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Raw Queries and Responses

1. Shard Calculation

Query:

Response:

Calculated Shard: 114 (from laksa123)

2. Crawled Status Check

Query:

curl -X POST \
  'http://laksa114.int.ahrefs:8124/' \
  -H 'Content-Type: text/plain' \
  -H 'X-ClickHouse-Database: crawler3' \
  -H 'Authorization: Basic YXBpOg==' \
  -d 'SELECT getAhrefsURLFromUnparsed(src_unparsed) AS found_url, ifNull(toUnixTimestamp(download_stamp), 0) AS crawl_time, ifNull(toUnixTimestamp(props_url_first_seen), 0) AS first_indexed_time, download_http_code AS http_code, src_unparsed AS src_unparsed, src_root_hash AS src_root_hash, history_drop_reason AS history_drop_reason, meta_title AS meta_title, meta_descriptions AS meta_descriptions, attrs_boilerpipe_text AS attrs_boilerpipe_text, attrs_markdown AS attrs_markdown, attrs_readable_markdown AS attrs_readable_markdown, meta_canonical AS meta_canonical, ml_categories_json AS ml_categories_json, ml_types_json AS ml_types_json, ml_intent_types_json AS ml_intent_types_json, meta_language AS meta_language, attrs_author AS attrs_author, ifNull(toUnixTimestamp(attrs_publish_time), 0) AS attrs_publish_time, ifNull(toUnixTimestamp(attrs_original_publish_time), 0) AS attrs_original_publish_time, ifNull(attrs_is_republished, 0) AS attrs_is_republished, ifNull(attrs_nr_words, 0) AS attrs_nr_words, ifNull(attrs_boilerpipe_nr_words, 0) AS attrs_boilerpipe_nr_words, ifNull(body_ext_links_number, 0) AS body_ext_links_number, ifNull(body_int_links_number, 0) AS body_int_links_number, ifNull(meta_nofollow, 0) AS meta_nofollow, ifNull(meta_noarchive, 0) AS meta_noarchive, ifNull(props_was_rendered, 0) AS props_was_rendered, ifNull(src_redirect, \'\') AS src_redirect, ifNull(download_time_msec, 0) AS download_time_msec, ifNull(download_ttfb_msec, 0) AS download_ttfb_msec, ifNull(download_size, 0) AS download_size FROM crawler3.page_info_local FINAL PREWHERE (src_root_hash, src_unparsed) IN ((getAhrefsRootHashFromUnparsed(getAhrefsUnparsedNoserviceFromURL(\'https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350\')), getAhrefsUnparsedNoserviceFromURL(\'https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350\'))) FORMAT JSONEachRow'

Response:

{"found_url":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350","crawl_time":1757517754,"first_indexed_time":0,"http_code":200,"src_unparsed":"com,wiley!onlinelibrary,chemistry-europe,\/doi\/abs\/10.1002\/slct.202502350 s443","src_root_hash":"1149036049361938514","history_drop_reason":null,"meta_title":"Exploring the Anticancer, Antibacterial Potency, and Molecular Docking of Synthesized Azo‐Ether and Azo‐Sulfone Compounds - Issa - 2025 - ChemistrySelect - Wiley Online Library","meta_descriptions":["The study investigates about synthesis of two products (bis-azo ether- based and bis-azo sulfone- based). The products were tested against breast cancer and lung cancer cell lines, as well as against...","Abstract This study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthes..."],"attrs_boilerpipe_text":"This study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthesis involved diazotization of 4,4′-oxydianiline (for product 4) or 4,4-sulfonyldianiline (for product 7) in a cold acidic medium, followed by coupling with 2-naphthol in a cold basic medium. The synthesis of the products were characterized by (IR, UV,  1 HNMR,  13 CNMR, and elemental analysis). Both targeted compounds exhibited significant biological activity, demonstrating potent anticancer effects against breast cancer cells (MCF-7) with IC 50  values of 6.06 and 5.696, and reduce the survival rate of lung cancer cells (A549) by IC 50  values of 6.372 and 5.768 for compounds 4 and 7, respectively. Moreover, the products showed strong antibacterial activity against  Escherichia coli  and  Staphylococcus aureus . Computational studies supported the experimental findings, suggesting their potential as promising dual-action anticancer and antibacterial agents.","attrs_markdown":"- Skip to Article Content\n- Skip to Article Information\n\n[![Chemistry Europe](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/pb-assets\/hub-assets\/chemistry-europe\/logo-header-1584460287277.png)](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/)\n\n[![Chemistry Europe](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/pb-assets\/hub-assets\/chemistry-europe\/mobilehublogo-1584460287277.png)](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/)\n\nSearch within\n\nLogin \/ Register\n\n- [Individual login](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/showLogin?acdl-redirect=true&uri=%2Fdoi%2Fabs%2F10.1002%2Fslct.202502350)\n- [Institutional login](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/ssostart?redirectUri=%2Fdoi%2Fabs%2F10.1002%2Fslct.202502350)\n- [REGISTER](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/registration?redirectUri=%2Fdoi%2Fabs%2F10.1002%2Fslct.202502350&acdl-redirect=true)\n\n- [Journals](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350 \"Journals\")\n  - 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[Spotlighting Early-Career Chemistry Researchers in the Netherlands](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/toc\/10.1002\/\$ISSN\$1521-3765.ECR_Spotlight_Netherlands \"Spotlighting Early-Career Chemistry Researchers in the Netherlands\")\n  - [All Special Collections](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/topic\/vi-categories-99990001\/special-collections\/99990001 \"All Special Collections\")\n- [GET IN TOUCH WITH US](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/hub\/contact \"GET IN TOUCH WITH US\")\n\n- [WeChat](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/pb-assets\/assets\/vch\/wechat-wiley-chem-1660202483563.pdf)\n\n[![](https:\/\/pubads.g.doubleclick.net\/gampad\/ad?iu=$googlePublisherCategory&sz=728x90&tile=1&c=$random)](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/clickThrough?id=1013&url=https%3A%2F%2Fpubads.g.doubleclick.net%2Fgampad%2Fjump%3Fiu%3D%24googlePublisherCategory%26amp%3Bsz%3D728x90%26amp%3Btile%3D1%26amp%3Bc%3D%24random&loc=%2Fdoi%2Fabs%2F10.1002%2Fslct.202502350&pubId=89219785&placeholderId=1015&productId=101018)\n\n[ChemistrySelect](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/journal\/23656549 \"ChemistrySelect homepage\")\n\n[Volume 10, Issue 35](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/toc\/23656549\/2025\/10\/35) e02350[![ChemistrySelect](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/pb-assets\/journal-banners\/23656549-1688630202673.jpg)](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/journal\/23656549 \"ChemistrySelect homepage\")\n\nResearch Article\n\n# Exploring the Anticancer, Antibacterial Potency, and Molecular Docking of Synthesized Azo-Ether and Azo-Sulfone Compounds\n[Kovan Dilawer Issa](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Issa\/Kovan+Dilawer),\n\nCorresponding Author\n\nKovan Dilawer Issa\n\n- [\\[email protected\\]](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cdn-cgi\/l\/email-protection#ed86829b8c83c38984818c9a889fad998498c3888998c3849c \"Link to email address\")\n\n- [orcid.org\/0000-0003-2860-0246](https:\/\/orcid.org\/0000-0003-2860-0246)\n\nMedical Analysis Department, Tishk International University, Erbil, Kurdistan Region, 44001 Iraq\n\nE-mail: [\\[email protected\\]](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cdn-cgi\/l\/email-protection#b0dbdfc6d1de9ed4d9dcd1c7d5c2f0c4d9c59ed5d4c59ed9c1 \"Link to email address\")\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Issa\/Kovan+Dilawer)\n\n[Dalia A. Abdul](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Abdul\/Dalia+A.),\n\nDalia A. Abdul\n\nDepartment of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Abdul\/Dalia+A.)\n\n[Soran O. Mamand](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Mamand\/Soran+O.),\n\nSoran O. Mamand\n\nDepartment of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Mamand\/Soran+O.)\n\n[Nihayat Omar Ahmad](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Ahmad\/Nihayat+Omar),\n\nNihayat Omar Ahmad\n\nDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, 44001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Ahmad\/Nihayat+Omar)\n\n[Amnah Mohammed Salih](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Salih\/Amnah+Mohammed),\n\nAmnah Mohammed Salih\n\nMedical Analysis Department, Tishk International University, Erbil, Kurdistan Region, 44001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Salih\/Amnah+Mohammed)\n\n[Sangar Ali Hassan](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Hassan\/Sangar+Ali),\n\nSangar Ali Hassan\n\nDepartment of Chemistry, College of Sciences, University of Raparin, Kurdistan Regional Government, Ranyah, 46012 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Hassan\/Sangar+Ali)\n\n[Kovan Dilawer Issa](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Issa\/Kovan+Dilawer),\n\nCorresponding Author\n\nKovan Dilawer Issa\n\n- [\\[email protected\\]](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cdn-cgi\/l\/email-protection#0962667f6867276d6065687e6c7b497d607c276c6d7c276078 \"Link to email address\")\n\n- [orcid.org\/0000-0003-2860-0246](https:\/\/orcid.org\/0000-0003-2860-0246)\n\nMedical Analysis Department, Tishk International University, Erbil, Kurdistan Region, 44001 Iraq\n\nE-mail: [\\[email protected\\]](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cdn-cgi\/l\/email-protection#315a5e47505f1f55585d50465443714558441f5455441f5840 \"Link to email address\")\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Issa\/Kovan+Dilawer)\n\n[Dalia A. Abdul](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Abdul\/Dalia+A.),\n\nDalia A. Abdul\n\nDepartment of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Abdul\/Dalia+A.)\n\n[Soran O. Mamand](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Mamand\/Soran+O.),\n\nSoran O. Mamand\n\nDepartment of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Mamand\/Soran+O.)\n\n[Nihayat Omar Ahmad](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Ahmad\/Nihayat+Omar),\n\nNihayat Omar Ahmad\n\nDepartment of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, 44001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Ahmad\/Nihayat+Omar)\n\n[Amnah Mohammed Salih](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Salih\/Amnah+Mohammed),\n\nAmnah Mohammed Salih\n\nMedical Analysis Department, Tishk International University, Erbil, Kurdistan Region, 44001 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Salih\/Amnah+Mohammed)\n\n[Sangar Ali Hassan](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Hassan\/Sangar+Ali),\n\nSangar Ali Hassan\n\nDepartment of Chemistry, College of Sciences, University of Raparin, Kurdistan Regional Government, Ranyah, 46012 Iraq\n\n[Search for more papers by this author](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/authored-by\/Hassan\/Sangar+Ali)\n\nFirst published: 09 September 2025\n\n<https:\/\/doi.org\/10.1002\/slct.202502350>\n\n[Read the full text](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full\/10.1002\/slct.202502350)\n\n[About]()\n\n[![](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/specs\/products\/acropolis\/pericles\/releasedAssets\/images\/pdf-icon-169a2eb30e52100e76dfa5f4b66998e6.png)PDF](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/slct.202502350 \"ePDF\")\n\n[Tools](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)\n\n- [Request permission](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/rightsLink?doi=10.1002%2Fslct.202502350&mode=)\n- [Export citation](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/showCitFormats?doi=10.1002%2Fslct.202502350)\n- [Add to favorites](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/personalize\/addFavoritePublication?doi=10.1002%2Fslct.202502350)\n- [Track citation](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/addCitationAlert?doi=10.1002%2Fslct.202502350)\n\n[Share](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)[Share](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)\n\nGive access\n\n[Share full text access](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)\n\nShare full-text access\n\nShare a link\n\nShare on\n\n- [Email](\"Email\")\n- [Facebook](\"Facebook\")\n- [x](\"x\")\n- [LinkedIn](\"LinkedIn\")\n- [Reddit](\"Reddit\")\n- [Wechat](\"Wechat\")\n- [Bluesky](\"Bluesky\")\n\n### Graphical Abstract\nThe study investigates about synthesis of two products (bis-azo ether- based and bis-azo sulfone- based). The products were tested against breast cancer and lung cancer cell lines, as well as against *Escherichia coli* and *Staphylococcus aureus*. The results showed efficient activity of the products to stop the proliferation of the cancer cells and inhibit the growth of bacteria. The molecular docking performed and located the efficiency of the products to bind the proteins.\n\n[![Description unavailable](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cms\/asset\/d53c7122-ba73-4633-becc-4f4837085db1\/slct71172-gra-0001-m.png)](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/cms\/asset\/45a337be-7361-418f-888b-f40138fe9b9a\/slct71172-gra-0001-m.jpg)\n\n### Abstract\nThis study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthesis involved diazotization of 4,4′-oxydianiline (for product 4) or 4,4-sulfonyldianiline (for product 7) in a cold acidic medium, followed by coupling with 2-naphthol in a cold basic medium. The synthesis of the products were characterized by (IR, UV, 1HNMR, 13CNMR, and elemental analysis). Both targeted compounds exhibited significant biological activity, demonstrating potent anticancer effects against breast cancer cells (MCF-7) with IC50 values of 6.06 and 5.696, and reduce the survival rate of lung cancer cells (A549) by IC50 values of 6.372 and 5.768 for compounds 4 and 7, respectively. Moreover, the products showed strong antibacterial activity against *Escherichia coli* and *Staphylococcus aureus*. Computational studies supported the experimental findings, suggesting their potential as promising dual-action anticancer and antibacterial agents.\n\n## Conflict of Interests\nThe authors declare no conflict of interest.\n\n## [Open Research](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)\n#\n# Data Availability Statement\nThe data that support the findings of this study are available from the corresponding author upon reasonable request.\n\n## [Supporting Information]()\n| Filename | Description |\n|---|---|\n| [slct71172-sup-0001-SuppMat.docx](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/action\/downloadSupplement?doi=10.1002%2Fslct.202502350&file=slct71172-sup-0001-SuppMat.docx)1\\.1 MB | Supporting Information |\n\nPlease note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.\n\n## [References](https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/slct.202502350)\n- 1S. M. Alzahrani, H. A. Al Doghaither, A. B. Al‑Ghafari, *Mol. Clin. 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Meta Title	Exploring the Anticancer, Antibacterial Potency, and Molecular Docking of Synthesized Azo‐Ether and Azo‐Sulfone Compounds - Issa - 2025 - ChemistrySelect - Wiley Online Library
Meta Description	The study investigates about synthesis of two products (bis-azo ether- based and bis-azo sulfone- based). The products were tested against breast cancer and lung cancer cell lines, as well as against..., Abstract This study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthes...
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Boilerpipe Text	This study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthesis involved diazotization of 4,4′-oxydianiline (for product 4) or 4,4-sulfonyldianiline (for product 7) in a cold acidic medium, followed by coupling with 2-naphthol in a cold basic medium. The synthesis of the products were characterized by (IR, UV, 1 HNMR, 13 CNMR, and elemental analysis). Both targeted compounds exhibited significant biological activity, demonstrating potent anticancer effects against breast cancer cells (MCF-7) with IC 50 values of 6.06 and 5.696, and reduce the survival rate of lung cancer cells (A549) by IC 50 values of 6.372 and 5.768 for compounds 4 and 7, respectively. Moreover, the products showed strong antibacterial activity against Escherichia coli and Staphylococcus aureus . Computational studies supported the experimental findings, suggesting their potential as promising dual-action anticancer and antibacterial agents.
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Abdul](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Abdul/Dalia+A.), Dalia A. Abdul Department of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq [Search for more papers by this author](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Abdul/Dalia+A.) [Soran O. Mamand](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Mamand/Soran+O.), Soran O. Mamand Department of Chemistry, College of Science, University of Sulaimani, Sulaimani, Kurdistan Region, 46001 Iraq [Search for more papers by this author](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Mamand/Soran+O.) [Nihayat Omar Ahmad](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Ahmad/Nihayat+Omar), Nihayat Omar Ahmad Department of Chemistry, College of Science, Salahaddin University-Erbil, Erbil, Kurdistan Region, 44001 Iraq [Search for more papers by this author](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Ahmad/Nihayat+Omar) [Amnah Mohammed Salih](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Salih/Amnah+Mohammed), Amnah Mohammed Salih Medical Analysis Department, Tishk International University, Erbil, Kurdistan Region, 44001 Iraq [Search for more papers by this author](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Salih/Amnah+Mohammed) [Sangar Ali Hassan](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Hassan/Sangar+Ali), Sangar Ali Hassan Department of Chemistry, College of Sciences, University of Raparin, Kurdistan Regional Government, Ranyah, 46012 Iraq [Search for more papers by this author](https://chemistry-europe.onlinelibrary.wiley.com/authored-by/Hassan/Sangar+Ali) First published: 09 September 2025 <https://doi.org/10.1002/slct.202502350> [Read the full text](https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202502350) [About]() [![](https://chemistry-europe.onlinelibrary.wiley.com/specs/products/acropolis/pericles/releasedAssets/images/pdf-icon-169a2eb30e52100e76dfa5f4b66998e6.png)PDF](https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202502350 "ePDF") [Tools](https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350) - [Request permission](https://chemistry-europe.onlinelibrary.wiley.com/action/rightsLink?doi=10.1002%2Fslct.202502350&mode=) - [Export citation](https://chemistry-europe.onlinelibrary.wiley.com/action/showCitFormats?doi=10.1002%2Fslct.202502350) - [Add to favorites](https://chemistry-europe.onlinelibrary.wiley.com/personalize/addFavoritePublication?doi=10.1002%2Fslct.202502350) - [Track citation](https://chemistry-europe.onlinelibrary.wiley.com/action/addCitationAlert?doi=10.1002%2Fslct.202502350) [Share](https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350)[Share](https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350) Give access [Share full text access](https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350) Share full-text access Share a link Share on - [Email]("Email") - [Facebook]("Facebook") - [x]("x") - [LinkedIn]("LinkedIn") - [Reddit]("Reddit") - [Wechat]("Wechat") - [Bluesky]("Bluesky") ### Graphical Abstract The study investigates about synthesis of two products (bis-azo ether- based and bis-azo sulfone- based). The products were tested against breast cancer and lung cancer cell lines, as well as against Escherichia coli and Staphylococcus aureus. The results showed efficient activity of the products to stop the proliferation of the cancer cells and inhibit the growth of bacteria. The molecular docking performed and located the efficiency of the products to bind the proteins. [![Description unavailable](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/d53c7122-ba73-4633-becc-4f4837085db1/slct71172-gra-0001-m.png)](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/45a337be-7361-418f-888b-f40138fe9b9a/slct71172-gra-0001-m.jpg) ### Abstract This study presents efficient synthesis and characterization of two compounds; a bis azo ether (4) and a bis azo sulfone (7), obtaining via a fast, easy, and high-yield method. The synthesis involved diazotization of 4,4′-oxydianiline (for product 4) or 4,4-sulfonyldianiline (for product 7) in a cold acidic medium, followed by coupling with 2-naphthol in a cold basic medium. The synthesis of the products were characterized by (IR, UV, 1HNMR, 13CNMR, and elemental analysis). Both targeted compounds exhibited significant biological activity, demonstrating potent anticancer effects against breast cancer cells (MCF-7) with IC50 values of 6.06 and 5.696, and reduce the survival rate of lung cancer cells (A549) by IC50 values of 6.372 and 5.768 for compounds 4 and 7, respectively. Moreover, the products showed strong antibacterial activity against Escherichia coli and Staphylococcus aureus. Computational studies supported the experimental findings, suggesting their potential as promising dual-action anticancer and antibacterial agents. ## Conflict of Interests The authors declare no conflict of interest. ## [Open Research](https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/slct.202502350) # # Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. ## [Supporting Information]() \| Filename \| Description \| \|---\|---\| \| [slct71172-sup-0001-SuppMat.docx](https://chemistry-europe.onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fslct.202502350&file=slct71172-sup-0001-SuppMat.docx)1\.1 MB \| Supporting Information \| Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. 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