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URLhttps://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/
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Meta TitleMelatonin side effects: What are the risks? | Psychlinks Forum -- Archive Only (2004-2022)
Meta DescriptionMelatonin side effects: What are the risks? by Brent A. Bauer, M.D., Mayo Clinic Oct. 20, 2011 Is melatonin a helpful sleep aid - and what should I know...
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Articles Forum Archive Medication Issues Alternative Medicine & Therapies - Natural Remedies More threads by David Baxter PhD #1 Melatonin side effects: What are the risks? by Brent A. Bauer, M.D., Mayo Clinic Oct. 20, 2011 Is melatonin a helpful sleep aid - and what should I know about melatonin side effects? Answer The hormone melatonin helps control your natural sleep-wake cycle. Natural levels of melatonin in the blood are highest at night. Some research suggests that melatonin supplements might be helpful in treating jet lag or reducing the time it takes to fall asleep - although the effect is typically mild. Melatonin might be more effective for other types of sleep issues, such as delayed sleep disorder or sleep disorders affecting circadian rhythm. The most common melatonin side effects include: Daytime sleepiness Dizziness Headaches Other, less common melatonin side effects might include abdominal discomfort, mild anxiety, irritability, confusion and short-lasting feelings of depression. In addition, melatonin supplements can interact with various medications, including: Blood-thinning medications (anticoagulants) Medications that suppress the immune system (immunosuppressants) Diabetes medications Birth control pills If you're considering taking melatonin supplements, check with your doctor first - especially if you have any health conditions. The correct dose depends on the intended use. For example, circadian rhythm sleep disorders are often treated with 0.5 milligrams of melatonin a day, while doses of 3 to 5 milligrams a day might be used to treat jet lag or reduce the time it takes to fall asleep. In addition, remember that melatonin is generally recommended only for short-term use - up to two months. Some research indicates that longer term use might be appropriate in certain cases, however. If you take melatonin, choose commercial supplements produced in a lab. Melatonin supplements made from animal sources might contain various contaminants. Don't engage in activities that require alertness - such as driving or operating heavy machinery - for four to five hours after taking melatonin. References Melatonin. Natural Medicines Comprehensive Database. Welcome to the Natural Medicines Research Collaboration . Accessed July 18, 2011. Wade AG, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: A randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Medicine. 2010;8:51. Van Geijlswijk IM, et al. The use of exogenous melatonin in delayed sleep phase disorder: A meta-analysis. Sleep. 2010;33:1605. Wade AG, et al. Prolonged release melatonin in the treatment of primary insomnia: Evaluation of the age cut-off for short- and long-term response. Current Medical Research and Opinion. 2011;27:87. Ferguson SA, et al. Melatonin agonists and insomnia. Expert Review of Neurotherapeutics. 2010;10:305. Morgenthaler TI, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. Sleep. 2007;30:1445. Articles Forum Archive Medication Issues Alternative Medicine & Therapies - Natural Remedies
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For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly. You should upgrade or use an [alternative browser](https://www.google.com/chrome/). # [Melatonin side effects: What are the risks?](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/) - [Thread starter](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/) [David Baxter PhD](https://forum.psychlinks.ca/members/david-baxter-phd.1/) - Start date [Aug 21, 2013](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/) [More threads by David Baxter PhD](https://forum.psychlinks.ca/morethreads/?t=26331) - [Aug 21, 2013](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/post-200927) - [\#1](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/post-200927) [![David Baxter PhD](https://forum.psychlinks.ca/data/avatars/m/0/1.jpg?1645098814)](https://forum.psychlinks.ca/members/david-baxter-phd.1/) #### [David Baxter PhD](https://forum.psychlinks.ca/members/david-baxter-phd.1/) ##### Late Founder [**Melatonin side effects: What are the risks?**](https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/melatonin-side-effects/faq-20057874) by Brent A. Bauer, M.D., Mayo Clinic Oct. 20, 2011 ***Is melatonin a helpful sleep aid - and what should I know about melatonin side effects?*** **Answer** The hormone melatonin helps control your natural sleep-wake cycle. Natural levels of melatonin in the blood are highest at night. Some research suggests that melatonin supplements might be helpful in treating jet lag or reducing the time it takes to fall asleep - although the effect is typically mild. Melatonin might be more effective for other types of sleep issues, such as delayed sleep disorder or sleep disorders affecting circadian rhythm. The most common melatonin side effects include: - Daytime sleepiness - Dizziness - Headaches Other, less common melatonin side effects might include abdominal discomfort, mild anxiety, irritability, confusion and short-lasting feelings of depression. In addition, melatonin supplements can interact with various medications, including: - Blood-thinning medications (anticoagulants) - Medications that suppress the immune system (immunosuppressants) - Diabetes medications - Birth control pills If you're considering taking melatonin supplements, check with your doctor first - especially if you have any health conditions. The correct dose depends on the intended use. For example, circadian rhythm sleep disorders are often treated with 0.5 milligrams of melatonin a day, while doses of 3 to 5 milligrams a day might be used to treat jet lag or reduce the time it takes to fall asleep. In addition, remember that melatonin is generally recommended only for short-term use - up to two months. Some research indicates that longer term use might be appropriate in certain cases, however. If you take melatonin, choose commercial supplements produced in a lab. Melatonin supplements made from animal sources might contain various contaminants. Don't engage in activities that require alertness - such as driving or operating heavy machinery - for four to five hours after taking melatonin. **References** 1. Melatonin. Natural Medicines Comprehensive Database. [Welcome to the Natural Medicines Research Collaboration](http://www.naturaldatabase.com/). Accessed July 18, 2011. 2. Wade AG, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: A randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Medicine. 2010;8:51. 3. Van Geijlswijk IM, et al. The use of exogenous melatonin in delayed sleep phase disorder: A meta-analysis. Sleep. 2010;33:1605. 4. Wade AG, et al. Prolonged release melatonin in the treatment of primary insomnia: Evaluation of the age cut-off for short- and long-term response. Current Medical Research and Opinion. 2011;27:87. 5. Ferguson SA, et al. Melatonin agonists and insomnia. Expert Review of Neurotherapeutics. 2010;10:305. 6. Morgenthaler TI, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. Sleep. 2007;30:1445. Replying is not possible. This forum is only available as an [archive](https://forum.psychlinks.ca/threads/permanent-archive.31765/). ### Similar threads [![David Baxter PhD](https://forum.psychlinks.ca/data/avatars/s/0/1.jpg?1645098814)](https://forum.psychlinks.ca/members/david-baxter-phd.1/) [Melatonin side effects: What are the risks?](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.7353/) - [David Baxter PhD](https://forum.psychlinks.ca/members/david-baxter-phd.1/) - [Oct 25, 2007](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.7353/) - [Sleep, Dreams, Insomnia](https://forum.psychlinks.ca/forums/sleep-dreams-insomnia.62/) Replies 4 Views 49K [Sep 12, 2012](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.7353/latest) [Darkside](https://forum.psychlinks.ca/members/darkside.4767/) [D](https://forum.psychlinks.ca/members/darkside.4767/) [![David Baxter PhD](https://forum.psychlinks.ca/data/avatars/s/0/1.jpg?1645098814)](https://forum.psychlinks.ca/members/david-baxter-phd.1/) [Young Children Increasingly Ingest Melatonin With Serious Outcomes](https://forum.psychlinks.ca/threads/young-children-increasingly-ingest-melatonin-with-serious-outcomes.31485/) - 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[![Psychlinks Forum -- Archive Only (2004-2022)](https://forum.psychlinks.ca/data/assets/logo/psychlinks-stonehenge-522x164.jpg)](https://forum.psychlinks.ca/ams/) [![Psychlinks Forum -- Archive Only (2004-2022)](https://forum.psychlinks.ca/data/assets/logo/psychlinks-stonehenge-522x164.jpg)](https://forum.psychlinks.ca/ams/) - [Articles](https://forum.psychlinks.ca/ams/) - [Forum Archive](https://forum.psychlinks.ca/) - [Medication Issues](https://forum.psychlinks.ca/#medication-issues.69) - [Alternative Medicine & Therapies - Natural Remedies](https://forum.psychlinks.ca/forums/alternative-medicine-therapies-natural-remedies.76/) [More threads by David Baxter PhD](https://forum.psychlinks.ca/morethreads/?t=26331) - [\#1](https://forum.psychlinks.ca/threads/melatonin-side-effects-what-are-the-risks.26331/post-200927) [![David Baxter PhD](https://forum.psychlinks.ca/data/avatars/m/0/1.jpg?1645098814)](https://forum.psychlinks.ca/members/david-baxter-phd.1/) [**Melatonin side effects: What are the risks?**](https://www.mayoclinic.org/healthy-lifestyle/adult-health/expert-answers/melatonin-side-effects/faq-20057874) by Brent A. Bauer, M.D., Mayo Clinic Oct. 20, 2011 ***Is melatonin a helpful sleep aid - and what should I know about melatonin side effects?*** **Answer** The hormone melatonin helps control your natural sleep-wake cycle. Natural levels of melatonin in the blood are highest at night. Some research suggests that melatonin supplements might be helpful in treating jet lag or reducing the time it takes to fall asleep - although the effect is typically mild. Melatonin might be more effective for other types of sleep issues, such as delayed sleep disorder or sleep disorders affecting circadian rhythm. The most common melatonin side effects include: - Daytime sleepiness - Dizziness - Headaches Other, less common melatonin side effects might include abdominal discomfort, mild anxiety, irritability, confusion and short-lasting feelings of depression. In addition, melatonin supplements can interact with various medications, including: - Blood-thinning medications (anticoagulants) - Medications that suppress the immune system (immunosuppressants) - Diabetes medications - Birth control pills If you're considering taking melatonin supplements, check with your doctor first - especially if you have any health conditions. The correct dose depends on the intended use. For example, circadian rhythm sleep disorders are often treated with 0.5 milligrams of melatonin a day, while doses of 3 to 5 milligrams a day might be used to treat jet lag or reduce the time it takes to fall asleep. In addition, remember that melatonin is generally recommended only for short-term use - up to two months. Some research indicates that longer term use might be appropriate in certain cases, however. If you take melatonin, choose commercial supplements produced in a lab. Melatonin supplements made from animal sources might contain various contaminants. Don't engage in activities that require alertness - such as driving or operating heavy machinery - for four to five hours after taking melatonin. **References** 1. Melatonin. Natural Medicines Comprehensive Database. [Welcome to the Natural Medicines Research Collaboration](http://www.naturaldatabase.com/). Accessed July 18, 2011. 2. Wade AG, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: A randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Medicine. 2010;8:51. 3. Van Geijlswijk IM, et al. The use of exogenous melatonin in delayed sleep phase disorder: A meta-analysis. Sleep. 2010;33:1605. 4. Wade AG, et al. Prolonged release melatonin in the treatment of primary insomnia: Evaluation of the age cut-off for short- and long-term response. Current Medical Research and Opinion. 2011;27:87. 5. Ferguson SA, et al. Melatonin agonists and insomnia. Expert Review of Neurotherapeutics. 2010;10:305. 6. Morgenthaler TI, et al. Practice parameters for the clinical evaluation and treatment of circadian rhythm sleep disorders. Sleep. 2007;30:1445. - [Articles](https://forum.psychlinks.ca/ams/) - [Forum Archive](https://forum.psychlinks.ca/) - [Medication Issues](https://forum.psychlinks.ca/#medication-issues.69) - [Alternative Medicine & Therapies - Natural Remedies](https://forum.psychlinks.ca/forums/alternative-medicine-therapies-natural-remedies.76/)
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