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URLhttps://en.wikipedia.org/wiki/Human_body_temperature
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Normal human body temperature ( normothermia , euthermia ) is the typical temperature range found in humans . The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F). [ 8 ] [ 9 ] Human body temperature varies. It depends on sex, age, time of day, exertion level, health status (such as illness and menstruation), what part of the body the measurement is taken at, state of consciousness (waking, sleeping, sedated), and emotions. Body temperature is kept in the normal range by a homeostatic function known as thermoregulation , in which adjustment of temperature is triggered by the central nervous system . Methods of measurement [ edit ] A medical thermometer showing a temperature reading of 38.7 °C (101.7 °F) Taking a human's temperature is an initial part of a full clinical examination . There are various types of medical thermometers , as well as sites used for measurement, including: Under the armpit (axillary temperature) In the mouth (oral temperature) In the rectum (rectal temperature) In the ear (tympanic temperature) On the skin of the forehead over the temporal artery Using heat flux sensors Diurnal variation in body temperature, ranging from about 37.5 °C (99.5 °F) from 10 a.m. to 6 p.m., and falling to about 36.4 °C (97.5 °F) from 2 a.m. to 6 a.m. (Based on figure in entry for 'Animal Heat' in 11th edition of the Encyclopædia Britannica , 1910) Temperature control ( thermoregulation ) is a homeostatic mechanism that keeps the organism at optimum operating temperature , as the temperature affects the rate of chemical reactions . In humans , the average internal temperature is widely accepted to be 37 °C (98.6 °F), a "normal" temperature established in the 1800s. But newer studies show that average internal temperature for men and women is 36.4 °C (97.5 °F). [ 10 ] No person always has exactly the same temperature at every moment of the day. Temperatures cycle regularly up and down through the day, as controlled by the person's circadian rhythm . The lowest temperature occurs about two hours before the person normally wakes up. Additionally, temperatures change according to activities and external factors. [ 11 ] In addition to varying throughout the day, normal body temperature may also differ as much as 0.5 °C (0.90 °F) from one day to the next, so that the highest or lowest temperatures on one day will not always exactly match the highest or lowest temperatures on the next day. Normal human body temperature varies slightly from person to person and by the time of day. Consequently, each type of measurement has a range of normal temperatures. The range for normal human body temperatures, taken orally, is 36.8 ± 0.5 °C (98.2 ± 0.9 °F). [ 12 ] This means that any oral temperature between 36.3 and 37.3 °C (97.3 and 99.1 °F) is likely to be normal. [ 13 ] The normal human body temperature is often stated as 36.5–37.5 °C (97.7–99.5 °F). [ 8 ] [ 9 ] In adults a review of the literature has found a wider range of 33.2–38.2 °C (91.8–100.8 °F) for normal temperatures, depending on the gender and location measured. [ 14 ] Reported values vary depending on how it is measured: oral (under the tongue): 36.8 ± 0.4 °C (98.2 ± 0.7 °F), [ 15 ] internal ( rectal , vaginal ): 37.0 °C (98.6 °F). [ 15 ] A rectal or vaginal measurement taken directly inside the body cavity is typically slightly higher than oral measurement, and oral measurement is somewhat higher than skin measurement. Other places, such as under the arm or in the ear, produce different typical temperatures. [ 15 ] While some people think of these averages as representing normal or ideal measurements, a wide range of temperatures has been found in healthy people. [ 5 ] The body temperature of a healthy person varies during the day by about 0.5 °C (0.9 °F) with lower temperatures in the morning and higher temperatures in the late afternoon and evening, as the body's needs and activities change. [ 15 ] Other circumstances also affect the body's temperature. The core body temperature of an individual tends to have the lowest value in the second half of the sleep cycle; the lowest point, called the nadir , is one of the primary markers for circadian rhythms . The body temperature also changes when a person is hungry, sleepy, sick, or cold. Body temperature normally fluctuates over the day following circadian rhythms , with the lowest levels around 4   a.m. and the highest in the late afternoon, between 4:00 and 6:00 p.m. (assuming the person sleeps at night and stays awake during the day). [ 12 ] [ 15 ] Therefore, an oral temperature of 37.3 °C (99.1 °F) would, strictly speaking, be a normal, healthy temperature in the afternoon but not in the early morning. [ 15 ] An individual's body temperature typically changes by about 0.5 °C (0.9 °F) between its highest and lowest points each day. [ 15 ] Body temperature is sensitive to many hormones, so women have a temperature rhythm that varies with the menstrual cycle , called a circamensal rhythm. [ 11 ] [ unreliable medical source? ] A woman's basal body temperature rises sharply after ovulation , as estrogen production decreases and progesterone increases. Fertility awareness programs use this change to identify when a woman has ovulated to achieve or avoid pregnancy . During the luteal phase of the menstrual cycle, both the lowest and the average temperatures are slightly higher than during other parts of the cycle. However, the amount that the temperature rises during each day is slightly lower than typical, so the highest temperature of the day is not very much higher than usual. [ 16 ] [ unreliable medical source? ] Hormonal contraceptives both suppress the circamensal rhythm and raise the typical body temperature by about 0.6 °C (1.1 °F). [ 11 ] [ unreliable medical source? ] Temperature also may vary with the change of seasons during each year. This pattern is called a circannual rhythm. [ 16 ] [ unreliable medical source? ] Studies of seasonal variations have produced inconsistent results. People living in different climates may have different seasonal patterns. [ citation needed ] It has been found that physically active individuals have larger changes in body temperature throughout the day. Physically active people have been reported to have lower body temperatures than their less active peers in the early morning and similar or higher body temperatures later in the day. [ 17 ] With increased age, both average body temperature and the amount of daily variability in the body temperature tend to decrease. [ 16 ] [ unreliable medical source? ] Elderly people may have a decreased ability to generate body heat during a fever, so even a somewhat elevated temperature can indicate a serious underlying cause in geriatrics . One study suggested that the average body temperature has also decreased since the 1850s. [ 18 ] The study's authors believe the most likely explanation for the change is a reduction in inflammation at the population level due to decreased chronic infections and improved hygiene. [ 19 ] Measurement methods [ edit ] Temperature by measurement technique [ 14 ] Method Women Men Oral 33.2–38.1 °C (91.8–100.6 °F) 35.7–37.7 °C (96.3–99.9 °F) Rectal 36.8–37.1 °C (98.2–98.8 °F) 36.7–37.5 °C (98.1–99.5 °F) Tympanic 35.7–37.5 °C (96.3–99.5 °F) 35.5–37.5 °C (95.9–99.5 °F) Axillary 35.5–37.0 °C (95.9–98.6 °F) Different methods used for measuring temperature produce different results. The temperature reading depends on which part of the body is being measured. The typical daytime temperatures among healthy adults are as follows: Temperature in the rectum (rectal), vagina, or in the ear (tympanic) is about 37.5 °C (99.5 °F) [ 20 ] [ medical citation needed ] Temperature in the mouth (oral) is about 36.8 °C (98.2 °F) [ 12 ] Temperature under the arm (axillary) is about 36.5 °C (97.7 °F) [ 20 ] [ medical citation needed ] Generally, oral, rectal, gut, and core body temperatures, although slightly different, are well-correlated. [ citation needed ] Oral temperatures are influenced by drinking, chewing, smoking, and breathing with the mouth open. Mouth breathing , cold drinks or food reduce oral temperatures; hot drinks, hot food, chewing, and smoking raise oral temperatures. [ 21 ] Each measurement method also has different normal ranges depending on sex. [ 14 ] Infrared thermometer [ edit ] As of 2016, reviews of infrared thermometers have found them to be of variable accuracy. [ 22 ] This includes tympanic infrared thermometers in children. [ 23 ] Variations due to outside factors [ edit ] Sleep disturbances also affect temperatures. Normally, body temperature drops significantly at a person's normal bedtime and throughout the night. Short-term sleep deprivation produces a higher temperature at night than normal, but long-term sleep deprivation appears to reduce temperatures. [ 24 ] Insomnia and poor sleep quality are associated with smaller and later drops in body temperature. [ 25 ] Similarly, waking up unusually early, sleeping in, jet lag and changes to shift work schedules may affect body temperature. A temperature setpoint is the level at which the body attempts to maintain its temperature. When the setpoint is raised, the result is a fever. Most fevers are caused by infectious disease and can be lowered, if desired, with antipyretic medications. An early morning temperature higher than 37.3 °C (99.1 °F) or a late afternoon temperature higher than 37.7 °C (99.9 °F) is normally considered a fever, assuming that the temperature is elevated due to a change in the hypothalamus's setpoint. [ 15 ] Lower thresholds are sometimes appropriate for elderly people. [ 15 ] The normal daily temperature variation is typically 0.5 °C (0.90 °F), but can be greater among people recovering from a fever. [ 15 ] An organism at optimum temperature is considered afebrile , meaning " without fever ". [ 26 ] If temperature is raised, but the setpoint is not raised, then the result is hyperthermia . Hyperthermia occurs when the body produces or absorbs more heat than it can dissipate. It is usually caused by prolonged exposure to high temperatures. The heat-regulating mechanisms of the body eventually become overwhelmed and unable to deal effectively with the heat, causing the body temperature to climb uncontrollably. Hyperthermia at or above about 40 °C (104 °F) is a life-threatening medical emergency that requires immediate treatment. Common symptoms include headache, confusion, and fatigue. If sweating has resulted in dehydration, then the affected person may have dry, red skin. In a medical setting, mild hyperthermia is commonly called heat exhaustion or heat prostration ; severe hyperthermia is called heat stroke . Heatstroke may come on suddenly, but it usually follows the untreated milder stages. Treatment involves cooling and rehydrating the body; fever-reducing drugs are useless for this condition. This may be done by moving out of direct sunlight to a cooler and shaded environment, drinking water, removing clothing that might keep heat close to the body, or sitting in front of a fan. Bathing in tepid or cool water, or even just washing the face and other exposed areas of the skin, can be helpful. With fever, the body's core temperature rises to a higher temperature through the action of the part of the brain that controls the body temperature; with hyperthermia, the body temperature is raised without the influence of the heat control centers. In hypothermia, body temperature drops below that required for normal metabolism and bodily functions. In humans, this is usually due to excessive exposure to cold air or water, but it can be deliberately induced as a medical treatment . Symptoms usually appear when the body's core temperature drops by 1–2 °C (1.8–3.6 °F) below normal temperature. Basal body temperature [ edit ] Basal body temperature is the lowest temperature attained by the body during rest (usually during sleep). It is generally measured immediately after awakening and before any physical activity has been undertaken, although the temperature measured at that time is somewhat higher than the true basal body temperature. In women, temperature differs at various points in the menstrual cycle , and this can be used in the long term to track ovulation both to aid conception or avoid pregnancy. This process is called fertility awareness . Core temperature, also called core body temperature, is the operating temperature of an organism , specifically in deep structures of the body such as the liver , in comparison to temperatures of peripheral tissues. Core temperature is normally maintained within a narrow range so that essential enzymatic reactions can occur. Significant core temperature elevation ( hyperthermia ) or depression ( hypothermia ) over more than a brief period of time is fatal. Temperature examination in the heart , using a catheter, is the traditional gold standard measurement used to estimate core temperature (oral temperature is affected by hot or cold drinks, ambient temperature fluctuations as well as mouth-breathing). Since catheters are highly invasive, the generally accepted alternative for measuring core body temperature is through rectal measurements. Rectal temperature is expected to be approximately 1 °F (0.56 °C) higher than an oral temperature taken on the same person at the same time. Ear thermometers measure temperature from the tympanic membrane using infrared sensors and also aim to measure core body temperature, since the blood supply of this membrane is directly shared with the brain . However, this method of measuring body temperature is not as accurate as rectal measurement and has a low sensitivity for fever, failing to determine three or four out of every ten fever measurements in children. [ 27 ] Ear temperature measurement may be acceptable for observing trends in body temperature but is less useful in consistently identifying and diagnosing fever. Until recently, direct measurement of core body temperature required either an ingestible device or surgical insertion of a probe. Therefore, a variety of indirect methods have commonly been used as the preferred alternative to these more accurate albeit more invasive methods. The rectal or vaginal temperature is generally considered to give the most accurate assessment of core body temperature, particularly in hypothermia. In the early 2000s, ingestible thermistors in capsule form were produced, allowing the temperature inside the digestive tract to be transmitted to an external receiver; one study found that these were comparable in accuracy to rectal temperature measurement. [ 28 ] More recently, a new method using heat flux sensors have been developed. Several research papers show that its accuracy is similar to the invasive methods. [ 29 ] [ 30 ] [ 31 ] Measurement within the body finds internal variation temperatures as different as 21.5 °C (70.7 °F) for the radial artery and 31.1 °C (88.0 °F) for the brachial artery . [ 32 ] It has been observed that "chaos" has been "introduced into physiology by the fictitious assumption of a constant blood temperature". [ 32 ] Temperature variation [ edit ] 44 °C (111.2 °F) or more – Almost certainly death will occur; however, people have been known to survive up to 46.5 °C (115.7 °F). [ 33 ] [ 34 ] 43 °C (109.4 °F) – Normally death, or there may be serious brain damage, convulsions, and shock. Cardio-respiratory collapse will likely occur. 42 °C (107.6 °F) – Subject may turn red. They may become comatose, be in severe delirium, and convulsions can occur. 41 °C (105.8 °F) – ( Medical emergency ) – Fainting, severe headache, dizziness, confusion, hallucinations, delirium, and drowsiness can occur. There may also be palpitations and breathlessness. 40 °C (104 °F) – Fainting, dehydration, weakness, headache, breathlessness, and dizziness may occur as well as profuse sweating. 39 °C (102.2 °F) – Severe sweating, and red. Fast heart rate and breathlessness. There may be exhaustion accompanying this. Children and people with epilepsy may suffer convulsions at this temperature. 38 °C (100.4 °F) – (Classed as hyperthermia if not caused by a fever ) – Feeling hot, sweating, feeling thirsty, feeling very uncomfortable. 37.6 °C (99.7 °F) — Classed as a slight fever. May lose appetite, feeling hot, feeling uncomfortable, feeling thirsty. 36.5–37.5 °C (97.7–99.5 °F) is a typically reported range for normal body temperature. [ 8 ] 35.5 °C (95.9 °F) – Feeling cold, mild to moderate shivering. This can be a normal body temperature for sleeping. 35 °C (95 °F) – Threshold for hypothermia . Intense shivering, numbness and bluish/grayness of the skin. There is the possibility of heart irritability. 34 °C (93.2 °F) – Severe shivering, loss of movement of fingers, blueness, and confusion. Some behavioral changes may take place. 33 °C (91.4 °F) – Moderate to severe confusion, sleepiness, depressed reflexes, progressive loss of shivering, slow heartbeat, shallow breathing. Shivering may stop. The subject may be unresponsive to certain stimuli. 32 °C (89.6 °F) – ( Medical emergency ) – Hallucinations, delirium, complete confusion, extreme sleepiness that is progressively becoming comatose. Shivering is absent. Reflex may be absent or very slight. 31 °C (87.8 °F) – Comatose, very rarely conscious. No or slight reflexes. Very shallow breathing and slow heart rate. Possibility of serious heart rhythm problems. 28 °C (82.4 °F) – Severe heart rhythm disturbances are likely and breathing may stop at any time. The person may appear to be dead. [ citation needed ] 24–26 °C (75.2–78.8 °F) or less – Death usually occurs due to irregular heart beat or respiratory arrest; however, some patients have been known to survive with body temperatures lower than 12.7 °C (54.9 °F). [ 35 ] The lowest recorded core temperature from a patient with accidental hypothermia who survived without neurological sequelae is 11.8 °C (53.2 °F). [ 36 ] There are non-verbal corporal cues that can hint at an individual experiencing a low body temperature, which can be used for those with dysphasia or infants. [ 37 ] Examples of non- verbal cues of coldness include stillness and being lethargic, unusual paleness of skin among light-skinned people, and, among males, shrinkage, and contraction of the scrotum . [ 38 ] Effect of environment [ edit ] Environmental conditions, primarily temperature and humidity, affect the ability of the mammalian body to thermoregulate. The psychrometric temperature , of which the wet-bulb temperature is the main component, largely limits thermoregulation. It was thought that a wet-bulb temperature of about 35 °C (95 °F) was the highest sustained value consistent with human life. A 2022 study on the effect of heat on young people found that the critical wet-bulb temperature at which heat stress can no longer be compensated, T wb,crit , in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life was much lower than the 35 °C (95 °F) usually assumed, at about 30.55 °C (86.99 °F) in 36–40 °C (97–104 °F) humid environments, but progressively decreased in hotter, dry ambient environments. [ 39 ] [ 40 ] At low temperatures the body thermoregulates by generating heat, but this becomes unsustainable at extremely low temperatures. Historical understanding [ edit ] In the 19th century, most books quoted "blood heat" as 98 °F, until a study published the mean (but not the variance) of a large sample as 36.88 °C (98.38 °F). [ 41 ] Subsequently, that mean was widely quoted as "37 °C or 98.4 °F" [ 42 ] [ 43 ] until editors realized 37 °C is equal to 98.6 °F, not 98.4 °F. The 37 °C value was set by German physician Carl Reinhold August Wunderlich in his 1868 book, [ 44 ] which put temperature charts into widespread clinical use. [ 45 ] Dictionaries and other sources [ which? ] that quoted these averages did add the word "about" to show that there is some variance, but generally did not state how wide the variance is. [ citation needed ] ^ Marx J (2006). Rosen's emergency medicine : concepts and clinical practice (6th ed.). Philadelphia: Mosby/Elsevier. p. 2239. ISBN   978-0-323-02845-5 . OCLC   58533794 . ^ Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al. (June 2008). "Hypothermia therapy after traumatic brain injury in children". The New England Journal of Medicine . 358 (23): 2447– 56. doi : 10.1056/NEJMoa0706930 . PMID   18525042 . ^ Pryor JA, Prasad AS (2008). Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics . Elsevier Health Sciences. p. 8. ISBN   978-0702039744 . 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PMID   16549256 . ^ McKenzie, Jack E.; Osgood, David W. (2004). "Validation of a new telemetric core temperature monitor". Journal of Thermal Biology . 29 ( 7– 8): 605. Bibcode : 2004JTBio..29..605M . doi : 10.1016/j.jtherbio.2004.08.020 . ^ Nidermann, Reto; Wyss, Eva; Annaheim, Simon; Psikuta, Agnes; Davey, Sarah; Rossi, René Michel (January 2014). "Prediction of Human Core Body Temperature Using Non-Invasive Measurement Methods" . International Journal of Biometeorology . 58 (1): 7– 15. Bibcode : 2014IJBm...58....7N . doi : 10.1007/s00484-013-0687-2 . hdl : 20.500.11850/80468 . PMID   23760405 . S2CID   11772946 . ^ Mendt, Stefan; Maggioni, Martina Ana; Nordine, Michael; Steinach, Mathias; Opatz, Oliver; Belavy, Daniel; Felsenberg, Dieter; Koch, Joachim; Shang, Peng; Hanns-Christian, Gunga; Stahn, Alexander (2017). "Circadian Rhythms in Bed Rest: Monitoring Core Body Temperature via Heat-Flux Approach Is Superior to Skin Surface Temperature". Chronobiology International . 34 (5): 666– 676. doi : 10.1080/07420528.2016.1224241 . PMID   27726448 . S2CID   205581198 . ^ Uth, Marc-Florian; Koch, Jochim; Sattler, Frank (2016). "Body Core Temperature Sensing: Challenges and New Sensor Technologies" . Procedia Engineering . 168 : 89– 92. doi : 10.1016/j.proeng.2016.11.154 . ^ a b Bazett, H. C.; Love, L.; Newton, M.; Eisenberg, L.; Day, R.; Forster, R. (1948). "Temperature Changes in Blood Flowing in Arteries and Veins in Man". Journal of Applied Physiology . 1 (1): 3– 19. doi : 10.1152/jappl.1948.1.1.3 . ISSN   8750-7587 . PMID   18887571 . ^ Chudler, Eric H. "Biological Rhythms" , Neuroscience for Kids , faculty.washington.edu ^ temperature registered more than 115.7" , Bulletin Journal , August 7, 1980 ^ "2-latek z Polski rekordzistą. Przeżył wychłodzenie poniżej 12 st. C." Dziennik Naukowy (in Polish). 5 December 2014 . Retrieved 23 September 2022 . ^ Mroczek, T.; Gladki, M.; Skalski, J. (26 June 2020). "Successful resuscitation from accidental hypothermia of 11.8°C: where is the lower bound for human beings?" . European Journal of Cardio-Thoracic Surgery . 58 (5): 1091– 1092. doi : 10.1093/ejcts/ezaa159 . PMC   7886275 . PMID   33084865 . ^ Tomita, K., et al. "Examination of factors affecting the intraoral perception of object size: A preliminary study." Journal of oral rehabilitation 44.4 (2017): 237–243. ^ Al-Tubaikh, Jarrah Ali. "Infectious Diseases and Tropical Medicine." Internal Medicine. Springer, Cham, 2017. 441–493. ^ Vecellio, Daniel J.; Wolf, S. Tony; Cottle, Rachel M.; Kenney, W. Larry (2022-02-01). "Evaluating the 35°C wet-bulb temperature adaptability threshold for young, healthy subjects (PSU HEAT Project)" . Journal of Applied Physiology . 132 (2): 340– 345. doi : 10.1152/japplphysiol.00738.2021 . ISSN   8750-7587 . PMC   8799385 . PMID   34913738 . ^ Timperley, Jocelyn (31 July 2022). "Why you need to worry about the 'wet-bulb temperature' " . The Guardian . ^ Inwit Publishing, Inc. and Inwit, LLC – Writings, Links and Software Demonstrations – A Fahrenheit–Celsius Activity , inwit.com ^ Oxford Dictionary of English , 2010 edition, entry on "blood heat" ^ Collins English Dictionary , 1979 edition, entry on "blood heat" ^ Wunderlich, Carl Reinhold August (1868). Das Verhalten der Eigenwärme in Krankheiten [ The behavior of the self-warmth in diseases ]. Leipzig: O. Wigand. ; its 1871 2nd edition translated into English and published with the title On the temperature in diseases: a manual of medical thermometry . ^ Fischetti, Mark (2018), "Graphic Science: Goodbye, 98.6", Scientific American , vol. 319, no. 6 (December)
Markdown
[Jump to content](https://en.wikipedia.org/wiki/Human_body_temperature#bodyContent) Main menu Main menu move to sidebar hide Navigation - [Main page](https://en.wikipedia.org/wiki/Main_Page "Visit the main page [z]") - [Contents](https://en.wikipedia.org/wiki/Wikipedia:Contents "Guides to browsing Wikipedia") - [Current events](https://en.wikipedia.org/wiki/Portal:Current_events "Articles related to current events") - [Random article](https://en.wikipedia.org/wiki/Special:Random "Visit a randomly selected article [x]") - [About Wikipedia](https://en.wikipedia.org/wiki/Wikipedia:About "Learn about Wikipedia and how it works") - [Contact us](https://en.wikipedia.org/wiki/Wikipedia:Contact_us "How to contact Wikipedia") Contribute - [Help](https://en.wikipedia.org/wiki/Help:Contents "Guidance on how to use and edit Wikipedia") - [Learn to edit](https://en.wikipedia.org/wiki/Help:Introduction "Learn how to edit Wikipedia") - [Community portal](https://en.wikipedia.org/wiki/Wikipedia:Community_portal "The hub for editors") - [Recent changes](https://en.wikipedia.org/wiki/Special:RecentChanges "A list of recent changes to Wikipedia [r]") - [Upload file](https://en.wikipedia.org/wiki/Wikipedia:File_upload_wizard "Add images or other media for use on Wikipedia") - [Special pages](https://en.wikipedia.org/wiki/Special:SpecialPages "A list of all special pages [q]") [![](https://en.wikipedia.org/static/images/icons/enwiki-25.svg) ![Wikipedia](https://en.wikipedia.org/static/images/mobile/copyright/wikipedia-wordmark-en-25.svg) ![The Free Encyclopedia](https://en.wikipedia.org/static/images/mobile/copyright/wikipedia-tagline-en-25.svg)](https://en.wikipedia.org/wiki/Main_Page) [Search](https://en.wikipedia.org/wiki/Special:Search "Search Wikipedia [f]") Appearance - [Donate](https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=en.wikipedia.org&uselang=en) - [Create account](https://en.wikipedia.org/w/index.php?title=Special:CreateAccount&returnto=Human+body+temperature "You are encouraged to create an account and log in; however, it is not mandatory") - [Log in](https://en.wikipedia.org/w/index.php?title=Special:UserLogin&returnto=Human+body+temperature "You're encouraged to log in; however, it's not mandatory. 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[o]") ## Contents move to sidebar hide - [(Top)](https://en.wikipedia.org/wiki/Human_body_temperature) - [1 Methods of measurement](https://en.wikipedia.org/wiki/Human_body_temperature#Methods_of_measurement) Toggle Methods of measurement subsection - [1\.1 Variations](https://en.wikipedia.org/wiki/Human_body_temperature#Variations) - [1\.2 Natural rhythms](https://en.wikipedia.org/wiki/Human_body_temperature#Natural_rhythms) - [1\.3 Measurement methods](https://en.wikipedia.org/wiki/Human_body_temperature#Measurement_methods) - [1\.4 Infrared thermometer](https://en.wikipedia.org/wiki/Human_body_temperature#Infrared_thermometer) - [1\.5 Variations due to outside factors](https://en.wikipedia.org/wiki/Human_body_temperature#Variations_due_to_outside_factors) - [2 Concept](https://en.wikipedia.org/wiki/Human_body_temperature#Concept) Toggle Concept subsection - [2\.1 Fever](https://en.wikipedia.org/wiki/Human_body_temperature#Fever) - [2\.2 Hyperthermia](https://en.wikipedia.org/wiki/Human_body_temperature#Hyperthermia) - [2\.3 Hypothermia](https://en.wikipedia.org/wiki/Human_body_temperature#Hypothermia) - [2\.4 Basal body temperature](https://en.wikipedia.org/wiki/Human_body_temperature#Basal_body_temperature) - [2\.5 Core temperature](https://en.wikipedia.org/wiki/Human_body_temperature#Core_temperature) - [2\.6 Internal variation](https://en.wikipedia.org/wiki/Human_body_temperature#Internal_variation) - [3 Temperature variation](https://en.wikipedia.org/wiki/Human_body_temperature#Temperature_variation) Toggle Temperature variation subsection - [3\.1 Hot](https://en.wikipedia.org/wiki/Human_body_temperature#Hot) - [3\.2 Normal](https://en.wikipedia.org/wiki/Human_body_temperature#Normal) - [3\.3 Cold](https://en.wikipedia.org/wiki/Human_body_temperature#Cold) - [4 Effect of environment](https://en.wikipedia.org/wiki/Human_body_temperature#Effect_of_environment) - [5 Historical understanding](https://en.wikipedia.org/wiki/Human_body_temperature#Historical_understanding) - [6 References](https://en.wikipedia.org/wiki/Human_body_temperature#References) Toggle the table of contents # Human body temperature 16 languages - [العربية](https://ar.wikipedia.org/wiki/%D8%AD%D8%B1%D8%A7%D8%B1%D8%A9_%D8%A7%D9%84%D8%AC%D8%B3%D9%85_%D8%A7%D9%84%D8%A8%D8%B4%D8%B1%D9%8A "حرارة الجسم البشري – Arabic") - [تۆرکجه](https://azb.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%B3%D8%A7%D9%86%DB%8C%D9%86_%D9%86%D9%88%D8%B1%D9%85%D8%A7%D9%84_%D8%A8%D8%AF%D9%86_%D8%A7%DB%8C%D8%B3%D8%AA%DB%8C%E2%80%8C%D9%84%DB%8C%DA%AF%DB%8C "اینسانین نورمال بدن ایستی‌لیگی – South Azerbaijani") - [Català](https://ca.wikipedia.org/wiki/Temperatura_corporal_humana "Temperatura corporal humana – Catalan") - [کوردی](https://ckb.wikipedia.org/wiki/%D9%BE%D9%84%DB%95%DB%8C_%DA%AF%DB%95%D8%B1%D9%85%DB%8C%DB%8C_%D9%84%DB%95%D8%B4%DB%8C_%D9%85%D8%B1%DB%86%DA%A4 "پلەی گەرمیی لەشی مرۆڤ – Central Kurdish") - [Español](https://es.wikipedia.org/wiki/Temperatura_del_cuerpo_humano "Temperatura del cuerpo humano – Spanish") - [فارسی](https://fa.wikipedia.org/wiki/%D8%AF%D9%85%D8%A7%DB%8C_%D8%A8%D8%AF%D9%86_%D8%A7%D9%86%D8%B3%D8%A7%D9%86 "دمای بدن انسان – Persian") - [Français](https://fr.wikipedia.org/wiki/Temp%C3%A9rature_corporelle_humaine "Température corporelle humaine – French") - [עברית](https://he.wikipedia.org/wiki/%D7%98%D7%9E%D7%A4%D7%A8%D7%98%D7%95%D7%A8%D7%AA_%D7%92%D7%95%D7%A3_%D7%A0%D7%95%D7%A8%D7%9E%D7%9C%D7%99%D7%AA "טמפרטורת גוף נורמלית – Hebrew") - [Հայերեն](https://hy.wikipedia.org/wiki/%D5%84%D5%A1%D6%80%D5%A4%D5%B8%D6%82_%D5%B4%D5%A1%D6%80%D5%B4%D5%B6%D5%AB_%D5%BB%D5%A5%D6%80%D5%B4%D5%A1%D5%BD%D5%BF%D5%AB%D5%B3%D5%A1%D5%B6 "Մարդու մարմնի ջերմաստիճան – Armenian") - [Italiano](https://it.wikipedia.org/wiki/Temperatura_corporea_umana "Temperatura corporea umana – Italian") - [Bahasa Melayu](https://ms.wikipedia.org/wiki/Suhu_badan_manusia "Suhu badan manusia – Malay") - [Polski](https://pl.wikipedia.org/wiki/Temperatura_cia%C5%82a_cz%C5%82owieka "Temperatura ciała człowieka – Polish") - [ไทย](https://th.wikipedia.org/wiki/%E0%B8%AD%E0%B8%B8%E0%B8%93%E0%B8%AB%E0%B8%A0%E0%B8%B9%E0%B8%A1%E0%B8%B4%E0%B8%9B%E0%B8%81%E0%B8%95%E0%B8%B4%E0%B8%82%E0%B8%AD%E0%B8%87%E0%B8%A3%E0%B9%88%E0%B8%B2%E0%B8%87%E0%B8%81%E0%B8%B2%E0%B8%A2%E0%B8%A1%E0%B8%99%E0%B8%B8%E0%B8%A9%E0%B8%A2%E0%B9%8C "อุณหภูมิปกติของร่างกายมนุษย์ – Thai") - [Türkçe](https://tr.wikipedia.org/wiki/%C4%B0nsan_v%C3%BCcut_s%C4%B1cakl%C4%B1%C4%9F%C4%B1 "İnsan vücut sıcaklığı – Turkish") - [Tiếng Việt](https://vi.wikipedia.org/wiki/Nhi%E1%BB%87t_%C4%91%E1%BB%99_c%C6%A1_th%E1%BB%83_con_ng%C6%B0%E1%BB%9Di "Nhiệt độ cơ thể con người – Vietnamese") - [中文](https://zh.wikipedia.org/wiki/%E4%BA%BA%E9%AB%94%E6%BA%AB%E5%BA%A6 "人體溫度 – Chinese") [Edit links](https://www.wikidata.org/wiki/Special:EntityPage/Q16679262#sitelinks-wikipedia "Edit interlanguage links") - [Article](https://en.wikipedia.org/wiki/Human_body_temperature "View the content page [c]") - [Talk](https://en.wikipedia.org/wiki/Talk:Human_body_temperature "Discuss improvements to the content page [t]") English - [Read](https://en.wikipedia.org/wiki/Human_body_temperature) - [Edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit "Edit this page [e]") - [View history](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=history "Past revisions of this page [h]") Tools Tools move to sidebar hide Actions - 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[Get shortened URL](https://en.wikipedia.org/w/index.php?title=Special:UrlShortener&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FHuman_body_temperature) Print/export - [Download as PDF](https://en.wikipedia.org/w/index.php?title=Special:DownloadAsPdf&page=Human_body_temperature&action=show-download-screen "Download this page as a PDF file") - [Printable version](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&printable=yes "Printable version of this page [p]") In other projects - [Wikimedia Commons](https://commons.wikimedia.org/wiki/Category:Human_body_temperature) - [Wikidata item](https://www.wikidata.org/wiki/Special:EntityPage/Q16679262 "Structured data on this page hosted by Wikidata [g]") Appearance move to sidebar hide From Wikipedia, the free encyclopedia Typical temperature range found in humans | | | |---|---| | ![](https://upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/60px-Star_of_life.svg.png) | This article **needs more [reliable medical references](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)") for [verification](https://en.wikipedia.org/wiki/Wikipedia:Verifiability "Wikipedia:Verifiability") or relies too heavily on [primary sources](https://en.wikipedia.org/wiki/Wikipedia:Primary_sources "Wikipedia:Primary sources")**. Please review the contents of the article and [add the appropriate references](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit) if you can. Unsourced or poorly sourced material may be challenged and [removed](https://en.wikipedia.org/wiki/Wikipedia:Verifiability#Burden_of_evidence "Wikipedia:Verifiability"). *Find sources:* ["Human body temperature"](https://www.google.com/search?as_eq=wikipedia&q=%22Human+body+temperature%22) – [news](https://www.google.com/search?tbm=nws&q=%22Human+body+temperature%22+-wikipedia&tbs=ar:1) **·** [newspapers](https://www.google.com/search?&q=%22Human+body+temperature%22&tbs=bkt:s&tbm=bks) **·** [books](https://www.google.com/search?tbs=bks:1&q=%22Human+body+temperature%22+-wikipedia) **·** [scholar](https://scholar.google.com/scholar?q=%22Human+body+temperature%22) **·** [JSTOR](https://www.jstor.org/action/doBasicSearch?Query=%22Human+body+temperature%22&acc=on&wc=on) *(November 2022)* | | | | |---|---| | Temperature classification | | | | | | | [Core](https://en.wikipedia.org/wiki/Core_temperature#Core_temperature "Core temperature") (rectal, esophageal, etc.) | | [Hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia") | \<35.0 °C (95.0 °F)[\[1\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Rosen-1) | | [Normal]() | 36\.5–37.5 °C (97.7–99.5 °F)[\[2\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-pmid18788094-2)[\[3\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-3) | | [Fever](https://en.wikipedia.org/wiki/Fever "Fever") | \>37.5 or 38.3 °C (99.5 or 100.9 °F)[\[4\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-NC08-4)[\[5\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-CC09-5) | | [Hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia") | \>37.5 or 38.3 °C (99.5 or 100.9 °F)[\[4\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-NC08-4)[\[5\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-CC09-5) | | [Hyperpyrexia](https://en.wikipedia.org/wiki/Fever#Hyperpyrexia "Fever") | \>40.0 or 41.0 °C (104.0 or 105.8 °F)[\[6\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-6)[\[7\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-7) | | Note: The difference between fever and hyperthermia is the underlying mechanism. Different sources have different cut-offs for fever, hyperthermia and hyperpyrexia. | | | [v](https://en.wikipedia.org/wiki/Template:HumanTemperature "Template:HumanTemperature") [t](https://en.wikipedia.org/wiki/Template_talk:HumanTemperature "Template talk:HumanTemperature") [e](https://en.wikipedia.org/wiki/Special:EditPage/Template:HumanTemperature "Special:EditPage/Template:HumanTemperature") | | **Normal human body temperature** (**normothermia**, **euthermia**) is the typical [temperature](https://en.wikipedia.org/wiki/Temperature "Temperature") range found in [humans](https://en.wikipedia.org/wiki/Humans "Humans"). The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F).[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8)[\[9\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-pmid_37669046-9) Human body temperature varies. It depends on sex, age, time of day, exertion level, health status (such as illness and menstruation), what part of the [body](https://en.wikipedia.org/wiki/Human_body "Human body") the measurement is taken at, state of consciousness (waking, sleeping, sedated), and emotions. Body temperature is kept in the normal range by a [homeostatic](https://en.wikipedia.org/wiki/Homeostasis "Homeostasis") function known as [thermoregulation](https://en.wikipedia.org/wiki/Thermoregulation_in_humans "Thermoregulation in humans"), in which adjustment of temperature is triggered by the [central nervous system](https://en.wikipedia.org/wiki/Central_nervous_system "Central nervous system"). ## Methods of measurement \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=1 "Edit section: Methods of measurement")\] [![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/93/Clinical_thermometer_38.7.JPG/250px-Clinical_thermometer_38.7.JPG)](https://en.wikipedia.org/wiki/File:Clinical_thermometer_38.7.JPG) A [medical thermometer](https://en.wikipedia.org/wiki/Medical_thermometer "Medical thermometer") showing a temperature reading of 38.7 °C (101.7 °F) Taking a human's temperature is an initial part of a full [clinical examination](https://en.wikipedia.org/wiki/Clinical_examination "Clinical examination"). There are various types of [medical thermometers](https://en.wikipedia.org/wiki/Medical_thermometer "Medical thermometer"), as well as sites used for measurement, including: - Under the armpit (axillary temperature) - In the mouth (oral temperature) - In the [rectum](https://en.wikipedia.org/wiki/Rectum "Rectum") (rectal temperature) - In the ear (tympanic temperature) - On the skin of the forehead over the [temporal artery](https://en.wikipedia.org/wiki/Superficial_temporal_artery "Superficial temporal artery") - Using [heat flux sensors](https://en.wikipedia.org/wiki/Heat_flux_sensor "Heat flux sensor") ### Variations \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=2 "Edit section: Variations")\] [![](https://upload.wikimedia.org/wikipedia/commons/thumb/2/21/Body_Temp_Variation.svg/330px-Body_Temp_Variation.svg.png)](https://en.wikipedia.org/wiki/File:Body_Temp_Variation.svg) Diurnal variation in body temperature, ranging from about 37.5 °C (99.5 °F) from 10 a.m. to 6 p.m., and falling to about 36.4 °C (97.5 °F) from 2 a.m. to 6 a.m. (Based on figure in entry for 'Animal Heat' in 11th edition of the [Encyclopædia Britannica](https://en.wikipedia.org/wiki/Encyclop%C3%A6dia_Britannica "Encyclopædia Britannica"), 1910) [Temperature control](https://en.wikipedia.org/wiki/Thermoregulation_in_humans "Thermoregulation in humans") ([thermoregulation](https://en.wikipedia.org/wiki/Thermoregulation "Thermoregulation")) is a [homeostatic](https://en.wikipedia.org/wiki/Homeostatic "Homeostatic") mechanism that keeps the organism at optimum [operating temperature](https://en.wikipedia.org/wiki/Operating_temperature "Operating temperature"), as the temperature affects the rate of [chemical reactions](https://en.wikipedia.org/wiki/Chemical_reaction "Chemical reaction"). In [humans](https://en.wikipedia.org/wiki/Human "Human"), the average internal temperature is widely accepted to be 37 °C (98.6 °F), a "normal" temperature established in the 1800s. But newer studies show that average internal temperature for men and women is 36.4 °C (97.5 °F).[\[10\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-10) No person always has exactly the same temperature at every moment of the day. Temperatures cycle regularly up and down through the day, as controlled by the person's [circadian rhythm](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"). The lowest temperature occurs about two hours before the person normally wakes up. Additionally, temperatures change according to activities and external factors.[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11) In addition to varying throughout the day, normal body temperature may also differ as much as 0.5 °C (0.90 °F) from one day to the next, so that the highest or lowest temperatures on one day will not always exactly match the highest or lowest temperatures on the next day. Normal human body temperature varies slightly from person to person and by the time of day. Consequently, each type of measurement has a range of normal temperatures. The range for normal human body temperatures, taken orally, is 36.8 ± 0.5 °C (98.2 ± 0.9 °F).[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12) This means that any oral temperature between 36.3 and 37.3 °C (97.3 and 99.1 °F) is likely to be normal.[\[13\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-13) The normal human body temperature is often stated as 36.5–37.5 °C (97.7–99.5 °F).[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8)[\[9\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-pmid_37669046-9) In adults a review of the literature has found a wider range of 33.2–38.2 °C (91.8–100.8 °F) for normal temperatures, depending on the gender and location measured.[\[14\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SundLevander2002-14) Reported values vary depending on how it is measured: oral (under the tongue): 36.8 ± 0.4 °C (98.2 ± 0.7 °F),[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) internal ([rectal](https://en.wikipedia.org/wiki/Rectal "Rectal"), [vaginal](https://en.wikipedia.org/wiki/Vagina "Vagina")): 37.0 °C (98.6 °F).[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) A rectal or vaginal measurement taken directly inside the body cavity is typically slightly higher than oral measurement, and oral measurement is somewhat higher than skin measurement. Other places, such as under the arm or in the ear, produce different typical temperatures.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) While some people think of these averages as representing normal or ideal measurements, a wide range of temperatures has been found in healthy people.[\[5\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-CC09-5) The body temperature of a healthy person varies during the day by about 0.5 °C (0.9 °F) with lower temperatures in the morning and higher temperatures in the late afternoon and evening, as the body's needs and activities change.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Other circumstances also affect the body's temperature. The core body temperature of an individual tends to have the lowest value in the second half of the sleep cycle; the lowest point, called the [nadir](https://en.wikipedia.org/wiki/Nadir#Medicine "Nadir"), is one of the primary markers for [circadian rhythms](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"). The body temperature also changes when a person is hungry, sleepy, sick, or cold. ### Natural rhythms \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=3 "Edit section: Natural rhythms")\] Body temperature normally fluctuates over the day following [circadian rhythms](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"), with the lowest levels around 4 a.m. and the highest in the late afternoon, between 4:00 and 6:00 p.m. (assuming the person sleeps at night and stays awake during the day).[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12)[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Therefore, an oral temperature of 37.3 °C (99.1 °F) would, strictly speaking, be a normal, healthy temperature in the afternoon but not in the early morning.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) An individual's body temperature typically changes by about 0.5 °C (0.9 °F) between its highest and lowest points each day.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Body temperature is sensitive to many hormones, so women have a temperature rhythm that varies with the [menstrual cycle](https://en.wikipedia.org/wiki/Menstrual_cycle "Menstrual cycle"), called a *circamensal* rhythm.[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] A woman's [basal body temperature](https://en.wikipedia.org/wiki/Basal_body_temperature "Basal body temperature") rises sharply after [ovulation](https://en.wikipedia.org/wiki/Ovulation "Ovulation"), as [estrogen](https://en.wikipedia.org/wiki/Estrogen "Estrogen") production decreases and [progesterone](https://en.wikipedia.org/wiki/Progesterone "Progesterone") increases. [Fertility awareness](https://en.wikipedia.org/wiki/Fertility_awareness "Fertility awareness") programs use this change to identify when a woman has ovulated to achieve or avoid [pregnancy](https://en.wikipedia.org/wiki/Pregnancy "Pregnancy"). During the [luteal phase](https://en.wikipedia.org/wiki/Luteal_phase "Luteal phase") of the menstrual cycle, both the lowest and the average temperatures are slightly higher than during other parts of the cycle. However, the amount that the temperature rises during each day is slightly lower than typical, so the highest temperature of the day is not very much higher than usual.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] [Hormonal contraceptives](https://en.wikipedia.org/wiki/Hormonal_contraceptive "Hormonal contraceptive") both suppress the circamensal rhythm and raise the typical body temperature by about 0.6 °C (1.1 °F).[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Temperature also may vary with the change of [seasons](https://en.wikipedia.org/wiki/Season "Season") during each year. This pattern is called a *circannual* rhythm.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Studies of seasonal variations have produced inconsistent results. People living in different climates may have different seasonal patterns.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] It has been found that physically active individuals have larger changes in body temperature throughout the day. Physically active people have been reported to have lower body temperatures than their less active peers in the early morning and similar or higher body temperatures later in the day.[\[17\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Atkinson-17) With increased age, both average body temperature and the amount of daily variability in the body temperature tend to decrease.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Elderly people may have a decreased ability to generate body heat during a fever, so even a [somewhat elevated temperature](https://en.wikipedia.org/wiki/Low-grade_fever "Low-grade fever") can indicate a serious underlying cause in [geriatrics](https://en.wikipedia.org/wiki/Geriatrics "Geriatrics"). One study suggested that the average body temperature has also decreased since the 1850s.[\[18\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-18) The study's authors believe the most likely explanation for the change is a reduction in inflammation at the population level due to decreased chronic infections and improved hygiene.[\[19\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-19) ### Measurement methods \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=4 "Edit section: Measurement methods")\] | Method | Women | Men | |---|---|---| | Oral | 33\.2–38.1 °C (91.8–100.6 °F) | 35\.7–37.7 °C (96.3–99.9 °F) | | Rectal | 36\.8–37.1 °C (98.2–98.8 °F) | 36\.7–37.5 °C (98.1–99.5 °F) | | Tympanic | 35\.7–37.5 °C (96.3–99.5 °F) | 35\.5–37.5 °C (95.9–99.5 °F) | | Axillary | 35\.5–37.0 °C (95.9–98.6 °F) | | Different methods used for measuring temperature produce different results. The temperature reading depends on which part of the body is being measured. The typical daytime temperatures among healthy adults are as follows: - Temperature in the rectum (rectal), vagina, or in the ear (tympanic) is about 37.5 °C (99.5 °F)[\[20\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Elert2005-20)\[*[medical citation needed](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] - Temperature in the mouth (oral) is about 36.8 °C (98.2 °F)[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12) - Temperature under the arm (axillary) is about 36.5 °C (97.7 °F)[\[20\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Elert2005-20)\[*[medical citation needed](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Generally, oral, rectal, gut, and core body temperatures, although slightly different, are well-correlated.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] Oral temperatures are influenced by drinking, chewing, smoking, and breathing with the mouth open. [Mouth breathing](https://en.wikipedia.org/wiki/Mouth_breathing "Mouth breathing"), cold drinks or food reduce oral temperatures; hot drinks, hot food, chewing, and smoking raise oral temperatures.[\[21\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-21) Each measurement method also has different normal ranges depending on sex.[\[14\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SundLevander2002-14) ### Infrared thermometer \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=5 "Edit section: Infrared thermometer")\] Main article: [Infrared thermometer](https://en.wikipedia.org/wiki/Infrared_thermometer "Infrared thermometer") As of 2016, reviews of infrared thermometers have found them to be of variable accuracy.[\[22\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-22) This includes tympanic infrared thermometers in children.[\[23\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-23) ### Variations due to outside factors \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=6 "Edit section: Variations due to outside factors")\] Sleep disturbances also affect temperatures. Normally, body temperature drops significantly at a person's normal bedtime and throughout the night. Short-term [sleep deprivation](https://en.wikipedia.org/wiki/Sleep_deprivation "Sleep deprivation") produces a higher temperature at night than normal, but long-term sleep deprivation appears to reduce temperatures.[\[24\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-24) [Insomnia](https://en.wikipedia.org/wiki/Insomnia "Insomnia") and poor sleep quality are associated with smaller and later drops in body temperature.[\[25\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-25) Similarly, waking up unusually early, sleeping in, [jet lag](https://en.wikipedia.org/wiki/Jet_lag "Jet lag") and changes to [shift work](https://en.wikipedia.org/wiki/Shift_work "Shift work") schedules may affect body temperature. ## Concept \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=7 "Edit section: Concept")\] ### Fever \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=8 "Edit section: Fever")\] Main article: [Fever](https://en.wikipedia.org/wiki/Fever "Fever") A temperature *setpoint* is the level at which the body attempts to maintain its temperature. When the setpoint is raised, the result is a fever. Most fevers are caused by [infectious disease](https://en.wikipedia.org/wiki/Infectious_disease "Infectious disease") and can be lowered, if desired, with [antipyretic](https://en.wikipedia.org/wiki/Antipyretic "Antipyretic") medications. An early morning temperature higher than 37.3 °C (99.1 °F) or a late afternoon temperature higher than 37.7 °C (99.9 °F) is normally considered a fever, assuming that the temperature is elevated due to a change in the hypothalamus's setpoint.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Lower thresholds are sometimes appropriate for elderly people.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) The normal daily temperature variation is typically 0.5 °C (0.90 °F), but can be greater among people recovering from a fever.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) An organism at optimum temperature is considered *afebrile*, meaning "[without fever](https://en.wikipedia.org/wiki/Apyrexy "Apyrexy")".[\[26\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-26) If temperature is raised, but the setpoint is not raised, then the result is [hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia"). ### Hyperthermia \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=9 "Edit section: Hyperthermia")\] Main article: [Hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia") Hyperthermia occurs when the body produces or absorbs more heat than it can dissipate. It is usually caused by prolonged exposure to high temperatures. The heat-regulating mechanisms of the body eventually become overwhelmed and unable to deal effectively with the heat, causing the body temperature to climb uncontrollably. Hyperthermia at or above about 40 °C (104 °F) is a life-threatening medical emergency that requires immediate treatment. Common symptoms include headache, confusion, and fatigue. If sweating has resulted in dehydration, then the affected person may have dry, red skin. In a medical setting, mild hyperthermia is commonly called *heat exhaustion* or *heat prostration*; severe hyperthermia is called *heat stroke*. Heatstroke may come on suddenly, but it usually follows the untreated milder stages. Treatment involves cooling and rehydrating the body; fever-reducing drugs are useless for this condition. This may be done by moving out of direct sunlight to a cooler and shaded environment, drinking water, removing clothing that might keep heat close to the body, or sitting in front of a fan. Bathing in tepid or cool water, or even just [washing the face](https://en.wikipedia.org/wiki/Face_washing "Face washing") and other exposed areas of the skin, can be helpful. With fever, the body's core temperature rises to a higher temperature through the action of the part of the brain that controls the body temperature; with hyperthermia, the body temperature is raised without the influence of the heat control centers. ### Hypothermia \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=10 "Edit section: Hypothermia")\] Main article: [Hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia") In hypothermia, body temperature drops below that required for normal metabolism and bodily functions. In humans, this is usually due to excessive exposure to cold air or water, but it can be [deliberately induced as a medical treatment](https://en.wikipedia.org/wiki/Therapeutic_hypothermia "Therapeutic hypothermia"). Symptoms usually appear when the body's core temperature drops by 1–2 °C (1.8–3.6 °F) below normal temperature. ### Basal body temperature \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=11 "Edit section: Basal body temperature")\] Main article: [Basal body temperature](https://en.wikipedia.org/wiki/Basal_body_temperature "Basal body temperature") Basal body temperature is the lowest temperature attained by the body during rest (usually during sleep). It is generally measured immediately after awakening and before any physical activity has been undertaken, although the temperature measured at that time is somewhat higher than the true basal body temperature. In women, temperature differs at various points in the [menstrual cycle](https://en.wikipedia.org/wiki/Menstrual_cycle "Menstrual cycle"), and this can be used in the long term to track ovulation both to aid conception or avoid pregnancy. This process is called [fertility awareness](https://en.wikipedia.org/wiki/Fertility_awareness "Fertility awareness"). ### Core temperature \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=12 "Edit section: Core temperature")\] Core temperature, also called core body temperature, is the operating temperature of an [organism](https://en.wikipedia.org/wiki/Organism "Organism"), specifically in deep structures of the body such as the [liver](https://en.wikipedia.org/wiki/Liver "Liver"), in comparison to temperatures of peripheral tissues. Core temperature is normally maintained within a narrow range so that essential enzymatic reactions can occur. Significant core temperature elevation ([hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia")) or depression ([hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia")) over more than a brief period of time is fatal. Temperature examination in the [heart](https://en.wikipedia.org/wiki/Heart "Heart"), using a catheter, is the traditional [gold standard](https://en.wikipedia.org/wiki/Gold_standard_\(test\) "Gold standard (test)") measurement used to estimate core temperature (oral temperature is affected by hot or cold drinks, ambient temperature fluctuations as well as mouth-breathing). Since catheters are highly invasive, the generally accepted alternative for measuring core body temperature is through rectal measurements. Rectal temperature is expected to be approximately 1 °F (0.56 °C) higher than an oral temperature taken on the same person at the same time. Ear thermometers measure temperature from the [tympanic membrane](https://en.wikipedia.org/wiki/Tympanic_membrane "Tympanic membrane") using [infrared](https://en.wikipedia.org/wiki/Infrared "Infrared") sensors and also aim to measure core body temperature, since the blood supply of this membrane is directly shared with the [brain](https://en.wikipedia.org/wiki/Brain "Brain"). However, this method of measuring body temperature is not as accurate as rectal measurement and has a low sensitivity for fever, failing to determine three or four out of every ten fever measurements in children.[\[27\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Dodd-27) Ear temperature measurement may be acceptable for observing trends in body temperature but is less useful in consistently identifying and diagnosing fever. Until recently, direct measurement of core body temperature required either an ingestible device or surgical insertion of a probe. Therefore, a variety of indirect methods have commonly been used as the preferred alternative to these more accurate albeit more invasive methods. The [rectal](https://en.wikipedia.org/wiki/Rectum "Rectum") or [vaginal](https://en.wikipedia.org/wiki/Vagina "Vagina") temperature is generally considered to give the most accurate assessment of core body temperature, particularly in hypothermia. In the early 2000s, ingestible [thermistors](https://en.wikipedia.org/wiki/Thermistor "Thermistor") in [capsule](https://en.wikipedia.org/wiki/Capsule_\(pharmacy\) "Capsule (pharmacy)") form were produced, allowing the temperature inside the [digestive tract](https://en.wikipedia.org/wiki/Digestive_tract "Digestive tract") to be transmitted to an external receiver; one study found that these were comparable in accuracy to rectal temperature measurement.[\[28\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SciDirect-28) More recently, a new method using [heat flux sensors](https://en.wikipedia.org/wiki/Heat_flux_sensor "Heat flux sensor") have been developed. Several research papers show that its accuracy is similar to the invasive methods.[\[29\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-29)[\[30\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-30)[\[31\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-31) ### Internal variation \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=13 "Edit section: Internal variation")\] Measurement within the body finds internal variation temperatures as different as 21.5 °C (70.7 °F) for the [radial artery](https://en.wikipedia.org/wiki/Radial_artery "Radial artery") and 31.1 °C (88.0 °F) for the [brachial artery](https://en.wikipedia.org/wiki/Brachial_artery "Brachial artery").[\[32\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319-32) It has been observed that "chaos" has been "introduced into physiology by the fictitious assumption of a constant blood temperature".[\[32\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319-32) ## Temperature variation \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=14 "Edit section: Temperature variation")\] | | | |---|---| | [![icon](https://upload.wikimedia.org/wikipedia/en/thumb/9/99/Question_book-new.svg/60px-Question_book-new.svg.png)](https://en.wikipedia.org/wiki/File:Question_book-new.svg) | This section **needs additional citations for [verification](https://en.wikipedia.org/wiki/Wikipedia:Verifiability "Wikipedia:Verifiability")**. Please help [improve this article](https://en.wikipedia.org/wiki/Special:EditPage/Human_body_temperature "Special:EditPage/Human body temperature") by [adding citations to reliable sources](https://en.wikipedia.org/wiki/Help:Referencing_for_beginners "Help:Referencing for beginners") in this section. Unsourced material may be challenged and removed. *(July 2014)* *([Learn how and when to remove this message](https://en.wikipedia.org/wiki/Help:Maintenance_template_removal "Help:Maintenance template removal"))* | ### Hot \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=15 "Edit section: Hot")\] - 44 °C (111.2 °F) or more – Almost certainly death will occur; however, people have been known to survive up to 46.5 °C (115.7 °F).[\[33\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-33)[\[34\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-34) - 43 °C (109.4 °F) – Normally death, or there may be serious brain damage, convulsions, and shock. Cardio-respiratory collapse will likely occur. - 42 °C (107.6 °F) – Subject may turn red. They may become comatose, be in severe delirium, and convulsions can occur. - 41 °C (105.8 °F) – ([Medical emergency](https://en.wikipedia.org/wiki/Medical_emergency "Medical emergency")) – Fainting, severe headache, dizziness, confusion, hallucinations, delirium, and drowsiness can occur. There may also be [palpitations](https://en.wikipedia.org/wiki/Palpitations "Palpitations") and breathlessness. - 40 °C (104 °F) – Fainting, dehydration, weakness, headache, breathlessness, and dizziness may occur as well as profuse sweating. - 39 °C (102.2 °F) – Severe sweating, and red. Fast heart rate and breathlessness. There may be exhaustion accompanying this. Children and people with epilepsy may suffer convulsions at this temperature. - 38 °C (100.4 °F) – (Classed as [hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia") if not caused by a [fever](https://en.wikipedia.org/wiki/Fever "Fever")) – Feeling hot, sweating, feeling thirsty, feeling very uncomfortable. - 37\.6 °C (99.7 °F) — Classed as a slight fever. May lose appetite, feeling hot, feeling uncomfortable, feeling thirsty. ### Normal \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=16 "Edit section: Normal")\] - 36\.5–37.5 °C (97.7–99.5 °F) is a typically reported range for normal body temperature.[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8) ### Cold \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=17 "Edit section: Cold")\] - 35\.5 °C (95.9 °F) – Feeling cold, mild to moderate shivering. This can be a normal body temperature for sleeping. - 35 °C (95 °F) – Threshold for [hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia"). Intense shivering, numbness and bluish/grayness of the skin. There is the possibility of heart irritability. - 34 °C (93.2 °F) – Severe shivering, loss of movement of fingers, blueness, and confusion. Some behavioral changes may take place. - 33 °C (91.4 °F) – Moderate to severe confusion, sleepiness, depressed reflexes, progressive loss of shivering, slow heartbeat, shallow breathing. Shivering may stop. The subject may be unresponsive to certain stimuli. - 32 °C (89.6 °F) – ([Medical emergency](https://en.wikipedia.org/wiki/Medical_emergency "Medical emergency")) – Hallucinations, delirium, complete confusion, extreme sleepiness that is progressively becoming comatose. Shivering is absent. Reflex may be absent or very slight. - 31 °C (87.8 °F) – Comatose, very rarely conscious. No or slight reflexes. Very shallow breathing and slow heart rate. Possibility of serious heart rhythm problems. - 28 °C (82.4 °F) – Severe heart rhythm disturbances are likely and breathing may stop at any time. The person may appear to be dead.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] - 24–26 °C (75.2–78.8 °F) or less – Death usually occurs due to irregular heart beat or respiratory arrest; however, some patients have been known to survive with body temperatures lower than 12.7 °C (54.9 °F).[\[35\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-35) The lowest recorded core temperature from a patient with accidental hypothermia who survived without neurological [sequelae](https://en.wikipedia.org/wiki/Sequela "Sequela") is 11.8 °C (53.2 °F).[\[36\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-36) There are non-verbal corporal cues that can hint at an individual experiencing a low body temperature, which can be used for those with [dysphasia](https://en.wikipedia.org/wiki/Dysphasia "Dysphasia") or infants.[\[37\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-37) Examples of non-[verbal](https://en.wiktionary.org/wiki/verbal "wikt:verbal") cues of [coldness](https://en.wikipedia.org/wiki/Coldness "Coldness") include stillness and being lethargic, unusual paleness of skin among light-skinned people, and, among males, shrinkage, and contraction of the [scrotum](https://en.wikipedia.org/wiki/Scrotum "Scrotum").[\[38\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-38) ## Effect of environment \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=18 "Edit section: Effect of environment")\] Environmental conditions, primarily temperature and humidity, affect the ability of the mammalian body to thermoregulate. The [psychrometric temperature](https://en.wikipedia.org/wiki/Psychrometrics "Psychrometrics"), of which the [wet-bulb temperature](https://en.wikipedia.org/wiki/Wet-bulb_temperature "Wet-bulb temperature") is the main component, largely limits thermoregulation. It was thought that a wet-bulb temperature of about 35 °C (95 °F) was the highest sustained value consistent with human life. A 2022 study on the effect of heat on young people found that the critical wet-bulb temperature at which heat stress can no longer be compensated, Twb,crit, in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life was much lower than the 35 °C (95 °F) usually assumed, at about 30.55 °C (86.99 °F) in 36–40 °C (97–104 °F) humid environments, but progressively decreased in hotter, dry ambient environments.[\[39\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-vecellio-39)[\[40\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-timperley-40) At low temperatures the body thermoregulates by generating heat, but this becomes unsustainable at extremely low temperatures. ## Historical understanding \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=19 "Edit section: Historical understanding")\] In the 19th century, most books quoted "blood heat" as 98 °F, until a study published the mean (but not the variance) of a large sample as 36.88 °C (98.38 °F).[\[41\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-41) Subsequently, that mean was widely quoted as "37 °C or 98.4 °F"[\[42\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-42)[\[43\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-43) until editors realized 37 °C is equal to 98.6 °F, not 98.4 °F. The 37 °C value was set by German physician [Carl Reinhold August Wunderlich](https://en.wikipedia.org/wiki/Carl_Reinhold_August_Wunderlich "Carl Reinhold August Wunderlich") in his 1868 book,[\[44\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-44) which put temperature charts into widespread clinical use.[\[45\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-45) Dictionaries and other sources\[*[which?](https://en.wikipedia.org/wiki/Wikipedia:Avoid_weasel_words "Wikipedia:Avoid weasel words")*\] that quoted these averages did add the word "about" to show that there is some variance, but generally did not state how wide the variance is.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] ## References \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=20 "Edit section: References")\] 1. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Rosen_1-0)** Marx J (2006). *Rosen's emergency medicine : concepts and clinical practice* (6th ed.). Philadelphia: Mosby/Elsevier. p. 2239. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [978-0-323-02845-5](https://en.wikipedia.org/wiki/Special:BookSources/978-0-323-02845-5 "Special:BookSources/978-0-323-02845-5") . [OCLC](https://en.wikipedia.org/wiki/OCLC_\(identifier\) "OCLC (identifier)") [58533794](https://search.worldcat.org/oclc/58533794). 2. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-pmid18788094_2-0)** Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al. (June 2008). "Hypothermia therapy after traumatic brain injury in children". *The New England Journal of Medicine*. **358** (23): 2447–56\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1056/NEJMoa0706930](https://doi.org/10.1056%2FNEJMoa0706930). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [18525042](https://pubmed.ncbi.nlm.nih.gov/18525042). 3. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-3)** Pryor JA, Prasad AS (2008). [*Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics*](https://books.google.ca/books?id=5n9fseWPLowC&pg=PA8). Elsevier Health Sciences. p. 8. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [978-0702039744](https://en.wikipedia.org/wiki/Special:BookSources/978-0702039744 "Special:BookSources/978-0702039744") . "Body temperature is maintained within the range 36.5-37.5 °C. It is lowest in the early morning and highest in the afternoon." 4. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-NC08_4-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-NC08_4-1) Axelrod YK, Diringer MN (May 2008). 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[*Neurobiology of Hyperthermia*](https://books.google.com/books?id=Vk1UTlmEwrQC&pg=485#v=onepage&q=hyperpyrexia%20core%20temperature&f=false) (1st ed.). Elsevier. pp. 175–177, 485. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [9780080549996](https://en.wikipedia.org/wiki/Special:BookSources/9780080549996 "Special:BookSources/9780080549996") . Retrieved 19 November 2016. "Despite the myriad of complications associated with heat illness, an elevation of core temperature above 41.0 °C (often referred to as fever or hyperpyrexia) is the most widely recognized symptom of this syndrome." 8. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-1) [***c***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-2) Hutchison, James S.; et al. (June 2008). ["Hypothermia therapy after traumatic brain injury in children"](https://doi.org/10.1056%2FNEJMoa0706930). *New England Journal of Medicine*. **358** (23): 2447–2456\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1056/NEJMoa0706930](https://doi.org/10.1056%2FNEJMoa0706930). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [18525042](https://pubmed.ncbi.nlm.nih.gov/18525042). [S2CID](https://en.wikipedia.org/wiki/S2CID_\(identifier\) "S2CID (identifier)") [46833](https://api.semanticscholar.org/CorpusID:46833). "We hypothesized that, as compared with normothermia (36.5 to 37.5°C), treatment with hypothermia..." 9. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-pmid_37669046_9-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-pmid_37669046_9-1) Ley, C; Heath, F; Hastie, T; Gao, Z; Protsiv, M; Parsonnet, J (5 September 2023). 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[doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1080/07420528.2016.1224241](https://doi.org/10.1080%2F07420528.2016.1224241). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [27726448](https://pubmed.ncbi.nlm.nih.gov/27726448). [S2CID](https://en.wikipedia.org/wiki/S2CID_\(identifier\) "S2CID (identifier)") [205581198](https://api.semanticscholar.org/CorpusID:205581198). 31. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-31)** Uth, Marc-Florian; Koch, Jochim; Sattler, Frank (2016). ["Body Core Temperature Sensing: Challenges and New Sensor Technologies"](https://doi.org/10.1016%2Fj.proeng.2016.11.154). *Procedia Engineering*. **168**: 89–92\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1016/j.proeng.2016.11.154](https://doi.org/10.1016%2Fj.proeng.2016.11.154). 32. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319_32-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319_32-1) Bazett, H. C.; Love, L.; Newton, M.; Eisenberg, L.; Day, R.; Forster, R. (1948). "Temperature Changes in Blood Flowing in Arteries and Veins in Man". *Journal of Applied Physiology*. **1** (1): 3–19\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1152/jappl.1948.1.1.3](https://doi.org/10.1152%2Fjappl.1948.1.1.3). [ISSN](https://en.wikipedia.org/wiki/ISSN_\(identifier\) "ISSN (identifier)") [8750-7587](https://search.worldcat.org/issn/8750-7587). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [18887571](https://pubmed.ncbi.nlm.nih.gov/18887571). 33. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-33)** Chudler, Eric H. ["Biological Rhythms"](http://faculty.washington.edu/chudler/clock.html), *Neuroscience for Kids*, faculty.washington.edu 34. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-34)** [temperature registered more than 115.7"](https://news.google.com/newspapers?id=y4IwAAAAIBAJ&sjid=t0QDAAAAIBAJ&pg=4281,2822445&dq=115.7+degrees&hl=en), *Bulletin Journal*, August 7, 1980 35. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-35)** ["2-latek z Polski rekordzistą. Przeżył wychłodzenie poniżej 12 st. C."](https://dzienniknaukowy.pl/zdrowie/2-latek-z-polski-rekordzista-przezyl-wychlodzenie-ponizej-12-st-c) *Dziennik Naukowy* (in Polish). 5 December 2014. Retrieved 23 September 2022. 36. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-36)** Mroczek, T.; Gladki, M.; Skalski, J. (26 June 2020). ["Successful resuscitation from accidental hypothermia of 11.8°C: where is the lower bound for human beings?"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886275). *European Journal of Cardio-Thoracic Surgery*. **58** (5): 1091–1092\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1093/ejcts/ezaa159](https://doi.org/10.1093%2Fejcts%2Fezaa159). [PMC](https://en.wikipedia.org/wiki/PMC_\(identifier\) "PMC (identifier)") [7886275](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886275). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [33084865](https://pubmed.ncbi.nlm.nih.gov/33084865). 37. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-37)** Tomita, K., et al. "Examination of factors affecting the intraoral perception of object size: A preliminary study." Journal of oral rehabilitation 44.4 (2017): 237–243. 38. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-38)** Al-Tubaikh, Jarrah Ali. "Infectious Diseases and Tropical Medicine." Internal Medicine. Springer, Cham, 2017. 441–493. 39. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-vecellio_39-0)** Vecellio, Daniel J.; Wolf, S. Tony; Cottle, Rachel M.; Kenney, W. Larry (2022-02-01). ["Evaluating the 35°C wet-bulb temperature adaptability threshold for young, healthy subjects (PSU HEAT Project)"](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799385). *Journal of Applied Physiology*. **132** (2): 340–345\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1152/japplphysiol.00738.2021](https://doi.org/10.1152%2Fjapplphysiol.00738.2021). [ISSN](https://en.wikipedia.org/wiki/ISSN_\(identifier\) "ISSN (identifier)") [8750-7587](https://search.worldcat.org/issn/8750-7587). [PMC](https://en.wikipedia.org/wiki/PMC_\(identifier\) "PMC (identifier)") [8799385](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799385). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [34913738](https://pubmed.ncbi.nlm.nih.gov/34913738). 40. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-timperley_40-0)** Timperley, Jocelyn (31 July 2022). ["Why you need to worry about the 'wet-bulb temperature'"](https://www.theguardian.com/science/2022/jul/31/why-you-need-to-worry-about-the-wet-bulb-temperature). *The Guardian*. 41. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-41)** [Inwit Publishing, Inc. and Inwit, LLC – Writings, Links and Software Demonstrations – A Fahrenheit–Celsius Activity](https://web.archive.org/web/20110713052807/http://www.inwit.com/inwit/writings/fahrenheitcelsiusactivity.html), inwit.com 42. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-42)** *[Oxford Dictionary of English](https://en.wikipedia.org/wiki/Oxford_Dictionary_of_English "Oxford Dictionary of English")*, 2010 edition, entry on "blood heat" 43. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-43)** *[Collins English Dictionary](https://en.wikipedia.org/wiki/Collins_English_Dictionary "Collins English Dictionary")*, 1979 edition, entry on ["blood heat"](https://www.collinsdictionary.com/us/dictionary/english/blood-heat) 44. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-44)** Wunderlich, Carl Reinhold August (1868). [*Das Verhalten der Eigenwärme in Krankheiten*](https://archive.org/details/dasverhaltender00wundgoog) \[*The behavior of the self-warmth in diseases*\]. Leipzig: O. Wigand. ; its 1871 2nd edition translated into English and published with the title [*On the temperature in diseases: a manual of medical thermometry*](https://archive.org/details/ontemperaturein01wundgoog). 45. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-45)** Fischetti, Mark (2018), "Graphic Science: Goodbye, 98.6", *Scientific American*, vol. 319, no. 6 (December) ![](https://en.wikipedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=1) Retrieved from "<https://en.wikipedia.org/w/index.php?title=Human_body_temperature&oldid=1344460278>" [Categories](https://en.wikipedia.org/wiki/Help:Category "Help:Category"): - [Human physiology](https://en.wikipedia.org/wiki/Category:Human_physiology "Category:Human physiology") - [Medical terminology](https://en.wikipedia.org/wiki/Category:Medical_terminology "Category:Medical terminology") - [Temperature](https://en.wikipedia.org/wiki/Category:Temperature "Category:Temperature") - [Physical examination](https://en.wikipedia.org/wiki/Category:Physical_examination "Category:Physical examination") - [Medical signs](https://en.wikipedia.org/wiki/Category:Medical_signs "Category:Medical signs") - [Thermoregulation](https://en.wikipedia.org/wiki/Category:Thermoregulation "Category:Thermoregulation") - [Thermometers](https://en.wikipedia.org/wiki/Category:Thermometers "Category:Thermometers") Hidden categories: - [All articles lacking reliable references](https://en.wikipedia.org/wiki/Category:All_articles_lacking_reliable_references "Category:All articles lacking reliable references") - [Articles lacking reliable references from November 2017](https://en.wikipedia.org/wiki/Category:Articles_lacking_reliable_references_from_November_2017 "Category:Articles lacking reliable references from November 2017") - [CS1 maint: work parameter with ISBN](https://en.wikipedia.org/wiki/Category:CS1_maint:_work_parameter_with_ISBN "Category:CS1 maint: work parameter with ISBN") - [CS1 Polish-language sources (pl)](https://en.wikipedia.org/wiki/Category:CS1_Polish-language_sources_\(pl\) "Category:CS1 Polish-language sources (pl)") - [Articles with short description](https://en.wikipedia.org/wiki/Category:Articles_with_short_description "Category:Articles with short description") - [Short description matches Wikidata](https://en.wikipedia.org/wiki/Category:Short_description_matches_Wikidata "Category:Short description matches Wikidata") - [Articles needing additional medical references from November 2022](https://en.wikipedia.org/wiki/Category:Articles_needing_additional_medical_references_from_November_2022 "Category:Articles needing additional medical references from November 2022") - [All articles needing additional references](https://en.wikipedia.org/wiki/Category:All_articles_needing_additional_references "Category:All articles needing additional references") - [Articles requiring reliable medical sources](https://en.wikipedia.org/wiki/Category:Articles_requiring_reliable_medical_sources "Category:Articles requiring reliable medical sources") - [All articles with unsourced statements](https://en.wikipedia.org/wiki/Category:All_articles_with_unsourced_statements "Category:All articles with unsourced statements") - [Articles with unsourced statements from April 2021](https://en.wikipedia.org/wiki/Category:Articles_with_unsourced_statements_from_April_2021 "Category:Articles with unsourced statements from April 2021") - [Articles with unsourced statements from November 2017](https://en.wikipedia.org/wiki/Category:Articles_with_unsourced_statements_from_November_2017 "Category:Articles with unsourced statements from November 2017") - [Articles needing additional references from July 2014](https://en.wikipedia.org/wiki/Category:Articles_needing_additional_references_from_July_2014 "Category:Articles needing additional references from July 2014") - [All articles with specifically marked weasel-worded phrases](https://en.wikipedia.org/wiki/Category:All_articles_with_specifically_marked_weasel-worded_phrases "Category:All articles with specifically marked weasel-worded phrases") - [Articles with specifically marked weasel-worded phrases from October 2020](https://en.wikipedia.org/wiki/Category:Articles_with_specifically_marked_weasel-worded_phrases_from_October_2020 "Category:Articles with specifically marked weasel-worded phrases from October 2020") - [Articles with unsourced statements from June 2021](https://en.wikipedia.org/wiki/Category:Articles_with_unsourced_statements_from_June_2021 "Category:Articles with unsourced statements from June 2021") - This page was last edited on 20 March 2026, at 16:06 (UTC). - Text is available under the [Creative Commons Attribution-ShareAlike 4.0 License](https://en.wikipedia.org/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License "Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License"); additional terms may apply. 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**Normal human body temperature** (**normothermia**, **euthermia**) is the typical [temperature](https://en.wikipedia.org/wiki/Temperature "Temperature") range found in [humans](https://en.wikipedia.org/wiki/Humans "Humans"). The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F).[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8)[\[9\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-pmid_37669046-9) Human body temperature varies. It depends on sex, age, time of day, exertion level, health status (such as illness and menstruation), what part of the [body](https://en.wikipedia.org/wiki/Human_body "Human body") the measurement is taken at, state of consciousness (waking, sleeping, sedated), and emotions. Body temperature is kept in the normal range by a [homeostatic](https://en.wikipedia.org/wiki/Homeostasis "Homeostasis") function known as [thermoregulation](https://en.wikipedia.org/wiki/Thermoregulation_in_humans "Thermoregulation in humans"), in which adjustment of temperature is triggered by the [central nervous system](https://en.wikipedia.org/wiki/Central_nervous_system "Central nervous system"). ## Methods of measurement \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=1 "Edit section: Methods of measurement")\] [![](https://upload.wikimedia.org/wikipedia/commons/thumb/9/93/Clinical_thermometer_38.7.JPG/250px-Clinical_thermometer_38.7.JPG)](https://en.wikipedia.org/wiki/File:Clinical_thermometer_38.7.JPG) A [medical thermometer](https://en.wikipedia.org/wiki/Medical_thermometer "Medical thermometer") showing a temperature reading of 38.7 °C (101.7 °F) Taking a human's temperature is an initial part of a full [clinical examination](https://en.wikipedia.org/wiki/Clinical_examination "Clinical examination"). There are various types of [medical thermometers](https://en.wikipedia.org/wiki/Medical_thermometer "Medical thermometer"), as well as sites used for measurement, including: - Under the armpit (axillary temperature) - In the mouth (oral temperature) - In the [rectum](https://en.wikipedia.org/wiki/Rectum "Rectum") (rectal temperature) - In the ear (tympanic temperature) - On the skin of the forehead over the [temporal artery](https://en.wikipedia.org/wiki/Superficial_temporal_artery "Superficial temporal artery") - Using [heat flux sensors](https://en.wikipedia.org/wiki/Heat_flux_sensor "Heat flux sensor") [![](https://upload.wikimedia.org/wikipedia/commons/thumb/2/21/Body_Temp_Variation.svg/330px-Body_Temp_Variation.svg.png)](https://en.wikipedia.org/wiki/File:Body_Temp_Variation.svg) Diurnal variation in body temperature, ranging from about 37.5 °C (99.5 °F) from 10 a.m. to 6 p.m., and falling to about 36.4 °C (97.5 °F) from 2 a.m. to 6 a.m. (Based on figure in entry for 'Animal Heat' in 11th edition of the [Encyclopædia Britannica](https://en.wikipedia.org/wiki/Encyclop%C3%A6dia_Britannica "Encyclopædia Britannica"), 1910) [Temperature control](https://en.wikipedia.org/wiki/Thermoregulation_in_humans "Thermoregulation in humans") ([thermoregulation](https://en.wikipedia.org/wiki/Thermoregulation "Thermoregulation")) is a [homeostatic](https://en.wikipedia.org/wiki/Homeostatic "Homeostatic") mechanism that keeps the organism at optimum [operating temperature](https://en.wikipedia.org/wiki/Operating_temperature "Operating temperature"), as the temperature affects the rate of [chemical reactions](https://en.wikipedia.org/wiki/Chemical_reaction "Chemical reaction"). In [humans](https://en.wikipedia.org/wiki/Human "Human"), the average internal temperature is widely accepted to be 37 °C (98.6 °F), a "normal" temperature established in the 1800s. But newer studies show that average internal temperature for men and women is 36.4 °C (97.5 °F).[\[10\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-10) No person always has exactly the same temperature at every moment of the day. Temperatures cycle regularly up and down through the day, as controlled by the person's [circadian rhythm](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"). The lowest temperature occurs about two hours before the person normally wakes up. Additionally, temperatures change according to activities and external factors.[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11) In addition to varying throughout the day, normal body temperature may also differ as much as 0.5 °C (0.90 °F) from one day to the next, so that the highest or lowest temperatures on one day will not always exactly match the highest or lowest temperatures on the next day. Normal human body temperature varies slightly from person to person and by the time of day. Consequently, each type of measurement has a range of normal temperatures. The range for normal human body temperatures, taken orally, is 36.8 ± 0.5 °C (98.2 ± 0.9 °F).[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12) This means that any oral temperature between 36.3 and 37.3 °C (97.3 and 99.1 °F) is likely to be normal.[\[13\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-13) The normal human body temperature is often stated as 36.5–37.5 °C (97.7–99.5 °F).[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8)[\[9\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-pmid_37669046-9) In adults a review of the literature has found a wider range of 33.2–38.2 °C (91.8–100.8 °F) for normal temperatures, depending on the gender and location measured.[\[14\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SundLevander2002-14) Reported values vary depending on how it is measured: oral (under the tongue): 36.8 ± 0.4 °C (98.2 ± 0.7 °F),[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) internal ([rectal](https://en.wikipedia.org/wiki/Rectal "Rectal"), [vaginal](https://en.wikipedia.org/wiki/Vagina "Vagina")): 37.0 °C (98.6 °F).[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) A rectal or vaginal measurement taken directly inside the body cavity is typically slightly higher than oral measurement, and oral measurement is somewhat higher than skin measurement. Other places, such as under the arm or in the ear, produce different typical temperatures.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) While some people think of these averages as representing normal or ideal measurements, a wide range of temperatures has been found in healthy people.[\[5\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-CC09-5) The body temperature of a healthy person varies during the day by about 0.5 °C (0.9 °F) with lower temperatures in the morning and higher temperatures in the late afternoon and evening, as the body's needs and activities change.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Other circumstances also affect the body's temperature. The core body temperature of an individual tends to have the lowest value in the second half of the sleep cycle; the lowest point, called the [nadir](https://en.wikipedia.org/wiki/Nadir#Medicine "Nadir"), is one of the primary markers for [circadian rhythms](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"). The body temperature also changes when a person is hungry, sleepy, sick, or cold. Body temperature normally fluctuates over the day following [circadian rhythms](https://en.wikipedia.org/wiki/Circadian_rhythm "Circadian rhythm"), with the lowest levels around 4 a.m. and the highest in the late afternoon, between 4:00 and 6:00 p.m. (assuming the person sleeps at night and stays awake during the day).[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12)[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Therefore, an oral temperature of 37.3 °C (99.1 °F) would, strictly speaking, be a normal, healthy temperature in the afternoon but not in the early morning.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) An individual's body temperature typically changes by about 0.5 °C (0.9 °F) between its highest and lowest points each day.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Body temperature is sensitive to many hormones, so women have a temperature rhythm that varies with the [menstrual cycle](https://en.wikipedia.org/wiki/Menstrual_cycle "Menstrual cycle"), called a *circamensal* rhythm.[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] A woman's [basal body temperature](https://en.wikipedia.org/wiki/Basal_body_temperature "Basal body temperature") rises sharply after [ovulation](https://en.wikipedia.org/wiki/Ovulation "Ovulation"), as [estrogen](https://en.wikipedia.org/wiki/Estrogen "Estrogen") production decreases and [progesterone](https://en.wikipedia.org/wiki/Progesterone "Progesterone") increases. [Fertility awareness](https://en.wikipedia.org/wiki/Fertility_awareness "Fertility awareness") programs use this change to identify when a woman has ovulated to achieve or avoid [pregnancy](https://en.wikipedia.org/wiki/Pregnancy "Pregnancy"). During the [luteal phase](https://en.wikipedia.org/wiki/Luteal_phase "Luteal phase") of the menstrual cycle, both the lowest and the average temperatures are slightly higher than during other parts of the cycle. However, the amount that the temperature rises during each day is slightly lower than typical, so the highest temperature of the day is not very much higher than usual.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] [Hormonal contraceptives](https://en.wikipedia.org/wiki/Hormonal_contraceptive "Hormonal contraceptive") both suppress the circamensal rhythm and raise the typical body temperature by about 0.6 °C (1.1 °F).[\[11\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly-11)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Temperature also may vary with the change of [seasons](https://en.wikipedia.org/wiki/Season "Season") during each year. This pattern is called a *circannual* rhythm.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Studies of seasonal variations have produced inconsistent results. People living in different climates may have different seasonal patterns.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] It has been found that physically active individuals have larger changes in body temperature throughout the day. Physically active people have been reported to have lower body temperatures than their less active peers in the early morning and similar or higher body temperatures later in the day.[\[17\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Atkinson-17) With increased age, both average body temperature and the amount of daily variability in the body temperature tend to decrease.[\[16\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kelly1-16)\[*[unreliable medical source?](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Elderly people may have a decreased ability to generate body heat during a fever, so even a [somewhat elevated temperature](https://en.wikipedia.org/wiki/Low-grade_fever "Low-grade fever") can indicate a serious underlying cause in [geriatrics](https://en.wikipedia.org/wiki/Geriatrics "Geriatrics"). One study suggested that the average body temperature has also decreased since the 1850s.[\[18\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-18) The study's authors believe the most likely explanation for the change is a reduction in inflammation at the population level due to decreased chronic infections and improved hygiene.[\[19\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-19) ### Measurement methods \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=4 "Edit section: Measurement methods")\] | Method | Women | Men | |---|---|---| | Oral | 33\.2–38.1 °C (91.8–100.6 °F) | 35\.7–37.7 °C (96.3–99.9 °F) | | Rectal | 36\.8–37.1 °C (98.2–98.8 °F) | 36\.7–37.5 °C (98.1–99.5 °F) | | Tympanic | 35\.7–37.5 °C (96.3–99.5 °F) | 35\.5–37.5 °C (95.9–99.5 °F) | | Axillary | 35\.5–37.0 °C (95.9–98.6 °F) | | Different methods used for measuring temperature produce different results. The temperature reading depends on which part of the body is being measured. The typical daytime temperatures among healthy adults are as follows: - Temperature in the rectum (rectal), vagina, or in the ear (tympanic) is about 37.5 °C (99.5 °F)[\[20\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Elert2005-20)\[*[medical citation needed](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] - Temperature in the mouth (oral) is about 36.8 °C (98.2 °F)[\[12\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Mac-12) - Temperature under the arm (axillary) is about 36.5 °C (97.7 °F)[\[20\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Elert2005-20)\[*[medical citation needed](https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_\(medicine\) "Wikipedia:Identifying reliable sources (medicine)")*\] Generally, oral, rectal, gut, and core body temperatures, although slightly different, are well-correlated.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] Oral temperatures are influenced by drinking, chewing, smoking, and breathing with the mouth open. [Mouth breathing](https://en.wikipedia.org/wiki/Mouth_breathing "Mouth breathing"), cold drinks or food reduce oral temperatures; hot drinks, hot food, chewing, and smoking raise oral temperatures.[\[21\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-21) Each measurement method also has different normal ranges depending on sex.[\[14\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SundLevander2002-14) ### Infrared thermometer \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=5 "Edit section: Infrared thermometer")\] As of 2016, reviews of infrared thermometers have found them to be of variable accuracy.[\[22\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-22) This includes tympanic infrared thermometers in children.[\[23\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-23) ### Variations due to outside factors \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=6 "Edit section: Variations due to outside factors")\] Sleep disturbances also affect temperatures. Normally, body temperature drops significantly at a person's normal bedtime and throughout the night. Short-term [sleep deprivation](https://en.wikipedia.org/wiki/Sleep_deprivation "Sleep deprivation") produces a higher temperature at night than normal, but long-term sleep deprivation appears to reduce temperatures.[\[24\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-24) [Insomnia](https://en.wikipedia.org/wiki/Insomnia "Insomnia") and poor sleep quality are associated with smaller and later drops in body temperature.[\[25\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-25) Similarly, waking up unusually early, sleeping in, [jet lag](https://en.wikipedia.org/wiki/Jet_lag "Jet lag") and changes to [shift work](https://en.wikipedia.org/wiki/Shift_work "Shift work") schedules may affect body temperature. A temperature *setpoint* is the level at which the body attempts to maintain its temperature. When the setpoint is raised, the result is a fever. Most fevers are caused by [infectious disease](https://en.wikipedia.org/wiki/Infectious_disease "Infectious disease") and can be lowered, if desired, with [antipyretic](https://en.wikipedia.org/wiki/Antipyretic "Antipyretic") medications. An early morning temperature higher than 37.3 °C (99.1 °F) or a late afternoon temperature higher than 37.7 °C (99.9 °F) is normally considered a fever, assuming that the temperature is elevated due to a change in the hypothalamus's setpoint.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) Lower thresholds are sometimes appropriate for elderly people.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) The normal daily temperature variation is typically 0.5 °C (0.90 °F), but can be greater among people recovering from a fever.[\[15\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Longo-15) An organism at optimum temperature is considered *afebrile*, meaning "[without fever](https://en.wikipedia.org/wiki/Apyrexy "Apyrexy")".[\[26\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-26) If temperature is raised, but the setpoint is not raised, then the result is [hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia"). Hyperthermia occurs when the body produces or absorbs more heat than it can dissipate. It is usually caused by prolonged exposure to high temperatures. The heat-regulating mechanisms of the body eventually become overwhelmed and unable to deal effectively with the heat, causing the body temperature to climb uncontrollably. Hyperthermia at or above about 40 °C (104 °F) is a life-threatening medical emergency that requires immediate treatment. Common symptoms include headache, confusion, and fatigue. If sweating has resulted in dehydration, then the affected person may have dry, red skin. In a medical setting, mild hyperthermia is commonly called *heat exhaustion* or *heat prostration*; severe hyperthermia is called *heat stroke*. Heatstroke may come on suddenly, but it usually follows the untreated milder stages. Treatment involves cooling and rehydrating the body; fever-reducing drugs are useless for this condition. This may be done by moving out of direct sunlight to a cooler and shaded environment, drinking water, removing clothing that might keep heat close to the body, or sitting in front of a fan. Bathing in tepid or cool water, or even just [washing the face](https://en.wikipedia.org/wiki/Face_washing "Face washing") and other exposed areas of the skin, can be helpful. With fever, the body's core temperature rises to a higher temperature through the action of the part of the brain that controls the body temperature; with hyperthermia, the body temperature is raised without the influence of the heat control centers. In hypothermia, body temperature drops below that required for normal metabolism and bodily functions. In humans, this is usually due to excessive exposure to cold air or water, but it can be [deliberately induced as a medical treatment](https://en.wikipedia.org/wiki/Therapeutic_hypothermia "Therapeutic hypothermia"). Symptoms usually appear when the body's core temperature drops by 1–2 °C (1.8–3.6 °F) below normal temperature. ### Basal body temperature \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=11 "Edit section: Basal body temperature")\] Basal body temperature is the lowest temperature attained by the body during rest (usually during sleep). It is generally measured immediately after awakening and before any physical activity has been undertaken, although the temperature measured at that time is somewhat higher than the true basal body temperature. In women, temperature differs at various points in the [menstrual cycle](https://en.wikipedia.org/wiki/Menstrual_cycle "Menstrual cycle"), and this can be used in the long term to track ovulation both to aid conception or avoid pregnancy. This process is called [fertility awareness](https://en.wikipedia.org/wiki/Fertility_awareness "Fertility awareness"). Core temperature, also called core body temperature, is the operating temperature of an [organism](https://en.wikipedia.org/wiki/Organism "Organism"), specifically in deep structures of the body such as the [liver](https://en.wikipedia.org/wiki/Liver "Liver"), in comparison to temperatures of peripheral tissues. Core temperature is normally maintained within a narrow range so that essential enzymatic reactions can occur. Significant core temperature elevation ([hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia")) or depression ([hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia")) over more than a brief period of time is fatal. Temperature examination in the [heart](https://en.wikipedia.org/wiki/Heart "Heart"), using a catheter, is the traditional [gold standard](https://en.wikipedia.org/wiki/Gold_standard_\(test\) "Gold standard (test)") measurement used to estimate core temperature (oral temperature is affected by hot or cold drinks, ambient temperature fluctuations as well as mouth-breathing). Since catheters are highly invasive, the generally accepted alternative for measuring core body temperature is through rectal measurements. Rectal temperature is expected to be approximately 1 °F (0.56 °C) higher than an oral temperature taken on the same person at the same time. Ear thermometers measure temperature from the [tympanic membrane](https://en.wikipedia.org/wiki/Tympanic_membrane "Tympanic membrane") using [infrared](https://en.wikipedia.org/wiki/Infrared "Infrared") sensors and also aim to measure core body temperature, since the blood supply of this membrane is directly shared with the [brain](https://en.wikipedia.org/wiki/Brain "Brain"). However, this method of measuring body temperature is not as accurate as rectal measurement and has a low sensitivity for fever, failing to determine three or four out of every ten fever measurements in children.[\[27\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Dodd-27) Ear temperature measurement may be acceptable for observing trends in body temperature but is less useful in consistently identifying and diagnosing fever. Until recently, direct measurement of core body temperature required either an ingestible device or surgical insertion of a probe. Therefore, a variety of indirect methods have commonly been used as the preferred alternative to these more accurate albeit more invasive methods. The [rectal](https://en.wikipedia.org/wiki/Rectum "Rectum") or [vaginal](https://en.wikipedia.org/wiki/Vagina "Vagina") temperature is generally considered to give the most accurate assessment of core body temperature, particularly in hypothermia. In the early 2000s, ingestible [thermistors](https://en.wikipedia.org/wiki/Thermistor "Thermistor") in [capsule](https://en.wikipedia.org/wiki/Capsule_\(pharmacy\) "Capsule (pharmacy)") form were produced, allowing the temperature inside the [digestive tract](https://en.wikipedia.org/wiki/Digestive_tract "Digestive tract") to be transmitted to an external receiver; one study found that these were comparable in accuracy to rectal temperature measurement.[\[28\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-SciDirect-28) More recently, a new method using [heat flux sensors](https://en.wikipedia.org/wiki/Heat_flux_sensor "Heat flux sensor") have been developed. Several research papers show that its accuracy is similar to the invasive methods.[\[29\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-29)[\[30\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-30)[\[31\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-31) Measurement within the body finds internal variation temperatures as different as 21.5 °C (70.7 °F) for the [radial artery](https://en.wikipedia.org/wiki/Radial_artery "Radial artery") and 31.1 °C (88.0 °F) for the [brachial artery](https://en.wikipedia.org/wiki/Brachial_artery "Brachial artery").[\[32\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319-32) It has been observed that "chaos" has been "introduced into physiology by the fictitious assumption of a constant blood temperature".[\[32\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Bazett_Love_Newton_Eisenberg_1948_pp._3%E2%80%9319-32) ## Temperature variation \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=14 "Edit section: Temperature variation")\] - 44 °C (111.2 °F) or more – Almost certainly death will occur; however, people have been known to survive up to 46.5 °C (115.7 °F).[\[33\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-33)[\[34\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-34) - 43 °C (109.4 °F) – Normally death, or there may be serious brain damage, convulsions, and shock. Cardio-respiratory collapse will likely occur. - 42 °C (107.6 °F) – Subject may turn red. They may become comatose, be in severe delirium, and convulsions can occur. - 41 °C (105.8 °F) – ([Medical emergency](https://en.wikipedia.org/wiki/Medical_emergency "Medical emergency")) – Fainting, severe headache, dizziness, confusion, hallucinations, delirium, and drowsiness can occur. There may also be [palpitations](https://en.wikipedia.org/wiki/Palpitations "Palpitations") and breathlessness. - 40 °C (104 °F) – Fainting, dehydration, weakness, headache, breathlessness, and dizziness may occur as well as profuse sweating. - 39 °C (102.2 °F) – Severe sweating, and red. Fast heart rate and breathlessness. There may be exhaustion accompanying this. Children and people with epilepsy may suffer convulsions at this temperature. - 38 °C (100.4 °F) – (Classed as [hyperthermia](https://en.wikipedia.org/wiki/Hyperthermia "Hyperthermia") if not caused by a [fever](https://en.wikipedia.org/wiki/Fever "Fever")) – Feeling hot, sweating, feeling thirsty, feeling very uncomfortable. - 37\.6 °C (99.7 °F) — Classed as a slight fever. May lose appetite, feeling hot, feeling uncomfortable, feeling thirsty. - 36\.5–37.5 °C (97.7–99.5 °F) is a typically reported range for normal body temperature.[\[8\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-Kar2008-8) - 35\.5 °C (95.9 °F) – Feeling cold, mild to moderate shivering. This can be a normal body temperature for sleeping. - 35 °C (95 °F) – Threshold for [hypothermia](https://en.wikipedia.org/wiki/Hypothermia "Hypothermia"). Intense shivering, numbness and bluish/grayness of the skin. There is the possibility of heart irritability. - 34 °C (93.2 °F) – Severe shivering, loss of movement of fingers, blueness, and confusion. Some behavioral changes may take place. - 33 °C (91.4 °F) – Moderate to severe confusion, sleepiness, depressed reflexes, progressive loss of shivering, slow heartbeat, shallow breathing. Shivering may stop. The subject may be unresponsive to certain stimuli. - 32 °C (89.6 °F) – ([Medical emergency](https://en.wikipedia.org/wiki/Medical_emergency "Medical emergency")) – Hallucinations, delirium, complete confusion, extreme sleepiness that is progressively becoming comatose. Shivering is absent. Reflex may be absent or very slight. - 31 °C (87.8 °F) – Comatose, very rarely conscious. No or slight reflexes. Very shallow breathing and slow heart rate. Possibility of serious heart rhythm problems. - 28 °C (82.4 °F) – Severe heart rhythm disturbances are likely and breathing may stop at any time. The person may appear to be dead.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] - 24–26 °C (75.2–78.8 °F) or less – Death usually occurs due to irregular heart beat or respiratory arrest; however, some patients have been known to survive with body temperatures lower than 12.7 °C (54.9 °F).[\[35\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-35) The lowest recorded core temperature from a patient with accidental hypothermia who survived without neurological [sequelae](https://en.wikipedia.org/wiki/Sequela "Sequela") is 11.8 °C (53.2 °F).[\[36\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-36) There are non-verbal corporal cues that can hint at an individual experiencing a low body temperature, which can be used for those with [dysphasia](https://en.wikipedia.org/wiki/Dysphasia "Dysphasia") or infants.[\[37\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-37) Examples of non-[verbal](https://en.wiktionary.org/wiki/verbal "wikt:verbal") cues of [coldness](https://en.wikipedia.org/wiki/Coldness "Coldness") include stillness and being lethargic, unusual paleness of skin among light-skinned people, and, among males, shrinkage, and contraction of the [scrotum](https://en.wikipedia.org/wiki/Scrotum "Scrotum").[\[38\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-38) ## Effect of environment \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=18 "Edit section: Effect of environment")\] Environmental conditions, primarily temperature and humidity, affect the ability of the mammalian body to thermoregulate. The [psychrometric temperature](https://en.wikipedia.org/wiki/Psychrometrics "Psychrometrics"), of which the [wet-bulb temperature](https://en.wikipedia.org/wiki/Wet-bulb_temperature "Wet-bulb temperature") is the main component, largely limits thermoregulation. It was thought that a wet-bulb temperature of about 35 °C (95 °F) was the highest sustained value consistent with human life. A 2022 study on the effect of heat on young people found that the critical wet-bulb temperature at which heat stress can no longer be compensated, Twb,crit, in young, healthy adults performing tasks at modest metabolic rates mimicking basic activities of daily life was much lower than the 35 °C (95 °F) usually assumed, at about 30.55 °C (86.99 °F) in 36–40 °C (97–104 °F) humid environments, but progressively decreased in hotter, dry ambient environments.[\[39\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-vecellio-39)[\[40\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-timperley-40) At low temperatures the body thermoregulates by generating heat, but this becomes unsustainable at extremely low temperatures. ## Historical understanding \[[edit](https://en.wikipedia.org/w/index.php?title=Human_body_temperature&action=edit&section=19 "Edit section: Historical understanding")\] In the 19th century, most books quoted "blood heat" as 98 °F, until a study published the mean (but not the variance) of a large sample as 36.88 °C (98.38 °F).[\[41\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-41) Subsequently, that mean was widely quoted as "37 °C or 98.4 °F"[\[42\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-42)[\[43\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-43) until editors realized 37 °C is equal to 98.6 °F, not 98.4 °F. The 37 °C value was set by German physician [Carl Reinhold August Wunderlich](https://en.wikipedia.org/wiki/Carl_Reinhold_August_Wunderlich "Carl Reinhold August Wunderlich") in his 1868 book,[\[44\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-44) which put temperature charts into widespread clinical use.[\[45\]](https://en.wikipedia.org/wiki/Human_body_temperature#cite_note-45) Dictionaries and other sources\[*[which?](https://en.wikipedia.org/wiki/Wikipedia:Avoid_weasel_words "Wikipedia:Avoid weasel words")*\] that quoted these averages did add the word "about" to show that there is some variance, but generally did not state how wide the variance is.\[*[citation needed](https://en.wikipedia.org/wiki/Wikipedia:Citation_needed "Wikipedia:Citation needed")*\] 1. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Rosen_1-0)** Marx J (2006). *Rosen's emergency medicine : concepts and clinical practice* (6th ed.). Philadelphia: Mosby/Elsevier. p. 2239. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [978-0-323-02845-5](https://en.wikipedia.org/wiki/Special:BookSources/978-0-323-02845-5 "Special:BookSources/978-0-323-02845-5") . [OCLC](https://en.wikipedia.org/wiki/OCLC_\(identifier\) "OCLC (identifier)") [58533794](https://search.worldcat.org/oclc/58533794). 2. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-pmid18788094_2-0)** Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, et al. (June 2008). "Hypothermia therapy after traumatic brain injury in children". *The New England Journal of Medicine*. **358** (23): 2447–56\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1056/NEJMoa0706930](https://doi.org/10.1056%2FNEJMoa0706930). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [18525042](https://pubmed.ncbi.nlm.nih.gov/18525042). 3. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-3)** Pryor JA, Prasad AS (2008). [*Physiotherapy for Respiratory and Cardiac Problems: Adults and Paediatrics*](https://books.google.ca/books?id=5n9fseWPLowC&pg=PA8). Elsevier Health Sciences. p. 8. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [978-0702039744](https://en.wikipedia.org/wiki/Special:BookSources/978-0702039744 "Special:BookSources/978-0702039744") . "Body temperature is maintained within the range 36.5-37.5 °C. It is lowest in the early morning and highest in the afternoon." 4. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-NC08_4-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-NC08_4-1) Axelrod YK, Diringer MN (May 2008). "Temperature management in acute neurologic disorders". *Neurologic Clinics*. **26** (2): 585–603, xi. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1016/j.ncl.2008.02.005](https://doi.org/10.1016%2Fj.ncl.2008.02.005). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [18514828](https://pubmed.ncbi.nlm.nih.gov/18514828). 5. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-CC09_5-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-CC09_5-1) [***c***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-CC09_5-2) Laupland KB (July 2009). "Fever in the critically ill medical patient". *Critical Care Medicine*. **37** (7 Suppl): S273-8. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1097/CCM.0b013e3181aa6117](https://doi.org/10.1097%2FCCM.0b013e3181aa6117). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [19535958](https://pubmed.ncbi.nlm.nih.gov/19535958). 6. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-6)** Grunau BE, Wiens MO, Brubacher JR (September 2010). "Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review". *Cjem*. **12** (5): 435–42\. [doi](https://en.wikipedia.org/wiki/Doi_\(identifier\) "Doi (identifier)"):[10\.1017/s1481803500012598](https://doi.org/10.1017%2Fs1481803500012598). [PMID](https://en.wikipedia.org/wiki/PMID_\(identifier\) "PMID (identifier)") [20880437](https://pubmed.ncbi.nlm.nih.gov/20880437). "Dantrolene may also be associated with improved survival and reduced complications, especially in patients with extreme (≥ 42 °C) or severe (≥ 40 °C) hyperpyrexia" 7. **[^](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-7)** Sharma HS, ed. (2007). [*Neurobiology of Hyperthermia*](https://books.google.com/books?id=Vk1UTlmEwrQC&pg=485#v=onepage&q=hyperpyrexia%20core%20temperature&f=false) (1st ed.). Elsevier. pp. 175–177, 485. [ISBN](https://en.wikipedia.org/wiki/ISBN_\(identifier\) "ISBN (identifier)") [9780080549996](https://en.wikipedia.org/wiki/Special:BookSources/9780080549996 "Special:BookSources/9780080549996") . Retrieved 19 November 2016. "Despite the myriad of complications associated with heat illness, an elevation of core temperature above 41.0 °C (often referred to as fever or hyperpyrexia) is the most widely recognized symptom of this syndrome." 8. ^ [***a***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-0) [***b***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-1) [***c***](https://en.wikipedia.org/wiki/Human_body_temperature#cite_ref-Kar2008_8-2) Hutchison, James S.; et al. (June 2008). 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