressant medications help to relieve symptoms of depression and anxiety in about 50–70% of people who try them. Some people will respond to one antidepressant better than another so changes may be needed to find the best type and dose of medicine for you. Neurotransmitters may also affect pain signals sent by nerves, which would explain why some antidepressants can help relieve long-term pain. Antidepressant medicines work best if you take them every day. When you first start taking an antidepressant medicine, you won’t feel better straight away. Most people start to feel better after taking them for 2 to 4 weeks. However, it can take up to 6 to 8 weeks for them to really work. How long you need to take antidepressants for will depend on a number of factors and is best discussed with your doctor. Most people will need to take these medicines for at least 6 to 12 months. If you stop taking it too early, your signs of depression or anxiety may come back. During the first few months of treatment, you'll usually see your doctor or a specialist nurse at least once every few weeks to see how well the medicine is working. If you're ready to come off your antidepressant medicine, or think it isn't working for you, don't stop taking it suddenly. The dose of these medicines should be slowly reduced over 4 weeks or more. - Some people get withdrawal symptoms when they try to reduce or stop taking an antidepressant. - Withdrawal symptoms can be different for everyone. They usually come on within 5 days of stopping the medicine and generally last 1 to 2 weeks. Some people have severe withdrawal symptoms that last for several months or more. - If you have taken a high dose of antidepressants for a long time you are more likely to have withdrawal symptoms. Some antidepressants are more likely to cause withdrawal symptoms, eg, amitriptyline, clomipramine, paroxetine and venlafaxine. Talk to your doctor about how to stop taking your medicine slowly. They will work out a plan with you. They will slowly lower the amount you take over several weeks until you’re not taking it at all. This lowers the chance of getting withdrawal symptoms as you stop taking it. Withdrawal may include feeling dizzy, tired or worried, or having trouble sleeping. Read more about [stopping antidepressants.(external link)](https://www.medsafe.govt.nz/Consumers/educational-material/Stopping-Antidepressant-medicines.pdf "Open external link") Talk to your doctor or your healthcare team if you are stopping your medicine and feel like you might harm yourself or others, or if your low mood or anxiety returns. Like all medicines antidepressants can cause side effects but not everyone gets them. Different antidepressants have different side effects. Most side effects are mild and go away after a few weeks as your body gets used to the medicine. Examples include having trouble sleeping (insomnia), feeling like you might throw up (nausea) and feeling dizzy. At the start of treatment some people can experience side effects such as agitation and anxiety, especially in the first few weeks. Keep in mind that things will get better and these side effects are likely to pass as your body gets used to the new medicine. Talk to your healthcare provider about what you can do if side effects are a problem or if you think you might harm yourself or others. They may suggest taking a smaller dose (amount) or trying a different medicine. Read more about [medicines and side effects](https://healthify.nz/medicines-a-z/s/side-effects-medicines) and [reporting a reaction you think might be a side effect](https://healthify.nz/medicines-a-z/s/side-effects-reporting). If you suspect you, or someone you know, might be suffering from depression, read more from our [depression section](https://healthify.nz/health-a-z/d/depression-overview "Depression") or visit [thelowdown.co.nz(external link)](http://thelowdown.co.nz/#/home/ "Open external link") or [depression.org.nz(external link)](http://www.depression.org.nz/ "Open external link") for helpful information, including a self-test. The following links provide further information on antidepressants. Be aware websites from other countries may contain information that differs from Aotearoa New Zealand recommendations. [Treatments(external link)](https://depression.org.nz/get-better/treatments/ "Open external link") Depression.org.nz [Antidepressants(external link)](https://www.rcpsych.ac.uk/expertadvice/treatmentswellbeing/antidepressants.aspx "Open external link") Royal College of Psychiatrists, UK [Antidepressants(external link)](https://patient.info/mental-health/depression-leaflet/antidepressants "Open external link") Patient Info, UK [Antidepressants – selecting one that's right for you(external link)](http://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273 "Open external link") Mayo Clinic, US [Depression – treatment options(external link)](https://www.optiongrid.org/option-grids/grid-landing/92/ "Open external link") Option Grid #### Resources [Stopping antidepressants: be cautious and go slow(external link)](https://www.medsafe.govt.nz/Consumers/educational-material/Stopping-Antidepressant-medicines.pdf "Open external link") Medsafe and Ministry of Health, NZ, 2023 [5 questions to ask about your medications(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "Open external link") Health Quality and Safety Commission, NZ, 2019 [English(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "Open external link"), [te reo Māori(external link)](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf "Open external link") #### References 1. [The role of medicines in the management of depression in primary care(external link)](https://bpac.org.nz/2021/depression.aspx "Open external link") BPAC, NZ, 2021 2. [Antidepressant drugs(external link)](http://nzf.org.nz/nzf_2225 "Open external link") NZ Formulary Brochures ![Image not found](https://healthify.nz/assets/5-questions-to-ask-about-your-medications.jpg) 5 questions to ask about your medications Health Quality and Safety Commission, NZ, 2019 [English](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-EN-Jan-2019.pdf "English") [Te reo Māori](https://www.hqsc.govt.nz/assets/Our-work/System-safety/Reducing-harm/Medicines/Publications-resources/5-questions-to-ask-about-your-medications-poster-Maori-Jan-2019.pdf "Te reo Māori") Free helplines [![Healthline logo](https://healthify.nz/assets/Affiliate-Images/Healthline-Supporters-Block__ResizedImageWzMwMCwxNTBd.png)](https://www.healthy.org.nz/ "Contact Healthline ") [![Text 1737 Helpline logo](https://healthify.nz/assets/Affiliate-Images/Need-to-talk-1737-logo-800x400__ResizedImageWzMwMCwxNTBd.png)](https://1737.org.nz/ "Contact 1737") [![Healthpoint logo](https://healthify.nz/assets/Affiliate-Images/Health-Point-logo__ResizedImageWzMwMCwxNTBd.png)](https://www.healthpoint.co.nz/ "Healthpoint website") Credits: Sandra Ponen, Pharmacist, Healthify He Puna Waiora. Healthify is brought to you by Health Navigator Charitable Trust. Reviewed by: Angela Lambie, Pharmacist, Auckland Last reviewed: 16 Oct 2022 Page last updated: 04 Dec 2022
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