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URLhttps://cks.nice.org.uk/topics/depression/diagnosis/assessment/
Last Crawled2026-03-28 13:53:35 (11 days ago)
First Indexed2022-10-09 02:37:18 (3 years ago)
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Meta TitleAssessment | Diagnosis | Depression | CKS | NICE
Meta DescriptionAssessment, Diagnosis, Depression, CKS
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If a person has a suspected  diagnosis of depression: Ask about: The onset, duration, pattern, and severity of symptoms , including impact on daily functioning at work, on carer role(s), and on relationships including any safeguarding concerns for children or vulnerable adults in their care. See the CKS topic on Child maltreatment - recognition and management for more information. Current lifestyle including diet, physical activity, sleep; gambling, alcohol and/or substance misuse. See the CKS topics on Alcohol - problem drinking and Insomnia for more information. Any past history of depression and/or episodes of self-harm. See the CKS topic on Self-harm for more information. Any current symptoms or past history of coexisting mental health conditions, including mood elevation or psychotic symptoms suggesting bipolar disorder or psychotic depression, psychosis, anxiety, post-traumatic stress disorder (PTSD), or eating disorders. See the CKS topics on Bipolar disorder , Eating disorders , Generalized anxiety disorder , Post-traumatic stress disorder , and Psychosis and schizophrenia for more information. Any learning disability or acquired cognitive impairment including dementia, traumatic brain injury, or Parkinson's disease. See the CKS topics on Dementia , Head injury , Learning disabilities , and Parkinson's disease for more information. Any risk factors for depression including family history of depression, suicide, or self-harm; chronic physical health conditions; history of domestic violence. Current or previous supportive relationships including partner, other family, friends, carers; and support from any other statutory or voluntary organisations. Any recent or past stressful or traumatic life events, including difficult interpersonal relationships or relationship breakdown including divorce; job stress or redundancy; debt or financial difficulties; bereavement or other trauma; housing and living conditions; immigration status; social isolation. Any current or previous forensic history. Current medication, any previous treatments for depression, symptom response and any adverse effects. Always ask about any thoughts, ideas, plans, or intent to self-harm or commit suicide, and any protective factors. If there is a risk of self-harm or suicide: Assess the person's level of social support and awareness of sources of help. Arrange help appropriate to their level of need Advise the person to seek further help if their situation deteriorates. See the CKS topic on Self-harm for more information. Consider using a validated depression questionnaire to assess for depression, severity of symptoms, functioning, and response to treatment. See the section on Depression questionnaires  for more information. Assess the person's mental state and cognitive function. Consider performing a physical examination including neurological examination and arranging additional investigations, depending on clinical judgement, particularly if a coexisting condition or alternative cause for symptoms is suspected. See the section on Differential diagnosis for more information on possible alternative causes for symptoms. Depression questionnaires Depression questionnaires which are validated for use in primary care include: PHQ-9 (Patient Health Questionnaire-9) A nine-item, self-administered scale, which reflects the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fourth edition) criteria. It classifies current symptoms on a scale of 0 (not at all) to 3 (nearly every day) — the maximum score is 27. It can be downloaded free of charge from  www.phqscreeners.com . HADS (Hospital Anxiety and Depression Scale)  A self-administered scale, with 14 questions in total (seven covering depression and seven covering anxiety). The maximum score for each subscale is 21. Scores of 8–10, 11–14, and 15–21 represent cut-off points for mild, moderate, and severe depression respectively.  A paper version is available to purchase from  https://www.gl-assessment.co.uk/products/hospital-anxiety-and-depression-scale-hads/ . BDI-II (Beck Depression Inventory-II) A 21-item, self-administered scale that uses DSM-5 criteria. Each question is rated from 0 to 3 — the maximum score is 63. Scores of 14–19, 20–28, and 29–63 can be interpreted as mild, moderate, and severe depression respectively.   It is available to purchase from  www.pearsonassessments.com . In people who have concerns about gambling the NHS gambling questionnaire may be helpful https://www.nhs.uk/live-well/addiction-support/gambling-addiction/ .  Basis for recommendation The recommendations for assessment are based on the National Institute for Health and Care Excellence (NICE) guidelines Depression in adults: treatment and management  [ NICE, 2022b ], the NICE guideline Gambling-related harms: identification, assessment and management [ NICE, 2025 ] the British Association for Psychopharmacology (BAP) guidelines Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines  [ Cleare, 2015 ], and expert opinion in review articles on depression [ Malhi, 2018 ; Ferenchick, 2019 ]. Clinical features on history-taking These recommendations are based on the NICE guideline [ NICE, 2022b ], the BAP guidelines [ Cleare, 2015 ], expert opinion in review articles [ Malhi, 2018 ; Ferenchick, 2019 ], and are also pragmatic, based on what CKS considers to be good clinical practice. The BAP guidelines note that the use of antidepressants in people with undiagnosed bipolar disorder can trigger hypomania/mania. Using a validated depression questionnaire This recommendation is based on the NICE guideline [ NICE, 2022b ] and expert opinion in review articles [ Malhi, 2018 ; Ferenchick, 2019 ]. The NICE guideline notes that a validated questionnaire can help to assess symptoms, functioning, impairment, and evaluate treatment.  Assessing mental state and cognitive function This recommendation is based on the NICE guideline [ NICE, 2022b ] and expert opinion in a review article [ Ferenchick, 2019 ]. Cognitive testing can help to assess for coexisting or alternative conditions that may present with depressive symptoms, including neurological conditions and dementia [ Ferenchick, 2019 ]. Performing a physical examination and arranging additional investigations This recommendation is based on expert opinion in a review article [ Ferenchick, 2019 ]. It is also pragmatic, based on what CKS considers to be good clinical practice.
Markdown
- [Skip to content](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#content-start) - [Accessibility help](https://www.nice.org.uk/accessibility) Menu - [Guidance](https://www.nice.org.uk/guidance) - [Standards and indicators](https://www.nice.org.uk/standards-and-indicators) - [Clinical Knowledge Summaries (CKS)](https://cks.nice.org.uk/) - [![](data:image/svg+xml;base64,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)](https://cks.nice.org.uk/) - [Health topics A to Z](https://cks.nice.org.uk/topics/) - [Specialities](https://cks.nice.org.uk/specialities/) - [What's new](https://cks.nice.org.uk/whats-new/) - [About CKS](https://cks.nice.org.uk/about/) - [British National Formulary (BNF)](https://bnf.nice.org.uk/) - [BNF for Children (BNFC)](https://bnfc.nice.org.uk/) - [Life sciences](https://www.nice.org.uk/about/what-we-do/life-sciences) - More from NICE [Skip More from NICE submenu](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#content-start) ## Explore more from NICE - [What NICE does](https://www.nice.org.uk/what-nice-does) - [About us](https://www.nice.org.uk/about-us) - [Reusing our content](https://www.nice.org.uk/reusing-our-content) - [Implementing NICE guidance](https://www.nice.org.uk/implementing-nice-guidance) - [News, blogs and podcasts](https://www.nice.org.uk/news) - [Contact us](https://www.nice.org.uk/contact-us) - [Get involved](https://www.nice.org.uk/get-involved) - [Careers](https://www.nice.org.uk/careers) *** - [Join a committee](https://www.nice.org.uk/get-involved/our-committees) - [Comment on a consultation](https://www.nice.org.uk/get-involved/consultations) Close menu 1. [NICE](https://www.nice.org.uk/) 2. [CKS](https://cks.nice.org.uk/) 3. [Health topics A to Z](https://cks.nice.org.uk/topics/) 4. [Depression](https://cks.nice.org.uk/topics/depression/) 5. [Diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/) 6. Assessment # Depression: How should I assess a person with suspected depression? Last revised in April 2025 Print this page Assessment - [Summary](https://cks.nice.org.uk/topics/depression/) - [Have I got the right topic?](https://cks.nice.org.uk/topics/depression/have-i-got-the-right-topic/) - [How up-to-date is this topic?](https://cks.nice.org.uk/topics/depression/how-up-to-date-is-this-topic/) - [Goals and outcome measures](https://cks.nice.org.uk/topics/depression/goals-outcome-measures/) - [Background information](https://cks.nice.org.uk/topics/depression/background-information/) - [Diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/) - [Diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/diagnosis/) - [Assessment](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/) - [Differential diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/differential-diagnosis/) - [Management](https://cks.nice.org.uk/topics/depression/management/) - [Prescribing information](https://cks.nice.org.uk/topics/depression/prescribing-information/) - [Supporting evidence](https://cks.nice.org.uk/topics/depression/supporting-evidence/) - [How this topic was developed](https://cks.nice.org.uk/topics/depression/how-this-topic-was-developed/) - [References](https://cks.nice.org.uk/topics/depression/references/) ## On this page 1. [Depression questionnaires](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#depression-questionnaires) 2. [Basis for recommendation](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#basis-for-recommendation-0e7) ## How should I assess a person with suspected depression? **If a person has a **[suspected](https://cks.nice.org.uk/topics/depression/diagnosis/diagnosis/)** diagnosis of depression:** - **Ask about:** - The onset, duration, pattern, and severity of [symptoms](https://cks.nice.org.uk/topics/depression/diagnosis/diagnosis/), including impact on daily functioning at work, on carer role(s), and on relationships including any safeguarding concerns for children or vulnerable adults in their care. See the CKS topic on [Child maltreatment - recognition and management](https://cks.nice.org.uk/topics/child-maltreatment-recognition-management/) for more information. - Current lifestyle including diet, physical activity, sleep; gambling, alcohol and/or substance misuse. See the CKS topics on [Alcohol - problem drinking](https://cks.nice.org.uk/topics/alcohol-problem-drinking/) and [Insomnia](https://cks.nice.org.uk/topics/insomnia/) for more information. - Any past history of depression and/or episodes of self-harm. See the CKS topic on [Self-harm](https://cks.nice.org.uk/topics/self-harm/) for more information. - Any current symptoms or past history of coexisting mental health conditions, including mood elevation or psychotic symptoms suggesting bipolar disorder or psychotic depression, psychosis, anxiety, post-traumatic stress disorder (PTSD), or eating disorders. See the CKS topics on [Bipolar disorder](https://cks.nice.org.uk/topics/bipolar-disorder/), [Eating disorders](https://cks.nice.org.uk/topics/eating-disorders/), [Generalized anxiety disorder](https://cks.nice.org.uk/topics/generalized-anxiety-disorder/), [Post-traumatic stress disorder](https://cks.nice.org.uk/topics/post-traumatic-stress-disorder/), and [Psychosis and schizophrenia](https://cks.nice.org.uk/topics/psychosis-schizophrenia/) for more information. - Any learning disability or acquired cognitive impairment including dementia, traumatic brain injury, or Parkinson's disease. See the CKS topics on [Dementia](https://cks.nice.org.uk/topics/dementia/), [Head injury](https://cks.nice.org.uk/topics/head-injury/), [Learning disabilities](https://cks.nice.org.uk/topics/learning-disabilities/), and [Parkinson's disease](https://cks.nice.org.uk/topics/parkinsons-disease/) for more information. - Any [risk factors](https://cks.nice.org.uk/topics/depression/background-information/risk-factors/) for depression including family history of depression, suicide, or self-harm; chronic physical health conditions; history of domestic violence. - Current or previous supportive relationships including partner, other family, friends, carers; and support from any other statutory or voluntary organisations. - Any recent or past stressful or traumatic life events, including difficult interpersonal relationships or relationship breakdown including divorce; job stress or redundancy; debt or financial difficulties; bereavement or other trauma; housing and living conditions; immigration status; social isolation. - Any current or previous forensic history. - Current medication, any previous treatments for depression, symptom response and any adverse effects. - Always ask about any thoughts, ideas, plans, or intent to self-harm or commit suicide, and any protective factors. - If there is a risk of self-harm or suicide: - Assess the person's level of social support and awareness of sources of help. - Arrange help appropriate to their level of need - Advise the person to seek further help if their situation deteriorates. - See the CKS topic on [Self-harm](https://cks.nice.org.uk/topics/self-harm/) for more information. - **Consider using a validated depression questionnaire** to assess for depression, severity of symptoms, functioning, and response to treatment. - See the section on [Depression questionnaires](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#depression-questionnaires) for more information. - **Assess the person's mental state and cognitive function.** - **Consider performing a physical examination including neurological examination and arranging additional investigations,** depending on clinical judgement, particularly if a coexisting condition or alternative cause for symptoms is suspected. - See the section on [Differential diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/differential-diagnosis/) for more information on possible alternative causes for symptoms. ### Depression questionnaires - **Depression questionnaires which are validated for use in primary care include:** - **PHQ-9 (Patient Health Questionnaire-9)** - A nine-item, self-administered scale, which reflects the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fourth edition) criteria. - It classifies current symptoms on a scale of 0 (not at all) to 3 (nearly every day) — the maximum score is 27. - It can be downloaded free of charge from [www.phqscreeners.com](https://www.phqscreeners.com/select-screener). - **HADS (Hospital Anxiety and Depression Scale)** - A self-administered scale, with 14 questions in total (seven covering depression and seven covering anxiety). - The maximum score for each subscale is 21. - Scores of 8–10, 11–14, and 15–21 represent cut-off points for mild, moderate, and severe depression respectively. - A paper version is available to purchase from <https://www.gl-assessment.co.uk/products/hospital-anxiety-and-depression-scale-hads/>. - **BDI-II (Beck Depression Inventory-II)** - A 21-item, self-administered scale that uses DSM-5 criteria. - Each question is rated from 0 to 3 — the maximum score is 63. - Scores of 14–19, 20–28, and 29–63 can be interpreted as mild, moderate, and severe depression respectively. - It is available to purchase from [www.pearsonassessments.com](http://www.pearsonassessments.com/). - In people who have concerns about gambling the NHS gambling questionnaire may be helpful <https://www.nhs.uk/live-well/addiction-support/gambling-addiction/>. ### Basis for recommendation The recommendations for assessment are based on the National Institute for Health and Care Excellence (NICE) guidelines *Depression in adults: treatment and management* \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\], the NICE guideline *Gambling-related harms: identification, assessment and management* \[[NICE, 2025](https://cks.nice.org.uk/topics/depression/references/)\] the British Association for Psychopharmacology (BAP) guidelines *Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines* \[[Cleare, 2015](https://cks.nice.org.uk/topics/depression/references/)\], and expert opinion in review articles on depression \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. #### Clinical features on history-taking - These recommendations are based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\], the BAP guidelines \[[Cleare, 2015](https://cks.nice.org.uk/topics/depression/references/)\], expert opinion in review articles \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\], and are also pragmatic, based on what CKS considers to be good clinical practice. - The BAP guidelines note that the use of antidepressants in people with undiagnosed bipolar disorder can trigger hypomania/mania. #### Using a validated depression questionnaire - This recommendation is based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\] and expert opinion in review articles \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. - The NICE guideline notes that a validated questionnaire can help to assess symptoms, functioning, impairment, and evaluate treatment. #### Assessing mental state and cognitive function - This recommendation is based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\] and expert opinion in a review article \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. - Cognitive testing can help to assess for coexisting or alternative conditions that may present with depressive symptoms, including neurological conditions and dementia \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. #### Performing a physical examination and arranging additional investigations - This recommendation is based on expert opinion in a review article \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. It is also pragmatic, based on what CKS considers to be good clinical practice. The content on the NICE Clinical Knowledge Summaries site (CKS) is the copyright of [Clarity Informatics Limited (trading as Agilio Software Primary Care)](https://agiliosoftware.com/primary-care/). By using CKS, you agree to the licence set out in the [CKS End User Licence Agreement](https://www.nice.org.uk/terms-and-conditions/cks-end-user-licence-agreement). 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All rights reserved. Subject to [Notice of rights](https://www.nice.org.uk/terms-and-conditions#notice-of-rights).
Readable Markdown
**If a person has a **[suspected](https://cks.nice.org.uk/topics/depression/diagnosis/diagnosis/)** diagnosis of depression:** - **Ask about:** - The onset, duration, pattern, and severity of [symptoms](https://cks.nice.org.uk/topics/depression/diagnosis/diagnosis/), including impact on daily functioning at work, on carer role(s), and on relationships including any safeguarding concerns for children or vulnerable adults in their care. See the CKS topic on [Child maltreatment - recognition and management](https://cks.nice.org.uk/topics/child-maltreatment-recognition-management/) for more information. - Current lifestyle including diet, physical activity, sleep; gambling, alcohol and/or substance misuse. See the CKS topics on [Alcohol - problem drinking](https://cks.nice.org.uk/topics/alcohol-problem-drinking/) and [Insomnia](https://cks.nice.org.uk/topics/insomnia/) for more information. - Any past history of depression and/or episodes of self-harm. See the CKS topic on [Self-harm](https://cks.nice.org.uk/topics/self-harm/) for more information. - Any current symptoms or past history of coexisting mental health conditions, including mood elevation or psychotic symptoms suggesting bipolar disorder or psychotic depression, psychosis, anxiety, post-traumatic stress disorder (PTSD), or eating disorders. See the CKS topics on [Bipolar disorder](https://cks.nice.org.uk/topics/bipolar-disorder/), [Eating disorders](https://cks.nice.org.uk/topics/eating-disorders/), [Generalized anxiety disorder](https://cks.nice.org.uk/topics/generalized-anxiety-disorder/), [Post-traumatic stress disorder](https://cks.nice.org.uk/topics/post-traumatic-stress-disorder/), and [Psychosis and schizophrenia](https://cks.nice.org.uk/topics/psychosis-schizophrenia/) for more information. - Any learning disability or acquired cognitive impairment including dementia, traumatic brain injury, or Parkinson's disease. See the CKS topics on [Dementia](https://cks.nice.org.uk/topics/dementia/), [Head injury](https://cks.nice.org.uk/topics/head-injury/), [Learning disabilities](https://cks.nice.org.uk/topics/learning-disabilities/), and [Parkinson's disease](https://cks.nice.org.uk/topics/parkinsons-disease/) for more information. - Any [risk factors](https://cks.nice.org.uk/topics/depression/background-information/risk-factors/) for depression including family history of depression, suicide, or self-harm; chronic physical health conditions; history of domestic violence. - Current or previous supportive relationships including partner, other family, friends, carers; and support from any other statutory or voluntary organisations. - Any recent or past stressful or traumatic life events, including difficult interpersonal relationships or relationship breakdown including divorce; job stress or redundancy; debt or financial difficulties; bereavement or other trauma; housing and living conditions; immigration status; social isolation. - Any current or previous forensic history. - Current medication, any previous treatments for depression, symptom response and any adverse effects. - Always ask about any thoughts, ideas, plans, or intent to self-harm or commit suicide, and any protective factors. - If there is a risk of self-harm or suicide: - Assess the person's level of social support and awareness of sources of help. - Arrange help appropriate to their level of need - Advise the person to seek further help if their situation deteriorates. - See the CKS topic on [Self-harm](https://cks.nice.org.uk/topics/self-harm/) for more information. - **Consider using a validated depression questionnaire** to assess for depression, severity of symptoms, functioning, and response to treatment. - See the section on [Depression questionnaires](https://cks.nice.org.uk/topics/depression/diagnosis/assessment/#depression-questionnaires) for more information. - **Assess the person's mental state and cognitive function.** - **Consider performing a physical examination including neurological examination and arranging additional investigations,** depending on clinical judgement, particularly if a coexisting condition or alternative cause for symptoms is suspected. - See the section on [Differential diagnosis](https://cks.nice.org.uk/topics/depression/diagnosis/differential-diagnosis/) for more information on possible alternative causes for symptoms. ### Depression questionnaires - **Depression questionnaires which are validated for use in primary care include:** - **PHQ-9 (Patient Health Questionnaire-9)** - A nine-item, self-administered scale, which reflects the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, fourth edition) criteria. - It classifies current symptoms on a scale of 0 (not at all) to 3 (nearly every day) — the maximum score is 27. - It can be downloaded free of charge from [www.phqscreeners.com](https://www.phqscreeners.com/select-screener). - **HADS (Hospital Anxiety and Depression Scale)** - A self-administered scale, with 14 questions in total (seven covering depression and seven covering anxiety). - The maximum score for each subscale is 21. - Scores of 8–10, 11–14, and 15–21 represent cut-off points for mild, moderate, and severe depression respectively. - A paper version is available to purchase from <https://www.gl-assessment.co.uk/products/hospital-anxiety-and-depression-scale-hads/>. - **BDI-II (Beck Depression Inventory-II)** - A 21-item, self-administered scale that uses DSM-5 criteria. - Each question is rated from 0 to 3 — the maximum score is 63. - Scores of 14–19, 20–28, and 29–63 can be interpreted as mild, moderate, and severe depression respectively. - It is available to purchase from [www.pearsonassessments.com](http://www.pearsonassessments.com/). - In people who have concerns about gambling the NHS gambling questionnaire may be helpful <https://www.nhs.uk/live-well/addiction-support/gambling-addiction/>. ### Basis for recommendation The recommendations for assessment are based on the National Institute for Health and Care Excellence (NICE) guidelines *Depression in adults: treatment and management* \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\], the NICE guideline *Gambling-related harms: identification, assessment and management* \[[NICE, 2025](https://cks.nice.org.uk/topics/depression/references/)\] the British Association for Psychopharmacology (BAP) guidelines *Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines* \[[Cleare, 2015](https://cks.nice.org.uk/topics/depression/references/)\], and expert opinion in review articles on depression \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. #### Clinical features on history-taking - These recommendations are based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\], the BAP guidelines \[[Cleare, 2015](https://cks.nice.org.uk/topics/depression/references/)\], expert opinion in review articles \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\], and are also pragmatic, based on what CKS considers to be good clinical practice. - The BAP guidelines note that the use of antidepressants in people with undiagnosed bipolar disorder can trigger hypomania/mania. #### Using a validated depression questionnaire - This recommendation is based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\] and expert opinion in review articles \[[Malhi, 2018](https://cks.nice.org.uk/topics/depression/references/); [Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. - The NICE guideline notes that a validated questionnaire can help to assess symptoms, functioning, impairment, and evaluate treatment. #### Assessing mental state and cognitive function - This recommendation is based on the NICE guideline \[[NICE, 2022b](https://cks.nice.org.uk/topics/depression/references/)\] and expert opinion in a review article \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. - Cognitive testing can help to assess for coexisting or alternative conditions that may present with depressive symptoms, including neurological conditions and dementia \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. #### Performing a physical examination and arranging additional investigations - This recommendation is based on expert opinion in a review article \[[Ferenchick, 2019](https://cks.nice.org.uk/topics/depression/references/)\]. It is also pragmatic, based on what CKS considers to be good clinical practice.
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